Modulation of inflammation by phytochemicals to enhance efficacy and reduce toxicity of cancer chemotherapy

References

• Aktepe, O. H., T. K. Şahin, G. Güner, Z. Arik, and Ş. Yalçin. 2021. Lycopene sensitizes the cervical cancer cells to cisplatin via targeting nuclear factor- kappa B (NF-κB) pathway. Turkish Journal of Medical Sciences 51 (1):368–74. doi: 10.3906/sag-2005-413.
   PubMed Web of Science ®Google Scholar
• Ali, B. H., A. Abdelrahman, Y. Al Suleimani, P. Manoj, H. Ali, A. Nemmar, and M. A. Za’abi. 2020. Effect of concomitant treatment of curcumin and melatonin on cisplatin-induced nephrotoxicity in rats. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 131:110761 doi: 10.1016/j.biopha.2020.110761.
   PubMed Web of Science ®Google Scholar
• al-Shabanah, O. A., O. A. Badary, M. N. Nagi, N. M. Al-Gharably, A. C. Al-Rikabi, and A. M. Al-Bekairi. 1998. Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity. Journal of Experimental & Clinical Cancer Research 17 (2):193–8.
   Google Scholar
• Ali, B. H., A. Abdelrahman, Y. Al Suleimani, P. Manoj, H. Ali, A. Nemmar, and M. Al Za’abi. 2020. Effect of concomitant treatment of curcumin and melatonin on cisplatin-induced nephrotoxicity in rats. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 131:110761 doi:10.1016/j.biopha.2020.110761. PMC: 33152924
   PubMed Web of Science ®Google Scholar
• Badary, O. A., A. B. Abdel-Naim, M. H. Abdel-Wahab, and F. M. Hamada. 2000. The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats. Toxicology 143 (3):219–26. doi: 10.1016/S0300-483X(99)00179-1.
   PubMed Web of Science ®Google Scholar
• Badary, O. A., M. N. Nagi, O. A. Al-Shabanah, H. A. Al-Sawaf, M. O. Al-Sohaibani, and A. M. Al-Bekairi. 1997. Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity. Canadian Journal of Physiology and Pharmacology 75 (12):1356–61. doi: 10.1139/y97-169.
   PubMed Web of Science ®Google Scholar
• Banerjee, S., Y. Zhang, S. Ali, M. Bhuiyan, Z. Wang, P. J. Chiao, P. A. Philip, J. Abbruzzese, and F. H. Sarkar. 2005. Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Research 65 (19):9064–72. doi:10.1158/0008-5472.CAN-05-1330. PMID:16204081
   PubMed Web of Science ®Google Scholar
• Banerjee, S., Y. Zhang, Z. Wang, M. Che, P. J. Chiao, J. L. Abbruzzese, and F. H. Sarkar. 2007. In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer. International Journal of Cancer 120 (4):906–17. doi:10.1002/ijc.22332. PMID:17131310
   PubMed Web of Science ®Google Scholar
• Banerjee, S., S. Padhye, A. Azmi, Z. Wang, P. A. Philip, O. Kucuk, F. H. Sarkar, and R. M. Mohammad. 2010. Review on molecular and therapeutic potential of thymoquinone in cancer. Nutrition and Cancer 62 (7):938–46. doi: 10.1080/01635581.2010.509832.
   PubMed Web of Science ®Google Scholar
• Baur, J. A., and D. A. Sinclair. 2006. Therapeutic potential of resveratrol: The in vivo evidence. Nature Reviews. Drug Discovery 5 (6):493–506. doi: 10.1038/nrd2060.
   PubMed Web of Science ®Google Scholar
• Bava, S. V., C. N. Sreekanth, A. K. T. Thulasidasan, N. P. Anto, V. T. Cheriyan, V. T. Puliyappadamba, S. G. Menon, S. D. Ravichandran, and R. J. Anto. 2011. Akt is upstream and MAPKs are downstream of NF-κB in paclitaxel-induced survival signaling events, which are down-regulated by curcumin contributing to their synergism. The International Journal of Biochemistry & Cell Biology 43 (3):331–41. doi:10.1016/j.biocel.2010.09.011. PMID:20883815
   PubMed Web of Science ®Google Scholar
• Bava, S. V., V. T. Puliyappadamba, A. Deepti, A. Nair, D. Karunagaran, and R. J. Anto. 2005. Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization. The Journal of Biological Chemistry 280 (8):6301–8. doi: 10.1074/jbc.M410647200.
   PubMed Web of Science ®Google Scholar
• Bayat Mokhtari, R., N. Baluch, T. S. Homayouni, E. Morgatskaya, S. Kumar, P. Kazemi, and H. Yeger. 2018. The role of Sulforaphane in cancer chemoprevention and health benefits: A mini-review. Journal of Cell Communication and Signaling 12 (1):91–101. doi: 10.1007/s12079-017-0401-y.
   PubMed Web of Science ®Google Scholar
• Bentires-Alj, M., V. Barbu, M. Fillet, A. Chariot, B. Relic, N. Jacobs, J. Gielen, M. P. Merville, and V. Bours. 2003. NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells. Oncogene 22 (1):90–7. doi: 10.1038/sj.onc.1206056.
   PubMed Web of Science ®Google Scholar
• Bertram, J. S. 1999. Carotenoids and gene regulation. Nutrition Reviews 57 (6):182–91. doi: 10.1111/j.1753-4887.1999.tb06941.x.
   PubMed Web of Science ®Google Scholar
• Bhardwaj, A., G. Sethi, S. Vadhan-Raj, C. Bueso-Ramos, Y. Takada, U. Gaur, A. S. Nair, S. Shishodia, and B. B. Aggarwal. 2007. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood 109 (6):2293–302. doi: 10.1182/blood-2006-02-003988.
   PubMed Web of Science ®Google Scholar
• Bharti, A. C., N. Donato, S. Singh, and B. B. Aggarwal. 2003. Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 101 (3):1053–62. doi: 10.1182/blood-2002-05-1320.
   PubMed Web of Science ®Google Scholar
• Boreddy, S. R., and S. K. Srivastava. 2013. Pancreatic cancer chemoprevention by phytochemicals. Cancer Letters 334 (1):86–94. doi: 10.1016/j.canlet.2012.10.020.
   PubMed Web of Science ®Google Scholar
• Casanova, F., J. Quarti, D. C. da Costa, C. A. Ramos, J. L. da Silva, and E. Fialho. 2012. Resveratrol chemosensitizes breast cancer cells to melphalan by cell cycle arrest. Journal of Cellular Biochemistry 113 (8):2586–96. doi: 10.1002/jcb.24134.
   PubMed Web of Science ®Google Scholar
• Chan, J. M., M. J. Stampfer, J. Ma, P. Gann, J. M. Gaziano, M. Pollak, and E. Giovannucci. 2002. Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer. CancerSpectrum Knowledge Environment 94 (14):1099–106. doi: 10.1093/jnci/94.14.1099.
   Google Scholar
• Chehl, N., G. Chipitsyna, Q. Gong, C. J. Yeo, and H. A. Arafat. 2009. Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. HPB : The Official Journal of the International Hepato Pancreato Biliary Association 11 (5):373–81. doi: 10.1111/j.1477-2574.2009.00059.x.
