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Health-promoting role of dietary bioactive compounds through epigenetic modulations: a novel prophylactic and therapeutic approach

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References

  • Achour, M., M. Mousli, M. Alhosin, A. Ibrahim, J. Peluso, C. D. Muller, V. B. Schini-Kerth, A. Hamiche, S. Dhe-Paganon, and C. Bronner. 2013. Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1. Biochemical and Biophysical Research Communications 430 (1):208–12. doi: 10.1016/j.bbrc.2012.06.130.
  • Alagl, A. S., and S. G. Bhat. 2015. Ascorbic acid: New role of an age-old micronutrient in the management of periodontal disease in older adults. Geriatrics & Gerontology International 15 (3):241–54. doi: 10.1111/ggi.12408.
  • Alehagen, U., P. Johansson, J. Aaseth, J. Alexander, and D. Wågsäter. 2017. Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. PLoS One 12 (4):e0174880. doi: 10.1371/journal.pone.0174880.
  • Alenghat, T., and D. Artis. 2014. Epigenomic regulation of host-microbiota interactions. Trends Immunol 35 (11):518–25. doi: 10.1016/j.it.2014.09.007.
  • Alsaweed, M., C. T. Lai, P. E. Hartmann, D. T. Geddes, and F. Kakulas. 2016. Human milk miRNAs primarily originate from the mammary gland resulting in unique miRNA profiles of fractionated milk. Scientific Reports 6 (1):1–13. doi: 10.1038/srep20680.
  • Alvarez, M. C., V. Maso, C. O. Torello, K. P. Ferro, and S. T. O. Saad. 2018. The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes. Clinical Epigenetics 10 (1):139. doi: 10.1186/s13148-018-0563-3.
  • Al-Yousef, N., Z. Shinwari, B. Al-Shahrani, M. Al-Showimi, and N. Al-Moghrabi. 2020. Curcumin induces re-expression of BRCA1 and suppression of γ synuclein by modulating DNA promoter methylation in breast cancer cell lines . Oncology Reports 43 (3):827–38. doi: 10.3892/or.2020.7473.
  • Anderson, O. S., K. E. Sant, and D. C. Dolinoy. 2012. Nutrition and epigenetics: An interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. The Journal of Nutritional Biochemistry 23 (8):853–9. doi: 10.1016/j.jnutbio.2012.03.003.
  • Andrade-Oliveira, V., M. T. Amano, M. Correa-Costa, A. Castoldi, R. J. F. Felizardo, D. C. de Almeida, E. J. Bassi, P. M. Moraes-Vieira, M. I. Hiyane, A. C. D. Rodas, et al. 2015. Gut bacteria products prevent AKI induced by ischemia-reperfusion. Journal of the American Society of Nephrology: JASN 26 (8):1877–88. doi: 10.1681/asn.2014030288.
  • Appari, M., K. R. Babu, A. Kaczorowski, W. Gross, and I. Herr. 2014. Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition. International Journal of Oncology 45 (4):1391–400. doi: 10.3892/ijo.2014.2539.
  • Arpaia, N., C. Campbell, X. Fan, S. Dikiy, J. van der Veeken, P. Deroos, H. Liu, J. R. Cross, K. Pfeffer, P. J. Coffer, et al. 2013. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504 (7480):451–5. doi: 10.1038/nature12726.
  • Ashoori, M., and A. Saedisomeolia. 2014. Riboflavin (vitamin B2) and oxidative stress: a review. The British Journal of Nutrition 111 (11):1985–91. doi: 10.1017/s0007114514000178.
  • Azimi, A., M. F. Hagh, M. Talebi, B. Yousefi, A. A. H. p Feizi, B. Baradaran, A. A. Movassaghpour, K. Shamsasenjan, T. Khanzedeh, A. H. Ghaderi, et al. 2015. Time– and concentration-dependent effects of resveratrol on miR-15a and miR16-1Expression and apoptosis in the CCRF-CEM acute lymphoblastic leukemia cell line. Asian Pacific Journal of Cancer Prevention 16 (15):6463–8., doi: 10.7314/APJCP.2015.16.15.6463.
  • Bannister, A. J., and T. Kouzarides. 2011. Regulation of chromatin by histone modifications. Cell Research 21 (3):381–95. doi: 10.1038/cr.2011.22.
  • Basso, E., G. Regazzo, M. Fiore, V. Palma, G. Traversi, A. Testa, F. Degrassi, and R. Cozzi. 2016. Resveratrol affects DNA damage induced by ionizing radiation in human lymphocytes in vitro. Mutation Research. Genetic Toxicology and Environmental Mutagenesis 806:40–6. doi: 10.1016/j.mrgentox.2016.07.005.
  • Beaver, L. M., R. Kuintzle, A. Buchanan, M. W. Wiley, S. T. Glasser, C. P. Wong, G. S. Johnson, J. H. Chang, C. V. Löhr, D. E. Williams, et al. 2017. Long noncoding RNAs and sulforaphane: A target for chemoprevention and suppression of prostate cancer. The Journal of Nutritional Biochemistry 42:72–83. doi: 10.1016/j.jnutbio.2017.01.001.
  • Berridge, M. J. 2017. Vitamin D deficiency and diabetes. The Biochemical Journal 474 (8):1321–32. doi: 10.1042/BCJ20170042.
  • Bhat, M. I., and R. Kapila. 2017. Dietary metabolites derived from gut microbiota: Critical modulators of epigenetic changes in mammals. Nutrition Reviews 75 (5):374–89. doi: 10.1093/nutrit/nux001.
  • Bhat, M. I., A. Kumari, S. Kapila, and R. Kapila. 2019. Probiotic lactobacilli mediated changes in global epigenetic signatures of human intestinal epithelial cells during Escherichia coli challenge. Annals of Microbiology 69 (6):603–12. doi: 10.1007/s13213-019-01451-0.
  • Bhullar, K. S., and B. P. Hubbard. 2015. Lifespan and healthspan extension by resveratrol. Biochimica et Biophysica Acta 1852 (6):1209–18. doi: 10.1016/j.bbadis.2015.01.012.
  • Bo, S., G. Togliatto, R. Gambino, V. Ponzo, G. Lombardo, R. Rosato, M. Cassader, and M. F. Brizzi. 2018. Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: A double-blind randomized controlled trial with resveratrol supplementation. Acta Diabetologica 55 (4):331–40. doi: 10.1007/s00592-017-1097-4.
  • Bourassa, M. W., I. Alim, S. J. Bultman, and R. R. Ratan. 2016. Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health? Neuroscience Letters 625:56–63. doi: 10.1016/j.neulet.2016.02.009.
  • Boyanapalli, S. S., W. Li, F. Fuentes, Y. Guo, C. N. Ramirez, X. P. Gonzalez, D. Pung, and A. N. Kong. 2016. Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells. Pharmacological Research 114:175–84. doi: 10.1016/j.phrs.2016.10.021.
  • Brockers, K., and R. Schneider. 2019. Histone H1, the forgotten histone. Epigenomics 11 (4):363–6. doi: 10.2217/epi-2019-0018.
  • Buhrmann, C., P. Shayan, B. Popper, A. Goel, and M. Shakibaei. 2016. SIRT1 is required for resveratrol-mediated chemopreventive effects in colorectal cancer cells. Nutrients 8 (3):145. doi: 10.3390/nu8030145.
  • Bunker, S. K., A. Dutta, J. Pradhan, J. Dandapat, and G. B. N. Chainy. 2019. Curcumin restores hepatic epigenetic changes in propylthiouracil(PTU)Induced hypothyroid male rats: A study on DNMTs, MBDs, GADD45a, C/EBP-β and PCNA . Food Chem. Toxicol 123:169–80. doi: 10.1016/j.fct.2018.10.050.
  • Busbee, P. B., M. Nagarkatti, and P. S. Nagarkatti. 2014. Natural indoles, indole-3-carbinol and 3,3'-diindolymethane, inhibit T cell activation by staphylococcal enterotoxin B through epigenetic regulation involving HDAC expression. Toxicol. Appl. Pharmacol 274 (1):7–16. doi: 10.1016/j.taap.2013.10.022.
  • Busbee, P. B., M. Nagarkatti, and P. S. Nagarkatti. 2015. Natural Indoles, Indole-3-Carbinol (I3C) and 3,3'-diindolylmethane (DIM), attenuate staphylococcal enterotoxin B-mediated liver injury by downregulating miR-31 expression and promoting caspase-2-mediated apoptosis. Plos ONE 10 (2):e0118506. doi: 10.1371/journal.pone.0118506.
  • Caliceti, C., P. Franco, S. Spinozzi, A. Roda, and A. F. G. Cicero. 2016. Berberine: New insights from pharmacological aspects to clinical evidences in the management of metabolic disorders. Current Medicinal Chemistry 23 (14):1460–76. doi: 10.2174/0929867323666160411143314.
  • Camarena, V., and G. Wang. 2016. The epigenetic role of vitamin C in health and disease. Cellular and Molecular Life Sciences: CMLS 73 (8):1645–58. doi: 10.1007/s00018-016-2145-x.
  • Canani, R. B., M. Di Costanzo, and L. Leone. 2012. The epigenetic effects of butyrate: Potential therapeutic implications for clinical practice. Clinical Epigenetics 4 (1):4. doi: 10.1186/1868-7083-4-4.
