Emerging pre-clinical safety assessments for potential probiotic strains: a review

References

• Abe, F., M. Muto, T. Yaeshima, K. Iwatsuki, H. Aihara, Y. Ohashi, and T. Fujisawa. 2010. Safety evaluation of probiotic bifidobacteria by analysis of mucin degradation activity and translocation ability. Anaerobe 16 (2):131–6. doi: 10.1016/j.anaerobe.2009.07.006.
   PubMed Web of Science ®Google Scholar
• Adawi, D., G. Molin, S. Ahrné, and B. Jeppsson. 2002. Safety of the probiotic strain Lactobacillus plantarum DSM 9843 (strain 299v) in an endocarditis animal model. Microbial Ecology in Health and Disease 14 (1):50–3. doi: 10.1080/089106002760002766.
   Google Scholar
• Agrawal, S., E. S. Tuchman, M. J. Bruce, and M. E. Theodorou. 2020. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Reports 13 (11):e236835. doi: 10.1136/bcr-2020-236835.
   PubMedGoogle Scholar
• Ajam, M., O. Adam, A. Yeddi, M. Kahlid, M. Shokr, and L. Afonso. 2019. Prosthetic aortic valve endocarditis in a patient with Birt-Hogg-Dube syndrome due to Lactobacillus paracasei. Cardiology Research 10 (4):245–8. doi: 10.14740/cr901.
   PubMedGoogle Scholar
• Alayande, K. A., O. A. Aiyegoro, T. M. Nengwekhulu, L. Katata-Seru, and C. N. Ateba. 2020. Integrated genome-based probiotic relevance and safety evaluation of Lactobacillus reuteri PNW1. Plos ONE 15 (7):e0235873. doi: 10.1371/journal.pone.0235873.
   PubMed Web of Science ®Google Scholar
• AlGburi, A., A. Volski, C. Cugini, E. M. Walsh, V. A. Chistyakov, M. S. Mazanko, A. B. Bren, L. M. Dicks, and M. L. Chikindas. 2016. Safety properties and probiotic potential of Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895. Advances in Microbiology 06 (06):432–52. doi: 10.4236/aim.2016.66043.
   Google Scholar
• Ambesh, P., S. Stroud, E. Franzova, J. Gotesman, K. Sharma, L. Wolf, and S. Kamholz. 2017. Recurrent Lactobacillus bacteremia in a patient with leukemia. Journal of Investigative Medicine High Impact Case Reports 5 (4):2324709617744233. doi: 10.1177/2324709617744233.
   Google Scholar
• Ammor, M. S., A. B. Flórez, A. H. Van Hoek, C. G. De Los Reyes-Gavilán, H. J. Aarts, A. Margolles, and B. Mayo. 2008. Molecular characterization of intrinsic and acquired antibiotic resistance in lactic acid bacteria and bifidobacteria. Journal of Molecular Microbiology and Biotechnology 14 (1–3):6–15. doi: 10.1159/000106077.
   PubMed Web of Science ®Google Scholar
• An, H., F. P. Douillard, G. Wang, Z. Zhai, J. Yang, S. Song, J. Cui, F. Ren, Y. Luo, B. Zhang, et al. 2014. Integrated transcriptomic and proteomic analysis of the bile stress response in a centenarian-originated probiotic Bifidobacterium longum BBMN68. Molecular & Cellular Proteomics : MCP 13 (10):2558–72. doi: 10.1074/mcp.M114.039156.
   PubMedGoogle Scholar
• Apostolakos, I., S. Paramithiotis, and M. Mataragas. 2022. Functional and safety characterization of Weissella paramesenteroides strains isolated from dairy products through whole-genome sequencing and comparative genomics. Dairy 3 (4):799–813. doi: 10.3390/dairy3040055.
   Google Scholar
• Arellano, K., J. Vazquez, H. Park, J. Lim, Y. Ji, H. J. Kang, D. Cho, H. W. Jeong, and W. H. Holzapfel. 2020. Safety evaluation and whole-genome annotation of Lactobacillus plantarum strains from different sources with special focus on isolates from green tea. Probiotics and Antimicrobial Proteins 12 (3):1057–70. doi: 10.1007/s12602-019-09620-y.
