Nutritive vitamins as epidrugs

References

• Agger, K., P.A. Cloos, J. Christensen, D. Pasini, S. Rose, J. Rappsilber, I. Issaeva, E. Canaani, A. E. Salcini, and K. Helin. 2007. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 449 (7163):731–4. doi: 10.1038/nature06145.
   PubMed Web of Science ®Google Scholar
• Anderson, C. M., S. L. Gillespie, D. K. Thiele, J. L. Ralph, and J. E. Ohm. 2018. Effects of maternal vitamin D supplementation on the maternal and infant epigenome. Breastfeeding Medicine 13 (5):371–80. doi: 10.1089/bfm.2017.0231.
   PubMed Web of Science ®Google Scholar
• Arts, R. J., B. A. Blok, R. van Crevel, L. A. Joosten, P. Aaby, C. S. Benn, and M. G. Netea. 2015. Vitamin A induces inhibitory histone methylation modifications and down-regulates trained immunity in human monocytes. Journal of Leukocyte Biology 98 (1):129–36. doi: 10.1189/jlb.6AB0914-416R.
   PubMed Web of Science ®Google Scholar
• Beckett, E. L., M. Veysey, and M. Lucock. 2017. Folate and microRNA: Bidirectional interactions. Clinica Chimica Acta 474:60–6. doi: 10.1016/j.cca.2017.09.001.
   PubMed Web of Science ®Google Scholar
• Bikle, D. D. 2014. Vitamin D metabolism, mechanism of action, and clinical applications. Chemistry & Biology 21 (3):319–29. doi: 10.1016/j.chembiol.2013.12.016.
   PubMedGoogle Scholar
• Binda, O., A. Sevilla, G. LeRoy, I. R. Lemischka, B. A. Garcia, and S. Richard. 2013. SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal. Epigenetics 8 (2):177–83. doi: 10.4161/epi.23416.
   PubMed Web of Science ®Google Scholar
• Bird, A. 2002. DNA methylation patterns and epigenetic memory. Genes & Development 16 (1):6–21. doi: 10.1101/gad.947102.
   PubMed Web of Science ®Google Scholar
• Blaschke, K., K. T. Ebata, M. M. Karimi, J. A. Zepeda-Martinez, P. Goyal, S. Mahapatra, A. Tam, D. J. Laird, M. Hirst, A. Rao, et al. 2013. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature 500 (7461):222–6. doi: 10.1038/nature12362.
   PubMed Web of Science ®Google Scholar
• Bocker, M. T., F. Tuorto, G. Raddatz, T. Musch, F.-C. Yang, M. Xu, F. Lyko, and A. Breiling. 2012. Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster. Nature Communications 3 (1):818. doi: 10.1038/ncomms1826.
   PubMedGoogle Scholar
• Camarena, V., and G. Wang. 2016. The epigenetic role of vitamin C in health and disease. Cellular and Molecular Life Sciences 73 (8):1645–58. doi: 10.1007/s00018-016-2145-x.
   PubMed Web of Science ®Google Scholar
• Carlberg, C., and S. Seuter. 2009. A genomic perspective on vitamin D signaling. Anticancer Research 29 (9):3485–349.
   PubMed Web of Science ®Google Scholar
• Carlos-Reyes, Á., J. S. López-González, M. Meneses-Flores, D. Gallardo-Rincón, E. Ruíz-García, L. A. Marchat, H. Astudillo-de la Vega, O. N. Hernández de la Cruz, and C. López-Camarillo. 2019. Dietary compounds as epigenetic modulating agents in cancer. Frontiers in Genetics 10:791. doi: 10.3389/fgene.2019.00079. eCollection
   PubMed Web of Science ®Google Scholar
• Cerami, E., J. Gao, U. Dogrusoz, B. E. Gross, S. O. Sumer, B. A. Aksoy, A. Jacobsen, C. J. Byrne, M. L. Heuer, E. Larsson, et al. 2012. The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discovery 2 (5):401–4. doi: 10.1158/2159-8290.CD-12-0095.
   PubMed Web of Science ®Google Scholar
• Chen, D. J., L. J. Li, X. K. Yang, T. Yu, R. X. Leng, H. F. Pan, and D. Q. Ye. 2017. Altered microRNAs expression in T cells of patients with SLE involved in the lack of vitamin D. Oncotarget 8 (37):62099–110. doi: 10.18632/oncotarget.19062.
