A critical review of the composition and history of safe use of guayusa: a stimulant and antioxidant novel food

References

• Adhikary, R., and V. Mandal. 2017. L-theanine: a potential multifaceted natural bioactive amide as health supplement. Asian Pacific Journal of Tropical Biomedicine 7 (9):842–8. doi: 10.1016/j.apjtb.2017.08.005.
   Web of Science ®Google Scholar
• Adnan, M., A. Ahmad, A. Ahmed, N. Khalid, I. Hayat, and I. Ahmed. 2013. Chemical composition and sensory evaluation of tea (Camellia sinensis) commercialized in Pakistan. Pakistan Journal of Botany 45 (3):901–7.
   Web of Science ®Google Scholar
• Ahmad, R. S., M. S. Butt, N. Huma, M. T. Sultan, M. U. Arshad, Z. Mushtaq, and F. Saeed. 2014. Quantitative and qualitative portrait of green tea catechins (Gtc) through HPLC. International Journal of Food Properties 17 (7):1626–36. doi: 10.1080/10942912.2012.723232.
   Web of Science ®Google Scholar
• Albis, M. M. (Pbro). 1936. Memorias de un viajero (1854). Rev. Popayan XXVI (163–165):28–32.
   Google Scholar
• Alikaridis, F. 1987. Natural constituents of Ilex species. Journal of Ethnopharmacology 20 (2):121–44.
   PubMed Web of Science ®Google Scholar
• Bailey, C. J., and C. Day. 1989. Traditional plant medicines as treatments for diabetes. Diabetes Care 12 (8):553–64. doi: 10.2337/diacare.12.8.553.
   PubMed Web of Science ®Google Scholar
• Barriga Coronel, G. 2017. Determinacion del contenido de cafeína en infusiones de hoya de guayusa (Ilex guayusa) bajo dos condiciones de secado. Faculdad Ingenieria, Universidad de Los Andes, Quito, Ecuador.
   Google Scholar
• Bast, A., R. F. Chandler, P. C. Choy, L. M. Delmulle, J. Gruenwald, S. A. Halkes, K. Keller, J. H. Koeman, P. Peters, H. Przyrembel, et al. 2002. Botanical health products: positioning and requirements for effective and safe use. Environmental Toxicology and Pharmacology 12 (4):195–211. doi: 10.1016/S1382-6689(02)00035-2.
   PubMed Web of Science ®Google Scholar
• Bennett, B. C. 1992. Hallucinogenic plants of the Shuar and related indigenous groups in Amazonian Ecuador and Peru. Brittonia 44 (4):483–93. doi: 10.2307/2807199.
   Web of Science ®Google Scholar
• Bennett, B. C., M. A. Baker, and P. G. Andrade. 2002. Ethnobotany of the Shuar of Eastern Ecuador. Bronx, NY: New York Botanical Garden Press.
   Google Scholar
• Blaauboer, B. J., A. R. Boobis, B. Bradford, A. Cockburn, A. Constable, M. Daneshian, G. Edwards, J. A. Garthoff, B. Jeffery, and C. Krul. 2016. Considering new methodologies in strategies for safety assessment of foods and food ingredients. Food and Chemical Toxicology 91:19–35. doi: 10.1016/j.fct.2016.02.019.
   PubMed Web of Science ®Google Scholar
• Bryan, J. 2008. Psychological effects of dietary components of tea: Caffeine and L-theanine. Nutrition Reviews 66 (2):82–90. doi: 10.1111/j.1753-4887.2007.00011.x.
   PubMed Web of Science ®Google Scholar
• Burrows, G. E., and R. J. Tyrl. 2013. Aquifoliaceae. In Toxic plants of North America, ed. G. E. Burrows and R. J. Tyrl, 127–30. 2nd ed. Ames: Wiley-Blackwell. doi:10.1002/9781118413425.
   Google Scholar
• Bussmann, R. W., A. Glenn, and D. Sharon. 2010. Antibacterial activity of medicinal plants of Northern Peru – can traditional applications provide leads for modern science? Indian Journal of Traditional Knowledge 9 (4):742–53.
