Latest developments in food-grade delivery systems for probiotics: A systematic review

References

• Afzaal, M., F. Saeed, M. U. Arshad, M. T. Nadeem, M. Saeed, and T. Tufail. 2019. The effect of encapsulation on the stability of probiotic bacteria in ice cream and simulated gastrointestinal conditions. Probiotics and Antimicrobial Proteins 11 (4):1348–54. doi: 10.1007/s12602-018-9485-9.
   PubMed Web of Science ®Google Scholar
• Ajlouni, S., C. S. Ranadheera, and E. L. Chua. 2021. Encapsulation increases the in vitro bioaccessibility of probiotics in yoghurt. International Journal of Dairy Technology 74 (1):118–27. doi: 10.1111/1471-0307.12746.
   Web of Science ®Google Scholar
• Almeida, I. F., A. R. Fernandes, L. Fernandes, M. R. Pena Ferreira, P. C. Costa, and M. F. Bahia. 2008. Moisturizing effect of oleogel/hydrogel mixtures. Pharmaceutical Development and Technology 13 (6):487–94. doi: 10.1080/10837450802282447.
   PubMed Web of Science ®Google Scholar
• Anselmo, A. C., and S. Mitragotri. 2017. Impact of particle elasticity on particle-based drug delivery systems. Advanced Drug Delivery Reviews 108:51–67. doi: 10.1016/j.addr.2016.01.007.
   PubMed Web of Science ®Google Scholar
• Arora, V., G. Singh, I. O-Sullivan, K. G. Ma, A. N. Anbazhagan, E. G. Votta-Velis, B. Bruce, R. Richard, A. J. van Wijnen, and H. J. Im. 2021. Gut-microbiota modulation: The impact of thegut-microbiotaon osteoarthritis. Gene 785:145619. doi: 10.1016/j.gene.2021.145619.
   PubMed Web of Science ®Google Scholar
• Ashoori, Y., M. Mohkam, R. Heidari, S. N. Abootalebi, S. M. Mousavi, S. A. Hashemi, N. Golkar, and A. Gholami. 2020. Development and in vivo characterization of probiotic lysate-treated chitosan nanogel as a novel biocompatible formulation for wound healing. BioMed Research International 2020:8868618. doi: 10.1155/2020/8868618.
   PubMed Web of Science ®Google Scholar
• Behera, B., S. S. Sagiri, V. K. Singh, K. Pal, and A. Anis. 2014. Mechanical properties and delivery of drug/probiotics from starch and non-starch based novel bigels: A comparative study. Starch - Stärke 66 (9–10):865–79. doi: 10.1002/star.201400045.
   Web of Science ®Google Scholar
• Beldarrain-Iznaga, T., R. Villalobos-Carvajal, E. Sevillano-Armesto, and J. Leiva-Vega. 2021. Functional properties of lactobacillus casei C24 improved by microencapsulation using multilayer double emulsion. Food Research International (Ottawa, ON) 141:110136. doi: 10.1016/j.foodres.2021.110136.
   PubMed Web of Science ®Google Scholar
• Biagioli, M., A. Carino, C. D. Giorgio, S. Marchiano, M. Bordoni, R. Roselli, E. Distrutti, and S. Fiorucci. 2020. Discovery of a novel multi-strains probiotic formulation with improved efficacy toward intestinal inflammation. Nutrients 12 (7):1945. doi: 10.3390/nu12071945.
   PubMed Web of Science ®Google Scholar
• Bollom, M. A., S. Clark, and N. C. Acevedo. 2021. Edible lecithin, stearic acid, and whey protein bigels enhance survival of probiotics during in vitro digestion. Food Bioscience 39:100813. doi: 10.1016/j.fbio.2020.100813.
   Web of Science ®Google Scholar
• Canga, E. M., and F. C. Dudak. 2021. Improved digestive stability of probiotics encapsulated within poly(vinyl alcohol)/cellulose acetate hybrid fibers. Carbohydrate polymers 264:117990. doi: 10.1016/j.carbpol.2021.117990.
   PubMed Web of Science ®Google Scholar
• Cavalheiro, C. P., C. Ruiz-Capillas, A. M. Herrero, and T. Pintado. 2021. Dry-fermented sausages inoculated with Enterococcus faecium CECT 410 as free cells or in alginate beads. Lebensmittel-Wissenschaft und -Technologie- Food Science and Technology 139:110561. doi: 10.1016/j.lwt.2020.110561.
