The colorful world of carotenoids: a profound insight on therapeutics and recent trends in nano delivery systems

References

• Aboalnaja, K. O., S. Yaghmoor, T. A. Kumosani, and D. J. McClements. 2016. Utilization of nanoemulsions to enhance bioactivity of pharmaceuticals, supplements, and nutraceuticals: Nanoemulsion delivery systems and nanoemulsion excipient systems. Expert Opinion on Drug Delivery 13 (9):1327–36. doi: 10.1517/17425247.2016.1162154.
   PubMed Web of Science ®Google Scholar
• Acosta, E. 2009. Bioavailability of nanoparticles in nutrient and nutraceutical delivery. Current Opinion in Colloid & Interface Science 14 (1):3–15. doi: 10.1016/j.cocis.2008.01.002.
   Web of Science ®Google Scholar
• Akbari, S., and R. M. Kozłowski. 2019. A review of application of amine-terminated dendritic materials in textile engineering. The Journal of the Textile Institute 110 (3):460–7. doi: 10.1080/00405000.2018.1512361.
   Web of Science ®Google Scholar
• Akhavan, S., E. Assadpour, I. Katouzian, and S. M. Jafari. 2018. Lipid nano scale cargos for the protection and delivery of food bioactive ingredients and nutraceuticals. Trends in Food Science & Technology 74:132–46. doi: 10.1016/j.tifs.2018.02.001.
   Web of Science ®Google Scholar
• Alam, M. N., M. M. Hossain, M. M. Rahman, N. Subhan, M. A. A. Mamun, A. Ulla, H. M. Reza, and M. A. Alam. 2018. Astaxanthin prevented oxidative stress in heart and kidneys of isoproterenol-administered aged rats. Journal of Dietary Supplements 15 (1):42–54. doi: 10.1080/19390211.2017.1321078.
   PubMedGoogle Scholar
• Alvarez, R., B. Vaz, H. Gronemeyer, and A. R. de Lera. 2014. Functions, therapeutic applications, and synthesis of retinoids and carotenoids. Chemical Reviews 114 (1):1–125. doi: 10.1021/cr400126u.
   PubMed Web of Science ®Google Scholar
• Ambati, R. R., D. Gogisetty, R. G. Aswathanarayana, S. Ravi, P. N. Bikkina, L. Bo, and S. Yuepeng. 2019. Industrial potential of carotenoid pigments from microalgae: Current trends and future prospects. Critical Reviews in Food Science and Nutrition 59 (12):1880–902. doi: 10.1080/10408398.2018.1432561.
   PubMed Web of Science ®Google Scholar
• Ansari, M. and N. Gupta. 2004. Lycopene: A novel drug therapy in hormone refractory metastatic prostate cancer. Urologic Oncology: Seminars and Original Investigations 22 (5):415–20. doi: 10.1016/S1078-1439(04)00122-X.
   PubMed Web of Science ®Google Scholar
• Applegate, C. C., J. L. Rowles, and J. W. Erdman. 2019. Can lycopene impact the androgen axis in prostate cancer?: A systematic review of cell culture and animal studies. Nutrients 11 (3):633. doi: 10.3390/nu11030633.
   PubMed Web of Science ®Google Scholar
• Arathi, B. P., P. Raghavendra-Rao Sowmya, G. C. Kuriakose, S. Shilpa, H. J. Shwetha, S. Kumar, M. Raju, V. Baskaran, and R. Lakshminarayana. 2018. Fractionation and characterization of lycopene-oxidation products by LC-MS/MS (ESI)+: Elucidation of the chemopreventative potency of oxidized lycopene in breast-cancer cell lines. Journal of Agricultural and Food Chemistry 66 (43):11362–71. doi: 10.1021/acs.jafc.8b04850.
   PubMed Web of Science ®Google Scholar
• Arunkumar, R., K. V. H. Prashanth, and V. Baskaran. 2013. Promising interaction between nanoencapsulated lutein with low molecular weight chitosan: Characterization and bioavailability of lutein in vitro and in vivo. Food Chemistry 141 (1):327–37. doi: 10.1016/j.foodchem.2013.02.108.
   PubMed Web of Science ®Google Scholar
• Assadpour, E., and S. M. Jafari. 2019. An overview of biopolymer nanostructures for encapsulation of food ingredients. In Biopolymer nanostructures for food encapsulation purposes, ed. S. M. Jafari, Vol. 1, 1–35. Elsevier.
   Google Scholar
• Assadpour, E., and S. Mahdi Jafari. 2019. A systematic review on nanoencapsulation of food bioactive ingredients and nutraceuticals by various nanocarriers. Critical Reviews in Food Science and Nutrition 59 (19):3129–51. doi: 10.1080/10408398.2018.1484687.
   PubMed Web of Science ®Google Scholar
• Babadi, F. E., P. Boonnoun, K. Nootong, S. Powtongsook, M. Goto, and A. Shotipruk. 2020. Identification of carotenoids and chlorophylls from green algae Chlorococcum humicola and extraction by liquefied dimethyl ether. Food and Bioproducts Processing 123:296–303. doi: 10.1016/j.fbp.2020.07.008.
   Web of Science ®Google Scholar
• Bai, S.-K., S.-J. Lee, H.-J. Na, K.-S. Ha, J.-A. Han, H. Lee, Y.-G. Kwon, C.-K. Chung, and Y.-M. Kim. 2005. beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation. Experimental & Molecular Medicine 37 (4):323–34. doi: 10.1038/emm.2005.42.
   PubMed Web of Science ®Google Scholar
• Balić, A., and M. Mokos. 2019. Do we utilize our knowledge of the skin protective effects of carotenoids enough? Antioxidants 8 (8):259. doi: 10.3390/antiox8080259.
   Web of Science ®Google Scholar
• Bansal, P., S. K. Gupta, S. K. Ojha, M. Nandave, R. Mittal, S. Kumari, and D. S. Arya. 2006. Cardioprotective effect of lycopene in the experimental model of myocardial ischemia-reperfusion injury. Molecular and Cellular Biochemistry 289 (1–2):1–9. doi: 10.1007/s11010-006-9141-7.
   PubMed Web of Science ®Google Scholar
• Barman, K., D. Chowdhury, and P. K. Baruah. 2020. Development of β‐carotene loaded nanoemulsion using the industrial waste of orange (Citrus reticulate) peel to improve in vitro bioaccessibility of carotenoids and use as natural food colorant. Journal of Food Processing and Preservation 44 (5):e14429. doi: 10.1111/jfpp.14429.
   Web of Science ®Google Scholar
• Barreiro, C., and J.-L. Barredo. 2018. Carotenoids production: A healthy and profitable industry. Microbial Carotenoids: Springer 45–55.
   Google Scholar
• Bayraç, A. T., O. E. Akça, F. İ. Eyidoğan, and H. Öktem. 2018. Target-specific delivery of doxorubicin to human glioblastoma cell line via ssDNA aptamer. Journal of Biosciences 43 (1):97–104. doi: 10.1007/s12038-018-9733-x.
   PubMed Web of Science ®Google Scholar
• Becerra, M. O., L. M. Contreras, M. H. Lo, J. M. Díaz, and G. C. Herrera. 2020. Lutein as a functional food ingredient: Stability and bioavailability. Journal of Functional Foods 66 :103771.
   Web of Science ®Google Scholar
• Bechor, S., N. Zolberg Relevy, A. Harari, T. Almog, Y. Kamari, A. Ben-Amotz, D. Harats, and A. Shaish. 2016. 9-cis beta-carotene increased cholesterol efflux to HDL in macrophages. Nutrients 8 (7):435. doi: 10.3390/nu8070435.
   Web of Science ®Google Scholar
• Bera, S., and D. Dutta. 2017. Encapsulation and release of a bacterial carotenoid from hydrogel matrix: Characterization, kinetics and antioxidant study. Engineering in Life Sciences 17 (7):739–48. doi: 10.1002/elsc.201600238.
   PubMed Web of Science ®Google Scholar
• Bezerra, P. Q. M., M. F. R. d Matos, I. G. Ramos, K. T. Magalhães-Guedes, J. I. Druzian, J. A. V. Costa, and I. L. Nunes. 2019. Innovative functional nanodispersion: Combination of carotenoid from Spirulina and yellow passion fruit albedo. Food Chemistry 285:397–405. doi: 10.1016/j.foodchem.2019.01.181.
   PubMed Web of Science ®Google Scholar
• Bhatt, P. C., P. Srivastava, P. Pandey, W. Khan, and B. P. Panda. 2016. Nose to brain delivery of astaxanthin-loaded solid lipid nanoparticles: Fabrication, radio labeling, optimization and biological studies. RSC Advances 6 (12):10001–10. doi: 10.1039/C5RA19113K.
   Web of Science ®Google Scholar
• Bohn, T., C. Desmarchelier, S. N. El, J. Keijer, E. van Schothorst, R. Rühl, and P. Borel. 2019. β-Carotene in the human body: Metabolic bioactivation pathways - from digestion to tissue distribution and excretion. The Proceedings of the Nutrition Society 78 (1):68–87. doi: 10.1017/S0029665118002641.
   PubMed Web of Science ®Google Scholar
• Brazionis, L., K. Rowley, C. Itsiopoulos, and K. O'Dea. 2009. Plasma carotenoids and diabetic retinopathy. The British Journal of Nutrition 101 (2):270–7. doi: 10.1017/S0007114508006545.
   PubMed Web of Science ®Google Scholar
• Britton, G. 1995. Structure and properties of carotenoids in relation to function. The Faseb Journal 9 (15):1551–8. doi: 10.1096/fasebj.9.15.8529834.
   PubMed Web of Science ®Google Scholar
• Brugè, F., E. Damiani, C. Puglia, A. Offerta, T. Armeni, G. P. Littarru, and L. Tiano. 2013. Nanostructured lipid carriers loaded with CoQ10: Effect on human dermal fibroblasts under normal and UVA-mediated oxidative conditions. International Journal of Pharmaceutics 455 (1–2):348–56. doi: 10.1016/j.ijpharm.2013.06.075.
   PubMed Web of Science ®Google Scholar
• Campos, P. M., J. P. Abriata, A. T. Ogunjimi, J. M. Marchetti, and R. Lee. 2018. Dendrimers: A tool for advanced drug delivery. In Dendrimers for drug delivery, ed. Anil K. Sharma and Raj K. Keservani, 49–96. New York: Apple Academic Press.
   Google Scholar
• Chaari, M., I. Theochari, V. Papadimitriou, A. Xenakis, and E. Ammar. 2018. Encapsulation of carotenoids extracted from halophilic Archaea in oil-in-water (O/W) micro- and nano-emulsions. Colloids and Surfaces B: Biointerfaces 161:219–27. doi: 10.1016/j.colsurfb.2017.10.042.
   PubMed Web of Science ®Google Scholar
• Chang, J., Y. Zhang, Y. Li, K. Lu, Y. Shen, Y. Guo, Q. Qi, M. Wang, and S. Zhang. 2018. NrF2/ARE and NF-κB pathway regulation may be the mechanism for lutein inhibition of human breast cancer cell. Future Oncology (London, England) 14 (8):719–26. doi: 10.2217/fon-2017-0584.
   PubMed Web of Science ®Google Scholar
• Chang, R., J. Yang, S. Ge, M. Zhao, C. Liang, L. Xiong, and Q. Sun. 2017. Synthesis and self-assembly of octenyl succinic anhydride modified short glucan chains based amphiphilic biopolymer: Micelles, ultrasmall micelles, vesicles, and lutein encapsulation/release. Food Hydrocolloids 67:14–26. doi: 10.1016/j.foodhyd.2016.12.023.
   Web of Science ®Google Scholar
• Chen, J., F. Li, Z. Li, D. J. McClements, and H. Xiao. 2017. Encapsulation of carotenoids in emulsion-based delivery systems: Enhancement of β-carotene water-dispersibility and chemical stability. Food Hydrocolloids 69:49–55. doi: 10.1016/j.foodhyd.2017.01.024.
   Web of Science ®Google Scholar
• Chen, J., Y. Song, and L. Zhang. 2013. Effect of lycopene supplementation on oxidative stress: An exploratory systematic review and meta-analysis of randomized controlled trials. Journal of Medicinal Food 16 (5):361–74. doi: 10.1089/jmf.2012.2682.
   PubMed Web of Science ®Google Scholar
• Chen, M. L., Y. H. Lin, C. M. Yang, and M. L. Hu. 2012. Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways. Molecular Nutrition & Food Research 56 (6):889–99. doi: 10.1002/mnfr.201100683.