  • Carlos-Reyes, Á., J. S. López-González, M. Meneses-Flores, D. Gallardo-Rincón, E. Ruíz-García, L. A. Marchat, H. Astudillo-de la Vega, O. N. Hernández de la Cruz, and C. López-Camarillo. 2019. Dietary compounds as epigenetic modulating agents in cancer. Front Genet 10:79. doi: 10.3389/fgene.2019.00079.
  • Chang, P. V., L. Hao, S. Offermanns, and R. Medzhitov. 2014. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proceedings of the National Academy of Sciences of the United States of America 111 (6):2247–52. doi: 10.1073/pnas.1322269111.
  • Chang, S., L. Wang, Y. Guan, S. Shangguan, Q. Du, Y. Wang, T. Zhang, and Y. Zhang. 2013. Long interspersed nucleotide element-1 hypomethylation in folate-deficient mouse embryonic stem cells. Journal of Cellular Biochemistry 114 (7):1549–58. doi: 10.1002/jcb.24496.
  • Chang, X., H. Yan, J. Fei, M. Jiang, H. Zhu, D. Lu, and X. Gao. 2010. Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats. Journal of Lipid Research 51 (9):2504–15. doi: 10.1194/jlr.M001958.
  • Chen, H., C. Lu, H. Liu, M. Wang, H. Zhao, Y. Yan, and L. Han. 2017. Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway. International Immunopharmacology 48:110–7. doi: 10.1016/j.intimp.2017.04.022.
  • Chen, Y.-Y., L. Zhang, D.-L. Shi, X.-H. Song, Y.-L. Shen, M.-Z. Zheng, and L.-L. Wang. 2017. Resveratrol attenuates subacute systemic inflammation-induced spatial memory impairment via inhibition of astrocyte activation and enhancement of synaptophysin expression in the hippocampus. Annals of Clinical and Laboratory Science 47 (1):17–24.
  • Cicero, A. F., F. Fogacci, and A. Colletti. 2017. Potential role of bioactive peptides in prevention and treatment of chronic diseases: A narrative review. British Journal of Pharmacology 174 (11):1378–94. doi: 10.1111/bph.13608.
  • Coupland, K. G., G. D. Mellick, P. A. Silburn, K. Mather, N. J. Armstrong, P. S. Sachdev, H. Brodaty, Y. Huang, G. M. Halliday, M. Hallupp, et al. 2014. DNA methylation of the MAPT gene in Parkinson's disease cohorts and modulation by vitamin E In Vitro. Movement Disorders 29 (13):1606–14. doi: 10.1002/mds.25784.
  • Dan, J., and T. Chen. 2016. Genetic studies on mammalian DNA methyltransferases. Advances in Experimental Medicine and Biology 945:123–50. doi: 10.1007/978-3-319-43624-1_6.
  • Das, S., K. Bryan, P. G. Buckley, O. Piskareva, I. M. Bray, N. Foley, J. Ryan, J. Lynch, L. Creevey, J. Fay, et al. 2013. Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs. Oncogene 32 (24):2927–36. doi: 10.1038/onc.2012.311.
  • David, A. V. A., R. Arulmoli, and S. Parasuraman. 2016. Overviews of biological importance of quercetin: A bioactive flavonoid. Pharmacognosy Reviews 10 (20):84–9. doi: 10.4103/0973-7847.194044.
  • Davis-Yadley, A. H., and M. P. Malafa. 2015. Vitamins in pancreatic cancer: A review of underlying mechanisms and future applications. Advances in Nutrition (Bethesda, Md.) 6 (6):774–802. doi: 10.3945/an.115.009456.
  • De la Parra, C., L. Castillo-Pichardo, A. Cruz-Collazo, L. Cubano, R. Redis, G. A. Calin, and S. Dharmawardhane. 2016. Soy isoflavone genistein-mediated downregulation of miR-155 contributes to the anticancer effects of genistein. Nutrition and Cancer 68 (1):154–64. doi: 10.1080/01635581.2016.1115104.
  • Deans, C., and K. A. Maggert. 2015. What do you mean, “epigenetic”? Genetics 199 (4):887–96. doi: 10.1534/genetics.114.173492.
  • Deb, G., V. S. Thakur, A. M. Limaye, and S. Gupta. 2015. Epigenetic induction of tissue inhibitor of matrix metalloproteinase-3 by green tea polyphenols in breast cancer cells. Molecular Carcinogenesis 54 (6):485–99. doi: 10.1002/mc.22121.
  • Dong, W., F. Li, Z. Pan, S. Liu, H. Yu, X. Wang, S. Bi, and W. Zhang. 2013. Resveratrol ameliorates subacute intestinal ischemia-reperfusion injury. The Journal of Surgical Research 185 (1):182–9. doi: 10.1016/j.jss.2013.05.013.
  • Dong, J. J., J. H. Ye, J. L. Lu, X. Q. Zheng, and Y. R. Liang. 2011. Isolation of antioxidant catechins from green tea and its decaffeination. Food and Bioproducts Processing 89 (1):62–6. doi: 10.1016/j.fbp.2010.02.003.
  • Donohoe, D. R., D. Holley, L. B. Collins, S. A. Montgomery, A. C. Whitmore, A. Hillhouse, K. P. Curry, S. W. Renner, A. Greenwalt, E. P. Ryan, et al. 2014. A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner. Cancer Discovery 4 (12):1387–97. doi: 10.1158/2159-8290.cd-14-0501.
  • Du, Y. P., J. S. Peng, A. Sun, Z. H. Tang, W. H. Ling, and H. L. Zhu. 2009. Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model. BMC Cancer 9 (1):261. doi: 10.1186/1471-2407-9-261.
  • Dufour, V., M. Stahl, and C. Baysse. 2015. The antibacterial properties of isothiocyanates. Microbiology (Reading, England) 161 (Pt 2):229–43. doi: 10.1099/mic.0.082362-0.
  • Elliott, D. M., M. Nagarkatti, and P. S. Nagarkatti. 2016. 3,39-diindolylmethane ameliorates staphylococcal enterotoxin B–induced acute lung injury through alterations in the expression of MicroRNA that target apoptosis and cell-cycle arrest in activated T cells. The Journal of Pharmacology and Experimental Therapeutics 357 (1):177–87. doi: 10.1038/onc.2012.311.
  • Esmaeili, M. A. 2016. Combination of siRNA-directed gene silencing with epigallocatechin-3-gallate (EGCG) reverses drug resistance in human breast cancer cells. Journal of Chemical Biology 9 (1):41–52. doi: 10.1007/s12154-015-0144-2.
  • Felizardo, R. J., D. C. de Almeida, R. L. Pereira, I. K. Watanabe, N. T. Doimo, W. R. Ribeiro, M. A. Cenedeze, M. I. Hiyane, M. T. Amano, T. T. Braga, et al. 2019. Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 33 (11):11894–908. doi: 10.1096/fj.201901080r.
  • Feng, M., X. Luo, C. Gu, Y. Li, X. Zhu, and J. Fei. 2015. Systematic analysis of berberine-induced signaling pathway between miRNA clusters and mRNAs and identification of miR-99a ∼ 125b cluster function by seed-targeting inhibitors in multiple myeloma cells. RNA Biology 12 (1):82–91. doi: 10.1080/15476286.2015.1017219.
  • Fischer, A., O. Simone, C. Schmelzer, and F. Döring. 2012. Ubiquinol decreases monocytic expression and DNA methylation of the pro-inflammatory chemokine ligand 2 gene in humans. BMC Research Notes 5:540. doi: 10.1186/1756-0500-5-540.
  • Forster, T., V. Rausch, Y. Zhang, O. Isayev, K. Heilmann, F. Schoensiegel, L. Liu, M. Nessling, K. Richter, S. Labsch, et al. 2014. Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication. Oncotarget 5 (6):1621–34. doi: 10.18632/oncotarget.1764.
  • Furusawa, Y., Y. Obata, S. Fukuda, T. A. Endo, G. Nakato, D. Takahashi, Y. Nakanishi, C. Uetake, K. Kato, T. Kato, et al. 2013. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504 (7480):446–50. doi: 10.1038/nature12721.
  • Gan, M., T. Zheng, L. Shen, Y. Tan, Y. Fan, S. Shuai, L. Bai, X. Li, J. Wang, S. Zhang, et al. 2019. Genistein reverses isoproterenol-induced cardiac hypertrophy by regulating miR-451/TIMP2. Biomedicine and Pharmacotherapy 112:108618. doi: 10.1016/j.biopha.2019.108618.
  • Gao, Y., and T. O. Tollefsbol. 2018. Combinational proanthocyanidins and resveratrol synergistically inhibit human breast cancer cells and impact epigenetic–mediating machinery. International Journal of Molecular Sciences 19 (8):2204. doi: 10.3390/ijms19082204.
  • Gerecke, C., F. Schumacher, A. Edlich, A. Wetzel, G. Yealland, L. K. Neubert, B. Scholtka, T. Homann, and B. Kleuser. 2018. Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells. Oncotarget 9 (67):32822–40. doi: 10.18632/oncotarget.25999.
  • Gerhauser, C. 2013. Epigenetic impact of dietary isothiocyanates in cancer chemoprevention. Current Opinion in Clinical Nutrition and Metabolic Care 16 (4):405–10. doi: 10.1097/mco.0b013e328362014e.
  • Gezici, S., and N. Sekeroglu. 2017. Regulation of MicroRNAs by natural products and bioactive compounds obtained from common medicinal plants: Novel strategy in cancer therapy. Cancer 1:4. doi:10.5530/ijper.51.3s.71.