   Web of Science ®Google Scholar
• Chen, B. Y., X. Z. Lin, X. J. Lin, W. X. Li, B. D. Zheng, and Z. G. He. 2020. Pectin-microfibrillated cellulose microgel: Effects on survival of lactic acid bacteria in a simulated gastrointestinal tract. Int J Biol Macromol 158:826–836. doi: 10.1016/j.ijbiomac.2020.04.161.
   PubMed Web of Science ®Google Scholar
• da Silva, M. N., B. L. Tagliapietra, and N. S. P. D. Richards. 2021. Encapsulation, storage viability, and consumer acceptance of probiotic butter. Lebensmittel-Wissenschaft und -Technologie- Food Science and Technology 139:110536. doi: 10.1016/j.lwt.2020.110536.
   Web of Science ®Google Scholar
• Diep, E., and J. D. Schiffman. 2021. Encapsulating bacteria in alginate-based electrospun nanofibers. Biomaterials Science 9 (12):4364–73. doi: 10.1039/d0bm02205e.
   PubMed Web of Science ®Google Scholar
• Duman, D., and A. Karadag. 2021. Inulin added electrospun composite nanofibres by electrospinning for the encapsulation of probiotics: Characterisation and assessment of viability during storage and simulated gastrointestinal digestion. International Journal of Food Science & Technology 56 (2):927–35. doi: 10.1111/ijfs.14744.
   Web of Science ®Google Scholar
• Ebrahimnejad, P., M. Khavarpour, and S. Khalilid. 2017. Survival of Lactobacillus Acidophilus as probiotic bacteria using chitosan nanoparticles. International Journal of Engineering 30 (4):456–63. doi: 10.5829/idosi.ije.2017.30.04a.01.
   Web of Science ®Google Scholar
• Fasolin, L. H., A. J. Martins, M. A. Cerqueira, and A. A. Vicente. 2021. Modulating process parameters to change physical properties of bigels for food applications. Food Structure 28:100173. doi: 10.1016/j.foostr.2020.100173.
   Google Scholar
• Feng, K., R. M. Huang, R. Q. Wu, Y. S. Wei, M. H. Zong, R. J. Linhardt, and H. Wu. 2020. A novel route for double-layered encapsulation of probiotics with improved viability under adverse conditions. Food Chemistry 310:125977. doi: 10.1016/j.foodchem.2019.125977.
   PubMed Web of Science ®Google Scholar
• Frakolaki, G., V. Giannou, E. Topakas, and C. Tzia. 2021. Effect of various encapsulating agents on the beads’ morphology and the viability of cells during BB-12 encapsulation through extrusion. Journal of Food Engineering 294:110423. doi: 10.1016/j.jfoodeng.2020.110423.
   Web of Science ®Google Scholar
• Gaziano, R., S. Sabbatini, E. Roselletti, S. Perito, and C. Monari. 2020. Saccharomyces cerevisiae-based probiotics as novel antimicrobial agents to prevent and treat vaginal infections. Frontiers in Microbiology 11:718. doi: 10.3389/fmicb.2020.00718.
   PubMed Web of Science ®Google Scholar
• Gómez-Guillén, M. C., and M. P. Montero. 2021. Enhancement of oral bioavailability of natural compounds and probiotics by mucoadhesive tailored biopolymer-based nanoparticles: A review. Food Hydrocolloids 118:106772. doi: 10.1016/j.foodhyd.2021.106772.
   Web of Science ®Google Scholar
• Han, C., Y. Xiao, E. Liu, Z. Su, X. Meng, and B. Liu. 2020. Preparation of ca-alginate-whey protein isolate microcapsules for protection and delivery of L. bulgaricus and L. paracasei. International Journal of Biological Macromolecules 163:1361–8. doi: 10.1016/j.ijbiomac.2020.07.247.
   PubMed Web of Science ®Google Scholar
• He, C., I. Sampers, D. Van de Walle, K. Dewettinck, and K. Raes. 2021. Encapsulation of Lactobacillus in low-methoxyl pectin-based microcapsules stimulates biofilm formation: Enhanced resistances to heat shock and simulated gastrointestinal digestion. Journal of Agricultural and Food Chemistry 69 (22):6281–90. doi: 10.1021/acs.jafc.1c00719.