   PubMed Web of Science ®Google Scholar
• Chen, Y.-T., C.-J. Kao, H.-Y. Huang, S.-Y. Huang, C.-Y. Chen, Y.-S. Lin, Z.-H. Wen, and H.-M D. Wang. 2017. Astaxanthin reduces MMP expressions, suppresses cancer cell migrations, and triggers apoptotic caspases of in vitro and in vivo models in melanoma. Journal of Functional Foods 31:20–31. doi: 10.1016/j.jff.2017.01.005.
   Web of Science ®Google Scholar
• Cheng, C. J., M. Ferruzzi, and O. G. Jones. 2019. Fate of lutein-containing zein nanoparticles following simulated gastric and intestinal digestion. Food Hydrocolloids 87:229–36. doi: 10.1016/j.foodhyd.2018.08.013.
   Web of Science ®Google Scholar
• Cheng, H. M., G. Koutsidis, J. K. Lodge, A. W. Ashor, M. Siervo, and J. Lara. 2019. Lycopene and tomato and risk of cardiovascular diseases: A systematic review and meta-analysis of epidemiological evidence. Critical Reviews in Food Science and Nutrition 59 (1):141–58. doi: 10.1080/10408398.2017.1362630.
   PubMed Web of Science ®Google Scholar
• Chintong, S., W. Phatvej, U. Rerk-Am, Y. Waiprib, and W. Klaypradit. 2019. In vitro antioxidant, antityrosinase, and cytotoxic activities of astaxanthin from shrimp waste. Antioxidants 8 (5):128. doi: 10.3390/antiox8050128.
   Web of Science ®Google Scholar
• Chuacharoen, T., and C. M. Sabliov. 2016. The potential of zein nanoparticles to protect entrapped β-carotene in the presence of milk under simulated gastrointestinal (GI) conditions. Lwt - Food Science and Technology 72:302–9. doi: 10.1016/j.lwt.2016.05.006.
   Web of Science ®Google Scholar
• Chuyen, H. V., P. D. Roach, J. B. Golding, S. E. Parks, and M. H. Nguyen. 2019. Encapsulation of carotenoid-rich oil from Gac peel: Optimisation of the encapsulating process using a spray drier and the storage stability of encapsulated powder. Powder Technology 344:373–9. doi: 10.1016/j.powtec.2018.12.012.
   Web of Science ®Google Scholar
• Cicero, A. F. G., and A. Colletti. 2017. Effects of carotenoids on health: Are all the same? Results from clinical trials. Current Pharmaceutical Design 23 (17):2422–7. doi: 10.2174/1381612823666170207095459.
   PubMed Web of Science ®Google Scholar
• Cooperstone, J. L., K. L. Tober, K. M. Riedl, M. D. Teegarden, M. J. Cichon, D. M. Francis, S. J. Schwartz, and T. M. Oberyszyn. 2017. Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations. Scientific Reports 7 (1):1–9. doi: 10.1038/s41598-017-05568-7.
   PubMedGoogle Scholar
• Costa-Rodrigues, J., O. Pinho, and PJFc Monteiro. 2018. Can lycopene be considered an effective protection against cardiovascular disease? Food Chemistry 245:1148–53. doi: 10.1016/j.foodchem.2017.11.055.
   PubMed Web of Science ®Google Scholar
• da Silva Santos, V., A. P. B. Ribeiro, and M. H. A. Santana. 2019. Solid lipid nanoparticles as carriers for lipophilic compounds for applications in foods. Food Research International (Ottawa, Ont.) 122:610–26. doi: 10.1016/j.foodres.2019.01.032.
   PubMed Web of Science ®Google Scholar
• Dadgostar, P. 2019. Antimicrobial resistance: Implications and costs. Infection and Drug Resistance 12:3903–10. doi: 10.2147/IDR.S234610.
   PubMed Web of Science ®Google Scholar
• Dasgupta, N., and S. Ranjan. 2018. Ingredients and components of nanoemulsions. In An introduction to food grade nanoemulsions. Environmental chemistry for a sustainable world, 63–82. Singapore: Springer.
   Google Scholar
• Dasgupta, N., S. Ranjan, and M. Gandhi. 2019. Nanoemulsion ingredients and components. Environmental Chemistry Letters 17 (2):917–28. doi: 10.1007/s10311-018-00849-7.
   Web of Science ®Google Scholar
• Davies, N. P., and A. B. Morland. 2002. Color matching in diabetes: Optical density of the crystalline lens and macular pigments. Investigative Ophthalmology & Visual Science 43 (1):281–9.
   PubMed Web of Science ®Google Scholar
• Davinelli, S., M. E. Nielsen, and G. Scapagnini. 2018. Astaxanthin in skin health, repair, and disease: A comprehensive review. Nutrients 10 (4):522. doi: 10.3390/nu10040522.
   PubMed Web of Science ®Google Scholar
• de Carvalho, S. M., C. M. Noronha, C. L. Floriani, R. C. Lino, G. Rocha, I. C. Bellettini, P. J. Ogliari, and P. L. M. Barreto. 2013. Optimization of α-tocopherol loaded solid lipid nanoparticles by central composite design. Industrial Crops and Products 49:278–85. doi: 10.1016/j.indcrop.2013.04.054.
   Web of Science ®Google Scholar
• de Oca-Ávalos, J. M. M., R. J. Candal, and M. L. Herrera. 2017. Nanoemulsions: Stability and physical properties. Current Opinion in Food Science 16:1–6. doi: 10.1016/j.cofs.2017.06.003.
   Web of Science ®Google Scholar
• Demirci, M., M. Y. Caglar, B. Cakir, and İ. Gülseren. 2017. Encapsulation by nanoliposomes. In Nanoencapsulation technologies for the food and nutraceutical industries, ed. S. M. Jafari, 74–113. New York: Elsevier.
   Google Scholar
• Devi, N., M. Sarmah, B. Khatun, and T. K. Maji. 2017. Encapsulation of active ingredients in polysaccharide-protein complex coacervates. Advances in Colloid and Interface Science 239:136–45. doi: 10.1016/j.cis.2016.05.009.
   PubMed Web of Science ®Google Scholar
• Di Tomo, P., R. Canali, D. Ciavardelli, S. Di Silvestre, A. De Marco, A. Giardinelli, C. Pipino, N. Di Pietro, F. Virgili, A. Pandolfi, et al. 2012. β-Carotene and lycopene affect endothelial response to TNF-α reducing nitro-oxidative stress and interaction with monocytes. Molecular Nutrition & Food Research 56 (2):217–27. doi: 10.1002/mnfr.201100500.
   PubMed Web of Science ®Google Scholar
• Dong, S., Y. Huang, R. Zhang, Z. Lian, S. Wang, and Y. Liu. 2014. Inclusion complexes of astaxanthin with hydroxypropyl‐β‐cyclodextrin: Parameters optimization, spectroscopic profiles, and properties. European Journal of Lipid Science and Technology 116 (8):978–86. doi: 10.1002/ejlt.201300261.
   Web of Science ®Google Scholar
• Dos Santos, R. C., A. S. Ombredane, J. M. T. Souza, A. G. Vasconcelos, A. Plácido, A. d G. N. Amorim, E. A. Barbosa, F. C. D. A. Lima, C. D. Ropke, M. M. M. Alves, et al. 2018. Lycopene-rich extract from red guava (Psidium guajava L.) displays cytotoxic effect against human breast adenocarcinoma cell line MCF-7 via an apoptotic-like pathway. Food Research International (Ottawa, Ont.) 105:184–96. doi: 10.1016/j.foodres.2017.10.045.
   PubMed Web of Science ®Google Scholar
• Du, Y., C. Bao, J. Huang, P. Jiang, L. Jiao, F. Ren, and Y. Li. 2019. Improved stability, epithelial permeability and cellular antioxidant activity of β-carotene via encapsulation by self-assembled α-lactalbumin micelles. Food Chemistry 271:707–14. doi: 10.1016/j.foodchem.2018.07.216.
   PubMed Web of Science ®Google Scholar
• Dulińska, J., D. Gil, J. Zagajewski, J. Hartwich, M. Bodzioch, A. Dembińska-Kieć, T. Langmann, G. Schmitz, and P. Laidler. 2005. Different effect of beta-carotene on proliferation of prostate cancer cells. Biochimica et Biophysica Acta 1740 (2):189–201. doi: 10.1016/j.bbadis.2004.12.004.
   PubMed Web of Science ®Google Scholar
• Ebersole, J. L., J. Lambert, H. Bush, P. E. Huja, and A. Basu. 2018. Serum nutrient levels and aging effects on periodontitis. Nutrients 10 (12):1986. doi: 10.3390/nu10121986.
   Web of Science ®Google Scholar
• Edge, R., D. McGarvey, T. Truscott, and P. B. Biology. 1997. The carotenoids as anti-oxidants-a review. Journal of Photochemistry and Photobiology. B, Biology 41 (3):189–200. doi: 10.1016/S1011-1344(97)00092-4.
   PubMed Web of Science ®Google Scholar
• Eggersdorfer, M., and A. Wyss. 2018. Carotenoids in human nutrition and health. Archives of Biochemistry and Biophysics 652:18–26. doi: 10.1016/j.abb.2018.06.001.
   PubMed Web of Science ®Google Scholar
• El-Salam, M. H. A., and S. El-Shibiny. 2016. Natural biopolymers as nanocarriers for bioactive ingredients used in food industries. In Encapsulations, ed. A. M. Grumezescu, 793–829. Elsevier.
   Google Scholar
• Emanuelli, T., P. R. Augusti, and M. Roehrs. 2017. Protective effects of carotenoids in cardiovascular disease and diabetes. Fruit and Vegetable Phytochemicals: Chemistry and Human Health 347–82.
   Google Scholar
• Ernawita Wahyuono, R. A., Hesse, J. Hipler, U. C. Elsner, P. and Bohm, V. 2017. In vitro lipophilic antioxidant capacity, antidiabetic and antibacterial activity of citrus fruits extracts from Aceh, Indonesia. Antioxidants (Basel) 6 (1):11. doi: 10.3390/antiox6010011.
   Google Scholar
• Esposito, E.,. M. Drechsler, P. Mariani, A. M. Panico, V. Cardile, L. Crascì, F. Carducci, A. C. E. Graziano, R. Cortesi, C. Puglia, et al. 2017. Nanostructured lipid dispersions for topical administration of crocin, a potent antioxidant from saffron (Crocus sativus L.). Materials Science and Engineering: C 71:669–77. doi: 10.1016/j.msec.2016.10.045.
   PubMed Web of Science ®Google Scholar
• Fakhri, S., F. Abbaszadeh, L. Dargahi, and M. Jorjani. 2018. Astaxanthin: A mechanistic review on its biological activities and health benefits. Pharmacological Research 136:1–20. doi: 10.1016/j.phrs.2018.08.012.
   PubMed Web of Science ®Google Scholar
• Fakhri, S., Z. Nouri, S. Z. Moradi, and M. H. Farzaei. 2020. Astaxanthin, COVID‐19 and immune response: Focus on oxidative stress, apoptosis and autophagy. Phytotherapy Research : Ptr 34 (11):2790–2. doi: 10.1002/ptr.6797.
   PubMed Web of Science ®Google Scholar
• Fathalipour, M., H. Fathalipour, O. Safa, P. Nowrouzi-Sohrabi, H. Mirkhani, and S. Hassanipour. 2020. The therapeutic role of carotenoids in diabetic retinopathy: A systematic review. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 13:2347–58. doi: 10.2147/DMSO.S255783.
   PubMed Web of Science ®Google Scholar
• Fernandes, C., C. Oliveira, S. Benfeito, P. Soares, J. Garrido, and F. Borges. 2014. Nanotechnology and antioxidant therapy: An emerging approach for neurodegenerative diseases. Current Medicinal Chemistry 21 (38):4311–27. doi: 10.2174/0929867321666140915141836.
   PubMed Web of Science ®Google Scholar
• Fernández-García, E., and A. Pérez-Gálvez. 2017. Carotenoid:β-cyclodextrin stability is independent of pigment structure. Food Chemistry 221:1317–21. doi: 10.1016/j.foodchem.2016.11.024.
   PubMed Web of Science ®Google Scholar
• Ferreira-Santos, P., R. Aparicio, R. Carrón, M. Á. Sevilla, J. Monroy-Ruiz, and M. Montero. 2018. Lycopene-supplemented diet ameliorates cardiovascular remodeling and oxidative stress in rats with hypertension induced by Angiotensin II. Journal of Functional Foods 47:279–87. doi: 10.1016/j.jff.2018.06.002.
   Web of Science ®Google Scholar
• Fiedor, J., and K. J. N. Burda. 2014. Potential role of carotenoids as antioxidants in human health and disease. Nutrients 6 (2):466–88. doi: 10.3390/nu6020466.
   PubMed Web of Science ®Google Scholar
• Fung, F. K., B. Y. Law, and A. Lo. 2016. Lutein attenuates both apoptosis and autophagy upon cobalt (II) chloride-induced hypoxia in rat Műller cells. PloS One 11 (12):e0167828 doi: 10.1371/journal.pone.0167828.
