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The effects and associations of whole-apple intake on diverse cardiovascular risk factors. A narrative review

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References

  • Alissa, E. M., and G. A. Ferns. 2017. Dietary fruits and vegetables and cardiovascular diseases risk. Critical Reviews in Food Science and Nutrition 57 (9):1950–62. doi: 10.1080/10408398.2015.1040487.
  • Arts, I. C., D. R. Jacobs, L. J. Harnack, M. Gross, and A. R. Folsom. 2001. Dietary catechins in relation to coronary heart disease death among postmenopausal women. Epidemiology (Cambridge, MA) 12 (6):668–75. http://www.ncbi.nlm.nih.gov/pubmed/11679795. doi: 10.1097/00001648-200111000-00015.
  • Asghar, A., and N. Sheikh. 2017. Role of immune cells in obesity induced low grade inflammation and insulin resistance. Cellular Immunology 315:18–26. doi: 10.1016/j.cellimm.2017.03.001.
  • Auclair, S., G. Chironi, D. Milenkovic, P. C. H. Hollman, C. M. G. C. Renard, J. L. Mégnien, J. Gariepy, J. L. Paul, A. Simon, and A. Scalbert. 2010. The regular consumption of a polyphenol-rich apple does not influence endothelial function: A randomised double-blind trial in hypercholesterolemic adults. European Journal of Clinical Nutrition 64 (10):1158–65. doi: 10.1038/ejcn.2010.135.
  • Aune, D., E. Giovannucci, P. Boffetta, L. T. Fadnes, N. N. Keum, T. Norat, D. C. Greenwood, E. Riboli, L. J. Vatten, and S. Tonstad. 2017. Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality-a systematic review and dose-response meta-analysis of prospective studies. International Journal of Epidemiology 46 (3):1029–56. doi: 10.1093/ije/dyw319.
  • Bondonno, C. P., X. Yang, K. D. Croft, M. J. Considine, N. C. Ward, L. Rich, I. B. Puddey, E. Swinny, A. Mubarak, and J. M. Hodgson. 2012. Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: A randomized controlled trial. Free Radical Biology and Medicine 52 (1):95–102. doi: 10.1016/j.freeradbiomed.2011.09.028.
  • Bondonno, N. P., C. P. Bondonno, L. C. Blekkenhorst, M. J. Considine, G. Maghzal, R. Stocker, R. J. Woodman, N. C. Ward, J. M. Hodgson, and K. D. Croft. 2018. Flavonoid-rich apple improves endothelial function in individuals at risk for cardiovascular disease: A randomized controlled clinical trial. Molecular Nutrition & Food Research 62 (3):1700674. doi: 10.1002/mnfr.201700674.
  • Bondonno, N., J. Lewis, R. Prince, W. Lim, G. Wong, J. Schousboe, R. Woodman, D. Kiel, C. Bondonno, N. Ward, et al. 2016. Fruit intake and abdominal aortic calcification in elderly women: A prospective cohort study. Nutrients 8 (3):159. doi: 10.3390/nu8030159.
  • Borgi, L., I. Muraki, A. Satija, W. C. Willett, E. B. Rimm, and J. P. Forman. 2016. Fruit and vegetable consumption and the incidence of hypertension in three prospective cohort studies. Hypertension 67 (2):288–93. doi: 10.1161/HYPERTENSIONAHA.115.06497.
  • Chai, S. C., S. Hooshmand, R. L. Saadat, M. E. Payton, K. Brummel-Smith, and B. H. Arjmandi. 2012. Daily apple versus dried plum: Impact on cardiovascular disease risk factors in postmenopausal women. Journal of the Academy of Nutrition and Dietetics 112 (8):1158–68. doi: 10.1016/j.jand.2012.05.005.
  • Chun, O. K., S.-J. Chung, K. J. Claycombe, and W. O. Song. 2008. Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults. The Journal of Nutrition 138 (4):753–60. doi: 10.1093/jn/138.4.753.
  • Collese, T. S., M. V. Nascimento-Ferreira, A. C. F. de Moraes, T. Rendo-Urteaga, S. Bel-Serrat, L. A. Moreno, and H. B. Carvalho. 2017. Role of fruits and vegetables in adolescent cardiovascular health: A systematic review. Nutrition Reviews 75 (5):339–49. doi: 10.1093/nutrit/nux002.
  • Corte, V. D., A. Tuttolomondo, R. Pecoraro, D. Di Raimondo, V. Vassallo, and A. Pinto. 2016. Inflammation, endothelial dysfunction and arterial stiffness as therapeutic targets in cardiovascular medicine. Current Pharmaceutical Design 22 (30):4658–68. doi: 10.2174/1381612822666160510124801.