   PubMed Web of Science ®Google Scholar
• Heumann, A., A. Assifaoui, D. D. Barreira, C. Thomas, R. Briandet, J. Laurent, L. Beney, P. Lapaquette, J. Guzzo, and A. Rieu. 2020. Intestinal release of biofilm-like microcolonies encased in calcium-pectinate beads increases probiotic properties of Lacticaseibacillus paracasei. NPJ Biofilms and Microbiomes 6 (1):44. doi: 10.1038/s41522-020-00159-3.
   PubMed Web of Science ®Google Scholar
• Holkem, A. T., and C. S. Favaro-Trindade. 2020. Potential of solid lipid microparticles covered by the protein-polysaccharide complex for protection of probiotics and proanthocyanidin-rich cinnamon extract. Food Research International (Ottawa, ON) 136:109520. doi: 10.1016/j.foodres.2020.109520.
   PubMed Web of Science ®Google Scholar
• Huang, R. M., K. Feng, S. F. Li, M. H. Zong, H. Wu, and S. Y. Han. 2021. Enhanced survival of probiotics in the electrosprayed microcapsule by addition of fish oil. Journal of Food Engineering 307:110650. doi: 10.1016/j.jfoodeng.2021.110650.
   Web of Science ®Google Scholar
• Jia, S., K. Zhou, R. Pan, J. Wei, Z. Liu, and Y. Xu. 2020. Oral immunization of carps with chitosan-alginate microcapsule containing probiotic expressing spring viremia of carp virus (SVCV) G protein provides effective protection against SVCV infection. Fish & Shellfish Immunology 105:327–9. doi: 10.1016/j.fsi.2020.07.052.
   PubMed Web of Science ®Google Scholar
• Judkins, T. C., D. L. Archer, D. C. Kramer, and R. J. Solch. 2020. Probiotics, nutrition, and the small intestine. Current Gastroenterology Reports 22 (1):2. doi: 10.1007/s11894-019-0740-3.
   PubMedGoogle Scholar
• Khalighi, A., R. Behdani, and S. Kouhestani. 2016. Probiotics: A comprehensive review of their classification, mode of action and role in human nutrition. In Probiotics and prebiotics in human nutrition and health, ed. V. Rao and L. Rao, 19–40. Rijeka, Croatia: InTech Inc.
   Google Scholar
• Kong, Y., K. J. Olejar, S. L. W. On, and V. Chelikani. 2020. The potential of Lactobacillus spp. For modulating oxidative stress in the gastrointestinal tract. Antioxidants 9 (7):610. doi: 10.3390/antiox9070610.
   Web of Science ®Google Scholar
• Kumar, A., M. Gulati, S. K. Singh, K. Gowthamarajan, R. Prashar, D. Mankotia, J. P. Gupta, M. Banerjee, S. Sinha, A. Awasthi, et al. 2020. Effect of co-administration of probiotics with guar gum, pectin and eudragit S100 based colon targeted mini tablets containing 5-Fluorouracil for site specific release. Journal of Drug Delivery Science and Technology 60:102004. doi: 10.1016/j.jddst.2020.102004.
   Web of Science ®Google Scholar
• Lehtoranta, L., S. Latvala, and M. J. Lehtinen. 2020. Role of probiotics in stimulating the immune system in viral respiratory tract infections: A narrative review. Nutrients 12 (10):3163. doi: 10.3390/nu12103163.
   PubMed Web of Science ®Google Scholar
• Lillo-Pérez, S., M. Guerra-Valle, P. Orellana-Palma, and G. Petzold. 2021. Probiotics in fruit and vegetable matrices: Opportunities for nondairy consumers. Lebensmittel-Wissenschaft und -Technologie- Food Science and Technology 151:112106. doi: 10.1016/j.lwt.2021.112106.
   Web of Science ®Google Scholar
• Lipan, L., B. Rusu, E. Sendra, F. Hernandez, L. Vazquez-Araujo, D. C. Vodnar, and A. A. Carbonell-Barrachina. 2020. Spray drying and storage of probiotic-enriched almond milk: Probiotic survival and physicochemical properties. Journal of the Science of Food and Agriculture 100 (9):3697–708. doi: 10.1002/jsfa.10409.
