Phytochemicals in breast milk and their benefits for infants

References

• Andreas, N. J., B. Kampmann, and K. Mehring Le-Doare. 2015. Human breast milk: A review on its composition and bioactivity. Early Human Development 91 (11):629–35. doi: 10.1016/j.earlhumdev.2015.08.013.
   PubMed Web of Science ®Google Scholar
• Ballard, O., and A. L. Morrow. 2013. Human Milk Composition: Nutrients and bioactive factors. Pediatric Clinics of North America 60 (1):49–74. doi: 10.1016/j.pcl.2012.10.002.
   PubMed Web of Science ®Google Scholar
• Bascuñán, K., and M. Araya. 2014. Potenciales intervenciones alimentarias en el manejo y prevención de la alergia en lactantes. Nutrición Hospitalaria 29 (5):69–78. doi: 10.3305/nh.2014.29.5.7239.
   Google Scholar
• Bhooshan, K., and S. Ibrahim. 2009. Plant polyphenols as dietary antioxidants in human health and disease. Oxidative Medicine and Cellular Longevity 2 (5):270–8. doi: 10.4161/oxim.2.5.9498.
   PubMed Web of Science ®Google Scholar
• Bohn, T., C. Desmarchelier, L. O. Dragsted, C. S. Nielsen, W. Stahl, R. Rühl, J. Keijer, and P. Borel. 2017. Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. Molecular Nutrition & Food Research 61 (6):1600685. doi: 10.1002/mnfr.201600685.
   PubMed Web of Science ®Google Scholar
• Brahm, P., and V. Valdés. 2017. [The benefits of breastfeeding and associated risks of replacement with baby formulas]. Revista Chilena de Pediatria 88 (1):7–21. doi: 10.4067/S0370-41062017000100001.
   PubMed Web of Science ®Google Scholar
• Carranco, M. E., M. D. L. C. Carrillo, and F. Pérez. 2011. Carotenoides y su función antioxidante: Revisión. Archivos Latinoamericanos de Nutrición 61 (3):233–41.
   PubMedGoogle Scholar
• Castro-Acosta, M. L., G. N. Lenihan-Geels, C. P. Corpe, and W. L. Hall. 2016. Berries and anthocyanins: Promising functional food ingredients with postprandial glycaemia-lowering effects. The Proceedings of the Nutrition Society 75 (3):342–55. doi: 10.1017/S0029665116000240.
   PubMed Web of Science ®Google Scholar
• Codoñer-Franch, P., M. T. Hernández-Aguilar, A. Navarro-Ruiz, A. B. López-Jaén, C. Borja-Herrero, and V. Valls-Bellés. 2013. Diet supplementation during early lactation with non-alcoholic beer increases the antioxidant properties of breastmilk and decreases the oxidative damage in breastfeeding mothers. Breastfeeding Medicine 8 (2):164–9. doi: 10.1089/bfm.2012.0059.
   PubMed Web of Science ®Google Scholar
• Coronado, M., S. Vega Y León, R. Gutiérrez, M. Vázquez, and C. Radilla. 2015. Antioxidantes: Perspectiva actual para la salud humana. Revista Chilena de Nutrición 42 (2):206–12. doi: 10.4067/S0717-75182015000200014.
   Google Scholar
• Dillard, C. J., and J. B. German. 2000. Phytochemicals: Nutraceuticals and human health. Journal of the Science of Food and Agriculture 80 (12):1744–56. doi: 10.1002/1097-0010(20000915)80:12 < 1744::AID-JSFA725 > 3.0.CO;2-W.
   Web of Science ®Google Scholar
• Duan, B., J. A. Shin, Y. Qin, J. Il Kwon, and K. T. Lee. 2019. A study on the relationship of fat content in human milk on carotenoids content and fatty acid compositions in Korea. Nutrients 11 (9):2072. doi: 10.3390/nu11092072.
   Web of Science ®Google Scholar
• E Silva, A. M. L., G. R. S. da Silva Monteiro, A. N d S. Tavares, and Z. V. R. da Silva Pedrosa. 2019. The early food introduction and the risk of allergies: A review of the literature. Enfermeria Global 18 (2):470–511. doi: 10.6018/eglobal.18.2.345231.
