Efficacy of probiotics against dental caries in children: a systematic review and meta-analysis

References

• Acharya, A., S. Khan, H. Hoang, S. Bettiol, L. Goldberg, and L. Crocombe. 2018. Dental conditions associated with preventable hospital admissions in Australia: A systematic literature review. BMC Health Services Research 18 (1):921. doi: 10.1186/s12913-018-3733-2.
   PubMedGoogle Scholar
• Alamoudi, N. M., E. S. Almabadi, E. A. El Ashiry, and D. A. El Derwi. 2018. Effect of Probiotic Lactobacillus reuteri on salivary cariogenic bacterial counts among groups of preschool children in Jeddah, Saudi Arabia: A randomized clinical trial. The Journal of Clinical Pediatric Dentistry 42 (5):331–338. doi: 10.17796/1053-4625-42.5.2.
   PubMed Web of Science ®Google Scholar
• Alanzi, A., S. Honkala, E. Honkala, A. Varghese, M. Tolvanen, and E. Söderling. 2018. Effect of Lactobacillus rhamnosus and Bifidobacterium lactis on gingival health, dental plaque, and periodontopathogens in adolescents: A randomised placebo-controlled clinical trial. Beneficial Microbes 9 (4):593–602. doi: 10.3920/BM2017.0139.
   PubMed Web of Science ®Google Scholar
• Angarita-Díaz, M. P., D. Forero-Escobar, X. A. Cerón-Bastidas, C. A. Cisneros-Hidalgo, F. Dávila-Narvaez, C. M. Bedoya-Correa, S. C. Freitas, C. L. Cabrera-Arango, and R. Melo-Colina. 2020. Effects of a functional food supplemented with probiotics on biological factors related to dental caries in children: A pilot study. European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry 21 (1):161–9. doi: 10.1007/s40368-019-00468-y.
   PubMed Web of Science ®Google Scholar
• Ashwin, D., V. Ke, M. Taranath, N. K. Ramagoni, A. Nara, and M. Sarpangala. 2015. Effect of probiotic containing ice-cream on salivary mutans Streptococci (SMS) levels in children of 6-12 years of age: A randomized controlled double blind study with six-months follow up. Journal of Clinical and Diagnostic Research 9 (2): ZC06-9. doi: 10.7860/JCDR/2015/10942.5532.
   PubMedGoogle Scholar
• Bartold, P. M., and T. E. Van Dyke. 2013. Periodontitis: A host-mediated disruption of microbial homeostasis. Unlearning learned concepts. Periodontology 2000 62 (1):203–17. doi: 10.1111/j.1600-0757.2012.00450.x.
   PubMed Web of Science ®Google Scholar
• Becker, D. E. 2013a. Antimicrobial drugs. Anesthesia Progress 60 (3):111–22; quiz 123. doi: 10.2344/0003-3006-60.3.111.
   PubMedGoogle Scholar
• Becker, D. E. 2013b. Drug allergies and implications for dental practice. Anesthesia Progress 60 (4):188–97. doi: 10.2344/0003-3006-60.4.188.
   PubMedGoogle Scholar
• Bhalla, M., N. A. Ingle, N. Kaur, and P. Yadav. 2015. Mutans streptococci estimation in saliva before and after consumption of probiotic curd among school children. Journal of International Society of Preventive & Community Dentistry 5 (1):31–4. doi: 10.4103/2231-0762.151970.
   PubMedGoogle Scholar
• Bik, E. M., C. D. Long, G. C. Armitage, P. Loomer, J. Emerson, E. F. Mongodin, K. E. Nelson, S. R. Gill, C. M. Fraser-Liggett, and D. A. Relman. 2010. Bacterial diversity in the oral cavity of 10 healthy individuals. The ISME Journal 4 (8):962–74. doi: 10.1038/ismej.2010.30.
   PubMed Web of Science ®Google Scholar
• Bonifait, L., F. Chandad, and D. Grenier. 2009. Probiotics for oral health: Myth or reality? Journal (Canadian Dental Association) 75 (8):585–90.
   PubMedGoogle Scholar
• Bowen, W. H. 2013. The Stephan Curve revisited. Odontology 101 (1):2–8. doi: 10.1007/s10266-012-0092-z.
   PubMed Web of Science ®Google Scholar
• Burton, J. P., B. K. Drummond, C. N. Chilcott, J. R. Tagg, W. M. Thomson, J. D. F. Hale, and P. A. Wescombe. 2013. Influence of the probiotic Streptococcus salivarius strain M18 on indices of dental health in children: A randomized double-blind, placebo-controlled trial. Journal of Medical Microbiology 62 (Pt 6):875–‐84. doi: 10.1099/jmm.0.056663-0.