   PubMed Web of Science ®Google Scholar
• Liu, Y., Y. Y. Sheng, Q. Q. Pan, Y. Z. Xue, L. L. Yu, F. W. Tian, J. X. Zhao, H. Zhang, Q. X. Zhai, and W. Chen. 2020. Identification of the key physiological characteristics of Lactobacillus plantarum strains for ulcerative colitis alleviation. Food & Function 11 (2):1279–91. doi: 10.1039/c9fo02935d.
   PubMed Web of Science ®Google Scholar
• Ma, J. G., C. Xu, H. L. Yu, Z. B. Feng, W. Yu, L. Y. Gu, Z. J. Liu, L. J. Chen, Z. M. Jiang, and J. C. Hou. 2021. Electro-encapsulation of probiotics in gum arabic-pullulan blend nanofibres using electrospinning technology. Food Hydrocolloids 111:106381. doi: 10.1016/j.foodhyd.2020.106381.
   Web of Science ®Google Scholar
• McClements, D. J. 2020. Advances in nanoparticle and microparticle delivery systems for increasing the dispersibility, stability, and bioactivity of phytochemicals. Biotechnology Advances 38:107287. doi: 10.1016/j.biotechadv.2018.08.004.
   PubMed Web of Science ®Google Scholar
• Mendes, A. C., and I. S. Chronakis. 2021. Electrohydrodynamic encapsulation of probiotics: A review. Food Hydrocolloids 117:106688. doi: 10.1016/j.foodhyd.2021.106688.
   Web of Science ®Google Scholar
• Minj, J., P. Chandra, C. Paul, and R. K. Sharma. 2021. Bio-functional properties of probiotic Lactobacillus: Current applications and research perspectives. Critical Reviews in Food Science and Nutrition 61 (13):2207–24. doi: 10.1080/10408398.2020.1774496.
   PubMed Web of Science ®Google Scholar
• Mojaveri, S. J., S. F. Hosseini, and A. Gharsallaoui. 2020. Viability improvement of Bifidobacterium animalis Bb12 by encapsulation in chitosan/poly(vinyl alcohol) hybrid electrospun fiber mats. Carbohydrate Polymers 241:116278. doi: 10.1016/j.carbpol.2020.116278.
   PubMed Web of Science ®Google Scholar
• Neto, J. H. P. L., M. C. G. dos Santos, K. S. Leite, L. A. da Silva, M. I. F. Campos, E. S. da Silveira, J. B. S. Amaral, M. S. Madruga, A. L. M. Braga, and H. R. Cardarelli. 2021. Development and characterization of Lactobacillus acidophilus (LA-3) microparticles with reducing substances and its addition to Reino cheese. Lebensmittel-Wissenschaft und -Technologie- Food Science and Technology 143:111083. doi: 10.1016/j.lwt.2021.111083.
   Web of Science ®Google Scholar
• Novin, D., M. Seifan, A. Ebrahiminezhad, and A. Berenjian. 2021. The effect of iron oxide nanoparticles on Lactobacillus acidophilus growth at pH 4. Bioprocess and Biosystems Engineering 44 (1):39–45. doi: 10.1007/s00449-020-02417-2.
   PubMedGoogle Scholar
• Oak, S. J., and R. Jha. 2019. The effects of probiotics in lactose intolerance: A systematic review. Critical Reviews in Food Science and Nutrition 59 (11):1675–83. doi: 10.1080/10408398.2018.1425977.
   PubMed Web of Science ®Google Scholar
• Pandey, P., S. Mettu, H. N. Mishra, M. Ashokkumar, and G. J. O. Martin. 2021. Multilayer co-encapsulation of probiotics and γ-amino butyric acid (GABA) using ultrasound for functional food applications. Lebensmittel-Wissenschaft und -Technologie- Food Science and Technology 146:111432. doi: 10.1016/j.lwt.2021.111432.
   Web of Science ®Google Scholar
• Patarroyo, J. L., E. Fonseca, J. Cifuentes, F. Salcedo, J. C. Cruz, and L. H. Reyes. 2021. Gelatin-graphene oxide nanocomposite hydrogels for Kluyveromyces lactis encapsulation: Potential applications in probiotics and bioreactor packings. Biomolecules 11 (7):922. doi: 10.3390/biom11070922.
