Plant extracts in prevention of obesity

References

• Aguirre, L., A. Fernandez-Quintela, N. Arias, and M. P. Portillo. 2014. Resveratrol: Anti-obesity mechanisms of action. Molecules (Basel, Switzerland) 19 (11):18632–55. doi: 10.3390/molecules191118632.
   PubMed Web of Science ®Google Scholar
• Ahn, J., H. Lee, S. Kim, and T. Ha. 2010. Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/beta-catenin signaling. American Journal of Physiology. Cell Physiology 298 (6):C1510–C1516. doi: 10.1152/ajpcell.00369.2009.
   PubMed Web of Science ®Google Scholar
• Ahn, J., H. Lee, S. Kim, J. Park, and T. Ha. 2008. The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochemical and Biophysical Research Communications 373 (4):545–9. doi: 10.1016/j.bbrc.2008.06.077.
   PubMed Web of Science ®Google Scholar
• Alberdi, G., V. M. Rodriguez, J. Miranda, M. T. Macarulla, N. Arias, C. Andres-Lacueva, and M. P. Portillo. 2011. Changes in white adipose tissue metabolism induced by resveratrol in rats. Nutrition & Metabolism 8 (1):29. doi: 10.1186/1743-7075-8-29.
   PubMed Web of Science ®Google Scholar
• Alberdi, G., V. M. Rodriguez, J. Miranda, M. T. Macarulla, I. Churruca, and M. P. Portillo. 2013. Thermogenesis is involved in the body-fat lowering effects of resveratrol in rats. Food Chemistry 141 (2):1530–5. doi: 10.1016/j.foodchem.2013.03.085.
   PubMed Web of Science ®Google Scholar
• Arias, N., M. T. Macarulla, L. Aguirre, I. Milton, and M. P. Portillo. 2016. The combination of resveratrol and quercetin enhances the individual effects of these molecules on triacylglycerol metabolism in white adipose tissue. European Journal of Nutrition 55 (1):341–8. doi: 10.1007/s00394-015-0854-9.
   PubMed Web of Science ®Google Scholar
• Baskaran, P., V. Krishnan, J. Ren, and B. Thyagarajan. 2016. Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms. British Journal of Pharmacology 173 (15):2369–89. doi: 10.1111/bph.13514.
   PubMed Web of Science ®Google Scholar
• Betz, M. J., and S. Enerback. 2018. Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease. Nature Reviews. Endocrinology 14 (2):77–87. doi: 10.1038/nrendo.2017.132.
   PubMed Web of Science ®Google Scholar
• Bonet, M. L., J. A. Canas, J. Ribot, and A. Palou. 2015. Carotenoids and their conversion products in the control of adipocyte function, adiposity and obesity. Archives of Biochemistry and Biophysics 572:112–25. doi: 10.1016/j.abb.2015.02.022.
   PubMed Web of Science ®Google Scholar
• Carrasco-Pozo, C., M. J. Cires, and M. Gotteland. 2019. Quercetin and epigallocatechin gallate in the prevention and treatment of obesity: From molecular to clinical studies. Journal of Medicinal Food 22 (8):753–70. doi: 10.1089/jmf.2018.0193.
   PubMed Web of Science ®Google Scholar
• Casanova, E., J. Salvado, A. Crescenti, and A. Gibert-Ramos. 2019. Epigallocatechin gallate modulates muscle homeostasis in type 2 diabetes and obesity by targeting energetic and redox pathways: A narrative review. International Journal of Molecular Sciences 20 (3): 532. doi: 10.3390/ijms20030532.
   PubMed Web of Science ®Google Scholar
• Chang, C. J., T. F. Tzeng, S. S. Liou, Y. S. Chang, and I. M. Liu. 2011. Kaempferol regulates the lipid-profile in high-fat diet-fed rats through an increase in hepatic PPARα levels. Planta Medica 77 (17):1876–82. doi: 10.1055/s-0031-1279992.
   PubMed Web of Science ®Google Scholar
• Chen, I. J., C. Y. Liu, J. P. Chiu, and C. H. Hsu. 2016. Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial. Clinical Nutrition (Edinburgh, Scotland) 35 (3):592–9. doi: 10.1016/j.clnu.2015.05.003.
   PubMed Web of Science ®Google Scholar
• Chen, J., L. Li, Y. Li, X. Liang, Q. Sun, H. Yu, J. Zhong, Y. Ni, J. Chen, Z. Zhao, et al. 2015. Activation of TRPV1 channel by dietary capsaicin improves visceral fat remodeling through connexin43-mediated Ca2+ influx. Cardiovascular Diabetology 14:22. doi: 10.1186/s12933-015-0183-6.
   PubMed Web of Science ®Google Scholar
• Chen, Q., P. Shou, C. Zheng, M. Jiang, G. Cao, Q. Yang, J. Cao, N. Xie, T. Velletri, X. Zhang, et al. 2016. Fate decision of mesenchymal stem cells: Adipocytes or osteoblasts? Cell Death and Differentiation 23 (7):1128–39. doi: 10.1038/cdd.2015.168.
   PubMed Web of Science ®Google Scholar
• Choi, Y. R., J. Shim, and M. J. Kim. 2020. Genistin: A novel potent anti-adipogenic and anti-lipogenic agent. Molecules 25 (9):2042. doi: 10.3390/molecules25092042.
   PubMed Web of Science ®Google Scholar
• Chouchani, E. T., L. Kazak, and B. M. Spiegelman. 2019. New advances in adaptive thermogenesis: UCP1 and beyond. Cell Metabolism 29 (1):27–37. doi: 10.1016/j.cmet.2018.11.002.
   PubMed Web of Science ®Google Scholar
• Desjardins, E. M., and G. R. Steinberg. 2018. Emerging role of AMPK in Brown and Beige Adipose tissue (BAT): Implications for obesity, insulin resistance, and type 2 diabetes. Current Diabetes Reports 18 (10):80. doi: 10.1007/s11892-018-1049-6.
   PubMed Web of Science ®Google Scholar
• Ding, L. L., J. M. Li, B. L. Song, X. Xiao, B. F. Zhang, M. Qi, W. D. Huang, L. Yang, and Z. T. Wang. 2016. Curcumin rescues high fat diet-induced obesity and insulin sensitivity in mice through regulating SREBP pathway. Toxicology and Applied Pharmacology 304:99–109. doi: 10.1016/j.taap.2016.05.011.
   PubMed Web of Science ®Google Scholar
• Doan, K. V., C. M. Ko, A. W. Kinyua, D. J. Yang, Y. H. Choi, I. Y. Oh, N. M. Nguyen, A. Ko, J. W. Choi, Y. Jeong, et al. 2015. Gallic acid regulates body weight and glucose homeostasis through AMPK activation. Endocrinology 156 (1):157–68. doi: 10.1210/en.2014-1354.