   Google Scholar
• Eidelman, A. I., and R. J. Schanler. 2012. Breastfeeding and the use of human milk. Pediatrics 129 (3):827–41. doi: 10.1542/peds.2011-3552.
   PubMed Web of Science ®Google Scholar
• Ermakov, I. V., M. R. Ermakova, P. S. Bernstein, G. M. Chan, and W. Gellermann. 2013. Resonance Raman based skin carotenoid measurements in newborns and infants. Journal of Biophotonics 6 (10):793–802. doi: 10.1002/jbio.201200195.
   PubMed Web of Science ®Google Scholar
• García-López, R. 2011. Composición e inmunología de la leche humana. Acta Pediátrtica de México 32 (4):223–30.
   Google Scholar
• Haftel, L., Z. Berkovich, and R. Reifen. 2015. Elevated milk β-carotene and lycopene after carrot and tomato paste supplementation. Nutrition (Burbank, Los Angeles County, Calif.) 31 (3):443–5. doi: 10.1016/j.nut.2014.10.009.
   PubMed Web of Science ®Google Scholar
• Hanson, C., E. Lyden, J. Furtado, M. Van Ormer, and A. Anderson-Berry. 2016. A Comparison of nutritional antioxidant content in breast milk, donor milk, and infant formulas. Nutrients 8 (11):681. doi: 10.3390/nu8110681.
   Web of Science ®Google Scholar
• Henning, S., M. Wallenstein, N. Weigel, C. Johnson, J. Yang, R.-P. Lee, M. Korn, et al. 2019. Appearance of ellagic acid metabolites from pomegranate juice in breast milk: A case report. Annals of Clinical Case 4 (1):2–4.
   Google Scholar
• Henriksen, B. S., G. Chan, R. O. Hoffman, M. Sharifzadeh, I. V. Ermakov, W. Gellermann, and P. S. Bernstein. 2013. Interrelationships between maternal carotenoid status and newborn infant macular pigment optical density and carotenoid status. Investigative Ophthalmology & Visual Science 54 (8):5568–78. doi: 10.1167/iovs.13-12331.
   PubMed Web of Science ®Google Scholar
• Horta, B. L., C. Loret De Mola, and C. G. Victora. 2015. Long-term consequences of breastfeeding on cholesterol, obesity, systolic blood pressure and type 2 Diabetes: A systematic review and meta-analysis. Acta Paediatrica (Oslo, Norway : 1992) 104 (467):30–7. doi: 10.1111/apa.13133.
   PubMedGoogle Scholar
• Ip, S., M. Chung, G. Raman, P. Chew, N. Magula, D. DeVine, T. Trikalinos, and J. Lau. 2007. Breastfeeding and maternal and infant health outcomes in developed countries. In Evidence Report/Technology Assessment (153): 1–186. USA, CreateSpace Independent Publishing Platform.
   Google Scholar
• Jochum, F., B. Alteheld, P. Meinardus, N. Dahlinger, A. Nomayo, and P. Stehle. 2017. Mothers' Consumption of Soy Drink But Not Black Tea Increases the Flavonoid Content of Term Breast Milk: A Pilot Randomized, Controlled Intervention Study. Annals of Nutrition & Metabolism 70 (2):147–53. doi: 10.1159/000471857.
   PubMed Web of Science ®Google Scholar
• Kamonpatana, K.,. M. M. Giusti, C. Chitchumroonchokchai, M. Morenocruz, K. M. Riedl, P. Kumar, and M. L. Failla. 2012. Susceptibility of anthocyanins to ex vivo degradation in human saliva. Food Chemistry 135 (2):738–47. doi: 10.1016/j.foodchem.2012.04.110.
   PubMed Web of Science ®Google Scholar
• Kayiran, S. M., D. A. Ince, D. Aldemir, and B. Gurakan. 2013. Investigating the effect of black tea consumption during pregnancy on the oxidant/antioxidant status of breastmilk. Breastfeeding Medicine : The Official Journal of the Academy of Breastfeeding Medicine 8 (2):187–90. doi: 10.1089/bfm.2012.0051.
