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The impact of exercise training versus caloric restriction on inflammation markers: a systemic review and meta-analysis

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  • Anty, R., S. Bekri, N. Luciani, M.-C. Saint-Paul, M. Dahman, A. Iannelli, I. B. Amor, A. Staccini-Myx, P.-M. Huet, J. Gugenheim, et al. 2006. The inflammatory C-reactive protein is increased in both liver and adipose tissue in severely obese patients independently from metabolic syndrome, type 2 diabetes, and NASH. The American Journal of Gastroenterology 101 (8):1824–33., doi: 10.1111/j.1572-0241.2006.00724.x.
  • Auerbach, P., P. Nordby, L. Q. Bendtsen, J. L. Mehlsen, S. K. Basnet, H. Vestergaard, T. Ploug, and B. Stallknecht. 2013. Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 305 (5):R490–8. doi: 10.1152/ajpregu.00575.2012.
  • Bian, F., X. Yang, F. Zhou, P.-H. Wu, S. Xing, G. Xu, W. Li, J. Chi, C. Ouyang, Y. Zhang, et al. 2014. C-reactive protein promotes atherosclerosis by increasing LDL transcytosis across endothelial cells. British Journal of Pharmacology 171 (10):2671–84., doi: 10.1111/bph.12616.
  • Blüher, M. 2014. Adipokines - Removing road blocks to obesity and diabetes therapy. Molecular Metabolism 3 (3):230–40. doi: 10.1016/j.molmet.2014.01.005.
  • Bouchonville, M., R. Armamento-Villareal, K. Shah, N. Napoli, D. R. Sinacore, C. Qualls, and D. T. Villareal. 2014. Weight loss, exercise or both and cardiometabolic risk factors in obese older adults: Results of a randomized controlled trial. International Journal of Obesity (2005) 38 (3):423–31. doi: 10.1038/ijo.2013.122.
  • Boutens, L., G. J. Hooiveld, S. Dhingra, R. A. Cramer, M. G. Netea, and R. Stienstra. 2018. Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses. Diabetologia 61 (4):942–53. doi: 10.1007/s00125-017-4526-6.
  • Brochu, M., M. F. Malita, V. Messier, E. ́. Doucet, I. Strychar, J.-M. Lavoie, D. Prud'homme, and R. Rabasa-Lhoret. 2009. Resistance training does not contribute to improving the metabolic profile after a 6-month weight loss program in overweight and obese postmenopausal women. The Journal of Clinical Endocrinology & Metabolism 94 (9):3226–33. doi: 10.1210/jc.2008-2706.
  • Bruun, J. M., J. W. Helge, B. Richelsen, and B. Stallknecht. 2006. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. American Journal of Physiology-Endocrinology and Metabolism 290 (5):E961–7. doi: 10.1152/ajpendo.00506.2005.
  • Calabro, P., D. W. Chang, J. T. Willerson, and E. T. H. Yeh. 2005. Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: Linking obesity to vascular inflammation. Journal of the American College of Cardiology 46 (6):1112–3.
  • Castell, J. V., M. J. Gómez-Lechón, M. David, R. Fabra, R. Trullenque, and P. C. Heinrich. 1990. Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6. Hepatology (Baltimore, Md.) 12 (5):1179–86. doi: 10.1002/hep.1840120517.
  • Chait, A., and L. J. den Hartigh. 2020. Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease. Frontiers in Cardiovascular Medicine 7:22. doi: 10.3389/fcvm.2020.00022.
  • Cho, A.-R., J.-Y. Moon, S. Kim, K.-Y. An, M. Oh, J. Y. Jeon, D.-H. Jung, M. H. Choi, and J.-W. Lee. 2019. Effects of alternate day fasting and exercise on cholesterol metabolism in overweight or obese adults: A pilot randomized controlled trial. Metabolism 93:52–60. doi: 10.1016/j.metabol.2019.01.002.