   PubMedGoogle Scholar
• Chen, J., L. Guo, L. Zhang, H. Wu, J. Yang, H. Liu, X. Wang, X. Hu, T. Gu, Z. Zhou, et al. 2013. Vitamin C modulates TET1 function during somatic cell reprogramming. Nature Genetics 45 (12):1504–9. doi: 10.1038/ng.2807.
   PubMed Web of Science ®Google Scholar
• Cheong, H. S., H. C. Lee, B. L. Park, H. Kim, M. J. Jang, Y. M. Han, S. Y. Kim, Y. S. Kim, and H. D. Shin. 2010. Epigenetic modification of retinoic acid-treated human embryonic stem cells. BMB Reports 43 (12):830–5. doi: 10.5483/BMBRep.2010.43.12.830.
   PubMed Web of Science ®Google Scholar
• Choi, S. W., and S. Friso. 2010. Epigenetics: A new bridge between nutrition and health. Advances in Nutrition 1 (1):8–16. doi: 10.3945/an.110.1004.
   PubMed Web of Science ®Google Scholar
• Cimmino, L., B. G. Neel, and I. Aifantis. 2018. Vitamin C in stem cell reprogramming and cancer. Trends in Cell Biology 28 (9):698–708. doi: 10.1016/j.tcb.2018.04.001.
   PubMed Web of Science ®Google Scholar
• Couturier, A., J. Keller, E. Most, R. Ringseis, and K. Eder. 2014. Niacin in pharmacological doses alters microRNA expression in skeletal muscle of obese Zucker rats. PLoS One 9 (5):e98313. doi: 10.1371/journal.pone.0098313.
   PubMed Web of Science ®Google Scholar
• Dadon, B. E. S., and R. Reifen. 2017. Vitamin A and the epigenome. Critical Reviews in Food Science and Nutrition 57 (11):2404–11. doi: 10.1080/10408398.2015.1060940.
   PubMed Web of Science ®Google Scholar
• Dambal, S., A. A. Giangreco, A. M. Acosta, A. Fairchild, Z. Richards, R. Deaton, D. Wagner, R. Vieth, P. H. Gann, A. Kajdacsy-Balla, et al. 2017. microRNAs and DICER1 are regulated by 1,25-dihydroxyvitamin D in prostate stroma. The Journal of Steroid Biochemistry and Molecular Biology 167:192–202. doi: 10.1016/j.jsbmb.2017.01.004.
   PubMed Web of Science ®Google Scholar
• Delhommeau, F., S. Dupont, V. Della Valle, C. James, S. Trannoy, A. Massé, O. Kosmider, J. P. Le Couedic, F. Robert, A. Alberdi, et al. 2009. Mutation in TET2 in myeloid cancers. New England Journal of Medicine 360 (22):2289–301. doi: 10.1056/NEJMoa0810069.
   PubMed Web of Science ®Google Scholar
• Doig, C. L., P. K. Singh, V. K. Dhiman, J. L. Thorne, S. Battaglia, M. Sobolewski, O. Maguire, L. P. O'Neill, B. M. Turner, C. J. McCabe, et al. 2013. Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns. Carcinogenesis 34 (2):248–56. doi: 10.1093/carcin/bgs331.
   PubMed Web of Science ®Google Scholar
• Doldo, E., G. Costanza, S. Agostinelli, C. Tarquini, A. Ferlosio, G. Arcuri, D. Passeri, M. G. Scioli, and A. Orlandi. 2015. Vitamin A, cancer treatment and prevention: The new role of cellular retinol binding proteins. BioMed Research International 2015:624627. doi: 10.1155/2015/624627.
   PubMed Web of Science ®Google Scholar
• Dragnev, K. H., J. R. Rigas, and E. Dmitrovsky. 2000. The retinoids and cancer prevention mechanisms. The Oncologist 5 (5):361–8. doi: 10.1634/theoncologist.5-5-361.
   PubMedGoogle Scholar
• Drouin, G., J. R. Godin, and B. Page. 2011. The genetics of vitamin C loss in vertebrates. Current Genomics 12 (5):371–8. doi: 10.2174/138920211796429736.
   PubMed Web of Science ®Google Scholar
• Ducasse, M., and M. A. Brown. 2006. Epigenetic aberrations and cancer. Molecular Cancer 5 (1):60. doi: 10.1186/1476-4598-5-60.
