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Practical considerations will ensure the continued success of pre-harvest biocontrol using non-aflatoxigenic Aspergillus flavus strains

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References

  • Abbas, H. K., C. Accinelli, and W. T. Shier. 2017. Biological control of aflatoxin contamination in U.S. crops and the use of bioplastic formulations of Aspergillus flavus biocontrol strains to optimize application strategies. Journal of Agricultural and Food Chemistry 65 (33):7081–7. doi: 10.1021/acs.jafc.7b01452.
  • Abbas, H. K., R. M. Zablotowicz, H. A. Bruns, and C. A. Abel. 2006. Biocontrol of aflatoxin in corn by inoculation with non-aflatoxigenic Aspergillus flavus isolates. Biocontrol Science and Technology 16, 437–49. doi: 10.1080/09583150500532477.
  • Abbas, H. K., R. M. Zablotowicz, B. W. Horn, N. A. Phillips, B. J. Johnson, X. Jin, and C. A. Abel. 2011. Comparison of major biocontrol strains of non-aflatoxigenic Aspergillus flavus for the reduction of aflatoxins and cyclopiazonic acid in maize. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 28 (2):198–208. doi: 10.1080/19440049.2010.544680.
  • Affeldt, K. J., M. Brodhagen, and N. P. Keller. 2012. Aspergillus oxylipin signaling and quorum sensing pathways depend on g protein-coupled receptors. Toxins 4 (9):695–717. doi: 10.3390/toxins4090695.
  • Afriyie-Gyawu, E., N. A. Ankrah, H. J. Huebner, M. Ofosuhene, J. Kumi, N. M. Johnson, L. Tang, L. Xu, P. E. Jolly, W. O. Ellis, et al. 2008. NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis. I. Study design and clinical outcomes. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 25 (1):76–87. doi: 10.1080/02652030701458105.
  • Agbetiameh, D., A. Ortega-Beltran, R. T. Awuah, J. Atehnkeng, A. Elzein, P. J. Cotty, and R. Bandyopadhyay. 2020. Field efficacy of two atoxigenic biocontrol products for mitigation of aflatoxin contamination in maize and groundnut in Ghana. Biological Control 150:e104351. doi: 10.1016/j.biocontrol.2020.104351.
  • Alsuhaiban, A. M. A. 2018. Effects of storage periods and temperature on mold prevalence and aflatoxin contamination in nuts. Pakistan Journal of Nutrition 17 (5):219–27. doi: 10.3923/pjn.2018.219.227.
  • Alves, I., A. A. Houle, J. G. Hussin, and P. Awadalla. 2017. The impact of recombination on human mutation load and disease. Philosophical Transactions of the Royal Society B: Biological Sciences 372 (1736):e20160465. doi: 10.1098/rstb.2016.0465.
  • Armbrecht, B. H., F. A. Hodges, H. R. Smith, and A. A. Nelson. 1963. Mycotoxins. I. Studies of aflatoxin derived from contaminated peanut meal and certain strains of Aspergillus flavus. Journal of AOAC International 46 (5):805–17. doi: 10.1093/jaoac/46.5.805.
  • Andrews, M., I. Carbone, A. Binder, N. Breakfield, O. Duckworth, K. Francis, S. L. Harris, L. Kinkel, J. Leach, G. Maloney, et al. 2020. Agriculture and the Microbiome. Issue Paper 68. Council for Agricultural Science and Technology (CAST), Ames, Iowa. USA.
  • Arabatzis, M., and A. Velegraki. 2013. Sexual reproduction in the opportunistic human pathogen Aspergillus terreus. Mycologia 105 (1):71–9. doi: 10.3852/11-426.
  • Atehnkeng, J., P. S. Ojiambo, P. J. Cotty, and R. Bandyopadhyay. 2014. Field efficacy of a mixture of atoxigenic Aspergillus flavus Link:Fr vegetative compatibility groups in preventing aflatoxin contamination in maize (Zea mays L.). Biological Control 72:62–70. doi: 10.1016/j.biocontrol.2014.02.009.
  • Atehnkeng, J., P. S. Ojiambo, T. Ikotun, R. A. Sikora, P. J. Cotty, and R. Bandyopadhyay. 2008. Evaluation of atoxigenic isolates of Aspergillus flavus as potential biocontrol agents for aflatoxin in maize. Food Additives & Contaminants: Part A 25 (10):1264–71. doi: 10.1080/02652030802112635.
  • Austwick, P. K. C., and G. Ayerst. 1963. Groundnut microflora and toxicity. Chemistry and Industry (London) 41:55–61.
  • Azziz-Baumgartner, E., K. Lindblade, K. Gieseker, H. S. Rogers, S. Kieszak, H. Njapau, R. Schleicher, L. F. McCoy, A. Misore, K. DeCock, et al. 2005. Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004. Environmental Health Perspectives 113 (12):1779–83. doi: 10.1289/ehp.8384.
  • Bandyopadhyay, R., J. Atehnkeng, A. Ortega-Beltran, A. Akande, T. D. O. Falade, and P. J. Cotty. 2019. Ground-Truthing” efficacy of biological control for aflatoxin mitigation in farmers’ fields in Nigeria: From field trials to commercial usage, a 10-year study. Frontiers in Microbiology 10:e2528. doi: 10.3389/fmicb.2019.02528.
  • Bandyopadhyay, R., A. Ortega-Beltran, A. Akande, C. Mutegi, J. Atehnkeng, L. Kaptoge, A. L. Senghor, B. N. Adhikari, and P. J. Cotty. 2016. Biological control of aflatoxins in Africa: Current status and potential challenges in the face of climate change. World Mycotoxin Journal 9 (5):771–89. doi: .
  • Battilani, P., M. Camardo Leggieri, V. Rossi, and P. Giorni. 2013. AFLA-maize, a mechanistic model for Aspergillus flavus infection and aflatoxin B1 contamination in maize. Computers and Electronics in Agriculture 94:38–46. doi: 10.1016/j.compag.2013.03.005.
  • Battilani, P., P. Toscano, H. J. Van der Fels-Klerx, A. Moretti, M. Camardo Leggieri, C. Brera, A. Rortais, T. Goumperis, and T. Robinson. 2016. Aflatoxin B1 contamination in maize in Europe increases due to climate change. Scientific Reports 6:24328. doi: 10.1038/srep24328.
  • Bayman, P., and P. J. Cotty. 1991. Vegetative compatibility and genetic diversity in the Aspergillus flavus population of a single field. Canadian Journal of Botany 69 (8):1707–11. doi: 10.1139/b91-216.
  • Bbosa, G. S., D. Kitya, A. Lubega, J. Ogwal-Okeng, W. W. Anokbonggo, and D. B. Kyegombe. 2013. Review of the biological and health effects of aflatoxins on body organs and body systems. In Aflatoxins - Recent advances and future prospects, ed. Mehdi Razzaghi-Abyaneh. London: IntechOpen. doi: 10.5772/51201.
  • Benjamin, C. R. 1955. Ascocarps of Aspergillus and Penicillium. Mycologia 47 (5):669–87. doi: 10.2307/3755578.
  • Benkerroum, N. 2020. Aflatoxins: Producing-molds, structure, health issues and incidence in Southeast Asian and Sub-Saharan African Countries. International Journal of Environmental Research and Public Health 17:e1215. doi: 10.3390/ijerph17041215.
  • Bernhoft, A., M. Keblys, E. Morrison, H. J. S. Larsen, and A. Flåøyen. 2004. Combined effects of selected penicillium mycotoxins on in vitro proliferation of porcine lymphocytes. Mycopathologia 158 (4):441–50. doi:. doi: 10.1007/s11046-004-2843-z.
  • Bingham, A. K., H. J. Huebner, T. D. Phillips, and J. E. Bauer. 2004. Identification and reduction of urinary aflatoxin metabolites in dogs. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 42 (11):1851–8. doi: 10.1016/j.fct.2004.06.016.
  • Blount, W. P. 1961. Turkey “X” disease. Turkeys 9:52–77.