   PubMed Web of Science ®Google Scholar
• Chen, P., M.-D. Hu, X.-F. Deng, and B. Li. 2013. Genistein reinforces the inhibitory effect of Cisplatin on liver cancer recurrence and metastasis after curative hepatectomy. Asian Pacific Journal of Cancer Prevention : APJCP 14 (2):759–64. doi:10.7314/apjcp.2013.14.2.759. PMID:23621233
   PubMedGoogle Scholar
• Chen, L., H. Deng, H. Cui, J. Fang, Z. Zuo, J. Deng, Y. Li, X. Wang, and L. Zhao. 2018. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 9 (6):7204–18. doi: 10.18632/oncotarget.23208.
   PubMedGoogle Scholar
• Chen, T. C., W. Wang, E. B. Golden, S. Thomas, W. Sivakumar, F. M. Hofman, S. G. Louie, and A. H. Schönthal. 2011. Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models. Cancer Letters 302 (2):100–8. doi: 10.1016/j.canlet.2010.11.008.
   PubMed Web of Science ®Google Scholar
• Choudhari, A. S., P. C. Mandave, M. Deshpande, P. Ranjekar, and O. Prakash. 2019. Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice. Frontiers in Pharmacology 10 (:1614 doi: 10.3389/fphar.2019.01614.
   PubMed Web of Science ®Google Scholar
• Colin, D., A. Gimazane, G. Lizard, J.-C. Izard, E. Solary, N. Latruffe, and D. Delmas. 2009. Effects of resveratrol analogs on cell cycle progression, cell cycle associated proteins and 5fluoro-uracil sensitivity in human derived colon cancer cells. International Journal of Cancer 124 (12):2780–8. doi:10.1002/ijc.24264. PMID:19334045
   PubMed Web of Science ®Google Scholar
• Dai, N., R. Ye, Q. He, P. Guo, H. Chen, and Q. Zhang. 2018. Capsaicin and sorafenib combination treatment exerts synergistic anti‑hepatocellular carcinoma activity by suppressing EGFR and PI3K/Akt/mTOR signaling. Oncol Rep 40 (6):3235–48. doi: 10.3892/or.2018.6754.
   PubMed Web of Science ®Google Scholar
• Daker, M., M. Ahmad, and A. S. Khoo. 2012. Quercetin-induced inhibition and synergistic activity with cisplatin - a chemotherapeutic strategy for nasopharyngeal carcinoma cells. Cancer Cell International 12 (1):34 doi: 10.1186/1475-2867-12-34.
   PubMedGoogle Scholar
• Dhandapani, K. M., V. B. Mahesh, and D. W. Brann. 2007. Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors. Journal of Neurochemistry 102 (2):522–38. doi: 10.1111/j.1471-4159.2007.04633.x.
   PubMed Web of Science ®Google Scholar
• Dhima, I., S. Zerikiotis, P. Lekkas, Y. V. Simos, M. Gkiouli, P. Vezyraki, E. Dounousi, V. Ragos, X. Giannakopoulos, D. Baltogiannis, et al. 2019. Curcumin acts as a chemosensitizer for leiomyosarcoma cells in vitro but fails to mediate antioxidant enzyme activity in cisplatin-induced experimental nephrotoxicity in rats. Integrative Cancer Therapies 18:1534735419872811 doi: 10.1177/1534735419872811.
   Web of Science ®Google Scholar
• Díaz-Chávez, J., M. A. Fonseca-Sánchez, E. Arechaga-Ocampo, A. Flores-Pérez, Y. Palacios-Rodríguez, G. Domínguez-Gómez, L. A. Marchat, L. Fuentes-Mera, G. Mendoza-Hernández, P. Gariglio, et al. 2013. Proteomic profiling reveals that resveratrol inhibits HSP27 expression and sensitizes breast cancer cells to doxorubicin therapy. PLoS One 8 (5):e64378 doi: 10.1371/journal.pone.0064378.
   PubMed Web of Science ®Google Scholar
• Dogukan, A., M. Tuzcu, C. A. Agca, H. Gencoglu, N. Sahin, M. Onderci, I. H. Ozercan, N. Ilhan, O. Kucuk, and K. Sahin. 2011. A tomato lycopene complex protects the kidney from cisplatin-induced injury via affecting oxidative stress as well as Bax, Bcl-2, and HSPs expression. Nutrition and Cancer 63 (3):427–34. doi: 10.1080/01635581.2011.535958.
   PubMed Web of Science ®Google Scholar
• Donald, G., K. Hertzer, and G. Eibl. 2012. Baicalein-an intriguing therapeutic phytochemical in pancreatic cancer. Current Drug Targets 13 (14):1772–6. doi: 10.2174/138945012804545470.
   PubMed Web of Science ®Google Scholar
• Dou, J., Z. Wang, L. Ma, B. Peng, K. Mao, C. Li, M. Su, C. Zhou, and G. Peng. 2018. Baicalein and baicalin inhibit colon cancer using two distinct fashions of apoptosis and senescence. Oncotarget 9 (28):20089–102. doi: 10.18632/oncotarget.24015.
   PubMedGoogle Scholar
• Dutta, B., J. E. Park, I. T. Y. Qing, O. L. Kon, and S. K. Sze. 2018. Soy-derived phytochemical genistein modifies chromatome topology to restrict cancer cell proliferation. Proteomics 18 (16):e1700474 doi: 10.1002/pmic.201700474.
   PubMed Web of Science ®Google Scholar
• El-Rayes, B. F., S. Ali, I. F. Ali, P. A. Philip, J. Abbruzzese, and F. H. Sarkar. 2006. Potentiation of the Effect of Erlotinib by Genistein in Pancreatic Cancer: The Role of Akt and Nuclear Factor-κB. Cancer Research 66 (21):10553–9. doi:10.1158/0008-5472.CAN-06-2333.
   PubMed Web of Science ®Google Scholar
• Elmallah, M. I. Y., and O. Micheau. 2019. Epigenetic regulation of TRAIL signaling: Implication for cancer therapy. Cancers (Basel) 11 (6)doi: 10.3390/cancers11060850.
   PubMed Web of Science ®Google Scholar
• Farghaly, M. E., A. A. Khowailed, B. E. Aboulhoda, L. A. Rashed, S. S. Gaber, and H. Ashour. 2021. Thymoquinone potentiated the anticancer effect of cisplatin on hepatic tumorigenesis by modulating tissue oxidative stress and endoplasmic GRP78/CHOP signaling. Nutrition and Cancer :1–10. doi: 10.1080/01635581.2021.1879880.
   Web of Science ®Google Scholar
• Ferreira, A. L., D. M. Salvadori, M. C. Nascimento, N. S. Rocha, C. R. Correa, E. J. Pereira, L. S. Matsubara, B. B. Matsubara, and M. S. Ladeira. 2007. Tomato-oleoresin supplement prevents doxorubicin-induced cardiac myocyte oxidative DNA damage in rats. Mutation Research. 631 (1):26–35. doi: 10.1016/j.mrgentox.2007.04.003.
   PubMed Web of Science ®Google Scholar
• Friedman, J. R., H. E. Perry, K. C. Brown, Y. Gao, J. Lin, C. D. Stevenson, J. D. Hurley, N. A. Nolan, A. T. Akers, Y. C. Chen, et al. 2017. Capsaicin synergizes with camptothecin to induce increased apoptosis in human small cell lung cancers via the calpain pathway. Biochemical Pharmacology 129:54–66. doi: 10.1016/j.bcp.2017.01.004.
   PubMed Web of Science ®Google Scholar
• Fulda, S., and K. M. Debatin. 2004. Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol. Oncogene 23 (40):6702–11. doi: 10.1038/sj.onc.1207630.
