Vitamin D, testosterone and depression in middle-aged and elderly men: a systematic review

References

• Alderson, L. M., and M. J. Baum. 1981. Differential effects of gonadal steroids on dopamine metabolism in mesolimbic and nigro-striatal pathways of male rat brain. Brain Research 218 (1-2):189–206. doi: 10.1016/0006-8993(81)91300-7.
   PubMed Web of Science ®Google Scholar
• Almeida, O. P., G. J. Hankey, B. B. Yeap, J. Golledge, and L. Flicker. 2015. Vitamin D concentration and its association with past, current and future depression in older men: The Health In Men Study. Maturitas 81 (1):36–41. doi: 10.1016/j.maturitas.2015.01.016.
   PubMed Web of Science ®Google Scholar
• Anic, G. M., D. Albanes, S. Rohrmann, N. Kanarek, W. G. Nelson, G. Bradwin, N. Rifai, K. A. McGlynn, E. A. Platz, and A. M. Mondul. 2016. Association between serum 25-hydroxyvitamin D and serum sex steroid hormones among men in NHANES. Clinical Endocrinology 85 (2):258–66. doi: 10.1111/cen.13062.
   PubMed Web of Science ®Google Scholar
• Borges, M. C., L. A. Martini, and M. M. Rogero. 2011. Current perspectives on vitamin D, immune system, and chronic diseases. Nutrition 27 (4):399–404. doi: 10.1016/j.nut.2010.07.022.
   PubMed Web of Science ®Google Scholar
• Canguven, O., R. A. Talib, W. E. Ansari, D.-J. Yassin, and A. A. Naimi. 2017. Vitamin D treatment improves levels of sexual hormones, metabolic parameters and erectile function in middle-aged vitamin D deficient men. The Aging Male 20 (1):9–16. doi: 10.1080/13685538.2016.1271783.
   PubMed Web of Science ®Google Scholar
• Chan, R., D. Chan, J. Woo, C. Ohlsson, D. Mellström, T. Kwok, and P. Leung. 2011. Association between serum 25-hydroxyvitamin D and psychological health in older Chinese men in a cohort study. Journal of Affective Disorders 130 (1-2):251–9. doi: 10.1016/j.jad.2010.10.029.
   PubMed Web of Science ®Google Scholar
• Casey, D. A. 2017. Depression in older adults: A treatable medical condition. Primary Care 44 (3):499–510. doi: 10.1016/j.pop.2017.04.007.
   PubMed Web of Science ®Google Scholar
• Carnahan, R. M., and P. J. Perry. 2004. Depression in aging men: The role of testosterone. Drugs & Aging 21 (6):361–76. doi: 10.2165/00002512-200421060-00002.
   PubMed Web of Science ®Google Scholar
• Cashman, K. D. 2020. Vitamin D deficiency: Defining, prevalence, causes, and strategies of addressing. Calcified Tissue International 106 (1):14–29. doi: 10.1007/s00223-019-00559-4.
   PubMed Web of Science ®Google Scholar
• Chin, K.-Y., S. Ima-Nirwana, and W. Z. Wan Ngah. 2015. Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men. The Aging Male 18 (3):175–9. doi: 10.3109/13685538.2015.1034686.
   PubMed Web of Science ®Google Scholar
• de Oliveira, C., V. Hirani, and J. P. Biddulph. 2018. Associations between vitamin D levels and depressive symptoms in later life: Evidence from the English Longitudinal Study of Ageing (ELSA). The Journals of Gerontology: Series A 73 (10):1377–82. doi: 10.1093/gerona/glx130.
   PubMed Web of Science ®Google Scholar
• de Souza Silva, M., C. Mattern, B. Topic, T. Buddenberg, and J. Huston. 2009. Dopaminergic and serotonergic activity in neostriatum and nucleus accumbens enhanced by intranasal administration of testosterone. European Neuropsychopharmacology 19 (1):53–63. doi: 10.1016/j.euroneuro.2008.08.003.
   PubMed Web of Science ®Google Scholar
• Ellsworth-Bowers, E., and E. Corwin. 2012. Nutrition and the psychoneuroimmunology of postpartum depression. Nutrition Research Reviews 25 (1):180–92. doi: 10.1017/S0954422412000091.