   PubMedGoogle Scholar
• Cagetti, M. G., S. Mastroberardino, E. Milia, F. Cocco, P. Lingström, and G. Campus. 2013. The use of probiotic strains in caries prevention: A systematic review. Nutrients 5 (7):2530–50. doi: 10.3390/nu5072530.
   PubMed Web of Science ®Google Scholar
• Caglar, E., B. Kargul, and I. Tanboga. 2005. Bacteriotherapy and probiotics’ role on oral health. Oral Diseases 11 (3):131–7. doi: 10.1111/j.1601-0825.2005.01109.x.
   PubMed Web of Science ®Google Scholar
• Campus, G., F. Cocco, G. Carta, M. G. Cagetti, C. Simark-Mattson, L. Strohmenger, and P. Lingström. 2014. Effect of a daily dose of Lactobacillus brevis CD2 lozenges in high caries risk school children. Clinical Oral Investigations 18 (2):555–‐61. doi: 10.1007/s00784-013-0980-9.
   PubMed Web of Science ®Google Scholar
• Chakraborty, B., and R. A. Burne. 2017. Effects of arginine on Streptococcus mutans growth, virulence gene expression, and stress tolerance. Applied and Environmental Microbiology 83 (15). doi: 10.1128/AEM.00496-17.
   Web of Science ®Google Scholar
• Chen, L., T. Mao, M. Du, Y. Yang, Q. Xu, and M. Fan. 2014. Caries status and quantification of four bacteria in saliva of Chinese preschool children: A cross-sectional study. Journal of Dental Sciences 9 (3):283–8. doi: 10.1016/j.jds.2014.01.001.
   Web of Science ®Google Scholar
• Chinnappa, A., H. Konde, S. Konde, S. Raj, and J. P. Beena. 2013. Probiotics for future caries control: A short-term clinical study. Indian Journal of Dental Research 24 (5):547–9. doi: 10.4103/0970-9290.123363.
   PubMedGoogle Scholar
• Cortes-Dorantes, N., M. S. Ruiz-Rodriguez, L. Karakowsky-Kleiman, J. A. Garrocho-Rangel, L. O. Sanchez-Vargas, and J. Pozos-Guillen. 2015. Probiotics and their effect on oral bacteria count in children: A pilot study. European Journal of Paediatric Dentistry 16 (1):56–60.
   PubMed Web of Science ®Google Scholar
• Dang, M. H., J. E. Jung, D. W. Lee, K. Y. Song, and J. G. Jeon. 2016. Recovery of acid production in Streptococcus mutans biofilms after short-term fluoride treatment. Caries Research 50 (4):363–71. doi: 10.1159/000446408.
   PubMed Web of Science ®Google Scholar
• Di Pierro, F., A. Zanvit, P. Nobili, P. Risso, and C. Fornaini. 2015. Cariogram outcome after 90 days of oral treatment with Streptococcus salivarius M18 in children at high risk for dental caries: Results of a randomized, controlled study. Clinical, Cosmetic and Investigational Dentistry 7:107–13. doi: 10.2147/CCIDE.S93066.
   PubMedGoogle Scholar
• Farges, J. C., B. Alliot-Licht, E. Renard, M. Ducret, A. Gaudin, A. J. Smith, and P. R. Cooper. 2015. Dental pulp defence and repair mechanisms in dental caries. Mediators of Inflammation 2015:230251. doi: 10.1155/2015/230251.
   PubMed Web of Science ®Google Scholar
• Forssten, S. D., M. Björklund, and A. C. Ouwehand. 2010. Streptococcus mutans, caries and simulation models. Nutrients 2 (3):290–8. doi: 10.3390/nu2030290.
   PubMed Web of Science ®Google Scholar
• Godson, J., J. Csikar, and S. White. 2018. Oral health of children in England: A call to action! Archives of Disease in Childhood 103 (1):5–10. doi: 10.1136/archdischild-2017-312725.
   PubMed Web of Science ®Google Scholar
• Gruner, D., S. Paris, and F. Schwendicke. 2016. Probiotics for managing caries and periodontitis: Systematic review and meta-analysis. Journal of Dentistry 48:16–25. doi: 10.1016/j.jdent.2016.03.002.
   PubMed Web of Science ®Google Scholar
• Gurunathan, D., J. Moses, and S. K. Arunachalam. 2018. Knowledge, attitude, and practice of mothers regarding oral hygiene of primary school children in Chennai, Tamil Nadu, India. International Journal of Clinical Pediatric Dentistry 11 (4):338–43. doi: 10.5005/jp-journals-10005-1535.