   PubMed Web of Science ®Google Scholar
• Gajendragadkar, P. R., A. Hubsch, K. M. Maki-Petaja, M. Serg, I. B. Wilkinson, and J. Cheriyan. 2014. Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: A randomised controlled trial. PLoS One 9 (6):e99070. doi: 10.1371/journal.pone.0099070.
   PubMed Web of Science ®Google Scholar
• Galasso, C., C. Corinaldesi, and C. Sansone. 2017. Carotenoids from marine organisms: Biological functions and industrial applications. Antioxidants 6 (4):96. doi: 10.3390/antiox6040096.
   Web of Science ®Google Scholar
• Garcês, A., M. Amaral, J. S. Lobo, and A. Silva. 2018. Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: A review. European Journal of Pharmaceutical Sciences : official Journal of the European Federation for Pharmaceutical Sciences 112:159–67. doi: 10.1016/j.ejps.2017.11.023.
   PubMed Web of Science ®Google Scholar
• Ghanbarzadeh, B., F. Keivani, and M. Mohammadi. 2019. Encapsulation of food ingredients by solid lipid nanoparticles (SLNs). In Lipid-based nanostructures for food encapsulation purposes, ed. S. M. Jafari, 179–216. Elsevier.
   Google Scholar
• Gharib, A., Z. Faezizadeh, and M. Godarzee. 2015. Preparation and characterization of nanoliposomal beta-cryptoxanthin and its effect on proliferation and apoptosis in human leukemia cell line K562. Tropical Journal of Pharmaceutical Research 14 (2):187–94. doi: 10.4314/tjpr.v14i2.1.
   Web of Science ®Google Scholar
• Gholami, M., R. Mohammadi, M. Arzanlou, F. Akbari Dourbash, E. Kouhsari, G. Majidi, S. M. Mohseni, and S. Nazari. 2017. In vitro antibacterial activity of poly (amidoamine)-G7 dendrimer. BMC Infectious Diseases 17 (1):395. doi: 10.1186/s12879-017-2513-7.
   PubMedGoogle Scholar
• Gökalsın, B., and N. C. Sesal. 2016. Lichen secondary metabolite evernic acid as potential quorum sensing inhibitor against Pseudomonas aeruginosa. World Journal of Microbiology & Biotechnology 32 (9):150. doi: 10.1007/s11274-016-2105-5.
   PubMed Web of Science ®Google Scholar
• Gökalsın, B., B. Aksoydan, B. Erman, and N. C. Sesal. 2017. Reducing virulence and biofilm of Pseudomonas aeruginosa by potential quorum sensing inhibitor carotenoid: Zeaxanthin. Microb Ecol 74 (2):466–73. doi: 10.1007/s00248-017-0949-3.
   PubMed Web of Science ®Google Scholar
• Gong, X., and L. P. Rubin. 2015. Role of macular xanthophylls in prevention of common neovascular retinopathies: Retinopathy of prematurity and diabetic retinopathy. Archives of Biochemistry and Biophysics 572:40–8. doi: 10.1016/j.abb.2015.02.004.
   PubMed Web of Science ®Google Scholar
• Gong, X., J. R. Smith, H. M. Swanson, and L. P. Rubin. 2018. Carotenoid lutein selectively inhibits breast cancer cell growth and potentiates the effect of chemotherapeutic agents through ROS-mediated mechanisms. Molecules 23 (4):905. doi: 10.3390/molecules23040905.
   PubMed Web of Science ®Google Scholar
• Gong, X., J. Smith, H. Swanson, and L. J. M. Rubin. 2018. Carotenoid lutein selectively inhibits breast cancer cell growth and potentiates the effect of chemotherapeutic agents through ROS-mediated mechanisms. Molecules 23 (4):905. doi: 10.3390/molecules23040905.
   PubMed Web of Science ®Google Scholar
• Goralczyk, R. 2009. Beta-carotene and lung cancer in smokers: Review of hypotheses and status of research. Nutrition and Cancer 61 (6):767–74. doi: 10.1080/01635580903285155.
   PubMed Web of Science ®Google Scholar
• Grudzinski, W., L. Nierzwicki, R. Welc, E. Reszczynska, R. Luchowski, J. Czub, and W. I. Gruszecki. 2017. Localization and orientation of xanthophylls in a lipid bilayer. Scientific Reports 7 (1):9619. doi: 10.1038/s41598-017-10183-7.
   PubMedGoogle Scholar
• Guedes, A. C., H. M. Amaro, and F. X. Malcata. 2011. Microalgae as sources of carotenoids. Marine Drugs 9 (4):625–44. doi: 10.3390/md9040625.
   PubMed Web of Science ®Google Scholar
• Gul, K., A. Tak, A. Singh, P. Singh, B. Yousuf, and A. A. Wani. 2015. Chemistry, encapsulation, and health benefits of β-carotene-A review. Cogent Food & Agriculture 1 (1):1018696. doi: 10.1080/23311932.2015.1018696.
   Google Scholar
• Gupta, U., H. B. Agashe, A. Asthana, and N. K. Jain. 2006. Dendrimers: Novel polymeric nanoarchitectures for solubility enhancement. Biomacromolecules 7 (3):649–58. doi: 10.1021/bm050802s.
   PubMed Web of Science ®Google Scholar
• Háda, M., V. Nagy, J. Deli, and A. J. M. Agócs. 2012. Hydrophilic carotenoids: Recent progress. Molecules (Basel, Switzerland) 17 (5):5003–12. doi: 10.3390/molecules17055003.
   PubMed Web of Science ®Google Scholar
• Hamadou, A. H., W.-C. Huang, C. Xue, and X. Mao. 2020. Comparison of β-carotene loaded marine and egg phospholipids nanoliposomes. Journal of Food Engineering 283:110055. doi: 10.1016/j.jfoodeng.2020.110055.
   Web of Science ®Google Scholar
• Hammes, H. P. 2018. Diabetic retinopathy: Hyperglycaemia, oxidative stress and beyond. Diabetologia 61 (1):29–38. doi: 10.1007/s00125-017-4435-8.
   PubMed Web of Science ®Google Scholar
• Hantz, H. L., L. F. Young, and K. R. Martin. 2005. Physiologically attainable concentrations of lycopene induce mitochondrial apoptosis in LNCaP human prostate cancer cells. Experimental Biology and Medicine 230 (3):171–9. doi: 10.1177/153537020523000303.
   Web of Science ®Google Scholar
• Heber, D., and Q. Y. Lu. 2002. Overview of mechanisms of action of lycopene. Experimental Biology and Medicine (Maywood, N.J.) 227 (10):920–3. doi: 10.1177/153537020222701013.
   PubMed Web of Science ®Google Scholar
• Hejmadi, M. 2009. Introduction to cancer biology. Bookboon.
   Google Scholar
• Hejri, A., A. Khosravi, K. Gharanjig, and M. Hejazi. 2013. Optimisation of the formulation of β-carotene loaded nanostructured lipid carriers prepared by solvent diffusion method. Food Chemistry 141 (1):117–23. doi: 10.1016/j.foodchem.2013.02.080.
   PubMed Web of Science ®Google Scholar
• Hejri, A., A. Khosravi, K. Gharanjig, and M. M. Davarani. 2019. Effect of edible antioxidants on chemical stability of ß-carotene loaded nanostructured lipid carriers. LWT 113:108272. doi: 10.1016/j.lwt.2019.108272.
   Web of Science ®Google Scholar
• Helgason, T., T. S. Awad, K. Kristbergsson, E. A. Decker, D. J. McClements, and J. Weiss. 2009. Impact of surfactant properties on oxidative stability of beta-carotene encapsulated within solid lipid nanoparticles. Journal of Agricultural and Food Chemistry 57 (17):8033–40. doi: 10.1021/jf901682m.
   PubMed Web of Science ®Google Scholar
• Hempel, J., C. N. Schädle, S. Leptihn, R. Carle, and R. Schweiggert. 2016. Structure related aggregation behavior of carotenoids and carotenoid esters. Journal of Photochemistry and Photobiology A: Chemistry 317:161–74. doi: 10.1016/j.jphotochem.2015.10.024.
   Web of Science ®Google Scholar
• Hidalgo, T., M. Giménez-Marqués, E. Bellido, J. Avila, M. C. Asensio, F. Salles, M. V. Lozano, M. Guillevic, R. Simón-Vázquez, A. González-Fernández, et al. 2017. Chitosan-coated mesoporous MIL-100(Fe) nanoparticles as improved bio-compatible oral nanocarriers. Scientific Reports 7:43099. doi: 10.1038/srep43099.
   PubMed Web of Science ®Google Scholar
• Horuz, T. İ., and K. B. Belibağlı. 2018. Nanoencapsulation by electrospinning to improve stability and water solubility of carotenoids extracted from tomato peels. Food Chemistry 268:86–93. doi: 10.1016/j.foodchem.2018.06.017.
   PubMed Web of Science ®Google Scholar
• Hosein Farzaei, M., R. Bahramsoltani, and R. Rahimi. 2016. Phytochemicals as adjunctive with conventional anticancer therapies. Current Pharmaceutical Design 22 (27):4201–18. doi: 10.2174/1381612822666160601100823.
   PubMed Web of Science ®Google Scholar
• Hu, F., B. Wang Yi, W. Zhang, J. Liang, C. Lin, D. Li, F. Wang, D. Pang, and Y. Zhao. 2012. Carotenoids and breast cancer risk: A meta-analysis and meta-regression. Breast Cancer Research and Treatment 131 (1):239–53. doi: 10.1007/s10549-011-1723-8.
   PubMed Web of Science ®Google Scholar
• Hu, Q., S. Hu, E. Fleming, J.-Y. Lee, and Y. Luo. 2020. Chitosan-caseinate-dextran ternary complex nanoparticles for potential oral delivery of astaxanthin with significantly improved bioactivity. International Journal of Biological Macromolecules 151:747–56. doi: 10.1016/j.ijbiomac.2020.02.170.
   PubMed Web of Science ®Google Scholar
• Hung, L. C., M. Basri, B. A. Tejo, R. Ismail, H. L. L. Nang, H. Abu Hassan, and C. Y. May. 2011. An improved method for the preparations of nanostructured lipid carriers containing heat-sensitive bioactives. Colloids and Surfaces. B, Biointerfaces 87 (1):180–6. doi: 10.1016/j.colsurfb.2011.05.019.
   PubMed Web of Science ®Google Scholar
• Hussein, M. 2015. Cardioprotective Effects of Astaxanthin against Isoproterenol-Induced Cardiotoxicity in Rats. Nutrition and Food Sciences 5:1–6.
   Google Scholar
• Icel, E., A. Icel, T. Uçak, Y. Karakurt, B. Elpeze, F. Keskin Çimen, and H. Süleyman. 2019. The effects of lycopene on alloxan induced diabetic optic neuropathy. Cutaneous and Ocular Toxicology 38 (1):88–92. doi: 10.1080/15569527.2018.1530258.
   PubMed Web of Science ®Google Scholar
• Iqbal, M. A., S. Md, J. K. Sahni, S. Baboota, S. Dang, and J. Ali. 2012. Nanostructured lipid carriers system: Recent advances in drug delivery. Journal of Drug Targeting 20 (10):813–30. doi: 10.3109/1061186X.2012.716845.
   PubMed Web of Science ®Google Scholar
• Irvani, N., R. Hajiaghaee, and A. Zarekarizi. 2018. A review on biosynthesis, health benefits and extraction methods of fucoxanthin, particular marine carotenoids in algae. Journal of Medicinal Plants 3 (67):6–30.
   Google Scholar
• Jafari, S. M., and D. J. McClements. 2017. Nanotechnology approaches for increasing nutrient bioavailability. Advances in Food and Nutrition Research 81 :1–30.
   PubMedGoogle Scholar
• Jafari, S. M., M. Fathi, and I. Mandala. 2015. Emerging product formation. Food waste recovery: Processing technologies and industrial techniques. 293–317. New York: Elsevier.
   Google Scholar
• Jain, A., G. Sharma, G. Ghoshal, P. Kesharwani, B. Singh, U. S. Shivhare, and O. P. Katare. 2018. Lycopene loaded whey protein isolate nanoparticles: An innovative endeavor for enhanced bioavailability of lycopene and anti-cancer activity. International Journal of Pharmaceutics 546 (1–2):97–105. doi: 10.1016/j.ijpharm.2018.04.061.
   PubMed Web of Science ®Google Scholar
• Jain, A., G. Sharma, K. Thakur, K. Raza, U. S. Shivhare, G. Ghoshal, and O. P. Katare. 2019. Beta-carotene-encapsulated solid lipid nanoparticles (BC-SLNs) as promising vehicle for cancer: An investigative assessment. AAPS PharmSciTech 20 (3):100. doi: 10.1208/s12249-019-1301-7.
