Authenticity of probiotic foods and dietary supplements: A pivotal issue to address

References

• Aguilar-Toalá, J. E., R. Garcia-Varela, H. S. Garcia, V. Mata-Haro, A. F. González-Córdova, B. Vallejo-Cordoba, and A. Hernández-Mendoza. 2018. Postbiotics: An evolving term within the functional foods field. Trends in Food Science & Technology 75:105–14. doi: 10.1016/j.tifs.2018.03.009.
   Web of Science ®Google Scholar
• Allen, S. J., E. G. Martinez, G. V. Gregorio, and L. F. Dans. 2010. Probiotics for treating acute infectious diarrhoea. The Cochrane Database of Systematic Reviews 11:CD003048. doi: 10.1002/14651858.CD003048.pub3.
   PubMed Web of Science ®Google Scholar
• Amagase, H. 2008. Current marketplace for probiotics: A Japanese perspective. Clinical Infectious Diseases 46 (s2):S73–S5. doi: 10.1086/523338.
   PubMedGoogle Scholar
• Ansari, J. M., C. Colasacco, E. Emmanouil, S. Kohlhepp, and O. Harriott. 2019. Strain-level diversity of commercial probiotic isolates of Bacillus, Lactobacillus, and Saccharomyces species illustrated by molecular identification and phenotypic profiling. PLoS ONE 14 (3):e0213841. doi: 10.1371/journal.pone.0213841.
   PubMedGoogle Scholar
• Aureli, P., A. Fiore, C. Scalfaro, M. Casale, and G. Franciosa. 2010. National survey outcomes on commercial probiotic food supplements in Italy. International Journal of Food Microbiology 137 (2-3):265–73. doi: 10.1016/j.ijfoodmicro.2009.12.016.
   PubMed Web of Science ®Google Scholar
• Begum, A. A., D. M. Jakaria, S. M. Anisuzzaman, M. Islam, and S. A. Mahmud. 2015. Market assessment and product evaluation of probiotic containing dietary supplements available in Bangladesh market. Journal of Pharmaceutics 2015:763796. doi: 10.1155/2015/763796.
   PubMedGoogle Scholar
• Behera, S. S., and S. K. Panda. 2020. Ethnic and industrial probiotic foods and beverages: Efficacy and acceptance. Current Opinion in Food Science 32:29–36. doi: 10.1016/j.cofs.2020.01.006.
   Web of Science ®Google Scholar
• Binda, S., C. Hill, E. Johansen, D. Obis, B. Pot, M. E. Sanders, A. Tremblay, and A. C. Ouwehand. 2020. Criteria to Qualify Microorganisms as “Probiotic” in Foods and Dietary Supplements. Frontiers in Microbiology 11:1662. doi: 10.3389/fmicb.2020.01662.
   PubMed Web of Science ®Google Scholar
• Bis-Souza, C. V., F. J. Barba, J. M. Lorenzo, A. L. B. Penna, and A. C. S. Barretto. 2019. New strategies for the development of innovative fermented meat products: A review regarding the incorporation of probiotics and dietary fibers. Food Reviews International 35 (5):467–84. doi: 10.1080/87559129.2019.1584816.
   Web of Science ®Google Scholar
• Blandino, G., D. Fazio, G. P. Petronio, R. Inturri, G. Tempera, and P. M. Furneri. 2016. Labeling quality and molecular characterization studies of products containing Lactobacillus spp. strains. International Journal of Immunopathology and Pharmacology 29 (1):121–8. doi: 10.1177/0394632015600534.
   PubMedGoogle Scholar
• BPOM (Badan Pengawas Obat dan Makanan). 2016. Regulation No. 13/2016 pertaining supervision claims on labeling and advertising of processed food (replacing No. HK 03.1.23.11.11.09909 of 2011).
   Google Scholar
• Briczinski, E. P., J. R. Loquasto, R. Barrangou, E. G. Dudley, A. M. Roberts, and R. F. Roberts. 2009. Strain-specific genotyping of Bifidobacterium animalis subsp. lactis by using single-nucleotide polymorphisms, insertions, and deletions . Applied and Environmental Microbiology 75 (23):7501–8. doi: 10.1128/AEM.01430-09.
   PubMedGoogle Scholar
• Bull, M., S. Plummer, J. Marchesi, and E. Mahenthiralingam. 2013. The life history of Lactobacillus acidophilus as a probiotic: A tale of revisionary taxonomy, misidentification and commercial success. FEMS Microbiology Letters 349 (2):77–87. doi: 10.1111/1574-6968.12293.
   PubMedGoogle Scholar
• Canganella, F., S. Paganini, M. Ovidi, A. M. Vettraino, L. Bevilacqua, S. Massa, and L. D. Trovatelli. 1997. A microbiological investigation on probiotic pharmaceutical products used for human health. Microbiological Research 152 (2):171–9. doi: 10.1016/S0944-5013(97)80009-2.
   PubMedGoogle Scholar
• Cassani, L., A. Gomez-Zavaglia, and J. Simal-Gandara. 2020. Technological strategies ensuring the safe arrival of beneficial microorganisms to the gut: From food processing and storage to their passage through the gastrointestinal tract. Food Research International (Ottawa, Ont.) 129:108852 doi: 10.1016/j.foodres.2019.108852.
   PubMed Web of Science ®Google Scholar
• Celandroni, F., A. Vecchione, A. Cara, D. Mazzantini, A. Lupetti, and E. Ghelardi. 2019. Identification of Bacillus species: Implication on the quality of probiotic formulations. PLoS ONE 14 (5):e0217021 doi: 10.1371/journal.pone.0217021.
   PubMed Web of Science ®Google Scholar
• Chen, T., Q. Wu, H. Zhou, K. Deng, X. Wang, F. Meng, S. Yang, X. Wang, N. P. Shah, and H. Wei. 2017. Assessment of commercial probiotic products in China for labelling accuracy and probiotic characterisation of selected isolates. International Journal of Dairy Technology 70 (1):119–26. doi: 10.1111/1471-0307.12331.
   Web of Science ®Google Scholar
• Chiron, C.,. T. A. Tompkins, and P. Burguière. 2018. Flow cytometry: A versatile technology for specific quantification and viability assessment of microorganisms in multistrain probiotic products. Journal of Applied Microbiology 124 (2):572–84. doi: 10.1111/jam.13666.