   PubMed Web of Science ®Google Scholar
• Elstgeest, L. E., E. J. De Koning, I. A. Brouwer, N. M. Van Schoor, B. W. Penninx, and M. Visser. 2018. Change in serum 25-hydroxyvitamin D and parallel change in depressive symptoms in Dutch older adults. European Journal of Endocrinology 179 (4):239–49. doi: 10.1530/EJE-18-0187.
   PubMed Web of Science ®Google Scholar
• Eyles, D. W., T. H. Burne, and J. J. McGrath. 2013. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Frontiers in Neuroendocrinology 34 (1):47–64. doi: 10.1016/j.yfrne.2012.07.001.
   PubMed Web of Science ®Google Scholar
• Eyles, D. W., S. Smith, R. Kinobe, M. Hewison, and J. J. McGrath. 2005. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain . Journal of Chemical Neuroanatomy 29 (1):21–30. doi: 10.1016/j.jchemneu.2004.08.006.
   PubMed Web of Science ®Google Scholar
• Foresta, C., G. Strapazzon, L. De Toni, L. Perilli, A. D. Mambro, B. Muciaccia, L. Sartori, and R. Selice. 2011. Bone mineral density and testicular failure: Evidence for a role of vitamin D 25-hydroxylase in human testis. The Journal of Clinical Endocrinology & Metabolism 96 (4):E646–E652. doi: 10.1210/jc.2010-1628.
   PubMed Web of Science ®Google Scholar
• Fui, M. N., P. Dupuis, and M. Grossmann. 2014. Lowered testosterone in male obesity: Mechanisms, morbidity and management. Asian Journal of Andrology 16 (2):223–31. doi: 10.4103/1008-682X.122365.
   PubMed Web of Science ®Google Scholar
• Gáll, Z., and O. Székely. 2021. Role of vitamin D in cognitive dysfunction: New molecular concepts and discrepancies between animal and human findings. Nutrients 13 (11):3672. doi: 10.3390/nu13113672.
   PubMed Web of Science ®Google Scholar
• Grossmann, M. 2019. Androgen deficiency in older men. Australian Journal of General Practice 48 (7):446–50. doi: 10.31128/AJGP-01-19-4831.
   PubMed Web of Science ®Google Scholar
• Hakimi, S., L. Ghasemi, M. Mirghafourvand, K. Hassanzadeh, and F. Ghasemi. 2019. The prevalence of andropause symptoms and the role of social determinants of health on its severity in healthy men: A community-based study in Northwest Iran. Crescent Journal of Medical and Biological Sciences 6 (3):341–5.
   Web of Science ®Google Scholar
• Harman, S. M., E. J. Metter, J. D. Tobin, J. Pearson, and M. R. Blackman. 2001. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. The Journal of Clinical Endocrinology and Metabolism 86 (2):724–31. doi: 10.1210/jcem.86.2.7219.
   PubMed Web of Science ®Google Scholar
• Heijboer, A. C., M. Oosterwerff, N. F. Schroten, E. M. Eekhoff, V. G. Chel, R. A. de Boer, M. A. Blankenstein, and P. Lips. 2015. Vitamin D supplementation and testosterone concentrations in male human subjects. Clinical Endocrinology 83 (1):105–10. doi: 10.1111/cen.12711.
   PubMed Web of Science ®Google Scholar
• Hofer, D., J. Münzker, V. Schwetz, M. Ulbing, K. Hutz, P. Stiegler, R. Zigeuner, T. Pieber, H. Müller, and B. Obermayer-Pietsch. 2014. Testicular synthesis and vitamin D action. The Journal of Clinical Endocrinology and Metabolism 99 (10):3766–73. doi: 10.1210/jc.2014-1690.
   PubMed Web of Science ®Google Scholar
• Hosseini Marnani, E., M. Mollahosseini, A. Gheflati, A. Ghadiri‐Anari, and A. Nadjarzadeh. 2019. The effect of vitamin D supplementation on the androgenic profile in men: A systematic review and meta-analysis of clinical trials. Andrologia 51 (9):e13343. doi: 10.1111/and.13343.
   PubMed Web of Science ®Google Scholar
• IOM (Institute of Medicine). 2011. Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press. doi: 10.17226/13050.