   PubMed Web of Science ®Google Scholar
• Patarroyo, J. L., J. S. Florez-Rojas, D. Pradilla, J. D. Valderrama-Rincon, J. C. Cruz, and L. H. Reyes. 2020. Formulation and characterization of gelatin-based hydrogels for the encapsulation of Kluyveromyces lactis-applications in packed-bed reactors and probiotics delivery in humans. Polymers 12 (6):1287. doi: 10.3390/polym12061287.
   PubMed Web of Science ®Google Scholar
• Popovic, M., M. Stojanovic, Z. Velickovic, A. Kovacevic, R. Miljkovic, N. Mirkovic, and A. Marinkovic. 2021. Characterization of potential probiotic strain, l. Reuteri b2, and its microencapsulation using alginate-based biopolymers. Int J Biol Macromol 183:423–434. doi: 10.1016/j.ijbiomac.2021.04.177.
   PubMed Web of Science ®Google Scholar
• Qi, X., S. Simsek, B. Chen, and J. Rao. 2020. Alginate-based double-network hydrogel improves the viability of encapsulated probiotics during simulated sequential gastrointestinal digestion: Effect of biopolymer type and concentrations. International Journal of Biological Macromolecules 165 (Pt B):1675–85. doi: 10.1016/j.ijbiomac.2020.10.028.
   PubMedGoogle Scholar
• Qin, X. S., Q. Y. Gao, and Z. G. Luo. 2021. Enhancing the storage and gastrointestinal passage viability of probiotic powder (Lactobacillus Plantarum) through encapsulation with pickering high internal phase emulsions stabilized with WPI-EGCG covalent conjugate nanoparticles. Food Hydrocolloids 116:106658. doi: 10.1016/j.foodhyd.2021.106658.
   Web of Science ®Google Scholar
• Qin, X. S., Z. G. Luo, and X. L. Li. 2021. An enhanced pH-sensitive carrier based on alginate-Ca-EDTA in a set-type W1/O/W2 double emulsion model stabilized with WPI-EGCG covalent conjugates for probiotics colon-targeted release. Food Hydrocolloids 113:106460. doi: 10.1016/j.foodhyd.2020.106460.
   Web of Science ®Google Scholar
• Qiu, K., Y. Huang, and A. C. Anselmo. 2021. Polymer and crosslinker content influences performance of encapsulated live biotherapeutic products. Cellular and Molecular Bioengineering 14 (5):487–99. doi: 10.1007/s12195-021-00674-z.
   PubMed Web of Science ®Google Scholar
• Quintana, G., E. Gerbino, P. Alves, P. N. Simoes, M. L. Rua, C. Fucinos, and A. Gomez-Zavaglia. 2021. Microencapsulation of Lactobacillus plantarum in W/O emulsions of okara oil and block-copolymers of poly(acrylic acid) and pluronic using microfluidic devices. Food Research International 140:110053. doi: 10.1016/j.foodres.2020.110053.
   PubMed Web of Science ®Google Scholar
• Raddatz, G. C., G. Poletto, C. de Deus, C. F. Codevilla, A. J. Cichoski, E. Jacob-Lopes, E. I. Muller, E. M. M. Flores, E. A. Esmerino, and C. R. de Menezes. 2020. Use of prebiotic sources to increase probiotic viability in pectin microparticles obtained by emulsification/internal gelation followed by freeze-drying. Food Research International (Ottawa, ON) 130:108902. doi: 10.1016/j.foodres.2019.108902.
   PubMed Web of Science ®Google Scholar
• Rashidinejad, A., A. Bahrami, A. Rehman, A. Rezaei, A. Babazadeh, H. Singh, and S. M. Jafari. 2020. Co-encapsulation of probiotics with prebiotics and their application in functional/synbiotic dairy products. Critical Reviews in Food Science and Nutrition Advance online publication. doi: 10.1080/10408398.2020.1854169. PMID: 33251846
   Web of Science ®Google Scholar
• Rasika, D. M. D., J. K. Vidanarachchi, R. S. Rocha, C. F. Balthazar, A. G. Cruz, A. S. Sant’Ana, and C. S. Ranadheera. 2021. Plant-based milk substitutes as emerging probiotic carriers. Current Opinion in Food Science 38:8–20. doi: 10.1016/j.cofs.2020.10.025.