   PubMedGoogle Scholar
• Hassan, H., P. Lingstrom, and A. Carlen. 2015. Plaque pH in caries-free and caries-active young individuals before and after frequent rinses with sucrose and urea solution. Caries Research 49 (1):18–25. doi: 10.1159/000360798.
   PubMed Web of Science ®Google Scholar
• Hasslof, P., and C. Stecksen-Blicks. 2020. Chapter 10: Probiotic bacteria and dental caries. Monographs in Oral Science 28:99–107. doi: 10.1159/000455377.
   PubMedGoogle Scholar
• Hasslöf, P., C. E. West, F. K. Videhult, C. Brandelius, and C. Stecksén-Blicks. 2013. Early intervention with probiotic Lactobacillus paracasei F19 has no long-term effect on caries experience. Caries Research 47 (6):559–565. doi: 10.1159/000350524.
   PubMed Web of Science ®Google Scholar
• Hedayati-Hajikand, T., U. Lundberg, C. Eldh, and S. Twetman. 2015. Effect of probiotic chewing tablets on early childhood caries-a randomized controlled trial. BMC Oral Health 15 (1):112. doi: 10.1186/s12903-015-0096-5.
   PubMedGoogle Scholar
• Hoceini, A., N. Klouche Khelil, I. Ben-Yelles, A. Mesli, S. Ziouani, L. Ghellai, N. Aissaoui, F. Nas, and M. Arab. 2016. Caries-related factors and bacterial composition of supragingival plaques in caries free and caries active Algerian adults. Asian Pacific Journal of Tropical Biomedicine 6 (8):720–6. doi: 10.1016/j.apjtb.2016.06.011.
   Web of Science ®Google Scholar
• Holbrook, W. P. 1993. Dental caries and cariogenic factors in pre-school urban Icelandic children. Caries Research 27 (5):431–7. doi: 10.1159/000261575.
   PubMed Web of Science ®Google Scholar
• Hu, J., W. Jiang, X. Lin, H. Zhu, N. Zhou, Y. Chen, W. Wu, D. Zhang, and H. Chen. 2018. Dental caries status and caries risk factors in students ages 12-14 years in Zhejiang. Medical Science Monitor 24:3670–8. doi: 10.12659/MSM.907325.
   PubMed Web of Science ®Google Scholar
• Iwasaki, K., K. Maeda, K. Hidaka, K. Nemoto, Y. Hirose, and S. Deguchi. 2016. Daily intake of heat-killed Lactobacillus plantarum L-137 decreases the probing depth in patients undergoing supportive periodontal therapy. Oral Health and Preventive Dentistry 14 (3):207–14. doi: 10.3290/j.ohpd.a36099.
   PubMed Web of Science ®Google Scholar
• Janczarek, M., T. Bachanek, E. Mazur, and R. Chałas. 2016. The role of probiotics in prevention of oral diseases. Postepy Higieny i Medycyny Doswiadczalnej (Online) 70 (0):850–7. doi: 10.5604/17322693.1214381.
   PubMedGoogle Scholar
• Jindal, G., R. K. Pandey, J. Agarwal, and M. Singh. 2011. A comparative evaluation of probiotics on salivary mutans streptococci counts in Indian children. European Archives of Paediatric Dentistry 12 (4):211–5. doi: 10.1007/BF03262809.
   PubMedGoogle Scholar
• Juneja, A., and A. Kakade. 2012. Evaluating the effect of probiotic containing milk on salivary mutans streptococci levels. Journal of Clinical Pediatric Dentistry 37 (1):9–‐14. doi: 10.17796/jcpd.37.1.tq91178m7w876644.
   PubMed Web of Science ®Google Scholar
• Kamalaksharappa, S. K., R. Rai, P. Babaji, and M. C. Pradeep. 2018. Efficacy of probiotic and green tea mouthrinse on salivary pH. Journal of Indian Society of Pedodontics and Preventive Dentistry 36 (3):279–82. doi: 10.4103/JISPPD.JISPPD_49_18.
   PubMedGoogle Scholar
• Kavitha, M., G. S. Prathima, G. Kayalvizhi, A. Sanguida, G. Ezhumalai, and V. Ramesh. 2019. Evaluation of Streptococcus mutans serotypes e, f, and k in saliva samples of 6-12-year-old school children before and after a short-term daily intake of the probiotic lozenge. Journal of the Indian Society of Pedodontics and Preventive Dentistry 37 (1):67–74. doi: 10.4103/JISPPD.JISPPD_227_18.
   PubMedGoogle Scholar
• Keller, M. K., I. Nøhr Larsen, I. Karlsson, and S. Twetman. 2014. Effect of tablets containing probiotic bacteria (Lactobacillus reuteri) on early caries lesions in adolescents: A pilot study. Beneficial Microbes 5 (4):403–407. doi: 10.3920/BM2013.0089.