   Google Scholar
• Jääskeläinen, T., P. Knekt, J. Suvisaari, S. Männistö, T. Partonen, K. Sääksjärvi, N. E. Kaartinen, N. Kanerva, and O. Lindfors. 2015. Higher serum 25-hydroxyvitamin D concentrations are related to a reduced risk of depression. The British Journal of Nutrition 113 (9):1418–26. doi: 10.1017/S0007114515000689.
   PubMed Web of Science ®Google Scholar
• Jensen, M. B., J. Gerner Lawaetz, A.-M. Andersson, J. H. Petersen, L. Nordkap, A. K. Bang, P. Ekbom, U. N. Joensen, L. Praetorius, P. Lundstrøm, et al. 2016. Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men. Human Reproduction 31 (8):1875–85. doi: 10.1093/humrep/dew152.
   PubMed Web of Science ®Google Scholar
• Kwong, J. C., Y. Krakowsky, and E. Grober. 2019. Testosterone deficiency: A review and comparison of current guidelines. The Journal of Sexual Medicine 16 (6):812–20. doi: 10.1016/j.jsxm.2019.03.262.
   PubMed Web of Science ®Google Scholar
• Lee, D. M., A. Tajar, T. W. O’Neill, D. B. O’Connor, G. Bartfai, S. Boonen, R. Bouillon, F. F. Casanueva, J. D. Finn, G. Forti, et al. 2011. Lower vitamin D levels are associated with depression among community-dwelling European men. Journal of Psychopharmacology 25 (10):1320–8. doi: 10.1177/0269881110379287.
   PubMed Web of Science ®Google Scholar
• Lee, D. M., A. Tajar, S. R. Pye, S. Boonen, D. Vanderschueren, R. Bouillon, T. W. O’Neill, G. Bartfai, F. F. Casanueva, J. D. Finn, et al. 2012. Association of hypogonadism with vitamin D status: The European Male Ageing Study. European Journal of Endocrinology 166 (1):77–85. doi: 10.1530/EJE-11-0743.
   PubMed Web of Science ®Google Scholar
• Lerchbaum, E., S. Pilz, C. Trummer, T. Rabe, M. Schenk, A. Heijboer, and B. Obermayer‐Pietsch. 2014. Serum vitamin D levels and hypogonadism in men. Andrology 2 (5):748–54. doi: 10.1111/j.2047-2927.2014.00247.x.
   PubMed Web of Science ®Google Scholar
• Lerchbaum, E., S. Pilz, C. Trummer, V. Schwetz, O. Pachernegg, A. C. Heijboer, and B. Obermayer-Pietsch. 2017. Vitamin D and testosterone in healthy men: A randomized controlled trial. The Journal of Clinical Endocrinology & Metabolism 102 (11):4292–302. doi: 10.1210/jc.2017-01428.
   PubMed Web of Science ®Google Scholar
• Lerchbaum, E., C. Trummer, V. Theiler-Schwetz, M. Kollmann, M. Wölfler, A. C. Heijboer, S. Pilz, and B. Obermayer-Pietsch. 2019. Effects of vitamin D supplementation on androgens in men with low testosterone levels: A randomized controlled trial. European Journal of Nutrition 58 (8):3135–46. doi: 10.1007/s00394-018-1858-z.
   PubMed Web of Science ®Google Scholar
• Low, W. Y., S. F. Tong, and H. M. Tan. 2008. Erectile dysfunction, premature ejaculation and hypogonadism and men’s quality of life: An Asian perspective. Journal of Men’s Health 5 (4):282–8. doi: 10.1016/j.jomh.2008.10.004.
   Web of Science ®Google Scholar
• Matthews, J., S. J. Torres, C. M. Milte, I. Hopkins, S. Kukuljan, C. A. Nowson, and R. M. Daly. 2020. Effects of a multicomponent exercise program combined with calcium-vitamin D3-enriched milk on health-related quality of life and depressive symptoms in older men: Secondary analysis of a randomized controlled trial. European Journal of Nutrition 59 (3):1081–91. doi: 10.1007/s00394-019-01969-8.
   PubMed Web of Science ®Google Scholar
• McGill, J. J., D. A. Shoskes, and E. S. Sabanegh. 2012. Androgen deficiency in older men: Indications, advantages, and pitfalls of testosterone replacement therapy. Cleveland Clinic Journal of Medicine 79 (11):797–806. doi: 10.3949/ccjm.79a.12010.