   PubMed Web of Science ®Google Scholar
• Council for Responsible Nutrition and International Probiotics Association. 2017. Best Practices Guidelines for Probiotics. Accessed February 12, 2020. https://www.crnusa.org/sites/default/files/pdfs/CRN-IPA-Best-Practices-Guidelines-for-Probiotics.pdf.
   Google Scholar
• Dahllöf, I., H. Baillie, and S. Kjelleberg. 2000. rpoB-based microbial community analysis avoids limitations inherent in 16S rRNA gene intraspecies heterogeneity. Appl Environ Microbiol 66 (8):3376– 80. doi: 10.1128/AEM.66.8.3376-3380.2000.
   PubMed Web of Science ®Google Scholar
• Davis, C. 2014. Enumeration of probiotic strains: Review of culture-dependent and alternative techniques to quantify viable bacteria. Journal of Microbiological Methods 103:9–17. doi: 10.1016/j.mimet.2014.04.012.
   PubMed Web of Science ®Google Scholar
• de Simone, C. 2019. The unregulated probiotic market. Clinical Gastroenterology and Hepatology : The Official Clinical Practice Journal of the American Gastroenterological Association 17 (5):809–17. doi: 10.1016/j.cgh.2018.01.018.
   PubMed Web of Science ®Google Scholar
• Desai, A. R., N. P. Shah, and I. B. Powell. 2006. Discrimination of dairy industry isolates of the Lactobacillus casei group. Journal of Dairy Science 89 (9):3345–51. doi: 10.3168/jds.S0022-0302(06)72371-2.
   PubMed Web of Science ®Google Scholar
• Di Lena, M., G. M. Quero, E. Santovito, J. Verran, M. De Angelis, and V. Fusco. 2015. A selective medium for isolation and accurate enumeration of Lactobacillus casei -group members in probiotic milks and dairy products. International Dairy Journal 47:27–36. doi: 10.1016/j.idairyj.2015.01.018.
   Web of Science ®Google Scholar
• Dietary Supplement Health and Education Act, Pub L. No.103-417 (Oct 25, 1994). Dietary Supplement Health and Education Act, Pub L. No.103-417 (Oct 25, 1994)
   Google Scholar
• Dioso, C. M., P. Vital, K. Arellano, H. Park, S. D. Todorov, Y. Ji, and W. Holzapfel. 2020. Do Your Kids Get What You Paid for? Evaluation of Commercially Available Probiotic Products Intended for Children in the Republic of the Philippines and the Republic of Korea. Foods 9 (9):1229. doi: 10.3390/foods9091229.
   Web of Science ®Google Scholar
• Directive 2000/13/EC of the European Parliament and of the Council of 20 March 2000 on the approximation of the laws of the Member States relating to the labelling, presentation and advertising of foodstuffs; Official Journal of the European Communities; 6 May 2000. L 109/29-42.
   Google Scholar
• Drago, L., V. Rodighiero, T. Celeste, L. Rovetto, and E. De Vecchi. 2010. Microbiological evaluation of commercial probiotic products available in the USA in 2009. Journal of Chemotherapy (Florence, Italy) 22 (6):373–7. doi: 10.1179/joc.2010.22.6.373.
   PubMed Web of Science ®Google Scholar
• Drisko, J., B. Bischoff, C. Giles, M. Adelson, R. S. Rao, and R. Mccallum. 2005. Evaluation of five probiotic products for label claims by DNA extraction and polymerase chain reaction analysis. Digestive Diseases and Sciences 50 (6):1113–7. doi: 10.1007/s10620-005-2714-6.
   PubMed Web of Science ®Google Scholar
• EFSA (European Food Safety Authority). 2010. Scientific Opinion on the substantiation of health claims related to non-characterised bacteria and yeasts pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 8 (2):1470. doi: 10.2903/j.efsa.2010.1470.
   Google Scholar
• EFSA (European Food Safety Authority). 2013. Scientific opinion on the maintenance of the list of QPS biological agents intentionally added to food and feed (2013. update). EFSA Journal 11 (11):3449. doi: 10.2903/j.efsa.2013.3449.
   Google Scholar
• Enujiugha, V. N., and A. A. Badejo. 2017. Probiotic potentials of cereal-based beverages. Critical Reviews in Food Science and Nutrition 57 (4):790–804. doi: 10.1080/10408398.2014.930018.
   PubMed Web of Science ®Google Scholar
• European Commission. 2002. Commission Regulation of the European Parliament and of the Council of 28 January 2002 laying down the general principles and requirements of food law, establishing the European Food Safety Authority and laying down procedures in matters of food safety, 178/2002/EC. Official Journal, L 31, 1.2.2002.
   Google Scholar
• FAO/WHO (Food and Agriculture Organization of the United Nations/World Health Organization). 2002. Guidelines for the evaluation of probiotics in food. https://www.who.int/foodsafety/fs_management/en/probiotic_guidelines.pdf
   Google Scholar
• FAO/WHO (Food and Agriculture Organization of the United Nations/World Health Organization). 2006. Probiotics in Food. Health and nutritional properties and guidelines for evaluation. http://www.fao.org/3/a-a0512e.pdf
   Google Scholar
• FAO/WHO (Food and Agriculture Organization of the United Nations/World Health Organization). 2019. Codex Alimentarius Commission. Discussion Paper on Harmonized Probiotic Guidelines for Use in Foods and Dietary Supplements. Agenda Item 11; CX/NFSDU 19/41/11. Accessed December 16, 2020. http://www.fao.org/fao-who-codexalimentarius/sh-proxy/en/?lnk=1&url=https%253A%252F%252Fworkspace.fao.org%252Fsites%252Fcodex%252FMeetings%252FCX-720-41%252FWD%252Fnf41_11e.pdf.
   Google Scholar
• Fasoli, S., M. Marzotto, L. Rizzotti, F. Rossi, F. Dellaglio, and S. Torriani. 2003. Bacterial composition of commercial probiotic products as evaluated by PCR-DGGE analysis. International Journal of Food Microbiology 82 (1):59–70. doi: 10.1016/S0168-1605(02)00259-3.
   PubMed Web of Science ®Google Scholar
• FDA (US Food and Drug Administration). 2016. Dietary Supplements: New Dietary Ingredient Notifications and Related Issues: Guidance for Industry. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Food Safety and Applied Nutrition. http://www.fda.gov/downloads/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/UCM515733.pdf
   Google Scholar
• FDA (US Food and Drug Administration). 2018. Draft Guidance: Policy Regarding Quantitative Labeling of Dietary Supplements Containing Live Microbials: Guidance for Industry. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Food Safety and Applied Nutrition. Accessed December 20, 2020. https://www.fda.gov/downloads/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/UCM619529.pdf.