  • Boonen, J., S. V. Malysheva, L. Taevernier, J. D. Di Mavungu, S. D. Saeger, and B. De Spiegeleer. 2012. Human skin penetration of selected model mycotoxins. Toxicology 301 (1-3):21–32. doi: 10.1016/j.tox.2012.06.012.
  • Bradburn, N., R. D. Coker, and G. Blunden. 1994. The aetiology of Turkey “X” disease. Phytochemistry 35 (3):817. . (00)90613-7 doi: 10.1016/S0031-9422(00)90613-7.
  • Brekke, O. L., A. J. Peplinski, and E. B. Lancaster. 1977. Aflatoxin inactivation in corn by aqua ammonia. Transactions of the American Society of Agricultural Engineers 20:1160–8. doi: 10.13031/2013.35721.
  • Burdock, G. A., and W. G. Flamm. 2000. Review Article: Safety assessment of the mycotoxin cyclopiazonic acid. International Journal of Toxicology 19 (3):195–218. doi: 10.1080/10915810050074964.
  • Calistru, C., M. McLean, and P. Berjak. 1997. In vitro studies on the potential for biological control of Aspergillus flavus and Fusarium moniliforme by Trichoderma species. Mycopathologia 139 (2):115–21. doi:
  • Camiletti, B. X., J. Moral, C. M. Asensio, A. K. Torrico, E. I. Lucini, M. de la Paz Giménez-Pecci, and T. J. Michailides. 2018. Characterization of Argentinian endemic Aspergillus flavus isolates and their potential use as biocontrol agents for mycotoxins in maize. Phytopathology 108 (7):818–28. doi: 10.1094/PHYTO-07-17-0255-R.
  • Carbone, I., J. L. Jakobek, J. H. Ramirez-Prado, and B. W. Horn. 2007a. Recombination, balancing selection and adaptive evolution in the aflatoxin gene cluster of Aspergillus parasiticus. Molecular Ecology 16 (20):4401–17. doi: 10.1111/j.1365-294X.2007.03464.x.
  • Carbone, I., J. H. Ramirez-Prado, J. L. Jakobek, and B. W. Horn. 2007b. Gene duplication, modularity and adaptation in the evolution of the aflatoxin gene cluster. BMC Evolutionary Biology 7:111. doi: 10.1186/1471-2148-7-111.
  • Cardwell, K., P. J. Cotty, R. Bandyopadhyay, C. Mutegi, F. Nelson, M. Marwa, and V. Manyong. 2015. Building an Aflatoxin Safe East African Community. Technical Policy Paper 6. International Institute of Tropical Agriculture, Tanzania. Accessed September 23, 2020. https://aflasafe.com/wp-content/uploads/pdf/TPP-6-Biocontrol-for-Aflatoxin.pdf
  • Cary, J. W., K. Rajasekaran, R. L. Brown, M. Luo, Z. Y. Chen, and D. Bhatnagar. 2011. Developing resistance to aflatoxin in maize and cottonseed. Toxins 3 (6):678–96. . doi: 10.3390/toxins3060678.
  • Chalivendra, S. C., C. DeRobertis, P.-K. Chang, and K. E. Damann. 2017. Cyclopiazonic acid is a pathogenicity factor for Aspergillus flavus and a promising target for screening germplasm for ear rot resistance. Molecular Plant-Microbe Interactions: MPMI 30 (5):361–73. doi: 10.1094/MPMI-02-17-0026-R.
  • Chang, P.-K., H. K. Abbas, M. A. Weaver, K. C. Ehrlich, L. L. Scharfenstein, and P. J. Cotty. 2012. Identification of genetic defects in the atoxigenic biocontrol strain Aspergillus flavus K49 reveals the presence of a competitive recombinant group in field populations. International Journal of Food Microbiology 154 (3):192–6. doi: 10.1016/j.ijfoodmicro.2012.01.005.
  • Chang, P.-K., B. W. Horn, and J. W. Dorner. 2005. Sequence breakpoints in the aflatoxin biosynthesis gene cluster and flanking regions in nonaflatoxigenic Aspergillus flavus isolates. Fungal Genetics and Biology: FG & B 42 (11):914–23. doi: 10.1016/j.fgb.2005.07.004.
  • Chankhamjon, P., D. Boettger-Schmidt, K. Scherlach, B. Urbansky, G. Lackner, D. Kalb, H. M. Dahse, D. Hoffmeister, and C. Hertweck. 2014. Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion. Angewandte Chemie (International ed. in English) 53 (49):13409–13. doi: 10.1002/anie.201407624.
  • Chauhan, Y. S., J. Tatnell, S. Krosch, J. Karanja, B. Gnonlonfin, I. Wanjuki, J. Wainaina, and J. Harvey. 2015. An improved simulation model to predict pre-harvest aflatoxin risk in maize. Field Crops Research 178:91–9. doi: 10.1016/j.fcr.2015.03.024.
  • Chauhan, Y. S., G. C. Wright, R. C. N. Rachaputi, D. Holzworth, A. Broome, S. Krosch, and M. Robertson. 2010. Application of a model to assess aflatoxin risk in peanuts. Journal of Agricultural Science 148:141–51. doi: 10.1017/S002185961000002X.
  • Chinese Pharmacopeia Commission. 2015. The Pharmacopoeia of People’s Republic of China (Part 1), 247–8. Beijing, China: Press of Chemical Industry.
  • Clutterbuck, A. J. 1996. Parasexual recombination in fungi. Journal of Genetics 75 (3):281–6. doi: 10.1007/BF02966308.
  • Cole, R. J. 1986. Etiology of turkey "X" disease in retrospect: A case for the involvement of cyclopiazonic acid. Mycotoxin Research 2 (1):3–7. doi: 10.1007/BF03191956.
  • Cole, R. J., and P. J. Cotty. 1990. Biocontrol of Aflatoxin production by using biocompetitive agents. From: A Perspective on Aflatoxin in Field Crops and Animal Food Products in the United States, a Symposium, January 23–24, 1990, Washington, DC, ARS-83, 62–6.
  • Cotty, P. J. 1989. Virulence and cultural characteristics of two Aspergillus flavus strains pathogenic on cotton. Phytopathology 79 (7):808–14. doi: 10.1094/Phyto-79-808.
  • Cotty, P. J. 1994. Influence of field application of an atoxigenic strain of Aspergillus flavus on the populations of A. flavus infecting cotton bolls and on the aflatoxin content of cottonseed. Phytopathology 84 (11):1270–7. doi: 10.1094/Phyto-84-1270.
  • De Iongh, H., R. O. Vles, and J. G. Van Pelt. 1964. Investigation of the milk of mammals fed on aflatoxin containing diet. Nature (London) 202:466–7. doi: 10.1038/202466a0.
  • Dhanasekaran, D.,. S. Shanmugapriya, N. Thajuddin, and A. Panneerselvam. 2011. Aflatoxins and aflatoxicosis in human and animals. In Aflatoxins - Biochemistry and molecular biology, ed. R.G. Guevara-González. London: IntechOpen. doi: 10.5772/22717.
  • Dorner, J. W. 2009. Development of biocontrol technology to manage aflatoxin contamination in peanuts. Peanut Science 36 (1):60–7. doi: 10.3146/AT07-002.1.
  • Dorner, J. W., and R. J. Cole. 2002. Effect of application of nontoxigenic strains of Aspergillus flavus and A. parasiticus on subsequent aflatoxin contamination of peanuts in storage. Journal of Stored Products Research 38 (4):329–39. . (01)00035-2 doi: 10.1016/S0022-474X(01)00035-2.
  • Dorner, J. W., R. J. Cole, and P. D. Blankenship. 1992. Use of a biocompetitive agent to control preharvest aflatoxin in drought stressed peanuts. Journal of Food Protection 55 (11):888–92. doi: 10.4315/0362-028X-55.11.888.
  • Dorner, J. W., R. J. Cole, and D. T. Wicklow. 1999. Aflatoxin reduction in corn through field application of competitive fungi. Journal of Food Protection 62 (6):650–6. doi: 10.4315/0362-028X-62.6.650.
  • Dorner, J. W., and M. C. Lamb. 2006. Development and commercial use of afla-Guard(®), an aflatoxin biocontrol agent . Mycotoxin Research 22 (1):33–8. doi: 10.1007/BF02954555.