   PubMed Web of Science ®Google Scholar
• Jain, A., G. Sharma, V. Kushwah, K. Thakur, G. Ghoshal, B. Singh, S. Jain, U. S. Shivhare, and O. P. Katare. 2017. Fabrication and functional attributes of lipidic nanoconstructs of lycopene: An innovative endeavour for enhanced cytotoxicity in MCF-7 breast cancer cells. Colloids and Surfaces. B, Biointerfaces 152:482–91. doi: 10.1016/j.colsurfb.2017.01.050.
   PubMed Web of Science ®Google Scholar
• Jain, S., T. Winuprasith, and M. Suphantharika. 2020. Encapsulation of lycopene in emulsions and hydrogel beads using dual modified rice starch: Characterization, stability analysis and release behaviour during in-vitro digestion. Food Hydrocolloids 104:105730. doi: 10.1016/j.foodhyd.2020.105730.
   Web of Science ®Google Scholar
• Jhala, D., H. Rather, and R. Vasita. 2018. Nano-delivery of food-derived biomolecules: An overview. Functional Food and Human Health: Springer :447–70.
   Google Scholar
• Jiang, G.-L., and M.-J. Zhu. 2019. Preparation of astaxanthin-encapsulated complex with zein and oligochitosan and its application in food processing. LWT 106:179–85. doi: 10.1016/j.lwt.2019.02.055.
   Web of Science ®Google Scholar
• Jiang, H., Z. Wang, Y. Ma, Y. Qu, X. Lu, and H. Luo. 2015. Effects of dietary lycopene supplementation on plasma lipid profile, lipid peroxidation and antioxidant defense system in feedlot Bamei lamb. Asian-Australasian Journal of Animal Sciences 28 (7):958–65. doi: 10.5713/ajas.14.0887.
   PubMed Web of Science ®Google Scholar
• Jiao, Y., D. Li, C. Liu, Y. Chang, J. Song, and Y. Xiao. 2018. Polypeptide–decorated nanoliposomes as novel delivery systems for lutein. RSC Advances 8 (55):31372–81. doi: 10.1039/C8RA05838E.
   PubMed Web of Science ®Google Scholar
• Joye, I. J., and D. J. McClements. 2014. Biopolymer-based nanoparticles and microparticles: Fabrication, characterization, and application. Current Opinion in Colloid & Interface Science 19 (5):417–27. doi: 10.1016/j.cocis.2014.07.002.
   Web of Science ®Google Scholar
• Joye, I. J., G. Davidov-Pardo, and D. J. McClements. 2014. Nanotechnology for increased micronutrient bioavailability. Trends in Food Science & Technology 40 (2):168–82. doi: 10.1016/j.tifs.2014.08.006.
   Web of Science ®Google Scholar
• Kannan, R. M., E. Nance, S. Kannan, and D. A. Tomalia. 2014. Emerging concepts in dendrimer-based nanomedicine: From design principles to clinical applications. Journal of Internal Medicine 276 (6):579–617. doi: 10.1111/joim.12280.
   PubMed Web of Science ®Google Scholar
• Karpiński, T. M., and A. Adamczak. 2019. Fucoxanthin—An antibacterial carotenoid. Antioxidants 8 (8):239. doi: 10.3390/antiox8080239.
   Web of Science ®Google Scholar
• Katouzian, I., A. F. Esfanjani, S. M. Jafari, and S. Akhavan. 2017. Formulation and application of a new generation of lipid nano-carriers for the food bioactive ingredients. Trends in Food Science & Technology 68:14–25. doi: 10.1016/j.tifs.2017.07.017.
   Web of Science ®Google Scholar
• Kaulmann, A., and T. Bohn. 2014. Carotenoids, inflammation, and oxidative stress-implications of cellular signaling pathways and relation to chronic disease prevention. Nutrition Research (New York, N.Y.) 34 (11):907–29. doi: 10.1016/j.nutres.2014.07.010.
   PubMed Web of Science ®Google Scholar
• Khalid, M., and H. S. El-Sawy. 2017. Polymeric nanoparticles: Promising platform for drug delivery. International Journal of Pharmaceutics 528 (1–2):675–91. doi: 10.1016/j.ijpharm.2017.06.052.
   PubMed Web of Science ®Google Scholar
• Khorasani, S., M. Danaei, and M. Mozafari. 2018. Nanoliposome technology for the food and nutraceutical industries. Trends in Food Science & Technology 79:106–15. doi: 10.1016/j.tifs.2018.07.009.
   Web of Science ®Google Scholar
• Kim, L., A. V. Rao, and L. G. Rao. 2002. Effect of lycopene on prostate LNCaP cancer cells in culture. Journal of Medicinal Food 5 (4):181–7. doi: 10.1089/109662002763003320.
   PubMedGoogle Scholar
• Kim, S. O., T. V. A. Ha, Y. J. Choi, and S. Ko. 2014. Optimization of homogenization-evaporation process for lycopene nanoemulsion production and its beverage applications. Journal of Food Science 79 (8):N1604–N10. doi: 10.1111/1750-3841.12472.
   PubMed Web of Science ®Google Scholar
• Kirti, K.,. S. Amita, S. Priti, A. Mukesh Kumar, and S. Jyoti. 2014. Colorful world of microbes: Carotenoids and their applications. Advances in Biology 2014:1–13. doi: 10.1155/2014/837891.
   Google Scholar
• Kong, L., R. Bhosale, and G. R. Ziegler. 2018. Encapsulation and stabilization of β-carotene by amylose inclusion complexes. Food Research International (Ottawa, Ont.) 105:446–52. doi: 10.1016/j.foodres.2017.11.058.
   PubMed Web of Science ®Google Scholar
• Kong, R., X. Zhu, E. S. Meteleva, Y. S. Chistyachenko, L. P. Suntsova, N. E. Polyakov, M. V. Khvostov, D. S. Baev, T. G. Tolstikova, J. Yu, et al. 2017. Enhanced solubility and bioavailability of simvastatin by mechanochemically obtained complexes. International Journal of Pharmaceutics 534 (1–2):108–18. doi: 10.1016/j.ijpharm.2017.10.011.
   PubMed Web of Science ®Google Scholar
• Kopec, R. E., J. Schick, K. L. Tober, K. M. Riedl, D. M. Francis, G. S. Young, S. J. Schwartz, and T. M. Oberyszyn. 2015. Sex differences in skin carotenoid deposition and acute UVB-induced skin damage in SKH-1 hairless mice after consumption of tangerine tomatoes. Molecular Nutrition & Food Research 59 (12):2491–501. doi: 10.1002/mnfr.201500317.
   PubMed Web of Science ®Google Scholar
• Korani, S., M. Korani, T. Sathyapalan, and A. Sahebkar. 2019. Therapeutic effects of Crocin in autoimmune diseases: A review. BioFactors (Oxford, England) 45 (6):835–43. doi: 10.1002/biof.1557.
   PubMed Web of Science ®Google Scholar
• Kowluru, R. A., B. Menon, and D. L. Gierhart. 2008. Beneficial effect of zeaxanthin on retinal metabolic abnormalities in diabetic rats. Investigative Ophthalmology & Visual Science 49 (4):1645–51. doi: 10.1167/iovs.07-0764.
   PubMed Web of Science ®Google Scholar
• Kowluru, R. A., Q. Zhong, J. M. Santos, M. Thandampallayam, D. Putt, and D. L. Gierhart. 2014. Beneficial effects of the nutritional supplements on the development of diabetic retinopathy. Nutrition & Metabolism 11 (1):8. doi: 10.1186/1743-7075-11-8.
   PubMedGoogle Scholar
• Kulczyński, B., A. Gramza-Michałowska, J. Kobus-Cisowska, and D. Kmiecik. 2017. The role of carotenoids in the prevention and treatment of cardiovascular disease–Current state of knowledge. Journal of Functional Foods 38:45–65. doi: 10.1016/j.jff.2017.09.001.
   Web of Science ®Google Scholar
• Kulhari, H., D. Pooja, S. K. Prajapati, and A. S. Chauhan. 2011. Performance evaluation of PAMAM dendrimer based simvastatin formulations. International Journal of Pharmaceutics 405 (1–2):203–9. doi: 10.1016/j.ijpharm.2010.12.002.
   PubMed Web of Science ®Google Scholar
• Kulkarni, M., N. Goge, and A. A. Date. 2020. Development of nanoemulsion preconcentrate of capsanthin with improved chemical stability. Assay and Drug Development Technologies 18 (1):34–44. doi: 10.1089/adt.2019.916.
   PubMed Web of Science ®Google Scholar
• Kumar, D. L., and P. Sarkar. 2017. Nanoemulsions for nutrient delivery in food. In Nanoscience in food and agriculture 5, eds. S. Ranjan, N. Dasgupta, and E. Lichtfouse, Vol. 26, 81–121. Cham: Springer.
   Google Scholar
• Kumar, D. L., J. Mitra, and S. Roopa. 2020. Nanoencapsulation of food carotenoids. In Environmental nanotechnology Volume 3. Environmental chemistry for a sustainable world, eds. N. Dasgupta, S. Ranjan, and E. Lichtfouse, 203–42. Cham: Springer.
   Google Scholar
• Li, D., L. Li, N. Xiao, M. Li, and X. Xie. 2018. Physical properties of oil-in-water nanoemulsions stabilized by OSA-modified starch for the encapsulation of lycopene. Colloids and Surfaces A: Physicochemical and Engineering Aspects 552:59–66. doi: 10.1016/j.colsurfa.2018.04.055.
   Web of Science ®Google Scholar
• Li, H., Y. Xu, X. Sun, S. Wang, J. Wang, J. Zhu, D. Wang, and L. Zhao. 2018. Stability, bioactivity, and bioaccessibility of fucoxanthin in zein-caseinate composite nanoparticles fabricated at neutral pH by antisolvent precipitation. Food Hydrocolloids 84:379–88. doi: 10.1016/j.foodhyd.2018.06.032.
   Web of Science ®Google Scholar
• Li, H., Y. Yuan, J. Zhu, T. Wang, D. Wang, and Y. Xu. 2020. Zein/soluble soybean polysaccharide composite nanoparticles for encapsulation and oral delivery of lutein. Food Hydrocolloids 103:105715. doi: 10.1016/j.foodhyd.2020.105715.
   Web of Science ®Google Scholar
• Li, M., M. R. Zahi, Q. Yuan, F. Tian, and H. Liang. 2016. Preparation and stability of astaxanthin solid lipid nanoparticles based on stearic acid. European Journal of Lipid Science and Technology 118 (4):592–602. doi: 10.1002/ejlt.201400650.
   Web of Science ®Google Scholar
• Li, Y., X. Dou, J. Pang, M. Liang, C. Feng, M. Kong, Y. Liu, X. Cheng, Y. Wang, X. Chen, et al. 2019. Improvement of fucoxanthin oral efficacy via vehicles based on gum Arabic, gelatin and alginate hydrogel: Delivery system for oral efficacy enhancement of functional food ingredients. Journal of Functional Foods 63:103573. doi: 10.1016/j.jff.2019.103573.
   Web of Science ®Google Scholar
• Liang, R., C. F. Shoemaker, X. Yang, F. Zhong, and Q. Huang. 2013. Stability and bioaccessibility of β-carotene in nanoemulsions stabilized by modified starches . Journal of Agricultural and Food Chemistry 61 (6):1249–57. doi: 10.1021/jf303967f.
   PubMed Web of Science ®Google Scholar
• Lin, Q., R. Liang, F. Zhong, A. Ye, Y. Hemar, Z. Yang, and H. Singh. 2019. Self-assembled micelles based on OSA-modified starches for enhancing solubility of beta-carotene: Effect of starch macromolecular architecture. Journal of Agricultural and Food Chemistry 67 (23):6614–24. doi: 10.1021/acs.jafc.9b00355.
   PubMed Web of Science ®Google Scholar
• Lin, Q., R. Liang, P. A. Williams, and F. Zhong. 2018. Factors affecting the bioaccessibility of β-carotene in lipid-based microcapsules: Digestive conditions, the composition, structure and physical state of microcapsules. Food Hydrocolloids 77:187–203. doi: 10.1016/j.foodhyd.2017.09.034.
   Web of Science ®Google Scholar
• Linnewiel-Hermoni, K., M. Khanin, M. Danilenko, G. Zango, Y. Amosi, J. Levy, and Y. Sharoni. 2015. The anti-cancer effects of carotenoids and other phytonutrients resides in their combined activity. Archives of Biochemistry and Biophysics 572:28–35. doi: 10.1016/j.abb.2015.02.018.