   PubMed Web of Science ®Google Scholar
• Koll, P., R. Mandar, H. Marcotte, E. Leibur, M. Mikelsaar, and L. Hammarstrom. 2008. Characterization of oral lactobacilli as potential probiotics for oral health. Oral Microbiology and Immunology 23 (2):139–47. doi: 10.1111/j.1399-302X.2007.00402.x.
   PubMedGoogle Scholar
• Lai, S., P. Lingström, M. G. Cagetti, F. Cocco, G. Meloni, M. A. Arrica, and G. Campus. 2021. Effect of Lactobacillus brevis CD2 containing lozenges and plaque pH and cariogenic bacteria in diabetic children: A randomised clinical trial. Clinical Oral Investigations 25 (1):115–123. doi: 10.1007/s00784-020-03342-0.
   PubMed Web of Science ®Google Scholar
• Laleman, I., V. Detailleur, D. E. Slot, V. Slomka, M. Quirynen, and W. Teughels. 2014. Probiotics reduce mutans streptococci counts in humans: A systematic review and meta-analysis. Clinical Oral Investigations 18 (6):1539–52. doi: 10.1007/s00784-014-1228-z.
   PubMed Web of Science ®Google Scholar
• Laleman, I., and W. Teughels. 2015. Probiotics in the dental practice: A review. Quintessence International (Berlin, Germany: 1985) 46 (3):255–64. doi: 10.3290/j.qi.a33182.
   PubMed Web of Science ®Google Scholar
• Lapirattanakul, J., R. Nomura, R. Okawa, S. Morimoto, P. Tantivitayakul, T. Maudcheingka, K. Nakano, and M. Matsumoto-Nakano. 2020. Oral Lactobacilli related to caries status of children with primary dentition. Caries Research 54 (2):194–204. doi: 10.1159/000506468.
   PubMed Web of Science ®Google Scholar
• Leong, P. M., M. G. Gussy, S. Y. Barrow, A. de Silva-Sanigorski, and E. Waters. 2013. A systematic review of risk factors during first year of life for early childhood caries. International Journal of Paediatric Dentistry 23 (4):235–50. doi: 10.1111/j.1365-263X.2012.01260.x.
   PubMed Web of Science ®Google Scholar
• Lexner, M. O., S. Blomqvist, G. Dahlén, and S. Twetman. 2010. Microbiological profiles in saliva and supragingival plaque from caries-active adolescents before and after a short-term daily intake of milk supplemented with probiotic bacteria: A pilot study. Oral Health & Preventive Dentistry 8 (4):383–388.
   PubMed Web of Science ®Google Scholar
• Li, J., Z. Huang, L. Mei, G. Li, and H. Li. 2015. Anti-caries effect of arginine-containing formulations in vivo: A systematic review and meta-analysis. Caries Research 49 (6):606–17. doi: 10.1159/000435894.
   PubMed Web of Science ®Google Scholar
• Lin, T. H., C. H. Lin, and T. M. Pan. 2018. The implication of probiotics in the prevention of dental caries. Applied Microbiology and Biotechnology 102 (2):577–86. doi: 10.1007/s00253-017-8664-z.
   PubMed Web of Science ®Google Scholar
• Liu, Y. L., M. Nascimento, and R. A. Burne. 2012. Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries. International Journal of Oral Science 4 (3):135–40. doi: 10.1038/ijos.2012.54.
   PubMed Web of Science ®Google Scholar
• Manmontri, C., A. Nirunsittirat, S. Piwat, O. Wattanarat, N. Pahumunto, A. Makeudom, T. Sastraruji, S. Krisanaprakornkit, and R. Teanpaisan. 2020. Reduction of Streptococcus mutans by probiotic milk: A multicenter randomized controlled trial. Clinical Oral Investigations 24 (7):2363–74. doi: 10.1007/s00784-019-03095-5.
   PubMed Web of Science ®Google Scholar
• Maragkoudakis, P. A., G. Zoumpopoulou, C. Miaris, G. Kalantzopoulos, B. Pot, and E. Tsakalidou. 2006. Probiotic potential of Lactobacillus strains isolated from dairy products. International Dairy Journal 16 (3):189–99. doi: 10.1016/j.idairyj.2005.02.009.
   Web of Science ®Google Scholar
• Marsh, P. D. 2004. Dental plaque as a microbial biofilm. Caries Research 38 (3):204–11. doi: 10.1159/000077756.
   PubMed Web of Science ®Google Scholar
• Martins-Junior, P. A., R. G. Vieira-Andrade, P. Correa-Faria, F. Oliveira-Ferreira, L. S. Marques, and M. L. Ramos-Jorge. 2013. Impact of early childhood caries on the oral health-related quality of life of preschool children and their parents. Caries Research 47 (3):211–8. doi: 10.1159/000345534.