   PubMed Web of Science ®Google Scholar
• Aristimuño Ficoseco, C., F. I. Mansilla, N. C. Maldonado, H. Miranda, M. E. Fátima Nader-Macias, and G. M. Vignolo. 2018. Safety and growth optimization of lactic acid bacteria isolated from feedlot cattle for probiotic formula design. Frontiers in Microbiology 9:2220. doi: 10.3389/fmicb.2018.02220.
   PubMedGoogle Scholar
• Aryantini, N. P. D., E. Yamasaki, H. Kurazono, IN. Sujaya, T. Urashima, and K. Fukuda. 2017. In vitro safety assessments and antimicrobial activities of Lactobacillus rhamnosus strains isolated from a fermented mare’s milk. Animal Science Journal = Nihon Chikusan Gakkaiho 88 (3):517–25. doi: 10.1111/asj.12668.
   PubMedGoogle Scholar
• Asan-Ozusaglam, M., and A. Gunyakti. 2021. A new probiotic candidate bacterium from human milk: Limosilactobacillus vaginalis MA-10. Acta Alimentaria 50 (1):13–21. doi: 10.1556/066.2020.00073.
   Google Scholar
• Aydoğan, S., D. Dilli, A. Özyazici, N. Aydin, H. Şimşek, U. A. Orun, and Ö. N. Aksoy. 2022. Lactobacillus rhamnosus sepsis associated with probiotic therapy in a term infant with congenital heart disease. Fetal and Pediatric Pathology 41 (5):823–7. doi: 10.1080/15513815.2021.1966144.
   PubMedGoogle Scholar
• Aziz, T., M. Naveed, A. Sarwar, S. I. Makhdoom, M. S. Mughal, U. Ali, Z. Yang, M. Shahzad, M. Y. Sameeh, M. W. Alruways, et al. 2022. Functional annotation of Lactiplantibacillus plantarum 13-3 as a potential starter probiotic involved in the food safety of fermented products. Molecules 27 (17):5399. doi: 10.3390/molecules27175399.
   PubMed Web of Science ®Google Scholar
• Bahrevar, S., A. A. Barzegari, S. Khezri, and V. Nejati. 2021a. Safety assessment of Lactobacillus paracasei IBRC-M 11110 in Wistar rats: A subacute 28-day toxicity study. Medical Laboratory Journal 15:19–26.
   Google Scholar
• Bahrehvar, S., S. Khezri, A. A. Barzegari, and V. Nejati. 2021b. Safety assessment of a new strain of Lactobacillus pentosus (IBRC = 11143) as a candidate probiotic. Pharmaceutical and Biomedical Research 7:37–46. doi: 10.18502/pbr.v7i1.7355.
   Google Scholar
• Baker, L. M., T. S. Webberley, G. Masetti, T. R. Hughes, J. R. Marchesi, A. A. Jack, T. S. C. Joyce, M. D. Allen, S. F. Plummer, D. R. Michael, et al. 2021. A genome guided evaluation of the Lab4 probiotic consortium. Genomics 113 (6):4028–38. doi: 10.1016/j.ygeno.2021.08.007.
   PubMedGoogle Scholar
• Baltz, R. H. 2018. Bacteriophage-resistant industrial fermentation strains: From the cradle to CRISPR/Cas9. Journal of Industrial Microbiology & Biotechnology 45 (11):1003–6. doi: 10.1007/s10295-018-2079-4.
   PubMedGoogle Scholar
• Banerjee, G., A. Nandi, and A. K. Ray. 2017. Assessment of hemolytic activity, enzyme production and bacteriocin characterization of Bacillus subtilis LR1 isolated from the gastrointestinal tract of fish. Archives of Microbiology 199 (1):115–24. doi: 10.1007/s00203-016-1283-8.