   PubMed Web of Science ®Google Scholar
• Ejaz, A., D. Wu, P. Kwan, and M. Meydani. 2009. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. The Journal of Nutrition 139 (5):919–25. doi: 10.3945/jn.108.100966.
   PubMed Web of Science ®Google Scholar
• Fan, L., H. Xu, R. Yang, Y. Zang, J. Chen, and H. Qin. 2019. Combination of capsaicin and capsiate induces browning in 3T3-L1 white adipocytes via activation of the peroxisome proliferator-activated receptor gamma/beta3-adrenergic receptor signaling pathways. Journal of Agricultural and Food Chemistry 67 (22):6232–40. doi: 10.1021/acs.jafc.9b02191.
   PubMed Web of Science ®Google Scholar
• Fan, R., M. You, A. M. Toney, J. Kim, D. Giraud, Y. Xian, F. Ye, L. Gu, A. E. Ramer-Tait, and S. Chung. 2019. Red raspberry polyphenols attenuate high-fat diet-driven activation of NLRP3 inflammasome and its paracrine suppression of adipogenesis via histone modifications. Molecular Nutrition & Food Research 64 (15):1900995. doi: 10.1002/mnfr.201900995.
   Web of Science ®Google Scholar
• Floyd, Z. E., Z. Q. Wang, G. Kilroy, and W. T. Cefalu. 2008. Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol. Metabolism: Clinical and Experimental 57 (7 Suppl 1):S32–S38. doi: 10.1016/j.metabol.2008.04.006.
   PubMed Web of Science ®Google Scholar
• Forney, L. A., N. R. Lenard, L. K. Stewart, and T. M. Henagan. 2018. Dietary quercetin attenuates adipose tissue expansion and inflammation and alters adipocyte morphology in a tissue-specific manner. International Journal of Molecular Sciences 19 (3):895. doi: 10.3390/ijms19030895.
   Web of Science ®Google Scholar
• Funakoshi, T., N. Kanzaki, Y. Otsuka, T. Izumo, H. Shibata, and S. Machida. 2018. Quercetin inhibits adipogenesis of muscle progenitor cells in vitro. Biochemistry and Biophysics Reports 13:39–44. doi: 10.1016/j.bbrep.2017.12.003.
   PubMedGoogle Scholar
• Gabriel, B. M., and J. R. Zierath. 2017. The limits of exercise physiology: From performance to health. Cell Metabolism 25 (5):1000–11. doi: 10.1016/j.cmet.2017.04.018.
   PubMed Web of Science ®Google Scholar
• Gandhi, G. R., G. Jothi, P. J. Antony, K. Balakrishna, M. G. Paulraj, S. Ignacimuthu, A. Stalin, and N. A. Al-Dhabi. 2014. Gallic acid attenuates high-fat diet fed-streptozotocin-induced insulin resistance via partial agonism of PPARγ in experimental type 2 diabetic rats and enhances glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway. European Journal of Pharmacology 745:201–16. doi: 10.1016/j.ejphar.2014.10.044.
   PubMed Web of Science ®Google Scholar
• Goh, K. P., H. Y. Lee, D. P. Lau, W. Supaat, Y. H. Chan, and A. F. Koh. 2014. Effects of resveratrol in patients with type 2 diabetes mellitus on skeletal muscle SIRT1 expression and energy expenditure. International Journal of Sport Nutrition and Exercise Metabolism 24 (1):2–13. doi: 10.1123/ijsnem.2013-0045.
   PubMed Web of Science ®Google Scholar
• Gomez-Zorita, S., A. Lasa, N. Abendano, A. Fernandez-Quintela, A. Mosqueda-Solis, M. P. Garcia-Sobreviela, J. M. Arbones-Mainar, and M. P. Portillo. 2017. Phenolic compounds apigenin, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes. Journal of Translational Medicine 15 (1):237. doi: 10.1186/s12967-017-1343-0.
   PubMedGoogle Scholar
• Gomez-Zorita, S., K. Treguer, J. Mercader, and C. Carpene. 2013. Resveratrol directly affects in vitro lipolysis and glucose transport in human fat cells. Journal of Physiology and Biochemistry 69 (3):585–93. doi: 10.1007/s13105-012-0229-0.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Hurtado, E., J. Lee, J. Choi, and M. J. Wolfgang. 2018. Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing. Molecular Metabolism 7:45–56. doi: 10.1016/j.molmet.2017.11.004.
   PubMed Web of Science ®Google Scholar
• Gu, Q., Y. Cai, C. Huang, Q. Shi, and H. Yang. 2012. Curcumin increases rat mesenchymal stem cell osteoblast differentiation but inhibits adipocyte differentiation. Pharmacognosy Magazine 8 (31):202–8. doi: 10.4103/0973-1296.99285.
   PubMed Web of Science ®Google Scholar
• Gupta, R. K., R. J. Mepani, S. Kleiner, J. C. Lo, M. J. Khandekar, P. Cohen, A. Frontini, D. C. Bhowmick, L. Ye, S. Cinti, et al. 2012. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metabolism 15 (2):230–9. doi: 10.1016/j.cmet.2012.01.010.
   PubMed Web of Science ®Google Scholar
• Guri, A. J., R. Hontecillas, H. Si, D. Liu, and J. Bassaganya-Riera. 2007. Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets. Clinical Nutrition (Edinburgh, Scotland) 26 (1):107–16. doi: 10.1016/j.clnu.2006.07.008.
   PubMed Web of Science ®Google Scholar
• Hadrich, F., and S. Sayadi. 2018. Apigetrin inhibits adipogenesis in 3T3-L1 cells by downregulating PPAR gamma and CEBP-alpha. Lipids in Health and Disease 17 (1):95. doi: 10.1186/s12944-018-0738-0.
   PubMedGoogle Scholar
• Haemmerle, G., A. Lass, R. Zimmermann, G. Gorkiewicz, C. Meyer, J. Rozman, G. Heldmaier, R. Maier, C. Theussl, S. Eder, et al. 2006. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science (New York, N.Y.) 312 (5774):734–7. doi: 10.1126/science.1123965.
   PubMed Web of Science ®Google Scholar
• Hall, J. M., H. R. Powell, L. Rajic, and K. S. Korach. 2019. The role of dietary phytoestrogens and the nuclear receptor PPAR gamma in adipogenesis: An in vitro study (vol 127, 037007, 2019). Environmental Health Perspectives 127 (10). doi: 10.1289/Ehp3444.
   Google Scholar
• Harms, M., and P. Seale. 2013. Brown and beige fat: Development, function and therapeutic potential. Nature Medicine 19 (10):1252–63. doi: 10.1038/nm.3361.
   PubMed Web of Science ®Google Scholar
• Hondares, E., M. Rosell, J. Diaz-Delfin, Y. Olmos, M. Monsalve, R. Iglesias, F. Villarroya, and M. Giralt. 2011. Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: Involvement of PRDM16. The Journal of Biological Chemistry 286 (50):43112–22. doi: 10.1074/jbc.M111.252775.