  • Cusack, L. K., M. L. Fernandez, and J. S. Volek. 2013. The food matrix and sterol characteristics affect the plasma cholesterol lowering of phytosterol/phytostanol. Advances in Nutrition 4 (6):633–43. doi: 10.3945/an.113.004507.
  • Daiber, A., S. Steven, A. Weber, V. V. Shuvaev, V. R. Muzykantov, I. Laher, H. Li, S. Lamas, and T. Münzel. 2017. Targeting vascular (endothelial) dysfunction. British Journal of Pharmacology 174 (12):1591–619. doi: 10.1111/bph.13517.
  • Dias, T., P. Oliveira, S. Casal, M. Alves, and B. Silva. 2017. Promising potential of dietary (poly)phenolic compounds in the prevention and treatment of diabetes mellitus. Current Medicinal Chemistry 24 (4):334–54. doi: 10.2174/0929867323666160905150419.
  • Ettehad, D., C. A. Emdin, A. Kiran, S. G. Anderson, T. Callender, J. Emberson, J. Chalmers, A. Rodgers, and K. Rahimi. 2016. Blood pressure lowering for prevention of cardiovascular disease and death: A systematic review and meta-analysis. The Lancet 387 (10022):957–67. doi: 10.1016/S0140-6736(15)01225-8.
  • Ferrari, R. 2015. Writing narrative style literature reviews. Medical Writing 24 (4):230–5. doi: 10.1179/2047480615Z.000000000329.
  • Gerhauser, C. 2008. Cancer Chemopreventive potential of apples, apple juice, and apple components. Planta Medica 74 (13):1608–24. doi: 10.1055/s-0028-1088300.
  • Gimbrone, M. A., and G. García-Cardeña. 2016. Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circulation Research 118 (4):620–36. doi: 10.1161/CIRCRESAHA.115.306301.
  • Gleize, B., M. Nowicki, C. Daval, H. Koutnikova, and P. Borel. 2016. Form of phytosterols and food matrix in which they are incorporated modulate their incorporation into mixed micelles and impact cholesterol micellarization. Molecular Nutrition & Food Research 60 (4):749–59. doi: 10.1002/mnfr.201500586.
  • Goldstein, J. L., and M. S. Brown. 2015. A century of cholesterol and coronaries: From plaques to genes to statins. Cell 161 (1):161–72. doi: 10.1016/j.cell.2015.01.036.
  • Gormley, T. R., J. Kevany, J. P. Egan, and R. McFarlane. 1977. Effect of apples on serum cholesterol levels in humans. Irish Journal of Food Science and Technology 1:117–28. 10.2307/25557940.
  • Grandl, G., and C. Wolfrum. 2018. Hemostasis, endothelial stress, inflammation, and the metabolic syndrome. Seminars in Immunopathology 40 (2):215–24. doi: 10.1007/s00281-017-0666-5.
  • Green, B. N., C. D. Johnson, and A. Adams. 2006. Writing narrative literature reviews for peer-reviewed journals: Secrets of the trade. Journal of Chiropractic Medicine 5 (3):101–17. doi: 10.1016/S0899-3467(07)60142-6.
  • Grundy, S. M., N. J. Stone, A. L. Bailey, C. Beam, K. K. Birtcher, R. S. Blumenthal, L. T. Braun, S. de Ferranti, J. Faiella-Tommasino, D. E. Forman, et al. 2019. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the management of blood cholesterol: Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal of the American College of Cardiology 73 (24):3168–209. doi: 10.1016/j.jacc.2018.11.002.
  • Guarner, V., and M. E. Rubio-Ruiz. 2015. Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease. Interdisciplinary Topics in Gerontology 40:99–106. doi: 10.1159/000364934.
  • Guasch-Ferré, M., J. Merino, Q. Sun, M. Fitó, and J. Salas-Salvadó. 2017. Dietary polyphenols, mediterranean diet, prediabetes, and type 2 diabetes: A narrative review of the evidence. Oxidative Medicine and Cellular Longevity 2017:1–16. doi: 10.1155/2017/6723931.
  • GutiErrez-Grijalva, E. P., D. L. Ambriz-Pere, N. Leyva-Lopez, R. I. Castillo-Lopez, and J. B. Heiedia. 2016. Review: Dietary phenolic compounds, health benefits and bioaccessibility. Archivos Latinoamericanos de Nutricion 66 (2):87–100. http://www.ncbi.nlm.nih.gov/pubmed/29737665.
  • Guzik, T. J., and R. M. Touyz. 2017. Oxidative stress, inflammation, and vascular aging in hypertension. Hypertension 70 (4):660–7. doi: 10.1161/HYPERTENSIONAHA.117.07802.
  • Hansen, L., L. O. Dragsted, A. Olsen, J. Christensen, A. Tjønneland, E. B. Schmidt, and K. Overvad. 2010. Fruit and vegetable intake and risk of acute coronary syndrome. British Journal of Nutrition 104 (2):248–55. doi: 10.1017/S0007114510000462.