   PubMed Web of Science ®Google Scholar
• Khymenets, O., M. Rabassa, M. Rodríguez-Palmero, M. Rivero-Urgell, M. Urpi-Sarda, S. Tulipani, P. Brandi, C. Campoy, C. Santos-Buelga, and C. Andres-Lacueva. 2016. Dietary epicatechin is available to breastfed infants through human breast milk in the form of host and microbial metabolites. Journal of Agricultural and Food Chemistry 64 (26):5354–60. doi: 10.1021/acs.jafc.6b01947.
   PubMed Web of Science ®Google Scholar
• Kim, H., H. Yi, J. A. Jung, and N. Chang. 2018. Association between lutein intake and lutein concentrations in human milk samples from lactating mothers in South Korea. European Journal of Nutrition 57 (1):417–21. doi: 10.1007/s00394-017-1414-2.
   PubMed Web of Science ®Google Scholar
• Kramer, M. S., and R. Kakuma. 2002. The optimal duration of exclusive breastfeeding. Tropical Doctor 32 (1):62. 3. doi: 10.1002/14651858.CD003517.pub2.
   PubMed Web of Science ®Google Scholar
• Krinsky, N. I., and E. J. Johnson. 2005. Carotenoid actions and their relation to health and disease. Molecular Aspects of Medicine 26 (6):459–516. doi: 10.1016/j.mam.2005.10.001.
   PubMedGoogle Scholar
• Latorre-Castro, M. L., G. P. Fernández-Deaza, and S. Ucrós-Rodríguez. 2014. Síndrome infantil de muerte súbita: Nuevos conceptos y una misma solución. Revista Facultad de Medicina 62 (2):277–80.
   Google Scholar
• Levêques, A., J. M. Oberson, E. A. Tissot, K. Redeuil, S. K. Thakkar, and E. Campos-Giménez. 2019. Quantification of vitamins A, E, and K and carotenoids in submilliliter volumes of human milk. Journal of AOAC INTERNATIONAL 102 (4):1059–68. doi: 10.5740/jaoacint.19-0016.
   PubMed Web of Science ®Google Scholar
• Lipkie, T. E., A. L. Morrow, Z. E. Jouni, R. J. McMahon, and M. G. Ferruzzi. 2015. Longitudinal survey of carotenoids in human milk from urban cohorts in China, Mexico, and the USA. PLoS ONE 10 (6):e0127729. doi: 10.1371/journal.pone.0127729.
   PubMed Web of Science ®Google Scholar
• Liu, R. H. 2004. Potential synergy of phytochemicals in cancer prevention: Mechanism of action. The Journal of Nutrition 134 (12):3479S–85. doi: 10.1093/jn/134.12.3479S.
   PubMed Web of Science ®Google Scholar
• Machado, M. R., F. Kamp, J. C. Nunes, T. El-Bacha, and A. G. Torres. 2019. Breast milk content of vitamin A and E from early-to mid-Lactation is affected by inadequate dietary intake in brazilian adult women. Nutrients 11 (9):2025. doi: 10.3390/nu11092025.
   PubMed Web of Science ®Google Scholar
• Marín, L., E. M. Miguélez, C. J. Villar, and F. Lombó. 2015. Bioavailability of dietary polyphenols and gut microbiota metabolism: Antimicrobial properties. BioMed Research International 2015 (2015):905215 doi: 10.1155/2015/905215.
   PubMedGoogle Scholar
• Mercado-Mercado, G., L. d l R. Carrillo, A. Wall-Medrano, J. A. L. Díaz, and E. Álvarez-Parrilla. 2013. [Polyphenolic compounds and antioxidant capacity of typically consumed species in Mexico]. Nutr Hosp 28 (1):36–46. doi: 10.3305/nh.2013.28.1.6298.
   PubMed Web of Science ®Google Scholar
• Mezzomo, N., and S. R. S. Ferreira. 2016. Carotenoids functionality, sources, and processing by supercritical technology: A review. Journal of Chemistry 2016:1–16. (): doi: 10.1155/2016/3164312.
   Web of Science ®Google Scholar
• Nagayama, J., K. Noda, T. Uchikawa, I. Maruyama, H. Shimomura, and M. Miyahara. 2014. Effect of maternal Chlorella supplementation on carotenoid concentration in breast milk at early lactation. International Journal of Food Sciences and Nutrition 65 (5):573–6. doi: 10.3109/09637486.2014.898257.