   PubMed Web of Science ®Google Scholar
• Hruby, A., J. E. Manson, L. Qi, V. S. Malik, E. B. Rimm, Q. Sun, W. C. Willett, and F. B. Hu. 2016. Determinants and consequences of obesity. American Journal of Public Health 106 (9):1656–62. doi: 10.2105/AJPH.2016.303326.
   PubMed Web of Science ®Google Scholar
• Hsu, C. L., and G. C. Yen. 2007. Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells. Journal of Agricultural and Food Chemistry 55 (5):1730–6. doi: 10.1021/jf062912b.
   PubMed Web of Science ®Google Scholar
• Hu, Y., E. A. Ehli, J. Kittelsrud, P. J. Ronan, K. Munger, T. Downey, K. Bohlen, L. Callahan, V. Munson, M. Jahnke, et al. 2012. Lipid-lowering effect of berberine in human subjects and rats. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 19 (10):861–7. doi: 10.1016/j.phymed.2012.05.009.
   PubMed Web of Science ®Google Scholar
• Huang, Y., X. Zhu, K. Chen, H. Lang, Y. Zhang, P. Hou, L. Ran, M. Zhou, J. Zheng, L. Yi, et al. 2019. Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway. Aging 11 (8):2217–40. doi: 10.18632/aging.101910.
   PubMedGoogle Scholar
• Ilavenil, S., M. V. Arasu, J. C. Lee, D. H. Kim, S. G. Roh, H. S. Park, G. J. Choi, V. Mayakrishnan, and K. C. Choi. 2014. Trigonelline attenuates the adipocyte differentiation and lipid accumulation in 3T3-L1 cells. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 21 (5):758–65. doi: 10.1016/j.phymed.2013.11.007.
   PubMed Web of Science ®Google Scholar
• Imamura, H., D. Nagayama, N. Ishihara, S. Tanaka, R. Watanabe, Y. Watanabe, Y. Sato, T. Yamaguchi, N. Ban, H. Kawana, et al. 2017. Resveratrol attenuates triglyceride accumulation associated with upregulation of Sirt1 and lipoprotein lipase in 3T3-L1 adipocytes. Molecular Genetics and Metabolism Reports 12:44–50. doi: 10.1016/j.ymgmr.2017.05.003.
   PubMed Web of Science ®Google Scholar
• Imenshahidi, M., and H. Hosseinzadeh. 2019. Berberine and barberry (Berberis vulgaris): A clinical review. Phytotherapy Research: PTR 33 (3):504–23. doi: 10.1002/ptr.6252.
   PubMed Web of Science ®Google Scholar
• Imran, K. M., N. Rahman, D. Yoon, M. Jeon, B. T. Lee, and Y. S. Kim. 2017. Cryptotanshinone promotes commitment to the brown adipocyte lineage and mitochondrial biogenesis in C3H10T1/2 mesenchymal stem cells via AMPK and p38-MAPK signaling. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids 1862 (10 Pt A):1110–20. doi: 10.1016/j.bbalip.2017.08.001.
   PubMed Web of Science ®Google Scholar
• Inoue, M., H. Tanabe, A. Matsumoto, M. Takagi, K. Umegaki, S. Amagaya, and J. Takahashi. 2012. Astaxanthin functions differently as a selective peroxisome proliferator-activated receptor γ modulator in adipocytes and macrophages. Biochemical Pharmacology 84 (5):692–700. doi: 10.1016/j.bcp.2012.05.021.
   PubMed Web of Science ®Google Scholar
• Jaacks, L. M., S. Vandevijvere, A. Pan, C. J. McGowan, C. Wallace, F. Imamura, D. Mozaffarian, B. Swinburn, and M. Ezzati. 2019. The obesity transition: Stages of the global epidemic. The Lancet. Diabetes & Endocrinology 7 (3):231–40. doi: 10.1016/S2213-8587(19)30026-9.
   PubMed Web of Science ®Google Scholar
• Jamar, G., D. Estadella, and L. P. Pisani. 2017. Contribution of anthocyanin-rich foods in obesity control through gut microbiota interactions. BioFactors (Oxford, England) 43 (4):507–16. doi: 10.1002/biof.1365.
   PubMed Web of Science ®Google Scholar
• Jang, H. J., S. D. Ridgeway, and J. A. Kim. 2013. Effects of the green tea polyphenol epigallocatechin-3-gallate on high-fat diet-induced insulin resistance and endothelial dysfunction. American Journal of Physiology. Endocrinology and Metabolism 305 (12):E1444–51. doi: 10.1152/ajpendo.00434.2013.
   PubMed Web of Science ®Google Scholar
• Jang, J., Y. Jung, S. J. Seo, S. M. Kim, Y. J. Shim, S. H. Cho, S. I. Chung, and Y. Yoon. 2017. Berberine activates AMPK to suppress proteolytic processing, nuclear translocation and target DNA binding of SREBP-1c in 3T3-L1 adipocytes. Molecular Medicine Reports 15 (6):4139–47. doi: 10.3892/mmr.2017.6513.
   PubMed Web of Science ®Google Scholar
• Jiang, D., D. Wang, X. Zhuang, Z. Wang, Y. Ni, S. Chen, and F. Sun. 2016. Berberine increases adipose triglyceride lipase in 3T3-L1 adipocytes through the AMPK pathway. Lipids in Health and Disease 15 (1):214. doi: 10.1186/s12944-016-0383-4.
   PubMedGoogle Scholar
• Jimenez-Gomez, Y., J. A. Mattison, K. J. Pearson, A. Martin-Montalvo, H. H. Palacios, A. M. Sossong, T. M. Ward, C. M. Younts, K. Lewis, J. S. Allard, et al. 2013. Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metabolism 18 (4):533–45. doi: 10.1016/j.cmet.2013.09.004.
   PubMed Web of Science ®Google Scholar
• Jin, T., Z. Song, J. Weng, and I. G. Fantus. 2018. Curcumin and other dietary polyphenols: Potential mechanisms of metabolic actions and therapy for diabetes and obesity. American Journal of Physiology. Endocrinology and Metabolism 314 (3):E201–5. doi: 10.1152/ajpendo.00285.2017.
   PubMed Web of Science ®Google Scholar
• Jung, U. J., Y. Y. Cho, and M. S. Choi. 2016. Apigenin ameliorates dyslipidemia, hepatic steatosis and insulin resistance by modulating metabolic and transcriptional profiles in the liver of high-fat diet-induced obese mice. Nutrients 8 (5): 305. doi: 10.3390/nu8050305.
   PubMed Web of Science ®Google Scholar
• Kang, J. H., C. S. Kim, I. S. Han, T. Kawada, and R. Yu. 2007. Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages. FEBS Letters 581 (23):4389–96. doi: 10.1016/j.febslet.2007.07.082.