  • Christiansen, T., S. K. Paulsen, J. M. Bruun, S. B. Pedersen, and B. Richelsen. 2010. Exercise training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects: A 12-week randomized intervention study. American Journal of Physiology-Endocrinology and Metabolism 298 (4):E824–31. doi: 10.1152/ajpendo.00574.2009.
  • Collao, N., I. Rada, M. Francaux, L. Deldicque, and H. Zbinden-Foncea. 2020. Anti-inflammatory effect of exercise mediated by toll-like receptor regulation in innate immune cells - A review. International Reviews of Immunology 39 (2):39–52. doi: 10.1080/08830185.2019.1682569.
  • Collins, S., and R. S. Surwit. 2001. The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. Recent Progress in Hormone Research 56:309–28. doi: 10.1210/rp.56.1.309.
  • Cooper, J. N., M. L. Columbus, K. J. Shields, J. Asubonteng, M. L. Meyer, K. Sutton-Tyrrell, B. H. Goodpaster, J. P. DeLany, J. M. Jakicic, E. Barinas-Mitchell, et al. 2012. Effects of an intensive behavioral weight loss intervention consisting of caloric restriction with or without physical activity on common carotid artery remodeling in severely obese adults. Metabolism 61 (11):1589–97. doi: 10.1016/j.metabol.2012.04.012.
  • Costigan, S. A., N. Eather, R. C. Plotnikoff, D. R. Taaffe, and D. R. Lubans. 2015. High-intensity interval training for improving health-related fitness in adolescents: A systematic review and meta-analysis. British Journal of Sports Medicine 49 (19):1253–61. doi: 10.1136/bjsports-2014-094490.
  • Crampes, F., M. Beauville, D. Riviere, and M. Garrigues. 1986. Effect of physical training in humans on the response of isolated fat cells to epinephrine. Journal of Applied Physiology (Bethesda, Md.: 1985) 61 (1):25–9. doi: 10.1152/jappl.1986.61.1.25.
  • Dandona, P., A. Aljada, and A. Bandyopadhyay. 2004. Inflammation: The link between insulin resistance, obesity and diabetes. Trends in Immunology 25 (1):4–7. doi: 10.1016/j.it.2003.10.013.
  • de Mello, V. D. F., M. Lankinen, U. Schwab, M. Kolehmainen, S. Lehto, T. Seppänen-Laakso, M. Orešič, L. Pulkkinen, M. Uusitupa, A. T. Erkkilä, et al. 2009. Link between plasma ceramides, inflammation and insulin resistance: Association with serum IL-6 concentration in patients with coronary heart disease. Diabetologia 52 (12):2612–5., doi: 10.1007/s00125-009-1482-9.
  • Dietrich, M., and I. Jialal. 2005. The effect of weight loss on a stable biomarker of inflammation, C-reactive protein. Nutrition Reviews 63 (1):22–8. doi: 10.1111/j.1753-4887.2005.tb00107.x.
  • Donath, M. Y. 2014. Targeting inflammation in the treatment of type 2 diabetes: Time to start. Nature Reviews. Drug Discovery 13 (6):465–76. doi: 10.1038/nrd4275.
  • Egger, M., G. Davey Smith, M. Schneider, and C. Minder. 1997. Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical Research ed.) 315 (7109):629–34. doi: 10.1136/bmj.315.7109.629.
  • Fantuzzi, G. 2005. Adipose tissue, adipokines, and inflammation. The Journal of Allergy and Clinical Immunology 115 (5):911–9. doi: 10.1016/j.jaci.2005.02.023.
  • Fayh, A. P. T., A. L. Lopes, P. R. Fernandes, A. Reischak-Oliveira, and R. Friedman. 2013. Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: A randomised clinical trial. The British Journal of Nutrition 110 (3):486–92. doi: 10.1017/S0007114512005442.