   PubMed Web of Science ®Google Scholar
• Okarter, N., and R. H. Liu. 2010. Health Benefits of Whole Grain Phytochemicals. Critical Reviews in Food Science and Nutrition 50 (3):193–208. doi: 10.1080/10408390802248734.
   PubMed Web of Science ®Google Scholar
• Palomo, I., R. Moore-Carrasco, G. Carrasco, P. Villalobos, and L. Guzmán. 2010. El consumo de tomates previene el desarrollo de enfermedades cardiovasculares y cáncer: Antecedentes epidemiológicos y mecanismos de acción. Idesia (Arica) 28 (3):121–9. doi: 10.4067/S0718-34292010000300016.
   Google Scholar
• Panagos, P. G., R. Vishwanathan, A. Penfield-Cyr, N. R. Matthan, N. Shivappa, M. D. Wirth, J. R. Hebert, and S. Sen. 2016. Breastmilk from obese mothers has pro-inflammatory properties and decreased neuroprotective factors. Journal of Perinatology 36 (4):284–90. doi: 10.1038/jp.2015.199.
   PubMed Web of Science ®Google Scholar
• Poniedziałek, B., P. Rzymski, M. Pięt, M. Gąsecka, A. Stroińska, P. Niedzielski, M. Mleczek, P. Rzymski, and M. Wilczak. 2018. Relation between polyphenols, malondialdehyde, antioxidant capacity, lactate dehydrogenase and toxic elements in human colostrum milk. Chemosphere 191:548–54. doi: 10.1016/j.chemosphere.2017.10.098.
   PubMed Web of Science ®Google Scholar
• Quiñones, M., M. Miguel, and A. Aleixandre. 2012. Los polifenoles, compuestos de origen natural con efectos saludables sobre el sistema cardiovascular. Nutrición Hospitalaria 27 (1):76–89. doi: 10.3305/nh.2012.27.1.5418.
   PubMedGoogle Scholar
• Reboul, E. 2019. Mechanisms of carotenoid intestinal absorption: Where do we stand? Nutrients 11 (4):838. doi: 10.3390/nu11040838.
   PubMed Web of Science ®Google Scholar
• Redeuil, K., A. Lévêques, J.-M. Oberson, S. Bénet, E. Tissot, K. Longet, A. de Castro, C. Romagny, L. Beauport, C. J. Fischer Fumeaux, et al. 2021. Vitamins and carotenoids in human milk delivering preterm and term infants: Implications for preterm nutrient requirements and human milk fortification strategies. Clinical Nutrition (Edinburgh, Scotland) 40 (1):222–8. doi: 10.1016/j.clnu.2020.05.012.
   PubMed Web of Science ®Google Scholar
• Ríos, J. J., A. Xavier, E. Díaz-Salido, I. Arenilla-Vélez, M. Jarén-Galán, J. Garrido-Fernández, J. Aguayo-Maldonado, and A. Pérez-Gálvez. 2017. Xanthophyll esters are found in human colostrum. Molecular Nutrition & Food Research 61 (10):1700296–24. doi: 10.1002/mnfr.201700296.
   Web of Science ®Google Scholar
• Romaszko, E., W. Wiczkowski, J. Romaszko, J. Honke, and M. K. Piskula. 2014. Exposure of breastfed infants to quercetin after consumption of a single meal rich in quercetin by their Mothers. Molecular Nutrition & Food Research 58 (2):221–8. doi: 10.1002/mnfr.201200773.
   PubMed Web of Science ®Google Scholar
• Rubin, L. P., G. M. Chan, B. M. Barrett-Reis, A. B. Fulton, R. M. Hansen, T. L. Ashmeade, J. S. Oliver, A. D. Mackey, R. A. Dimmit, E. E. Hartmann, et al. 2012. Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants. Journal of Perinatology 32 (6):418–24. doi: 10.1038/jp.2011.87.
   PubMed Web of Science ®Google Scholar
• Sankar, M. J., B. Sinha, R. Chowdhury, N. Bhandari, S. Taneja, J. Martines, and R. Bahl. 2015. Optimal breastfeeding practices and infant and child mortality: A systematic review and meta-analysis. Acta Pediatrica. Acta Paediatrica (Oslo, Norway : 1992) 104 (467):3–13. doi: 10.1111/apa.13147.