  • Ghadimi, D., U. Helwig, J. Schrezenmeir, K. J. Heller, and M. de Vrese. 2012. Epigenetic imprinting by commensal probiotics inhibits the IL-23/IL-17 axis in an in vitro model of the intestinal mucosal immune system. Journal of Leukocyte Biology 92 (4):895–911. doi: 10.1189/jlb.0611286.
  • Gil‐Chávez, J. G., Villa, J. A. F. J. Ayala‐Zavala, B. J. Heredia, D. Sepulveda, E. M. Yahia, and G. A. González‐Aguilar. 2013. Technologies for extraction and production of bioactive compounds to be used as nutraceuticals and food ingredients: An overview. Comprehensive Reviews in Food Science and Food Safety 12 (1):5–23. doi: 10.1111/1541-4337.12005.
  • Gonzalez-Sarrias, A., M. A. Nunez-Sanchez, J. Tome-Carneiro, F. A. Tomas-Barberan, M. T. Garcia-Conesa, and J. C. Espin. 2016. Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key-associated molecular hallmarks: MicroRNA cell specific induction of CDKN1A (p21) as a common mechanism involved. Molecular Nutrition & Food Research 60:701–16. doi: 10.1002/mnfr.201500780.
  • Good, C. R., S. Panjarian, A. D. Kelly, J. Madzo, B. Patel, J. Jelinek, and J. J. Issa. 2018. TET1-mediated hypomethylation activates oncogenic signaling in triple-negative breast cancer. Cancer Research 78 (15):4126–37. doi: 10.1158/0008-5472.can-17-2082.
  • Gu, W., M. Cueto, P. R. Jensen, W. Fenical, and R. B. Silverman. 2007. Microsporins A and B: New histone deacetylase inhibitors from the marine-derived fungus Microsporum cf. gypseum and the solid-phase synthesis of microsporin A. Tetrahedron 63 (28):6535–41. doi: 10.1016/j.tet.2007.04.025.
  • Guo, Y., L. Shu, C. Zhang, Z. Y. Su, and A. N. T. Kong. 2015. Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1. Biochemical Pharmacology 94 (2):69–78. doi: 10.1016/j.bcp.2015.01.009.
  • Guo, Y., R. Wu, J. M. Gaspar, D. Sargsyan, Z. Y. Su, C. Zhang, L. Gao, D. Cheng, W. Li, C. Wang, et al. 2018. DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice. Carcinogenesis 39 (5):669–80. doi: 10.1093/carcin/bgy043.
  • Gupta, R., L. K. Bhatt, and M. Momin. 2019. Potent antitumor activity of Laccaic acid and Phenethyl isothiocyanate combination in colorectal cancer via dual inhibition of DNA methyltransferase-1 and Histone deacetylase-1. Toxicology and Applied Pharmacology 377:114631. doi: 10.1016/j.taap.2019.114631.
  • Gustafson, C. B., C. Yang, K. M. Dickson, H. Shao, V. D. Booven, J. W. Harbour, Z. J. Liu, and G. Wang. 2015. Epigenetic reprogramming of melanoma cells by vitamin C treatment. Clinical Epigenetics 7 (1):51. doi: 10.1186/s13148-015-0087-z.
  • Gutierrez-Mariscal, F. M., E. M. Yubero-Serrano, J. M. Villalba, and J. Lopez-Miranda. 2019. Coenzyme Q10: From bench to clinic in aging diseases, a translational review. Critical Reviews in Food Science and Nutrition 59 (14):2240–18. doi: 10.1080/10408398.2018.1442316.
  • Han, R., Q. Sun, J. Wu, P. Zheng, and G. Zhao. 2016. Sodium butyrate upregulates miR-203 expression to exert anti-proliferation effect on colorectal cancer cells. Cellular Physiology and Biochemistry 39 (5):1919–29. doi: 10.1159/000447889.
  • Hanieh, H. 2015. Aryl hydrocarbon receptor-microRNA-212/132 axis in human breast cancer suppresses metastasis by targeting SOX4. Molecular Cancer 14 (1):172. doi: 10.1186/s12943-015-0443-9.
  • Haq, M. R. U., R. Kapila, R. Sharma, V. Saliganti, and S. Kapila. 2014. Comparative evaluation of cow β-casein variants (A1/A2) consumption on Th 2-mediated inflammatory response in mouse gut. European Journal of Nutrition 53 (4):1039–49. doi: 10.1007/s00394-013-0606-7.
  • Hargraves, K. G., L. He, and G. L. Firestone. 2016. Phytochemical regulation of the tumor suppressive microRNA, miR-34a, by p53-dependent and independent responses in human breast cancer cells. Molecular Carcinogenesis 55 (5):486–98. doi: 10.1186/s12943-015-0443-9.
  • Harrison, S. J., M. Bishton, S. E. Bates, S. Grant, R. L. Piekarz, R. W. Johnstone, Y. Dai, B. Lee, M. E. Araujo, and H. M. Prince. 2012. A focus on the preclinical development and clinical status of the histone deacetylase inhibitor, romidepsin (depsipeptide, Istodax(®). Epigenomics 4 (5):571–89. doi: 10.2217/epi.12.52.
  • Hassan, M. K., H. Watari, A. E. Salah-Eldin, A. S. Sultan, Z. Mohamed, Y. Fujioka, Y. Ohba, and N. Sakuragi. 2014. Histone deacetylase inhibitors sensitize lung cancer cells to hyperthermia: Involvement of Ku70/SirT-1 in thermo-protection. PLoS One 9 (4):e94213. doi: 10.1371/journal.pone.0094213.
  • Hatfield, I., I. Harvey, E. R. Yates, J. R. Redd, L. T. Reiter, and D. Bridges. 2015. The role of TORC1 in muscle development in Drosophila. Scientific Reports 5 (1):9676. doi: 10.1038/srep09676.
  • Heger, V., J. Tyni, A. Hunyadi, L. Horáková, M. Lahtela-Kakkonen, and M. Rahnasto-Rilla. 2019. Quercetin based derivatives as sirtuin inhibitors. Biomedicine and Pharmacotherapy 111:1326–33. doi: 10.1016/j.biopha.2019.01.035.
  • Heo, S. H., J. Kwak, and K. L. Jang. 2015. All-trans retinoic acid induces p53-depenent apoptosis in human hepatocytes by activating p14 expression via promoter hypomethylation . Cancer Letters 362 (1):139–48. doi: 10.1016/j.canlet.2015.03.036.
  • Hernández-Camacho, J. D., M. Bernier, G. López-Lluch, and P. Navas. 2018. Coenzyme Q10 Supplementation in aging and disease. Frontiers in Physiology 9:44. doi: 10.3389/fphys.2018.00044.
  • Hirata, H., Y. Hinoda, V. Shahryari, G. Deng, Y. Tanaka, Z. L. Tabatabai, and R. Dahiya. 2014. Genistein downregulates onco-miR-1260b and upregulates sFRP1 and Smad4 via demethylation and histone modification in prostate cancer cells. British Journal of Cancer 110 (6):1645–54. doi: 10.1038/bjc.2014.48.
  • Houghton, C. A., R. G. Fassett, and J. S. Coombes. 2013. Sulforaphane: Translational research from laboratory bench to clinic. Nutrition Reviews 71 (11):709–26. doi: 10.1111/nure.12060.
  • Hsu, C. H., K. L. Peng, M. L. Kang, Y. R. Chen, Y. C. Yang, C. H. Tsai, C. S. Chu, Y. M. Jeng, Y. T. Chen, F. M. Lin, et al. 2012. TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases. Cell Reports 2 (3):568–79. doi: 10.1016/j.celrep.2012.08.030.
  • Hu, S., L. Liu, E. B. Chang, J. Y. Wang, and J. P. Raufman. 2015. Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells. Molecular Cancer 14 (1):180. doi: 10.1186/s12943-015-0450-x.
  • Huang, Y., R. Wu, Z. Y. Su, Y. Guo, X. Zheng, C. S. Yang, and A. N. Kong. 2017. A naturally occurring mixture of tocotrienols inhibits the growth of human prostate tumor, associated with epigenetic modifications of cyclin-dependent kinase inhibitors p21 and p27. Journal of Nutritional Biochemistry 40:155–63. doi: 10.1016/j.jnutbio.2016.10.019.
  • Hung, C. H., S. H. Chan, P. M. Chu, and K. L. Tsai. 2015. Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation. Molecular Nutrition & Food Research 59 (10):1905–17. doi: 10.1002/mnfr.201500144.
  • Hyun, K., J. Jeon, K. Park, and J. Kim. 2017. Writing, erasing and reading histone lysine methylations. Experimental & Molecular Medicine 49 (4):e324. doi: 10.1038/emm.2017.11.
  • Iciek, M., I. Kwiecień, and L. Włodek. 2009. Biological properties of garlic and garlic-derived organosulfur compounds. Environmental and Molecular Mutagenesis 50 (3):247–65. doi: 10.1002/em.20474.
  • Inoue, H., and R. Nakata. 2015. Resveratrol targets in inflammation. Endocrine, Metabolic & Immune Disorders Drug Targets 15 (3):186–95. doi: 10.2174/1871530315666150316120316.
  • Iqbal, J., B. A. Abbasi, A. T. Khalil, B. Ali, T. Mahmood, S. Kanwal, S. A. Shah, and W. Ali. 2018. Dietary isoflavones, the modulator of breast carcinogenesis: Current landscape and future perspectives. Asian Pacific Journal of Tropical Medicine 11 (3):186–93. doi: 10.4103/1995-7645.228432.