   Web of Science ®Google Scholar
• Bussmann, R. W., G. Malca, A. Glenn, D. Sharon, B. Nilsen, B. Parris, D. Dubose, D. Ruiz, J. Saleda, and M. Martinez. 2011. Toxicity of medicinal plants used in traditional medicine in Northern Peru. Journal of Ethnopharmacology 137 (1):121–40. doi: 10.1016/j.jep.2011.04.071.
   PubMed Web of Science ®Google Scholar
• Bussmann, R. W., G. Malca-García, A. Glenn, D. Sharon, G. Chait, D. Díaz, K. Pourmand, B. Jonat, S. Somogy, and G. Guardado. 2010. Minimum inhibitory concentrations of medicinal plants used in Northern Peru as antibacterial remedies. Journal of Ethnopharmacology 132 (1):101–8. doi: 10.1016/j.jep.2010.07.048.
   PubMed Web of Science ®Google Scholar
• Casimir, J., J. Jadot, and M. Renard. 1960. Separation and characterization of N-ethyl-gamma-glutamine from Xerocomus badius. Biochimica et Biophysica Acta 39 (3):462–8. doi: 10.1016/0006-3002(60)90199-2.
   PubMedGoogle Scholar
• Chatterjee, S., A. Chatterjee, and S. Bandyopadhyay. 2016a. L-theanine: a prospective natural medicine. International Journal of Pharmaceutical Sciences Review and Research 41 (2):95–103.
   Google Scholar
• Chatterjee, S., A. Chatterjee, and S. Bandyopadhyay. 2016b. Seasonal variation of l-theanine content in tea: a study on darjeeling black tea. International Journal of Scientific Research in Science, Engineering and Technology 2 (3):522–4.
   Google Scholar
• Chianese, G., S. D. Golin-Pacheco, O. Taglialatela-Scafati, J. A. Collado, E. Munoz, G. Appendino, and F. Pollastro. 2019. Bioactive triterpenoids from the caffeine-rich plants guayusa and maté. Food Research International 115:504–10. doi: 10.1016/j.foodres.2018.10.005.
   PubMed Web of Science ®Google Scholar
• Cobos Morales, L. A. 2016. Determinación del contenido de cafeína en un cultivo comercial de guayusa (Ilex guayusa). Faculdad de Ciencias Agrícolas, Universidad Central del Ecuador, Quito, Ecuador.
   Google Scholar
• Contero, F., S. Abdo, D. Vinueza, J. Moreno, M. Tuquinga, and N. Paca. 2015. Estrogenic activity of ethanolic extracts from leaves of Ilex guayusa Loes. and Medicago sativa in Rattus norvegicus. Pharmacology online 2:95–99.
   Google Scholar
• Cooper, J. M., and J. H. Steward. 1949. Stimulants and narcotics. In The comparative ethnology South American Indians, ed. J. H. Steward, 5:546–47. Washington, DC: Government Printing Office.
   Google Scholar
• Coppens, P., L. Delmulle, O. Gulati, D. Richardson, M. Ruthsatz, H. Sievers, and S. Sidani. 2006. Use of botanicals in food supplements: Regulatory scope, scientific risk assessment. Annals of Nutrition and Metabolism 50 (6):538–54. doi: 10.1159/000098146.
   PubMed Web of Science ®Google Scholar
• da Costa, A. M. G., E. M. Nogami, J. V. Visentainer, N. E. de Souza, and E. E. Garcia. 2009. Fractionation of aluminum in commercial green and roasted yerba mate samples (Ilex paraguariensis St.Hil.) and in their infusions. Journal of Agricultural and Food Chemistry 57 (1):196–200. doi: 10.1021/jf802808h.
   PubMed Web of Science ®Google Scholar
• de la Torre,L., H. Navarrete, M. P. Muriel, M. J. Macía, and H. Balslev. 2008. Enciclopedia de Las Plantas Útiles Del Ecuador. Quito and Aarhus: Herbario QCA and Herbario AAU.
   Google Scholar
• Descola, P. 1996. In the society of nature: a native ecology in Amazonia. Cambridge, United Kingdom: Cambridge University Press.
   Google Scholar
• Dueñas, J. F., C. Jarrett, I. Cummins, and E. Logan–Hines. 2016. Amazonian guayusa (Ilex guayusa Loes.): a historical and ethnobotanical overview. Economic Botany 70 (1):85–91. doi: 10.1007/s12231-016-9334-2.