  • Fedewa, M. V., E. D. Hathaway, and C. L. Ward-Ritacco. 2017. Effect of exercise training on C reactive protein: A systematic review and meta-analysis of randomised and non-randomised controlled trials. British Journal of Sports Medicine 51 (8):670–6. doi: 10.1136/bjsports-2016-095999.
  • Fisher, G., T. C. Hyatt, G. R. Hunter, R. A. Oster, R. A. Desmond, and B. A. Gower. 2011. Effect of diet with and without exercise training on markers of inflammation and fat distribution in overweight women. Obesity 19 (6):1131–6. doi: 10.1038/oby.2010.310.
  • Forouhi, N., N. Sattar, and P. McKeigue. 2001. Relation of C-reactive protein to body fat distribution and features of the metabolic syndrome in Europeans and South Asians. International Journal of Obesity 25 (9):1327–31. doi: 10.1038/sj.ijo.0801723.
  • Freitas, P. D., P. G. Ferreira, A. G. Silva, R. Stelmach, R. M. Carvalho-Pinto, F. L. A. Fernandes, M. C. Mancini, M. N. Sato, M. A. Martins, C. R. F. Carvalho, et al. 2017. The role of exercise in a weight-loss program on clinical control in obese adults with asthma. American Journal of Respiratory and Critical Care Medicine 195 (1):32–42., doi: 10.1164/rccm.201603-0446OC.
  • Galedari, M., M. Azarbayjani, and M. Peeri. 2017. Effects of type of exercise along with caloric restriction on plasma apelin 36 and HOMA-IR in overweight men. Science & Sports 32 (4):e137–45. doi: 10.1016/j.scispo.2016.12.002.
  • García-Hermoso, A., R. J. M. Ceballos-Ceballos, C. E. Poblete-Aro, A. C. Hackney, J. Mota, and R. Ramírez-Vélez. 2017. Exercise, adipokines and pediatric obesity: A meta-analysis of randomized controlled trials. International Journal of Obesity (2005) 41 (4):475–82. doi: 10.1038/ijo.2016.230.
  • García-Unciti, M., M. Izquierdo, F. Idoate, E. Gorostiaga, A. Grijalba, F. Ortega-Delgado, C. Martínez-Labari, J. M. Moreno-Navarrete, L. Forga, J. M. Fernández-Real, et al. 2012. Weight-loss diet alone or combined with progressive resistance training induces changes in association between the cardiometabolic risk profile and abdominal fat depots. Annals of Nutrition & Metabolism 61 (4):296–304. doi: 10.1159/000342467.
  • Giannopoulou, I., B. Fernhall, R. Carhart, R. S. Weinstock, T. Baynard, A. Figueroa, and J. A. Kanaley. 2005. Effects of diet and/or exercise on the adipocytokine and inflammatory cytokine levels of postmenopausal women with type 2 diabetes. Metabolism 54 (7):866–75. doi: 10.1016/j.metabol.2005.01.033.
  • Gil-Campos, M., R. Cañete, and A. Gil. 2004. Adiponectin, the missing link in insulin resistance and obesity. Clinical Nutrition (Edinburgh, Scotland) 23 (5):963–74. doi: 10.1016/j.clnu.2004.04.010.
  • Gleeson, M., N. C. Bishop, D. J. Stensel, M. R. Lindley, S. S. Mastana, and M. A. Nimmo. 2011. The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease. Nature Reviews. Immunology 11 (9):607–15. doi: 10.1038/nri3041.
  • Guzik, T., D. Mangalat, and R. Korbut. 2006. Adipocytokines novel link between inflammation. Journal of Physiology and Pharmacology 4:505–28.
  • Hammonds, T. L., E. C. Gathright, C. M. Goldstein, M. S. Penn, and J. W. Hughes. 2016. Effects of exercise on c-reactive protein in healthy patients and in patients with heart disease: A meta-analysis. Heart & Lung 45 (3):273–82. doi: 10.1016/j.hrtlng.2016.01.009.