  • Doster, M. A., P. J. Cotty, and T. J. Michailides. 2014. Evaluation of the atoxigenic Aspergillus flavus strain AF36 in pistachio orchards. Plant Disease 98 (7):948–56. doi: 10.1094/PDIS-10-13-1053-RE.
  • Drott, M. T., B. P. Lazzaro, D. L. Brown, I. Carbone, and M. G. Milgroom. 2017. Balancing selection for aflatoxin in Aspergillus flavus is maintained through interference competition with, and fungivory by insects. Proceedings of the Royal Society B: Biological Sciences 284 (1869):e1869. doi: 10.1098/rspb.2017.2408.
  • Ehrlich, K. C. 2006. Evolution of the aflatoxin gene cluster. Mycotoxin Research 22 (1):9–15. doi: 10.1007/BF02954551.
  • Ehrlich, K. C. 2014. Non-aflatoxigenic Aspergillus flavus to prevent aflatoxin contamination in crops: Advantages and limitations. Frontiers in Microbiology 5:50e50. doi: 10.3389/fmicb.2014.00050.
  • Ehrlich, K. C., and P. J. Cotty. 2004. An isolate of Aspergillus flavus used to reduce aflatoxin contamination in cottonseed has a defective polyketide synthase gene. Applied Microbiology and Biotechnology 65 (4):473–8. doi: 10.1007/s00253-004-1670-y.
  • Fennell, D. I., and J. H. Warcup. 1959. The ascocarps of Aspergillus alliaceus. Mycologia 51 (3):409–15. doi: 10.2307/3756060.
  • Fountain, J. C., P. Bajaj, M. Pandey, S. N. Nayak, L. Yang, V. Kumar, A. S. Jayale, A. Chitikineni, W. Zhuang, B. T. Scully, et al. 2016. Oxidative stress and carbon metabolism influence Aspergillus flavus transcriptome composition and secondary metabolite production. Scientific Reports 6:38747., e38747. doi: 10.1038/srep38747.
  • Fountain, J. C., B. T. Scully, X. Ni, R. C. Kemerait, R. D. Lee, Z. Y. Chen, and B. Guo. 2014. Environmental influences on maize-Aspergillus flavus interactions and aflatoxin production. Frontiers in Microbiology 5:40. doi: 10.3389/fmicb.2014.00040.
  • Frisvad, J. C., V. Hubka, C. N. Ezekiel, S.-B. Hong, A. Nováková, A. J. Chen, M. Arzanlou, T. O. Larsen, F. Sklenář, W. Mahakarnchanakul, et al. 2019. Taxonomy of Aspergillus section Flavi and their production of aflatoxins, ochratoxins and other mycotoxins. Studies in Mycology 93:1–63. doi: 10.1016/j.simyco.2018.06.001.
  • Gao, X., and M. V. Kolomiets. 2009. Host‐derived lipids and oxylipins are crucial signals in modulating mycotoxin production by fungi. Toxin Reviews 28 (2-3):79–88. doi: 10.1080/15569540802420584.
  • Gardner, H. K., S. P. Koltun, F. G. Dollear, and E. T. Rayner. 1971. Inactivation of aflatoxins in peanut and cottonseed meals by ammoniation. Journal of the American Oil Chemists' Society 48 (2):70–3. doi: 10.1007/BF02635688.
  • Gasperini, A. M., A. Rodriguez-Sixtos, C. Verheecke-Vaessen, E. Garcia-Cela, A. Medina, and N. Magan. 2019. Resilience of biocontrol for aflatoxin minimization strategies: Climate change abiotic factors may affect control in non-GM and GM-maize cultivars. Frontiers in Microbiology 10:2525. doi: 10.3389/fmicb.2019.02525.
  • Geiser, D. M., J. W. Dorner, B. W. Horn, and J. W. Taylor. 2000. The phylogenetics of mycotoxin and sclerotium production in Aspergillus flavus and Aspergillus oryzae. Fungal Genetics and Biology: FG & B 31 (3):169–79. doi: 10.1006/fgbi.2000.1215.
  • Geiser, D. M., J. I. Pitt, and J. W. Taylor. 1998. Cryptic speciation and recombination in the aflatoxin-producing fungus Aspergillus flavus. Proceedings of the National Academy of Sciences 95: 388–93. doi: 10.1073/pnas.95.1.388.
  • Gell, R. M., and I. Carbone. 2019. HPLC quantitation of aflatoxin B1 from fungal mycelium culture. Journal of Microbiological Methods 158:14–7. doi: 10.1016/j.mimet.2019.01.008.
  • Gell, R. M., B. W. Horn, and I. Carbone. 2020. Genetic map and heritability of Aspergillus flavus. Fungal Genetics and Biology : FG & B 144:103478. doi: 10.1016/j.fgb.2020.103478.
  • Gilbert, M. K., B. M. Mack, G. A. Payne, and D. Bhatnagar. 2016. Use of functional genomics to assess the climate change impact on Aspergillus flavus and aflatoxin production. World Mycotoxin Journal 9 (5):665–72. doi: 10.3920/WMJ2016.2049.
  • Gilbert, M., A. Medina, B. Mack, M. Lebar, A. Rodríguez, D. Bhatnagar, N. Magan, G. Obrian, and G. Payne. 2017. Carbon dioxide mediates the response to temperature and water activity levels in Aspergillus flavus during infection of maize kernels. Toxins 10 (1):e5. doi: 10.3390/toxins10010005.
  • Gioti, A., J. E. Stajich, and H. Johannesson. 2013. Neurospora and the dead-end hypothesis: genomic consequences of selfing in the model genus. Evolution; International Journal of Organic Evolution 67 (12):3600–16. doi: 10.1111/evo.12206.
  • Golan, J. J., and A. Pringle. 2017. Long-distance dispersal of fungi. Microbiology Spectrum 5:FUNK–0047. doi: http://dx.doi.org/10.1128/microbiolspec.FUNK-0047-2016.
  • Gould, A. B. 2009. Fungi: Plant pathogenic. In Encyclopedia of microbiology (3rd Ed.), ed. M. Schaechter, 457–77. Cambridge, MA: Academic Press:. doi: 10.1016/B978-012373944-5.00347-3.
  • Goto, T., D. T. Wicklow, and Y. Ito. 1996. Aflatoxin and cyclopiazonic acid production by a sclerotium-producing Aspergillus tamarii strain. Applied and Environmental Microbiology 62 (11):4036–8. doi: 10.1128/AEM.62.11.4036-4038.1996.
  • Grandaubert, J., J. Y. Dutheil, and E. H. Stukenbrock. 2019. The genomic determinants of adaptive evolution in a fungal pathogen. Evolution Letters 3 (3):299–312. doi: 10.1101/176727.
  • Greeff-Laubscher, M. R., I. Beukes, G. J. Marais, and K. Jacobs. 2019. Mycotoxin production by three different toxigenic fungi genera on formulated abalone feed and the effect of an aquatic environment on fumonisins. Mycology 11 (2):105–17. doi: 10.1080/21501203.2019.1604575.
  • Grubisha, L. C., and P. J. Cotty. 2015. Genetic analysis of the Aspergillus flavus vegetative compatibility group to which a biological control agent that limits aflatoxin contamination in U.S. crops belongs. Applied and Environmental Microbiology 81 (17):5889–99. doi: 10.1128/AEM.00738-15.
  • Grünwald, N. J., S. E. Everhart, B. J. Knaus, and Z. N. Kamvar. 2017. Best practices for population genetic analyses. Phytopathology 107 (9):1000–10. doi: 10.1094/PHYTO-12-16-0425-RVW.
  • Heissl, A., A. J. Betancourt, P. Hermann, G. Povysil, B. Arbeithuber, A. Futschik, T. Ebner, and I. Tiemann-Boege. 2019. The impact of poly-A microsatellite heterologies in meiotic recombination. Life Science Alliance 2 (2):e201900364. . doi: 10.26508/lsa.201900364.
  • Horn, B. W. 2003. Ecology and population biology of aflatoxigenic fungi in soil. Journal of Toxicology: Toxin Reviews 22 (2-3):351–79. doi: 10.1081/TXR-120024098.