   PubMed Web of Science ®Google Scholar
• Kang, Q., W. X. Song, Q. Luo, N. Tang, J. Y. Luo, X. J. Luo, J. Chen, Y. Bi, B. C. He, J. K. Park, et al. 2009. A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells and Development 18 (4):545–59. doi: 10.1089/scd.2008.0130.
   PubMed Web of Science ®Google Scholar
• Khan, M. I., J. H. Shin, T. S. Shin, M. Y. Kim, N. J. Cho, and J. D. Kim. 2018. Anthocyanins from Cornus kousa ethanolic extract attenuate obesity in association with anti-angiogenic activities in 3T3-L1 cells by down-regulating adipogeneses and lipogenesis. PLoS One 13 (12):e0208556. doi: 10.1371/journal.pone.0208556.
   PubMed Web of Science ®Google Scholar
• Kim, E. J., S. N. Jung, K. H. Son, S. R. Kim, T. Y. Ha, M. G. Park, I. G. Jo, J. G. Park, W. Choe, S. S. Kim, et al. 2007. Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase. Molecular Pharmacology 72 (1):62–72. doi: 10.1124/mol.107.034447.
   PubMed Web of Science ®Google Scholar
• Kim, M. A., K. Kang, H. J. Lee, M. Kim, C. Y. Kim, and C. W. Nho. 2014. Apigenin isolated from Daphne genkwa Siebold et Zucc. inhibits 3T3-L1 preadipocyte differentiation through a modulation of mitotic clonal expansion. Life Sciences 101 (1–2):64–72. doi: 10.1016/j.lfs.2014.02.012.
   PubMed Web of Science ®Google Scholar
• Kim, M. H., J. S. Park, M. S. Seo, J. W. Jung, Y. S. Lee, and K. S. Kang. 2010. Genistein and daidzein repress adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via Wnt/β-catenin signalling or lipolysis. Cell Proliferation 43 (6):594–605. doi: 10.1111/j.1365-2184.2010.00709.x.
   PubMed Web of Science ®Google Scholar
• Knab, A. M., R. A. Shanely, F. X. Jin, M. D. Austin, W. Sha, and D. C. Nieman. 2011. Quercetin with vitamin C and niacin does not affect body mass or composition. Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition et Metabolisme 36 (3):331–8. doi: 10.1139/H11-015.
   PubMed Web of Science ®Google Scholar
• Lagouge, M., C. Argmann, Z. Gerhart-Hines, H. Meziane, C. Lerin, F. Daussin, N. Messadeq, J. Milne, P. Lambert, P. Elliott, et al. 2006. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127 (6):1109–22. doi: 10.1016/j.cell.2006.11.013.
   PubMed Web of Science ®Google Scholar
• Lee, B., M. Kwon, J. S. Choi, H. O. Jeong, H. Y. Chung, and H. R. Kim. 2015. Kaempferol isolated from nelumbo nucifera inhibits lipid accumulation and increases fatty acid oxidation signaling in adipocytes. Journal of Medicinal Food 18 (12):1363–70. doi: 10.1089/jmf.2015.3457.
   PubMed Web of Science ®Google Scholar
• Lee, J. E., H. Schmidt, B. Lai, and K. Ge. 2019. Transcriptional and epigenomic regulation of adipogenesis. Molecular and Cellular Biology 39 (11):e00601-18. doi: 10.1128/MCB.00601-18.
   PubMed Web of Science ®Google Scholar
• Lee, J. S., Y. J. Cha, K. H. Lee, and J. E. Yim. 2016. Onion peel extract reduces the percentage of body fat in overweight and obese subjects: A 12-week, randomized, double-blind, placebo-controlled study. Nutrition Research and Practice 10 (2):175–81. doi: 10.4162/nrp.2016.10.2.175.
   PubMed Web of Science ®Google Scholar
• Lee, S., K. I. Keirsey, R. Kirkland, Z. I. Grunewald, J. G. Fischer, and C. B. de La Serre. 2018. Blueberry supplementation influences the gut microbiota, inflammation, and insulin resistance in high-fat-diet-fed rats. The Journal of Nutrition 148 (2):209–19. doi: 10.1093/jn/nxx027.
   PubMed Web of Science ®Google Scholar
• Leiherer, A., K. Stoemmer, A. Muendlein, C. H. Saely, E. Kinz, E. M. Brandtner, P. Fraunberger, and H. Drexel. 2016. Quercetin impacts expression of metabolism- and obesity-associated genes in SGBS adipocytes. Nutrients 8 (5):282. doi: 10.3390/nu8050282.
   Web of Science ®Google Scholar
• Leng, E., Y. Xiao, Z. Mo, Y. Li, Y. Zhang, X. Deng, M. Zhou, C. Zhou, Z. He, J. He, et al. 2018. Synergistic effect of phytochemicals on cholesterol metabolism and lipid accumulation in HepG2 cells. BMC Complementary and Alternative Medicine 18 (1):122. doi: 10.1186/s12906-018-2189-6.
   PubMedGoogle Scholar
• Li, F., C. Gao, P. Yan, M. Zhang, Y. H. Wang, Y. Hu, X. Y. Wu, X. J. Wang, and J. Sheng. 2018. EGCG reduces obesity and white adipose tissue gain partly through AMPK activation in mice. Frontiers in Pharmacology 9:1366. doi: 10.3389/fphar.2018.01366.
   PubMed Web of Science ®Google Scholar
• Li, L., Q. Dong, Y. F. Wang, Q. L. Feng, P. F. Zhou, X. Y. Ou, Q. R. Meng, T. C. He, and J. Y. Luo. 2015. Hedgehog signaling is involved in the BMP9-induced osteogenic differentiation of mesenchymal stem cells. International Journal of Molecular Medicine 35 (6):1641–50. doi: 10.3892/ijmm.2015.2172.
   PubMed Web of Science ®Google Scholar
• Li, Y., Y. Liu, Y. Tian, Y. Guo, C. Xue, and J. Wang. 2020. Comparison of different molecular forms of astaxanthin in inhibiting lipogenesis and its mechanism. Current Pharmaceutical Biotechnology. doi: 10.2174/1389201021666200626162301.
   Google Scholar
• Liang, H., L. Xu, X. Zhao, K. Pan, Z. Yi, J. Bai, X. Qi, J. Xin, M. Li, K. Ouyang, et al. 2020. RNA-Seq analysis reveals the potential molecular mechanisms of daidzein on adipogenesis in subcutaneous adipose tissue of finishing Xianan beef cattle. Journal of Animal Physiology and Animal Nutrition 104 (1):1–11. doi: 10.1111/jpn.13218.