   PubMedGoogle Scholar
• Ebata, K. T., K. Mesh, S. Liu, M. Bilenky, A. Fekete, M. G. Acker, M. Hirst, B. A. Garcia, and M. Ramalho-Santos. 2017. Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b. Epigenetics & Chromatin 10:36. doi: 10.1186/s13072-017-0143-3.
   PubMed Web of Science ®Google Scholar
• Fan, P., L. He, N. Hu, J. Luo, J. Zhang, L. F. Mo, Y. H. Wang, D. Pu, X. H. Lv, Z. M. Hao, et al. 2017. Effect of 1,25-(OH)2D3 on proliferation of fibroblast-like synoviocytes and expressions of pro-inflammatory cytokines through regulating MicroRNA-22 in a rat model of rheumatoid arthritis. Cellular Physiology and Biochemistry 42 (1):145–55. doi: 10.1159/000477123.
   PubMedGoogle Scholar
• Fazi, F., L. Travaglini, D. Carotti, F. Palitti, D. Diverio, M. Alcalay, S. McNamara, W. H. Miller, F. L. Coco, P. G. Pelicci, et al. 2005. Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo. Oncogene 24 (11):1820–30. doi: 10.1038/sj.onc.1208286.
   PubMed Web of Science ®Google Scholar
• Feinberg, A. P. 2007. Phenotypic plasticity and the epigenetics of human disease. Nature 447 (7143):433–40. doi: 10.1038/nature05919.
   PubMed Web of Science ®Google Scholar
• Fernandez-Roig, S., S. C. Lai, M. M. Murphy, J. Fernandez-Ballart, and E. V. Quadros. 2012. Vitamin B12 deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse. Nutrition & Metabolism 9:41. doi: 10.1186/1743-7075-9-41.
   PubMed Web of Science ®Google Scholar
• Ferrari, N., U. Pfeffer, and G. Vidali. 1988. In vivo binding of retinol to chromatin. The binding is mediated by a lipoprotein. The Journal of Biological Chemistry 263 (1):448–53.
   PubMed Web of Science ®Google Scholar
• Fetahu, I. S., J. Hobaus, and E. Kallay. 2014. Vitamin D and the epigenome. Frontiers in Physiology 5:164. doi: 10.3389/fphys.2014.00164.
   PubMed Web of Science ®Google Scholar
• Friso, S., D. De Santis, F. Pizzolo, and S. Udali. 2020. Vitamins and epigenetics. Molecular Nutrition, 633–50. Cambridge, USA: Academic press. doi: 10.1016/B978-0-12-811907-5.00033-6.
   Google Scholar
• Friso, S., S. Udali, D. D. Santis, and S. W. Choi. 2017. One-carbon metabolism and epigenetics. Molecular Aspects of Medicine 54:28–36. doi: 10.1016/j.mam.2016.11.007.
   PubMed Web of Science ®Google Scholar
• Fu, B., H. Wang, J. Wang, I. Barouhas, W. Liu, A. Shuboy, D. A. Bushinsky, D. Zhou, and M. J. Favus. 2013. Epigenetic regulation of BMP2 by 1,25-dihydroxyvitamin D3 through DNA methylation and histone modification. PLoS One 8 (4):e61423. doi: 10.1371/journal.pone.0061423.
   PubMed Web of Science ®Google Scholar
• Gao, Y., Z. Han, Q. Li, Y. Wu, X. Shi, Z. Ai, J. Du, W. Li, Z. Guo, and Y. Zhang. 2015. Vitamin C induces a pluripotent state in mouse embryonic stem cells by modulating microRNA expression. The Febs Journal 282 (4):685–99. doi: 10.1111/febs.13173.
   PubMed Web of Science ®Google Scholar
• Geoffroy, A., R. Kerek, G. Pourie, D. Helle, J. L. Guéant, J. L. Daval, and C. Bossenmeyer-Pourié. 2017. Late maternal folate supplementation rescues from methyl donor deficiency-associated brain defects by restoring Let-7 and miR-34 pathways. Molecular Neurobiology 54 (7):5017–33. doi: 10.1007/s12035-016-0035-8.
   PubMed Web of Science ®Google Scholar
• Giangreco, A. A., and L. Nonn. 2013. The sum of many small changes: MicroRNAs are specifically and potentially globally altered by vitamin D3 metabolites. The Journal of Steroid Biochemistry and Molecular Biology 136:86–93. doi: 10.1016/j.jsbmb.2013.01.001.