   Google Scholar
• Felis, G. E., S. Torriani, A. B. Flórez, and B. Mayo. 2018. Genomic characterisation of starter cultures and probiotic bacteria. In Probiotic Dairy Products, ed. A. Y. Tamine and L. V. Thomas, 37–65. 2nd ed. Oxford: Wiley and Sons.
   Google Scholar
• Fiore, W., S. Arioli, and S. Guglielmetti. 2020. The Neglected Microbial Components of. Microorganisms 8 (8):1177. doi: 10.3390/microorganisms8081177.
   PubMed Web of Science ®Google Scholar
• Flach, J., M. B. van der Waal, M. van den Nieuwboer, E. Claassen, and O. F. A. Larsen. 2018. The underexposed role of food matrices in probiotic products: Reviewing the relationship between carrier matrices and product parameters. Critical Reviews in Food Science and Nutrition 58 (15):2570–84. doi: 10.1080/10408398.2017.1334624.
   PubMed Web of Science ®Google Scholar
• Foglia, C., S. Allesina, A. Amoruso, A. D. Prisco, and M. Pane. 2020. New insights in enumeration methodologies of probiotic cells in finished products. Journal of Microbiological Methods 175:105993 doi: 10.1016/j.mimet.2020.105993.
   PubMed Web of Science ®Google Scholar
• Fredua-Agyeman, M., S. Parab, and S. Gaisford. 2016. Evaluation of commercial probiotic products. British Journal of Pharmacy 1 (1):84–9. doi: 10.5920/bjpharm.2016.11.
   Google Scholar
• Furtado Martins, E. M., A. Mota Ramos, E. S. Lago Vanzela, P. César Stringheta, C. L. de Oliveira Pinto, and J. M. Martins. 2013. Products of vegetable origin: A new alternative for the consumption of probiotic bacteria. Food Research International 51 (2):764–70. doi: 10.1016/j.foodres.2013.01.047.
   Web of Science ®Google Scholar
• Fusco, V., and G. M. Quero. 2014. Culture-dependent and culture-independent nucleic-acid-based methods used in the microbial safety assessment of milk and dairy products. Compr Rev Food Sci Food Saf 13 (4):493–537. doi: 10.1111/1541-4337.12074.
   PubMed Web of Science ®Google Scholar
• Fusco, V., M. Riccardi, and G. M. Quero. 2012. Thin agar layer- versus most probable number-PCR to enumerate viable and stressed Escherichia coli O157:H7 and application in a traditional raw milk pasta filata cheese. International Journal of Food Microbiology 159 (1):1–8. doi: 10.1016/j.ijfoodmicro.2012.07.013.
   PubMed Web of Science ®Google Scholar
• Goldstein, E. J., D. M. Citron, M. C. Claros, and K. L. Tyrrell. 2014. Bacterial counts from five over-the-counter probiotics: Are you getting what you paid for? Anaerobe 25:1–4. doi: 10.1016/j.anaerobe.2013.10.005.
   PubMed Web of Science ®Google Scholar
• Hamilton-Miller, J. M. T., and S. Shah. 2002. Deficiencies in microbiological quality and labeling of probiotic supplements. International Journal of Food Microbiology 72 (1-2):175–6. doi: 10.1016/S0168-1605(01)00703-6.
   PubMed Web of Science ®Google Scholar
• Hamilton-Miller, J. M., S. Shah, and C. T. Smith. 1996. "Probiotic" remedies are not what they seem. BMJ (Clinical Research ed.) 312 (7022):55–6. doi: 10.1136/bmj.312.7022.55c.
   PubMedGoogle Scholar
• Hamilton-Miller, J. M., S. Shah, and J. T. Winkler. 1999. Public health issues arising from microbiological and labelling quality of foods and supplements containing probiotic microorganisms. Public Health Nutrition 2 (2):223–9. doi: 10.1017/S1368980099000282.
   PubMed Web of Science ®Google Scholar
• Hansen, S., P. Tang, A. Kiefer, K. Galles, C. Wong, and W. Morovic. 2019. Droplet Digital PCR Is an Improved Alternative Method for High-Quality Enumeration of Viable Probiotic Strains. Frontiers in Microbiology 10:3025 doi: 10.3389/fmicb.2019.03025.
   PubMed Web of Science ®Google Scholar
• Hill, C., F. Guarner, G. Reid, G. R. Gibson, D. J. Merenstein, B. Pot, L. Morelli, R. B. Canani, H. J. Flint, S. Salminen, et al. 2014. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature Reviews. Gastroenterology & Hepatology 11 (8):506–14. doi: 10.1038/nrgastro.2014.66.
   PubMed Web of Science ®Google Scholar
• Hill, C., K. Scott, T. R. Klaenhammer, E. Quigley, and M. E. Sanders. 2016. Probiotic nomenclature matters. Gut Microbes 7 (1):1–2. doi: 10.1080/19490976.2015.1127484.
   PubMed Web of Science ®Google Scholar
• Hill, D., I. Sugrue, C. Tobin, C. Hill, C. Stanton, and R. P. Ross. 2018. The Lactobacillus casei group: History and health related applications. Frontiers in Microbiology 9:2107. doi: 10.3389/fmicb.2018.02107.
   PubMed Web of Science ®Google Scholar
• Holzapfel, W. H., and B. J. Wood, eds. Lactic Acid Bacteria: Biodiversity and Taxonomy. Chichester, UK: Wiley Blackwell.
   Google Scholar
• Homayouni, A., F. Ansari, A. Azizi, H. Pourjafar, and M. Madadi. 2020. Cheese as a potential food carrier to deliver probiotic microorganisms into the human gut: A review. Current Nutrition & Food Science 16 (1):15–28. doi: 10.2174/1573401314666180817101526.
   Web of Science ®Google Scholar
• Huys, G., N. Botteldoorn, F. Delvigne, L. De Vuyst, M. Heyndrickx, B. Pot, J. ‐J. Dubois, and G. Daube. 2013. Microbial characterization of probiotics-advisory report of the Working Group "8651 Probiotics" of the Belgian Superior Health Council (SHC). Molecular Nutrition & Food Research 57 (8):1479–504. doi: 10.1002/mnfr.201300065.