   PubMed Web of Science ®Google Scholar
• Liu, M. H., Liu, H. M. J. H. Xie, Q. Xu, C. Pan, J. J. Wang, X. Wu, Sanabil, M. Z. Zheng, and J. S. Liu. 2017. Anti-obesity effects of zeaxanthin on 3T3-L1 preadipocyte and high fat induced obese mice. Food & Function 8 (9):3327–38. doi: 10.1039/c7fo00486a.
   PubMed Web of Science ®Google Scholar
• Liu, X., H. Zhao, Q. Jin, W. You, H. Cheng, Y. Liu, E. Song, G. Liu, X. Tan, X. Zhang, et al. 2018. Resveratrol induces apoptosis and inhibits adipogenesis by stimulating the SIRT1-AMPKα-FOXO1 signalling pathway in bovine intramuscular adipocytes. Molecular and Cellular Biochemistry 439 (1–2):213–23. doi: 10.1007/s11010-017-3149-z.
   PubMed Web of Science ®Google Scholar
• Lone, J., J. H. Choi, S. W. Kim, and J. W. Yun. 2016. Curcumin induces brown fat-like phenotype in 3T3-L1 and primary white adipocytes. The Journal of Nutritional Biochemistry 27:193–202. doi: 10.1016/j.jnutbio.2015.09.006.
   PubMed Web of Science ®Google Scholar
• Lorthongpanich, C., K. Thumanu, K. Tangkiettrakul, N. Jiamvoraphong, C. Laowtammathron, N. Damkham, Y. U-Pratya, and S. Issaragrisil. 2019. YAP as a key regulator of adipo-osteogenic differentiation in human MSCs. Stem Cell Research & Therapy 10 (1):402. doi: 10.1186/s13287-019-1494-4.
   PubMed Web of Science ®Google Scholar
• Luna-Vital, D., M. Weiss, and E. Gonzalez de Mejia. 2017. Anthocyanins from purple corn ameliorated tumor necrosis factor-alpha-induced inflammation and insulin resistance in 3T3-L1 adipocytes via activation of insulin signaling and enhanced GLUT4 translocation. Molecular Nutrition & Food Research 61 (12). doi: 10.1002/mnfr.201700362.
   PubMedGoogle Scholar
• Mahmmoud, Y. A. 2008. Capsaicin stimulates uncoupled ATP hydrolysis by the sarcoplasmic reticulum calcium pump. The Journal of Biological Chemistry 283 (31):21418–26. doi: 10.1074/jbc.M803654200.
   PubMed Web of Science ®Google Scholar
• Mahmmoud, Y. A., and M. Gaster. 2012. Uncoupling of sarcoplasmic reticulum Ca2+-ATPase by N-arachidonoyl dopamine. Members of the endocannabinoid family as thermogenic drugs. British Journal of Pharmacology 166 (7):2060–9. doi: 10.1111/j.1476-5381.2012.01899.x.
   PubMed Web of Science ®Google Scholar
• Maithilikarpagaselvi, N., M. G. Sridhar, R. P. Swaminathan, R. Sripradha, and B. Badhe. 2016. Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats. Pharmaceutical Biology 54 (12):2857–63. doi: 10.1080/13880209.2016.1187179.
   PubMed Web of Science ®Google Scholar
• Maurya, S. K., J. L. Herrera, S. K. Sahoo, F. C. G. Reis, R. B. Vega, D. P. Kelly, and M. Periasamy. 2018. Sarcolipin signaling promotes mitochondrial biogenesis and oxidative metabolism in skeletal muscle. Cell Reports 24 (11):2919–31. doi: 10.1016/j.celrep.2018.08.036.
   PubMed Web of Science ®Google Scholar
• Mendez-del Villar, M., M. Gonzalez-Ortiz, E. Martinez-Abundis, K. G. Perez-Rubio, and R. Lizarraga-Valdez. 2014. Effect of resveratrol administration on metabolic syndrome, insulin sensitivity, and insulin secretion. Metabolic Syndrome and Related Disorders 12 (10):497–501. doi: 10.1089/met.2014.0082.
   PubMed Web of Science ®Google Scholar
• Mi, J., W. He, J. Lv, K. Zhuang, H. Huang, and S. Quan. 2019. Effect of berberine on the HPA-axis pathway and skeletal muscle GLUT4 in type 2 diabetes mellitus rats. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 12:1717–25. doi: 10.2147/DMSO.S211188.
   PubMed Web of Science ®Google Scholar
• Mi, Y., X. Liu, H. Tian, H. Liu, J. Li, G. Qi, and X. Liu. 2018. EGCG stimulates the recruitment of brite adipocytes, suppresses adipogenesis and counteracts TNF-α-triggered insulin resistance in adipocytes. Food & Function 9 (6):3374–86. doi: 10.1039/c8fo00167g.
   PubMed Web of Science ®Google Scholar
• Moon, H. S., C. S. Chung, H. G. Lee, T. G. Kim, Y. J. Choi, and C. S. Cho. 2007. Inhibitory effect of (-)-epigallocatechin-3-gallate on lipid accumulation of 3T3-L1 cells. Obesity (Silver Spring, MD) 15 (11):2571–82. doi: 10.1038/oby.2007.309.
   PubMed Web of Science ®Google Scholar
• Mun, J. M., H. M. Ok, and O. Kwon. 2014. Corn gluten hydrolysate and capsaicin have complimentary actions on body weight reduction and lipid-related genes in diet-induced obese rats. Nutrition Research (New York, N.Y.) 34 (5):458–65. doi: 10.1016/j.nutres.2014.04.009.
   PubMed Web of Science ®Google Scholar
• Nettore, I. C., C. Rocca, G. Mancino, L. Albano, D. Amelio, F. Grande, F. Puoci, T. Pasqua, S. Desiderio, R. Mazza, et al. 2019. Quercetin and its derivative Q2 modulate chromatin dynamics in adipogenesis and Q2 prevents obesity and metabolic disorders in rats. The Journal of Nutritional Biochemistry 69:151–62. doi: 10.1016/j.jnutbio.2019.03.019.
   PubMed Web of Science ®Google Scholar
• Ono, M., and K. Fujimori. 2011. Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells. Journal of Agricultural and Food Chemistry 59 (24):13346–52. doi: 10.1021/jf203490a.
   PubMed Web of Science ®Google Scholar
• Pan, M. H., G. Yang, S. Li, M. Y. Li, M. L. Tsai, J. C. Wu, V. Badmaev, C. T. Ho, and C. S. Lai. 2017. Combination of citrus polymethoxyflavones, green tea polyphenols, and Lychee extracts suppresses obesity and hepatic steatosis in high-fat diet induced obese mice. Molecular Nutrition & Food Research 61 (11). doi: 10.1002/mnfr.201601104.