  • Ismail, T., C. Calcabrini, A. R. Diaz, C. Fimognari, E. Turrini, E. Catanzaro, S. Akhtar, and P. Sestili. 2016. Ellagitannins in cancer chemoprevention and therapy. Toxins 8 (5):151. doi: 10.3390/toxins8050151.
  • Izquierdo-Torres, E., A. Hernández-Oliveras, I. Meneses-Morales, G. Rodríguez, G. Fuentes-García, and Á. Zarain-Herzberg. 2019. Resveratrol up-regulates ATP2A3 gene expression in breast cancer cell lines through epigenetic mechanisms. The International Journal of Biochemistry & Cell Biology 113:37–47. doi: 10.1016/j.biocel.2019.05.020.
  • Jafary, H., S. Ahmadian, and M. Soleimani. 2014. The enhanced apoptosis and antiproliferative response to combined treatment with valproate and nicotinamide in MCF-7 breast cancer cells. Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine 35 (3):2701–10. doi: 10.1007/s13277-013-1356-0.
  • Jeong, H. J., J. B. Jeong, D. S. Kim, and B. O. de Lumen. 2007. Inhibition of core histone acetylation by the cancer preventive peptide lunasin. Journal of Agricultural and Food Chemistry 55 (3):632–7. doi: 10.1021/jf062405u.
  • Jiang, P., C. Xu, L. Chen, A. Chen, X. Wu, M. Zhou, I. U. Haq, Z. Mariyam, and Q. Feng. 2018. Epigallocatechin-3-gallate inhibited cancer stem cell-like properties by targeting hsa-mir-485-5p/RXRα in lung cancer. Journal of Cellular Biochemistry 119 (10):8623–35. doi: 10.1002/jcb.27117.
  • Jiang, L. L., S. J. Zhou, X. M. Zhang, H. Q. Chen, and W. Liu. 2016. Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 78:74–80. doi: 10.1016/j.biopha.2015.11.007.
  • Jutooru, I., A. S. Guthrie, G. Chadalapaka, S. Pathi, K. Kim, R. Burghardt, U. H. Jin, and S. Safe. 2014. Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents. Molecular and Cellular Biology 34 (13):2382–95. doi: 10.1128/mcb.01602-13.
  • Kala, R., H. N. Shah, S. L. Martin, and T. O. Tollefsbol. 2015. Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer. BMC Cancer 15 (1):672. doi: 10.1186/s12885-015-1693-z.
  • Kaluski, S., M. Portillo, A. Besnard, D. Stein, M. Einav, L. Zhong, U. Ueberham, T. Arendt, R. Mostoslavsky, A. Sahay, et al. 2017. Neuroprotective functions for the histone deacetylase SIRT6. Cell Reports 18 (13):3052–62. doi: 10.1016/j.celrep.2017.03.008.
  • Kang, I., M. Okla, and S. Chung. 2014. Ellagic acid inhibits adipocyte differentiation through coactivator-associated arginine methyltransferase 1-mediated chromatin modification. The Journal of Nutritional Biochemistry 25 (9):946–53. doi: 10.1016/j.jnutbio.2014.04.008.
  • Karlsson, O., R. S. Rodosthenous, C. Jara, K. J. Brennan, R. O. Wright, A. A. Baccarelli, and R. J. Wright. 2016. Detection of long non-coding RNAs in human breastmilk extracellular vesicles: Implications for early child development. Epigenetics 11 (10):721–9. doi: 10.1080/15592294.2016.1216285.
  • Khan, M. A., A. Hussain, M. K. Sundaram, U. Alalami, D. Gunasekera, L. Ramesh, A. Hamza, and U. Quraishi. 2015. (-)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells. Oncology Reports 33 (4):1976–84. doi: 10.3892/or.2015.3802.
  • Khan, S., D. Wall, C. Curran, J. Newell, M. J. Kerin, and R. M. Dwyer. 2015. MicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid. BMC Cancer 15 (1):345. doi: 10.1186/s12885-015-1374-y.
  • Kikuchi, H., H. Mimuro, and F. Kuribayashi. 2018. Resveratrol strongly enhances the retinoic acid-induced superoxide generating activity via up-regulation of gp91-phox gene expression in U937 cells. Biochemical and Biophysical Research Communications 495 (1):1195–200. doi: 10.1016/j.bbrc.2017.11.161.
  • Kim, S. M., S. M. Lim, J. A. Yoo, M. J. Woo, and K. H. Cho. 2015. Consumption of high-dose vitamin C (1250 mg per day) enhances functional and structural properties of serum lipoprotein to improve anti-oxidant, anti-atherosclerotic, and anti-aging effects via regulation of anti-inflammatory microRNA. Food & Function 6 (11):3604–12. doi: 10.1039/c5fo00738k.
  • Kocic, H., G. Damiani, B. Stamenkovic, M. Tirant, A. Jovic, D. Tiodorovic, and K. Peris. 2019. Dietary compounds as potential modulators of microRNA expression in psoriasis. Therapeutic Advances in Chronic Disease 10:2040622319864805. doi: 10.1177/2040622319864805.
  • Kong, D., E. Heath, W. Chen, M. L. Cher, I. Powell, L. Heilbrun, Y. Li, S. Ali, S. Sethi, O. Hassan, et al. 2012. Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM. PLoS One 7 (3):e33729. doi: 10.1371/journal.pone.0033729.
  • Kowshik, J., H. Giri, T. K. Kishore, R. Kesavan, R. N. Vankudavath, G. B. Reddy, M. Dixit, and S. Nagini. 2014. Ellagic acid inhibits VEGF/VEGFR2, PI3K/Akt and MAPK signaling cascades in the hamster cheek pouch carcinogenesis model. Anti-Cancer Agents in Medicinal Chemistry14 (9):1249–60. doi: 10.2174/1871520614666140723114217.
  • Kremenović, D. 2012. Epigenetic control of TLR4-mediated gene expression induced by bacteria and bacterial cell wall components in human intestinal epithelial cells. Diploma thesis., University of Vienna.
  • Kumar, U., U. Sharma, and G. Rathi. 2017. Reversal of hypermethylation and reactivation of glutathione S-transferase pi 1 gene by curcumin in breast cancer cell line. Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine 39 (2):1010428317692258. doi: 10.1177/1010428317692258.
  • Latruffe, N., A. Lançon, R. Frazzi, V. Aires, D. Delmas, J. J. Michaille, F. Djouadi, J. Bastin, and M. Cherkaoui‐Malki. 2015. Exploring new ways of regulation by resveratrol involving miRNAs, with emphasis on inflammation. Annals of the New York Academy of Sciences 1348 (1):97–106. doi: 10.1111/nyas.12819.
  • Lewinska, A., J. Adamczyk, J. Pajak, S. Stoklosa, B. Kubis, P. Pastuszek, E. Slota, and M. Wnuk. 2014. Curcumin-mediated decrease in the expression of nucleolar organizer regions in cervical cancer (HeLa) cells. Mutation Research - Genetic Toxicology and Environmental Mutagenesis (MRGTEM) 771:43–52. doi: 10.1016/j.mrgentox.2014.07.001.
  • Lewis, K. A., H. R. Jordan, and T. O. Tollefsbol. 2018. Effects of SAHA and EGCG on growth potentiation of triple-negative breast cancer cells. Cancers 11 (1):23. doi: 10.3390/cancers11010023.
  • Libri, V., C. Yandim, S. Athanasopoulos, N. Loyse, T. Natisvili, P. P. Law, P. K. Chan, T. Mohammad, M. Mauri, K. T. Tam, et al. 2014. Epigenetic and neurological effects and safety of highdose nicotinamide in patients with Friedreich's ataxia: An exploratory, open-label, dose-escalation study. The Lancet 384 (9942):504–13. doi: 10.1016/S0140-6736(14)60382-2.
  • Li, Y., F. Chen, A. Wei, F. Bi, X. Zhu, S. Yin, W. Lin, and W. Cao. 2019. Klotho recovery by genistein via promoter histone acetylation and DNA demethylation mitigates renal fibrosis in mice. Journal of Molecular Medicine (Berlin, Germany) 97 (4):541–52. doi: 10.1007/s00109-019-01759-z.
  • Li, W., H. Liu, M. Yu, X. Zhang, M. Zhang, J. X. Wilson, and G. Huang. 2015. Folic acid administration inhibits amyloid β-peptide accumulation in APP/PS1 transgenic mice. The Journal of Nutritional Biochemistry 26 (8):883–91. doi: 10.1016/j.jnutbio.2015.03.009.
  • Lin, C., D. Wei, D. Xin, J. Pan, and M. Huang. 2019. Ellagic acid inhibits proliferation and migration of cardiac fibroblasts by down-regulating expression of HDAC1. Journal of Toxicological Sciences 44 (6):425–33. doi: 10.2131/jts.44.425.
  • Li, Y. Y., D. Tang, Y. L. Du, C. Y. Cao, Y. Q. Nie, J. Cao, and Y. J. Zhou. 2018. Fatty liver mediated by peroxisome proliferator‐activated receptor‐α DNA methylation can be reversed by a methylation inhibitor and curcumin. Journal of Digestive Diseases 19 (7):421–30. doi: 10.1111/1751-2980.12610.
  • Liu, M., H. Ohtani, W. Zhou, A. D. Ørskov, J. Charlet, Y. W. Zhang, H. Shen, S. B. Baylin, G. Liang, K. Grønbaek, et al. 2016. Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine. Proceedings of the National Academy of Sciences of the United States of America 113 (37):10238–44. doi: 10.1073/pnas.1612262113.