  • Horn, B. W., and J. W. Dorner. 2002. Effect of competition and adverse culture conditions on aflatoxin production by Aspergillus flavus through successive generations. Mycologia 94 (5):741–51. doi: 10.1080/15572536.2003.11833167.
  • Horn, B. W., R. M. Gell, R. Singh, S. B. Sorensen, and I. Carbone. 2016. Sexual reproduction in Aspergillus flavus sclerotia: Acquisition of novel alleles from soil populations and uniparental mitochondrial inheritance. Plos One 11 (1):e0146169. doi: 10.1371/journal.pone.0146169.
  • Horn, B. W., and R. L. Greene. 1995. Vegetative compatibility within populations of Aspergillus flavus, A. parasiticus, and A. tamarii from a peanut field. Mycologia 87 (3):324–32. doi: 10.2307/3760829.
  • Horn, B. W., R. L. Greene, V. S. Sobolev, J. W. Dorner, J. H. Powell, and R. C. Layton. 1996. Association of morphology and mycotoxin production with vegetative compatibility groups in Aspergillus flavus, A. parasiticus, and A. tamarii. Mycologia 88 (4):574–87. doi: 10.2307/3761151.
  • Horn, B. W., G. G. Moore, and I. Carbone. 2009. Sexual reproduction in Aspergillus flavus. Mycologia 101 (3):423–9. doi: 10.3852/09-011.
  • Horn, B. W., J. H. Ramirez-Prado, and I. Carbone. 2009. Sexual reproduction and recombination in the aflatoxin-producing fungus Aspergillus parasiticus. Fungal Genetics and Biology: FG & B 46 (2):169–75. doi: 10.1016/j.fgb.2008.11.004.
  • Horn, B. W., R. B. Sorensen, M. C. Lamb, V. S. Sobolev, R. A. Olarte, C. J. Worthington, and I. Carbone. 2014. Sexual reproduction in Aspergillus flavus sclerotia naturally produced in corn. Phytopathology 104 (1):75–85. doi: 10.1094/PHYTO-05-13-0129-R.
  • Hua, S. S. T., J. L. Baker, and M. Flores-Espiritu. 1999. Interactions of saprophytic yeasts with a nor mutant of Aspergillus flavus. Applied and Environmental Microbiology 65 (6):2738–40. doi: 10.1128/AEM.65.6.2738-2740.1999.
  • Huang, C., A. Jha, R. R. Sweany, C. DeRobertis, and K. E. Damann. Jr. 2011. Intraspecific aflatoxin inhibition in Aspergillus flavus is thigmoregulated, independent of vegetative compatibility group and is strain dependent. PLoS One 6 (8):e23470. doi: 10.1371/journal.pone.0023470.
  • Hyde, K. D., J. Xu, S. Rapior, R. Jeewon, S. Lumyong, A. G. T. Niego, P. D. Abeywickrama, J. V. S. Aluthmuhandiram, R. S. Brahamanage, S. Brooks, et al. 2019. The amazing potential of fungi: 50 ways we can exploit fungi industrially. Fungal Diversity 97 (1):1–136., . doi: 10.1007/s13225-019-00430-9.
  • Islam, M. S., K. A. Callicott, C. Mutegi, R. Bandyopadhyay, and P. J. Cotty. 2018. Aspergillus flavus resident in Kenya: High genetic diversity in an ancient population primarily shaped by clonal reproduction and mutation-driven evolution. Fungal Ecology 35:20–33. doi: 10.1016/j.funeco.2018.05.012.
  • Ito, Y., S. W. Peterson, D. T. Wicklow, and T. Goto. 2001. Aspergillus pseudotamarii, a new aflatoxin producing species in Aspergillus section Flavi. Mycological Research 105 (2):233–9. doi: 10.1017/S0953756200003385.
  • Jaibangyang, S., R. Nasanit, and S. Limtong. 2020. Biological control of aflatoxin-producing Aspergillus flavus by volatile organic compound-producing antagonistic yeasts. BioControl 65 (3):377–86. doi: 10.1007/s10526-020-09996-9.
  • Jørgensen, T. R. 2007. Identification and toxigenic potential of the industrially important fungi, Aspergillus oryzae and Aspergillus sojae. Journal of Food Protection 70 (12):2916–34. doi: 10.4315/0362-028x-70.12.2916.
  • Kagot, V., S. Okoth, M. D. Boevre, and S. D. Saeger. 2019. Biocontrol of Aspergillus and Fusarium mycotoxins in Africa: Benefits and limitations. Toxins 11 (2):109. doi: 10.3390/toxins11020109.
  • Kaminiaris, M. D., M. L. Camardo, D. I. Tsitsigiannis, and P. Battilani. 2020. AFLA-PISTACHIO: Development of a mechanistic model to predict the aflatoxin contamination of pistachio nuts. Toxins 12 (7):e445. doi: 10.3390/toxins12070445.
  • Kifle, M., K. S. Yobo, and M. Laing. 2017. Biocontrol of Aspergillus flavus in groundnut using Trichoderma harzianum strain kd. Journal of Plant Diseases and Protection 124 (1):51–6. 6. doi: 10.1007/s41348-016-0066-4.
  • King, E. D., A. B. Bassi, Jr., D. C. Ross, and B. Druebbisch. 2011. An industry perspective on the use of “atoxigenic” strains of Aspergillus flavus as biological control agents and the significance of cyclopiazonic acid. Toxin Reviews 30 (2-3):33–41. doi: 10.3109/15569543.2011.588818.
  • Kinyungu, S., T. Isakeit, P. S. Ojiambo, and C. P. Woloshuk. 2019. Spread of Aspergillus flavus and aflatoxin accumulation in postharvested maize treated with biocontrol products. Journal of Stored Products Research 84:101519. doi: 10.1016/j.jspr.2019.101519.
  • Klarić, M. S., D. Rašić, and M. Peraica. 2013. Deleterious effects of mycotoxin combinations involving ochratoxin A. Toxins 5 (11):1965–87. doi: 10.3390/toxins5111965.
  • Klich, M. A. 2007. Aspergillus flavus: The major producer of aflatoxin. Molecular Plant Pathology 8 (6):713–22. doi: 10.1111/j.1364-3703.2007.00436.x.
  • Lavkor, I., H. Arioglu, I. Var, and S. Oztemiz. 2019. Biological control of aflatoxigenic fungi on peanut: For the pre-harvest approach. Turkish Journal of Field Crops 24:21–7. doi: 10.17557/tjfc.562634.
  • Leaich, L. L., and K. E. Papa. 1975. Identification of diploids of Aspergillus flavus by the nuclear condition of conidia. Mycologia 67 (3):674–8. doi: 10.1080/00275514.1975.12019793.
  • Lee, S. C., M. Ni, W. Li, C. Shertz, and J. Heitman. 2010. The evolution of sex: A perspective from the fungal kingdom. Microbiology and Molecular Biology Reviews: MMBR 74 (2):298–340. doi: 10.1128/MMBR.00005-10.
  • Leong, Y., A. A. Latiff, N. I. Ahmad, and A. Rosma. 2012. Exposure measurement of aflatoxins and aflatoxin metabolites in human body fluids. A short review. Mycotoxin Research 28 (2):79–87. . doi: 10.1007/s12550-012-0129-8.
  • Leslie, J. F. 1993. Fungal vegetative compatibility. Annual Review of Phytopathology 31:127–50. doi: 10.1146/annurev.py.31.090193.001015.
  • Leslie, J. F., and K. A. Zeller. 1996. Heterokaryon incompatibility in fungi—more than just another way to die. Journal of Genetics 75 (3):415–24. doi: 10.1007/BF02966319.
  • Lewis, M. H., I. Carbone, J. M. Luis, G. A. Payne, K. I. Bowen, A. K. Hagan, R. Kemerait, R. Heiniger, and P. S. Ojiambo. 2019. Biocontrol strains differentially shift the genetic structure of indigenous soil populations of Aspergillus flavus. Frontiers in Microbiology 10:e1738. doi: 10.3389/fmicb.2019.01738.