   PubMedGoogle Scholar
• Bang, W. Y., O. H. Ban, B. S. Lee, S. Oh, C. Park, M. K. Park, S. K. Jung, J. Yang, and Y. H. Jung. 2021. Genomic-, phenotypic-, and toxicity-based safety assessment and probiotic potency of Bacillus coagulans IDCC 1201 isolated from green malt. Journal of Industrial Microbiology and Biotechnology 48:026. doi: 10.1093/jimb/kuab026.
   Google Scholar
• Belloso Daza, M. V., G. Milani, C. Cortimiglia, E. Pietta, D. Bassi, and P. S. Cocconcelli. 2022. Genomic insights of Enterococcus faecium UC7251, a multi-drug resistant strain from ready-to-eat food, highlight the risk of antimicrobial resistance in the food chain. Frontiers in Microbiology 13:894241. doi: 10.3389/fmicb.2022.894241.
   PubMedGoogle Scholar
• Bhardwaj, A., H. Gupta, S. Kapila, G. Kaur, S. Vij, and R. K. Malik. 2010. Safety assessment and evaluation of probiotic potential of bacteriocinogenic Enterococcus faecium KH 24 strain under in vitro and in vivo conditions. International Journal of Food Microbiology 141 (3):156–64. doi: 10.1016/j.ijfoodmicro.2010.05.001.
   PubMedGoogle Scholar
• Bharti, V., A. Mehta, S. Singh, N. Jain, and L. Ahirwal. 2015. Cytotoxicity of live whole cell, heat killed cell and cell free extract of Lactobacillus strain in U-87 human glioblastoma cell line and MCF-7 breast cancer cell line. International Journal of Probiotics & Prebiotics 10:153–8.
   Google Scholar
• Bhat, M. I., V. K. Singh, D. Sharma, S. Kapila, and R. Kapila. 2019. Adherence capability and safety assessment of an indigenous probiotic strain Lactobacillus rhamnosus MTCC-5897. Microbial Pathogenesis 130:120–30. doi: 10.1016/j.micpath.2019.03.009.
   PubMedGoogle Scholar
• Bianchi, L., L. Laghi, V. Correani, E. Schifano, C. Landi, D. Uccelletti, and B. Mattei. 2020. A combined proteomics, metabolomics and in vivo analysis approach for the characterization of probiotics in large-scale production. Biomolecules 10 (1):157. doi: 10.3390/biom10010157.
   PubMedGoogle Scholar
• Birri, D. J., D. A. Brede, G. T. Tessema, and I. F. Nes. 2013. Bacteriocin production, antibiotic susceptibility and prevalence of haemolytic and gelatinase activity in faecal lactic acid bacteria isolated from healthy Ethiopian infants. Microbial Ecology 65 (2):504–16. doi: 10.1007/s00248-012-0134-7.
   PubMedGoogle Scholar
• Bonham, K. S., B. E. Wolfe, and R. J. Dutton. 2017. Extensive horizontal gene transfer in cheese-associated bacteria. eLife 6:22144. doi: 10.7554/eLife.22144.
   Google Scholar
• Boumis, E., A. Capone, V. Galati, C. Venditti, and N. Petrosillo. 2018. Probiotics and infective endocarditis in patients with hereditary hemorrhagic telangiectasia: A clinical case and a review of the literature. BMC Infectious Diseases 18 (1):65. doi: 10.1186/s12879-018-2956-5.
   PubMedGoogle Scholar
• Božič, J. T., L. Butinar, M. B. Marušič, D. Korte, and B. M. Vodopivec. 2022. Determination of biogenic amines formation by autochthonous lactic acid bacteria from ‘Refošk’grapes using different analytical methods. LWT 156:112908. doi: 10.1016/j.lwt.2021.112908.
   Google Scholar
• Bunesova, V., C. Lacroix, and C. Schwab. 2018. Mucin cross-feeding of infant bifidobacteria and Eubacterium hallii. Microbial Ecology 75 (1):228–38. doi: 10.1007/s00248-017-1037-4.