  • Liu, C. M., C. Y. Peng, Y. W. Liao, M. Y. Lu, M. L. Tsai, J. C. Yeh, C. H. Yu, and C. C. Yu. 2017. Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction. Journal of the Formosan Medical Association = Taiwan yi Zhi 116 (1):41–8. doi: 10.1016/j.jfma.2016.01.004.
  • Liu, Y., L. A. Salvador, S. Byeon, Y. Ying, J. C. Kwan, B. K. Law, J. Hong, and H. Luesch. 2010. Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. The Journal of Pharmacology and Experimental Therapeutics 335 (2):351–61. doi: 10.1124/jpet.110.172387.
  • Liu, W., Y. Song, C. Zhang, P. Gao, B. Huang, and J. Yang. 2018. The protective role of all-transretinoic acid (ATRA) against colorectal cancer development is achieved via increasing miR-3666 expression and decreasing E2F7 expression. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 104:94–101. doi: 10.1016/j.biopha.2018.05.015.
  • Liu, D., and J. Zempleni. 2014. Transcriptional regulation of the albumin gene depends on the removal of histone methylation marks by the FAD-dependent monoamine oxidase lysine-specific demethylase 1 in HepG2 human hepatocarcinoma cells . The Journal of Nutrition 144 (7):997–1001. doi: 10.3945/jn.114.192187.
  • Li, Y., J. Yao, C. Han, J. Yang, M. T. Chaudhry, S. Wang, H. Liu, and Y. Yin. 2016. Quercetin, inflammation and immunity. Nutrients 8 (3):167. doi: 10.3390/nu8030167.
  • Lloyd-Price, J., G. Abu-Ali, and C. Huttenhower. 2016. The healthy human microbiome. Genome Medicine 8 (1):51. doi: 10.1186/s13073-016-0307-y.
  • Lubecka-Pietruszewska, K., A. Kaufman-Szymczyk, B. Stefanska, B. Cebula-Obrzut, P. Smolewski, and K. Fabianowska-Majewska. 2015. Sulforaphane alone and in combination with clofarabine epigenetically regulates the expression of DNA methylation-silenced tumour suppressor genes in human breast cancer cells. Journal of Nutrigenetics and Nutrigenomics 8 (2):91–101. doi: 10.1159/000439111.
  • Lu, X., Y. Deng, D. Yu, H. Cao, L. Wang, L. Liu, C. Yu, Y. Zhang, X. Guo, and G. Yu. 2014. Histone acetyltransferase p300 mediates histone acetylation of PS1 and BACE1 in a cellular model of Alzheimer's disease. PLoS One 9 (7):e103067. doi: 10.1371/journal.pone.0103067.
  • Lu, B., M. Hu, K. Liu, and J. Peng. 2010. Cytotoxicity of berberine on human cervical carcinoma HeLa cells through mitochondria, death receptor and MAPK pathways, and in-silico drug-target prediction. Toxicol In Vitro 24 (6):1482–90. doi: 10.1016/j.tiv.2010.07.017.
  • Luna, R. C. P., M. K. dos Santos Nunes, M. G. C. A. Monteiro, C. S. O. da Silva, R. A. F. do Nascimento, R. P. A. Lima, F. C. F. Pimenta, N. F. P. de Oliveira, D. C. Persuhn, A. T. C. de Almeida, et al. 2018. α-Tocopherol influences glycaemic control and miR-9-3 DNA methylation in overweight and obese women under an energy-restricted diet: A randomized, double-blind, exploratory, controlled clinical trial. Nutrition & Metabolism 15 (1):49. doi: 10.1186/s12986-018-0286-7.
  • Lu, J., L. Zhang, X. Chen, Q. Lu, Y. Yang, J. Liu, and X. Ma. 2014. SIRT1 counteracted the activation of STAT3 and NF-kappaB to repress the gastric cancer growth. International Journal of Clinical and Experimental Medicine 7 (12):5050–8. PMID: 25664004.
  • Lyko, F. 2018. The DNA methyltransferase family: A versatile toolkit for epigenetic regulation. Nature Reviews Genetics 19 (2):81–92. doi: 10.1038/nrg.2017.80.
  • Ma, L., R. Fu, Z. Duan, J. Lu, J. Gao, L. Tian, Z. Lv, Z. Chen, J. Han, L. Jia, et al. 2016. Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat. Pathology, Research and Practice 212 (4):310–8. doi: 10.1016/j.prp.2016.02.001.
  • Macfarlane, L. A., and P. R. Murphy. 2010. MicroRNA: Biogenesis, function and role in cancer. Current Genomics 11 (7):537–61. doi: 10.2174/138920210793175895.
  • Madalena, D. A. S., R. N. C. Pereira, A. A. Vicente, and Ó. L. S. Ramos. 2019. New insights on bio-based micro-and nanosystems in food. In Reference module in food science - Encyclopedia of food chemistry, ed. L. Melton, F. Shahidi and P. Varelis, 708–14. Amsterdam, Netherlands: Elsevier B. V. ISBN: 978-0-08-100596-5. doi: B978-0-08-100596-5.21859-3.
  • Marconett, C. N., S. N. Sundar, M. Tseng, A. S. Tin, K. Q. Tran, K. M. Mahuron, L. F. Bjeldanes, and G. L. Firestone. 2011. Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells. Carcinogenesis 32 (9):1315–23. doi: 10.1093/carcin/bgr116.
  • Martelli, A., L. Testai, A. Colletti, and A. F. Cicero. 2020. Coenzyme Q10: Clinical applications in cardiovascular diseases. Antioxidants 9 (4):341. doi: 10.3390/antiox9040341.
  • Martín, R., S. Miquel, J. Ulmer, N. Kechaou, P. Langella, and L. G. Bermúdez-Humarán. 2013. Role of commensal and probiotic bacteria in human health: A focus on inflammatory bowel disease. Microbial Cell Factories 12 (1):71. doi: 10.1186/1475-2859-12-71. PMCID: PMC3726476.
  • Martin, S. L., R. Kala, and T. O. Tollefsbol. 2018. Mechanisms for the inhibition of colon cancer cells by sulforaphane through epigenetic modulation of microRNA-21 and human telomerase reverse transcriptase (hTERT) down-regulation. Current Cancer Drug Targets 18 (1):97–106. doi: 10.2174/1568009617666170206104032.
  • Matsuura, H. N., and A. G. Fett-Neto. 2015. Plant alkaloids: Main features, toxicity, and mechanisms of action. Plant Toxins :1–15. doi: 10.1007/978-94-007-6728-7_2-1.
  • Maugeri, A., M. G. Mazzone, F. Giuliano, M. Vinciguerra, G. Basile, M. Barchitta, and A. Agodi. 2018. Curcumin modulates DNA methyltransferase functions in a cellular model of diabetic retinopathy. Oxidative Medicine and Cellular Longevity 2018:1–12. doi: 10.1155/2018/5407482.
  • Melnik, B. C. 2015. Milk: An epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases. Journal of Translational Medicine 13 (1):385. doi: 10.1186/s12967-015-0746-z.
  • Melnik, B. C., S. M. John, P. Carrera-Bastos, and G. Schmitz. 2016b. Milk: A postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation. Clinical and Translational Allergy 6 (1):18. doi: 10.1186/s13601-016-0108-9.
  • Melnik, B. C., S. M. John, and G. Schmitz. 2014. Milk: An exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy? Journal of Translational Medicine 12 (1):43. doi: 10.1186/1479-5876-12-43.
  • Melnik, B. C., S. M. John, and G. Schmitz. 2016a. Milk: An epigenetic inducer of FoxP3 expression. The Journal of Allergy and Clinical Immunology 138 (3):937–8. doi: 10.1016/j.jaci.2016.04.039.
  • Mirza, S., G. Sharma, R. Parshad, S. D. Gupta, P. Pandya, and R. Ralhan. 2013. Expression of DNA methyltransferases in breast cancer patients and to analyze the effect of natural compounds on DNA methyltransferases and associated proteins. Journal of Breast Cancer 16 (1):23–31. doi: 10.4048/jbc.2013.16.1.23.
  • Mudd, A. T., L. S. Alexander, S. K. Johnson, C. M. Getty, O. V. Malysheva, M. A. Caudill, and R. N. Dilger. 2016. Perinatal dietary choline deficiency in sows influences concentrations of choline metabolites, fatty acids, and amino acids in milk throughout lactation. The Journal of Nutrition 146 (11):2216–23. doi: 10.3945/jn.116.238832.
  • Najar, R. A., N. A. Wani, J. A. Bhat, N. J. Dar, B. Rahat, A. P. Gupta, J. Kaur, J. Kaur, and A. Hamid. 2018. Modulation of dietary folate with age confers selective hepatocellular epigenetic imprints through DNA methylation. The Journal of Nutritional Biochemistry 53:121–32. doi: 10.1016/j.jnutbio.2017.10.007.
  • Nian, H., B. Delage, E. Ho, and R. H. Dashwood. 2009. Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. Environmental and Molecular Mutagenesis 50 (3):213–21. doi: 10.1002/em.20454.
  • Ortega, A. M. M., and M. R. S. Campos. 2019. Bioactive compounds as therapeutic alternatives. In Bioactive compounds, 247–64. Cambridge, England: Woodhead Publishing. eBook ISBN: 9780128147757.