   PubMed Web of Science ®Google Scholar
• Meurman, J. H., H. Antila, A. Korhonen, and S. Salminen. 1995. Effect of Lactobacillus rhamnosus strain GG (ATCC 53103) on the growth of Streptococcus sobrinus in vitro. European Journal of Oral Sciences 103 (4):253–8. doi: 10.1111/j.1600-0722.1995.tb00169.x.
   PubMed Web of Science ®Google Scholar
• Meurman, J. H., and I. Stamatova. 2007. Probiotics: Contributions to oral health. Oral Diseases 13 (5):443–51. doi: 10.1111/j.1601-0825.2007.01386.x.
   PubMed Web of Science ®Google Scholar
• Moynihan, P. 2016. Sugars and dental caries: Evidence for setting a recommended threshold for intake. Advances in Nutrition 7 (1):149–56. doi: 10.3945/an.115.009365.
   PubMed Web of Science ®Google Scholar
• Nadelman, P., M. B. Magno, D. Masterson, A. G. da Cruz, and L. C. Maia. 2018. Are dairy products containing probiotics beneficial for oral health? A systematic review and meta-analysis. Clinical Oral Investigations 22 (8):2763–85. doi: 10.1007/s00784-018-2682-9.
   PubMed Web of Science ®Google Scholar
• Näse, L., K. Hatakka, E. Savilahti, M. Saxelin, A. Pönkä, T. Poussa, R. Korpela, and J. H. Meurman. 2001. Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries Research 35 (6):412–20. doi: 10.1159/000047484.
   PubMed Web of Science ®Google Scholar
• Ngamphaiboon, J., P. Chatchatee, and T. Thongkaew. 2008. Cow’s milk allergy in Thai children. Asian Pacific Journal of Allergy and Immunology 26 (4):199–204.
   PubMed Web of Science ®Google Scholar
• Nozari, A., M. Motamedifar, N. Seifi, Z. Hatamizargaran, and M. A. Ranjbar. 2015. The effect of iranian customary used probiotic yogurt on the children’s salivary cariogenic microflora. Journal of Dentistry (Shiraz, Iran) 16 (2):81–6.
   PubMedGoogle Scholar
• Page, M. J., J. E. McKenzie, P. M. Bossuyt, I. Boutron, T. C. Hoffmann, C. D. Mulrow, L. Shamseer, J. M. Tetzlaff, E. A. Akl, S. E. Brennan, et al. 2021. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. International Journal of Surgery (London, England) 88:105906. doi: 10.1016/j.ijsu.2021.105906.
   PubMed Web of Science ®Google Scholar
• Pahumunto, N., S. Piwat, O. Chankanka, N. Akkarachaneeyakorn, K. Rangsitsathian, and R. Teanpaisan. 2018. Reducing mutans streptococci and caries development by Lactobacillus paracasei SD1 in preschool children: A randomized placebo-controlled trial. Acta Odontologica Scandinavica 76 (5):331–7. doi: 10.1080/00016357.2018.1453083.
   PubMed Web of Science ®Google Scholar
• Pahumunto, N., S. Piwat, S. Chanvitan, W. Ongwande, S. Uraipan, and R. Teanpaisan. 2020. Fermented milk containing a potential probiotic Lactobacillus rhamnosus SD11 with maltitol reduces Streptococcus mutans: A double-blind, randomized, controlled study. Journal of Dental Sciences 15 (4):403–10. doi: 10.1016/j.jds.2020.03.003.
   PubMed Web of Science ®Google Scholar
• Pahumunto, N., B. Sophatha, S. Piwat, and R. Teanpaisan. 2019. Increasing salivary IgA and reducing Streptococcus mutans by probiotic Lactobacillus paracasei SD1: A double-blind, randomized, controlled study. Journal of Dental Sciences 14 (2):178–84. doi: 10.1016/j.jds.2019.01.008.
   PubMed Web of Science ®Google Scholar
• Patil, R. U., P. P. Dastoor, and M. P. Unde. 2019. Comparative evaluation of antimicrobial effectiveness of probiotic milk and fluoride mouthrinse on salivary Streptococcus mutans counts and plaque scores in children: An in vivo experimental study. Journal of the Indian Society of Pedodontics and Preventive Dentistry 37 (4):378–82. doi: 10.4103/JISPPD.JISPPD_45_19.