   PubMed Web of Science ®Google Scholar
• Garg, A. K., T. A. Buchholz, and B. B. Aggarwal. 2005. Chemosensitization and radiosensitization of tumors by plant polyphenols. Antioxidants & Redox Signaling 7 (11/12):1630–47. doi: 10.1089/ars.2005.7.1630.
   PubMed Web of Science ®Google Scholar
• Gatouillat, G.,. E. Balasse, D. Joseph-Pietras, H. Morjani, and C. Madoulet. 2010. Resveratrol induces cell-cycle disruption and apoptosis in chemoresistant B16 melanoma. Journal of Cellular Biochemistry 110 (4):893–902. doi: 10.1002/jcb.22601.
   PubMed Web of Science ®Google Scholar
• Gerl, R., and D. L. Vaux. 2005. Apoptosis in the development and treatment of cancer. Carcinogenesis 26 (2):263–70. doi: 10.1093/carcin/bgh283.
   PubMed Web of Science ®Google Scholar
• Ghosh, S., and M. S. Hayden. 2012. Celebrating 25 years of NF-κB research. Immunological Reviews 246 (1):5–13. doi: 10.1111/j.1600-065X.2012.01111.x.
   PubMedGoogle Scholar
• Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annual Review of Immunology 16:225–60. doi: 10.1146/annurev.immunol.16.1.225.
   PubMed Web of Science ®Google Scholar
• Goel, A., and B. B. Aggarwal. 2010. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutrition and Cancer 62 (7):919–30. doi: 10.1080/01635581.2010.509835.
   PubMed Web of Science ®Google Scholar
• Golden, E. B., P. Y. Lam, A. Kardosh, K. J. Gaffney, E. Cadenas, S. G. Louie, N. A. Petasis, T. C. Chen, and A. H. Schönthal. 2009. Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors. Blood 113 (23):5927–37. doi: 10.1182/blood-2008-07-171389.
   PubMed Web of Science ®Google Scholar
• Gong, T. T., X. D. Liu, Z. P. Zhan, and Q. J. Wu. 2020. Sulforaphane enhances the cisplatin sensitivity through regulating DNA repair and accumulation of intracellular cisplatin in ovarian cancer cells. Experimental Cell Research 393 (2):112061 doi: 10.1016/j.yexcr.2020.112061.
   PubMed Web of Science ®Google Scholar
• Granados-Principal, S., J. L. Quiles, C. L. Ramirez-Tortosa, P. Sanchez-Rovira, and M. C. Ramirez-Tortosa. 2010. New advances in molecular mechanisms and the prevention of adriamycin toxicity by antioxidant nutrients. Food and Chemical Toxicology 48 (6):1425–38. doi: 10.1016/j.fct.2010.04.007.
   PubMed Web of Science ®Google Scholar
• Gupta, S., K. Hastak, F. Afaq, N. Ahmad, and H. Mukhtar. 2004. Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosis. Oncogene 23 (14):2507–22. doi: 10.1038/sj.onc.1207353.
   PubMed Web of Science ®Google Scholar
• Gupta, S. C., R. Kannappan, S. Reuter, J. H. Kim, and B. B. Aggarwal. 2011. Chemosensitization of tumors by resveratrol. Annals of the New York Academy of Sciences 1215:150–60. doi: 10.1111/j.1749-6632.2010.05852.x.
   PubMed Web of Science ®Google Scholar
• Gupta, S. C., J. H. Kim, S. Prasad, and B. B. Aggarwal. 2010. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Reviews 29 (3):405–34. doi: 10.1007/s10555-010-9235-2.
   PubMed Web of Science ®Google Scholar
• Gupta, S. C., A. B. Kunnumakkara, S. Aggarwal, and B. B. Aggarwal. 2018. Inflammation, a double-edge sword for cancer and other age-related diseases. Frontiers in Immunology 9:2160. doi: 10.3389/fimmu.2018.02160.
   PubMed Web of Science ®Google Scholar
• Gupta, S. C., B. Sung, J. H. Kim, S. Prasad, S. Li, and B. B. Aggarwal. 2013. Multitargeting by turmeric, the golden spice: From kitchen to clinic. Molecular Nutrition & Food Research 57 (9):1510–28. doi: 10.1002/mnfr.201100741.
   PubMed Web of Science ®Google Scholar
• Hadad, N., and R. Levy. 2012. The synergistic anti-inflammatory effects of lycopene, lutein, β-carotene, and carnosic acid combinations via redox-based inhibition of NF-κB signaling. Free Radical Biology & Medicine 53 (7):1381–91. doi: 10.1016/j.freeradbiomed.2012.07.078.
   PubMed Web of Science ®Google Scholar
• Han, S. Z., H. X. Liu, L. Q. Yang, L. D. Cui, and Y. Xu. 2017. Piperine (PP) enhanced mitomycin-C (MMC) therapy of human cervical cancer through suppressing Bcl-2 signaling pathway via inactivating STAT3/NF-κB. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 96:1403–10. doi: 10.1016/j.biopha.2017.11.022.
   PubMed Web of Science ®Google Scholar
• Harikumar, K. B., A. B. Kunnumakkara, G. Sethi, P. Diagaradjane, P. Anand, M. K. Pandey, J. Gelovani, S. Krishnan, S. Guha, and B. B. Aggarwal. 2010. Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer. International Journal of Cancer 127 (2):68. doi: 10.1002/ijc.25041.
   Web of Science ®Google Scholar
• Hasima, N., and B. Ozpolat. 2014. Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer. Cell Death & Disease 5 (11):e1509 doi: 10.1038/cddis.2014.467.
   PubMedGoogle Scholar
• Hazai, E., Z. Bikádi, F. Zsila, and S. F. Lockwood. 2006. Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase. Bioorganic & Medicinal Chemistry 14 (20):6859–67. doi: 10.1016/j.bmc.2006.06.045.
   PubMed Web of Science ®Google Scholar
• He, S., G. Niu, J. Shang, Y. Deng, Z. Wan, C. Zhang, Z. You, and H. Shen. 2017. The oncogenic Golgi phosphoprotein 3 like overexpression is associated with cisplatin resistance in ovarian carcinoma and activating the NF-κB signaling pathway. Journal of Experimental & Clinical Cancer Research 36 (1):137 doi: 10.1186/s13046-017-0607-0.
   PubMed Web of Science ®Google Scholar
• Higgins, C. F. 2007. Multiple molecular mechanisms for multidrug resistance transporters. Nature 446 (7137):749–57. doi: 10.1038/nature05630.
   PubMed Web of Science ®Google Scholar
• Hou, C., L. Lu, Z. Liu, Y. Lian, and J. Xiao. 2021. Resveratrol reduces drug resistance of SCLC cells by suppressing the inflammatory microenvironment and the STAT3/VEGF pathway. FEBS Open Bio. doi: 10.1002/2211-5463.13230.
   Web of Science ®Google Scholar
• Hour, T. C., J. Chen, C. Y. Huang, J. Y. Guan, S. H. Lu, and Y. S. Pu. 2002. Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1/CIP1) and C/EBPbeta expressions and suppressing NF-kappaB activation. The Prostate 51 (3):211–8. doi: 10.1002/pros.10089.
   PubMed Web of Science ®Google Scholar
• Howells, L. M., A. Mitra, and M. M. Manson. 2007. Comparison of oxaliplatin- and curcumin-mediated antiproliferative effects in colorectal cell lines. International Journal of Cancer 121 (1):175–83. doi: 10.1002/ijc.22645.