   PubMedGoogle Scholar
• Campagne, J., J. F. Guichard, M. C. Moulhade, H. Kawski, and F. Maurier. 2020. Lactobacillus endocarditis: A case report in France and literature review. IDCases 21:e00811. doi: 10.1016/j.idcr.2020.e00811.
   PubMedGoogle Scholar
• Casarotti, S. N., B. M. Carneiro, S. D. Todorov, L. A. Nero, P. Rahal, and A. L. B. Penna. 2017. In vitro assessment of safety and probiotic potential characteristics of Lactobacillus strains isolated from water buffalo mozzarella cheese. Annals of Microbiology 67 (4):289–301. doi: 10.1007/s13213-017-1258-2.
   Google Scholar
• Chakravarty, S., A. Parashar, and S. Acharyya. 2019. Saccharomyces cerevisiae sepsis following probiotic therapy in an infant. Indian Pediatrics 56 (11):971–2. doi: 10.1007/s13312-019-1655-7.
   PubMedGoogle Scholar
• Cherifi, S., J. Robberecht, and Y. Miendje. 2004. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clinica Belgica 59 (4):223–4. doi: 10.1179/acb.2004.033.
   PubMed Web of Science ®Google Scholar
• Chiang, M. C., C. L. Chen, Y. Feng, C. C. Chen, R. Lien, and C. H. Chiu. 2021. Lactobacillus rhamnosus sepsis associated with probiotic therapy in an extremely preterm infant: Pathogenesis and a review for clinicians. Journal of Microbiology, Immunology, and Infection = Wei Mian yu Gan Ran za Zhi 54 (4):575–80. doi: 10.1016/j.jmii.2020.03.029.
   PubMedGoogle Scholar
• Chiu, Y. J., M. K. Nam, Y. T. Tsai, C. C. Huang, and C. C. Tsai. 2013. Genotoxicity assessment of multispecies probiotics using reverse mutation, mammalian chromosomal aberration, and rodent micronucleus tests. The Scientific World Journal 2013:1–7. doi: 10.1155/2013/254239.
   Google Scholar
• Chokesajjawatee, N., P. Santiyanont, K. Chantarasakha, K. Kocharin, C. Thammarongtham, S. Lertampaiporn, T. Vorapreeda, T. Srisuk, T. Wongsurawat, P. Jenjaroenpun, et al. 2020. Safety assessment of a nham starter culture Lactobacillus plantarum BCC9546 via whole-genome analysis. Scientific Reports 10 (1):12. doi: 10.1038/s41598-020-66857-2.
   PubMedGoogle Scholar
• Cirrincione, S., B. Neumann, D. Zühlke, K. Riedel, and E. Pessione. 2019. Detailed soluble proteome analyses of a dairy-isolated Enterococcus faecalis: A possible approach to assess food safety and potential probiotic value. Frontiers in Nutrition 6:71. doi: 10.3389/fnut.2019.00071.
   PubMedGoogle Scholar
• Colautti, A., M. Arnoldi, G. Comi, and L. Iacumin. 2022. Antibiotic resistance and virulence factors in lactobacilli: Something to carefully consider. Food Microbiology 103:103934. doi: 10.1016/j.fm.2021.103934.
   PubMedGoogle Scholar
• Collins, J., J.-P. van Pijkeren, L. Svensson, M. J. Claesson, M. Sturme, Y. Li, J. C. Cooney, D. van Sinderen, A. W. Walker, J. Parkhill, et al. 2012. Fibrinogen-binding and platelet-aggregation activities of a Lactobacillus salivarius septicaemia isolate are mediated by a novel fibrinogen-binding protein. Molecular Microbiology 85 (5):862–77. doi: 10.1111/j.1365-2958.2012.08148.x.
   PubMedGoogle Scholar
• Comerlato, C. B., X. Zhang, K. Walker, A. Brandelli, and D. Figeys. 2020. Comparative proteomic analysis reveals metabolic variability of probiotic Enterococcus durans during aerobic and anaerobic cultivation. Journal of Proteomics 220:103764. doi: 10.1016/j.jprot.2020.103764.