  • Padi, S. K., Q. Zhang, Y. M. Rustum, C. Morrison, and B. Guo. 2013. MicroRNA-627 mediates the epigenetic mechanisms of vitamin D to suppress proliferation of human colorectal cancer cells and growth of xenograft tumors in mice. Gastroenterology 145 (2):437–46. doi: 10.1053/j.gastro.2013.04.012.
  • Pan, B., J. Quan, L. Liu, Z. Xu, J. Zhu, X. Huang, and J. Tian. 2017. Epigallocatechin gallate reverses cTnI-low expression-induced age-related heart diastolic dysfunction through histone acetylation modification. Journal of Cellular and Molecular Medicine 21 (10):2481–90. doi: 10.1111/jcmm.13169.
  • Pan, W., H. Yu, S. Huang, and P. Zhu. 2016. Resveratrol protects against TNF-α-induced injury in human umbilical endothelial cells through promoting sirtuin-1-induced repression of NF-KB and p38 MAPK. PLoS One 11 (1):e0147034. doi: 10.1371/journal.pone.0147034.
  • Parigi, S. M., M. Eldh, P. Larssen, S. Gabrielsson, and E. J. Villablanca. 2015. Breast milk and solid food shaping intestinal immunity. Frontiers in Immunology 6:415. doi: 10.3389/fimmu.2015.00415.
  • Park, J., M. Kim, S. G. Kang, A. H. Jannasch, B. Cooper, J. Patterson, and C. H. Kim. 2015. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunology 8 (1):80–93. doi: 10.1038/mi.2014.44.
  • Park, Y. W., and M. S. Nam. 2015. Bioactive peptides in milk and dairy products: A review. Korean Journal for Food Science of Animal Resources 35 (6):831–40. doi: 10.5851/kosfa.2015.35.6.831.
  • Park, J. E., Y. Sun, S. K. Lim, J. P. Tam, M. Dekker, H. Chen, and S. K. Sze. 2017. Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers. Scientific Reports 7 (1):40569– 13. doi: 10.1038/srep40569.
  • Paul, B., Y. Li, and T. O. Tollefsbol. 2018. The effects of combinatorial genistein and sulforaphane in breast tumor inhibition: Role in epigenetic regulation. International Journal of Molecular Sciences 19 (6):1754. doi: 10.3390/ijms19061754.
  • Pavan, A. R., G. D. B. D. Silva, D. H. Jornada, D. E. Chiba, G. F. D. S. Fernandes, C. M. Chin, and J. L. Dos Santos. 2016. Unraveling the anticancer effect of curcumin and resveratrol. Nutrients 8 (11):628. doi: 10.3390/nu8110628.
  • Pelosi, A., S. Careccia, G. Sagrestani, S. Nanni, I. Manni, V. Schinzari, J. H. A. Martens, A. Farsetti, H. G. Stunnenberg, M. P. Gentileschi, et al. 2014. Dual promoter usage as regulatory mechanism of let-7c expression in leukemic and solid tumors. Molecular Cancer Research: MCR 12 (6):878–89. doi: 10.1158/1541-7786.MCR-13-0410.
  • Peng, D., G. Ge, Y. Gong, Y. Zhan, S. He, B. Guan, Y. Li, Z. Xu, H. Hao, Z. He, et al. 2018. Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer. Clinical Epigenetics 10 (1):94. doi: 10.1186/s13148-018-0527-7.
  • Porter, N. J., and D. W. Christianson. 2017. Binding of the microbial cyclic tetrapeptide trapoxin A to the class I histone deacetylase HDAC8. ACS Chemical Biology 12 (9):2281–6. doi: 10.1021/acschembio.7b00330.
  • Prasad, S., S. C. Gupta, A. K. Tyagi, and B. B. Aggarwal. 2014. Curcumin, a component of golden spice: From bedside to bench and back. Biotechnology Advances 32 (6):1053–64. doi: 10.1016/j.biotechadv.2014.04.004.
  • Pulido-Moran, M., J. Moreno-Fernandez, C. Ramirez-Tortosa, and M. Ramirez-Tortosa. 2016. Curcumin and health. Molecules (Basel, Switzerland) 21 (3):264. doi: 10.3390/molecules21030264.
  • Qu, K., X. F. Ma, G. H. Li, H. Zhang, Y. M. Liu, K. Zhang, J. F. Zeng, J. J. Lei, D. H. Wei, and Z. Wang. 2017. Vitamin C down-regulate apo(a) expression via Tet2-dependent DNA demethylation in HepG2 cells. International Journal of Biological Macromolecules 98:637–45. doi: 10.1016/j.ijbiomac.2017.02.025.
  • Rajendran, P., A. I. Kidane, T. W. Yu, W. M. Dashwood, W. H. Bisson, C. V. Löhr, E. Ho, D. E. Williams, and R. H. Dashwood. 2013. HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics 8 (6):612–23. doi: 10.4161/epi.24710.
  • Remely, M., F. Ferk, S. Sterneder, T. Setayesh, T. Kepcija, S. Roth, R. Noorizadeh, M. Greunz, I. Rebhan, K. H. Wagner, et al. 2017. Vitamin E modifies high-fat diet-induced increase of DNA strand breaks, and changes in expression and DNA methylation of Dnmt1 and MLH1 in C57BL/6J male mice. Nutrients 9 (6):607. doi: 10.3390/nu9060607.
  • Reuter, S., S. C. Gupta, B. Park, A. Goel, and B. B. Aggarwal. 2011. Epigenetic changes induced by curcumin and other natural compounds. Genes & Nutrition 6 (2):93–108. doi: 10.1007/s12263-011-0222-1.
  • Rodríguez-Nogales, A., F. Algieri, J. Garrido-Mesa, T. Vezza, M. P. Utrilla, N. Chueca, J. A. Fernández-Caballero, F. García, M. E. Rodríguez-Cabezas, and J. Gálvez. 2018. The administration of Escherichia coli Nissle 1917 ameliorates development of DSS-induced colitis in mice. Frontiers in Pharmacology 9:468. doi: 10.3389/fphar.2018.00468.
  • Roy, D. G., J. Chen, V. Mamane, E. H. Ma, B. M. Muhire, R. D. Sheldon, T. Shorstova, R. Koning, R. M. Johnson, E. Esaulova, et al. 2020. Methionine metabolism shapes T helper cell responses through regulation of epigenetic reprogramming. Cell Metabolism 31 (2):250–66. doi: 10.1016/j.cmet.2020.01.006.
  • Royston, K. J., N. Udayakumar, K. Lewis, and T. O. Tollefsbol. 2017. A novel combination of withaferin A and sulforaphane inhibits epigenetic machinery, cellular viability and induces apoptosis of breast cancer cells. International Journal of Molecular Sciences 18 (5):1092. doi: 10.3390/ijms18051092.
  • Saha, S. K., and A. R. Khuda-Bukhsh. 2014. Berberine alters epigenetic modifications, disrupts microtubule network, and modulates HPV-18 E6-E7 oncoproteins by targeting p53 in cervical cancer cell HeLa: a mechanistic study including molecular docking. European Journal of Pharmacology 744:132–46. doi: 10.1016/j.ejphar.2014.09.048.
  • Saldanha, E., N. Joseph, R. Ravi, A. Kumar, V. Shetty, R. Fayad, and M. S. Baliga. 2014. Polyphenols in the prevention of acute pancreatitis: Preclinical observations. In Polyphenols in human health and disease, vol. 1, 427–33. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-398456-2.00031-1.
  • Sawda, C., C. Moussa, and R. S. Turner. 2017. Resveratrol for Alzheimer's disease. Annals of the New York Academy of Sciences 1403 (1):142–9. doi: 0.1111/nyas.13431. doi: 10.1111/nyas.13431.
  • Sayeed, M. A., M. Bracci, R. Lazzarini, M. Tomasetti, M. Amati, G. Lucarini, R. D. Primio, and L. Santarelli. 2017. Use of potential dietary phytochemicals to target miRNA: Promising option for breast cancer prevention and treatment? Journal of Functional Foods 28:177–93. doi: 10.1016/j.jff.2016.11.008.
  • Schnekenburger, M., and M. Diederich. 2015. Nutritional epigenetic regulators in the field of cancer: New avenues for chemopreventive approaches. In Epigenetic Cancer Therapy, 393–25. Academic Press. doi: 10.1016/B978-0-12-800206-3.00018-5.
  • Schulthess, J., S. Pandey, M. Capitani, K. C. Rue-Albrecht, I. Arnold, F. Franchini, A. Chomka, N. E. Ilott, D. G. W. Johnston, E. Pires, et al. 2019. The short chain fatty acid butyrate imprints an antimicrobial program in macrophages. Immunity 50 (2):432–45. doi: 10.1016/j.immuni.2018.12.018.
  • Sestili, P., and C. Fimognari. 2015. Cytotoxic and antitumor activity of sulforaphane: The role of reactive oxygen species. BioMed Research International 2015:402386. doi: 10.1155/2015/402386.
  • Sharma, M., and G. Shukla. 2016. Metabiotics: One step ahead of probiotics; an insight into mechanisms involved in anticancerous effect in colorectal cancer. Frontiers in Microbiology 7:1940. doi: 10.3389/fmicb.2016.01940.
  • Sin, T. K., B. T. Tam, B. Y. Yung, S. P. Yip, L. W. Chan, C. S. Wong, M. Ying, J. A. Rudd, and P. M. Siu. 2015. Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis. Journal of Physiology (London.) 593 (8):1887–99. doi: 10.1113/jphysiol.2014.270101.