   Google Scholar
• Paraiso, A. F., J. N. Sousa, J. M. O. Andrade, E. S. Mangabeira, D. F. Lelis, A. M. B. de Paula, A. Martins, W. J. N. Lima, A. L. S. Guimaraes, G. A. Melo, et al. 2019. Oral gallic acid improves metabolic profile by modulating SIRT1 expression in obese mice brown adipose tissue: A molecular and bioinformatic approach. Life Sciences 237:116914. doi: 10.1016/j.lfs.2019.116914.
   PubMed Web of Science ®Google Scholar
• Park, H. J., J. Y. Yang, S. Ambati, M. A. Della-Fera, D. B. Hausman, S. Rayalam, and C. A. Baile. 2008. Combined effects of genistein, quercetin, and resveratrol in human and 3T3-L1 adipocytes. Journal of Medicinal Food 11 (4):773–83. doi: 10.1089/jmf.2008.0077.
   PubMed Web of Science ®Google Scholar
• Periasamy, M., J. L. Herrera, and F. C. G. Reis. 2017. Skeletal muscle thermogenesis and its role in whole body energy metabolism. Diabetes & Metabolism Journal 41 (5):327–36. doi: 10.4093/dmj.2017.41.5.327.
   PubMed Web of Science ®Google Scholar
• Periasamy, M., S. K. Maurya, S. K. Sahoo, S. Singh, S. K. Sahoo, F. C. G. Reis, and N. C. Bal. 2017. Role of SERCA pump in muscle thermogenesis and metabolism. Comprehensive Physiology 7 (3):879–90. doi: 10.1002/cphy.c160030.
   PubMed Web of Science ®Google Scholar
• Rahman, N., M. Jeon, H. Y. Song, and Y. S. Kim. 2016. Cryptotanshinone, a compound of Salvia miltiorrhiza inhibits pre-adipocytes differentiation by regulation of adipogenesis-related genes expression via STAT3 signaling. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 23 (1):58–67. doi: 10.1016/j.phymed.2015.12.004.
   PubMed Web of Science ®Google Scholar
• Rajakumari, S., J. Wu, J. Ishibashi, H. W. Lim, A. H. Giang, K. J. Won, R. R. Reed, and P. Seale. 2013. EBF2 determines and maintains brown adipocyte identity. Cell Metabolism 17 (4):562–74. doi: 10.1016/j.cmet.2013.01.015.
   PubMed Web of Science ®Google Scholar
• Rosen, E. D., and B. M. Spiegelman. 2014. What we talk about when we talk about fat. Cell 156 (1–2):20–44. doi: 10.1016/j.cell.2013.12.012.
   PubMed Web of Science ®Google Scholar
• Rowland, L. A., N. C. Bal, and M. Periasamy. 2015. The role of skeletal-muscle-based thermogenic mechanisms in vertebrate endothermy. Biological Reviews of the Cambridge Philosophical Society 90 (4):1279–97. doi: 10.1111/brv.12157.
   PubMed Web of Science ®Google Scholar
• Rui, L. 2017. Brown and Beige adipose tissues in health and disease. Comprehensive Physiology 7 (4):1281–306. doi: 10.1002/cphy.c170001.
   PubMed Web of Science ®Google Scholar
• Rustenbeck, I., V. Lier-Glaubitz, M. Willenborg, F. Eggert, U. Engelhardt, and A. Jorns. 2014. Effect of chronic coffee consumption on weight gain and glycaemia in a mouse model of obesity and type 2 diabetes. Nutrition & Diabetes 4 (6):e123. doi: 10.1038/nutd.2014.19.
   PubMedGoogle Scholar
• Santos, R. M., and D. R. Lima. 2016. Coffee consumption, obesity and type 2 diabetes: A mini-review. European Journal of Nutrition 55 (4):1345–58. doi: 10.1007/s00394-016-1206-0.
   PubMed Web of Science ®Google Scholar
• Saponaro, C., M. Gaggini, F. Carli, and A. Gastaldelli. 2015. The subtle balance between lipolysis and lipogenesis: A critical point in metabolic homeostasis. Nutrients 7 (11):9453–74. doi: 10.3390/nu7115475.
   PubMed Web of Science ®Google Scholar
• Seale, P. 2015. Transcriptional regulatory circuits controlling brown fat development and activation. Diabetes 64 (7):2369–75. doi: 10.2337/db15-0203.
   PubMed Web of Science ®Google Scholar
• Seale, P., S. Kajimura, W. Yang, S. Chin, L. M. Rohas, M. Uldry, G. Tavernier, D. Langin, and B. M. Spiegelman. 2007. Transcriptional control of brown fat determination by PRDM16. Cell Metabolism 6 (1):38–54. doi: 10.1016/j.cmet.2007.06.001.
   PubMed Web of Science ®Google Scholar
• Seo, M. J., Y. J. Lee, J. H. Hwang, K. J. Kim, and B. Y. Lee. 2015. The inhibitory effects of quercetin on obesity and obesity-induced inflammation by regulation of MAPK signaling. The Journal of Nutritional Biochemistry 26 (11):1308–16. doi: 10.1016/j.jnutbio.2015.06.005.
   PubMed Web of Science ®Google Scholar
• Seo, M. J., Y. J. Seo, C. H. Pan, O. H. Lee, K. J. Kim, and B. Y. Lee. 2016. Fucoxanthin suppresses lipid accumulation and ROS production during differentiation in 3T3-L1 adipocytes. Phytotherapy Research: PTR 30 (11):1802–8. doi: 10.1002/ptr.5683.
   PubMed Web of Science ®Google Scholar
• Seo, Y. S., O. H. Kang, S. B. Kim, S. H. Mun, D. H. Kang, D. W. Yang, J. G. Choi, Y. M. Lee, D. K. Kang, H. S. Lee, et al. 2015. Quercetin prevents adipogenesis by regulation of transcriptional factors and lipases in OP9 cells. International Journal of Molecular Medicine 35 (6):1779–85. doi: 10.3892/ijmm.2015.2185.
   PubMed Web of Science ®Google Scholar
• Setayesh, T., A. Nersesyan, M. Misik, R. Noorizadeh, E. Haslinger, T. Javaheri, E. Lang, M. Grusch, W. Huber, A. Haslberger, et al. 2019. Gallic acid, a common dietary phenolic protects against high fat diet induced DNA damage. European Journal of Nutrition 58 (6):2315–26. doi: 10.1007/s00394-018-1782-2.
   PubMed Web of Science ®Google Scholar
• Shang, A., R. Y. Gan, X. Y. Xu, Q. Q. Mao, P. Z. Zhang, and H. B. Li. 2020. Effects and mechanisms of edible and medicinal plants on obesity: An updated review. Critical Reviews in Food Science and Nutrition. doi: 10.1080/10408398.2020.1769548.