   PubMedGoogle Scholar
• Corfield, A. P. 2018. The interaction of the gut microbiota with the mucus barrier in health and disease in human. Microorganisms 6 (3):78. doi: 10.3390/microorganisms6030078.
   PubMed Web of Science ®Google Scholar
• Cuffaro, B., A. L. Assohoun, D. Boutillier, L. Súkeníková, J. Desramaut, S. Boudebbouze, S. Salomé-Desnoulez, J. Hrdý, A. J. Waligora-Dupriet, E. Maguin, et al. 2020. In vitro characterization of gut microbiota-derived commensal strains: Selection of Parabacteroides distasonis strains alleviating TNBS-induced colitis in mice. Cells 9 (9):2104. doi: 10.3390/cells9092104.
   PubMed Web of Science ®Google Scholar
• Cui, Y., S. Wang, S. Ding, J. Shen, and K. Zhu. 2020. Toxins and mobile antimicrobial resistance genes in Bacillus probiotics constitute a potential risk for One Health. Journal of Hazardous Materials 382:121266. doi: 10.1016/j.jhazmat.2019.121266.
   PubMedGoogle Scholar
• Dela Cruz, T. E. E., and J. M. O. Torres. 2012. Gelatin hydrolysis test protocol. American Society of Microbiology :1–10.
   Google Scholar
• Deng, F., Y. Chen, T. Sun, Y. Wu, Y. Su, C. Liu, J. Zhou, Y. Deng, and J. Wen. 2021. Antimicrobial resistance, virulence characteristics and genotypes of Bacillus spp. from probiotic products of diverse origins. Food Research International (Ottawa, Ont.) 139:109949. doi: 10.1016/j.foodres.2020.109949.
   PubMedGoogle Scholar
• Diehl, R., F. Ferrara, C. Müller, A. Y. Dreyer, D. D. McLeod, S. Fricke, and J. Boltze. 2017. Immunosuppression for in vivo research: State-of-the-art protocols and experimental approaches. Cellular & Molecular Immunology 14 (2):146–79. doi: 10.1038/cmi.2016.39.
   PubMed Web of Science ®Google Scholar
• Divisekera, D. M., J. K. R. Samarasekera, C. Hettiarachchi, R. Maharjan, J. Gooneratne, M. Iqbal Choudhary, S. Gopalakrishnan, A. Wahab, and S. D. Mazumdar. 2021. Oral toxicity evaluation of probiotic strains isolated from Finger millet [Eleusine coracana (L.) Gaertn.] in Wistar rat models (in vivo). Archives of Ecotoxicology 3 (3):91–102. doi: 10.36547/ae.2021.3.3.91-102.
   Google Scholar
• Dlamini, Z. C., R. L. Langa, O. A. Aiyegoro, and A. I. Okoh. 2019. Safety evaluation and colonisation abilities of four lactic acid bacteria as future probiotics. Probiotics and Antimicrobial Proteins 11 (2):397–402. doi: 10.1007/s12602-018-9430-y.
   PubMedGoogle Scholar
• Doeun, D., M. Davaatseren, and M. S. Chung. 2017. Biogenic amines in foods. Food Science and Biotechnology 26 (6):1463–74. doi: 10.1007/s10068-017-0239-3.
   PubMed Web of Science ®Google Scholar
• dos Santos, C. I., C. D. L. Campos, W. R. Nunes-Neto, M. S. do Carmo, F. A. B. Nogueira, R. M. Ferreira, E. P. S. Costa, L. F. Gonzaga, J. M. M. Araújo, J. M. Monteiro, et al. 2021. Genomic analysis of Limosilactobacillus fermentum ATCC 23271, a potential probiotic strain with anti-candida activity. Journal of Fungi 7 (10):794. doi: 10.3390/jof7100794.