   Web of Science ®Google Scholar
• Dugo, P., F. Cacciola, P. Donato, R. A. Jacques, E. B. Caramão, and L. Mondello. 2009. High efficiency liquid chromatography techniques coupled to mass spectrometry for the characterization of mate extracts. Journal of Chromatography A 1216 (43):7213–21. doi: 10.1016/j.chroma.2009.08.030.
   PubMed Web of Science ®Google Scholar
• Fabiansson, S. U. 2013. Public health measures: Assessment of novel foods and ingredients. In Encyclopedia of food safety, 4:62–67. Castlecrag, NSW, Australia: Elsevier. doi:10.1016/B978-0-12-378612-8.00350-4.
   Google Scholar
• Flaten, T. 2002. Aluminium in tea: Concentrations, speciation and bioavailability. Coordination Chemistry Reviews 228 (2):385–95. doi: 10.1016/S0010-8545(02)00036-X.
   Web of Science ®Google Scholar
• Galle, F. C. 1997. Hollies. The genus Ilex. Portland, USA: Timber Press.
   Google Scholar
• Gamboa, F., C.-C. Muñoz, G. Numpaque, L. G. Sequeda-Castañeda, S. J. Gutierrez, and N. Tellez. 2018. Antimicrobial activity of Piper marginatum Jacq and Ilex guayusa Loes on microorganisms associated with periodontal disease. International Journal of Microbiology. 2018:1–9. doi: 10.1155/2018/4147383.
   Web of Science ®Google Scholar
• García, H. B. 1992. Ilex guayusa. In Flora medicinal de Colombia botánica médica, 139–43. 2nd ed. Bogotá, Colombia: Tercer Mundo Editores.
   Google Scholar
• García-Ruiz, A., N. Baenas, A. M. Benítez-González, C. M. Stinco, A. J. Meléndez-Martínez, D. A. Moreno, and J. Ruales. 2017. Guayusa (Ilex guayusa L.) new tea: Phenolic and carotenoid composition and antioxidant capacity. Journal of the Science of Food and Agriculture 97 (12):3929–36. doi: 10.1002/jsfa.8255.
   PubMed Web of Science ®Google Scholar
• García-Ruiz, A., N. Baenas, A. M. Benítez-González, C. M. Stinco, A. J. Meléndez-Martínez, D. A. Moreno, J. Ruales, and D. R. Heldman. 2016. Bioactive compounds and antioxidant capacity of green and processed leaves of guayusa (Ilex paraguariensis Loes). In Proceedings of the II International Conference on Food Chemistry & Technology (FCT-2016), ed. D. R. Heldman, 2:S8–S9. doi:10.17756/jfcn.2016-suppl4.
   Google Scholar
• Garrido-Pérez, E. I., K. L. Sidali, J. Rojas-Salvatierra, D. Tella-Ruíz, Á. Cajas, and M. S. Peña. 2018. Lecciones ecológicas de la historia amazónica: impacto diferencial del uso del suelo en las estructuras y biomasas aéreas de bosques secundarios en Napo, Ecuador. Bosque (Valdivia) 39 (1):37–48. doi: 10.4067/S0717-92002018000100037.
   Google Scholar
• Gill, R. C. 1940. White water and black magic. New York, NY: Henry Holt and Company.
   Google Scholar
• Giulian, R., C. E. Iochims dos Santos, S. de Moraes Shubeita, L. M. da Silva, J. F. Dias, and M. L. Yoneama. 2007. Elemental characterization of commercial mate tea leaves (Ilex paraguariensis A.St.-Hil.) before and after hot water infusion using ion beam techniques. Journal of Agricultural and Food Chemistry 55 (3):741–6. doi: 10.1021/jf062456r.
   PubMed Web of Science ®Google Scholar
• Heck, C. I., and E. G. de Mejia. 2007. Yerba mate tea (Ilex paraguariensis): a comprehensive review on chemistry, health implications, and technological considerations. Journal of Food Science 72 (9):R138–51. doi: 10.1111/j.1750-3841.2007.00535.x.
   PubMed Web of Science ®Google Scholar
• Holmstedt, B., and J.-E. Lindgren. 1972. Alkaloid analyses of botanical material more than a thousand years old. In A medicine man's implements and plants in a Tiahuanacoid tomb in highland Bolivia, ed. S. H. Wassen, 32:139–44. Goteborg: Goteborgs Ethnografiska Museum.