   PubMed Web of Science ®Google Scholar
• Schellhorn, C., and V. Valdés. 2010. Lactancia Materna: Contenidos Técnicos Para Profesionales de La Salud. Minsal, Unicef y Comisión Nacional de Lactancia.
   Google Scholar
• Sherry, C. L., J. S. Oliver, L. M. Renzi, and B. J. Marriage. 2014. Lutein supplementation increases breast milk and plasma lutein concentrations in lactating women and infant plasma concentrations but does not affect other carotenoids. The Journal of Nutrition 144 (8):1256–63. doi: 10.3945/jn.114.192914.
   PubMed Web of Science ®Google Scholar
• Silberstein, T., B. Hamou, S. Cervil, T. Barak, A. Burg, and O. Saphier. 2019. Colostrum of preeclamptic women has a high level of polyphenols and better resistance to oxidative stress in comparison to that of healthy women. Oxidative Medicine and Cellular Longevity 2019 (2019):1–5. doi: 10.1155/2019/1380605.
   Google Scholar
• Song, B. J., Z. E. Jouni, and M. G. Ferruzzi. 2013. Assessment of phytochemical content in human milk during different stages of lactation. Nutrition (Burbank, Los Angeles County, Calif.) 29 (1):195–202. doi: 10.1016/j.nut.2012.07.015.
   PubMed Web of Science ®Google Scholar
• Strain, H., F. Orchard, and L. Fuentealba. 2017. Acompañando tu lactancia. Manual operativo de lactancia. Chile Crece Contigo, MINSAL.
   Google Scholar
• Tarko, T.,. A. Duda-Chodak, and N. Zajac. 2013. Digestion and absorption of phenolic compounds assessed by in vitro simulation methods. A review. Roczniki Panstwowego Zakladu Higieny 64 (2):79–84.
   PubMedGoogle Scholar
• Tsopmo, A. 2018. Phytochemicals in human milk and their potential antioxidative protection. Antioxidants 7 (2):32. doi: 10.3390/antiox7020032.
   Web of Science ®Google Scholar
• Vásquez-Garibay, E. 2016. Primer Año de Vida. Leche humana y sucedáneos de la leche humana. Gaceta Medica De Mexico 152 (1):13–21.
   PubMedGoogle Scholar
• Velderrain-Rodríguez, G. R., H. Palafox-Carlos, A. Wall-Medrano, J. F. Ayala-Zavala, C. Y. O. Chen, M. Robles-Sánchez, H. Astiazaran-García, E. Alvarez-Parrilla, and G. A. González-Aguilar. 2014. Phenolic compounds: Their journey after intake. Food & Function 5 (2):189–97. doi: 10.1039/c3fo60361j.
   PubMed Web of Science ®Google Scholar
• Victora, C. G., R. Bahl, A. J. D. Barros, G. V. A. França, S. Horton, J. Krasevec, S. Murch, M. J. Sankar, N. Walker, N. C. Rollins, et al. 2016. Breastfeeding in the 21st century: Epidemiology, mechanisms, and lifelong effect. The Lancet 387 (10017):475–90. doi: 10.1016/S0140-6736(15)01024-7.
   PubMed Web of Science ®Google Scholar
• Wallace, T. C., R. L. Bailey, J. B. Blumberg, B. Burton-Freeman, C-yO. Chen, K. M. Crowe-White, A. Drewnowski, S. Hooshmand, E. Johnson, R. Lewis, et al. 2020. Fruits, vegetables, and health: A comprehensive narrative, umbrella review of the science and recommendations for enhanced public policy to improve intake. Critical Reviews in Food Science and Nutrition 60 (13):2174–211. doi: 10.1080/10408398.2019.1632258.
   PubMed Web of Science ®Google Scholar
• Wang, W.,. S. L. Connor, E. J. Johnson, M. L. Klein, S. Hughes, and W. E. Connor. 2007. Effect of Dietary Lutein and Zeaxanthin on Plasma Carotenoids and Their Transport in Lipoproteins in Age-Related Macular Degeneration. The American Journal of Clinical Nutrition 85 (3):762–9. doi: 10.1093/ajcn/85.3.762.