   PubMed Web of Science ®Google Scholar
• Gillberg, L., A. D. Ørskov, A. Nasif, H. Ohtani, Z. Madaj, J. W. Hansen, N. Rapin, J. B. Mogensen, M. Liu, I. H. Dufva, et al. 2019 Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes. Clin Epigenetics 11(1):143. doi: 10.1186/s13148-019-0739-5.
   PubMed Web of Science ®Google Scholar
• Gille, D., and A. Schmid. 2015. Vitamin B12 in meat and dairy products. Nutrition Reviews 773 (2):106–15. doi: 10.1093/nutrit/nuu011.
   Google Scholar
• Gruber, B. M. 2016. B-Group vitamins: Chemoprevention?. Advances in Clinical and Experimental Medicine 25 (3):561–8. doi: 10.17219/acem/33847.
   PubMed Web of Science ®Google Scholar
• Gudas, L. J. 2013. Retinoids induce stem cell differentiation via epigenetic changes. Seminars in Cell & Developmental Biology 24 (10-12):701–5. doi: 10.1016/j.semcdb.2013.08.002.
   PubMed Web of Science ®Google Scholar
• Haberland, M., R. L. Montgomery, and E. N. Olson. 2009. The many roles of histone deacetylases in development and physiology: Implications for disease and therapy. Nature Reviews Genetics 10(1):32–42. doi: 10.1038/nrg2485.
   PubMed Web of Science ®Google Scholar
• Hassan, Y. I., and J. Zempleni. 2006. Epigenetic regulation of chromatin structure and gene function by biotin. The Journal of Nutrition 136 (7):1763–5. doi: 10.1093/jn/136.7.1763.
   PubMed Web of Science ®Google Scholar
• Haussler, M. R., P. W. Jurutka, M. Mizwicki, and A. W. Norman. 2011. Vitamin D receptor (VDR)-mediated actions of 1alpha,25(OH)(2)vitamin D(3): genomic and non-genomic mechanisms. Best Practice & Research Clinical Endocrinology & Metabolism 25 (4):543–59. doi: 10.1016/j.beem.2011.05.010.
   PubMed Web of Science ®Google Scholar
• He, L., and G. J. Hannon. 2004. MicroRNAs: Small RNAs with a big role in gene regulation. Nature Reviews Genetics 5 (7):522–31. doi: 10.1038/nrg1379.
   PubMed Web of Science ®Google Scholar
• Herceg, Z. 2007. Epigenetics and cancer: Towards an evaluation of the impact of environmental and dietary factors. Mutagenesis 22 (2):91–103. doi: 10.1093/mutage/gel068.
   PubMed Web of Science ®Google Scholar
• Hong, S., Y. W. Cho, L. R. Yu, H. Yu, T. D. Veenstra, and K. Ge. 2007. Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proceedings of the National Academy of Sciences of United States of America 104 (47):18439–44. doi: 10.1073/pnas.0707292104.
   PubMed Web of Science ®Google Scholar
• Hore, T. A. 2017. Modulating epigenetic memory through vitamins and TET: Implications for regenerative medicine and cancer treatment. Epigenomics 9 (6):863–71. doi: 10.2217/epi-2017-0021.
   PubMed Web of Science ®Google Scholar
• Horton, J. R., A. K. Upadhyay, H. H. Qi, X. Zhang, Y. Shi, and X. Cheng. 2010. Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nature Structural & Molecular Biology 17 (1):38–43. doi: 10.1038/nsmb.1753.
   PubMed Web of Science ®Google Scholar
• Hou, N., L. Ren, M. Gong, Y. Bi, Y. Gu, Z. Dong, Y. Liu, J. Chen, and T. Li. 2015. Vitamin A deficiency impairs spatial learning and memory: The mechanism of abnormal CBP-dependent histone acetylation regulated by retinoic acid receptor alpha. Molecular Neurobiology 51 (2):633–47. doi: 10.1007/s12035-014-8741-6.
   PubMed Web of Science ®Google Scholar
• Ito, S., A. C. D’Alessio, O. V. Taranova, K. Hong, L. C. Sowers, and Y. Zhang. 2010. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466 (7310):1129–33. doi: 10.1038/nature09303.