   PubMed Web of Science ®Google Scholar
• Liu, C., H. Duan, Z. Zhao, W. Li, L. Ma, X. Fang, C. Wang, and Y. Yang. 2019. Correction: Improving the inhibitory effect of CXCR4 peptide antagonist in tumor metastasis with an acetylated PAMAM dendrimer. RSC Advances 9 (29):16729. doi: 10.1039/C9RA90039J.
   PubMed Web of Science ®Google Scholar
• Liu, G., Y. Zhou, and L. Chen. 2019. Intestinal uptake of barley protein-based nanoparticles for β-carotene delivery. Acta Pharmaceutica Sinica. B 9 (1):87–96. doi: 10.1016/j.apsb.2018.10.002.
   PubMed Web of Science ®Google Scholar
• Liu, X., R. Zhang, D. J. McClements, F. Li, H. Liu, Y. Cao, and H. Xiao. 2018. Nanoemulsion-based delivery systems for nutraceuticals: Influence of long-chain triglyceride (LCT) type on in vitro digestion and astaxanthin bioaccessibility. Food Biophysics 13 (4):412–21. doi: 10.1007/s11483-018-9547-2.
   Web of Science ®Google Scholar
• Lu, P., H. Lin, Y. Gu, L. Li, H. Guo, F. Wang, and X. Qiu. 2015. Antitumor effects of crocin on human breast cancer cells. International Journal of Clinical and Experimental Medicine 8 (11):20316–22.
   PubMed Web of Science ®Google Scholar
• Lu, W., V. A. Maidannyk, and A. S. Lim. 2020. Carotenoids degradation and precautions during processing. In Carotenoids: Properties, processing and applications, ed. C. M. Galanakis, 223–58. Germany: Elsevier.
   Google Scholar
• Luo, X., Y. Zhou, L. Bai, F. Liu, Y. Deng, and D. J. McClements. 2017. Fabrication of β-carotene nanoemulsion-based delivery systems using dual-channel microfluidization: Physical and chemical stability. Journal of Colloid and Interface Science 490:328–35. doi: 10.1016/j.jcis.2016.11.057.
   PubMed Web of Science ®Google Scholar
• Luong, D., P. Kesharwani, R. Deshmukh, M. C. I. Mohd Amin, U. Gupta, K. Greish, and A. K. Iyer. 2016. PEGylated PAMAM dendrimers: Enhancing efficacy and mitigating toxicity for effective anticancer drug and gene delivery. Acta Biomaterialia 43:14–29. doi: 10.1016/j.actbio.2016.07.015.
   PubMed Web of Science ®Google Scholar
• Lyakhov, N., A. Dushkin, and T. Tolstikova. 2013. Efficient and safe medicines developed by Siberian scientists. Russian Chemical Bulletin 62 (1):235–41. doi: 10.1007/s11172-013-0036-y.
   Web of Science ®Google Scholar
• Ma, M., Y. Yuan, S. Yang, Y. Wang, and Z. Lv. 2020. Fabrication and characterization of zein/tea saponin composite nanoparticles as delivery vehicles of lutein. LWT 125:109270. doi: 10.1016/j.lwt.2020.109270.
   Web of Science ®Google Scholar
• Madaan, T., A. N. Choudhary, S. Gyenwalee, S. Thomas, H. Mishra, M. Tariq, D. Vohora, and S. Talegaonkar. 2017. Lutein, a versatile phyto-nutraceutical: An insight on pharmacology, therapeutic indications, challenges and recent advances in drug delivery. PharmaNutrition 5 (2):64–75. doi: 10.1016/j.phanu.2017.02.005.
   Google Scholar
• Maghsoudi, S., B. T. Shahraki, N. Rabiee, R. Afshari, Y. Fatahi, R. Dinarvand, S. Ahmadi, M. Bagherzadeh, M. Rabiee, L. Tayebi, et al. 2019. Recent advancements in aptamer-bioconjugates: Sharpening stones for breast and prostate cancers targeting. Journal of Drug Delivery Science and Technology 53:101146. doi: 10.1016/j.jddst.2019.101146.
   Web of Science ®Google Scholar
• Maghsoudi, S., B. Taghavi Shahraki, N. Rabiee, Y. Fatahi, R. Dinarvand, M. Tavakolizadeh, S. Ahmadi, M. Rabiee, M. Bagherzadeh, A. Pourjavadi, et al. 2020. Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review. International Journal of Nanomedicine 15:4363–92. doi: 10.2147/IJN.S252237.
   PubMed Web of Science ®Google Scholar
• Mao, X., Y. Tian, R. Sun, Q. Wang, J. Huang, and Q. Xia. 2019. Stability study and in vitro evaluation of astaxanthin nanostructured lipid carriers in food industry. Integrated Ferroelectrics 200 (1):208–16. doi: 10.1080/10584587.2019.1592626.
   Web of Science ®Google Scholar
• Maoka, T. 2020. Carotenoids as natural functional pigments. Journal of Natural Medicines 74 (1):1–16. doi: 10.1007/s11418-019-01364-x.
   PubMed Web of Science ®Google Scholar
• Maria, A. G., R. Graziano, and D. O. J. F. Nicolantonio. 2015. Carotenoids: Potential allies of cardiovascular health? Food & Nutrition Research 59 (1):26762. doi: 10.3402/fnr.v59.26762.
   PubMed Web of Science ®Google Scholar
• McClements, D. J. 2015. Encapsulation, protection, and release of hydrophilic active components: Potential and limitations of colloidal delivery systems. Advances in Colloid and Interface Science 219:27–53. doi: 10.1016/j.cis.2015.02.002.
   PubMed Web of Science ®Google Scholar
• McClements, D. J. 2020. Advances in nanoparticle and microparticle delivery systems for increasing the dispersibility, stability, and bioactivity of phytochemicals. Biotechnology Advances 38:107287. doi: 10.1016/j.biotechadv.2018.08.004.
   PubMed Web of Science ®Google Scholar
• Mehrad, B., R. Ravanfar, J. Licker, J. M. Regenstein, and A. Abbaspourrad. 2018. Enhancing the physicochemical stability of β-carotene solid lipid nanoparticle (SLNP) using whey protein isolate. Food Research International (Ottawa, Ont.) 105:962–9. doi: 10.1016/j.foodres.2017.12.036.
   PubMed Web of Science ®Google Scholar
• Meinke, M. C., A. Friedrich, K. Tscherch, S. F. Haag, M. E. Darvin, H. Vollert, N. Groth, J. Lademann, and S. Rohn. 2013. Influence of dietary carotenoids on radical scavenging capacity of the skin and skin lipids. European Journal of Pharmaceutics and Biopharmaceutics 84 (2):365–73. doi: 10.1016/j.ejpb.2012.11.012.
   PubMed Web of Science ®Google Scholar
• Meléndez-Martínez, A. J., G. Britton, I. M. Vicario, and F. J. Heredia. 2007. Relationship between the colour and the chemical structure of carotenoid pigments. Food Chemistry 101 (3):1145–50. doi: 10.1016/j.foodchem.2006.03.015.
   Web of Science ®Google Scholar
• Meléndez-Martínez, A. J., G. Britton, I. M. Vicario, and F. J. Heredia. 2008. Does the carotenoid neoxanthin occur in orange juice? Food Chemistry 107 (1):49–54. doi: 10.1016/j.foodchem.2007.07.022.
   Web of Science ®Google Scholar
• Mezzomo, N., and S. Ferreira. 2016. Carotenoids functionality, sources, and processing by supercritical technology: A review. Journal of Chemistry 2016:1–16. doi: 10.1155/2016/3164312.
   Web of Science ®Google Scholar
• Milani, A., M. Basirnejad, S. Shahbazi, and A. Bolhassani. 2017. Carotenoids: Biochemistry, pharmacology and treatment. British Journal of Pharmacology 174 (11):1290–324. doi: 10.1111/bph.13625.
   PubMed Web of Science ®Google Scholar
• Mishra, D. K., V. Dhote, P. Bhatnagar, and P. K. Mishra. 2012. Engineering solid lipid nanoparticles for improved drug delivery: Promises and challenges of translational research. Drug Delivery and Translational Research 2 (4):238–53. doi: 10.1007/s13346-012-0088-9.
   PubMed Web of Science ®Google Scholar
• Mohammadi, M., E. Assadpour, and S. M. Jafari. 2019. Encapsulation of food ingredients by nanostructured lipid carriers (NLCs). In Lipid-based nanostructures for food encapsulation purposes, ed. Seid Mahdi Jafari, 217–70. New York: Elsevier.
   Google Scholar
• Monroy-Ruiz, J., M. A. Sevilla, R. Carron, and M. J. Montero. 2011. Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats. Pharmacological Research 63 (1):44–50. doi: 10.1016/j.phrs.2010.09.003.
   PubMed Web of Science ®Google Scholar
• Moraes, M., J. M. P. Carvalho, C. R. Silva, S. Cho, M. R. Sola, and S. C. Pinho. 2013. Liposomes encapsulating beta‐carotene produced by the proliposomes method: Characterisation and shelf life of powders and phospholipid vesicles. International Journal of Food Science & Technology 48 (2):274–82. doi: 10.1111/j.1365-2621.2012.03184.x.
   Web of Science ®Google Scholar
• Moschos, M. M., M. Dettoraki, M. Tsatsos, G. Kitsos, and C. Kalogeropoulos. 2017. Effect of carotenoids dietary supplementation on macular function in diabetic patients. Eye and Vision (Lond) 4 (1):23. doi: 10.1186/s40662-017-0088-4.
   PubMedGoogle Scholar
• Murillo, A. G., and M. L. Fernandez. 2016. Potential of dietary non-provitamin A carotenoids in the prevention and treatment of diabetic microvascular complications. Advances in Nutrition 7 (1):14–24. doi: 10.3945/an.115.009803.
   PubMed Web of Science ®Google Scholar
• Murugan, E., D. Geetha Rani, K. Srinivasan, and J. Muthumary. 2013. New surface hydroxylated and internally quaternised poly(propylene imine) dendrimers as efficient biocompatible drug carriers of norfloxacin. Expert Opinion on Drug Delivery 10 (10):1319–34. doi: 10.1517/17425247.2013.801957.
   PubMed Web of Science ®Google Scholar
• Nazemiyeh, E., M. Eskandani, H. Sheikhloie, and H. Nazemiyeh. 2016. Formulation and physicochemical characterization of lycopene-loaded solid lipid nanoparticles. Advanced Pharmaceutical Bulletin 6 (2):235–41. doi: 10.15171/apb.2016.032.
   PubMed Web of Science ®Google Scholar
• Neri-Numa, I. A., H. S. Arruda, M. V. Geraldi, M. R. M. Júnior, and G. M. Pastore. 2020. Natural prebiotic carbohydrates, carotenoids and flavonoids as ingredients in food systems. Current Opinion in Food Science 33:98–107. doi: 10.1016/j.cofs.2020.03.004.
   Web of Science ®Google Scholar
• Nerome, H., S. Machmudah, R. Fukuzato, T. Higashiura, Y.-S. Youn, Y.-W. Lee, and M. Goto. 2013. Nanoparticle formation of lycopene/β-cyclodextrin inclusion complex using supercritical antisolvent precipitation. The Journal of Supercritical Fluids 83:97–103. doi: 10.1016/j.supflu.2013.08.014.
   Web of Science ®Google Scholar
• Ni, X., H. Yu, S. Wang, C. Zhang, and S. Shen. 2017. Astaxanthin inhibits PC-3 xenograft prostate tumor growth in nude mice. Marine Drugs 15 (3):66. doi: 10.3390/md15030066.
   PubMed Web of Science ®Google Scholar
• Niaz, T., S. Shabbir, T. Noor, A. Rahman, H. Bokhari, and M. Imran. 2018. Potential of polymer stabilized nano-liposomes to enhance antimicrobial activity of nisin Z against foodborne pathogens. LWT 96:98–110. doi: 10.1016/j.lwt.2018.05.029.
   Web of Science ®Google Scholar
• Nitta, S. K., and K. Numata. 2013. Biopolymer-based nanoparticles for drug/gene delivery and tissue engineering. International Journal of Molecular Sciences 14 (1):1629–54. doi: 10.3390/ijms14011629.
   PubMed Web of Science ®Google Scholar
• Nováková, E., and N. Moran. 2012. Diversification of genes for carotenoid biosynthesis in aphids following an ancient transfer from a fungus. Molecular Biology and Evolution 29 (1):313–23. doi: 10.1093/molbev/msr206.
   PubMed Web of Science ®Google Scholar
• Olivares, A. M., K. Althoff, G. F. Chen, S. Wu, M. A. Morrisson, M. M. DeAngelis, and N. Haider. 2017. Animal models of diabetic retinopathy. Current Diabetes Reports 17 (10):93. doi: 10.1007/s11892-017-0913-0.