   PubMed Web of Science ®Google Scholar
• Huys, G., M. Vancanneyt, K. D'Haene, V. Vankerckhoven, H. Goossens, and J. Swings. 2006. Accuracy of species identity of commercial bacterial cultures intended for probiotic or nutritional use. Research in Microbiology 157 (9):803–10. doi: 10.1016/j.resmic.2006.06.006.
   PubMed Web of Science ®Google Scholar
• International Organization for Standardization. 2015. ISO 19344:2015 (IDF 232): Milk and milk products – starter cultures, probiotics and fermented products – quantification of lactic acid bacteria by flow cytometry. http://www.iso.org/iso/catalogue_detail?csnumber=64658.
   Google Scholar
• Jackson, S. A., J. L. Schoeni, C. Vegge, M. Pane, B. Stahl, M. Bradley, V. S. Goldman, P. Burguière, J. B. Atwater, and M. E. Sanders. 2019. Improving end-user trust in the quality of commercial probiotic products. Frontiers in Microbiology 10:739 doi: 10.3389/fmicb.2019.00739.
   PubMed Web of Science ®Google Scholar
• Judicial Commission of the International Committee on Systematics of Bacteria. 2008. The type strain of Lactobacillus casei is ATCC 393, ATCC 334 cannot serve as the type because it represents a different taxon, the name Lactobacillus paracasei and its subspecies names are not rejected and the revival of the name ‘Lactobacillus zeae’ contravenes Rules 51b (1) and (2) of the International Code of Nomenclature of Bacteria. Opinion 82. International Journal of Systematic and Evolutionary Microbiology 58 (7):1764–5. doi: 10.1099/ijs.0.2008/005330-0.
   PubMedGoogle Scholar
• Kareb, O., and M. Aïder. 2019. Whey and its derivatives for probiotics, prebiotics, synbiotics, and functional foods: A critical Review. Probiotics and Antimicrobial Proteins 11 (2):348–69. doi: 10.1007/s12602-018-9427-6.
   PubMed Web of Science ®Google Scholar
• Kelleher, P., J. Murphy, J. Mahony, and D. van Sinderen. 2015. Next-generation sequencing as an approach to dairy starter selection . Dairy Science & Technology 95:545–68. doi: 10.1007/s13594-015-0227-4.
   PubMed Web of Science ®Google Scholar
• Kelly, D., J. I. Campbell, T. P. King, G. Grant, E. A. Jansson, A. G. Coutts, S. Pettersson, and S. Conway. 2004. Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nature Immunology 5 (1):104–12. doi: 10.1038/ni1018.
   PubMed Web of Science ®Google Scholar
• Kesavelu, D., A. Rohit, I. Karunasagar, and I. Karunasagar. 2020. Composition and laboratory correlation of commercial probiotics in india. Cureus 12 (11):e11334 doi: 10.7759/cureus.11334.
   PubMed Web of Science ®Google Scholar
• Kim, E., S. M. Yang, B. Lim, S. H. Park, B. Rackerby, and H. Y. Kim. 2020. Design of PCR assays to specifically detect and identify 37 Lactobacillus species in a single 96 well plate. BMC Microbiol 20 (1):96.doi: 10.1186/s12866-020-01781-z.
   PubMed Web of Science ®Google Scholar
• Klaenhammer, T., E. Altermann, F. Arigoni, A. Bolotin, F. Breidt, J. Broadbent, R. Cano, S. Chaillou, J. Deutscher, M. Gasson, et al. 2002. Discovering lactic acid bacteria by genomics. Antonie Van Leeuwenhoek 82 (1-4):29–58. doi: 10.1023/A:1020638309912.
   PubMed Web of Science ®Google Scholar
• Klein, G. 2011. Antibiotic resistance and molecular characterization of probiotic and clinical Lactobacillus strains in relation to safety aspects of probiotics. Foodborne Pathogens and Disease 8 (2):267–81. doi: 10.1089/fpd.2010.0672.
   PubMed Web of Science ®Google Scholar
• Kolaček, S., I. Hojsak, R. Berni Canani, A. Guarino, F. Indrio, R. Orel, B. Pot, R. Shamir, H. Szajewska, Y. Vandenplas, et al. 2017. Commercial probiotic products: A call for improved quality control. a position paper by the ESPGHAN working group for probiotics and prebiotics. Journal of Pediatric Gastroenterology and Nutrition 65 (1):117–24. doi: 10.1097/MPG.0000000000001603.
   PubMed Web of Science ®Google Scholar
• Kramer, M., N. Obermajer, B. Bogovic Matijasić, I. Rogelj, and V. Kmetec. 2009. Quantification of live and dead probiotic bacteria in lyophilised product by real-time PCR and by flow cytometry. Applied Microbiology and Biotechnology 84 (6):1137–47. doi: 10.1007/s00253-009-2068-7.
   PubMed Web of Science ®Google Scholar
• Lee, J. H., V. N. Karamychev, S. A. Kozyavkin, D. Mills, A. R. Pavlov, N. V. Pavlova, N. N. Polouchine, P. M. Richardson, V. V. Shakhova, A. I. Slesarev, et al. 2008. Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth. BMC Genomics 9:247 doi: 10.1186/1471-2164-9-247.
   PubMed Web of Science ®Google Scholar
• Lewis, Z. T., G. Shani, C. F. Masarweh, M. Popovic, S. A. Frese, D. A. Sela, M. A. Underwood, and D. A. Mills. 2016. Validating bifidobacterial species and subspecies identity in commercial probiotic products. Pediatr Res 79 (3):445–52. doi: 10.1038/pr.2015.244.
   PubMed Web of Science ®Google Scholar
• Loquasto, J. R., R. Barrangou, E. G. Dudley, B. Stahl, C. Chen, and R. F. Roberts. 2013. Bifidobacterium animalis subsp. lactis ATCC 27673 is a genomically unique strain within its conserved subspecies. Applied and Environmental Microbiology 79 (22):6903–10. doi: 10.1128/AEM.01777-13.
   PubMed Web of Science ®Google Scholar
• Lugli, G. A., M. Mangifesta, L. Mancabelli, C. Milani, F. Turroni, A. Viappiani, D. van Sinderen, and M. Ventura. 2019. Compositional assessment of bacterial communities in probiotic supplements by means of metagenomic techniques. International Journal of Food Microbiology 294:1–9. doi: 10.1016/j.ijfoodmicro.2019.01.011.
