Association of omega-6 polyunsaturated fatty acids with blood pressure: A systematic review and meta-analysis of observational studies

References

• Aristizabal, J. C., J. Barona, L. I. Gonzalez-Zapata, G. C. Deossa, and A. Estrada. 2016. Fatty acid content of plasma triglycerides may contribute to the heterogeneity in the relationship between abdominal obesity and the metabolic syndrome. Metabolic Syndrome and Related Disorders 14 (6):311–7. doi: 10.1089/met.2015.0168.
   PubMed Web of Science ®Google Scholar
• Bemelmans, W. J., F. A. Muskiet, E. J. Feskens, J. H. de Vries, J. Broer, J. F. May, and B. M. Jong. 2000. Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease. European Journal of Clinical Nutrition 54 (12):865–71. doi: 10.1038/sj.ejcn.1601102.
   PubMed Web of Science ®Google Scholar
• Borges, M. C., A. F. Schmidt, B. Jefferis, S. G. Wannamethee, D. A. Lawlor, M. Kivimaki, M. Kumari, T. R. Gaunt, Y. Ben-Shlomo, T. Tillin, et al. 2020. Circulating fatty acids and risk of coronary heart disease and stroke: Individual participant data meta-analysis in up to 16 126 Participants. Journal of the American Heart Association 9 (5):e013131 doi: 10.1161/JAHA.119.013131.
   PubMed Web of Science ®Google Scholar
• Brown, T. J., J. Brainard, F. Song, X. Wang, A. Abdelhamid, and L. Hooper. 2019. Omega-3, omega-6, and total dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus: Systematic review and meta-analysis of randomised controlled trials. BMJ (Clinical Research ed.) 366:l4697. doi: 10.1136/bmj.l4697.
   PubMedGoogle Scholar
• Carey, R. M., P. K. Whelton, and 2017 ACC/AHA Hypertension Guideline Writing Committee. 2018. Prevention, detection, evaluation, and management of high blood pressure in adults: Synopsis of the 2017 American College of Cardiology/American Heart Association Hypertension guideline. Ann Intern Med 168 (5):351–8. doi: 10.7326/M17-3203.
   PubMed Web of Science ®Google Scholar
• Chandra, A., H. Røsjø, M. Svensson, T. Vigen, H. Ihle-Hansen, E. B. Orstad, O. M. Rønning, M. N. Lyngbakken, S. Nygård, T. Berge, et al. 2020. Plasma linoleic acid levels and cardiovascular risk factors: Results from the Norwegian ACE 1950 Study. European Journal of Clinical Nutrition 74 (12):1707–1717. doi: 10.1038/s41430-020-0641-4.
   PubMed Web of Science ®Google Scholar
• Chen, J., B. Sun, and D. Zhang. 2019. Association of dietary n3 and n6 fatty acids intake with hypertension: NHANES 2007–2014. Nutrients 11 (6):1232. doi: 10.3390/nu11061232.
   Web of Science ®Google Scholar
• Cumpston, M., T. Li, M. J. Page, J. Chandler, V. A. Welch, J. P. Higgins, and J. Thomas. 2019. Updated guidance for trusted systematic reviews: A new edition of the cochrane handbook for systematic reviews of interventions. The Cochrane Database of Systematic Reviews 10:ED000142. doi: 10.1002/14651858.ED000142.
   PubMed Web of Science ®Google Scholar
• Das, U. N. 1995. Essential fatty acid metabolism in patients with essential hypertension, diabetes mellitus and coronary heart disease. Prostaglandins, Leukotrienes and Essential Fatty Acids 52 (6):387–91. doi: 10.1016/0952-3278(95)90066-7.
   PubMed Web of Science ®Google Scholar
• Ding, D., Y. H. Li, M. L. Xiao, H. L. Dong, J. S. Lin, G. D. Chen, Z. Y. Chen, X. Y. Tang, and Y. M. Chen. 2020. Erythrocyte membrane polyunsaturated fatty acids are associated with incidence of metabolic syndrome in middle-aged and elderly people - An 8.8-year prospective study. The Journal of Nutrition 150 (6):1488–98. doi: 10.1093/jn/nxaa039.