   Web of Science ®Google Scholar
• Razavi, S., S. Janfaza, N. Tasnim, D. L. Gibson, and M. Hoorfar. 2021. Microencapsulating polymers for probiotics delivery systems: Preparation, characterization, and applications. Food Hydrocolloids 120:106882. doi: 10.1016/j.foodhyd.2021.106882.
   Web of Science ®Google Scholar
• Rolim, F. R. L., O. C. F. Neto, M. E. G. Oliveira, C. J. B. Oliveira, and R. C. R. E. Queiroga. 2020. Cheeses as food matrixes for probiotics: In vitro and in vivo tests. Trends in Food Science & Technology 100:138–54. doi: 10.1016/j.tifs.2020.04.008.
   Web of Science ®Google Scholar
• Shakeel, A., F. R. Lupi, D. Gabriele, N. Baldino, and B. De Cindio. 2018. Bigels: A unique class of materials for drug delivery applications. Soft Materials 16 (2):77–93. doi: 10.1080/1539445X.2018.1424638.
   Web of Science ®Google Scholar
• Sharifi, S., M. Rezazad-Bari, M. Alizadeh, H. Almasi, and S. Amiri. 2021. Use of whey protein isolate and gum Arabic for the co-encapsulation of probiotic Lactobacillus plantarum and phytosterols by complex coacervation: Enhanced viability of probiotic in Iranian white cheese. Food Hydrocolloids 113:106496. doi: 10.1016/j.foodhyd.2020.106496.
   Web of Science ®Google Scholar
• Sharma, M., A. Wasan, and R. K. Sharma. 2021. Recent developments in probiotics: An emphasis on Bifidobacterium. Food Bioscience 41:100993. doi: 10.1016/j.fbio.2021.100993.
   Web of Science ®Google Scholar
• Silva, M. P., F. L. Tulini, F. E. Matos, Jr, M. G. Oliveira, M. Thomazini, and C. S. Fávaro-Trindade. 2018. Application of spray chilling and electrostatic interaction to produce lipid microparticles loaded with probiotics as an alternative to improve resistance under stress conditions. Food Hydrocolloids 83:109–17. doi: 10.1016/j.foodhyd.2018.05.001.
   Web of Science ®Google Scholar
• Singh, P., B. Medronho, M. G. Miguel, and J. Esquena. 2018. On the encapsulation and viability of probiotic bacteria in edible carboxymethyl cellulose-gelatin water-in-water emulsions. Food Hydrocolloids 75:41–50. doi: 10.1016/j.foodhyd.2017.09.014.
   Web of Science ®Google Scholar
• Stamatopoulos, K., V. Kafourou, H. K. Batchelor, and S. J. Konteles. 2021. Sporopollenin exine microcapsules as potential intestinal delivery system of probiotics. Small (Weinheim an Der Bergstrasse, Germany) 17 (7):e2004573. doi: 10.1002/smll.202004573.
   PubMed Web of Science ®Google Scholar
• Su, J. Q., Y. J. Cai, K. D. Tai, Q. Guo, S. X. Zhu, L. K. Mao, Y. X. Gao, F. Yuan, and P. Van der Meeren. 2021. High-internal-phase emulsions (HIPEs) for co-encapsulation of probiotics and curcumin: Enhanced survivability and controlled release. Food & Function 12 (1):70–82. doi: 10.1039/d0fo01659d.
   PubMed Web of Science ®Google Scholar
• Su, J. Q., Y. J. Cai, Z. J. Zhi, Q. Guo, L. K. Mao, Y. X. Gao, F. Yuan, and P. Van der Meeren. 2021. Assembly of propylene glycol alginate/β-lactoglobulin composite hydrogels induced by ethanol for co-delivery of probiotics and curcumin. Carbohydrate Polymers 254:117446. doi: 10.1016/j.carbpol.2020.117446.
   PubMed Web of Science ®Google Scholar
• Synytska, A., and L. Ionov. 2013. Stimuli-responsive janus particles. Particle & Particle Systems Characterization 30 (11):922–30. doi: 10.1002/ppsc.201300146.