   Google Scholar
• Howlett, J., D. G. Edwards, A. Cockburn, P. Hepburn, J. Kleiner, D. Knorr, and G. Kozianowski. 2003. The safety assessment of novel foods and concepts to determine their safety in use. Journal of Food Science & Nutrition 54 (Supp1):S1–S32. doi: 10.1080/09637480310001610308.
   Google Scholar
• Iglesias, G. 1987. Hierbas Medicinales de Los Quichuas Del Napo. Quito, Ecuador: Ediciones Abya-Yala. doi: 10.1086/ahr/108.4.1193.
   Google Scholar
• Infinium Global Research. 2018. Herbal tea market: Global industry analysis, trends, market size and forecasts up to 2024. Bopodi, India: Infinium Global Research.
   Google Scholar
• Innerhofer, S., and K. G. Bernhardt. 2011. Ethnobotanic garden design in the Ecuadorian Amazon. Biodiversity and Conservation 20 (2):429–39. doi: 10.1007/s10531-010-9984-9.
   Web of Science ®Google Scholar
• Jaiswal, R., T. Sovdat, F. Vivan, and N. Kuhnert. 2010. Profiling and characterization by LC-MSn of the chlorogenic acids and hydroxycinnamoylshikimate esters in mate (Ilex paraguariensis). Journal of Agricultural and Food Chemistry 58 (9):5471–84. doi: 10.1021/jf904537z.
   PubMed Web of Science ®Google Scholar
• Jansen, S., T. Watanabe, and E. Smets. 2002. Aluminium accumulation in leaves of 127 species in Melastomataceae, with comments on the order myrtales. Annals of Botany 90 (1):53–64. doi: 10.1093/aob/mcf142.
   PubMed Web of Science ®Google Scholar
• Jara, A., Y. Rodriguez, J. Cornejo, M. E. Cazar, M. Gutierrez, and L. Astudillo. 2013. Antioxidant activity and total phenolics of plants used in traditional medicine in Ecuador. The 17th International Electronic Conference on Synthetic Organic Chemistry. Sciforum Electronic Conference Series: Sciforum Electronic Conference Series. doi:10.3390/ecsoc-17-b001.
   Google Scholar
• Jarrett, C., I. Cummins, and E. Logan-Hines. 2017. Adapting indigenous agroforestry systems for integrative landscape management and sustainable supply chain development in Napo, Ecuador. In Integrating landscapes: Agroforestry for biodiversity conservation and food sovereignty, ed. F. Montagnini, 12:283–309. Cham: Springer. doi:10.1007/978-3-319-69371-2_12.
   Google Scholar
• Juneja, L. R., D.-C. Chu, T. Okubo, Y. Nagato, and H. Yokogoshi. 1999. L-theanine—a unique amino acid of green tea and its relaxation effect in humans. Trends in Food Science & Technology 10 (6–7):199–204. doi: 10.1016/S0924-2244(99)00044-8.
   Web of Science ®Google Scholar
• Kamangar, F., M. M. Schantz, C. C. Abnet, R. B. Fagundes, and S. M. Dawsey. 2008. High levels of carcinogenic polycyclic aromatic hydrocarbons in mate drinks. Cancer Epidemiology, Biomarkers & Prevention 17 (5):1262–8. doi: 10.1158/1055-9965.EPI-08-0025.
   PubMed Web of Science ®Google Scholar
• Kapp, R. W., O. Mendes, S. Roy, R. S. McQuate, and R. Kraska. 2016. General and genetic toxicology of guayusa concentrate (Ilex guayusa). International Journal of Toxicology 35 (2):222–42. doi: 10.1177/1091581815625594.
   PubMed Web of Science ®Google Scholar
• Karsten, R. 1935. The head-hunters of Western Amazonas. The life and culture of the Jibaro Indians of Eastern Ecuador and Peru. Helsingfors: Helsingfors Centraltryck.
   Google Scholar
• Kimura, R., and T. Murata. 1986. Effect of theanine on norepinephrine and serotonin levels in rat brain. Chemical & Pharmaceutical Bulletin 34 (7):3053–7. doi: 10.1248/cpb.34.3053.