   PubMed Web of Science ®Google Scholar
• Huh, H. C., S. Y. Lee, S. K. Lee, N. H. Park, and I. S. Han. 2011. Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein. Nutrition and Cancer 63 (7):1095–103. doi: 10.1080/01635581.2011.607548.
   PubMed Web of Science ®Google Scholar
• Ismail, N. I., Othman, I. F. Abas, H. Lajis, N., and R. Naidu. 2019. Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer. International Journal of Molecular Sciences 20 (10):2454. doi: 10.3390/ijms20102454.
   Web of Science ®Google Scholar
• Ivanov, V. N., M. A. Partridge, G. E. Johnson, S. X. Huang, H. Zhou, and T. K. Hei. 2008. Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression. Experimental Cell Research 314 (5):1163–76. doi: 10.1016/j.yexcr.2007.12.012.
   PubMed Web of Science ®Google Scholar
• Jain, A. K., K. Thanki, and S. Jain. 2013. Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: Implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity. Molecular Pharmaceutics 10 (9):3459–74. doi: 10.1021/mp400311j.
   PubMed Web of Science ®Google Scholar
• Jakubowicz-Gil, J.,. R. Paduch, T. Piersiak, K. Głowniak, A. Gawron, and M. Kandefer-Szerszeń. 2005. The effect of quercetin on pro-apoptotic activity of cisplatin in HeLa cells. Biochemical Pharmacology 69 (9):1343–50. doi: 10.1016/j.bcp.2005.01.022.
   PubMed Web of Science ®Google Scholar
• Jewell, C., and N. M. O’Brien. 1999. Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat. British Journal of Nutrition 81 (3):235–42. doi: 10.1017/S0007114599000434.
   PubMed Web of Science ®Google Scholar
• Jiang, Z.-B., C. Xu, W. Wang, Y.-Z. Zhang, J.-M. Huang, Y.-J. Xie, Q.-Q. Wang, X.-X. Fan, X.-J. Yao, C. Xie, et al. 2021. Plumbagin suppresses non-small cell lung cancer progression through downregulating ARF1 and by elevating CD8+ T cells . Pharmacological Research 169:105656. doi: 10.1016/j.phrs.2021.105656.
   PubMed Web of Science ®Google Scholar
• Jo, Y., N. Choi, K. Kim, H.-J. Koo, J. Choi, and H. N. Kim. 2018. Chemoresistance of cancer cells: requirements of tumor microenvironment-mimicking in vitro models in anti-cancer drug development. Theranostics 8 (19):5259–75. doi: 10.7150/thno.29098.
   PubMed Web of Science ®Google Scholar
• Kamat, A. M., S. T. Tharakan, B. Sung, and B. B. Aggarwal. 2009. Curcumin Potentiates the Antitumor Effects of Bacillus Calmette-Guerin against Bladder Cancer through the Downregulation of NF-κB and Upregulation of TRAIL Receptors. Cancer Research 69 (23):8958–66. doi:10.1158/0008-5472.CAN-09-2045.
   PubMed Web of Science ®Google Scholar
• Karimi, G., M. Ramezani, and A. Abdi. 2005. Protective effects of lycopene and tomato extract against doxorubicin-induced cardiotoxicity. Phytotherapy Research 19 (10):912–4. doi: 10.1002/ptr.1746.
   PubMed Web of Science ®Google Scholar
• Karin, M. 1999. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. The Journal of Biological Chemistry 274 (39):27339–42. doi: 10.1074/jbc.274.39.27339.
   PubMed Web of Science ®Google Scholar
• Kazemi, F., I. Karimi, and N. Yousofvand. 2021. Molecular docking study of lignanamides from Cannabis sativa against P-glycoprotein. In Silico Pharmacology 9 (1):6 doi: 10.1007/s40203-020-00066-7.
   PubMedGoogle Scholar
• Khatoon, E., K. Banik, C. Harsha, B. L. Sailo, K. K. Thakur, A. D. Khwairakpam, R. Vikkurthi, T. B. Devi, S. C. Gupta, and A. B. Kunnumakkara. 2020. Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives. Seminars in Cancer Biology. 28:S1044-579x(20)30150-4. doi: 10.1016/j.semcancer.2020.06.014.
   Google Scholar
• Kilic, U., K. Sahin, M. Tuzcu, N. Basak, C. Orhan, B. Elibol-Can, E. Kilic, F. Sahin, and O. Kucuk. 2014. Enhancement of Cisplatin sensitivity in human cervical cancer: epigallocatechin-3-gallate. Frontiers in Nutrition 1:28 doi: 10.3389/fnut.2014.00028.
   PubMedGoogle Scholar
• Kim, J. H., S. C. Gupta, B. Park, V. R. Yadav, and B. B. Aggarwal. 2012. Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-κB and NF-κB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis. Molecular Nutrition & Food Research 56 (3):454–65. doi: 10.1002/mnfr.201100270.
   PubMed Web of Science ®Google Scholar
• Kim, M. K., K. Kim, J. Y. Han, J. M. Lim, and Y. S. Song. 2011. Modulation of inflammatory signaling pathways by phytochemicals in ovarian cancer. Genes & Nutrition 6 (2):109–15. doi: 10.1007/s12263-011-0209-y.
   PubMed Web of Science ®Google Scholar
• Kim, S. Y., Y. J. Lee, E. H. Park, H. K. Yi, D. S. Jo, J. S. Kim, and P. H. Hwang. 2008. Capsaicin induced apoptosis and the enhanced anticancer effect of anticancer drugs in cancer cells. Korean Journal of Pediatrics 51 (3):307–14. doi: 10.3345/kjp.2008.51.3.307.
   Google Scholar
• Ko, J. K., and K. K. Auyeung. 2013. Target-oriented mechanisms of novel herbal therapeutics in the chemotherapy of gastrointestinal cancer and inflammation. Current Pharmaceutical Design 19 (1):48–66. doi: 10.2174/13816128130109.
   PubMed Web of Science ®Google Scholar
• Kubota, T., Y. Uemura, M. Kobayashi, and H. Taguchi. 2003. Combined effects of resveratrol and paclitaxel on lung cancer cells. Anticancer Research 23 (5a):4039–46.
   PubMed Web of Science ®Google Scholar
• Kuhar, M., S. Imran, and N. Singh. 2007. Curcumin and quercetin combined with cisplatin to induce apoptosis in human laryngeal carcinoma Hep-2 cells through the mitochondrial pathway. Journal of Cancer Molecules 3 (4):121–128.
   Google Scholar
• Kunnumakkara, A. B., P. Diagaradjane, P. Anand, K. B. Harikumar, H. B. Kuzhuvelil, A. Deorukhkar, J. Gelovani, S. Guha, S. Krishnan, and B. B. Aggarwal. 2009. Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. International Journal of Cancer 125 (9):2187–97. doi: 10.1002/ijc.24593.
   PubMed Web of Science ®Google Scholar
• Kunnumakkara, A. B., S. Guha, S. Krishnan, P. Diagaradjane, J. Gelovani, and B. B. Aggarwal. 2007. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Research 67 (8):3853–61. doi: 10.1158/0008-5472.Can-06-4257.
   PubMed Web of Science ®Google Scholar
• Kuo, M. T., Z. Liu, Y. Wei, Y. C. Lin-Lee, S. Tatebe, G. B. Mills, and H. Unate. 2002. Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling. Oncogene 21 (13):1945–54. doi: 10.1038/sj.onc.1205117.