   Web of Science ®Google Scholar
• Shao, M. L., J. Ishibashi, C. M. Kusminski, Q. A. Wang, C. Hepler, L. Vishvanath, K. A. MacPherson, S. B. Spurgin, K. Sun, W. L. Holland, et al. 2016. Zfp423 maintains white adipocyte identity through suppression of the Beige cell thermogenic gene program. Cell Metabolism 23 (6):1167–84. doi: 10.1016/j.cmet.2016.04.023.
   PubMed Web of Science ®Google Scholar
• Shen, W., M. Y. Shen, X. Zhao, H. B. Zhu, Y. H. Yang, S. G. Lu, Y. L. Tan, G. Li, M. Li, J. Wang, et al. 2017. Anti-obesity effect of capsaicin in mice fed with high-fat diet is associated with an increase in population of the gut bacterium Akkermansia muciniphila. Frontiers in Microbiology 8:1–10. doi: 10.3389/fmicb.2017.00272.
   PubMed Web of Science ®Google Scholar
• Song, Z., X. Revelo, W. Shao, L. Tian, K. Zeng, H. Lei, H. S. Sun, M. Woo, D. Winer, and T. Jin. 2018. Dietary curcumin intervention targets mouse white adipose tissue inflammation and brown adipose tissue UCP1 expression. Obesity (Silver Spring, MD) 26 (3):547–58. doi: 10.1002/oby.22110.
   PubMed Web of Science ®Google Scholar
• Sousa, J. N., A. F. Paraiso, J. M. O. Andrade, D. F. Lelis, E. M. Santos, J. P. Lima, R. S. Monteiro-Junior, M. D'Angelo, A. M. B. de Paula, A. L. S. Guimaraes, et al. 2020. Oral gallic acid improve liver steatosis and metabolism modulating hepatic lipogenic markers in obese mice. Experimental Gerontology 134:110881. doi: 10.1016/j.exger.2020.110881.
   PubMed Web of Science ®Google Scholar
• Steensels, S., and B. A. Ersoy. 2019. Fatty acid activation in thermogenic adipose tissue. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1864 (1):79–90. doi: 10.1016/j.bbalip.2018.05.008.
   PubMed Web of Science ®Google Scholar
• Sturla, L., E. Mannino, S. Scarfi, S. Bruzzone, M. Magnone, G. Sociali, V. Booz, L. Guida, T. Vigliarolo, C. Fresia, et al. 2017. Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1862 (2):131–44. doi: 10.1016/j.bbalip.2016.11.005.
   PubMed Web of Science ®Google Scholar
• Su, T., C. H. Huang, C. F. Yang, T. Jiang, J. F. Su, M. T. Chen, S. Fatima, R. H. Gong, X. J. Hu, Z. X. Bian, et al. 2020. Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity. Pharmacological Research 152:104586. doi: 10.1016/j.phrs.2019.104586.
   PubMed Web of Science ®Google Scholar
• Szkudelska, K., L. Nogowski, and T. Szkudelski. 2009. Resveratrol, a naturally occurring diphenolic compound, affects lipogenesis, lipolysis and the antilipolytic action of insulin in isolated rat adipocytes. The Journal of Steroid Biochemistry and Molecular Biology 113 (1–2):17–24. doi: 10.1016/j.jsbmb.2008.11.001.
   PubMed Web of Science ®Google Scholar
• Tang, W., and Y. Y. Fan. 2019. SIRT6 as a potential target for treating insulin resistance. Life Sciences 231:116558. doi: 10.1016/j.lfs.2019.116558.
   PubMed Web of Science ®Google Scholar
• Timmers, S., E. Konings, L. Bilet, R. H. Houtkooper, T. van de Weijer, G. H. Goossens, J. Hoeks, S. van der Krieken, D. Ryu, S. Kersten, et al. 2011. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metabolism 14 (5):612–22. doi: 10.1016/j.cmet.2011.10.002.
   PubMed Web of Science ®Google Scholar
• Torres-Villarreal, D., A. Camacho, H. Castro, R. Ortiz-Lopez, and A. L. de la Garza. 2019. Anti-obesity effects of kaempferol by inhibiting adipogenesis and increasing lipolysis in 3T3-L1 cells. Journal of Physiology and Biochemistry 75 (1):83–8. doi: 10.1007/s13105-018-0659-4.
   PubMed Web of Science ®Google Scholar
• Unno, T., M. Sakuma, and S. Mitsuhashi. 2014. Effect of dietary supplementation of (-)-epigallocatechin gallate on gut microbiota and biomarkers of colonic fermentation in rats. Journal of Nutritional Science and Vitaminology 60 (3):213–9. doi: 10.3177/jnsv.60.213.
   PubMed Web of Science ®Google Scholar
• Varshney, R., R. Varshney, R. Mishra, S. Gupta, D. Sircar, and P. Roy. 2018. Kaempferol alleviates palmitic acid-induced lipid stores, endoplasmic reticulum stress and pancreatic β-cell dysfunction through AMPK/mTOR-mediated lipophagy. The Journal of Nutritional Biochemistry 57:212–27. doi: 10.1016/j.jnutbio.2018.02.017.
   PubMed Web of Science ®Google Scholar
• Wang, B., Q. Yang, C. L. Harris, M. L. Nelson, J. R. Busboom, M. J. Zhu, and M. Du. 2016. Nutrigenomic regulation of adipose tissue development - role of retinoic acid: A review. Meat Science 120:100–6. doi: 10.1016/j.meatsci.2016.04.003.
   PubMed Web of Science ®Google Scholar
• Wang, H., X. Mao, and M. Du. 2019. Phytanic acid activates PPARα to promote beige adipogenic differentiation of preadipocytes. The Journal of Nutritional Biochemistry 67:201–11. doi: 10.1016/j.jnutbio.2019.02.013.
   PubMed Web of Science ®Google Scholar
• Wang, J., S. Liu, H. Wang, S. Xiao, C. Li, Y. Li, and B. Liu. 2019. Xanthophyllomyces dendrorhous-derived astaxanthin regulates lipid metabolism and gut microbiota in obese mice induced by a high-fat diet. Marine Drugs 17 (6):337. doi: 10.3390/md17060337.
   PubMed Web of Science ®Google Scholar
• Wang, L., B. Zhang, F. Huang, B. Liu, and Y. Xie. 2016. Curcumin inhibits lipolysis via suppression of ER stress in adipose tissue and prevents hepatic insulin resistance. Journal of Lipid Research 57 (7):1243–55. doi: 10.1194/jlr.M067397.
   PubMedGoogle Scholar
• Wang, L. J., X. Ye, Y. Y. Hua, and Y. X. Song. 2018. Berberine alleviates adipose tissue fibrosis by inducing AMP-activated kinase signaling in high-fat diet-induced obese mice. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 105:121–9. doi: 10.1016/j.biopha.2018.05.110.