  • Singh, C. K., X. Liu, and N. Ahmad. 2015. Resveratrol, in its natural combination in whole grape, for health promotion and disease management. Annals of the New York Academy of Sciences 1348 (1):150–60. doi: 10.1111/nyas.12798.
  • Sinha, S., S. Shukla, S. Khan, T. O. Tollefsbol, and S. M. Meeran. 2015. Epigenetic reactivation of p21CIP1/WAF1 and KLOTHO by a combination of bioactive dietary supplements is partially ERα-dependent in ERα-negative human breast cancer cells. Molecular and Cellular Endocrinology 406:102–14. doi: 10.1016/j.mce.2015.02.020.
  • Soshnev, A. A., S. Z. Josefowicz, and C. D. Allis. 2016. Greater than the sum of parts: Complexity of the dynamic epigenome. Molecular Cell 62 (5):681–94. doi: 10.1016/j.molcel.2016.05.004.
  • Sowmya, K., M. I. Bhat, R. K. Bajaj, S. Kapila, and R. Kapila. 2019. Buffalo milk casein derived decapeptide (YQEPVLGPVR) having bifunctional anti-inflammatory and antioxidative features under cellular milieu. International Journal of Peptide Research and Therapeutics 25 (2):623–33. doi: 10.1007/s10989-018-9708-7.
  • Spagnuolo, C., G. L. Russo, I. E. Orhan, S. Habtemariam, M. Daglia, A. Sureda, S. F. Nabavi, K. P. Devi, M. R. Loizzo, R. Tundis, et al. 2015. Genistein and cancer: Current status, challenges, and future directions. Advances in Nutrition (Bethesda, Md.) 6 (4):408–19. doi: 10.3945/an.114.008052.
  • Sui, X., H. Wei, and D. Wang. 2015. Novel mechanism of cardiac protection by valsartan: Synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction. Journal of Cellular and Molecular Medicine 19 (8):1773–82. doi: 10.1111/jcmm.12551.
  • Sun, Q., R. Cong, H. Yan, H. Gu, Y. Zeng, N. Liu, J. Chen, and B. Wang. 2009. Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression. Oncology Reports 22 (3):563–7. doi: 10.3892/or_00000472.
  • Sun, M., Q. Zhang, X. Yang, S. Y. Qian, and B. Guo. 2016. Vitamin D Enhances the Efficacy of Irinotecan through miR-627-Mediated Inhibition of Intratumoral Drug Metabolism. Molecular Cancer Therapeutics 15 (9):2086–95. doi: 10.1158/1535-7163.mct-16-0095.
  • Su, B., S. L. Xiang, J. Su, H. L. Tang, Q. J. Liao, Y. J. Zhou, and Q. Su. 2012. Diallyl disulfide increases histone acetylation and P21WAF1 expression in human gastric cancer cells in vivo and in vitro. Biochemical Pharmacology 1 (7):1–10. doi: 10.4172/2167-0501.1000106.
  • Su, Z. Y., C. Zhang, J. H. Lee, L. Shu, T. Y. Wu, T. O. Khor, A. H. Conney, Y. P. Lu, and A. N. T. Kong. 2014. Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane. Cancer Prevention Research (Philadelphia, Pa.) 7 (3):319–29. doi: 10.1158/1940-6207.capr-13-0313-t.
  • Szulwach, K. E., and P. Jin. 2014. Integrating DNA methylation dynamics into a framework for understanding epigenetic codes. BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology 36 (1):107–17. doi: 10.1002/bies.201300090.
  • Tang, H., Y. Kong, J. Guo, Y. Tang, X. Xie, L. Yang, Q. Su, and X. Xie. 2013. Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22. Cancer Letters 340 (1):72–81. doi: 10.1016/j.canlet.2013.06.027.
  • Tang, F., D. Wang, C. Duan, D. Huang, Y. Wu, Y. Chen, W. Wang, C. Xie, J. Meng, L. Wang, et al. 2009. Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting Rho kinase-mediated Ezrin phosphorylation at threonine 567. The Journal of Biological Chemistry 284 (40):27456–66. doi: 10.1074/jbc.m109.033795.
  • Tasselli, L., W. Zheng, and K. F. Chua. 2017. SIRT6: Novel mechanisms and links to aging and disease. Trends in Endocrinology and Metabolism: TEM 28 (3):168–85. doi: 10.1016/j.tem.2016.10.002.
  • Tehlivets, O., N. Malanovic, M. Visram, T. Pavkov-Keller, and W. Keller. 2013. S-adenosyl-l-homocysteine hydrolase and methylation disorders: Yeast as a model system. Biochimica et Biophysica Acta 1832 (1):204. doi: 10.1016/j.bbadis.2012.09.007.
  • Tomar, S., M. Nagarkatti, and P. S. Nagarkatti. 2015. 3,3'-Diindolylmethane attenuates LPS-mediated acute liver failure by regulating miRNAs to target IRAK4 and suppress Toll-like receptor signalling. British Journal of Pharmacology 172 (8):2133–47. doi: 10.1111/bph.13036.
  • Traber, M. G., and J. F. Stevens. 2011. Vitamins C and E: Beneficial effects from a mechanistic perspective. Free Radical Biology & Medicine 51 (5):1000–13. doi: 10.1016/j.freeradbiomed.2011.05.017.
  • Trivedi, M. S., J. S. Shah, S. Al-Mughairy, N. W. Hodgson, B. Simms, G. A. Trooskens, W. Van Criekinge, and R. C. Deth. 2014. Food-derived opioid peptides inhibit cysteine uptake with redox and epigenetic consequences. The Journal of Nutritional Biochemistry 25 (10):1011–8. doi: 10.1016/j.jnutbio.2014.05.004.
  • Trivedi, M., Y. Zhang, M. Lopez-Toledano, A. Clarke, and R. Deth. 2016. Differential neurogenic effects of casein-derived opioid peptides on neuronal stem cells: Implications for redox-based epigenetic changes. The Journal of Nutritional Biochemistry 37:39–46. doi: 10.1016/j.jnutbio.2015.10.012.
  • Udenigwe, C. C., and R. E. Aluko. 2012. Food protein-derived bioactive peptides: production, processing, and potential health benefits. Journal of Food Science 77 (1):R11–R24. doi: 10.1111/j.1750-3841.2011.02455.x.
  • Vahid, F., H. Zand, E. Nosrat–Mirshekarlou, R. Najafi, and A. Hekmatdoost. 2015. The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: A review. Gene 562 (1):8–15. doi: 10.1016/j.gene.2015.02.045.
  • Vallianou, N. G., A. Evangelopoulos, and C. Kazazis. 2013. Resveratrol and diabetes. The Review of Diabetic Studies: RDS 10 (4):236–42. doi: 10.1900/rds.2013.10.236.
  • Venkatadri, R., T. Muni, A. K. Iyer, J. S. Yakisich, and N. Azad. 2016. Role of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death. Cell Death & Disease 7 (2):e2104. doi: 10.1038/cddis.2016.6.
  • Wada, T. T., Y. Araki, K. Sato, Y. Aizaki, K. Yokota, Y. T. Kim, H. Oda, R. Kurokawa, and T. Mimura. 2014. Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts. Biochemical and Biophysical Research Communications 444 (4):682–6. doi: 0.1016/j.bbrc.2014.01.195. doi: 10.1016/j.bbrc.2014.01.195.
  • Waddington, C. H. 2012. The epigenotype. 1942. International Journal of Epidemiology 41 (1):10–‐3. doi: 10.1093/ije/dyr184.
  • Wang, K. C., and H. Y. Chang. 2011. Molecular mechanisms of long noncoding RNAs. Molecular Cell 43 (6):904–14. doi: 10.1016/j.molcel.2011.08.018.
  • Wang, P., F. Fan, X. Li, X. Sun, L. Ma, J. Wu, C. Shen, H. Zhu, Z. Dong, C. Wang, et al. 2018. Riboflavin attenuates myocardial injury via LSD1-mediated crosstalk between phospholipid metabolism and histone methylation in mice with experimental myocardial infarction. Journal of Molecular and Cellular Cardiology 115:115–29. doi: 10.1016/j.yjmcc.2018.01.006.
  • Wang, Y., W. Gong, S. Lv, H. Qu, and Y. He. 2019. Berberine improves insulin resistance in adipocyte models by regulating the methylation of hypoxia-inducible factor-3α. Bioscience Reports 39 (10):10. doi: 10.1042/BSR20192059.
  • Wang, H., Y. J. Jo, J. S. Oh, and N. H. Kim. 2017. Quercetin delays postovulatory aging of mouse oocytes by regulating SIRT expression and MPF activity. Oncotarget 8 (24):38631–41. doi: 0.18632/oncotarget.16219. doi: 10.18632/oncotarget.16219.
  • Wang, X., Y. Li, Y. Dai, Q. Liu, S. Ning, J. Liu, Z. Shen, D. Zhu, F. Jiang, J. Zhang, et al. 2016. Sulforaphane improves chemotherapy efficacy by targeting cancer stem cell-like properties via the miR-124/IL-6R/STAT3 axis. Scientific Reports 6 (1):36796. doi: 10.1038/srep36796.
  • Wang, G., G. Liu, Y. Ye, Y. Fu, and X. Zhang. 2016. Upregulation of miR-34a by diallyl disulfide suppresses invasion and induces apoptosis in SGC-7901 cells through inhibition of the PI3K/Akt signaling pathway. Oncology Letters 11 (4):2661–7. doi: 10.3892/ol.2016.4266.