   PubMed Web of Science ®Google Scholar
• Kwak, T. W., D. H. Kim, C.-W. Chung, H. M. Lee, C. H. Kim, Y.-I. Jeong, and D. H. Kang. 2013. Synergistic Anticancer Effects of Vorinostat and Epigallocatechin-3-Gallate against HuCC-T1 Human Cholangiocarcinoma Cells. Evidence-Based Complementary and Alternative Medicine : eCAM 2013:185158 doi:10.1155/2013/185158. PMC: 23864881
   PubMed Web of Science ®Google Scholar
• Kweon, S. H., J. H. Song, and T. S. Kim. 2010. Resveratrol-mediated reversal of doxorubicin resistance in acute myeloid leukemia cells via downregulation of MRP1 expression. Biochemical and Biophysical Research Communications 395 (1):104–10. doi: 10.1016/j.bbrc.2010.03.147.
   PubMed Web of Science ®Google Scholar
• La, X., L. Zhang, Z. Li, H. Li, and Y. Yang. 2019. (-)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-κB/miR-155-5p/MDR1 Pathway. Journal of Agricultural and Food Chemistry 67 (9):2510–8. doi: 10.1021/acs.jafc.8b06665.
   PubMed Web of Science ®Google Scholar
• Lan, C. Y., S. Y. Chen, C. W. Kuo, C. C. Lu, and G. C. Yen. 2019. Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells. Journal of Food and Drug Analysis 27 (4):887–96. doi: 10.1016/j.jfda.2019.07.001.
   PubMed Web of Science ®Google Scholar
• Langner, E., M. K. Lemieszek, and W. Rzeski. 2019. Lycopene, sulforaphane, quercetin, and curcumin applied together show improved antiproliferative potential in colon cancer cells in vitro. Journal of Food Biochemistry 43 (4):e12802 doi: 10.1111/jfbc.12802.
   PubMed Web of Science ®Google Scholar
• Lei, C.-S., Y.-C. Hou, M.-H. Pai, M.-T. Lin, and S.-L. Yeh. 2018. Effects of quercetin combined with anticancer drugs on metastasis-associated factors of gastric cancer cells: In vitro and in vivo studies. Journal of Nutritional Biochemistry 51:105–13. doi: 10.1016/j.jnutbio.2017.09.011.
   PubMed Web of Science ®Google Scholar
• Lev-Ari, S., A. Vexler, A. Starr, M. Ashkenazy-Voghera, J. Greif, D. Aderka, and R. Ben-Yosef. 2007. Curcumin augments gemcitabine cytotoxic effect on pancreatic adenocarcinoma cell lines. Cancer Investigation 25 (6):411–8. doi: 10.1080/07357900701359577.
   PubMed Web of Science ®Google Scholar
• Li, Y., F. Ahmed, S. Ali, P. A. Philip, O. Kucuk, and F. H. Sarkar. 2005. Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Cancer Research 65 (15):6934–42. doi: 10.1158/0008-5472.Can-04-4604.
   PubMed Web of Science ®Google Scholar
• Li, Y., K. L. Ellis, S. Ali, B. F. El-Rayes, A. Nedeljkovic-Kurepa, O. Kucuk, P. A. Philip, and F. H. Sarkar. 2004. Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-kappaB in BxPC-3 pancreatic cancer cell line. Pancreas 28 (4):e90–e95. 5. doi: 10.1097/00006676-200405000-00020.
   PubMed Web of Science ®Google Scholar
• Li, Y.-C., S.-M. He, Z.-X. He, M. Li, Y. Yang, J.-X. Pang, X. Zhang, K. Chow, Q. Zhou, W. Duan, et al. 2014. Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells. Cancer Letters 344 (2):239–59. doi: 10.1016/j.canlet.2013.11.001.
   PubMed Web of Science ®Google Scholar
• Lin, Y. H., L. Y. Zhu, Y. Q. Yang, Z. H. Zhang, Q. G. Chen, Y. P. Sun, J. J. Bi, X. M. Luo, Z. H. Ni, and X. B. Wang. 2021. Resveratrol inhibits MUC5AC expression by regulating SPDEF in lung cancer cells. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 89:153601.doi: 10.1016/j.phymed.2021.153601.
   PubMed Web of Science ®Google Scholar
• Liu, H., G. Lee, J. I. Lee, T. G. Ahn, and S. A. Kim. 2019. Effects of genistein on anti-tumor activity of cisplatin in human cervical cancer cell lines. Obstetrics and Gynecology Science 62 (5):322–8. doi: 10.5468/ogs.2019.62.5.322.
   PubMedGoogle Scholar
• Liu, T., L. Zhang, D. Joo, and S. C. Sun. 2017. NF-κB signaling in inflammation. Signal Transduction and Targeted Therapy 2:17023. doi: 10.1038/sigtrans.2017.23.
   PubMed Web of Science ®Google Scholar
• Li, C., Z. Wang, Q. Wang, R. L. Ka Yan Ho, Y. Huang, M. S. S. Chow, C. W. Kei Lam, and Z. Zuo. 2018. Enhanced anti-tumor efficacy and mechanisms associated with docetaxel-piperine combination- in vitro and in vivo investigation using a taxane-resistant prostate cancer model. Oncotarget 9 (3):3338–52. doi: 10.18632/oncotarget.23235.
   PubMedGoogle Scholar
• Li, S., Q. Zhao, B. Wang, S. Yuan, X. Wang, and K. Li. 2018. Quercetin reversed MDR in breast cancer cells through down-regulating P-gp expression and eliminating cancer stem cells mediated by YB-1 nuclear translocation. Phytotherapy Research 32 (8):1530–6. doi: 10.1002/ptr.6081.
   PubMed Web of Science ®Google Scholar
• Luo, T., J. Wang, Y. Yin, H. Hua, J. Jing, X. Sun, M. Li, Y. Zhang, and Y. Jiang. 2010. (-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma. Breast Cancer Research 12 (1):R8 doi: 10.1186/bcr2473.
   PubMed Web of Science ®Google Scholar
• Ma, Y., J. Wang, L. Liu, H. Zhu, X. Chen, S. Pan, X. Sun, and H. Jiang. 2011. Genistein potentiates the effect of arsenic trioxide against human hepatocellular carcinoma: Role of Akt and nuclear factor-κB. Cancer Letters 301 (1):75–84. doi: 10.1016/j.canlet.2010.10.022.
   PubMed Web of Science ®Google Scholar
• Maliakel, D. M., T. V. Kagiya, and C. K. Nair. 2008. Prevention of cisplatin-induced nephrotoxicity by glucosides of ascorbic acid and alpha-tocopherol. Experimental and Toxicologic Pathology : official Journal of the Gesellschaft Fur Toxikologische Pathologie 60 (6):521–7. doi: 10.1016/j.etp.2008.04.015.
   PubMed Web of Science ®Google Scholar
• Malik, A., F. Afaq, S. Sarfaraz, V. M. Adhami, D. N. Syed, and H. Mukhtar. 2005. Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proceedings of the National Academy of Sciences of the United States of America 102 (41):14813–8. doi: 10.1073/pnas.0505870102.
   PubMed Web of Science ®Google Scholar
• Mitra, S., and R. Dash. 2018. Natural Products for the Management and Prevention of Breast Cancer. Evidence-Based Complementary and Alternative Medicine 2018:8324696 doi: 10.1155/2018/8324696.
   PubMed Web of Science ®Google Scholar
• Mohammad, I. S., W. He, and L. Yin. 2020. Insight on Multidrug Resistance and Nanomedicine Approaches to Overcome MDR. Critical Reviews in Therapeutic Drug Carrier Systems 37 (5):473–509. doi: 10.1615/CritRevTherDrugCarrierSyst.2020025052.