   PubMed Web of Science ®Google Scholar
• Lugli, G. A., C. Milani, F. Turroni, S. Duranti, C. Ferrario, A. Viappiani, L. Mancabelli, M. Mangifesta, B. Taminiau, V. Delcenserie, et al. M. 2014. Investigation of the evolutionary development of the genus Bifidobacterium by comparative genomics. Applied and Environmental Microbiology 80 (20):6383–94. doi: 10.1128/AEM.02004-14.
   PubMed Web of Science ®Google Scholar
• Majeed, M.,. S. Majeed, K. Nagabhushanam, A. Punnapuzha, S. Philip, and L. Mundkur. 2018. Rapid assessment of viable but non-culturable Bacillus coagulans MTCC 5856 in commercial formulations using Flow cytometry. PLoS One 13 (2):e0192836 doi: 10.1371/journal.pone.0192836.
   PubMed Web of Science ®Google Scholar
• Makarova, K., A. Slesarev, Y. Wolf, A. Sorokin, B. Mirkin, E. Koonin, A. Pavlov, N. Pavlova, V. Karamychev, N. Polouchine, et al. 2006. Comparative genomics of the lactic acid bacteria. Proceedings of the National Academy of Sciences of the United States of America 103 (42):15611–6. doi: 10.1073/pnas.0607117103.
   PubMed Web of Science ®Google Scholar
• Marcobal, A., M. A. Underwood, and D. A. Mills. 2008. Rapid determination of the bacterial composition of commercial probiotic products by terminal restriction fragment length polymorphism analysis. Journal of Pediatric Gastroenterology and Nutrition 46 (5):608–11. doi: 10.1097/MPG.0b013e3181660694.
   PubMed Web of Science ®Google Scholar
• Marinova, V. Y., I. K. Rasheva, Y. K. Kizheva, Y. D. Dermenzhieva, and P. H. Hristova. 2019. Microbiological quality of probiotic dietary supplements. Biotechnology & Biotechnological Equipment 33 (1):834–41. doi: 10.1080/13102818.2019.1621208.
   Web of Science ®Google Scholar
• Masco, L., G. Huys, E. De Brandt, R. Temmerman, and J. Swings. 2005. Culture-dependent and culture-independent qualitative analysis of probiotic products claimed to contain bifidobacteria. International Journal of Food Microbiology 102 (2):221–30. doi: 10.1016/j.ijfoodmicro.2004.11.018.
   PubMed Web of Science ®Google Scholar
• Milani, C., G. A. Lugli, S. Duranti, F. Turroni, F. Bottacini, M. Mangifesta, B. Sanchez, A. Viappiani, L. Mancabelli, B. Taminiau, et al. 2014. Genomic encyclopedia of type strains of the genus Bifidobacterium. Applied and Environmental Microbiology 80 (20):6290–302. doi: 10.1128/AEM.02308-14.
   PubMed Web of Science ®Google Scholar
• Min, M.,. C. R. Bunt, S. L. Mason, and M. A. Hussain. 2019. Non-dairy probiotic food products: An emerging group of functional foods. Critical Reviews in Food Science and Nutrition 59 (16):2626–41. doi: 10.1080/10408398.2018.1462760.
   PubMed Web of Science ®Google Scholar
• Ministry of Health Malaysia 1985. Regulation 26A. Probiotic culture of the Food Safety and Quality Division, Ministry of Health Malaysia.
   Google Scholar
• Mohkam, M.,. N. Nezafat, A. Berenjian, M. A. Mobasher, and Y. Ghasemi. 2016. Identification of Bacillus Probiotics Isolated from Soil Rhizosphere Using 16S rRNA, recA, rpoB Gene Sequencing and RAPD-PCR. Probiotics and Antimicrobial Proteins 8 (1):8–18. doi: 10.1007/s12602-016-9208-z.
   PubMed Web of Science ®Google Scholar
• Mora, D., R. Filardi, S. Arioli, S. Boeren, S. Aalvink, and W. M. de Vos. 2019. Development of omics-based protocols for the microbiological characterization of multi-strain formulations marketed as probiotics: The case of VSL#3. Microbial Biotechnology 12 (6):1371–86. doi: 10.1111/1751-7915.13476.
   PubMed Web of Science ®Google Scholar
• Morovic, W., A. A. Hibberd, B. Zabel, R. Barrangou, and B. Stahl. 2016. Genotyping by PCR and High-Throughput Sequencing of Commercial Probiotic Products Reveals Composition Biases. Frontiers in Microbiology 7:1747. doi: 10.3389/fmicb.2016.01747.
   PubMed Web of Science ®Google Scholar
• Nazir, Y., S. A. Hussain, A. A. Hamid, and Y. Song. 2018. Probiotics and Their Potential Preventive and Therapeutic Role for Cancer, High Serum Cholesterol, and Allergic and HIV Diseases. BioMed Research International 2018:3428437. doi: 10.1155/2018/3428437.
   PubMed Web of Science ®Google Scholar
• Nyholm, L., A. Koziol, S. Marcos, A. B. Botnen, O. Aizpurua, S. Gopalakrishnan, M. T. Limborg, M. T. P. Gilbert, and A. Alberdi. 2020. Holo-Omics: Integrated Host-Microbiota Multi-omics for Basic and Applied Biological Research. iScience 23 (8):101414.doi: 10.1016/j.isci.2020.101414.
   PubMed Web of Science ®Google Scholar
• Papadimitriou, K., R. Anastasiou, E. Mavrogonatou, J. Blom, N. C. Papandreou, S. J. Hamodrakas, S. Ferreira, P. Renault, P. Supply, B. Pot, et al. 2014. Comparative genomics of the dairy isolate Streptococcus macedonicus ACA-DC 198 against related members of the Streptococcus bovis/Streptococcus equinus complex . BMC Genomics 15:272. doi: 10.1186/1471-2164-15-272.
   PubMed Web of Science ®Google Scholar
• Papadimitriou, K., G. Zoumpopoulou, B. Foligné, V. Alexandraki, M. Kazou, B. Pot, and E. Tsakalidou. 2015. Discovering probiotic microorganisms: In vitro, in vivo, genetic and omics approaches. Frontiers in Microbiology 6:58. doi: 10.3389/fmicb.2015.00058.