   PubMedGoogle Scholar
• Penala, S., B. Kalakonda, K. R. Pathakota, A. Jayakumar, P. Koppolu, B. V. Lakshmi, R. Pandey, and A. Mishra. 2016. Efficacy of local use of probiotics as an adjunct to scaling and root planning in chronic periodontitis and halitosis: A randomized controlled trial. Journal of Research in Pharmacy Practice 5 (2):86–93. doi: 10.4103/2279-042X.179568.
   PubMed Web of Science ®Google Scholar
• Petersen, P. E., D. Bourgeois, H. Ogawa, S. Estupinan-Day, and C. Ndiaye. 2005. The global burden of oral diseases and risks to oral health. Bulletin of the World Health Organization 83 (9):661–9.
   PubMed Web of Science ®Google Scholar
• Pham, L. C., M. A. Hoogenkamp, R. A. Exterkate, Z. Terefework, J. J. de Soet, J. M. ten Cate, W. Crielaard, and E. Zaura. 2011. Effects of Lactobacillus rhamnosus GG on saliva-derived microcosms. Archives of Oral Biology 56 (2):136–47. doi: 10.1016/j.archoralbio.2010.09.019.
   PubMed Web of Science ®Google Scholar
• Piwat, S., R. Teanpaisan, G. Dahlen, S. Thitasomakul, and C. W. Douglas. 2012. Acid production and growth by oral Lactobacillus species in vitro. Journal of Investigative and Clinical Dentistry 3 (1):56–61. doi: 10.1111/j.2041-1626.2011.00098.x.
   PubMedGoogle Scholar
• Piwat, S., R. Teanpaisan, C. Manmontri, O. Wattanarat, N. Pahumunto, A. Makeudom, S. Krisanaprakornkit, and A. Nirunsittirat. 2020. Efficacy of probiotic milk for caries regression in preschool children: A multicenter randomized controlled trial. Caries Research 54 (5-6):491–501. doi: 10.1159/000509926.
   PubMed Web of Science ®Google Scholar
• Piwat, S., R. Teanpaisan, S. Thitasomakul, A. Thearmontree, and G. Dahlen. 2010. Lactobacillus species and genotypes associated with dental caries in Thai preschool children. Molecular Oral Microbiology 25 (2):157–64. doi: 10.1111/j.2041-1014.2009.00556.x.
   PubMed Web of Science ®Google Scholar
• Piwat, S., N. Pahumunto, P. Srisommai, C. Mapaisansin, and R. Teanpaisan. 2019. Effect of probiotic delivery vehicles for probiotic Lactobacillus rhamnosus SD11 in caries prevention: A clinical study. Journal of Food Processing and Preservation 43 (10): 14147. doi: 10.1111/jfpp.14147.
   Web of Science ®Google Scholar
• Poureslami, H., L. Pishbin, Z. Eslaminejad, F. J. Moqadam, and M. Rashid Farokhi. 2013. The effects of a dairy probiotic product, espar, on salivary calcium and mutans streptococci. Journal of Dental Research, Dental Clinics, Dental Prospects 7 (3):147–51. doi: 10.5681/joddd.2013.023.
   PubMedGoogle Scholar
• Ratna Sudha, M., J. Neelamraju, M. S. Reddy, and M. Kumar. 2020. Evaluation of the Effect of Probiotic Bacillus coagulans Unique IS2 on Mutans Streptococci and Lactobacilli Levels in Saliva and Plaque: A Double-Blind, Randomized, Placebo-Controlled Study in Children. International Journal of Dentistry 2020:8891708. doi: 10.1155/2020/8891708.
   PubMed Web of Science ®Google Scholar
• Reddy, S., V. Madhu, R. Punithavathy, M. Satyam, U. K. Chowdary, and R. Mythraiye. 2021. Comparative evaluation of efficacy of kefir milk probiotic curd and probiotic drink on Streptococcus mutans in 8-12-year-old children: An in vivo study. International Journal of Clinical Pediatric Dentistry 14 (1):120–7. doi: 10.5005/jp-journals-10005-1883.
   PubMedGoogle Scholar
• Rodríguez, G., B. Ruiz, S. Faleiros, A. Vistoso, M. L. Marró, J. Sánchez, I. Urzúa, and R. Cabello. 2016. Probiotic compared with standard milk for high-caries children: A cluster randomized trial. Journal of Dental Research 95 (4):402–407. doi: 10.1177/0022034515623935.
   PubMed Web of Science ®Google Scholar
• Sandoval, F., S. Faleiros, R. Cabello, M. Díaz-Dosque, G. Rodríguez, and A. Escobar. 2021. The consumption of milk supplemented with probiotics decreases the occurrence of caries and the salivary concentration of hβD-3 in children. Clinical Oral Investigations 25 (6):3823–3830. doi: 10.1007/s00784-020-03712-8.