  • Lightfoot, T. L., and J. M. Yeager. 2008. Pet bird toxicity and related environmental concerns. Veterinary Clinics of North America: Exotic Animals Practice 11:245–6. doi: 10.1016/j.cvex.2008.01.006.
  • Link, J. H. F. 1809. Observationes in ordines plantarum naturales. Dissertatio I. Magazin der Gesellschaft Naturforschenden Freunde Berlin 3:3–42.
  • Loi, M., C. Paciolla, A. F. Logrieco, and G. Mulè. 2020. Plant bioactive compounds in pre- and postharvest management for aflatoxins reduction. Frontiers in Microbiology 11:243. doi: 10.3389/fmicb.2020.00243.
  • Luis, J. M., I. Carbone, G. A. Payne, D. Bhatnagar, J. W. Cary, G. G. Moore, M. D. Lebar, Q. Wei, B. M. Mack, and P. S. Ojiambo. 2020. Characterization of morphological changes within stromata during sexual reproduction in Aspergillus flavus. Mycologia 112 (5):908–20. doi: 10.1080/00275514.2020.1800361.
  • Machida, M. 2002. Progress of Aspergillus oryzae Genomics. In Advances in applied microbiology, ed. A. I. Laskin, J. W. Bennett, and G. M. Gadd, vol. 51, 1st ed., 81–107. doi: 10.1016/S0065-2164(02)51002-9.
  • Magnussen, A., and M. A. Parsi. 2013. Aflatoxins, hepatocellular carcinoma and public health. World Journal of Gastroenterology 19 (10):1508–12. doi: 10.3748/wjg.v19.i10.1508.
  • Mallikarjunaiah, N. H., N. Jayapala, H. Puttaswamy, and N. Siddapura Ramachandrappa. 2017. Characterization of non-aflatoxigenic strains of Aspergillus flavus as potential biocontrol agent for the management of aflatoxin contamination in groundnut. Microbial Pathogenesis 102:21–8. doi: 10.1016/j.micpath.2016.11.007.
  • Malloch, D., and R. F. Cain. 1972. The trichocomataceae: ascomycetes with Aspergillus, Paecilomyces, and Penicillium imperfect states. Canadian Journal of Botany 50 (12):2613–28. doi: 10.1139/b72-335.
  • Mamo, F. T., B. Shang, J. N. Selvaraj, Y. Wang, and Y. Liu. 2018. Isolation and characterization of Aspergillus flavus strains in China. Journal of Microbiology (Seoul, Korea) 56 (2):119–27. doi: 10.1007/s12275-018-7144-1.
  • Mannaa, M., and K. D. Kim. 2016. Microbe-mediated control of mycotoxigenic grain fungi in stored rice with focus on aflatoxin biodegradation and biosynthesis inhibition. Mycobiology 44 (2):67–78. doi: 10.5941/MYCO.2016.44.2.67.
  • Mannaa, M., and K. D. Kim. 2017. Influence of temperature and water activity on deleterious fungi and mycotoxin production during grain storage. Mycobiology 45 (4):240–54. doi: 10.5941/MYCO.2017.45.4.240.
  • Maor, R., and K. Shirasu. 2005. The arms race continues: Battle strategies between plants and fungal pathogens. Current Opinion in Microbiology 8 (4):399–404. doi: 10.1016/j.mib.2005.06.008.
  • Mauro, A., P. Battilani, and P. J. Cotty. 2015. Selection of atoxigenic Aspergillus flavus isolates endemic to Italy for the biocontrol of aflatoxins in maize. BioControl 60 (1):125–34. . doi: 10.1007/s10526-014-9624-5.
  • Mauro, A., E. Garcia-Cela, A. Pietri, P. J. Cotty, and P. Battilani. 2018. Biological control products for aflatoxin prevention in Italy: Commercial field evaluation of atoxigenic Aspergillus flavus active ingredients. Toxins 10 (1):e30. doi: 10.3390/toxins10010030.
  • McAlpin, C. E., and D. T. Wicklow. 2005. Culture media and sources of nitrogen promoting the formation of stromata and ascocarps in Petromyces alliaceus (Aspergillus section Flavi). Canadian Journal of Microbiology 51 (9):765–71. doi: 10.1139/w05-057.
  • Medina, A., M. K. Gilbert, B. M. Mack, G. R. OBrian, A. Rodríguez, D. Bhatnagar, G. Payne, and N. Magan. 2017. Interactions between water activity and temperature on the Aspergillus flavus transcriptome and aflatoxin B1 production. International Journal of Food Microbiology 256:36–44. doi: 10.1016/j.ijfoodmicro.2017.05.020.
  • Medina, A., A. Rodríguez, and N. Magan. 2014. Effect of climate change on Aspergillus flavus and aflatoxin B1 production. Frontiers in Microbiology 5:348e348. doi: 10.3389/fmicb.2014.00348.
  • Medina, A., A. Rodríguez, Y. Sultan, and N. Magan. 2015. Climate change factors and Aspergillus flavus: Effects on gene expression, growth and aflatoxin production. World Mycotoxin Journal 8 (2):171–9. doi: 10.3920/WMJ2014.1726.
  • Molo, M. S., R. W. Heiniger, L. Boerema, and I. Carbone. 2019. Trial summary on the comparison of various non‐aflatoxigenic strains of Aspergillus flavus on mycotoxin levels and yield in maize. Agronomy Journal 111 (2):942–6. doi: 10.2134/agronj2018.07.0473.
  • Monacell, J. T., B. W. Horn, R. Singh, E. A. Stone, and I. Carbone. 2014. Characterization of putative heterokaryon incompatibility loci in Aspergillus flavus and allied species [dissertation], Chapter 4, 53–92. Raleigh, NC: North Carolina State University.
  • Moore, G. G. 2015. Heritability study of eGFP-transformed Aspergillus flavus strains. World Mycotoxin Journal 8 (3):301–10. doi: 10.3920/WMJ2014.1724.
  • Moore, G. G., J. L. Elliott, R. Singh, B. W. Horn, J. W. Dorner, E. A. Stone, S. N. Chulze, G. G. Barros, M. K. Naik, G. C. Wright, et al. 2013. Sexuality generates diversity in the aflatoxin gene cluster: Evidence on a global scale. PLoS Pathogens 9 (8):e1003574., . doi: 10.1371/journal.ppat.1003574.
  • Moore, G. G., M. D. Lebar, and C. H. Carter‐Wientjes. 2019. The role of extrolites secreted by nonaflatoxigenic Aspergillus flavus in biocontrol efficacy. Journal of Applied Microbiology 126 (4):1257–64. doi: 10.1111/jam.14175.
  • Moore, G. G., R. A. Olarte, B. W. Horn, J. L. Elliott, R. Singh, C. J. O'Neal, and I. Carbone. 2017. Global population structure and adaptive evolution of aflatoxin-producing fungi. Ecology and Evolution 7 (21):9179–91. doi: 10.1002/ece3.3464.
  • Moore, G. G., R. Singh, B. W. Horn, and I. Carbone. 2009. Recombination and lineage-specific gene loss in the aflatoxin gene cluster of Aspergillus flavus. Molecular Ecology 18 (23):4870–87. doi: 10.1111/j.1365-294X.2009.04414.x.
  • Moradi, M., M. Rohani, S. R. Fani, M. T. H. Mosavian, C. Probst, and P. Khodaygan. 2020. Biocontrol potential of native yeast strains against Aspergillus flavus and aflatoxin production in pistachio. Food Additives & Contaminants: Part A 37 (11):1963–73. doi: 10.1080/19440049.2020.1811901.
  • Moral, J., M. T. Garcia-Lopez, B. X. Camiletti, R. Jaime, T. J. Michailides, R. Bandyopadhyay, and A. Ortega-Beltran. 2020. Present status and perspective on the future use of aflatoxin biocontrol products. Agronomy 10 (4):e491. doi: 10.3390/agronomy10040491.
  • Mori, N., T. Katayama, R. Saito, K. Iwashita, and J.-I. Maruyama. 2019. Inter-strain expression of sequence-diverse HET domain genes severely inhibits growth of Aspergillus oryzae. Bioscience, Biotechnology, and Biochemistry 83 (8):1557–69. doi: 10.1080/09168451.2019.1580138.