   Google Scholar
• Druart, C., H. Plovier, M. Van Hul, A. Brient, K. R. Phipps, W. M. de Vos, and P. D. Cani. 2021. Toxicological safety evaluation of pasteurized Akkermansia muciniphila. Journal of Applied Toxicology : JAT 41 (2):276–90. doi: 10.1002/jat.4044.
   PubMedGoogle Scholar
• Dubbert, S., B. Klinkert, M. Schimiczek, T. M. Wassenaar, and R. V. Bünau. 2020. No genotoxicity is detectable for Escherichia coli strain Nissle 1917 by standard in vitro and in vivo tests. European Journal of Microbiology & Immunology 10 (1):11–9. doi: 10.1556/1886.2019.00025.
   PubMedGoogle Scholar
• EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP). 2012. Guidance on the assessment of bacterial susceptibility to antimicrobials of human and veterinary importance. EFSA Journal 10:2740.
   Google Scholar
• Egan, M., M. O’Connell Motherway, M. Kilcoyne, M. Kane, L. Joshi, M. Ventura, and D. Van Sinderen. 2014. Cross-feeding by Bifidobacterium breve UCC2003 during co-cultivation with Bifidobacterium bifidum PRL2010 in a mucin-based medium. BMC Microbiology 14 (1):14. doi: 10.1186/s12866-014-0282-7.
   PubMedGoogle Scholar
• Endo, K., Y. Mine, T. Shuto, T. Taji, T. Murayama, and H. Nikawa. 2020. Comprehensive analysis of transcriptional profiles in oral epithelial-like cells stimulated with oral probiotic Lactobacillus spp. Archives of Oral Biology 118:104832. doi: 10.1016/j.archoralbio.2020.104832.
   PubMedGoogle Scholar
• Endres, J. R., I. Qureshi, T. Farber, J. Hauswirth, G. Hirka, I. Pasics, and A. G. Schauss. 2011. One-year chronic oral toxicity with combined reproduction toxicity study of a novel probiotic, Bacillus coagulans, as a food ingredient. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 49 (5):1174–82. doi: 10.1016/j.fct.2011.02.012.
   PubMed Web of Science ®Google Scholar
• Erginkaya, Z., E. U. Turhan, and D. Tatlı. 2018. Determination of antibiotic resistance of lactic acid bacteria isolated from traditional Turkish fermented dairy products. Iranian Journal of Veterinary Research 19:53.
   PubMed Web of Science ®Google Scholar
• Fareez, I. M., S. M. Lim, and K. Ramasamy. 2019. Microencapsulated Lactobacillus plantarum LAB12 showed no sign of acute or sub-chronic toxicity in vivo. Probiotics and Antimicrobial Proteins 11 (2):447–59. doi: 10.1007/s12602-018-9442-7.
   PubMedGoogle Scholar
• Fatahi-Bafghi, M., S. Naseri, and A. Alizehi. 2022. Genome analysis of probiotic bacteria for antibiotic resistance genes. Antonie Van Leeuwenhoek 115 (3):375–89. doi: 10.1007/s10482-021-01703-7.
   PubMedGoogle Scholar
• Fernández-Murga, M. L., and Y. Sanz. 2016. Safety assessment of Bacteroides uniformis CECT 7771 isolated from stools of healthy breast-fed infants. Plos ONE 11 (1):e0145503. doi: 10.1371/journal.pone.0145503.
   PubMed Web of Science ®Google Scholar
• Fochesato, A. S., M. P. Martínez, F. S. Escobar, G. García, C. A. Dogi, and L. R. Cavaglieri. 2020. Cytotoxicity in Vero cells and cytokines analyses in Balb/c mice as safety assessments of the probiotic mixture Saccharomyces cerevisiae RC016 and Lactobacillus rhamnosus RC007 for use as a feed additive. Letters in Applied Microbiology 71 (4):400–4. doi: 10.1111/lam.13357.