   PubMed Web of Science ®Google Scholar
• Mukhtar, H., and N. Ahmad. 2000. Tea polyphenols: Prevention of cancer and optimizing health. The American Journal of Clinical Nutrition 71 (6 Suppl):1698S702S; discussion 703S-4S. doi: 10.1093/ajcn/71.6.1698S.
   PubMed Web of Science ®Google Scholar
• Musial, C., K. Siedlecka-Kroplewska, Z. Kmiec, and M. Gorska-Ponikowska. 2021. Modulation of Autophagy in Cancer Cells by Dietary Polyphenols. Antioxidants (Basel) 10 (1). doi: 10.3390/antiox10010123.
   PubMedGoogle Scholar
• Nessa, M. U., P. Beale, C. Chan, J. Q. Yu, and F. Huq. 2011. Synergism from combinations of cisplatin and oxaliplatin with quercetin and thymoquinone in human ovarian tumour models. Anticancer Research 31 (11):3789–97.
   PubMed Web of Science ®Google Scholar
• Nihal, M., H. Ahsan, I. A. Siddiqui, H. Mukhtar, N. Ahmad, and G. S. Wood. 2009. (-)-Epigallocatechin-3-gallate (EGCG) sensitizes melanoma cells to interferon induced growth inhibition in a mouse model of human melanoma. Cell Cycle (Georgetown, Tex.) 8 (13):2057–63. doi: 10.4161/cc.8.13.8862.
   PubMed Web of Science ®Google Scholar
• Nishikawa, T., T. Nakajima, M. Moriguchi, M. Jo, S. Sekoguchi, M. Ishii, H. Takashima, T. Katagishi, H. Kimura, M. Minami, et al. 2006. A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins. Journal of Hepatology 44 (6):1074–82. doi: 10.1016/j.jhep.2005.11.045.
   PubMed Web of Science ®Google Scholar
• Nosrati, N.,. M. Bakovic, and G. Paliyath. 2017. Molecular Mechanisms and Pathways as Targets for Cancer Prevention and Progression with Dietary Compounds. International Journal of Molecular Sciences 18 (10):2050. doi: 10.3390/ijms18102050.
   PubMed Web of Science ®Google Scholar
• Oh, S. J., O. Kim, J. S. Lee, J. A. Kim, M. R. Kim, H. S. Choi, J. H. Shim, K. W. Kang, and Y. C. Kim. 2010. Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 48 (11):3227–34. doi: 10.1016/j.fct.2010.08.028.
   PubMed Web of Science ®Google Scholar
• Padhye, S., S. Banerjee, A. Ahmad, R. Mohammad, and F. H. Sarkar. 2008. From here to eternity – the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond. Cancer Therapy 6 (b):495–510.
   PubMedGoogle Scholar
• Pang, X., X. Zhang, Y. Jiang, Q. Su, Q. Li, and Z. Li. 2021. Autophagy: Mechanisms and Therapeutic Potential of Flavonoids in Cancer. Biomolecules 11 (2):135. doi: 10.3390/biom11020135.
   Web of Science ®Google Scholar
• Park, B. H., J. E. Lim, H. G. Jeon, S. I. Seo, H. M. Lee, H. Y. Choi, S. S. Jeon, and B. C. Jeong. 2016. Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROS-mediated activation of ERK1/2. Oncotarget 7 (39):63870–86. doi: 10.18632/oncotarget.11563.
   PubMedGoogle Scholar
• Patra, S., B. Pradhan, R. Nayak, C. Behera, K. C. Panda, S. Das, M. Jena, and S. K. Bhutia. 2021. Apoptosis and autophagy modulating dietary phytochemicals in cancer therapeutics: Current evidences and future perspectives. Phytotherapy Research 35 (8):4194–214. doi: 10.1002/ptr.7082.
   PubMed Web of Science ®Google Scholar
• Pianetti, S., S. Guo, K. T. Kavanagh, and G. E. Sonenshein. 2002. Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells. Cancer Research 62 (3):652–5.
   PubMed Web of Science ®Google Scholar
• Pikarsky, E., R. M. Porat, I. Stein, R. Abramovitch, S. Amit, S. Kasem, E. Gutkovich-Pyest, S. Urieli-Shoval, E. Galun, and Y. Ben-Neriah. 2004. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431 (7007):461–6. doi: 10.1038/nature02924.
   PubMed Web of Science ®Google Scholar
• Prasad, S., K. Phromnoi, V. R. Yadav, M. M. Chaturvedi, and B. B. Aggarwal. 2010. Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer. Planta Medica 76 (11):1044–63. doi: 10.1055/s-0030-1250111.
   PubMed Web of Science ®Google Scholar
• Preet, R., P. Mohapatra, D. Das, S. R. Satapathy, T. Choudhuri, M. D. Wyatt, and C. N. Kundu. 2013. Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC. Carcinogenesis 34 (2):277–86. doi: 10.1093/carcin/bgs351.
   PubMed Web of Science ®Google Scholar
• Psotová, J., S. Chlopcíková, P. Miketová, J. Hrbác, and V. Simánek. 2004. Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin. Phytotherapy Research 18 (7):516–21. doi: 10.1002/ptr.1462.
   PubMed Web of Science ®Google Scholar
• Qiao, J., C. Gu, W. Shang, J. Du, W. Yin, M. Zhu, W. Wang, M. Han, and W. Lu. 2011. Effect of green tea on pharmacokinetics of 5-fluorouracil in rats and pharmacodynamics in human cell lines in vitro. Food and Chemical Toxicology 49 (6):1410–5. doi: 10.1016/j.fct.2011.03.033.
   PubMed Web of Science ®Google Scholar
• Qin, X. X., M. Y. Zhang, Y. Y. Han, J. H. Hao, C. J. Liu, and S. X. Fan. 2018. Beneficial Phytochemicals with Anti-Tumor Potential Revealed through Metabolic Profiling of New Red Pigmented Lettuces (Lactuca sativa L.). International Journal of Molecular Sciences 19 (4):1165. doi: 10.3390/ijms19041165.
   Web of Science ®Google Scholar
• Quan, F., C. Pan, Q. Ma, S. Zhang, and L. Yan. 2008. Reversal effect of resveratrol on multidrug resistance in KBv200 cell line. Biomedicine & Pharmacotherapy [Biomedecine & Pharmacotherapie] 62 (9):622–9. doi: 10.1016/j.biopha.2008.07.089.
   PubMed Web of Science ®Google Scholar
• Rao, A. V., N. Fleshner, and S. Agarwal. 1999. Serum and tissue lycopene and biomarkers of oxidation in prostate cancer patients: A case-control study. Nutrition and Cancer 33 (2):159–64. doi: 10.1207/s15327914nc330207.
   PubMed Web of Science ®Google Scholar
• Rezk, Y. A., S. S. Balulad, R. S. Keller, and J. A. Bennett. 2006. Use of resveratrol to improve the effectiveness of cisplatin and doxorubicin: Study in human gynecologic cancer cell lines and in rodent heart. American Journal of Obstetrics and Gynecology 194 (5):e23–e26. 6. doi: 10.1016/j.ajog.2005.11.030.
   PubMedGoogle Scholar
• Rios, A. d O., L. M. G. Antunes, M. de, and L. P. Bianchi. 2009. Bixin and lycopene modulation of free radical generation induced by cisplatin–DNA interaction. Food Chemistry 113 (4):1113–8. doi: 10.1016/j.foodchem.2008.08.084.