   PubMed Web of Science ®Google Scholar
• DerSimonian, R., and N. Laird. 1986. Meta-analysis in clinical trials. Controlled Clinical Trials 7 (3):177–88. doi: 10.1016/0197-2456(86)90046-2.
   PubMedGoogle Scholar
• Ebbesson, S. O., V. S. Voruganti, P. B. Higgins, R. R. Fabsitz, L. O. Ebbesson, S. Laston, W. S. Harris, J. Kennish, B. D. Umans, H. Wang, and, et al. 2015. Fatty acids linked to cardiovascular mortality are associated with risk factors. International Journal of Circumpolar Health 74: 28055. doi: 10.3402/ijch.v74.28055.
   PubMed Web of Science ®Google Scholar
• Egger, M., G. D. Smith, and D. G. Altman. 2001. Systematic reviews in health care: Meta-analysis in context, 2nd ed. 487. London: BMJ Books.
   Google Scholar
• Egger, M., G. D. Smith, M. Schneider, and C. Minder. 1997. Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical Research ed.) 315 (7109):629–34. doi: 10.1136/bmj.315.7109.629.
   PubMed Web of Science ®Google Scholar
• Farvid, M. S., M. Ding, A. Pan, Q. Sun, S. E. Chiuve, L. M. Steffen, W. C. Willett, and F. B. Hu. 2014. Dietary linoleic acid and risk of coronary heart disease: A systematic review and meta-analysis of prospective cohort studies. Circulation 130 (18):1568–78. doi: 10.1161/CIRCULATIONAHA.114.010236.
   PubMed Web of Science ®Google Scholar
• Fazelian, S., E. Sadeghi, S. Firouzi, and F. Haghighatdoost. 2021. Adherence to the vegetarian diet may increase the risk of depression: A systematic review and meta-analysis of observational studies. Nutrition Review. doi: 10.1093/nutrit/nuab013.
   Web of Science ®Google Scholar
• Ferrier, K. E., M. H. Muhlmann, J. P. Baguet, J. D. Cameron, G. L. Jennings, A. M. Dart, and B. A. Kingwell. 2002. Intensive cholesterol reduction lowers blood pressure and large artery stiffness in isolated systolic hypertension. Journal of the American College of Cardiology 39 (6):1020–5. doi: 10.1016/S0735-1097(02)01717-5.
   PubMed Web of Science ®Google Scholar
• Fujii, C., T. Kawai, K. Azuma, Y. Oguma, F. Katsukawa, H. Hirose, K. Tanaka, S. Meguro, H. Matsumoto, and H. Itoh. 2017. Relationships between composition of major fatty acids and fat distribution and insulin resistance in Japanese. Journal of Diabetes Research 2017:1–9. doi: 10.1155/2017/1567467.
   Web of Science ®Google Scholar
• Grimsgaard, S., K. H. Bonaa, B. K. Jacobsen, and K. S. Bjerve. 1999. Plasma saturated and linoleic fatty acids are independently associated with blood pressure. Hypertension (Dallas, Tex. : 1979) 34 (3):478–83. doi: 10.1161/01.HYP.34.3.478.
   PubMed Web of Science ®Google Scholar
• Jang, H., and K. Park. 2020. Omega-3 and omega-6 polyunsaturated fatty acids and metabolic syndrome: A systematic review and meta-analysis. Clinical Nutrition (Edinburgh, Scotland) 39 (3):765–73. doi: 10.1016/j.clnu.2019.03.032.
   PubMed Web of Science ®Google Scholar
• Kaikkonen, J. E., A. Jula, V. Mikkilä, J. S. Viikari, T. Moilanen, T. Nikkari, M. Kähönen, T. Lehtimäki, and O. T. Raitakari. 2012. Childhood serum cholesterol ester fatty acids are associated with blood pressure 27 y later in the cardiovascular risk in young Finns study. The American Journal of Clinical Nutrition 95 (6):1422–31. doi: 10.3945/ajcn.111.030387.