  • Muirhead, C. A., N. L. Glass, and M. Slatkin. 2002. Multilocus self-recognition systems in fungi as a cause of trans-species polymorphism. Genetics 161 (2):633–41.
  • Naranjo‐ortiz, M. A., andT. Gabaldón. 2019. Fungal evolution: diversity, taxonomy and phylogeny of the Fungi. Biological Reviews 94 (6):2101–37. doi:10.1111/brv.12550.
  • Nesci, A. V., R. V. Bluma, and M. G. Etcheverry. 2005. In vitro selection of maize rhizobacteria to study potential biological control of Aspergillus section Flavi and aflatoxin production. European Journal of Plant Pathology 113 (2):159–71. doi: 10.1007/s10658-005-5548-3.
  • Nicolopoulou-Stamati, P., S. Maipas, C. Kotampasi, P. Stamatis, and L. Hens. 2016. Chemical pesticides and human health: The urgent need for a new concept in agriculture. Frontiers in Public Health 4:148. doi: 10.3389/fpubh.2016.00148.
  • Nieuwenhuis, B. P. S., and T. Y. James. 2016. The frequency of sex in fungi. Philosophical Transactions of the Royal Society B: Biological Sciences 371 (1706):e20150540. doi: 10.1098/rstb.2015.0540.
  • O'Gorman, C. M., H. T. Fuller, and P. S. Dyer. 2009. Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus. Nature 457 (7228):471–5. doi: 10.1038/nature07528.
  • Ojiambo, P. S., P. Battilani, J. W. Cary, B. H. Blum, and I. Carbone. 2018. Cultural and genetic approaches to manage aflatoxin contamination: Recent insights provide opportunities for improved control. Phytopathology 108 (9):1024–37. doi: 10.1094/PHYTO-04-18-0134-RVW.
  • Okoth, S. 2016. Improving the evidence base on aflatoxin contamination and exposure in Africa: Strengthening the agriculture-nutrition nexus. CTA Working Paper 16/13. https://pdfs.semanticscholar.org/4b57/815d5d702339f59eaac6d30fa38efa4a8370.pdf
  • Okoth, S., M. De Boevre, A. Vidal, J. D. Di Mavungu, S. Landschoot, M. Kyallo, J. Njuguna, J. Harvey, and S. D. Saeger. 2018. Genetic and toxigenic variability within Aspergillus flavus population isolated from maize in two diverse environments in Kenya. Frontiers in Microbiology 9:57. doi: 10.3389/fmicb.2018.00057.
  • Olarte, R. A., B. W. Horn, J. W. Dorner, J. T. Monacell, R. Singh, E. A. Stone, and I. Carbone. 2012. Effect of sexual recombination on population diversity in aflatoxin production by Aspergillus flavus and evidence for cryptic heterokaryosis. Molecular Ecology 21 (6):1453–76. doi: 10.1111/j.1365-294X.2011.05398.x.
  • Olarte, R. A., C. J. Worthington, B. W. Horn, G. G. Moore, R. Singh, J. T. Monacell, J. W. Dorner, E. A. Stone, D.-Y. Xie, and I. Carbone. 2015. Enhanced diversity and aflatoxigenicity in interspecific hybrids of Aspergillus flavus and Aspergillus parasiticus. Molecular Ecology 24 (8):1889–909. doi: 10.1111/mec.13153.
  • Ortega-Beltran, A., and P. J. Cotty. 2018. Frequent shifts in Aspergillus flavus populations associated with maize production in Sonora, Mexico. Phytopathology 108 (3):412–20. doi: 10.1094/PHYTO-08-17-0281-R.
  • Ortega-Beltran, A., J. Moral, A. Picot, R. D. Puckett, P. J. Cotty, and T. J. Michailides. 2019. Atoxigenic Aspergillus flavus isolates endemic to almond, fig, and pistachio orchards in California with potential to reduce aflatoxin contamination in these crops. Plant Disease 103 (5):905–12. doi: 10.1094/PDIS-08-18-1333-RE.
  • Ouko, A., S. Okoth, N. Amugune, and V. Joutsjoki. 2018. Characterization of mating type genes in Aspergillus flavus populations from two locations in Kenya. Advances in Agriculture 2018:1–6. doi: 10.1155/2018/3095096.
  • Palumbo, J. D., J. L. Baker, and N. E. Mahoney. 2006. Isolation of bacterial antagonists of Aspergillus flavus from almonds. Microbial Ecology 52 (1):45–52. doi: 10.1007/s00248-006-9096-y.
  • Papa, K. E. 1973. The parasexual cycle in Aspergillus flavus. Mycologia 65 (5):1201–5. doi: 10.2307/3758299.
  • Papa, K. E. 1976. Linkage groups in Aspergillus flavus. Mycologia 68 (1):159–65. doi: 10.2307/3758906.
  • Papa, K. E. 1986. Heterokaryon incompatibility in Aspergillus flavus. Mycologia 78 (1):98–101. doi: 10.2307/3793383.
  • Pasqualotto, A. C., and D. W. Denning. 2008. An aspergilloma caused by Aspergillus flavus. Medical Mycology 46 (3):275–8. doi: 10.1080/13693780701624639.
  • Phillips, T. D., E. Afriyie-Gyawu, J. Williams, H. Huebner, N.-A. Ankrah, D. Ofori-Adjei, P. Jolly, N. Johnson, J. Taylor, A. Marroquin-Cardona, et al. 2008. Reducing human exposure to aflatoxin through the use of clay: A review. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 25 (2):134–45., . doi: 10.1080/02652030701567467.
  • Pitt, J. I. 2019. The pros and cons of using biocontrol by competitive exclusion as a means for reducing aflatoxin in maize in Africa. World Mycotoxin Journal 12 (2):103–12. doi: 10.3920/WMJ2018.2410.
  • Pitt, J. I., and A. D. Hocking. 2006. Mycotoxins in Australia: Biocontrol of aflatoxin in peanuts. Mycopathologia 162 (3):233–43. doi: 10.1007/s11046-006-0059-0.
  • Pitt, J. I., and J. W. Taylor. 2014. Aspergillus, its sexual states and the new International Code of Nomenclature. Mycologia 106 (5):1051–62. doi: 10.3852/14-060.
  • Pitt, J. I., C. P. Wild, W. Gelderblom, J. Miller, R. T. Riley, F. Wu, and R. A. Bann. 2012. Improving public health through mycotoxin control. Lyon, France: International Agency for Research on Cancer. Publication No. 158. 162. p.
  • Rajasekaran, K., J. W. Cary, and T. E. Cleveland. 2006. Prevention of preharvest aflatoxin contamination through genetic engineering of crops. Mycotoxin Research 22 (2):118–24. doi: 10.1007/BF02956775.
  • Ramirez-Prado, J. H., G. G. Moore, B. W. Horn, and I. Carbone. 2008. Characterization and population analysis of the mating-type genes in Aspergillus flavus and Aspergillus parasiticus. Fungal Genetics and Biology 45 (9):1292–9. doi: 10.1016/j.fgb.2008.06.007.
  • Raper, K. B., D. I. Fennell, and H. D. Tresner. 1953. The ascosporic stage of Aspergillus citrisporus and related forms. Mycologia 45 (5):671–92. doi: 10.1080/00275514.1953.12024307.
  • Rastogi, S., R. K. Dogra, S. K. Khanna, and M. Das. 2006. Skin tumorigenic potential of aflatoxin B1 in mice. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 44 (5):670–7. doi: 10.1016/j.fct.2005.09.008.
  • Read, N. 2007. Environmental sensing and the filamentous fungal lifestyle. In Fungi in the environment, ed. G. Gadd, S. Watkinson and P. Dyer, 38–57. British Mycological Society Symposia, Cambridge: Cambridge University Press. doi: 10.1017/CBO9780511541797.004.
  • Rédou, V., M. Vallet, L. Meslet-Cladière, A. Kumar, K.-L. Pang, Y.-F. Pouchus, G. Barbier, O. Grovel, S. Bertrand, S. Prado, et al. 2016. Marine fungi. In The marine microbiome, ed. L. Stal and M. Cretoiu, 99–153. Switzerland: Springer, Cham. doi: 10.1007/978-3-319-33000-6.