   PubMed Web of Science ®Google Scholar
• Parks, D. H., M. Chuvochina, D. W. Waite, C. Rinke, A. Skarshewski, P. A. Chaumeil, and P. Hugenholtz. 2018. A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life. Nat Biotechnol 36 (10):996–1004. doi: 10.1038/nbt.4229.
   PubMed Web of Science ®Google Scholar
• Passerini, D., Beltramo, C. M. Coddeville, Y. Quentin, P. Ritzenthaler, M. L. Daveran, ‐Mingot, and P. L. Bourgeois. 2010. Genes but not genomes reveal bacterial domestication of Lactococcus lactis. PLoS ONE 5 (12):e15306. doi: 10.1371/journal.pone.0015306.
   PubMed Web of Science ®Google Scholar
• Patel, A. R. 2017. Probiotic fruit and vegetable juices- recent advances and future perspective. International Food Research Journal 24 (5):1850–7.
   Web of Science ®Google Scholar
• Patro, J. N., P. Ramachandran, T. Barnaba, M. K. Mammel, J. L. Lewis, and C. A. Elkins. 2016. Culture- independent metagenomic surveillance of commercially available probiotics with high- throughput next-generation sequencing. mSphere 1 (2): e00057-16. doi: 10.1128/mSphere.00057-16.
   PubMed Web of Science ®Google Scholar
• Patro, J. N., P. Ramachandran, J. L. Lewis, M. K. Mammel, T. Barnaba, E. A. Pfeiler, and C. A. Elkins. 2015. Development and utility of the FDA 'GutProbe' DNA microarray for identification, genotyping and metagenomic analysis of commercially available probiotics. J Appl Microbiol 118 (6):1478–88. doi: 10.1111/jam.12795.
   PubMed Web of Science ®Google Scholar
• Postollec, F., H. Falentin, S. Pavan, J. Combrisson, and D. Sohier. 2011. Recent advances in quantitative PCR (qPCR) applications in food microbiology. Food Microbiology 28 (5):848–61. doi: 10.1016/j.fm.2011.02.008.
   PubMed Web of Science ®Google Scholar
• Pridmore, R. D., B. Berger, F. Desiere, D. Vilanova, C. Barretto, A. C. Pittet, M. C. Zwahlen, M. Rouvet, E. Altermann, R. Barrangou, et al. 2004. The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533. Proceedings of the National Academy of Sciences of the United States of America 101 (8):2512–7. doi: 10.1073/pnas.0307327101.
   PubMed Web of Science ®Google Scholar
• Quero, G. M., E. Santovito, A. Visconti, and V. Fusco. 2014. Quantitative detection of Listeria monocytogenes in raw milk and soft cheeses: Culture-independent versus liquid - and solid - based culture-dependent real time PCR approaches. Lwt - Food Science and Technology 58 (1):11–20. doi: 10.1016/j.lwt.2014.03.005.
   Web of Science ®Google Scholar
• Regulation (EC) No. 1924/2006. 2006 of the European Parliament and of the Council of 20 December 2006 on nutrition and health claims made on foods. Official Journal of the European Union OJ L12:3–18. Corrigendum 18.1.2007.
   Google Scholar
• Salmerón, I. 2017. Fermented cereal beverages: From probiotic, prebiotic and synbiotic towards Nanoscience designed healthy drinks. Letters in Applied Microbiology 65 (2):114–24. doi: 10.1111/lam.12740.
   PubMed Web of Science ®Google Scholar
• Salminen, S.,. J. Nurmi, and M. Gueimonde. 2005. The genomics of probiotic intestinal microorganisms. Genome Biology 6 (7):225 doi: 10.1186/gb-2005-6-7-225.
   PubMed Web of Science ®Google Scholar
• Salute, M. d. 2018. Linee Guida su Probiotici e Prebiotici. Direzione Generale per l’Igiene e la Sicurezza degli Alimenti e la Nutrizione - Ufficio 4. http://www.salute.gov.it/imgs/C_17_pubblicazioni_1016_allegato.pdf
   Google Scholar
• Salvetti, E., H. M. B. Harris, G. E. Felis, and P. W. O'Toole. 2018. Comparative genomics of the genus Lactobacillus reveals robust phylogroups that provide the basis for reclassification. Applied and Environmental Microbiology 84 (17):00993–18. doi: 10.1128/AEM.00993-18.
   Web of Science ®Google Scholar
• Salvetti, E., and P. W. O'Toole. 2017. When regulation challenges innovation: The case of the genus Lactobacillus. Trends in Food Science & Technology 66:187–94. doi: 10.1016/j.tifs.2017.05.009.
   Web of Science ®Google Scholar
• SAMR. 2019. SAMR issued Application and Review of Probiotic Health Food. Accessed December 21, 2020. http://www.cirs-reach.com/news-and-articles/SAMR-Issues-Provisions-for-Declaration-and-Review-of-Probiotic-Health-Food-Draft-for-Public-Comments.html.
   Google Scholar
• Sánchez, B., L. Ruiz, M. Gueimonde, and A. Margolles. 2013. Omics for the study of probiotic microorganisms. Food Research International 54 (1):1061–71. doi: 10.1016/j.foodres.2013.01.029.
   Web of Science ®Google Scholar
• Sanders, M. E., L. M. Akkermans, D. Haller, C. Hammerman, J. Heimbach, G. Hörmannsperger, G. Huys, D. D. Levy, F. Lutgendorff, D. Mack, et al. 2010. Safety assessment of probiotics for human use. Gut Microbes 1 (3):164–85. doi: 10.4161/gmic.1.3.12127.
   PubMed Web of Science ®Google Scholar
• Sanders, M. E., A. Benson, S. Lebeer, D. J. Merenstein, and T. R. Klaenhammer. 2018. Shared mechanisms among probiotic taxa: Implications for general probiotic claims. Current Opinion in Biotechnology 49:207–16. doi: 10.1016/j.copbio.2017.09.007.
   PubMed Web of Science ®Google Scholar
• Saxelin, M. 2008. Probiotic formulations and applications, the current probiotics market, and changes in the marketplace: A European perspective. Clinical Infectious Diseases 46 (s2):S76–S79. doi: 10.1086/523337.