   PubMed Web of Science ®Google Scholar
• Kalinski, P. 2012. Regulation of immune responses by prostaglandin E2. Journal of Immunology (Baltimore, Md: 1950) 188 (1):21–8. doi: 10.4049/jimmunol.1101029.
   PubMed Web of Science ®Google Scholar
• Leng, L., G. C. F. B. Smith, F. G. Fowkes, D. F. Horrobin, K. Ells, N. Morse-Fisher, and G. D. Lowe. 1994. Relationship between plasma essential fatty acids and smoking, serum lipids, blood pressure and haemostatic and rheological factors. Prostaglandins, Leukotrienes and Essential Fatty Acids 51 (2):101–8. doi: 10.1016/0952-3278(94)90085-X.
   PubMed Web of Science ®Google Scholar
• Li, J., M. Guasch-Ferré, Y. Li, and F. B. Hu. 2020. Dietary intake and biomarkers of linoleic acid and mortality: Systematic review and meta-analysis of prospective cohort studies. The American Journal of Clinical Nutrition 112 (1):150–67. doi: 10.1093/ajcn/nqz349.
   PubMed Web of Science ®Google Scholar
• Mills, K. T., J. D. Bundy, T. N. Kelly, J. E. Reed, P. M. Kearney, K. Reynolds, J. Chen, and J. He. 2016. Global disparities of hypertension prevalence and control: A systematic analysis of population-based studies from 90 countries. Circulation 134 (6):441–50. doi: 10.1161/CIRCULATIONAHA.115.018912.
   PubMed Web of Science ®Google Scholar
• Mirmiran, P., H. S. Osseinpour-Niazi, Z. Naderi, Z. Bahadoran, M. Sadeghi, and F. Azizi. 2012. Association between interaction and ratio of ω-3 and ω-6 polyunsaturated fatty acid and the metabolic syndrome in adults. Nutrition (Burbank, Los Angeles County, Calif.) 28 (9):856–63. doi: 10.1016/j.nut.2011.11.031.
   PubMed Web of Science ®Google Scholar
• Miura, K., J. Stamler, H. Nakagawa, P. Elliott, H. Ueshima, Q. Chan, I. J. Brown, I. Tzoulaki, S. Saitoh, A. R. Dyer, and, et al. 2008. Relationship of dietary linoleic acid to blood pressure. The international study of macro-micronutrients and blood pressure study [corrected]. Hypertension 52 (2):408–14. doi: 10.1161/HYPERTENSIONAHA.108.112383.
   PubMed Web of Science ®Google Scholar
• Moher, D., A. Liberati, J. Tetzlaff, D. G. Altman, and PRISMA Group. 2009. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine 6 (7):e1000097. doi: 10.1371/journal.pmed.1000097.
   PubMed Web of Science ®Google Scholar
• Nakamura, H., A. Hara, H. Tsujiguchi, T. Thi Thu Nguyen, Y. Kambayashi, S. Miyagi, Y. Yamada, K. Suzuki, Y. Shimizu, and H. Nakamura. 2018. Relationship between dietary n-6 fatty acid intake and hypertension: Effect of glycated hemoglobin levels. Nutrients 10 (12):1825. doi: 10.3390/nu10121825.
   PubMed Web of Science ®Google Scholar
• Nigam, A., N. Frasure-Smith, F. Lespérance, and P. Julien. 2009. Relationship between n-3 and n-6 plasma fatty acid levels and insulin resistance in coronary patients with and without metabolic syndrome. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD 19 (4):264–70. doi: 10.1016/j.numecd.2008.07.008.
   PubMed Web of Science ®Google Scholar
• Olkin, I., and J. D. Finn. 1995. Correlations redux. Psychological Bulletin 118 (1):155–64. doi: 10.1037/0033-2909.118.1.155.
   Web of Science ®Google Scholar
• Oster, P., L. Arab, B. Schellenberg, C. C. Heuck, R. Mordasini, and G. Schlierf. 1979. Blood pressure and adipose tissue linoleic acid. Research in Experimental Medicine. Zeitschrift Fur Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie 175 (3):287–91. doi: 10.1007/BF01851285.