   Web of Science ®Google Scholar
• Tan, L. L., K. Sampathkumar, J. H. Wong, and S. C. J. Loo. 2020. Divalent cations are antagonistic to survivability of freeze-dried probiotics encapsulated in cross-linked alginate. Food and Bioproducts Processing 124:369–77. doi: 10.1016/j.fbp.2020.09.013.
   Web of Science ®Google Scholar
• Vaishanavi, S., and R. Preetha. 2021. Soy protein incorporated nanoemulsion for enhanced stability of probiotic (Lactobacillus delbrueckii subsp. bulgaricus) and its characterization. Materials Today: Proceedings 40:S148–S153. doi: 10.1016/j.matpr.2020.05.008.
   Google Scholar
• Wang, L., M. Y. Song, Z. J. Zhao, X. Chen, J. Y. Cai, Y. Cao, and J. Xiao. 2020. Lactobacillus acidophilus loaded pickering double emulsion with enhanced viability and colon-adhesion efficiency. Lebensmittel-Wissenschaft und -Technologie- Food Science and Technology 121:108928. doi: 10.1016/j.lwt.2019.108928.
   Web of Science ®Google Scholar
• Wang, M., Y. Li, J. Yang, R. Shi, L. Xiong, and Q. Sun. 2021. Effects of food-grade inorganic nanoparticles on the probiotic properties of Lactobacillus plantarum and Lactobacillus fermentum. Lebensmittel-Wissenschaft und -Technologie- Food Science and Technology 139:110540. doi: 10.1016/j.lwt.2020.110540.
   Web of Science ®Google Scholar
• Wei, Z., and Q. Huang. 2019. Assembly of protein-polysaccharide complexes for delivery of bioactive ingredients: A perspective paper. Journal of Agricultural and Food Chemistry 67 (5):1344–52. doi: 10.1021/acs.jafc.8b06063.
   PubMed Web of Science ®Google Scholar
• Xia, T., C. Xue, and Z. Wei. 2021. Physicochemical characteristics, applications and research trends of edible Pickering emulsions. Trends in Food Science & Technology 107:1–15. doi: 10.1016/j.tifs.2020.11.019.
   Web of Science ®Google Scholar
• Xiao, Y., C. B. Lu, Y. Y. Liu, L. L. Kong, H. Bai, H. B. Mu, Z. H. Li, H. L. Geng, and J. Y. Duan. 2020. Encapsulation of Lactobacillus rhamnosus in hyaluronic acid-based hydrogel for pathogen-targeted delivery to ameliorate enteritis. ACS Applied Materials & Interfaces 12 (33):36967–77. doi: 10.1021/acsami.0c11959.
   PubMed Web of Science ®Google Scholar
• Xie, J. J., M. F. Yao, Y. M. Lu, M. J. Yu, S. Y. Han, D. J. McClements, H. Xiao, and L. J. Li. 2021. Impact of encapsulating a probiotic (Pediococcus pentosaceus Li05) within gastro-responsive microgels on Clostridium difficile infections. Food & Function 12 (7):3180–90. doi: 10.1039/d0fo03235b.
   PubMed Web of Science ®Google Scholar
• Yan, W., X. Jia, Q. Zhang, H. Chen, Q. Zhu, and L. Yin. 2021. Interpenetrating polymer network hydrogels of soy protein isolate and sugar beet pectin as a potential carrier for probiotics. Food Hydrocolloids 113:106453. doi: 10.1016/j.foodhyd.2020.106453.
   Web of Science ®Google Scholar
• Yang, L., Z. Han, C. H. Chen, Z. Y. Li, S. P. Yu, Y. Qu, and R. Zeng. 2020. Novel probiotic-bound oxidized Bletilla striata polysaccharide-chitosan composite hydrogel. Materials Science & Engineering. C, Materials for Biological Applications 117:111265. doi: 10.1016/j.msec.2020.111265.
   PubMed Web of Science ®Google Scholar
• Yilmaz, M. T., O. Taylan, C. Y. Karakas, and E. Dertli. 2020. An alternative way to encapsulate probiotics within electrospun alginate nanofibers as monitored under simulated gastrointestinal conditions and in kefir. Carbohydrate Polymers 244:116447. doi: 10.1016/j.carbpol.2020.116447.
   PubMed Web of Science ®Google Scholar
• Yu, H., W. Liu, D. Li, C. Liu, Z. Feng, and B. Jiang. 2020. Targeting delivery system for Lactobacillus Plantarum based on functionalized electrospun nanofibers. Polymers 12 (7):1565. doi: 10.3390/polym12071565.