   Web of Science ®Google Scholar
• Rizeq, B., I. Gupta, J. Ilesanmi, M. AlSafran, M. M. Rahman, and A. Ouhtit. 2020. The Power of Phytochemicals Combination in Cancer Chemoprevention. Journal of Cancer 11 (15):4521–33. doi: 10.7150/jca.34374.
   PubMed Web of Science ®Google Scholar
• Rong, Y., L. Huang, K. Yi, H. Chen, S. Liu, W. Zhang, C. Yuan, X. Song, and F. Wang. 2020. Co-administration of sulforaphane and doxorubicin attenuates breast cancer growth by preventing the accumulation of myeloid-derived suppressor cells. Cancer Letters 493:189–96. doi: 10.1016/j.canlet.2020.08.041.
   PubMed Web of Science ®Google Scholar
• Ryan, K. M., M. K. Ernst, N. R. Rice, and K. H. Vousden. 2000. Role of NF-kappaB in p53-mediated programmed cell death. Nature 404 (6780):892–7. doi: 10.1038/35009130.
   PubMed Web of Science ®Google Scholar
• Sahin, K., N. Sahin, and O. Kucuk. 2010. Lycopene and chemotherapy toxicity. Nutrition and Cancer 62 (7):988–95. doi: 10.1080/01635581.2010.509838.
   PubMed Web of Science ®Google Scholar
• Sahin, K., M. Tuzcu, N. Basak, B. Caglayan, U. Kilic, F. Sahin, and O. Kucuk. 2012. Sensitization of Cervical Cancer Cells to Cisplatin by Genistein: The Role of NFκB and Akt/mTOR Signaling Pathways. Journal of Oncology 2012:1–6. doi: 10.1155/2012/461562.
   Google Scholar
• Sahin, K., M. Tuzcu, H. Gencoglu, A. Dogukan, M. Timurkan, N. Sahin, A. Aslan, and O. Kucuk. 2010. Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats. Life Sciences. 87 (7-8):240–5. doi: 10.1016/j.lfs.2010.06.014.
   PubMed Web of Science ®Google Scholar
• Sahin, K., M. Tuzcu, N. Sahin, S. Ali, and O. Kucuk. 2010. Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 48 (10):2670–4. doi: 10.1016/j.fct.2010.06.038.
   PubMed Web of Science ®Google Scholar
• Sahin, K., E. Yenice, B. Bilir, C. Orhan, M. Tuzcu, N. Sahin, I. H. Ozercan, N. Kabil, B. Ozpolat, and O. Kucuk. 2019. Genistein prevents development of spontaneous ovarian cancer and inhibits tumor growth in hen model. Cancer Prevention Research (Philadelphia, PA.) 12 (3):135–46. doi: 10.1158/1940-6207.Capr-17-0289.
   PubMed Web of Science ®Google Scholar
• Sahin, K., E. Yenice, M. Tuzcu, C. Orhan, C. Mizrak, I. H. Ozercan, N. Sahin, B. Yilmaz, B. Bilir, B. Ozpolat, et al. 2018. Lycopene protects against spontaneous ovarian cancer formation in laying hens. Journal of Cancer Prevention 23 (1):25–36. doi: 10.15430/JCP.2018.23.1.25.
   PubMed Web of Science ®Google Scholar
• Salehi, B., A. P. Mishra, M. Nigam, B. Sener, M. Kilic, M. Sharifi-Rad, P. V. T. Fokou, N. Martins, and J. Sharifi-Rad. 2018. Resveratrol: A double-edged sword in health benefits. Biomedicines 6 (3):91. doi: 10.3390/biomedicines6030091.
   Web of Science ®Google Scholar
• Scandlyn, M. J., E. C. Stuart, T. J. Somers-Edgar, A. R. Menzies, and R. J. Rosengren. 2008. A new role for tamoxifen in oestrogen receptor-negative breast cancer when it is combined with epigallocatechin gallate. British Journal of Cancer 99 (7):1056–63. doi:10.1038/sj.bjc.6604634.
   PubMed Web of Science ®Google Scholar
• Schirrmacher, V. 2019. From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review). International Journal of Oncology 54 (2):407–19. doi: 10.3892/ijo.2018.4661.
   PubMed Web of Science ®Google Scholar
• Sendão, M. C., E. B. Behling, R. A. dos Santos, L. M. Antunes, M. de, and L. Pires Bianchi. 2006. Comparative effects of acute and subacute lycopene administration on chromosomal aberrations induced by cisplatin in male rats. Food and Chemical Toxicology. 44 (8):1334–9. doi: 10.1016/j.fct.2006.02.010.
   PubMed Web of Science ®Google Scholar
• Shankar, S., S. Ganapathy, Q. Chen, and R. K. Srivastava. 2008. Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis. Molecular Cancer 7:16 doi:10.1186/1476-4598-7-16. PMC: 18226269
   PubMed Web of Science ®Google Scholar
• Shen, M., T. H. Chan, and Q. P. Dou. 2012. Targeting tumor ubiquitin-proteasome pathway with polyphenols for chemosensitization. Anti-Cancer Agents in Medicinal Chemistry 12 (8):891–901. doi: 10.2174/187152012802649978.
   PubMed Web of Science ®Google Scholar
• Shimeda, Y., Y. Hirotani, Y. Akimoto, K. Shindou, Y. Ijiri, T. Nishihori, and K. Tanaka. 2005. Protective effects of capsaicin against cisplatin-induced nephrotoxicity in rats. Biological and Pharmaceutical Bulletin. 28 (9):1635–8. doi: 10.1248/bpb.28.1635.
   PubMed Web of Science ®Google Scholar
• Singh, S. K., T. Apata, J. B. Gordetsky, and R. Singh. 2019. Docetaxel combined with thymoquinone induces apoptosis in prostate cancer cells via inhibition of the PI3K/AKT signaling pathway. Cancers (Basel) 11 (9). doi: 10.3390/cancers11091390.
   Web of Science ®Google Scholar
• Solomon, L. A., S. Ali, S. Banerjee, A. R. Munkarah, R. T. Morris, and F. H. Sarkar. 2008. Sensitization of ovarian cancer cells to cisplatin by genistein: The role of NF-kappaB. Journal of Ovarian Research 1 (1):9 doi: 10.1186/1757-2215-1-9.
   PubMed Web of Science ®Google Scholar
• Stearns, M. E., M. D. Amatangelo, D. Varma, C. Sell, and S. M. Goodyear. 2010. Combination therapy with epigallocatechin-3-gallate and doxorubicin in human prostate tumor modeling studies: Inhibition of metastatic tumor growth in severe combined immunodeficiency mice. Am J Pathol 177 (6):3169–79. doi: 10.2353/ajpath.2010.100330.
   PubMed Web of Science ®Google Scholar
• Sun, C. Y., Q. Y. Zhang, G. J. Zheng, and B. Feng. 2019. Phytochemicals: Current strategy to sensitize cancer cells to cisplatin. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 110:518–27. doi: 10.1016/j.biopha.2018.12.010.
   PubMed Web of Science ®Google Scholar
• Teiten, M. H., S. Eifes, M. Dicato, and M. Diederich. 2010. Curcumin-the paradigm of a multi-target natural compound with applications in cancer prevention and treatment. Toxins 2 (1):128–62. doi: 10.3390/toxins2010128.