  • Regnault-Roger, C. 2012. Trends for Commercialization of biocontrol agent (biopesticide) products. In Plant defence: Biological control, ed. J.M. Mérillon and K.G. Ramawat, vol. 12, 139–60. Dordrecht: Springer. doi: 10.1007/978-94-007-1933-0_6.
  • Reis, T. A., T. D. Oliveira, P. Zorzete, P. Faria, and B. Corrêa. 2020. A non-toxigenic Aspergillus flavus strain prevents the spreading of Fusarium verticillioides and fumonisins in maize. Toxicon: Official Journal of the International Society on Toxinology 181:6–8. doi: 10.1016/j.toxicon.2020.04.091.
  • Ren, X., Q. Zhang, W. Zhang, J. Mao, and P. Li. 2020. Control of aflatoxigenic molds by antagonistic microorganisms: Inhibitory behaviors, bioactive compounds, related mechanisms, and influencing factors. Toxins 12 (1):e24. doi: 10.3390/toxins12010024.
  • Reverberi, M., M. Punelli, C. A. Smith, S. Zjalic, M. Scarpari, V. Scala, G. Cardinali, N. Aspite, F. Pinzari, G. A. Payne, et al. 2012. How peroxisomes affect aflatoxin biosynthesis in Aspergillus flavus. Plos One 7 (10):e48097. doi: 10.1371/journal.pone.0048097.
  • Richard, J. L. 2008. Discovery of aflatoxins and significant historical features. Toxin Reviews 27 (3-4):171–201. doi: 10.1080/15569540802462040.
  • Riley, R. T., B. W. Kemppainen, and W. P. Norred. 1985. Penetration of aflatoxins through isolated human epidermis. Journal of Toxicology and Environmental Health 15 (6):769–77. doi: 10.1080/15287398509530703.
  • Rokas, A., G. A. Payne, N. D. Fedorova, S. E. Baker, M. Machida, J. Yu, D. R. Georgianna, R. A. Dean, D. Bhatnagar, T. E. Cleveland, et al. 2007. What can comparative genomics tell us about species concepts in the genus Aspergillus? Studies in Mycology 59:11–7. doi: 10.3114/sim.2007.59.02.
  • Rushing, B. R., and M. I. Selim. 2019. Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 124:81–100. doi: 10.1016/j.fct.2018.11.047.
  • Savić, Z., T. Dudaš, M. Loc, M. Grahovac, D. Budakov, I. Jajić, S. Krstović, T. Barošević, R. Krska, M. Sulyok, et al. 2020. Biological control of aflatoxin in maize grown in Serbia. Toxins 12 (3):e162. doi: 10.3390/toxins12030162.
  • Schaechter, M. 1999. Pier Antonio Micheli, the father of modern mycology: A paean. McIlvainea 14 (1)
  • Scheidegger, K. A., and G. A. Payne. 2003. Unlocking the secrets behind secondary metabolism: A review of Aspergillus flavus from pathogenicity to functional genomics. Journal of Toxicology: Toxin Reviews 22 (2-3):423–59. doi: 10.1081/TXR-120024100.
  • Schmale, I. I. I., and D. G. Munkvold. 2009. Mycotoxins in crops: A threat to human and domestic animal health. Proceedings of the American Phytopathological Society. Minnesota: APS Press. doi: 10.1094/PHI-I-2009-0715-01.
  • Schoustra, S.,. H. D. Rundle, R. Dali, and R. Kassen. 2010. Fitness-associated sexual reproduction in a filamentous fungus. Current Biology: CB 20 (15):1350–5. doi: 10.1016/j.cub.2010.05.060.
  • Seetha, A., W. Munthali, H. W. Msere, E. Swai, Y. Muzanila, E. Sichone, T. W. Tsusaka, A. Rathore, and P. Okori. 2017. Occurrence of aflatoxins and its management in diverse cropping systems of central Tanzania. Mycotoxin Research 33 (4):323–31. doi: 10.1007/s12550-017-0286-x.
  • Senghor, L. A., A. Ortega-Beltran, J. Atehnkeng, K. A. Callicott, P. J. Cotty, and R. Bandyopadhyay. 2020. The atoxigenic biocontrol product Aflasafe SN01 is a valuable tool to mitigate aflatoxin contamination of both maize and groundnut cultivated in Senegal. Plant Disease 104 (2):510–20. doi: 10.1094/PDIS-03-19-0575-RE.
  • Shakeel, Q., A. Lyu, J. Zhang, M. Wu, G. Li, T. Hsiang, and L. Yang. 2018. Biocontrol of Aspergillus flavus on peanut kernels using Streptomyces yanglinensis 3-10. Frontiers in Microbiology 9:1049e1049. doi: 10.3389/fmicb.2018.01049.
  • Shenge, K. C., B. N. Adhikari, A. Akande, K. A. Callicott, J. Atehnkeng, A. Ortega-Beltran, P. L. Kumar, R. Bandyopadhyay, and P. J. Cotty. 2019. Monitoring Aspergillus flavus genotypes in a multi-genotype aflatoxin biocontrol product with quantitative pyrosequencing. Frontiers in Microbiology 10:e2529. doi: 10.3389/fmicb.2019.02529.
  • Shenge, K. C., H. L. Mehl, and P. J. Cotty. 2017. Interactions among active ingredients of a multi-isolate aflatoxin biocontrol product. Phytopathology 107:12S, S5. doi: 10.1094/PHYTO-107-12-S5.1.
  • Sobral, M., M. A. Faria, S. C. Cunha, and I. Ferreira. 2018. Toxicological interactions between mycotoxins from ubiquitous fungi: Impact on hepatic and intestinal human epithelial cells. Chemosphere 202:538–48. doi: 10.1016/j.chemosphere.2018.03.122.
  • Soni, P., S. S. Gangurde, A. Ortega-Beltran, R. Kumar, S. Parmar, H. K. Sudini, Y. Lei, X. Ni, D. Huai, J. C. Fountain, et al. 2020. Functional biology and molecular mechanisms of host-pathogen interactions for aflatoxin contamination in groundnut (Arachis hypogaea L.) and maize (Zea mays L.). Frontiers in Microbiology 11:e227. doi: 10.3389/fmicb.2020.00227.
  • Stapley, J., P. Feulner, S. E. Johnston, A. W. Santure, and C. M. Smadja. 2017. Recombination: The good, the bad and the variable. Philosophical Transactions of the Royal Society B: Biological Sciences 372 (1736):e20170279. doi: 10.1098/rstb.2017.0279.
  • Stevens, A., C. Saunders, J. Spence, and A. Newham. 1960. Investigations into “diseases” of turkey poults. Veterinary Record 72:627–8.
  • Sweany, R. R., and K. E. Damann. Jr 2019. Influence of neighboring clonal-colonies on aflatoxin production by Aspergillus flavus. Frontiers in Microbiology 10:3038. doi: 10.3389/fmicb.2019.03038.
  • Sweany, R. R., K. E. Damann, Jr., and M. D. Kaller. 2011. Comparison of soil and corn kernel Aspergillus flavus populations: Evidence for niche specialization. Phytopathology 101 (8):952–9. doi: 10.1094/PHYTO-09-10-0243.
  • Swilaiman, S. S., C. M. O'Gorman, S. A. Balajee, and P. S. Dyer. 2013. Discovery of a sexual cycle in Aspergillus lentulus, a close relative of A. fumigatus. Eukaryotic cell 12 (7):962–9. doi: 10.1128/EC.00040-13.
  • Taylor, J. W. 2011. One Fungus = One Name: DNA and fungal nomenclature twenty years after PCR. IMA Fungus 2 (2):113–20. doi: 10.5598/imafungus.2011.02.02.01.
  • Taylor, J. W., M. Göker, and J. I. Pitt. 2016. Choosing one name for pleomorphic fungi: The example of Aspergillus versus Eurotium, Neosartorya and Emericella. Taxon 65 (3):593–601. doi: 10.12705/653.10.
  • Taylor, J. W., C. Hann-Soden, S. Branco, I. Sylvain, and C. E. Ellison. 2015. Clonal reproduction in fungi. Proceedings of the National Academy of Sciences of the United States of America 112 (29):8901–8. doi: 10.1073/pnas.1503159112.