   PubMed Web of Science ®Google Scholar
• Selvarajan, N. B., S. K. Vasaviah, and R. Krishnan. 2020. A comparative study to evaluate the effects of probiotic curd on Streptococcus mutans, Bifidobacterium dentium, and pH of saliva in caries-free children: An in vivo study. Journal of Pharmacy & Bioallied Sciences 12 (Suppl 1):S129–S133. doi: 10.4103/jpbs.JPBS_42_20.
   PubMedGoogle Scholar
• Selwitz, R. H., A. I. Ismail, and N. B. Pitts. 2007. Dental caries. Lancet (London, England) 369 (9555):51–9. doi: 10.1016/S0140-6736(07)60031-2.
   PubMed Web of Science ®Google Scholar
• Seminario-Amez, M., J. Lopez-Lopez, A. Estrugo-Devesa, R. Ayuso-Montero, and E. Jane-Salas. 2017. Probiotics and oral health: A systematic review. Medicina Oral, Patologia Oral y Cirugia Bucal 22 (3):e282–e288. doi: 10.4317/medoral.21494.
   PubMed Web of Science ®Google Scholar
• Sharma, M., I. K. Pandit, N. Srivastava, N. Gugnani, and M. Gupta. 2018. A comparative evaluation of efficacy of Streptococcus mutans counts in saliva: An in vivo study. International Journal of Clinical Pediatric Dentistry 11 (2):94–9. doi: 10.5005/jp-journals-10005-1492.
   PubMedGoogle Scholar
• Sharma, S., S. Lavender, J. Woo, L. Guo, W. Shi, L. Kilpatrick-Liverman, and J. K. Gimzewski. 2014. Nanoscale characterization of effect of L-arginine on Streptococcus mutans biofilm adhesion by atomic force microscopy. Microbiology (Reading, England) 160 (Pt 7):1466–73. doi: 10.1099/mic.0.075267-0.
   PubMedGoogle Scholar
• Shimada, A., M. Noda, Y. Matoba, T. Kumagai, K. Kozai, and M. Sugiyama. 2015. Oral lactic acid bacteria related to the occurrence and/or progression of dental caries in Japanese preschool children. Bioscience of Microbiota, Food and Health 34 (2):29–36. doi: 10.12938/bmfh.2014-015.
   PubMedGoogle Scholar
• Sidhu, G. K., S. Mantha, S. Murthi, H. Sura, P. Kadaru, and J. K. Jangra. 2015. Evaluation of Lactobacillus and Streptococcus mutans by addition of probiotics in the form of curd in the diet. Journal of International Oral Health: JIOH 7 (7):85–9.
   PubMedGoogle Scholar
• Simark-Mattsson, C., C. G. Emilson, E. G. Hakansson, C. Jacobsson, K. Roos, and S. Holm. 2007. Lactobacillus-mediated interference of mutans streptococci in caries-free vs. caries-active subjects. European Journal of Oral Sciences 115 (4):308–14. doi: 10.1111/j.1600-0722.2007.00458.x.
   PubMed Web of Science ®Google Scholar
• Simon-Soro, A., P. Belda-Ferre, R. Cabrera-Rubio, L. D. Alcaraz, and A. Mira. 2013. A tissue-dependent hypothesis of dental caries. Caries Research 47 (6):591–600. doi: 10.1159/000351663.
   PubMed Web of Science ®Google Scholar
• Singh, R. P., S. G. Damle, and A. Chawla. 2011. Salivary mutans streptococci and lactobacilli modulations in young children on consumption of probiotic ice-cream containing Bifidobacterium lactis Bb12 and Lactobacillus acidophilus La5. Acta Odontologica Scandinavica 69 (6):389–394. doi: 10.3109/00016357.2011.572289.
   PubMed Web of Science ®Google Scholar
• Sounah, S. A., and A. A. Madfa. 2020. Correlation between dental caries experience and the level of Streptococcus mutans and lactobacilli in saliva and carious teeth in a Yemeni adult population. BMC Research Notes 13 (1):112. doi: 10.1186/s13104-020-04960-3.
   PubMed Web of Science ®Google Scholar
• Stensson, M., G. Koch, S. Coric, T. R. Abrahamsson, M. C. Jenmalm, D. Birkhed, and L. K. Wendt. 2014. Oral administration of Lactobacillus reuteri during the first year of life reduces caries prevalence in the primary dentition at 9 years of age. Caries Research 48 (2):111–117. doi: 10.1159/000354412.
   PubMed Web of Science ®Google Scholar
• Sudhir, R., P. Praveen, A. Anantharaj, and K. Venkataraghavan. 2012. Assessment of the effect of probiotic curd consumption on salivary pH and Streptococcus mutans counts. Nigerian Medical Journal 53 (3):135–9. doi: 10.4103/0300-1652.104382.