   PubMed Web of Science ®Google Scholar
• Oliveira, D. R. B., M. Michelon, G. de Figueiredo Furtado, R. Sinigaglia-Coimbra, and R. L. Cunha. 2016. β-Carotene-loaded nanostructured lipid carriers produced by solvent displacement method . Food Research International (Ottawa, Ont.) 90:139–46. doi: 10.1016/j.foodres.2016.10.038.
   PubMed Web of Science ®Google Scholar
• Olmos, J., R. Gómez, and R. Vjjmbt. 2015. Apoptosis comparison effects between synthetic and natural β-Carotene from Dunaliella salina on MDA-MB-231 breast cancer cells. Journal of Microbial & Biochemical Technology 7:051–6.
   Google Scholar
• World Health Organization. 2015. World health statistics 2015. Luxembourg: World Health Organization.
   Google Scholar
• Paiva, S. A., and R. M. Russell. 1999. Beta-carotene and other carotenoids as antioxidants. Journal of the American College of Nutrition 18 (5):426–33. doi: 10.1080/07315724.1999.10718880.
   PubMed Web of Science ®Google Scholar
• Paliwal, R., S. R. Paliwal, R. Kenwat, B. D. Kurmi, and M. K. Sahu. 2020. Solid lipid nanoparticles: A review on recent perspectives and patents. Expert Opinion on Therapeutic Patents 30 (3):179–94. doi: 10.1080/13543776.2020.1720649.
   PubMed Web of Science ®Google Scholar
• Palozza, P., A. Catalano, R. E. Simone, M. C. Mele, and A. Cittadini. 2012. Effect of lycopene and tomato products on cholesterol metabolism. Annals of Nutrition & Metabolism 61 (2):126–34. doi: 10.1159/000342077.
   PubMed Web of Science ®Google Scholar
• Pan, L., H. Wang, and K. Gu. 2018. Nanoliposomes as vehicles for astaxanthin: Characterization, in vitro release evaluation and structure. Molecules 23 (11):2822. doi: 10.3390/molecules23112822.
   PubMed Web of Science ®Google Scholar
• Paolino, D., A. Hs Stancampiano, F. Cilurzo, D. Cosco, G. Puglisi, and R. Pignatello. 2011. Nanostructured lipid carriers (NLC) for the topical delivery of lutein. Drug Delivery Letters 1 (1):32–9.
   Google Scholar
• Peng, S. J., J. Li, Y. Zhou, M. Tuo, X. X. Qin, and Q. Yu. 2017. In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells. Genetics and Molecular Research 16 (2):13.
   Web of Science ®Google Scholar
• Peraman, M., and S. Nachimuthu. 2019. Identification and quantification of fucoxanthin in selected carotenoid-producing marine microalgae and evaluation for their chemotherapeutic potential. Pharmacognosy Magazine 15 (64):243. doi: 10.4103/pm.pm_64_19.
   Web of Science ®Google Scholar
• Petrushkina, M., E. Gusev, B. Sorokin, N. Zotko, A. Mamaeva, A. Filimonova, M. Kulikovskiy, Y. Maltsev, I. Yampolsky, E. Guglya, et al. 2017. Fucoxanthin production by heterokont microalgae. Algal Research 24:387–93. doi: 10.1016/j.algal.2017.03.016.
   Google Scholar
• Petyaev, I. M. 2016. Lycopene deficiency in ageing and cardiovascular disease. Oxidative Medicine and Cellular Longevity 2016:3218605. doi: 10.1155/2016/3218605.
   PubMed Web of Science ®Google Scholar
• Pezeshki, A., H. Hamishehkar, B. Ghanbarzadeh, I. Fathollahy, F. Keivani Nahr, M. Khakbaz Heshmati, and M. Mohammadi. 2019. Nanostructured lipid carriers as a favorable delivery system for β-carotene. Food Bioscience 27:11–7. doi: 10.1016/j.fbio.2018.11.004.
   Web of Science ®Google Scholar
• Pinheiro, A. C., M. A. Coimbra, and A. A. Vicente. 2016. In vitro behaviour of curcumin nanoemulsions stabilized by biopolymer emulsifiers–Effect of interfacial composition. Food Hydrocolloids 52:460–7. doi: 10.1016/j.foodhyd.2015.07.025.
   Web of Science ®Google Scholar
• Polyakov, N. E., and L. D. Kispert. 2015. Water soluble biocompatible vesicles based on polysaccharides and oligosaccharides inclusion complexes for carotenoid delivery. Carbohydrate Polymers 128:207–19. doi: 10.1016/j.carbpol.2015.04.016.
   PubMed Web of Science ®Google Scholar
• Polyakov, N. E., T. V. Leshina, E. S. Meteleva, A. V. Dushkin, T. A. Konovalova, and L. D. Kispert. 2009. Water soluble complexes of carotenoids with arabinogalactan. The Journal of Physical Chemistry. B 113 (1):275–82. doi: 10.1021/jp805531q.
   PubMed Web of Science ®Google Scholar
• Przybylska, S. 2020. Lycopene–a bioactive carotenoid offering multiple health benefits: A review. International Journal of Food Science & Technology 55 (1):11–32. doi: 10.1111/ijfs.14260.
   Web of Science ®Google Scholar
• Puglia, C., D. Santonocito, T. Musumeci, V. Cardile, A. C. E. Graziano, L. Salerno, G. Raciti, L. Crascì, A. M. Panico, G. Puglisi, et al. 2019. Nanotechnological approach to increase the antioxidant and cytotoxic efficacy of crocin and crocetin. Planta Medica 85 (3):258–65. doi: 10.1055/a-0732-5757.
   PubMed Web of Science ®Google Scholar
• Qian, C., E. A. Decker, H. Xiao, and D. J. McClements. 2012. Nanoemulsion delivery systems: Influence of carrier oil on beta-carotene bioaccessibility. Food Chemistry 135 (3):1440–7. doi: 10.1016/j.foodchem.2012.06.047.
   PubMed Web of Science ®Google Scholar
• Rahaiee, S., M. Hashemi, S. A. Shojaosadati, S. Moini, and S. H. Razavi. 2017. Nanoparticles based on crocin loaded chitosan-alginate biopolymers: Antioxidant activities, bioavailability and anticancer properties. International Journal of Biological Macromolecules 99:401–8. doi: 10.1016/j.ijbiomac.2017.02.095.
   PubMed Web of Science ®Google Scholar
• Rao, A. R., H. Sindhuja, S. M. Dharmesh, K. U. Sankar, R. Sarada, and G. A. Ravishankar. 2013. Effective inhibition of skin cancer, tyrosinase, and antioxidative properties by astaxanthin and astaxanthin esters from the green alga Haematococcus pluvialis. Journal of Agricultural and Food Chemistry 61 (16):3842–51. doi: 10.1021/jf304609j.
   PubMed Web of Science ®Google Scholar
• Rao, M. P., K. Manjunath, S. T. Bhagawati, and B. S. Thippeswamy. 2014. Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection-preparation, characterisation and in vivo evaluation. International Journal of Pharmaceutics 473 (1–2):485–92. doi: 10.1016/j.ijpharm.2014.07.027.
   PubMed Web of Science ®Google Scholar
• Reboul, E. 2019. Mechanisms of carotenoid intestinal absorption: Where do we stand? Nutrients 11 (4):838. doi: 10.3390/nu11040838.
   PubMed Web of Science ®Google Scholar
• Rehman, A., Q. Tong, S. M. Jafari, E. Assadpour, Q. Shehzad, R. M. Aadil, M. W. Iqbal, M. M. A. Rashed, B. S. Mushtaq, W. Ashraf, et al. 2020. Carotenoid-loaded nanocarriers: A comprehensive review. Advances in Colloid and Interface Science 275:102048. doi: 10.1016/j.cis.2019.102048.
   PubMed Web of Science ®Google Scholar
• Rezaei, A., M. Fathi, and S. M. Jafari. 2019. Nanoencapsulation of hydrophobic and low-soluble food bioactive compounds within different nanocarriers. Food Hydrocolloids 88:146–62. doi: 10.1016/j.foodhyd.2018.10.003.
   Web of Science ®Google Scholar
• Riangjanapatee, P., R. H. Muller, C. M. Keck, and S. Okonogi. 2013. Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol. Die Pharmazie 68 (9):723–31.
   PubMed Web of Science ®Google Scholar
• Ribeiro, H. S., H. P. Schuchmann, R. Engel, E. Walz, and K. Briviba. 2010. Encapsulation of carotenoids. In Encapsulation technologies for active food ingredients and food processing, eds. N. J. Zuidam and V. Nedovic, 211–52. New York, NY: Springer.
   Google Scholar
• Rodríguez-Luna, A., J. Ávila-Román, M. González-Rodríguez, M. Cózar, A. Rabasco, V. Motilva, and E. Talero. 2018. Fucoxanthin-containing cream prevents epidermal hyperplasia and UVB-induced skin erythema in mice. Marine Drugs 16 (10):378. doi: 10.3390/md16100378.
   Web of Science ®Google Scholar
• Rodriguez-Ruiz, V., J. Salatti-Dorado, A. Barzegari, A. Nicolas-Boluda, A. Houaoui, C. Caballo, N. Caballero-Casero, D. Sicilia, J. Bastias Venegas, E. Pauthe, et al. 2018. Astaxanthin-loaded nanostructured lipid carriers for preservation of antioxidant activity. Molecules 23 (10):2601. doi: 10.3390/molecules23102601.
   PubMed Web of Science ®Google Scholar
• Rostamabadi, H., S. R. Falsafi, and S. M. Jafari. 2019. Nanoencapsulation of carotenoids within lipid-based nanocarriers. Journal of Controlled Release: Official Journal of the Controlled Release Society 298:38–67. doi: 10.1016/j.jconrel.2019.02.005.
   PubMed Web of Science ®Google Scholar
• Rowles, J. L., and J. W. Erdman. 2020. Carotenoids and their role in cancer prevention. Biochimica et Biophysica Acta (Bba) - Molecular and Cell Biology of Lipids 1865 (11):158613. doi: 10.1016/j.bbalip.2020.158613.
   PubMed Web of Science ®Google Scholar
• Rwigemera, A., J. Mamelona, and L. J. Martin. 2015. Comparative effects between fucoxanthinol and its precursor fucoxanthin on viability and apoptosis of breast cancer cell lines MCF-7 and MDA-MB-231. Anticancer Research 35 (1):207–19.
   PubMed Web of Science ®Google Scholar
• Sajilata, M., R. Singhal, and M. Kamat. 2008. The carotenoid pigment zeaxanthin—A review. Comprehensive Reviews in Food Science and Food Safety 7 (1):29–49. doi: 10.1111/j.1541-4337.2007.00028.x.
   Web of Science ®Google Scholar
• Sarabandi, K., Z. Rafiee, D. Khodaei, and S. M. Jafari. 2019. Encapsulation of food ingredients by nanoliposomes. In Lipid-based nanostructures for food encapsulation purposes, 347–404. Cambridge, MA: Elsevier.
   Google Scholar
• Scanlon, G., P. Connell, M. Ratzlaff, B. Foerg, D. McCartney, A. Murphy, et al. 2015. Macular pigment optical density is lower in type 2 diabetes, compared with type 1 diabetes and normal controls. Retina 35 (9):1808–16.
   PubMed Web of Science ®Google Scholar
• Seidi, F., R. Jenjob, T. Phakkeeree, and D. Crespy. 2018. Saccharides, oligosaccharides, and polysaccharides nanoparticles for biomedical applications. Journal of Controlled Release : Official Journal of the Controlled Release Society 284:188–212. doi: 10.1016/j.jconrel.2018.06.026.
   PubMed Web of Science ®Google Scholar
• Semenova, M. 2017. Protein–polysaccharide associative interactions in the design of tailor-made colloidal particles. Current Opinion in Colloid & Interface Science 28:15–21. doi: 10.1016/j.cocis.2016.12.003.
   Web of Science ®Google Scholar
• Shegokar, R., and K. Mitri. 2012. Carotenoid lutein: A promising candidate for pharmaceutical and nutraceutical applications. Journal of Dietary Supplements 9 (3):183–210. doi: 10.3109/19390211.2012.708716.
   PubMedGoogle Scholar
• Shishir, M. R. I., L. Xie, C. Sun, X. Zheng, and W. Chen. 2018. Advances in micro and nano-encapsulation of bioactive compounds using biopolymer and lipid-based transporters. Trends in Food Science & Technology 78:34–60. doi: 10.1016/j.tifs.2018.05.018.
   Web of Science ®Google Scholar
• Singh, P., M. Baranwal, and S. M. Reddy. 2016. Antioxidant and cytotoxic activity of carotenes produced by Dunaliella salina under stress. Pharmaceutical Biology 54 (10):2269–75. doi: 10.3109/13880209.2016.1153660.