   PubMed Web of Science ®Google Scholar
• Kitaoka, S., H. Hayashi, H. Yokogoshi, and Y. Suzuki. 1996. Transmural potential changes associated with the in vitro absorption of theanine in the Guinea pig intestine. Bioscience, Biotechnology, and Biochemistry 60 (11):1768–71. doi: 10.1271/bbb.60.1768.
   PubMed Web of Science ®Google Scholar
• Knudsen, I., I. Søborg, F. Eriksen, K. Pilegaard, and J. Pedersen. 2008. Risk management and risk assessment of novel plant foods: Concepts and principles. Food and Chemical Toxicology 46 (5):1681–705. doi: 10.1016/j.fct.2008.01.022.
   PubMed Web of Science ®Google Scholar
• Kochian, L. V., O. A. Hoekenga, and M. A. Piñeros. 2004. How do crop plants tolerate acid soils? Mechanisms of aluminium tolerance and phosphorous efficiency. Annual Review of Plant Biology 55 (1):459–93. doi: 10.1146/annurev.arplant.55.031903.141655.
   PubMedGoogle Scholar
• Krause, T., and B. Ness. 2017. Energizing agroforestry: Ilex guayusa as an additional commodity to diversify Amazonian agroforestry systems. International Journal of Biodiversity Science, Ecosystem Services & Management 13 (1):191–203. doi: 10.1080/21513732.2017.1303646.
   Google Scholar
• Krieger, D. R., D. S. Kalman, S. Feldman, L. Arnillas, D. Goldberg, O. Gisbert, and S. Nader. 2016. The safety, pharmacokinetics, and nervous system effects of two natural sources of caffeine in healthy adult males. Clinical and Translational Science 9 (5):246–51. doi: 10.1111/cts.12403.
   PubMed Web of Science ®Google Scholar
• Lewis, W. H., M. Elvin-Lewis, and M. C. Gnerre. 1987. Introduction to the ethnobotanical pharmacopeia of the Amazon Jivaro of Peru. In 14th International Botanical Congress, ed. A. J. M. Leeuwenberg, 5–35:96–103. Berlin: Pudoc.
   Google Scholar
• Lewis, W. H., E. J. Kennelly, G. N. Bass, H. J. Wedner, M. P. Elvin-Lewis, and W. D. Fast. 1991. Ritualistic use of the holly Ilex guayusa by Amazonian Jivaro Indians. Journal of Ethnopharmacology 33 (1–2):25–30. doi: 10.1016/0378-8741(91)90156-8.
   PubMed Web of Science ®Google Scholar
• Liang, Y.-R., C. Liu, L.-P. Xiang, and X.-Q. Zheng. 2015. Health benefits of theanine in green tea: a review. Tropical Journal of Pharmaceutical Research 14 (10):1943–9. doi: 10.4314/tjpr.v14i10.29.
   Web of Science ®Google Scholar
• Linck, V., I. M. de Sá, and E. Elisabetsky. 2014. Yerba mate or Paraguay tea. Chinese Herbal Medicine 6 (3):253–4. doi: 10.1016/S1674-6384(14)60037-X.
   Google Scholar
• Loesener, L. E. T. 1901. Ilex guayusa. Nova Acta Academiae Caesareae Leopoldino-Carolinae Germanicae Naturae Curiosorum 78:310–1.
   Google Scholar
• Loizeau, P.-A. 1994. Les Aquifoliaceae Péruviennes (Éléments Pour Une Révision Des Aquifoliaceae Néotropicales). Boissiera. vol. 48. Geneva, Switzerland: Genève: Editions des Conservatoire et Jardin botaniques.
   Google Scholar
• Marcelo, M. C. A., C. A. Martins, D. Pozebon, V. L. Dressler, and M. F. Ferrão. 2014. Classification of yerba mate (Ilex paraguariensis) according to the country of origin based on element concentrations. Microchemical Journal 117:164–71. doi: 10.1016/j.microc.2014.06.027.
   Web of Science ®Google Scholar
• Marles, R. J., and N. R. Farnsworth. 1995. Antidiabetic plants and their active constituents. Phytomedicine 2 (2):137–89. doi: 10.1016/S0944-7113(11)80059-0.