  • Hayashino, Y., J. L. Jackson, T. Hirata, N. Fukumori, F. Nakamura, S. Fukuhara, S. Tsujii, and H. Ishii. 2014. Effects of exercise on C-reactive protein, inflammatory cytokine and adipokine in patients with type 2 diabetes: A meta-analysis of randomized controlled trials. Metabolism: clinical and Experimental 63 (3):431–40. doi: 10.1016/j.metabol.2013.08.018.
  • Higgins, J. P., J. Thomas, J. Chandler, M. Cumpston, T. Li, M. J. Page, and V. A. Welch, eds. 2019. Cochrane handbook for systematic reviews of interventions. Chichester, UK: John Wiley & Sons.
  • Hozo, S. P., B. Djulbegovic, and I. Hozo. 2005. Estimating the mean and variance from the median, range, and the size of a sample. BMC Medical Research Methodology 5 (1):13. doi: 10.1186/1471-2288-5-13.
  • Ismail, I., S. E. Keating, M. K. Baker, and N. A. Johnson. 2012. A systematic review and meta‐analysis of the effect of aerobic vs. resistance exercise training on visceral fat. Obesity Reviews 13 (1):68–91. doi: 10.1111/j.1467-789X.2011.00931.x.
  • Khoo, J., S. Dhamodaran, D.-D. Chen, S.-Y. Yap, R. Y.-T. Chen, and R. H.-H. Tian. 2015. Exercise-induced weight loss is more effective than dieting for improving adipokine profile, insulin resistance, and inflammation in obese men. International Journal of Sport Nutrition and Exercise Metabolism 25 (6):566–75. doi: 10.1123/ijsnem.2015-0025.
  • Lakhdar, N., M. Denguezli, M. Zaouali, A. Zbidi, Z. Tabka, and A. Bouassida. 2013. Diet and diet combined with chronic aerobic exercise decreases body fat mass and alters plasma and adipose tissue inflammatory markers in obese women. Inflammation 36 (6):1239–47. doi: 10.1007/s10753-013-9661-8.
  • Lam, Y. Y., S. Ghosh, A. E. Civitarese, and E. Ravussin. 2016. Six-month calorie restriction in overweight individuals elicits transcriptomic response in subcutaneous adipose tissue that is distinct from effects of energy deficit. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 71 (10):1258–65. doi: 10.1093/gerona/glv194.
  • Lambert, C. P., N. R. Wright, B. N. Finck, and D. T. Villareal. 2008. Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. Journal of Applied Physiology 105 (2):473–8. doi: 10.1152/japplphysiol.00006.2008.
  • Lemieux, I., A. Pascot, D. Prud’homme, N. Alméras, P. Bogaty, A. Nadeau, J. Bergeron, and J.-P. Després, 2001. Elevated C-reactive protein: Another component of the atherothrombotic profile of abdominal obesity. Arteriosclerosis, Thrombosis, and Vascular Biology 21 (6):961–7. doi: 10.1161/01.ATV.21.6.961.
  • Loria-Kohen, V., C. Fernández-Fernández, L. M. Bermejo, E. Morencos, B. Romero-Moraleda, and C. Gómez-Candela. 2013. Effect of different exercise modalities plus a hypocaloric diet on inflammation markers in overweight patients: A randomised trial. Clinical Nutrition 32 (4):511–8. doi: 10.1016/j.clnu.2012.10.015.
  • Maachi, M., L. Piéroni, E. Bruckert, C. Jardel, S. Fellahi, B. Hainque, J. Capeau, and J.-P. Bastard. 2004. Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women. International Journal of Obesity and Related Metabolic Disorders 28 (8):993–7. doi: 10.1038/sj.ijo.0802718.