  • Tran-Dinh, N., J. I. Pitt, and P. J. Markwell. 2014. Selection of non-toxigenic strains of Aspergillus flavus for biocontrol of aflatoxins in maize in Thailand. Biocontrol Science and Technology 24 (6):652–61. doi: 10.1080/09583157.2014.888398.
  • Tsui, C. K.-M., S. DiGuistini, Y. Wang, N. Feau, B. Dhillon, J. Bohlmann, and R. C. Hamelin. 2013. Unequal recombination and evolution of the mating-type (MAT) loci in the pathogenic fungus Grosmannia clavigera and relatives. G3 (Bethesda, Md.) 3 (3):465–80. doi: 10.1534/g3.112.004986.
  • Tsykun, T.,. C. Rellstab, C. Dutech, G. Sipos, and S. Prospero. 2017. Comparative assessment of SSR and SNP markers for inferring the population genetic structure of the common fungus Armillaria cepistipes. Heredity 119 (5):371–80. doi: 10.1038/hdy.2017.48.
  • Turland, N. J., J. H. Wiersema, F. R. Barrie, W. Greuter, D. L. Hawksworth, P. S. Herendeen, S. Knapp, W.-H. Kusber, D.-Z. Li, K. Marhold (eds.), et al. 2018. International Code of Nomenclature for algae, fungi, and plants (Shenzhen Code) adopted by the Nineteenth International Botanical Congress Shenzhen, China. July 2017. Regnum Vegetabile 159. Glashütten: Koeltz Botanical Books. doi: 10.12705/Code.2018.
  • Udomkun, P., A. N. Wiredu, M. Nagle, J. Müller, B. Vanlauwe, and R. Bandyopadhyay. 2017. Innovative technologies to manage aflatoxins in foods and feeds and the profitability of application - A review. Food Control 76:127–38. doi: 10.1016/j.foodcont.2017.01.008.
  • Uka, V., G. G. Moore, N. Arroyo-Manzanares, D. Nebija, S. D. Saeger, and J. D. D. Mavungu. 2017. Unravelling the diversity of the cyclopiazonic acid family of mycotoxins in Aspergillus flavus by UHPLC Triple-TOF HRMS. Toxins 9 (1):35. doi: 10.3390/toxins9010035.
  • Uka, V., G. G. Moore, N. Arroyo-Manzanares, D. Nebija, S. D. Saeger, and J. D. D. Mavungu. 2019. Secondary metabolite dereplication and phylogenetic analysis identify various emerging mycotoxins and reveal the high intra-species diversity in Aspergillus flavus. Frontiers in Microbiology 10:667. doi: 10.3389/fmicb.2019.00667.
  • Unnevehr, L.J., and D. Grace. 2013. Tackling aflatoxins: An overview of challenges and solutions, In Aflatoxins: Finding solutions for improved food safety, ed. L.J. Unnevehr and D. Grace. 2020 vision briefs 20(1), International Food Policy Research Institute (IFPRI).
  • USEPA. 2003. Conditional biopesticide registration action document Aspergillus flavus AF36. Accessed September 23, 2020. https://www3.epa.gov/pesticides/chem_search/ppls/071693-00001-20030624.pdf
  • USEPA. 2004a. Conditional biopesticide registration action document for Afla-Guard. Accessed September 23, 2020. https://www3.epa.gov/pesticides/chem_search/ppls/075624-00002-20040528.pdf
  • USEPA. 2004b. Biopesticide Registration Action Document for NRRL 21882. Accessed September 23, 2020. https://www3.epa.gov/pesticides/chem_search/reg_actions/registration/decision_PC-006500_24-Mar-04.pdf
  • USEPA. 2015. Request for a Temporary Exemption from the Requirements of a Tolerance Aspergillus flavus strains TC16F, TC35C, TC38B, and TC46G on Corn; FourSureTM. Accessed September 23, 2020. https://downloads.regulations.gov/EPA-HQ-OPP-2015-0742-0005/content.pdf
  • USEPA. 2017. Unconditional Biopesticide Registration Action Document for AF36 Prevail. Accessed September 23, 2020. https://www3.epa.gov/pesticides/chem_search/ppls/071693-00002-20170322.pdf
  • Usher, J. 2019. The mechanisms of mating in pathogenic fungi—a plastic trait. Genes 10 (10):e831. doi: 10.3390/genes10100831.
  • Vaamonde, G., A. Patriarca, and V. E. F. Pinto. 2006. Effect of water activity and temperature on production of aflatoxin and cyclopiazonic acid by Aspergillus flavus in peanuts. In Proceedings of the Fifth International Workshop on Food Mycology, ed. A.D. Hocking, J.I. Pitt, R.A. Samson, and U. Thrane, 571: 225–35. doi: 10.1007/0-387-28391-9_15.
  • Valdes, J. J., J. E. Cameron, and R. J. Cole. 1985. Aflatrem: A tremorgenic mycotoxin with acute neurotoxic effects. Environ Health Perspect 62:459–63. doi: 10.1289/ehp.8562459.
  • Van Der Zijden, A. S. M., W. A. A. B. Koelensmid, J. Boldingh, C. B. Barrett, W. O. Ord, and J. Philp. 1962. Aspergillus flavus and turkey x disease: Isolation in crystalline form of a toxin responsible for turkey x disease. Nature 195 (4846):1060–2. doi: 10.1038/1951060a0.
  • Varga, J., B. Tóth, É. Kevei, A. Palágyi, and Z. Kozakiewicz. 2000. Analysis of genetic variability within the genus Petromyces. Antonie Van Leeuwenhoek 77 (1):83–9. doi: 10.1023/A:1002475816014.
  • Wada, R., J. Maruyama, H. Yamaguchi, N. Yamamoto, Y. Wagu, M. Paoletti, D. B. Archer, P. S. Dyer, and K. Kitamoto. 2012. Presence and functionality of mating type genes in the supposedly asexual filamentous fungus Aspergillus oryzae. Applied and Environmental Microbiology 78 (8):2819–29. doi: 10.1128/AEM.07034-11.
  • Weaver, M. A., and H. K. Abbas. 2019. Field displacement of aflatoxigenic Aspergillus flavus strains through repeated biological control applications. Frontiers in Microbiology 10:1788e1788. doi: 10.3389/fmicb.2019.01788.
  • Weindling, R. 1932. Trichoderma lignorum as a parasite of other soil fungi. Phytopathology 22:837–45.
  • Widiastuti, R., Maryam, R. B. J., Blaney Salfina, and D. R. Stoltz. 1988. Cyclopiazonic acid in combination with aflatoxins, zearalenone and ochratoxin A in Indonesian corn. Mycopathologia 104:153–6. doi: 10.1007/BF00437430.
  • Wik, L., M. Karlsson, and H. Johannesson. 2008. The evolutionary trajectory of the mating-type (mat) genes in Neurospora relates to reproductive behavior of taxa. BMC Evolutionary Biology 8:109. doi: 10.1186/1471-2148-8-109.
  • Yabe, K., N. Chihaya, H. Hatabayashi, M. Kito, S. Hoshino, H. Zeng, J. Cai, and H. Nakajima. 2012. Production of M-/GM-group aflatoxins catalyzed by the OrdA enzyme in aflatoxin biosynthesis. Fungal Genet Biol 49 (9):744–54. doi: 10.1016/j.fgb.2012.06.011.
  • Yu, J., D. Bhatnagar, and T. E. Cleveland. 2004. Completed sequence of aflatoxin pathway gene cluster in Aspergillus parasiticus. FEBS Letters 564 (1-2):126–30. doi: 10.1016/S0014-5793(04)00327-8.
  • Yu, J., P.-K. Chang, K. C. Ehrlich, J. W. Cary, D. Bhatnagar, T. E. Cleveland, G. A. Payne, J. E. Linz, C. P. Woloshuk, and J. W. Bennett. 2004. Clustered pathway genes in aflatoxin biosynthesis. Applied and Environmental Microbiology 70 (3):1253–62. doi: 10.1128/aem.70.3.1253-1262.2004.