   PubMed Web of Science ®Google Scholar
• Jian, P., Z. W. Li, T. Y. Fang, W. Jian, Z. Zhuan, L.X. Mei, W.S. Yan, and N. Jian. 2011. Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663. Journal of Hematology & Oncology 4 (1):20. doi: 10.1186/1756-8722-4-20.
   PubMedGoogle Scholar
• Kennedy, D. O. 2016. B vitamins and the brain: Mechanisms, dose and efficacy–a review. Nutrients 8 (2):68. doi: 10.3390/nu8020068.
   PubMed Web of Science ®Google Scholar
• Khan, M. I., S. Rath, V. M. Adhami, and H. Mukhtar. 2018. Targeting epigenome with dietary nutrients in cancer: Current advances and future challenges. Pharmacological Research 129:375–87. doi: 10.1016/j.phrs.2017.12.008.
   PubMed Web of Science ®Google Scholar
• Khan, S., D. Wall, C. Curran, J. Newell, M. J. Kerin, and R. M. Dwyer. 2015. MicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid. BMC Cancer 15 (1):345. doi: 10.1186/s12885-015-1374-y.
   PubMedGoogle Scholar
• Kirkland, J. B. 2009. Niacin status impacts chromatin structure. The Journal of Nutrition 139 (12):2397–401. doi: 10.3945/jn.109.111757.
   PubMed Web of Science ®Google Scholar
• Kok, D. E., R. A. Dhonukshe-Rutten, C. Lute, S. G. Heil, A. G. Uitterlinden, N. van der Velde, J. B. van Meurs, N. M. van Schoor, G. J. Hooiveld, L. C. de Groot, et al. 2015. The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects. Clinical Epigenetics 7 (1):121. doi: 10.1186/s13148-015-0154-5.
   PubMed Web of Science ®Google Scholar
• Kolhe, R., A. K. Mondal, C. Pundkar, S. Periyasamy-Thandavan, B. Mendhe, M. Hunter, C. M. Isales, W. D. Hill, M. W. Hamrick, and S. Fulzele. 2018. Modulation of miRNAs by vitamin C in human bone marrow stromal cells. Nutrients 10 (2):186. doi: 10.3390/nu10020186.
   Web of Science ®Google Scholar
• Kostecki, L. M., M. Thomas, G. Linford, M. Lizotte, L. Toxopeus, A. P. Bartleman, and J. B. Kirkland. 2007. Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 625 (1-2):50–61. doi: 10.1016/j.mrfmmm.2007.05.008.
   PubMed Web of Science ®Google Scholar
• Kothapalli, N., G. Camporeale, A. Kueh, Y. C. Chew, A. M. Oommen, J. B. Griffin, and J. Zempleni. 2005. Biological functions of biotinylated histones. The Journal of Nutritional Biochemistry 16 (7):446–8. doi: 10.1016/j.jnutbio.2005.03.025.
   PubMed Web of Science ®Google Scholar
• Kouzarides, T. 2007. Chromatin modifications and their function. Cell 128 (4):693–705. doi: 10.1016/j.cell.2007.02.005.
   PubMed Web of Science ®Google Scholar
• Lee Chong, T., E. L. Ahearn, and L. Cimmino. 2019. Reprogramming the epigenome with vitamin C. Frontiers in Cell and Developmental Biology 7 (7):128. doi: 10.3389/fcell.2019.00128. eCollection 2019.
   PubMedGoogle Scholar
• Lin, J. R., H. H. Qin, W. Y. Wu, S. J. He, and J. H. Xu. 2014. Vitamin C protects against UV irradiation-induced apoptosis through reactivating silenced tumor suppressor genes p21 and p16 in a Tet-dependent DNA demethylation manner in human skin cancer cells. Cancer Biotherapy and Radiopharmaceuticals 29 (6):257–64. doi: 10.1089/cbr.2014.1647.
   PubMed Web of Science ®Google Scholar
• Liu, B., C. Liu, W. Cong, N. Li, N. Zhou, Y. Tang, C. Wei, H. Bai, Y. Zhang, and J. Xiao. 2017. Retinoid acid-induced microRNA-31-5p suppresses myogenic proliferation and differentiation by targeting CamkIIδ. Skeletal Muscle 7 (1):8. doi: 10.1186/s13395-017-0126-x.
   PubMedGoogle Scholar
• Lopes, N., J. Carvalho, C. Duraes, B. Sousa, M. Gomes, J. L. Costa, C. Oliveira, J. Paredes, and F. Schmitt. 2012. 1Alpha,25-dihydroxyvitamin D3 induces de novo E-cadherin expression in triple-negative breast cancer cells by CDH1-promoter demethylation. Anticancer Research 32 (1):249–57.