   PubMed Web of Science ®Google Scholar
• McClatchey, W. C., G. B. Mahady, B. C. Bennett, L. Shiels, and V. Savo. 2009. Ethnobotany as a pharmacological research tool and recent developments in CNS-active natural products from ethnobotanical sources. Pharmacology and Therapeutics 123 (2):239–54. doi: 10.1016/j.pharmthera.2009.04.002.
   PubMed Web of Science ®Google Scholar
• Melo Gallegos, V. A. 2014. Composición y análisis químico de la especie Ilex guayusa Loes. Colegio de Ciencias e Ingeniería. Quito, Ecuador: Universidad San Francisco de Quito.
   Google Scholar
• Ministerio de Cultura y Patrimonio. 2016. Guayusa. Accessed December 29, 2018. http://patrimonioalimentario.culturaypatrimonio.gob.ec/wiki/index.php/Guayusa.
   Google Scholar
• Mohammed, M. I., and M. A. Sulaiman. 2009. Proximate, caffeine and tannin analyses in some brands of tea consumed in Kano metropolis, Nigeria. Bayero Journal of Pure and Applied Sciences 2 (2):19–21.
   Google Scholar
• Moldoveanu, S. C., and W. A. Scott. 2016. Analysis of four pentacyclic triterpenoid acids in several bioactive botanicals with gas and liquid chromatography and mass spectrometry detection. Journal of Separation Science 39 (2):324–32. doi: 10.1002/jssc.201501041.
   PubMed Web of Science ®Google Scholar
• Moldoveanu, S. C., J. Zhu, and N. Qian. 2015. Free amino acids analysis by liquid chromatography with tandem mass spectrometry in several botanicals with antioxidant character. Journal of Separation Science 38 (13):2208–22. doi: 10.1002/jssc.201500162.
   PubMed Web of Science ®Google Scholar
• Moldoveanu, S., W. Scott, and J. Zhu. 2015. Analysis of small carbohydrates in several bioactive botanicals by gas chromatography with mass spectrometry and liquid chromatography with tandem mass spectrometry. Journal of Separation Science 38 (21):3677–86. doi: 10.1002/jssc.201500573.
   PubMed Web of Science ®Google Scholar
• Montagnini, F., and P. K. R. Nair. 2004. Carbon sequestration: an underexploited environmental benefit of agroforestry systems. Agroforestry Systems 61–62 (1–3):281–95. doi: 10.1023/B:AGFO.0000029005.92691.79.
   Web of Science ®Google Scholar
• Nielsen, S. P. 2004. The biological role of strontium. Bone 35 (3):583–8. doi:10.1016/j.bone.2004.04.026.
   PubMed Web of Science ®Google Scholar
• Novel Foods. 2015. Regulation (EU) 2015/2283 of the European Parliament and of the Council of 25 November 2015 on novel foods, amending Regulation (EU) No 1169/2011 of the European Parliament and of the Council and repealing Regulation (EC) No 258/97 of the European Parliam. (EU) 2015/2283.
   Google Scholar
• Ozdemir, Feramuz, H. Y. Gökalp, and S. Nas. 1993. Effects of shooting period, times within shooting periods and processing systems on the extract, caffeine and crude fiber contents of black tea. Zeitschrift fur Lebensmittel-Untersuchung Und -Forschung 197 (4):358–62. doi: 10.1007/BF01242061.
   PubMedGoogle Scholar
• Pardau, M. D., A. S. P. Pereira, Z. Apostolides, J. C. Serem, and M. J. Bester. 2017. Antioxidant and anti-inflammatory properties of Ilex guayusa tea preparations: a comparison to Camellia sinensis teas. Food & Function 8 (12):4601. doi: 10.1039/C7FO01067B.
   PubMed Web of Science ®Google Scholar
• Patiño, V. M. 1968. Guayusa, a neglected stimulant from the Eastern Andean foothills. Economic Botany 22 (4):311–6. doi:10.1007/BF02908125.
   Web of Science ®Google Scholar
• Radice, M., and G. Vidari. 2007. Caracterización fitoquímica de la especie Ilex guayusa Loes. y elaboración de un prototipo de fitofármaco de interés comercial. La Granja 6 (2):3–11. doi: 10.17163/lgr.n6.2007.01.