   PubMedGoogle Scholar
• Scariot, M. C., G. L. Venturelli, E. S. Prudêncio, and A. C. M. Arisi. 2018. Quantification of Lactobacillus paracasei viable cells in probiotic yoghurt by propidium monoazide combined with quantitative PCR. International Journal of Food Microbiology 264:1–7. doi: 10.1016/j.ijfoodmicro.2017.10.021.
   PubMed Web of Science ®Google Scholar
• Seol, D., S. Y. Jhang, H. Kim, S.-Y. Kim, H.-S. Kwak, S. H. Kim, W. Lee, S. Park, H. Kim, S. Cho, et al. 2019. Accurate and Strict Identification of Probiotic Species Based on Coverage of Whole-Metagenome Shotgun Sequencing Data. Frontiers in Microbiology 10:1683 doi: 10.3389/fmicb.2019.01683.
   PubMed Web of Science ®Google Scholar
• Shao, Y., Z. Wang, Q. Bao, and H. Zhang. 2016. Application of propidium monoazide quantitative real-time PCR to quantify the viability of Lactobacillus delbrueckii ssp. bulgaricus. J Dairy Sci 99 (12):9570–80. doi: 10.3168/jds.2016-11597.
   PubMed Web of Science ®Google Scholar
• Shehata, H. R., and S. G. Newmaster. 2020. Combined targeted and non-targeted PCR based methods reveal high levels of compliance in probiotic products sold as dietary supplements in United States and Canada. Frontiers in Microbiology 11:1095 doi: 10.3389/fmicb.2020.01095.
   PubMed Web of Science ®Google Scholar
• Shehata, H. R., S. Ragupathy, D. Shanmughanandhan, P. Kesanakurti, T. M. Ehlinger, and S. G. Newmaster. 2019. Guidelines for validation of qualitative real-time PCR methods for molecular diagnostic identification of probiotics. Journal of AOAC International 102 (6):1774–8. doi: 10.1093/jaoac/102.6.1774.
   PubMed Web of Science ®Google Scholar
• Shiby, V. K., and H. N. Mishra. 2013. Fermented milks and milk products as functional foods-a review. Critical Reviews in Food Science and Nutrition 53 (5):482–96. doi: 10.1080/10408398.2010.547398.
   PubMed Web of Science ®Google Scholar
• Shori, A. B. 2016. Influence of food matrix on the viability of probiotic bacteria: A review based on dairy and non-dairy beverages. Food Bioscience 13:1–8. doi: 10.1016/j.fbio.2015.11.001.
   Web of Science ®Google Scholar
• Siezen, R. J., and G. Wilson. 2010. Probiotics genomics. Microbial Biotechnology 3 (1):1–9. doi: 10.1111/j.1751-7915.2009.00159.x.
   PubMed Web of Science ®Google Scholar
• Sun, Z., H. M. B. Harris, A. McCann, C. Guo, S. Argimón, W. Zhang, X. Yang, I. B. Jeffery, J. C. Cooney, T. F. Kagawa, et al. 2015. Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera. Nature Communications 6:8322 doi: 10.1038/ncomms9322.
   PubMed Web of Science ®Google Scholar
• Szajewska, H., A. Fordymacka, J. Bardowski, R. K. Górecki, J. Z. Mrukowicz, and A. Banaszkiewicz. 2004. Microbiological and genetic analysis of probiotic products licensed for medicinal purposes. Medical Science Monitor 10 (9):346–50.
   Web of Science ®Google Scholar
• Taverniti, V., and S. Guglielmetti. 2011. The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: Proposal of paraprobiotic concept)). Genes & Nutrition 6 (3):261–74. doi: 10.1007/s12263-011-0218-x.
   PubMed Web of Science ®Google Scholar
• Temmerman, R., B. Pot, G. Huys, and J. Swings. 2003. Identification and antibiotic susceptibility of bacterial isolates from probiotic products. International Journal of Food Microbiology 81 (1):1–10. doi: 10.1016/S0168-1605(02)00162-9.
   PubMed Web of Science ®Google Scholar
• Temmerman, R., I. Scheirlinck, G. Huys, and J. Swings. 2003. Culture-independent analysis of probiotic products by denaturing gradient gel electrophoresis. Applied and Environmental Microbiology 69 (1):220–6. doi: 10.1128/aem.69.1.220-226.2003.
   PubMed Web of Science ®Google Scholar
• Terpou, A., A. Papadaki, I. K. Lappa, V. Kachrimanidou, L. A. Bosnea, and N. Kopsahelis. 2019. Probiotics in food systems: Significance and emerging strategies towards improved viability and delivery of enhanced beneficial value. Nutrients 11 (7):1591. doi: 10.3390/nu11071591.
   PubMed Web of Science ®Google Scholar
• The Spanish Agency for Food Safety and Nutrition (AESAN). 2020. https://www.aesan.gob.es/AECOSAN/web/seguridad_alimentaria/subdetalle/probioticos.htm?idU=1&utm_source=newsletter_1712&utm_medium=email&utm_campaign=importante-probioticos-etiquetado
   Google Scholar
• Turkmen, N., C. Akal, and B. Özer. 2019. Probiotic dairy-based beverages: A review. Journal of Functional Foods 53:62–75. doi: 10.1016/j.jff.2018.12.004.
   Web of Science ®Google Scholar
• Ullah, M., A. Raza, L. Ye, and Z. Yu. 2019. Viability and Composition Validation of Commercial Probiotic Products by Selective Culturing Combined with Next-Generation Sequencing. Microorganisms 7 (7):188. doi: 10.3390/microorganisms7070188.
   Web of Science ®Google Scholar
• Vallabhaneni, S., T. A. Walker, S. R. Lockhart, D. Ng, T. Chiller, R. Melchreit, M. E. Brandt, and R. M. Smith. 2014. Centers for Disease Control and Prevention (CDC). 2015. Notes from the field: Fatal gastrointestinal mucormycosis in a premature infant associated with a contaminated dietary supplement–Connecticut. MMWR. Morbidity and Mortality Weekly Report 64 (6):155–6.
   Web of Science ®Google Scholar
• van Hylckama Vlieg, J. E., J. L. Rademaker, H. Bachmann, D. Molenaar, W. J. Kelly, and R. J. Siezen. 2006. Natural diversity and adaptive responses of Lactococcus lactis. Current Opinion in Biotechnology 17 (2):183–90. doi: 10.1016/j.copbio.2006.02.007.