   PubMed Web of Science ®Google Scholar
• Lopes, N., B. Sousa, D. Martins, M. Gomes, D. Vieira, L. A. Veronese, F. Milanezi, J. Paredes, J. L. Costa, and F. Schmitt. 2010. Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: A study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions. BMC Cancer 10 (1):483. doi: 10.1186/1471-2407-10-483.
   PubMedGoogle Scholar
• Lorsbach, R. B., J. Moore, S. Mathew, S. C. Raimondi, S. T. Mukatira, and J. R. Downing. 2003. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia 17 (3):637–41. doi: 10.1038/sj.leu.2402834.
   PubMed Web of Science ®Google Scholar
• Luger, K. 2003. Structure and dynamic behavior of nucleosomes. Current Opinion in Genetics & Development 13 (2):127–35. doi: 10.1016/S0959-437X(03)00026-1.
   PubMed Web of Science ®Google Scholar
• Manning, J., B. Mitchell, D. A. Appadurai, A. Shakya, L. J. Pierce, H. Wang, V. Nganga, P. C. Swanson, J. M. May, D. Tantin, et al. 2013. Vitamin C promotes maturation of T-cells. Antioxidants & Redox Signaling 19 (17):2054–67. doi: 10.1089/ars.2012.
   PubMed Web of Science ®Google Scholar
• Maruti, S. S., C. Ulrich, E. R. Jupe, and E. White. 2009. MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: A nested case-control study. Breast Cancer Research 11 (6):R91. doi: 10.1186/bcr2462.
   PubMed Web of Science ®Google Scholar
• Montgomery, M., and A. Srinivasan. 2019. Epigenetic gene regulation by dietary compounds in cancer prevention. Advances in Nutrition 10 (6):1012–28. 1 doi: 10.1093/advances/nmz046.
   PubMed Web of Science ®Google Scholar
• Nervi, C., and F. Grignani. 2014. RARs and microRNAs. Sub-Cellular Biochemistry 70:151–79. doi: 10.1007/978-94-017-9050-5_8.
   PubMedGoogle Scholar
• Orellana, E. A., S. Tenneti, L. Rangasamy, L. T. Lyle, P. S. Low, and A. L. Kasinski. 2017. FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer. Science Translational Medicine 9 (401):eaam9327. doi: 10.1126/scitranslmed.aam9327.
   PubMed Web of Science ®Google Scholar
• Padayatty, S. J., and M. Levine. 2016. Vitamin C: The known and the unknown and Goldilocks. Oral Diseases 22 (6):463–93. doi: 10.1111/odi.12446.
   PubMed Web of Science ®Google Scholar
• Pangrekar, J., K. Krishnaswamy, and V. Jagadeesan. 1993. Effects of riboflavin deficiency and riboflavin administration on carcinogen-DNA binding. Food and Chemical Toxicology 31 (10):745–50. doi: 10.1016/0278-6915(93)90146-P.
   PubMed Web of Science ®Google Scholar
• Parasramka, M. A., E. Ho, D. E. Williams, and R. H. Dashwood. 2012. MicroRNAs, diet, and cancer: New mechanistic insights on the epigenetic actions of phytochemicals. Molecular Carcinogenesis 51 (3):213–30. doi: 10.1002/mc.20822.
   PubMed Web of Science ®Google Scholar
• Park, L. K., S. Friso, and S. W. Choi. 2012. Nutritional influences on epigenetics and age-related disease. Proceedings of the Nutrition Society 71 (1):75–83. doi: 10.1017/S0029665111003302.
   PubMed Web of Science ®Google Scholar
• Pera, M. F. 2013. Epigenetics, vitamin supplements and cellular reprogramming. Nature Genetics 45 (12):1412–141. doi: 10.1038/ng.2834.
   PubMed Web of Science ®Google Scholar
• Pereira, F., A. Barbachano, J. Silva, F. Bonilla, M. J. Campbell, A. Muñoz, and M. J. Larriba. 2011. KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells. Human Molecular Genetics 20 (23):4655–65. doi: 10.1093/hmg/ddr399.