   Google Scholar
• Ramachandran Nair, P., V. D. Nair, K. B. Mohan, and J. M. Showalter. 2010. Chapter five – Carbon sequestration in agroforestry systems. In Advances in agronomy, ed. D. L. Sparks, 108:237–307. Cambridge, MA: Academic Press. doi: 10.1016/S0065-2113(10)08005-3.
   Google Scholar
• Ramdani, D., A. S. Chaudhry, and C. J. Seal. 2013. Chemical composition, plant secondary metabolites, and minerals of green and black teas and the effect of different tea-to-water ratios during their extraction on the composition of their spent leaves as potential additives for ruminants. Journal of Agricultural and Food Chemistry 61 (20):4961–7. doi: 10.1021/jf4002439.
   PubMed Web of Science ®Google Scholar
• Riachi, L. G., and C. A. B. de Maria. 2017. Yerba mate: an overview of physiological effects in humans. Journal of Functional Foods 38:308–20. doi: 10.1016/j.jff.2017.09.020.
   Web of Science ®Google Scholar
• Russo, E. B. 1992. Headache treatments by native peoples of the Ecuadorian Amazon: a preliminary cross-disciplinary assessment. Jounrnal of Ethnopharmacology 36 (3):193–206. doi: 10.1016/0378-8741(92)90044-R.
   PubMed Web of Science ®Google Scholar
• Saltos, R. V. A., T. E. R. Vásquez, J. Alonso Lazo, D. V. Banguera, P. D. R. Guayasamín, J. K. A. Vargas, and I. V. Peñas. 2016. The use of medicinal plants by rural populations of the Pastaza province in the Ecuadorian Amazon. Acta Amazonica 46 (4):355–66. doi: 10.1590/1809-4392201600305.
   Web of Science ®Google Scholar
• Schultes, R. E. 1972. Ilex guayusa from 500 A.D. to the present. In A medicine-man' s implements and plants in a Tiahuanacoid tomb in highland Bolivia, ed. S. H. Wassen, 32:115–38. Goteborg: Goteborgs Ethnografiska Museum.
   Google Scholar
• Schultes, R. E. 1979. Discovery of an ancient guayusa plantation in Colombia. Botanical Museum Leaflets 27 (5–6):143–53.
   Google Scholar
• Schultes, R. E., and R. Raffauf. 1990. The healing forest: Medicinal and toxic plants of the Northwest Amazonia. Portland, OR: Dioscorides Press.
   Google Scholar
• Scientific Committee for Food. 1998. Opinion on the potential micro-biological risk arising from the presence of moisture in tea (expressed on 19th September 1997). Reports of the scientific committee for food (44th series). Belgium: Directorate-General for Consumer Policy and Consumer Health Protection.
   Google Scholar
• Sequeda-Castañeda, L. G., G. Modesti Costa, C. Celis, F. Gamboa, S. Gutiérrez, and P. Luengas. 2016. Ilex guayusa Loes. (Aquifoliaceae): Amazon and Andean native plant. Pharmacologyonline 3:193–202.
   Google Scholar
• Serra, J. de S. G. 1956. Maravillas del peril. Biblioteca Presidencia de la Republica 28–29 (1-2 and 3-4):423–60.
   Google Scholar
• Sidali, K. L., P. Y. Morocho, and E. I. Garrido-Pérez. 2016. Food tourism in indigenous settings as a strategy of sustainable development: the case of Ilex guayusa Loes. The Ecuadorian Amazon. Sustain 8 (10):967. doi: 10.3390/su8100967.
   Web of Science ®Google Scholar
• Spruce, R., and A. R. Wallace. 1908. Notes of a botanist on the Amazon and Andes: Being records of travel on the Amazon and its tributaries, the Trombetas, Rio Negro, Uaupés, Casiquiari, Pacimoni, Huallaga, and Pastasa; as also to the cataracts of the Orinoco, along the Eastern side of the Andes of Peru and Ecuador, and the shores of the Pacific, during the years 1849–1864. Vol. 2. London: Macmillan and Company.
   Google Scholar
• Stevens, P. F. 2017. Angiosperm Phylogeny Website, Version 14. Accessed January 3, 2019. http://www.mobot.org/MOBOT/research/APweb/
   Google Scholar
• Swanston-Flatt, S. K., C. Day, P. R. Flatt, B. J. Gould, and C. J. Bailey. 1989. Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetes Res 10 (2):69–73.