  • Miller, W. C., D. Koceja, and E. Hamilton. 1997. A meta-analysis of the past 25 years of weight loss research using diet, exercise or diet plus exercise intervention. International Journal of Obesity 21 (10):941–7. doi: 10.1038/sj.ijo.0800499.
  • Mirza, S., M. Hossain, C. Mathews, P. Martinez, P. Pino, J. L. Gay, A. Rentfro, J. B. McCormick, and S. P. Fisher-Hoch. 2012. Type 2-diabetes is associated with elevated levels of TNF-alpha, IL-6 and adiponectin and low levels of leptin in a population of Mexican Americans: A cross-sectional study. Cytokine 57 (1):136–42. doi: 10.1016/j.cyto.2011.09.029.
  • Moher, D., A. Liberati, J. Tetzlaff, and D. G. Altman. 2009. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Annals of Internal Medicine 151 (4):264–9. doi: 10.7326/0003-4819-151-4-200908180-00135.
  • Nicklas, B. J., W. Ambrosius, S. P. Messier, G. D. Miller, B. W. J. H. Penninx, R. F. Loeser, S. Palla, E. Bleecker, and M. Pahor. 2004. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: A randomized controlled clinical trial. The American Journal of Clinical Nutrition 79 (4):544–51. doi: 10.1093/ajcn/79.4.544.
  • Oh, S., K. Tanaka, T. Tsujimoto, R. So, T. Shida, and J. Shoda. 2014. Regular exercise coupled to diet regimen accelerates reduction of hepatic steatosis and associated pathological conditions in nonalcoholic fatty liver disease. Metabolic Syndrome and Related Disorders 12 (5):290–8. doi: 10.1089/met.2013.0143.
  • Ott, B., T. Skurk, L. Hastreiter, I. Lagkouvardos, S. Fischer, J. Büttner, T. Kellerer, T. Clavel, M. Rychlik, D. Haller, et al. 2017. Effect of caloric restriction on gut permeability, inflammation markers, and fecal microbiota in obese women. Scientific Reports 7 (1):1–10., doi: 10.1038/s41598-017-12109-9.
  • Ouchi, N., S. Kihara, T. Funahashi, T. Nakamura, M. Nishida, M. Kumada, Y. Okamoto, K. Ohashi, H. Nagaretani, K. Kishida, et al. 2003. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation 107 (5):671–4. doi: 10.1161/01.CIR.0000055188.83694.B3.
  • Ounis, O. B., M. Elloumi, G. Lac, E. Makni, E. Van Praagh, H. Zouhal, Z. Tabka, and M. Amri. 2009. Two-month effects of individualized exercise training with or without caloric restriction on plasma adipocytokine levels in obese female adolescents. Annales d'endocrinologie 70 (4):235–41.
  • Park, H. S., J. Y. Park, and R. Yu. 2005. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Research and Clinical Practice 69 (1):29–35. doi: 10.1016/j.diabres.2004.11.007.
  • Pedersen, L. R., R. H. Olsen, C. Anholm, R. L. Walzem, M. Fenger, J. Eugen-Olsen, S. B. Haugaard, and E. Prescott. 2016. Weight loss is superior to exercise in improving the atherogenic lipid profile in a sedentary, overweight population with stable coronary artery disease: A randomized trial. Atherosclerosis 246:221–8. doi: 10.1016/j.atherosclerosis.2016.01.001.
  • Pessin, J. E., and H. Kwon. 2013. Adipokines mediate inflammation and insulin resistance. Frontiers in Endocrinology 4:71. doi: 10.3389/fendo.2013.00071.
  • Pietrocola, F., J. Pol, E. Vacchelli, S. Rao, D. P. Enot, E. E. Baracco, S. Levesque, F. Castoldi, N. Jacquelot, T. Yamazaki, et al. 2016. Caloric restriction mimetics enhance anticancer immunosurveillance. Cancer Cell 30 (1):147–60. doi: 10.1016/j.ccell.2016.05.016.