   PubMed Web of Science ®Google Scholar
• Williamson, G. 2017. The role of polyphenols in modern nutrition. Nutrition Bulletin 42 (3):226–35. doi: 10.1111/nbu.12278.
   PubMed Web of Science ®Google Scholar
• Wu, K., J. Zhu, L. Zhou, L. Shen, Y. Mao, Y. Zhao, R. Gao, Z. Lou, M. Cai, and B. Wang. 2020. Lactational changes of fatty acids and fat-soluble antioxidants in human milk from healthy chinese mothers. British Journal of Nutrition 123 (8):841–8. doi: 10.1017/S0007114520000239.
   PubMed Web of Science ®Google Scholar
• Xavier, A., E. Díaz-Salido, I. Arenilla-Vélez, J. Aguayo-Maldonado, J. Garrido-Fernández, J. Fontecha, A. Sánchez-García, and A. Pérez-Gálvez. 2018. Carotenoid content in human colostrum is associated to preterm/full-term birth condition. Nutrients 10 (11):1654. doi: 10.3390/nu10111654.
   Web of Science ®Google Scholar
• Xavier, A., J. Garrido-López, J. Aguayo-Maldonado, J. Garrido-Fernández, J. Fontecha, and A. Pérez-Gálvez. 2019. In vitro digestion of human milk: Influence of the lactation stage on the micellar carotenoids content. Antioxidants 8 (8):291. doi: 10.3390/antiox8080291.
   Web of Science ®Google Scholar
• Xu, X.,. X. Zhao, Y. Berde, Y. L. Low, and M. J. Kuchan. 2019. Milk and plasma lutein and zeaxanthin concentrations in chinese breast-feeding mother–infant dyads with healthy maternal fruit and vegetable intake. Journal of the American College of Nutrition 38 (2):179–84. doi: 10.1080/07315724.2018.1490934.
   PubMed Web of Science ®Google Scholar
• Xue, Y., E. Campos-Giménez, K. M. Redeuil, A. Lévèques, L. Actis-Goretta, G. Vinyes-Pares, Y. Zhang, P. Wang, and S. K. Thakkar. 2017. Concentrations of carotenoids and tocopherols in breast milk from urban chinese mothers and their associations with maternal characteristics: A cross-sectional study. Nutrients 9 (11):1229. doi: 10.3390/nu9111229.
   Web of Science ®Google Scholar
• Zacarías, I., T. Pizarro, L. Rodríguez, D. González, and A. Domper. 2006. Programa «5 al día» para promover el consumo de verduras y frutas en Chile. Revista Chilena de Nutrición 33 (Suppl.1):276–80. doi: 10.4067/S0717-75182006000300010.
   Google Scholar
• Zhang, X., A. Sandhu, I. Edirisinghe, and B. Burton-Freeman. 2018. An exploratory study of red raspberry (Rubus Idaeus L.) (poly)phenols/metabolites in human biological samples. Food & Function 9 (2):806–18. doi: 10.1039/c7fo00893g.
   PubMed Web of Science ®Google Scholar
• Zielinska, M., J. Hamulka, I. Grabowicz-Chądrzyńska, J. Bryś, and A. Wesolowska. 2019. Association between breastmilk LC PUFA, carotenoids and psychomotor development of exclusively breastfed infants. International Journal of Environmental Research and Public Health 16 (7):1144. doi: 10.3390/ijerph16071144.
   Web of Science ®Google Scholar
• Zielinska, M. A., J. Hamulka, and A. Wesolowska. 2019. Carotenoid content in breastmilk in the 3rd and 6th month of lactation and its associations with maternal dietary intake and anthropometric characteristics. Nutrients 11 (1):193. doi: 10.3390/ijerph16071144.
   Web of Science ®Google Scholar
• Zoccali, M., D. Giuffrida, R. Granese, F. Salafia, P. Dugo, and L. Mondello. 2020. Determination of free apocarotenoids and apocarotenoid esters in human colostrum. Analytical and Bioanalytical Chemistry 412 (6):1335–42. doi: 10.1007/s00216-019-02359-z.
   PubMed Web of Science ®Google Scholar