   PubMed Web of Science ®Google Scholar
• Ting, C. Y., H. E. Wang, C. C. Yu, H. C. Liu, Y. C. Liu, and I. T. Chiang. 2015. Curcumin Triggers DNA damage and inhibits expression of DNA repair proteins in human lung cancer cells. Anticancer Research 35 (7):3867–73.
   PubMed Web of Science ®Google Scholar
• Ulu, R., A. Dogukan, M. Tuzcu, H. Gencoglu, M. Ulas, N. Ilhan, I. Muqbil, R. M. Mohammad, O. Kucuk, and K. Sahin. 2012. Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 50 (5):1675–9. doi: 10.1016/j.fct.2012.02.082.
   PubMed Web of Science ®Google Scholar
• Varoni, E. M., A. F. Lo Faro, J. Sharifi-Rad, and M. Iriti. 2016. Anticancer molecular mechanisms of resveratrol. Frontiers in Nutrition 3:8 doi: 10.3389/fnut.2016.00008.
   PubMed Web of Science ®Google Scholar
• Venkatraman, M., R. J. Anto, A. Nair, M. Varghese, and D. Karunagaran. 2005. Biological and chemical inhibitors of NF-kappaB sensitize SiHa cells to cisplatin-induced apoptosis. Mol Carcinog 44 (1):51–9. doi: 10.1002/mc.20116.
   PubMed Web of Science ®Google Scholar
• Vinod, B. S., J. Antony, H. H. Nair, V. T. Puliyappadamba, M. Saikia, S. S. Narayanan, A. Bevin, and R. J. Anto. 2013. Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil. Cell Death & Disease 4 (2):e505. doi: 10.1038/cddis.2013.26.
   PubMedGoogle Scholar
• Vinod, B. S., T. T. Maliekal, and R. J. Anto. 2013. Phytochemicals as chemosensitizers: From molecular mechanism to clinical significance. Antioxid Redox Signal 18 (11):1307–48. doi: 10.1089/ars.2012.4573.
   PubMed Web of Science ®Google Scholar
• Wang, C. Y., J. C. Cusack, Jr., R. Liu, and A. S. Baldwin. Jr. 1999. Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nature Medicine 5 (4):412–7. doi: 10.1038/7410.
   PubMed Web of Science ®Google Scholar
• Wang, C. Y., M. W. Mayo, and A. S. Baldwin. Jr. 1996. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB. Science (New York, N.Y.) 274 (5288):784–7. doi: 10.1126/science.274.5288.784.
   PubMed Web of Science ®Google Scholar
• Wu, H., Y. Xin, Y. Xiao, and J. Zhao. 2012. Low-dose docetaxel combined with (-)-epigallocatechin-3-gallate inhibits angiogenesis and tumor growth in nude mice with gastric cancer xenografts. Cancer Biotherapy & Radiopharmaceuticals 27 (3):204–9. doi: 10.1089/cbr.2011.1103.
   PubMed Web of Science ®Google Scholar
• Wu, H., Y. Xin, C. Xu, and Y. Xiao. 2012. Capecitabine combined with (-)-epigallocatechin-3-gallate inhibits angiogenesis and tumor growth in nude mice with gastric cancer xenografts. Experimental and Therapeutic Medicine 3 (4):650–4. doi: 10.3892/etm.2012.448.
   PubMed Web of Science ®Google Scholar
• Wu, B., Q. Zhang, W. Shen, and J. Zhu. 2008. Anti-proliferative and chemosensitizing effects of luteolin on human gastric cancer AGS cell line. Molecular and Cellular Biochemistry 313 (1-2):125–32. doi: 10.1007/s11010-008-9749-x.
   PubMed Web of Science ®Google Scholar
• Xia, Y., S. Shen, and I. M. Verma. 2014. NF-κB, an active player in human cancers. Cancer Immunology Research 2 (9):823–30. doi: 10.1158/2326-6066.CIR-14-0112.
   PubMed Web of Science ®Google Scholar
• Xue, D., S. T. Pan, X. Zhou, F. Ye, Q. Zhou, F. Shi, F. He, H. Yu, and J. Qiu. 2020. Plumbagin enhances the anticancer efficacy of cisplatin by increasing intracellular ros in human tongue squamous cell carcinoma. Oxidative Medicine and Cellular Longevity 2020:5649174 doi: 10.1155/2020/5649174.
   PubMed Web of Science ®Google Scholar
• Yang, M. D., Y. Sun, W. J. Zhou, X. Z. Xie, Q. M. Zhou, Y. Y. Lu, and S. B. Su. 2021. Resveratrol enhances inhibition effects of cisplatin on cell migration and invasion and tumor growth in breast cancer MDA-MB-231 cell models in vivo and in vitro. Molecules 26 (8)2204. doi: 10.3390/molecules2608:.
   PubMed Web of Science ®Google Scholar
• Yi, X., L. Lou, J. Wang, J. Xiong, and S. Zhou. 2021. Honokiol antagonizes doxorubicin resistance in human breast cancer via miR-188-5p/FBXW7/c-Myc pathway. Cancer Chemother Pharmacol 87 (5):647–56. doi: 10.1007/s00280-021-04238-w.
   PubMed Web of Science ®Google Scholar
• Zhang, L. X., R. V. Cooney, and J. S. Bertram. 1991. Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: Relationship to their cancer chemopreventive action. Carcinogenesis 12 (11):2109–14. doi: 10.1093/carcin/12.11.2109.
   PubMed Web of Science ®Google Scholar
• Zhang, B., Z. L. Shi, B. Liu, X. B. Yan, J. Feng, and H. M. Tao. 2010. Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: The role of Akt and nuclear factor-kappaB. Anti-Cancer Drugs 21 (3):288–96. doi: 10.1097/CAD.0b013e328334da17.
   PubMed Web of Science ®Google Scholar
• Zhang, S., Y. Wang, Z. Chen, S. Kim, S. Iqbal, A. Chi, C. Ritenour, Y. A. Wang, O. Kucuk, and D. Wu. 2013. Genistein enhances the efficacy of cabazitaxel chemotherapy in metastatic castration-resistant prostate cancer cells. The Prostate 73 (15):1681–9. doi: 10.1002/pros.22705.
   PubMed Web of Science ®Google Scholar
• Zhang, J., Y. Zhang, W. Shen, R. Fu, Z. Ding, Y. Zhen, and Y. Wan. 2019. Cytological effects of honokiol treatment and its potential mechanism of action in non-small cell lung cancer. Biomedicine & Pharmacotherapy. 117:109058. doi: 10.1016/j.biopha.2019.109058.
   PubMed Web of Science ®Google Scholar
• Zhou, C., W. Han, P. Zhang, M. Cai, D. Wei, and C. Zhang. 2008. Lycopene from tomatoes partially alleviates the bleomycin-induced experimental pulmonary fibrosis in rats. Nutrition Research. 28 (2):122–30. doi: 10.1016/j.nutres.2007.12.008.
   PubMed Web of Science ®Google Scholar
• Zhu, H., H. Luo, W. Zhang, Z. Shen, X. Hu, and X. Zhu. 2016. Molecular mechanisms of cisplatin resistance in cervical cancer. Drug Design, Development and Therapy 10:1885–95. doi: 10.2147/dddt.S106412.
   PubMed Web of Science ®Google Scholar
• Zubair, H., S. Azim, A. Ahmad, M. A. Khan, G. K. Patel, S. Singh, and A. P. Singh. 2017. Cancer chemoprevention by phytochemicals: Nature’s healing touch. Molecules 22 (3):395. doi: 10.3390/molecules22030395.
   Web of Science ®Google Scholar