  • Rejeski, W. J., A. P. Marsh, J. Fanning, W. T. Ambrosius, M. P. Walkup, and B. J. Nicklas. 2019. Dietary weight loss, exercise, and inflammation in older adults with overweight or obesity and cardiometabolic disease. Obesity 27 (11):1805–11. doi: 10.1002/oby.22600.
  • Rokling-Andersen, M. H., J. E. Reseland, M. B. Veierød, S. A. Anderssen, D. R. Jacobs, P. Urdal, J.-O. Jansson, and C. A. Drevon. 2007. Effects of long-term exercise and diet intervention on plasma adipokine concentrations. The American Journal of Clinical Nutrition 86 (5):1293–301. doi: 10.1093/ajcn/86.5.1293.
  • Ross, R. 2000. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men: A randomized, controlled trial. Annals of Internal Medicine 133 (2):92–103. doi: 10.7326/0003-4819-133-2-200007180-00008.
  • Ryan, A. S., S. Ge, J. B. Blumenthal, M. C. Serra, S. J. Prior, and A. P. Goldberg. 2014. Aerobic exercise and weight loss reduce vascular markers of inflammation and improve insulin sensitivity in obese women. Journal of the American Geriatrics Society 62 (4):607–14. doi: 10.1111/jgs.12749.
  • Scott, H. A., P. G. Gibson, M. L. Garg, J. J. Pretto, P. J. Morgan, R. Callister, and L. G. Wood. 2013. Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: A randomized trial. Clinical and Experimental Allergy 43 (1):36–49. doi: 10.1111/cea.12004.
  • Selvin, E., N. P. Paynter, and T. P. Erlinger. 2007. The effect of weight loss on C-reactive protein: A systematic review. Archives of Internal Medicine 167 (1):31–9. doi: 10.1001/archinte.167.1.31.
  • Silverman, N. E., B. J. Nicklas, and A. S. Ryan. 2009. Addition of aerobic exercise to a weight loss program increases BMD, with an associated reduction in inflammation in overweight postmenopausal women. Calcified Tissue International 84 (4):257–65. doi: 10.1007/s00223-009-9232-z.
  • Sirico, F., A. Bianco, G. D'Alicandro, C. Castaldo, S. Montagnani, R. Spera, F. Di Meglio, and D. Nurzynska. 2018. Effects of physical exercise on adiponectin, leptin, and inflammatory markers in childhood obesity: Systematic review and meta-analysis. Childhood Obesity (Print) 14 (4):207–17. doi: 10.1089/chi.2017.0269.
  • Snel, M., J. A. van Diepen, T. Stijnen, H. Pijl, J. A. Romijn, A. E. Meinders, P. Voshol, and I. M. Jazet. 2011. Immediate and long-term effects of addition of exercise to a 16-week very low calorie diet on low-grade inflammation in obese, insulin-dependent type 2 diabetic patients. Food and Chemical Toxicology 49 (12):3104–11. doi: 10.1016/j.fct.2011.09.032.
  • Steckhan, N., C.-D. Hohmann, C. Kessler, G. Dobos, A. Michalsen, and H. Cramer. 2016. Effects of different dietary approaches on inflammatory markers in patients with metabolic syndrome: A systematic review and meta-analysis. Nutrition (Burbank, Los Angeles County, Calif.) 32 (3):338–48. doi: 10.1016/j.nut.2015.09.010.
  • Straznicky, N. E., E. A. Lambert, P. J. Nestel, M. T. McGrane, T. Dawood, M. P. Schlaich, K. Masuo, N. Eikelis, B. de Courten, J. A. Mariani, et al. 2010. Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects. Diabetes 59 (1):71–9. doi: 10.2337/db09-0934.