   PubMed Web of Science ®Google Scholar
• McGrath, J. J., D. W. Eyles, C. B. Pedersen, C. Anderson, P. Ko, T. H. Burne, B. Norgaard-Pedersen, D. M. Hougaard, and P. B. Mortensen. 2010. Neonatal vitamin D status and risk of schizophrenia: A population-based case-control study. Archives of General Psychiatry 67 (9):889–94. doi: 10.1001/archgenpsychiatry.2010.110.
   PubMed Web of Science ®Google Scholar
• McHenry, J., N. Carrier, E. Hull, and M. Kabbaj. 2014. Sex differences in anxiety and depression: Role of testosterone. Frontiers in Neuroendocrinology 35 (1):42–57. doi: 10.1016/j.yfrne.2013.09.001.
   PubMed Web of Science ®Google Scholar
• Newmark, H. L., and J. Newmark. 2007. Vitamin D and Parkinson’s disease-a hypothesis. Movement Disorders 22 (4):461–8. doi: 10.1002/mds.21317.
   PubMed Web of Science ®Google Scholar
• Nimptsch, K., E. A. Platz, W. C. Willett, and E. Giovannucci. 2012. Association between plasma 25-OH vitamin D and testosterone levels in men. Clinical Endocrinology 77 (1):106–12. doi: 10.1111/j.1365-2265.2012.04332.x.
   PubMed Web of Science ®Google Scholar
• Okereke, O. I., C. F. Reynolds, D. Mischoulon, G. Chang, C. M. Vyas, N. R. Cook, A. Weinberg, V. Bubes, T. Copeland, G. Friedenberg, et al. 2020. Effect of long-term vitamin D3 supplementation vs placebo on risk of depression or clinically relevant depressive symptoms and on change in mood scores: A randomized clinical trial. Jama 324 (5):471–80. doi: 10.1001/jama.2020.10224.
   PubMed Web of Science ®Google Scholar
• Page, M. J., J. E. McKenzie, P. M. Bossuyt, I. Boutron, T. C. Hoffmann, C. D. Mulrow, L. Shamseer, J. M. Tetzlaff, E. A. Akl, S. E. Brennan, et al. 2021. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ 372:n71. doi: 10.1136/bmj.n71.
   PubMed Web of Science ®Google Scholar
• Parker, G. B., H. Brotchie, and R. K. Graham. 2017. Vitamin D and depression. J Affect Disord 208:56–61. doi: 10.1016/j.jad.2016.08.082.
   PubMed Web of Science ®Google Scholar
• Pilz, S., S. Frisch, H. Koertke, J. Kuhn, J. Dreier, B. Obermayer-Pietsch, E. Wehr, and A. Zittermann. 2011. Effect of vitamin D supplementation on testosterone levels in men. Hormone and Metabolic Research 43 (03):223–5. doi: 10.1055/s-0030-1269854.
   PubMedGoogle Scholar
• Rafiq, R., N. M. van Schoor, E. Sohl, M. C. Zillikens, M. Oosterwerff, L. Schaap, P. Lips, and R. de Jongh. 2016. Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men. The Journal of Steroid Biochemistry and Molecular Biology 164:11–7. doi: 10.1016/j.jsbmb.2015.11.013.
   PubMed Web of Science ®Google Scholar
• Rhee, S. J., H. Lee, and Y. M. Ahn. 2020. Serum vitamin D concentrations are associated with depressive symptoms in men: The Sixth Korea National Health and Nutrition Examination Survey 2014. Frontiers in Psychiatry 11:756. doi: 10.3389/fpsyt.2020.00756.
   PubMed Web of Science ®Google Scholar
• Ribeiro, O., L. Teixeira, L. Araújo, C. Rodríguez-Blázquez, A. Calderón-Larrañaga, and M. J. Forjaz. 2020. Anxiety, depression and quality of life in older adults: Trajectories of influence across age. International Journal of Environmental Research and Public Health 17 (23):9039. doi: 10.3390/ijerph17239039.
   PubMed Web of Science ®Google Scholar
• Robichaud, M., and G. Debonnel. 2005. Oestrogen and testosterone modulate the firing activity of dorsal raphe nucleus serotonergic neurones in both male and female rats. Journal of Neuroendocrinology 17 (3):179–85. doi: 10.1111/j.1365-2826.2005.01292.x.