  • Hébert, J. R., E. A. Frongillo, S. A. Adams, G. M. Turner-McGrievy, T. G. Hurley, D. R. Miller, and I. S. Ockene. 2016. Perspective: Randomized controlled trials are not a panacea for diet-related research. Advances in Nutrition 7 (3):423–32. doi: 10.3945/an.115.011023.
  • Higgins, J. P. T., D. G. Altman, P. C. Gøtzsche, P. Jüni, D. Moher, A. D. Oxman, J. Savović, K. F. Schulz, L. Weeks, and J. A. C. Sterne. 2011. The Cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ (Online) 343 (7829):d5928–d5928. doi: 10.1136/bmj.d5928.
  • Hodgson, J. M., R. L. Prince, R. J. Woodman, C. P. Bondonno, K. L. Ivey, N. Bondonno, E. B. Rimm, N. C. Ward, K. D. Croft, and J. R. Lewis. 2016. Apple intake is inversely associated with all-cause and disease-specific mortality in elderly women. British Journal of Nutrition 115 (5):860–7. doi: 10.1017/S0007114515005231.
  • Homan, T. D., and E. Cichowski. 2019. Physiology, pulse pressure. StatPearls. http://www.ncbi.nlm.nih.gov/pubmed/29494015.
  • Hyson, D. A. 2011. A comprehensive review of apples and apple components and their relationship to human health. Advances in Nutrition 2 (5):408–20. doi: 10.3945/an.111.000513.
  • James, J. E. 2017. Hypertension control and cardiovascular disease. The Lancet 389 (10065):154. doi: 10.1016/S0140-6736(17)30018-1.
  • Joseph, P., D. Leong, M. McKee, S. S. Anand, J.-D. Schwalm, K. Teo, A. Mente, and S. Yusuf. 2017. Reducing the global burden of cardiovascular disease, Part 1. Circulation Research 121 (6):677–94. doi: 10.1161/CIRCRESAHA.117.308903.
  • Kalinowska, M., A. Bielawska, H. Lewandowska-Siwkiewicz, W. Priebe, and W. Lewandowski. 2014. Apples: Content of phenolic compounds vs. variety, part of apple and cultivation model, extraction of phenolic compounds, biological properties. Plant Physiology and Biochemistry 84:169–88. doi: 10.1016/j.plaphy.2014.09.006.
  • Knekt, P., H. Rissanen, M. Heliövaara, A. Reunanen, A. Aromaa, J. Kumpulainen, R. Järvinen, and T. Hakulinen. 2002. Flavonoid intake and risk of chronic diseases. The American Journal of Clinical Nutrition 76 (3):560–8. doi: 10.1093/ajcn/76.3.560.
  • Liddle, D., X. (L.). Lin, L. Cox, E. Ward, K. Power, A. Wright, and L. Robinson. 2019. Assessing the effects of acute and chronic whole apple consumption on biomarkers of inflammation in overweight and obese adults (P21-011-19). Current Developments in Nutrition 3 (Suppl_1):1842. doi: 10.1093/cdn/nzz041.P21-011-19.
  • Mari, A., I. Tedesco, A. Nappo, G. L. Russo, A. Malorni, and V. Carbone. 2010. Phenolic compound characterisation and antiproliferative activity of ‘annurca’ apple, a Southern Italian Cultivar. Food Chemistry 123 (1):157–64. doi: 10.1016/j.foodchem.2010.04.023.
  • Martínez-González, M. A., J. Salas-Salvadó, R. Estruch, D. Corella, M. Fitó, and E. Ros. 2015. Benefits of the Mediterranean diet: Insights from the PREDIMED study. Progress in Cardiovascular Diseases 58 (1):50–60. doi: 10.1016/j.pcad.2015.04.003.
  • Matsuzawa, Y., R. R. Guddeti, T.-G. Kwon, L. O. Lerman, and A. Lerman. 2015. Secondary prevention strategy of cardiovascular disease using endothelial function testing. Circulation Journal 79 (4):685–94. doi: 10.1253/circj.CJ-15-0068.
  • Miller, M. G., N. Thangthaeng, S. M. Poulose, and B. Shukitt-Hale. 2017. Role of fruits, nuts, and vegetables in maintaining cognitive health. Experimental Gerontology 94 (August):24–8. doi: 10.1016/j.exger.2016.12.014.
  • Miller, V., A. Mente, M. Dehghan, S. Rangarajan, X. Zhang, S. Swaminathan, G. Dagenais, R. Gupta, V. Mohan, S. Lear, et al. 2017. Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): A prospective cohort study. The Lancet 390 (10107):2037–49. doi: 10.1016/S0140-6736(17)32253-5.