  • Swardfager, W., N. Herrmann, S. Cornish, G. Mazereeuw, S. Marzolini, L. Sham, and K. L. Lanctôt. 2012. Exercise intervention and inflammatory markers in coronary artery disease: A meta-analysis. American Heart Journal 163 (4):666–76. e3. doi: 10.1016/j.ahj.2011.12.017.
  • Thompson, D., F. Karpe, M. Lafontan, and K. Frayn. 2012. Physical activity and exercise in the regulation of human adipose tissue physiology. Physiological Reviews 92 (1):157–91. doi: 10.1152/physrev.00012.2011.
  • Thompson, G., G. W. Davison, J. Crawford, and C. M. Hughes. 2020. Exercise and inflammation in coronary artery disease: A systematic review and meta-analysis of randomised trials. Journal of Sports Sciences 38 (7):814–26. doi: 10.1080/02640414.2020.1735684.
  • Van Gaal, L., and A. Scheen. 2015. Weight management in type 2 diabetes: Current and emerging approaches to treatment. Diabetes Care 38 (6):1161–72. doi: 10.2337/dc14-1630.
  • Verheggen, R. J. H. M., M. F. H. Maessen, D. J. Green, A. R. M. M. Hermus, M. T. E. Hopman, and D. H. T. Thijssen. 2016. A systematic review and meta‐analysis on the effects of exercise training versus hypocaloric diet: Distinct effects on body weight and visceral adipose tissue. Obesity Reviews 17 (8):664–90. doi: 10.1111/obr.12406.
  • Villareal, D. T., S. Chode, N. Parimi, D. R. Sinacore, T. Hilton, R. Armamento-Villareal, N. Napoli, C. Qualls, and K. Shah. 2011. Weight loss, exercise, or both and physical function in obese older adults. New England Journal of Medicine 364 (13):1218–29. doi: 10.1056/NEJMoa1008234.
  • Wan, X., W. Wang, J. Liu, and T. Tong. 2014. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Medical Research Methodology 14 (1):135. doi: 10.1186/1471-2288-14-135.
  • Weiss, E. P., S. G. Albert, D. N. Reeds, K. S. Kress, J. L. McDaniel, S. Klein, and D. T. Villareal. 2016. Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: A randomized intervention trial. The American Journal of Clinical Nutrition 104 (3):576–86. doi: 10.3945/ajcn.116.131391.
  • Wiklund, P., M. Alen, E. Munukka, S. M. Cheng, B. Yu, S. Pekkala, and S. Cheng. 2014. Metabolic response to 6-week aerobic exercise training and dieting in previously sedentary overweight and obese pre-menopausal women: A randomized trial. Journal of Sport and Health Science 3 (3):217–24. doi: 10.1016/j.jshs.2014.03.013.
  • Yoshimura, E., H. Kumahara, T. Tobina, T. Matsuda, K. Watabe, S. Matono, M. Ayabe, A. Kiyonaga, K. Anzai, Y. Higaki, et al. 2014. Aerobic exercise attenuates the loss of skeletal muscle during energy restriction in adults with visceral adiposity. Obesity Facts 7 (1):26–35. doi: 10.1159/000358576.
  • You, T., D. M. Berman, A. S. Ryan, and B. J. Nicklas. 2004. Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women. The Journal of Clinical Endocrinology and Metabolism 89 (4):1739–46. doi: 10.1210/jc.2003-031310.
  • Yu, N., Y. Ruan, X. Gao, and J. Sun. 2017. Systematic review and meta-analysis of randomized, controlled trials on the effect of exercise on serum leptin and adiponectin in overweight and obese individuals. Hormone and Metabolic Research 49 (3):164–73. doi: 10.1055/s-0042-121605.
  • Yudkin, J. S., M. Kumari, S. E. Humphries, and V. Mohamed-Ali. 2000. Inflammation, obesity, stress and coronary heart disease: Is interleukin-6 the link? Atherosclerosis 148 (2):209–14. doi: 10.1016/S0021-9150(99)00463-3.

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