   PubMed Web of Science ®Google Scholar
• Singh, R., N. Bharti, J. Madan, and S. Hiremath. 2010. Characterization of cyclodextrin inclusion complexes—A review. Journal of Pharmaceutical Science and Technology 2 (3):171–83.
   Google Scholar
• Soh, A. Z., C. B. E. Chee, Y. T. Wang, J. M. Yuan, and W. P. Koh. 2017. Dietary intake of antioxidant vitamins and carotenoids and risk of developing active tuberculosis in a prospective population-based cohort study. American Journal of Epidemiology 186 (4):491–500. doi: 10.1093/aje/kwx132.
   PubMed Web of Science ®Google Scholar
• Soltani, F., M. Ramezani, S. Amel Farzad, A. Mokhtarzadeh, and M. Hashemi. 2017. Comparison study of the effect of alkyl-modified and unmodified PAMAM and PPI dendrimers on solubility and antitumor activity of crocetin. Artificial Cells, Nanomedicine, and Biotechnology 45 (7):1356–62. doi: 10.1080/21691401.2016.1236805.
   PubMed Web of Science ®Google Scholar
• Sopicka-Lizer, M., ed. 2010. High-energy ball milling: Mechanochemical processing of nanopowders. Boca Raton: CRC Press.
   Google Scholar
• Soukoulis, C., and T. Bohn. 2018. A comprehensive overview on the micro- and nano-technological encapsulation advances for enhancing the chemical stability and bioavailability of carotenoids. Critical Reviews in Food Science and Nutrition 58 (1):1–36. doi: 10.1080/10408398.2014.971353.
   PubMed Web of Science ®Google Scholar
• Sowmya Shree, G., K. Yogendra Prasad, H. S. Arpitha, U. R. Deepika, K. Nawneet Kumar, P. Mondal, and P. Ganesan. 2017. β-carotene at physiologically attainable concentration induces apoptosis and down-regulates cell survival and antioxidant markers in human breast cancer (MCF-7) cells. Molecular and Cellular Biochemistry 436 (1–2):1–12. doi: 10.1007/s11010-017-3071-4.
   PubMed Web of Science ®Google Scholar
• Sowmya Shree, G., K. Yogendra Prasad, H. S. Arpitha, U. R. Deepika, K. Nawneet Kumar, P. Mondal, and P. Ganesan. 2017. β-carotene at physiologically attainable concentration induces apoptosis and down-regulates cell survival and antioxidant markers in human breast cancer (MCF-7) cells. Molecular and Cellular Biochemistry 436 (1–2):1–12. doi: 10.1007/s11010-017-3071-4.
   PubMed Web of Science ®Google Scholar
• Sowmya, P. R., B. P. Arathi, K. Vijay, V. Baskaran, and R. Lakshminarayana. 2017. Astaxanthin from shrimp efficiently modulates oxidative stress and allied cell death progression in MCF-7 cells treated synergistically with β-carotene and lutein from greens . Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 106 (Pt A):58–69. doi: 10.1016/j.fct.2017.05.024.
   PubMedGoogle Scholar
• Stahl, W., and H. Sies. 2005. Bioactivity and protective effects of natural carotenoids. Biochimica et Biophysica Acta 1740 (2):101–7. doi: 10.1016/j.bbadis.2004.12.006.
   PubMed Web of Science ®Google Scholar
• Stojiljkovic, N., S. Ilic, V. Jakovljevic, N. Stojanovic, S. Stojnev, H. Kocic, M. Stojanovic, and G. Kocic. 2018. The encapsulation of lycopene in nanoliposomes enhances its protective potential in methotrexate-induced kidney injury model. Oxidative Medicine and Cellular Longevity 2018:2627917. doi: 10.1155/2018/2627917.
   PubMed Web of Science ®Google Scholar
• Šudomová, M., M. A. Shariati, J. Echeverría, I. Berindan-Neagoe, S. M. Nabavi, and S. T. Hassan. 2019. A microbiological, toxicological, and biochemical study of the effects of fucoxanthin, a marine carotenoid, on Mycobacterium tuberculosis and the enzymes implicated in its cell wall: A link between mycobacterial infection and autoimmune diseases. Marine Drugs 17 (11):641. doi: 10.3390/md17110641.
   Web of Science ®Google Scholar
• Surve, D. H., A. T. Paul, and A. B. Jindal. 2019. Nanotechnology based delivery of nutraceuticals. In Environmental Nanotechnology, eds. N. Dasgupta, S. Ranjan, and E. Lichtfouse, Vol. 21, 63–107. Cham: Springer.
   Google Scholar
• Taghavi Shahraki, B., S. Maghsoudi, Y. Fatahi, N. Rabiee, S. Bahadorikhalili, R. Dinarvand, M. Bagherzadeh, and F. Verpoort. 2020. The flowering of mechanically interlocked molecules: Novel approaches to the synthesis of rotaxanes and catenanes. Coordination Chemistry Reviews 423:213484. doi: 10.1016/j.ccr.2020.213484.
   Web of Science ®Google Scholar
• Takeshima, M., M. Ono, T. Higuchi, C. Chen, T. Hara, and S. Nakano. 2014. Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines. Cancer Science 105 (3):252–7. doi: 10.1111/cas.12349.
   PubMed Web of Science ®Google Scholar
• Tamjidi, F., M. Shahedi, J. Varshosaz, and A. Nasirpour. 2013. Nanostructured lipid carriers (NLC): A potential delivery system for bioactive food molecules. Innovative Food Science & Emerging Technologies 19:29–43. doi: 10.1016/j.ifset.2013.03.002.
   Web of Science ®Google Scholar
• Tamjidi, F., M. Shahedi, J. Varshosaz, and A. Nasirpour. 2017. Stability of astaxanthin-loaded nanostructured lipid carriers as affected by pH, ionic strength, heat treatment, simulated gastric juice and freeze-thawing. Journal of Food Science and Technology 54 (10):3132–41. doi: 10.1007/s13197-017-2749-7.
   PubMed Web of Science ®Google Scholar
• Tan, C., B. Feng, X. Zhang, W. Xia, and S. Xia. 2016. Biopolymer-coated liposomes by electrostatic adsorption of chitosan (chitosomes) as novel delivery systems for carotenoids. Food Hydrocolloids 52:774–84. doi: 10.1016/j.foodhyd.2015.08.016.
   Web of Science ®Google Scholar
• Tanaka, S., Y. Yoshimura, R. Kawasaki, C. Kamada, S. Tanaka, C. Horikawa, Y. Ohashi, A. Araki, H. Ito, Y. Akanuma, et al. 2013. Fruit intake and incident diabetic retinopathy with type 2 diabetes. Epidemiology 24 (2):204–11.
   PubMed Web of Science ®Google Scholar
• Tanaka, T., M. Shnimizu, and H. Moriwaki. 2012. Cancer chemoprevention by carotenoids. Molecules (Basel, Switzerland) 17 (3):3202–42. doi: 10.3390/molecules17033202.
   PubMed Web of Science ®Google Scholar
• Tang, L., T. Jin, X. Zeng, and J. S. Wang. 2005. Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice. Journal of Nutrition 135 (2):287–90. doi: 10.1093/jn/135.2.287.
   PubMed Web of Science ®Google Scholar
• Teixé-Roig, J., G. Oms-Oliu, S. Ballesté-Muñoz, I. Odriozola-Serrano, and O. Martín-Belloso. 2020. Improving the In Vitro Bioaccessibility of β-Carotene Using Pectin Added Nanoemulsions. Foods 9 (4):447. doi: 10.3390/foods9040447.
   PubMed Web of Science ®Google Scholar
• Thamaket, P., and P. Raviyan. 2015. Preparation and physical properties of carotenoids encapsulated in chitosan cross-linked tripolyphosphate nanoparticles. Food and Applied Bioscience Journal 3 (1):69–84.
   Google Scholar
• Thanki, K., R. P. Gangwal, A. T. Sangamwar, and S. Jain. 2013. Oral delivery of anticancer drugs: Challenges and opportunities. Journal of Controlled Release : official Journal of the Controlled Release Society 170 (1):15–40. doi: 10.1016/j.jconrel.2013.04.020.
   PubMed Web of Science ®Google Scholar
• Thies, F., L. M. Mills, S. Moir, and L. F. Masson. 2017. Cardiovascular benefits of lycopene: Fantasy or reality? The Proceedings of the Nutrition Society 76 (2):122–9. doi: 10.1017/S0029665116000744.
   PubMed Web of Science ®Google Scholar
• Thomas, S. E., and E. H. Harrison. 2016. Mechanisms of selective delivery of xanthophylls to retinal pigment epithelial cells by human lipoproteins. Journal of Lipid Research 57 (10):1865–78. doi: 10.1194/jlr.M070193.
   PubMed Web of Science ®Google Scholar
• Tolentino, M. S., A. J. Tolentino, and M. J. Tolentino. 2016. Current and investigational drugs for the treatment of diabetic retinopathy. Expert Opinion on Investigational Drugs 25 (9):1011–22. doi: 10.1080/13543784.2016.1201062.
   PubMed Web of Science ®Google Scholar
• Toniazzo, T.,. I. F. Berbel, S. Cho, C. S. Fávaro-Trindade, I. C. Moraes, and S. C. Pinho. 2014. β-carotene-loaded liposome dispersions stabilized with xanthan and guar gums: Physico-chemical stability and feasibility of application in yogurt. Lwt - Food Science and Technology 59 (2):1265–73. doi: 10.1016/j.lwt.2014.05.021.
   Web of Science ®Google Scholar
• Toti, E., C.-Y. O. Chen, M. Palmery, D. Villaño Valencia, and I. Peluso. 2018. Non-provitamin A and provitamin A carotenoids as immunomodulators: Recommended dietary allowance, therapeutic index, or personalized nutrition? Oxidative Medicine and Cellular Longevity 2018:1–20. doi: 10.1155/2018/4637861.
   Web of Science ®Google Scholar
• Uysal, E. 2017. Top 100 cited classic articles in breast cancer research. European Journal of Breast Health 13 (3):129–37. doi: 10.5152/ejbh.2017.3480.
   PubMed Web of Science ®Google Scholar
• Van Hoang, D., N. M. Pham, A. H. Lee, D. N. Tran, and C. W. Binns. 2018. Dietary carotenoid intakes and prostate cancer risk: A case-control study from Vietnam. Nutrients 10 (1):70. doi: 10.3390/nu10010070.
   Web of Science ®Google Scholar
• Verghese, M., J. E. Richardson, J. Boateng, L. A. Shackelfor, C. Howard, L. T. Walker, and C. B. Chawan. 2008. Dietary lycopene has a protective effect on cardiovascular disease in New Zealand male rabbits. Journal of Biological Sciences 8 (2):268–77. doi: 10.3923/jbs.2008.268.277.
   Google Scholar
• Verma, D., N. Gulati, S. Kaul, S. Mukherjee, and U. Nagaich. 2018. Protein based nanostructures for drug delivery. Journal of Pharmaceutics 2018:9285854. doi: 10.1155/2018/9285854.
   PubMed Web of Science ®Google Scholar
• Vijay, K., P. R.-R. Sowmya, B. P. Arathi, S. Shilpa, H. J. Shwetha, M. Raju, V. Baskaran, and R. Lakshminarayana. 2018. Low-dose doxorubicin with carotenoids selectively alters redox status and upregulates oxidative stress-mediated apoptosis in breast cancer cells. Food and Chemical Toxicology 118:675–90. doi: 10.1016/j.fct.2018.06.027.
   PubMed Web of Science ®Google Scholar
• Viuda-Martos, M., E. Sanchez-Zapata, E. Sayas-Barbera, E. Sendra, J. A. Perez-Alvarez, and J. Fernandez-Lopez. 2014. Tomato and tomato byproducts. Human health benefits of lycopene and its application to meat products: A review. Critical Reviews in Food Science and Nutrition 54 (8):1032–49. doi: 10.1080/10408398.2011.623799.
   PubMed Web of Science ®Google Scholar
• Wais, U., A. W. Jackson, T. He, and H. Zhang. 2016. Nanoformulation and encapsulation approaches for poorly water-soluble drug nanoparticles. Nanoscale 8 (4):1746–69. doi: 10.1039/c5nr07161e.
   PubMed Web of Science ®Google Scholar
• Wang, M., Y. Fu, G. Chen, Y. Shi, X. Li, H. Zhang, and Y. Shen. 2018. Fabrication and characterization of carboxymethyl chitosan and tea polyphenols coating on zein nanoparticles to encapsulate β-carotene by anti-solvent precipitation method. Food Hydrocolloids 77:577–87. doi: 10.1016/j.foodhyd.2017.10.036.
   Web of Science ®Google Scholar
• Wang, Q., Y. Zhao, L. Guan, Y. Zhang, Q. Dang, P. Dong, J. Li, and X. Liang. 2017. Preparation of astaxanthin-loaded DNA/chitosan nanoparticles for improved cellular uptake and antioxidation capability. Food Chemistry 227:9–15. doi: 10.1016/j.foodchem.2017.01.081.