   PubMed Web of Science ®Google Scholar
• Wang, S., X. Liang, Q. Yang, X. Fu, C. J. Rogers, M. Zhu, B. Rodgers, Q. Jiang, M. V. Dodson, and M. Du. 2015. Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1. International Journal of Obesity (2005) 39 (6):967–76. doi: 10.1038/ijo.2015.23.
   PubMed Web of Science ®Google Scholar
• Wang, S. B., X. W. Liang, Q. Y. Yang, X. Fu, M. J. Zhu, B. D. Rodgers, Q. Y. Jiang, M. V. Dodson, and M. Du. 2017. Resveratrol enhances brown adipocyte formation and function by activating AMP-activated protein kinase (AMPK) alpha 1 in mice fed high-fat diet. Molecular Nutrition & Food Research 61 (4). doi: 10.1002/mnfr.201600746.
   Google Scholar
• Wang, T. Q., Q. M. Wu, and T. Q. Zhao. 2020. Preventive effects of kaempferol on high-fat diet-induced obesity complications in C57BL/6 mice. Biomed Research International. doi: 10.1155/2020/4532482.
   Google Scholar
• Wang, Y. W., C. Tang, Y. Tang, H. Y. Yin, and X. Liu. 2020. Capsaicin has an anti-obesity effect through alterations in gut microbiota populations and short-chain fatty acid concentrations. Food & Nutrition Research 64. doi: 10.29219/fnr.v64.3525.
   Web of Science ®Google Scholar
• Wolfram, S., Y. Wang, and F. Thielecke. 2006. Anti-obesity effects of green tea: From bedside to bench. Molecular Nutrition & Food Research 50 (2):176–87. doi: 10.1002/mnfr.200500102.
   PubMed Web of Science ®Google Scholar
• Wu, L. Y., C. W. Chen, L. K. Chen, H. Y. Chou, C. L. Chang, and C. C. Juan. 2019. Curcumin attenuates adipogenesis by inducing preadipocyte apoptosis and inhibiting adipocyte differentiation. Nutrients 11 (10):2307. doi: 10.3390/nu11102307.
   PubMed Web of Science ®Google Scholar
• Wu, T., Y. Gao, X. Guo, M. Zhang, and L. Gong. 2018. Blackberry and blueberry anthocyanin supplementation counteract high-fat-diet-induced obesity by alleviating oxidative stress and inflammation and accelerating energy expenditure. Oxidative Medicine and Cellular Longevity 2018:4051232. doi: 10.1155/2018/4051232.
   PubMed Web of Science ®Google Scholar
• Wu, T., Z. Jiang, J. Yin, H. Long, and X. Zheng. 2016. Anti-obesity effects of artificial planting blueberry (Vaccinium ashei) anthocyanin in high-fat diet-treated mice. International Journal of Food Sciences and Nutrition 67 (3):257–64. doi: 10.3109/09637486.2016.1146235.
   PubMed Web of Science ®Google Scholar
• Wu, T., J. Yin, G. Zhang, H. Long, and X. Zheng. 2016. Mulberry and cherry anthocyanin consumption prevents oxidative stress and inflammation in diet-induced obese mice. Molecular Nutrition & Food Research 60 (3):687–94. doi: 10.1002/mnfr.201500734.
   PubMed Web of Science ®Google Scholar
• Xu, J. H., X. Z. Liu, W. Pan, and D. J. Zou. 2017. Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. Molecular Medicine Reports 15 (5):2765–87. doi: 10.3892/mmr.2017.6321.
   PubMed Web of Science ®Google Scholar
• Yang, Y. Q., F. L. Liu, R. S. Lu, and J. L. Jia. 2019. Berberine inhibits adipogenesis in porcine adipocytes via AMP-activated protein kinase-dependent and -independent mechanisms. Lipids 54 (11–12):667–78. doi: 10.1002/lipd.12200.
   PubMed Web of Science ®Google Scholar
• Yang, Y. Q., R. S. Lu, F. F. Gao, J. Zhang, and F. L. Liu. 2020. Berberine induces lipolysis in porcine adipocytes by activating the AMP‑activated protein kinase pathway. Molecular Medicine Reports 21 (6):2603–14. doi: 10.3892/mmr.2020.11070.
   PubMed Web of Science ®Google Scholar
• Yang, Z., M. Z. Zhu, Y. B. Zhang, B. B. Wen, H. M. An, X. C. Ou, Y. F. Xiong, H. Y. Lin, Z. H. Liu, and J. A. Huang. 2019. Coadministration of epigallocatechin-3-gallate (EGCG) and caffeine in low dose ameliorates obesity and nonalcoholic fatty liver disease in obese rats. Phytotherapy Research: PTR 33 (4):1019–26. doi: 10.1002/ptr.6295.
   PubMed Web of Science ®Google Scholar
• Yoshinari, O., H. Sato, and K. Igarashi. 2009. Anti-diabetic effects of pumpkin and its components, trigonelline and nicotinic acid, on Goto-Kakizaki rats. Bioscience, Biotechnology, and Biochemistry 73 (5):1033–41. doi: 10.1271/bbb.80805.
   PubMed Web of Science ®Google Scholar
• Zang, Y. Q., L. P. Zhang, K. Igarashi, and C. Q. Yu. 2015. The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice. Food & Function 6 (3):834–41. doi: 10.1039/c4fo00844h.
   PubMed Web of Science ®Google Scholar
• Zhang, G., Q. Sun, and C. Liu. 2016. Influencing factors of thermogenic adipose tissue activity. Frontiers in Physiology 7:29. doi: 10.3389/fphys.2016.00029.
   PubMed Web of Science ®Google Scholar
• Zhang, X., Y. F. Zhao, J. Xu, Z. S. Xue, M. H. Zhang, X. Y. Pang, X. J. Zhang, and L. P. Zhao. 2015. Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. Scientific Reports 5:14405. doi: 10.1038/srep14405.
   PubMed Web of Science ®Google Scholar
• Zhang, Z. G., H. Z. Zhang, B. Li, X. J. Meng, J. Q. Wang, Y. F. Zhang, S. S. Yao, Q. Y. Ma, L. N. Jin, J. Yang, et al. 2014. Berberine activates thermogenesis in white and brown adipose tissue. Nature Communications 5 (1):5493. doi: 10.1038/ncomms6493.
   PubMedGoogle Scholar
• Zhou, J., L. Mao, P. Xu, and Y. Wang. 2018. Effects of (-)-epigallocatechin gallate (EGCG) on energy expenditure and microglia-mediated hypothalamic inflammation in mice fed a high-fat diet. Nutrients 10 (11):1681. doi: 10.3390/nu10111681.
   Web of Science ®Google Scholar
• Zhu, X., J. Yang, W. Zhu, X. Yin, B. Yang, Y. Wei, and X. Guo. 2018. Combination of berberine with resveratrol improves the lipid-lowering efficacy. International Journal of Molecular Sciences. 19 (12):3903. doi: 10.3390/ijms19123903.
   Web of Science ®Google Scholar