   PubMed Web of Science ®Google Scholar
• Yuan, L., H. Wei, X. Y. Yang, W. Geng, B. W. Peterson, H. C. van der Mei, and H. J. Busscher. 2021. Escherichia coli colonization of intestinal epithelial layers in vitro in the presence of encapsulated Bifidobacterium breve for its protection against gastrointestinal fluids and antibiotics. ACS Applied Materials & Interfaces 13 (14):15973–82. doi: 10.1021/acsami.0c21790.
   PubMed Web of Science ®Google Scholar
• Zaeim, D., M. Sarabi-Jamab, B. Ghorani, R. Kadkhodaee, W. Liu, and R. H. Tromp. 2020. Microencapsulation of probiotics in multi-polysaccharide microcapsules by electro-hydrodynamic atomization and incorporation into ice-cream formulation. Food Structure 25:100147. doi: 10.1016/j.foostr.2020.100147.
   Web of Science ®Google Scholar
• Zhang, H. C., S. Y. Wei, J. Yan, M. M. Feng, Y. F. Bai, B. Chen, and J. X. Xu. 2021. Development of double layer microcapsules for enhancing the viability of Lactobacillus casei LC2W in simulated gastrointestinal fluids. Lebensmittel-Wissenschaft und -Technologie- Food Science and Technology 145:111319. doi: 10.1016/j.lwt.2021.111319.
   Web of Science ®Google Scholar
• Zhang, Z. H., M. F. Li, F. Peng, S. R. Zhong, Z. Huang, M. H. Zong, and W. Y. Lou. 2021. Oxidized high-amylose starch macrogel as a novel delivery vehicle for probiotic and bioactive substances. Food Hydrocolloids 114:106578. doi: 10.1016/j.foodhyd.2020.106578.
   Web of Science ®Google Scholar
• Zhang, Z., M. Gu, X. You, D. A. Sela, H. Xiao, and D. J. McClements. 2021. Encapsulation of bifidobacterium in alginate microgels improves viability and targeted gut release. Food Hydrocolloids 116:106634. doi: 10.1016/j.foodhyd.2021.106634.
   Web of Science ®Google Scholar
• Zhao, C., Y. Zhu, B. Kong, Y. Huang, D. Yan, H. Tan, and L. Shang. 2020. Dual-core prebiotic microcapsule encapsulating probiotics for metabolic syndrome. ACS Applied Materials & Interfaces 12 (38):42586–94. doi: 10.1021/acsami.0c13518.
   PubMed Web of Science ®Google Scholar
• Zhao, M., X. Huang, H. Zhang, Y. Z. Zhang, M. Ganzle, N. Yang, K. Nishinari, and Y. P. Fang. 2020. Probiotic encapsulation in water-in-water emulsion via heteroprotein complex coacervation of type-A gelatin/sodium caseinate. Food Hydrocolloids 105:105790. doi: 10.1016/j.foodhyd.2020.105790.
   Web of Science ®Google Scholar
• Zhao, W., Z. Wei, and C. Xue. 2021. Recent advances on food-grade oleogels: Fabrication, application and research trends. Critical Reviews in Food Science and Nutrition. Advance online publication. doi: 10.1080/10408398.2021.1922354.
   Web of Science ®Google Scholar
• Zhuang, X., N. Gaudino, S. Clark, and N. C. Acevedo. 2021. Novel lecithin-based oleogels and oleogel emulsions delay lipid oxidation and extend probiotic bacteria survival. Lebensmittel-Wissenschaft und -Technologie- Food Science and Technology 136:110353. doi: 10.1016/j.lwt.2020.110353.
   Web of Science ®Google Scholar
• Zhuge, A. X., B. Li, Y. Yuan, L. X. Lv, Y. T. Li, J. J. Wu, L. Y. Yang, X. Y. Bian, K. C. Wang, Q. Q. Wang, et al. 2020. Lactobacillus salivarius LI01 encapsulated in alginate-pectin microgels ameliorates D-galactosamine-induced acute liver injury in rats. Applied Microbiology and Biotechnology 104 (17):7437–55. doi: 10.1007/s00253-020-10749-y.
   PubMed Web of Science ®Google Scholar