   PubMedGoogle Scholar
• Szymczycha-Madeja, A., M. Welna, and P. Pohl. 2012. Elemental analysis of teas and their infusions by spectrometric methods. Trends in Analytical Chemistry 35:165–81. doi: 10.1016/j.trac.2011.12.005.
   Web of Science ®Google Scholar
• Tea and Herbal Infusions Europe. 2014. Compendium of guidelines for tea (Camellia sinensis). Hamberg. Germany: Tea and Herbal Infusions Europe.
   Google Scholar
• Tene, V., O. Malagón, P. V. Finzi, G. Vidari, C. Armijos, and T. Zaragoza. 2007. An ethnobotanical survey of medicinal plants used in Loja and Zamora-Chinchipe, Ecuador. Journal of Ethnopharmacology 111 (1):63–81. doi: 10.1016/j.jep.2006.10.032.
   PubMed Web of Science ®Google Scholar
• Tscharntke, T., C. H. Sekercioglu, T. V. Dietsch, N. S. Sodhi, P. Hoehn, and J. M. Tylianakis. 2008. Landscape constraints on functional diversity of birds and insects in tropical agroecosystems. Ecology 89 (4):944–51. doi: 10.1890/07-0455.1.
   PubMed Web of Science ®Google Scholar
• Tsongas, T. A., R. R. Meglen, P. A. Walravens, and W. R. Chappell. 1980. Molybdenum in the diet: an estimate of average daily intake in the United States. The American Journal of Clinical Nutrition 33 (5):1103–07. doi: 10.1093/ajcn/33.5.1103.
   PubMed Web of Science ®Google Scholar
• Turck, D., J.-L. Bresson, B. Burlingame, T. Dean, S. Fairweather-Tait, M. Heinonen, and K. I. Hirsch-Ernst. 2016. Guidance on the preparation and presentation of the notification and application for authorisation of traditional foods from third countries in the context of regulation (EU) 2015/2283. EFSA J 14 (11):4590–605. doi: 10.2903/j.efsa.2016.4590.
   Web of Science ®Google Scholar
• Villacís-Chiriboga, J., A. García-Ruiz, N. Baenas, D. A. Moreno, A. J. Meléndez-Martínez, C. M. Stinco, L. Jerves-Andrade, F. León-Tamariz, J. Ortiz-Ulloa, and J. Ruales. 2018. Changes in phytochemical composition, bioactivity and in vitro digestibility of guayusa leaves (Ilex guayusa Loes.) in different ripening stages. Journal of the Science of Food and Agriculture 98 (5):1927–34. doi: 10.1002/jsfa.8675.
   PubMed Web of Science ®Google Scholar
• Werkhoven, J. 1974. Tea processing. FAO agricultural services bulletin. Rome: Food and Agricultural Organization of the United Nations.
   Google Scholar
• Wise, G., and D. E. Santander. 2018a. Assessing the history of safe use of guayusa. Journal of Food and Nutrition Research 6 (7):471–5. 6-7-8. doi: 10.12691/jfnr.
   Google Scholar
• Wise, G., and D. E. Santander. 2018b. Novel food notification for authorisation of a traditional food from a third country under regulation (EU) 2015/2283: Dried leaves of guayusa (Ilex guayusa Loes.). Tena, Ecuador: Ikiam EP. doi: 10.13140/RG.2.2.18400.53762.
   Google Scholar
• Wise, G., and D. E. Santander. 2018c. Comparative composition analysis of dried leaves of Ilex guayusa (Loes.). Journal of Food and Nutrition Research 6 (10):638–44. doi: 10.12691/jfnr-6-10-4.
   Google Scholar
• Yokogoshi, H., M. Kobayashi, M. Mochizuki, and T. Terashima. 1998. Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Neurochemical Research 23 (5):667–73.
   PubMed Web of Science ®Google Scholar
• Yokogoshi, H., M. Mochizuki, and K. Saitoh. 1998. Theanine-induced reduction of brain serotonin concentration in rats. Bioscience, Biotechnology, and Biochemistry 62 (4):816–7. doi: 10.1271/bbb.62.816.
   PubMed Web of Science ®Google Scholar