   PubMedGoogle Scholar
• Ottawa Hospital Research Institute. n. d. Accessed 1 June 2021. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
   Google Scholar
• Park, S., J. Ahn, N. S. Kim, and B. K. Lee. 2017. High carbohydrate diets are positively associated with the risk of metabolic syndrome irrespective to fatty acid composition in women: The KNHANES 2007-2014. International Journal of Food Sciences and Nutrition 68 (4):479–87. doi: 10.1080/09637486.2016.1252318.
   PubMed Web of Science ®Google Scholar
• Petrone, A. B., N. Weir, N. Q. Hanson, R. Glynn, M. Y. Tsai, J. M. Gaziano, and L. Djoussé. 2013. Omega-6 fatty acids and risk of heart failure in the Physicians’ Health Study. The American Journal of Clinical Nutrition 97 (1):66–71. doi: 10.3945/ajcn.112.048991.
   PubMed Web of Science ®Google Scholar
• Ramsden, C. E., D. Zamora, B. Leelarthaepin, S. F. Majchrzak-Hong, K. R. Faurot, C. M. Suchindran, A. Ringel, J. M. Davis, and J. R. Hibbeln. 2013. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: Evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ (Clinical Research ed.) 346:e8707. doi: 10.1136/bmj.e8707.
   PubMed Web of Science ®Google Scholar
• Ricciotti, E., and G. A. Fitzgerald. 2011. Prostaglandins and inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology 31 (5):986–1000. doi: 10.1161/ATVBAHA.110.207449.
   PubMed Web of Science ®Google Scholar
• Riemersma, R. A., D. A. Wood, S. Butler, R. A. Elton, M. Oliver, M. Salo, T. Nikkari, E. Vartiainen, P. Puska, and F. Gey. 1986. Linoleic acid content in adipose tissue and coronary heart disease. British Medical Journal (Clinical Research ed.) 292 (6533):1423–7. doi: 10.1136/bmj.292.6533.1423.
   PubMedGoogle Scholar
• Saini, R. K., and Y. S. Keum. 2018. Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance - A review. Life Sci 203:255–267. doi: 10.1016/j.lfs.2018.04.049.
   PubMed Web of Science ®Google Scholar
• Serhan, C. N. 2014. Pro-resolving lipid mediators are leads for resolution physiology. Nature 510 (7503):92–101. doi: 10.1038/nature13479.
   PubMed Web of Science ®Google Scholar
• Singer, P., S. Voigt, and W. Gödicke. 1982. Inverse relationship between linoleic acid in serum and in adipose tissue of patients with essential hypertension. Prostaglandins, Leukotrienes and Medicine 9 (6):603–13. doi: 10.1016/0262-1746(82)90018-X.
   PubMedGoogle Scholar
• Sun, S. H., C. C. Chen, S. J. Lin, C. Y. Hong, B. N. Chiang, and G. Y. Sun. 1987. An initial screening of serum lipids and fatty acid profiles of hypertensive and normotensive subjects. Life Sciences 40 (6):527–34. doi: 10.1016/0024-3205(87)90365-1.
   PubMed Web of Science ®Google Scholar
• Tremblay, A. J., J. P. Després, M. E. Piché, A. Nadeau, J. Bergeron, N. Alméras, A. Tremblay, and S. Lemieux. 2004. Associations between the fatty acid content of triglyceride, visceral adipose tissue accumulation, and components of the insulin resistance syndrome. Metabolism 53 (3):310–7. doi: 10.1016/j.metabol.2003.10.011.
   PubMed Web of Science ®Google Scholar
• Tsukamoto, I., and S. Sugawara. 2018. Erratum: Low levels of linoleic acid and α-linolenic acid and high levels of arachidonic acid in plasma phospholipids are associated with hypertension . Biomedical Reports 8 (4):396–76. doi: 10.3892/br.2017.1015.