   PubMed Web of Science ®Google Scholar
• Roth, D. E., S. A. Abrams, J. Aloia, G. Bergeron, M. W. Bourassa, K. H. Brown, M. S. Calvo, K. D. Cashman, G. Combs, L. M. De‐Regil, et al. 2018. Global prevalence and disease burden of vitamin D deficiency: A roadmap for action in low-and middle-income countries. Annals of the New York Academy of Sciences 1430 (1):44–79. doi: 10.1111/nyas.13968.
   PubMed Web of Science ®Google Scholar
• Samizadeh, E., S. Khosravi, A. Samizadeh, and S. Dabiran. 2014. Andropause: Results of a comprehensive surveillance of prevalence and risk factors on 906 patients (ACoSPF-2010). International Journal of Advanced Biological and Biomedical Research 2 (2):535–44.
   Google Scholar
• Seidman, S. N. 2003. Testosterone deficiency and mood in aging men: Pathogenic and therapeutic interactions. The World Journal of Biological Psychiatry 4 (1):14–20. doi: 10.3109/15622970309167905.
   PubMed Web of Science ®Google Scholar
• Seidman, S. N., and M. Weiser. 2013. Testosterone and mood in aging men. The Psychiatric Clinics of North America 36 (1):177–82. doi: 10.1016/j.psc.2013.01.007.
   PubMed Web of Science ®Google Scholar
• Stang, A. 2010. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. European Journal of Epidemiology 25 (9):603–5. doi: 10.1007/s10654-010-9491-z.
   PubMed Web of Science ®Google Scholar
• Tak, Y. J., J. G. Lee, Y. J. Kim, N. C. Park, S. S. Kim, S. Lee, B. M. Cho, E. H. Kong, D. W. Jung, and Y. H. Yi. 2015. Serum 25-hydroxyvitamin D levels and testosterone deficiency in middle-aged Korean men: A cross-sectional study. Asian Journal of Andrology 17 (2):324. doi: 10.4103/1008-682X.142137.
   PubMed Web of Science ®Google Scholar
• Toffanello, E. D., G. Sergi, N. Veronese, E. Perissinotto, S. Zambon, A. Coin, L. Sartori, E. Musacchio, M.-C. Corti, G. Baggio, et al. 2014. Serum 25-hydroxyvitamin d and the onset of late-life depressive mood in older men and women: The Pro.V.A. study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 69 (12):1554–61. doi: 10.1093/gerona/glu081.
   PubMed Web of Science ®Google Scholar
• Vranić, L., I. Mikolašević, and S. Milić. 2019. Vitamin D deficiency: Consequence or cause of obesity? Medicina 55 (9):541. doi: 10.3390/medicina55090541.
   PubMedGoogle Scholar
• Walther, A., J. Breidenstein, and R. Miller. 2019. Association of testosterone treatment with alleviation of depressive symptoms in men: A systematic review and meta-analysis. JAMA Psychiatry 76 (1):31–40. doi: 10.1001/jamapsychiatry.2018.2734.
   PubMed Web of Science ®Google Scholar
• Wang, N., B. Han, Q. Li, Y. Chen, Y. Chen, F. Xia, D. Lin, M. D. Jensen, and Y. Lu. 2015. Vitamin D is associated with testosterone and hypogonadism in Chinese men: Results from a cross-sectional SPECT-China study. Reproductive Biology and Endocrinology 13 (1):1–7. doi: 10.1186/s12958-015-0068-2.
   PubMedGoogle Scholar
• Wehr, E., S. Pilz, B. O. Boehm, W. Maerz, and B. Obermayer-Pietsch. 2009. Association of vitamin D status with serum androgen levels in men. Clinical Endocrinology 73 (2):243–8. doi: 10.1111/j.1365-226503777.x.
   PubMed Web of Science ®Google Scholar
• Zitzmann, M. 2006. Testosterone and the brain. The Aging Male 9 (4):195–9. doi: 10.1080/13685530601040679.
   PubMed Web of Science ®Google Scholar
• Zitzmann, M. 2020. Testosterone, mood, behaviour and quality of life. Andrology 8 (6):1598–605. doi: 10.1111/andr.12867.
   PubMed Web of Science ®Google Scholar