   PubMed Web of Science ®Google Scholar
• van Reenen, C. A., and L. M. T. Dicks. 2011. Horizontal gene transfer amongst probiotic lactic acid bacteria and other intestinal microbiota: What are the possibilities? A review. Archives of Microbiology 193 (3):157–68. doi: 10.1007/s00203-010-0668-3.
   PubMed Web of Science ®Google Scholar
• Vanhee, L. M. E., F. Goemé, H. J. Nelis, and T. Coenye. 2010. Quality control of fifteen probiotic products containing Saccharomyces boulardii. Journal of Applied Microbiology 109 (5):no–52. doi: 10.1111/j.1365-2672.2010.04805.x.
   Web of Science ®Google Scholar
• Vecchione, A., F. Celandroni, D. Mazzantini, S. Senesi, A. Lupetti, and E. Ghelardi. 2018. Compositional quality and potential gastrointestinal behavior of probiotic products commercialized in Italy. Frontiers in Medicine 5:59. doi: 10.3389/fmed.2018.00059.
   Web of Science ®Google Scholar
• Ventura, M., C. Canchaya, A. Tauch, G. Chandra, G. F. Fitzgerald, K. F. Chater, and D. van Sinderen. 2007. Genomics of Actinobacteria: Tracing the evolutionary history of an ancient phylum. Microbiology and Molecular Biology Reviews : MMBR 71 (3):495–548. doi: 10.1128/MMBR.00005-07.
   PubMed Web of Science ®Google Scholar
• Ventura, M., S. O'Flaherty, M. J. Claesson, F. Turroni, T. R. Klaenhammer, D. van Sinderen, and P. W. O'Toole. 2009. Genome-scale analyses of health-promoting bacteria: Probiogenomics. Nature Reviews. Microbiology 7 (1):61–71. doi: 10.1038/nrmicro2047.
   PubMed Web of Science ®Google Scholar
• Ventura, M., F. Turroni, and D. van Sinderen. 2012. Probiogenomics as a tool to obtain genetic insights into adaptation of probiotic bacteria to the human gut. Bioengineered Bugs 3 (2):73–9. doi: 10.4161/bbug.18540.
   PubMedGoogle Scholar
• Vermeulen, M. J., A. Luijendijk, L. van Toledo, A. H. van Kaam, and I. K. M. Reiss. 2020. Quality of probiotic products for preterm infants: Contamination and missing strains. Acta Paediatrica (Oslo, Norway : 1992) 109 (2):276–9. doi: 10.1111/apa.14976.
   PubMed Web of Science ®Google Scholar
• Vijaya Kumar, B., S. V. N. Vijayendra, and O. V. S. Reddy. 2015. Trends in dairy and non-dairy probiotic products - a review. Journal of Food Science and Technology 52 (10):6112–24. doi: 10.1007/s13197-015-1795-2.
   PubMed Web of Science ®Google Scholar
• Villarreal, M. L., M. Padilha, A. D. Vieira, B. D. Franco, R. C. Martinez, and S. M. Saad. 2013. Advantageous direct quantification of viable closely related probiotics in petit-suisse cheeses under in vitro gastrointestinal conditions by Propidium Monoazide-qPCR. PLoS One. 8 (12):e82102. doi: 10.1371/journal.pone.0082102.
   PubMed Web of Science ®Google Scholar
• Vinderola, G., J. Reinheimer, and S. Salminen. 2019. The enumeration of probiotic issues: From unavailable standardized culture media to a recommended procedure? International Dairy Journal 96:58–65. doi: 10.1016/j.idairyj.2019.04.010.
   Web of Science ®Google Scholar
• Wagner, J., P. Coupland, H. P. Browne, T. D. Lawley, S. C. Francis, and J. Parkhill. 2016. Evaluation of PacBio sequencing for full-length bacterial 16S rRNA gene classification. BMC Microbiology 16 (1):274 doi: 10.1186/s12866-016-0891-4.
   PubMedGoogle Scholar
• Weese, J. S., and H. Martin. 2011. Assessment of commercial probiotic bacterial contents and label accuracy. The Canadian Veterinary Journal = La Revue Veterinaire Canadienne 52 (1):43–6.
   PubMed Web of Science ®Google Scholar
• Yeung, P. S. M., M. E. Sanders, C. L. Kitts, R. Cano, and P. S. Tong. 2002. Species-specific identification of commercial probiotic strains. Journal of Dairy Science 85 (5):1039–51. doi: 10.3168/jds.S0022-0302(02)74164-7.
   PubMed Web of Science ®Google Scholar
• Zawistowska-Rojek, A., T. Zareba, A. Mrówka, and S. Tyski. 2016. Assessment of the microbiological status of probiotic products. Pol J Microbiol 65 (1):97–104. doi: 10.5604/17331331.1197281.
   PubMed Web of Science ®Google Scholar
• Zheng, J., S. Wittouck, E. Salvetti, C. M. A. P. Franz, H. M. B. Harris, P. Mattarelli, P. W. O'Toole, B. Pot, P. Vandamme, J. Walter, et al. 2020. A taxonomic note on the genus Lactobacillus: Description of 23 novel genera, emended description of the genus Lactobacillus Beijerinck 1901, and union of Lactobacillaceae and Leuconostocaceae. International Journal of Systematic and Evolutionary Microbiology 70 (4):2782–858. doi: 10.1099/ijsem.0.004107.
   PubMed Web of Science ®Google Scholar
• Zhu, Q., U. Mai, W. Pfeiffer, S. Janssen, F. Asnicar, J. G. Sanders, P. Belda-Ferre, G. A. Al-Ghalith, E. Kopylova, D. McDonald, et al. 2019. Phylogenomics of 10,575 genomes reveals evolutionary proximity between domains Bacteria and Archaea. Nature Communications 10 (1):5477. doi: 10.1038/s41467-019-13443-4.
   PubMedGoogle Scholar
• Zielińska, D., A. Ołdak, A. Rzepkowska, and K. Zieliński. 2018. Enumeration and identification of probiotic bacteria in food matrices. In Advances in Biotechnology for Food Industry, ed. A. M. Holban and A. M. Grumezescu, 167–96. London: Academic Press. doi: 10.1016/B978-0-12-811443-8.00006-2.
   Google Scholar
• Zimmer, C., and C. Dorea. 2019. Enumeration of Escherichia coli in probiotic products. Microorganisms 7 (10):437. doi: 10.3390/microorganisms7100437.
   Web of Science ®Google Scholar