   PubMed Web of Science ®Google Scholar
• Vafeiadou, K., M. Weech, H. Altowaijri, S. Todd, P. Yaqoob, K. G. Jackson, and J. A. Lovegrove. 2015. Replacement of saturated with unsaturated fats had no impact on vascular function but beneficial effects on lipid biomarkers, E-selectin, and blood pressure: Results from the randomized, controlled Dietary Intervention and VAScular function (DIVAS) study. The American Journal of Clinical Nutrition 102 (1):40–8. doi: 10.3945/ajcn.114.097089.
   PubMed Web of Science ®Google Scholar
• Wang, L., J. E. Manson, J. P. Forman, J. M. Gaziano, J. E. Buring, and H. D. Sesso. 2010. Dietary fatty acids and the risk of hypertension in middle-aged and older women. Hypertension (Dallas, Tex.: 1979) 56 (4):598–604. doi: 10.1161/HYPERTENSIONAHA.110.154187.
   PubMed Web of Science ®Google Scholar
• Wang, S., A. Ma, S. Song, Q. Quan, X. Zhao, and X. Zheng. 2008. Fasting serum free fatty acid composition, waist/hip ratio and insulin activity in essential hypertensive patients. Hypertension Research 31 (4):623–32. doi: 10.1291/hypres.31.623.
   PubMed Web of Science ®Google Scholar
• Willett, W. 2021. Nutritional Epidemiology. 3rd ed. New York:Oxford University Press.
   Google Scholar
• Williams, E. S., A. Baylin, and H. Campos. 2007. Adipose tissue arachidonic acid and the metabolic syndrome in Costa Rican adults. Clinical Nutrition 26 (4):474–82. doi: 10.1016/j.clnu.2007.03.004.
   PubMed Web of Science ®Google Scholar
• Wolters, M., V. Pala, P. Russo, P. Risé, L. A. Moreno, S. De Henauw, K. Mehlig, T. Veidebaum, D. Molnár, M. Tornaritis, et al. 2016. Associations of whole blood n-3 and n-6 polyunsaturated fatty acids with blood pressure in children and adolescents - Results from the IDEFICS/I.Family Cohort. PLoS One 11 (11):e0165981. doi: 10.1371/journal.pone.0165981.
   PubMed Web of Science ®Google Scholar
• Xu, C., and S. A. R. Doi. 2018. The robust error meta-regression method for dose-response meta-analysis. International Journal of Evidence-Based Healthcare 16 (3):138–44. doi: 10.1097/XEB.0000000000000132.
   PubMed Web of Science ®Google Scholar
• Yang, B., F. Ding, J. Yan, X. W. Ye, X. L. Xu, F. L. Wang, D. Li, and W. Yu. 2016. Exploratory serum fatty acid patterns associated with blood pressure in community-dwelling middle-aged and elderly Chinese. Lipids in Health and Disease 15 (1):58. doi: 10.1186/s12944-016-0226-3.
   PubMedGoogle Scholar
• Zec, M. M., A. E. Schutte, C. Ricci, J. Baumgartner, I. M. Kruger, and C. M. Smuts. 2019. Long-chain polyunsaturated fatty acids are associated with blood pressure and hypertension over 10-years in black South African adults undergoing nutritional transition. Foods (Basel, Switzerland) 8 (9):394. doi: 10.3390/foods8090394.
   PubMed Web of Science ®Google Scholar
• Zheng, Z. J., A. R. Folsom, J. Ma, D. K. Arnett, P. G. McGovern, and J. H. Eckfeldt. 1999. Plasma fatty acid composition and 6-year incidence of hypertension in middle-aged adults: The atherosclerosis risk in communities (ARIC) study. American Journal of Epidemiology 150 (5):492–500. doi: 10.1093/oxfordjournals.aje.a010038.
   PubMed Web of Science ®Google Scholar
• Zhang, J., and K. F. Yu. 1998. What’s the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. JAMA 280 (19):1690–1. doi: 10.1001/jama.280.19.1690.
   PubMed Web of Science ®Google Scholar