   PubMed Web of Science ®Google Scholar
• Pereira, F., A. Barbachano, P. K. Singh, M. J. Campbell, A. Muñoz, and M. J. Larriba. 2012. Vitamin D has wide regulatory effects on histone demethylase genes. Cell Cycle 11 (6):1081–9. doi: 10.4161/cc.11.6.19508.
   PubMed Web of Science ®Google Scholar
• Piyathilake, C. J., G. L. Johanning, M. Macaluso, M. Whiteside, D. K. Oelschlager, D. C. Heimburger, and W. E. Grizzle. 2000. Localized folate and vitamin B-12 deficiency in squamous cell lung cancer is associated with global DNA hypomethylation. Nutrition and Cancer 37 (1):99–107. doi: 10.1207/S15327914NC3701_13.
   PubMed Web of Science ®Google Scholar
• Sajadian, S. O., C. Tripura, F. S. Samani, M. Ruoss, S. Dooley, H. Baharvand, and A. K. Nussler. 2016. Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7. Clinical Epigenetics 8 (1):46. doi: 10.1186/s13148-016-0213-6.
   PubMed Web of Science ®Google Scholar
• Selhub, J. 2002. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. The Journal of Nutrition, Health & Aging 6 (1):39–42.
   PubMedGoogle Scholar
• Seuter, S., P. Pehkonen, S. Heikkinen, and C. Carlberg. 2013. Dynamics of 1alpha,25-dihydroxyvitamin D3-dependent chromatin accessibility of early vitamin D receptor target genes. Biochimica et Biophysica Acta (Bba) - Gene Regulatory Mechanisms 1829 (12):1266–75. doi: 10.1016/j.bbagrm.2013.10.003.
   PubMed Web of Science ®Google Scholar
• Sharma, S., and A. Litonjua. 2014. Asthma, allergy, and responses to methyl donor supplements and nutrients. Journal of Allergy and Clinical Immunology 133 (5):1246–54. doi: 10.1016/j.jaci.2013.10.039.
   PubMed Web of Science ®Google Scholar
• Shenoy, N., T. Bhagat, E. Nieves, M. Stenson, J. Lawson, G. S. Choudhary, T. Habermann, G. Nowakowski, R. Singh, X. Wu, et al. 2017. Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells. Blood Cancer Journal J7 (7):e587. doi: 10.1038/bcj.2017.65.
   Google Scholar
• Shi, Y. 2007. Histone lysine demethylases: Emerging roles in development, physiology and disease. Nature Reviews Genetics 8 (11):829–33. doi: 10.1038/nrg2218.
   PubMed Web of Science ®Google Scholar
• Spronck, J. C., J. L. Nickerson, and J. B. Kirkland. 2007. Niacin deficiency alters p53 expression and impairs etoposide-induced cell cycle arrest and apoptosis in rat bone marrow cells. Nutrition and Cancer 57 (1):88–99. doi: 10.1080/01635580701268337.
   PubMed Web of Science ®Google Scholar
• Stefanska, B., H. Karlic, F. Varga, K. Fabianowska-Majewska, and A. Haslberger. 2012. Epigenetic mechanisms in anti-cancer actions of bioactive food components–the implications in cancer prevention. British Journal of Pharmacology 167 (2):279–97. doi: 10.1111/j.1476-5381.2012.02002.x.
   PubMed Web of Science ®Google Scholar
• Sun, M., Q. Zhang, X. Yang, S. Y. Qian, and B. Guo. 2016. Vitamin D enhances the efficacy of Irinotecan through miR-627-mediated inhibition of intratumoral drug metabolism. Molecular Cancer Therapeutics 15 (9):2086–95. doi: 10.1158/1535-7163.MCT-16-0095.
   PubMed Web of Science ®Google Scholar
• Tahiliani, M., K. P. Koh, Y. Shen, W. A. Pastor, H. Bandukwala, Y. Brudno, S. Agarwal, L. M. Iyer, D. R. Liu, L. Aravind, et al. 2009. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324 (5929):930–5. doi: 10.1126/science.1170116.
   PubMed Web of Science ®Google Scholar
• Tang, X. H., and L. J. Gudas. 2011. Retinoids, retinoic acid receptors, and cancer. Annual Review of Pathology: Mechanisms of Disease 6 (1):345–64. doi: 10.1146/annurev-pathol-011110-130303.