  • Minihane, A. M., S. Vinoy, W. R. Russell, A. Baka, H. M. Roche, K. M. Tuohy, J. L. Teeling, E. E. Blaak, M. Fenech, D. Vauzour, et al. 2015. Low-grade inflammation, diet composition and health: Current research evidence and its translation. British Journal of Nutrition 114 (7):999–1012. doi: 10.1017/S0007114515002093.
  • Mink, P. J., C. G. Scrafford, L. M. Barraj, L. Harnack, C. P. Hong, J. A. Nettleton, and D. R. Jacobs. 2007. Flavonoid intake and cardiovascular disease mortality: A prospective study in postmenopausal women. The American Journal of Clinical Nutrition 85 (3):895–909. doi: 10.1093/ajcn/85.3.895.
  • Moher, D., A. Liberati, J. Tetzlaff, and D. G. Altman. and PRISMA Group. 2009. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine 6 (7):e1000097. doi: 10.1371/journal.pmed.1000097.
  • National Institutes of Health. 2014. “Study Quality Assessment Tools | National Heart, Lung, and Blood Institute (NHLBI).” National Institutes of Health. 2014. https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools.
  • Onor, I. C. O., D. L. Stirling, S. R. Williams, D. Bediako, A. Borghol, M. B. Harris, T. B. Darensburg, S. D. Clay, S. C. Okpechi, and D. F. Sarpong. 2017. Clinical effects of cigarette smoking: Epidemiologic impact and review of pharmacotherapy options. International Journal of Environmental Research and Public Health 14 (10):1147. doi: 10.3390/ijerph14101147.
  • Ravn-Haren, G., L. O. Dragsted, T. Buch-Andersen, E. N. Jensen, R. I. Jensen, M. Németh-Balogh, B. Paulovicsová, A. Bergström, A. Wilcks, T. R. Licht, et al. 2013. Intake of whole apples or clear apple juice has contrasting effects on plasma lipids in healthy volunteers. European Journal of Nutrition 52 (8):1875–89. doi: 10.1007/s00394-012-0489-z.
  • Schulz, K. F., D. C. Altman, and D. Moher. 2010. CONSORT 2010 Statement: Updated guidelines for reporting parallel group randomised trials. Italian Journal of Public Health 7 (3):325–32. doi: 10.1136/bmj.c332.
  • Slavin, J. L., and B. Lloyd. 2012. Health benefits of fruits and vegetables. Advances in Nutrition 3 (4):506–16. doi: 10.3945/an.112.002154.
  • Stirpe, M., V. Palermo, M. M. Bianchi, R. Silvestri, C. Falcone, G. Tenore, E. Novellino, and C. Mazzoni. 2017. Annurca apple (M. Pumila Miller Cv Annurca) extracts act against stress and ageing in S. Cerevisiae yeast cells. BMC Complementary and Alternative Medicine 17 (1):200. doi: 10.1186/s12906-017-1666-7.
  • Tenore, G. C., D. Caruso, G. Buonomo, E. D'Urso, M. D'Avino, P. Campiglia, L. Marinelli, and E. Novellino. 2017. Annurca (Malus Pumilamiller Cv. Annurca) apple as a functional food for the contribution to a healthy balance of plasma cholesterol levels: results of a randomized clinical trial. Journal of the Science of Food and Agriculture 97 (7):2107–15. doi: 10.1002/jsfa.8016.
  • Vafa, M. R., E. Haghighatjoo, F. Shidfar, S. Afshari, M. Reza Gohari, and A. Ziaee. 2011. Effects of apple consumption on lipid profile of hyperlipidemic and overweight men. International Journal of Preventive Medicine 2 (2):94–100. http://www.ncbi.nlm.nih.gov/pubmed/21603015.
  • Veronese, N., M. Solmi, M. G. Caruso, G. Giannelli, A. R. Osella, E. Evangelou, S. Maggi, L. Fontana, B. Stubbs, and I. Tzoulaki. 2018. Dietary fiber and health outcomes: An umbrella review of systematic reviews and meta-analyses. American Journal of Clinical Nutrition 107 (3):436–44. doi: 10.1093/ajcn/nqx082.
  • Wang, N., S. Jiang, Z. Zhang, H. Fang, H. Xu, Y. Wang, and X. Chen. 2018. Malus sieversii: The origin, flavonoid synthesis mechanism, and breeding of red-skinned and red-fleshed apples. Horticulture Research 5 (1):70. doi: 10.1038/s41438-018-0084-4.
  • Warburton, D. E. R., and S. S. D. Bredin. 2017. Health benefits of physical activity: A systematic review of current systematic reviews. Current Opinion in Cardiology 32 (5):541–56. doi: 10.1097/HCO.0000000000000437.