   PubMed Web of Science ®Google Scholar
• Wang, S., Y.-Y. Wu, X. Wang, P. Shen, Q. Jia, S. Yu, Y. Wang, X. Li, W. Chen, A. Wang, et al. 2020. Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation. Aging 12 (9):8167–90. doi: 10.18632/aging.103132.
   PubMedGoogle Scholar
• Wang, Y., R. Cui, Y. Xiao, J. Fang, and Q. Xu. 2015. Effect of carotene and lycopene on the risk of prostate cancer: A systematic review and dose-response meta-analysis of observational studies. PloS One 10 (9):e0137427. doi: 10.1371/journal.pone.0137427.
   PubMed Web of Science ®Google Scholar
• Wei, Y., C. Sun, L. Dai, X. Zhan, and Y. Gao. 2018. Structure, physicochemical stability and in vitro simulated gastrointestinal digestion properties of β-carotene loaded zein-propylene glycol alginate composite nanoparticles fabricated by emulsification-evaporation method. Food Hydrocolloids 81:149–58. doi: 10.1016/j.foodhyd.2018.02.042.
   Web of Science ®Google Scholar
• Wei, Z., and Q. Huang. 2019. Assembly of protein-polysaccharide complexes for delivery of bioactive ingredients: A perspective paper. Journal of Agricultural and Food Chemistry 67 (5):1344–52. doi: 10.1021/acs.jafc.8b06063.
   PubMed Web of Science ®Google Scholar
• Wijaya, W., A. R. Patel, A. D. Setiowati, and P. Van der Meeren. 2017. Functional colloids from proteins and polysaccharides for food applications. Trends in Food Science & Technology 68:56–69. doi: 10.1016/j.tifs.2017.08.003.
   Web of Science ®Google Scholar
• Witayaudom, P., and U. Klinkesorn. 2019. Influence of lipid content and dilution on properties and stability of nanostructured lipid carriers (NLCs) prepared from rambutan (Nephelium lappaceum L.) kernel fat and evaluation of their β-carotene loading capacity. Journal of Dispersion Science and Technology 40 (11):1600–10. doi: 10.1080/01932691.2018.1523011.
   Web of Science ®Google Scholar
• Wu, Z., C. Zhao, R. Li, F. Ye, Y. Zhou, and G. Zhao. 2019. Insights into micellization of octenylsuccinated oat β-glucan and uptake and controlled release of β-Carotene by the resultant micelles. Journal of Agricultural and Food Chemistry 67 (26):7416–27. doi: 10.1021/acs.jafc.8b06645.
   PubMed Web of Science ®Google Scholar
• Xavier, A. A. O., and A. Pérez-Gálvez. 2016. Carotenoids as a source of antioxidants in the diet. In Carotenoids in nature, ed. C. Stange, Vol. 79, 359–75. Cham: Springer.
   Google Scholar
• Xia, S., C. Tan, Y. Zhang, S. Abbas, B. Feng, X. Zhang, and F. Qin. 2015. Modulating effect of lipid bilayer-carotenoid interactions on the property of liposome encapsulation. Colloids and Surfaces. B, Biointerfaces 128:172–80. doi: 10.1016/j.colsurfb.2015.02.004.
   PubMed Web of Science ®Google Scholar
• Xu, Y., X. Y. Ma, W. Gong, X. Li, H. B. Huang, and X. M. Zhu. 2020. Nanoparticles based on carboxymethylcellulose-modified rice protein for efficient delivery of lutein. Food & Function 11 (3):2380–94. doi: 10.1039/c9fo02439e.
   PubMed Web of Science ®Google Scholar
• Yabuzaki, J. J. D. 2017. Carotenoids database: Structures, chemical fingerprints and distribution among organisms. Database 2017 :bax004.
   Google Scholar
• Yang, J., Y. Zhou, and L. Chen. 2014. Elaboration and characterization of barley protein nanoparticles as an oral delivery system for lipophilic bioactive compounds. Food & Function 5 (1):92–101. doi: 10.1039/C3FO60351B.
   PubMed Web of Science ®Google Scholar
• Yang, Y., I. Yang, M. Cao, Z.-Y. Su, R. Wu, Y. Guo, M. Fang, and A.-N. Kong. 2018. Fucoxanthin elicits epigenetic modifications, Nrf2 activation and blocking transformation in mouse skin JB6 P + cells. The AAPS Journal 20 (2):32. doi: 10.1208/s12248-018-0197-6.
   PubMed Web of Science ®Google Scholar
• Yang, Y., I. Yang, M. Cao, Z.-Y. Su, R. Wu, Y. Guo, M. Fang, and A.-N. Kong. 2018. Fucoxanthin elicits epigenetic modifications, Nrf2 activation and blocking transformation in mouse skin JB6 P + cells. The AAPS Journal 20 (2):32. doi: 10.1208/s12248-018-0197-6.
   PubMed Web of Science ®Google Scholar
• Yi, J., T. I. Lam, W. Yokoyama, L. W. Cheng, and F. Zhong. 2014. Controlled release of β-carotene in β-lactoglobulin-dextran-conjugated nanoparticles' in vitro digestion and transport with Caco-2 monolayers. Journal of Agricultural and Food Chemistry 62 (35):8900–7. doi: 10.1021/jf502639k.
   PubMed Web of Science ®Google Scholar
• You, Z. Q., Q. Wu, X. M. Zhou, X. S. Zhang, B. Yuan, L. L. Wen, W.-D. Xu, S. Cui, X.-l. Tang, and X. Zhang. 2019. Receptor-mediated delivery of astaxanthin-loaded nanoparticles to neurons: An enhanced potential for subarachnoid hemorrhage treatment. Frontiers in Neuroscience 13 (989).
   Google Scholar
• Young, A., and G. Lowe. 2018. Carotenoids—antioxidant properties. New York: Multidisciplinary Digital Publishing Institute.
   Google Scholar
• Yousefi, M., A. Narmani, and S. M. Jafari. 2020. Dendrimers as efficient nanocarriers for the protection and delivery of bioactive phytochemicals. Advances in Colloid and Interface Science 278:102125. doi: 10.1016/j.cis.2020.102125.
   PubMed Web of Science ®Google Scholar
• Yousefi, M., P. Orojzadeh, and S. M. Jafari. 2019. Nanoencapsulation of food ingredients by dendrimers. In Biopolymer nanostructures for food encapsulation purposes, ed. S. M. Jafari, 607–25. London: Academic Press.
   Google Scholar
• Yu, H., L. Wark, H. Ji, L. Willard, Y. Jaing, J. Han, H. He, E. Ortiz, Y. Zhang, D. M. Medeiros, et al. 2013. Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice. Molecular Nutrition & Food Research 57 (7):1158–69. doi: 10.1002/mnfr.201200642.
   PubMed Web of Science ®Google Scholar
• Zaheer, K.-J. F. 2017. Hen egg carotenoids (lutein and zeaxanthin) and nutritional impacts on human health: A review. CyTA - Journal of Food 15 (3):474–87. doi: 10.1080/19476337.2016.1266033.
   Web of Science ®Google Scholar
• Zare, M., Z. Norouzi Roshan, E. Assadpour, and S. M. Jafari. 2020. Improving the cancer prevention/treatment role of carotenoids through various nano-delivery systems. Critical Reviews in Food Science and Nutrition 1–13.
   Web of Science ®Google Scholar
• Zerbini, G., S. Maestroni, V. Turco, and A. Secchi. 2017. The eye as a window to the microvascular complications of diabetes. In Management of Diabetic Retinopathy, eds. F. Bandello, M. A. Zarbin, R. Lattanzio, and I. Zucchiatti, Vol. 60, 6–15. Switzerland: Karger Publishers.
   Google Scholar
• Zhang, D., L. Wang, X. Zhang, D. Bao, and Y. Zhao. 2018. Polymeric micelles for pH-responsive lutein delivery. Journal of Drug Delivery Science and Technology 45:281–6. doi: 10.1016/j.jddst.2018.03.023.
   Web of Science ®Google Scholar
• Zhang, J., and C. A. Peng. 2019. Enhanced proliferation and differentiation of mesenchymal stem cells by astaxanthin-encapsulated polymeric micelles. PLoS One 14 (5):e0216755 doi: 10.1371/journal.pone.0216755.
   PubMed Web of Science ®Google Scholar
• Zhang, L., and H. Wang. 2015. Multiple mechanisms of anti-cancer effects exerted by astaxanthin. Marine Drugs 13 (7):4310–30. doi: 10.3390/md13074310.
   PubMed Web of Science ®Google Scholar
• Zhang, L., D. G. Hayes, G. Chen, and Q. Zhong. 2013. Transparent dispersions of milk-fat-based nanostructured lipid carriers for delivery of β-carotene. Journal of Agricultural and Food Chemistry 61 (39):9435–43. doi: 10.1021/jf403512c.
   PubMed Web of Science ®Google Scholar
• Zhang, X., D. Spiegelman, L. Baglietto, L. Bernstein, D. A. Boggs, P. A. van den Brandt, J. E. Buring, S. M. Gapstur, G. G. Giles, E. Giovannucci, et al. 2012. Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: A pooled analysis of 18 prospective cohort studies. The American Journal of Clinical Nutrition 95 (3):713–25. doi: 10.3945/ajcn.111.014415.
   PubMed Web of Science ®Google Scholar
• Zhang, Y.-P., R.-X. Chu, and H. Liu. 2014. Vitamin A intake and risk of melanoma: A meta-analysis. PloS One 9 (7):e102527 doi: 10.1371/journal.pone.0102527.
   PubMed Web of Science ®Google Scholar
• Zhang, Z., R. Zhang, and D. J. McClements. 2016. Encapsulation of β-carotene in alginate-based hydrogel beads: Impact on physicochemical stability and bioaccessibility. Food Hydrocolloids 61:1–10. doi: 10.1016/j.foodhyd.2016.04.036.
   Web of Science ®Google Scholar
• Zhao, C., L. Wei, B. Yin, F. Liu, J. Li, X. Liu, J. Wang, and Y. Wang. 2020. Encapsulation of lycopene within oil-in-water nanoemulsions using lactoferrin: Impact of carrier oils on physicochemical stability and bioaccessibility. International Journal of Biological Macromolecules 153:912–920. doi: 10.1016/j.ijbiomac.2020.03.063.
   PubMed Web of Science ®Google Scholar
• Zhao, T., X. Yan, L. Sun, T. Yang, X. Hu, Z. He, F. Liu, and X. Liu. 2019. Research progress on extraction, biological activities and delivery systems of natural astaxanthin. Trends in Food Science & Technology 91:354–61. doi: 10.1016/j.tifs.2019.07.014.
   Web of Science ®Google Scholar
• Zhao, Y., Z. Xin, N. Li, S. Chang, Y. Chen, L. Geng, H. Chang, H. Shi, and Y.-Z. Chang. 2018. Nano-liposomes of lycopene reduces ischemic brain damage in rodents by regulating iron metabolism. Free Radical Biology & Medicine 124:1–11. doi: 10.1016/j.freeradbiomed.2018.05.082.
   PubMed Web of Science ®Google Scholar
• Zigangirova, N. A., E. Y. Morgunova, E. D. Fedina, N. V. Shevyagina, T. G. Borovaya, V. G. Zhukhovitsky, N. H. Kyle, and I. M. Petyaev. 2017. Lycopene inhibits propagation of chlamydia infection. Scientifica 2017:1478625. doi: 10.1155/2017/1478625.
   PubMed Web of Science ®Google Scholar
• Žmitek, K., J. Žmitek, M. R. Butina, H. Hristov, T. Pogačnik, and I. Pravst. 2020. Dietary lutein supplementation protects against ultraviolet-radiation-induced erythema: Results of a randomized double-blind placebo-controlled study. Journal of Functional Foods 75:104265. doi: 10.1016/j.jff.2020.104265.
   Web of Science ®Google Scholar
• Zu, K., L. Mucci, B. A. Rosner, S. K. Clinton, M. Loda, M. J. Stampfer, and E. Giovannucci. 2014. Dietary lycopene, angiogenesis, and prostate cancer: A prospective study in the prostate-specific antigen era. Journal of the National Cancer Institute 106 (2):djt430. doi: 10.1093/jnci/djt430.
   PubMedGoogle Scholar
• Мошетова, И., И. Воробьева, И. Алексеев, and ИJВо. Михалева. 2015. Результаты лечения антиоксидантными и ангиопротекторными препаратами пациентов с диабетической ретинопатией и возрастной макулярной дегенерацией при сахарном диабете 2-го типа. Vestnik Oftalmologii 131 (3):34–44.
   Google Scholar