   PubMedGoogle Scholar
• Tsukada, Y., J. Fang, H. Erdjument-Bromage, M. E. Warren, C. H. Borchers, P. Tempst, and Y. Zhang. 2006. Histone demethylation by a family of JmjC domain-containing proteins. Nature 439 (7078):811–6. doi: 10.1038/nature04433.
   PubMed Web of Science ®Google Scholar
• Uekawa, A., K. Katsushima, A. Ogata, T. Kawata, N. Maeda, K. Kobayashi, A. Maekawa, T. Tadokoro, and Y. Yamamoto. 2009. Change of epigenetic control of cystathionine beta-synthase gene expression through dietary vitamin B12 is not recovered by methionine supplementation. Journal of Nutrigenetics and Nutrigenomics 2 (1):29–36. doi: 10.1159/000165374.
   PubMedGoogle Scholar
• Urvalek, A., K. B. Laursen, and L. J. Gudas. 2014. The roles of retinoic acid and retinoic acid receptors in inducing epigenetic changes. Sub-Cellular Biochemistry 70:129–49. doi: 10.1007/978-94-017-9050-5_7.
   PubMedGoogle Scholar
• Wang, T., K. Chen, X. Zeng, J. Yang, Y. Wu, X. Shi, B. Qin, L. Zeng, M. A. Esteban, G. Pan, et al. 2011. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell 9 (6):575–87. doi: 10.1016/j.stem.2011.10.005.
   PubMed Web of Science ®Google Scholar
• Waterland, R. A. 2006. Assessing the effects of high methionine intake on DNA methylation. The Journal of Nutrition 136 (6):1706S–10S. doi: 10.1093/jn/136.6.1706S.
   PubMed Web of Science ®Google Scholar
• Wu, H., J. Zhao, B. Fu, S. Yin, C. Song, J. Zhang, S. Zhao, and Y. Zhang. 2017. Retinoic acid-induced upregulation of miR-219 promotes the differentiation of embryonic stem cells into neural cells. Cell Death & Disease 8 (7):e2953–e2953. doi: 10.1038/cddis.2017.336.
   PubMedGoogle Scholar
• Yadav, D. K., S. Shrestha, K. A. Lillycrop, C. V. Joglekar, H. Pan, J. D. Holbrook, C. H. Fall, C. S. Yajnik, and G. R. Chandak. 2018. Vitamin B12 supplementation influences methylation of genes associated with Type 2 diabetes and its intermediate traits. Epigenomics 10 (1):71–90. doi: 10.2217/epi-2017-0102.
   PubMed Web of Science ®Google Scholar
• Yiu, T. T., and W. Li. 2015. Pediatric cancer epigenome and the influence of folate. Epigenomics 7 (6):961–73. doi: 10.2217/epi.15.42.
   PubMed Web of Science ®Google Scholar
• Young, J. I., S. Zuchner, and G. Wang. 2015. Regulation of the epigenome by vitamin C. Annual Review of Nutrition 35 (1):545–64. doi: 10.1146/annurev-nutr-071714-034228.
   PubMedGoogle Scholar
• Yu, X. X., Y. H. Liu, X. M. Liu, P. C. Wang, S. Liu, J. K. Miao, Z. Q. Du, and C. X. Yang. 2018. Ascorbic acid induces global epigenetic reprogramming to promote meiotic maturation and developmental competence of porcine oocytes. Scientific Reports 8 (1):6132. doi: 10.1038/s41598-018-24395-y.
   PubMedGoogle Scholar
• Zempleni, J. 2005. Uptake, localization, and noncarboxylase roles of biotin. Annual Review of Nutrition 25 (1):175–96. doi: 10.1146/annurev.nutr.25.121304.131724.
   PubMedGoogle Scholar
• Zempleni, J., Y. C. Chew, Y. I. Hassan, and S. S. Wijeratne. 2008. Epigenetic regulation of chromatin structure and gene function by biotin: Are biotin requirements being met?. Nutrition Reviews 66 (Suppl 1):S46–S48. doi: 10.1111/j.1753-4887.2008.00073.x.
   PubMedGoogle Scholar
• Zhang, J., Y. Gao, M. Yu, H. Wu, Z. Ai, Y. Wu, H. Liu, J. Du, Z. Guo, and Y. Zhang. 2015. Retinoic acid induces embryonic stem cell differentiation by altering both encoding RNA and microRNA expression. PLoS One 10 (7):e0132566. doi: 10.1371/journal.pone.0132566s.
   PubMed Web of Science ®Google Scholar