   PubMedGoogle Scholar
• Suzuki, N., M. Yoneda, K. Tanabe, A. Fujimoto, K. Iha, K. Seno, K. Yamada, T. Iwamoto, Y. Masuo, and T. Hirofuji. 2014. Lactobacillus salivarius WB21–containing tablets for the treatment of oral malodor: A double-blind, randomized, placebo-controlled crossover trial. Oral Surgery, Oral Medicine, Oral Pathology Oral Radiology 117 (4):462–70. doi: 10.1016/j.oooo.2013.12.400.
   PubMed Web of Science ®Google Scholar
• Taipale, T., K. Pienihäkkinen, P. Alanen, J. Jokela, and E. Söderling. 2013. Administration of Bifidobacterium animalis subsp. lactis BB-12 in early childhood: A post-trial effect on caries occurrence at four years of age. Caries Research 47 (5):364–372. doi: 10.1159/000348424.
   PubMed Web of Science ®Google Scholar
• Teanpaisan, R., and S. Piwat. 2014. Lactobacillus paracasei SD1, a novel probiotic, reduces mutans streptococci in human volunteers: A randomized placebo-controlled trial. Clinical Oral Investigations 18 (3):857–62. doi: 10.1007/s00784-013-1057-5.
   PubMed Web of Science ®Google Scholar
• Teanpaisan, R., S. Piwat, and G. Dahlen. 2011. Inhibitory effect of oral Lactobacillus against oral pathogens. Letters in Applied Microbiology 53 (4):452–9. doi: 10.1111/j.1472-765X.2011.03132.x.
   PubMed Web of Science ®Google Scholar
• Ten Cate, J. M., and M. A. R. Buzalaf. 2019. Fluoride mode of action: Once there was an observant dentist. Journal of Dental Research 98 (7):725–30. doi: 10.1177/0022034519831604.
   PubMed Web of Science ®Google Scholar
• Teughels, W., G. Loozen, and M. Quirynen. 2011. Do probiotics offer opportunities to manipulate the periodontal oral microbiota? Journal of Clinical Periodontology 38 Suppl 11:159–77. doi: 10.1111/j.1600-051X.2010.01665.x.
   PubMed Web of Science ®Google Scholar
• Villavicencio, J., L. M. Villegas, M. C. Arango, S. Arias, and F. Triana. 2018. Effects of a food enriched with probiotics on Streptococcus mutans and Lactobacillus spp. salivary counts in preschool children: A cluster randomized trial. Journal of Applied Oral Science 26:318. doi: 10.1590/1678-7757-2017-0318.
   Web of Science ®Google Scholar
• Wasfi, R., O. A. Abd El-Rahman, M. M. Zafer, and H. M. Ashour. 2018. Probiotic Lactobacillus sp. inhibit growth, biofilm formation and gene expression of caries-inducing Streptococcus mutans. Journal of Cellular and Molecular Medicine 22 (3):1972–83. doi: 10.1111/jcmm.13496.
   PubMed Web of Science ®Google Scholar
• Wattanarat, O., A. Makeudom, T. Sastraruji, S. Piwat, S. Tianviwat, R. Teanpaisan, and S. Krisanaprakornkit. 2015. Enhancement of salivary human neutrophil peptide 1-3 levels by probiotic supplementation. BMC Oral Health 15 (1):19. doi: 10.1186/s12903-015-0003-0.
   PubMedGoogle Scholar
• Wattanarat, O., A. Nirunsittirat, S. Piwat, C. Manmontri, R. Teanpaisan, N. Pahumunto, A. Makeudom, T. Sastraruji, and S. Krisanaprakornkit. 2021. Significant elevation of salivary human neutrophil peptides 1-3 levels by probiotic milk in preschool children with severe early childhood caries: A randomized controlled trial. Clinical Oral Investigations 25 (5):2891–2903. doi: 10.1007/s00784-020-03606-9.
   PubMed Web of Science ®Google Scholar
• Yadav, M., P. Poornima, N. M. Roshan, N. Prachi, M. Veena, and I. E. Neena. 2014. Evaluation of probiotic milk on salivary mutans streptococci count: An in vivo microbiological study. The Journal of Clinical Pediatric Dentistry 39 (1):23–26. doi: 10.17796/jcpd.39.1.u433n8w245511781.
   PubMed Web of Science ®Google Scholar
• Yu, Y., X. Wang, C. Ge, B. Wang, C. Cheng, and Y. H. Gan. 2017. Effects of rinsing with arginine bicarbonate and urea solutions on initial enamel lesions in situ. Oral Diseases 23 (3):353–9. doi: 10.1111/odi.12618.
   PubMed Web of Science ®Google Scholar