  • Wang, J., N. Yin, Y. Deng, Y. Wei, Y. Huang, X. Pu, L. Li, Y. Zheng, J. Guo, J. Yu, et al. 2016. Ascorbic acid protects against hypertension through downregulation of ACE1 gene expression mediated by histone deacetylation in prenatal inflammation-induced offspring. Scientific Reports 6:39469. doi: 10.1038/srep39469.
  • Wang, L. J., H. W. Zhang, J. Y. Zhou, Y. Liu, Y. Yang, X. L. Chen, C. H. Zhu, R. D. Zheng, W. H. Ling, and H. L. Zhu. 2014. Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet. The Journal of Nutritional Biochemistry 25 (3):329–36. doi: 10.1016/j.jnutbio.2013.11.007.
  • Wei, J. W., K. Huang, C. Yang, and C. S. Kang. 2017. Non-coding RNAs as regulators in epigenetics (Review). Oncology Reports 37 (1):3–9. doi: 10.3892/or.2016.5236.
  • Wu, T. Y., T. O. Khor, Z. Y. Su, C. L. L. Saw, L. Shu, K. L. Cheung, Y. Huang, S. Yu, and A. N. T. Kong. 2013. Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors . The AAPS Journal 15 (3):864–74. doi: 10.1208/s12248-013-9493-3.
  • Wu, Y. C., X. Liu, J. L. Wang, X. L. Chen, L. Lei, J. Han, Y. S. Jiang, and Z. Q. Ling. 2016. Soft-shelled turtle peptide modulates microRNA profile in human gastric cancer AGS cells. Oncology Letters 15 (3):3109–20. doi: 10.3892/ol.2017.7692.
  • Wu, M. J., M. R. Kim, Y. S. Chen, J. Y. Yang, and C. J. Chang. 2017. Retinoic acid directs breast cancer cell state changes through regulation of TET2-PKCζ pathway. Oncogene 36 (22):3193–206. doi: 10.1038/onc.2016.467.
  • Wu, X., Y. Wu, L. He, L. Wu, X. Wang, and Z. Liu. 2018. Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer. Journal of Cancer 9 (14):2510–7. doi: 10.7150/jca.25324.
  • Xiang, Y., N. Ma, D. Wang, Y. Zhang, J. Zhou, G. Wu, R. Zhao, H. Huang, X. Wang, Y. Qiao, et al. 2014. MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: A novel epigenetic therapy independent of decitabine. Oncogene 33 (3):378–86. doi: 10.1038/onc.2012.575.
  • Xiao, X., B. Chen, X. Liu, P. Liu, G. Zheng, F. Ye, H. Tang, and X. Xie. 2014. Diallyl Disulfide Suppresses SRC/Ras/ERK Signaling-Mediated Proliferation and Metastasis in Human Breast Cancer by Up-Regulating miR-34a. PLoS ONE 9 (11):e112720. doi: 10.1371/journal.pone.0112720.
  • Xu, Y., D. Su, L. Zhu, S. Zhang, S. Ma, K. Wu, Q. Yuan, and N. Lin. 2018. S-allylcysteine suppresses ovarian cancer cell proliferation by DNA methylation through DNMT1. Journal of Ovarian Research 11 (1):39. doi: 10.1186/s13048-018-0412-1.
  • Xu, L., J. Xiang, J. Shen, X. Zou, S. Zhai, Y. Yin, P. Li, X. Wang, and Q. Sun. 2013. Oncogenic MicroRNA-27a is a target for genistein in ovarian cancer cells. Anti-Cancer Agents in Medicinal Chemistry 13 (7):1126–32. doi: 10.2174/18715206113139990006.
  • Yang, S. F., W. J. Lee, P. Tan, C. H. Tang, M. Hsiao, F. K. Hsieh, and M. H. Chien. 2015. Upregulation of mir-328 and inhibition of creb-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas. Oncotarget 6 (5):2736–53. doi: 10.18632/oncotarget.3088.
  • Yang, S., W. Li, H. Sun, B. Wu, F. Ji, T. Sun, H. Chang, P. Shen, Y. Wang, and D. Zhou. 2015. Resveratrol elicits anti-colorectal cancer effect by activating miR-34c-KITLG in vitro and in vivo. BMC Cancer 15 (1):969. doi: 10.1186/s12885-015-1958-6.
  • Yang, Y., A. Zang, Y. Jia, Y. Shang, Z. Zhang, K. Ge, J. Zhang, W. Fan, and B. Wang. 2016. Genistein inhibits A549 human lung cancer cell proliferation via miR-27a and MET signaling. Oncology Letters 12 (3):2189–93. doi: 10.3892/ol.2016.4817.
  • Yang, X. H., B. L. Zhang, X. M. Zhang, J. D. Tong, Y. H. Gu, L. L. Guo, and H. M. Jin. 2020. EGCG attenuates renal damage via reversing klotho hypermethylation in diabetic db/db mice and HK-2 cells. Oxidative Medicine and Cellular Longevity 2020:6092715. doi: 10.1155/2020/6092715.
  • Yun, J. M., I. Jialal, and S. Devaraj. 2011. Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin. The Journal of Nutritional Biochemistry 22 (5):450–8. doi: 10.1016/j.jnutbio.2010.03.014.
  • Zamani, M., M. Sadeghizadeh, M. Behmanesh, and F. Najafi. 2015. Dendrosomal curcumin increases expression of the long non coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer. Phytomedicine 22 (10):961–7. doi: 10.1016/j.phymed.2015.05.071.
  • Zappe, K., A. Pointner, O. J. Switzeny, U. Magnet, E. Tomeva, J. Heller, G. Mare, K. H. Wagner, S. Knasmueller, and A. G. Haslberger. 2018. Counteraction of oxidative stress by vitamin E affects epigenetic regulation by increasing global methylation and gene expression of MLH1 and DNMT1 dose dependently in Caco-2 cells. Oxidative Medicine and Cellular Longevity 2018:3734250. doi: 10.1155/2018/3734250.
  • Zhang, X.-N., J. Liu, Y. Liu, Y. Wang, A. Abozeid, Z.-G. Yu, and Z.-H. Tang. 2018. Metabolomics analysis reveals that ethylene and methyl jasmonate regulate different branch pathways to promote the accumulation of terpenoid indole alkaloids in Catharanthus roseus. Journal of Natural Products 81 (2):335–42. doi:10.1021/acs.jnatprod.7b00782. 29406718
  • Zhang, N. 2018. Role of methionine on epigenetic modification of DNA methylation and gene expression in animals. Animal Nutrition (Zhongguo xu mu Shou yi Xue Hui) 4 (1):11–6. doi: 10.1016/j.aninu.2017.08.009.
  • Zhang, W., W. Bai, and W. Zhang. 2014. MiR-21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non-small cell lung cancer A549 cells. Clinical and Translational Oncology 16 (8):708–13. doi: 10.1007/s12094-013-1135-9.
  • Zhang, Y., X. Cao, W. Zhu, Z. Liu, H. Liu, Y. Zhou, Y. Cao, C. Liu, and Y. Xie. 2016. Resveratrol enhances autophagic flux and promotes Ox-LDL degradation in HUVECs via upregulation of SIRT1. Oxidative Medicine and Cellular Longevity 2016:7589813. doi: 10.1155/2016/7589813.
  • Zhang, E., Q. Guo, H. Gao, R. Xu, S. Teng, and Y. Wu. 2015. Metformin and resveratrol inhibited high glucose-induced metabolic memory of endothelial senescence through SIRT1/p300/p53/p21 pathway. PLoS ONE 10 (12):e0143814. doi: 10.1371/journal.pone.0143814.
  • Zhang, W., W. Zhang, L. Sun, L. Xiang, X. Lai, Q. Li, and S. Sun. 2019. The effects and mechanisms of epigallocatechin-3-gallate on reversing multidrug resistance in cancer. Trends in Food Science & Technology 93:221–3. doi: 10.1016/j.tifs.2019.09.017.
  • Zhang, H., Z. Zhao, X. Pang, J. Yang, H. Yu, Y. Zhang, H. Zhou, and J. Zhao. 2017. Genistein protects against Ox-LDL-induced inflammation through microRNA-155/SOCS1-mediated repression of NF-ĸB signaling pathway in HUVECs. Inflammation 40 (4):1450–9. doi: 10.1007/s10753-017-0588-3.
  • Zhao, Y., F. J. Monahan, B. A. McNulty, M. J. Gibney, and E. R. Gibney. 2014. Effect of vitamin E intake from food and supplement sources on plasma α- and γ-tocopherol concentrations in a healthy Irish adult population. The British Journal of Nutrition 112 (9):1575–85. doi: 10.1017/s0007114514002438.
  • Zhao, F., J. Zhang, and N. Chang. 2018. Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease. European Journal of Pharmacology 824:1–10. doi: 10.1016/j.ejphar.2018.01.046.
  • Zhou, X., M. Chen, X. Zeng, J. Yang, H. Deng, L. Yi, and M. Mi. 2014. Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells. Cell Death & Disease 5:e1576. doi: 10.1038/cddis.2014.530.
  • Zhu, K., and W. Wang. 2016. Green tea polyphenol egcg suppresses osteosarcoma cell growth through upregulating mir-1. Tumor Biology 37 (4):4373–82. doi: 10.1007/s13277-015-4187-3.
  • Zitman-Gal, T., J. Green, M. Pasmanik-Chor, E. Golan, J. Bernheim, and S. Benchetrit. 2014. Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment. Cardiovascular Diabetology 13 (1):8. doi: 10.1186/1475-2840-13-8.

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