   PubMedGoogle Scholar
• Fu, X., L. Lyu, Y. Wang, Y. Zhang, X. Guo, Q. Chen, and C. Liu. 2022. Safety assessment and probiotic characteristics of Enterococcus lactis JDM1. Microbial Pathogenesis 163:105380. doi: 10.1016/j.micpath.2021.105380.
   PubMedGoogle Scholar
• García, E. A., N. Benomar, L. L. Lerma, J. J. de la Fuente Ordoñez, C. W. Knapp, and H. Abriouel. 2023. Changes in resistome profile of potential probiotic Lactiplantibacillus pentosus in response to edible oil adaptation. Food Microbiology 109:104148. doi: 10.1016/j.fm.2022.104148.
   PubMedGoogle Scholar
• Gerceker, D., D. Karasartova, E. Elyürek, S. Barkar, M. KIyan, T. M. Özsan, M. K. Calgin, and F. Sahin. 2009. A new, simple, rapid test for detection of DNase activity of microorganisms: DNase Tube test. The Journal of General and Applied Microbiology 55 (4):291–4. doi: 10.2323/jgam.55.291.
   PubMed Web of Science ®Google Scholar
• Gómez del Pulgar, E. M., A. Benítez-Páez, and Y. Sanz. 2020. Safety assessment of Bacteroides uniformis CECT 7771, a symbiont of the gut microbiota in infants. Nutrients 12 (2):551. doi: 10.3390/nu12020551.
   PubMedGoogle Scholar
• González Pereyra, M. L., C. Dogi, A. Torres Lisa, P. Wittouck, M. Ortíz, F. Escobar, G. Bagnis, R. Yaciuk, L. Poloni, A. Torres, et al. 2014. Genotoxicity and cytotoxicity evaluation of probiotic Saccharomyces cerevisiae RC 016: A 60‐day subchronic oral toxicity study in rats. Journal of Applied Microbiology 117 (3):824–33. doi: 10.1111/jam.12552.
   PubMedGoogle Scholar
• Gorbach, S., S. Doron, and F. Magro. 2017. Lactobacillus rhamnosus GG. In The microbiota in gastrointestinal pathophysiology, eds. M. H. Floch, Y. Ringel and W. A. Walker, 79–88. London: Academic Press.
   Google Scholar
• Gueimonde, M., B. Sánchez, C. G. de los Reyes-Gavilán, and A. Margolles. 2013. Antibiotic resistance in probiotic bacteria. Frontiers in Microbiology 4:202. doi: 10.3389/fmicb.2013.00202.
   PubMed Web of Science ®Google Scholar
• Gupta, S. K., B. R. Padmanabhan, S. M. Diene, R. Lopez-Rojas, M. Kempf, L. Landraud, and J. M. Rolain. 2014. ARG-ANNOT, a new bioinformatic tool to discover antibiotic resistance genes in bacterial genomes. Antimicrobial Agents and Chemotherapy 58 (1):212–20. doi: 10.1128/AAC.01310-13.
   PubMed Web of Science ®Google Scholar
• Haghighat, L., and N. F. Crum-Cianflone. 2016. The potential risks of probiotics among HIV-infected persons: Bacteraemia due to Lactobacillus acidophilus and review of the literature. International Journal of STD & AIDS 27 (13):1223–30. doi: 10.1177/0956462415590725.
   PubMed Web of Science ®Google Scholar
• Han, J. S., S. M. Back, J. W. Cho, H. J. Park, W. J. Kim, S. H. Park, J. H. Noh, Y. B. Kim, and B. S. Lee. 2021. Genotoxicity and subchronic general toxicity assessments of Lactobacillus curvatus WiKim 38 using Sprague-Dawley rats. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 152:112199. doi: 10.1016/j.fct.2021.112199.
   PubMedGoogle Scholar
• Haryani, Y., N. A. Halid, G. S. Guat, M. A. R. Nor-Khaizura, M. A. M. Hatta, S. Sabri, S. Radu, and H. Hasan. 2023. High prevalence of multiple antibiotic resistance in fermented food-associated lactic acid bacteria in Malaysia. Food Control 147:109558. doi: 10.1016/j.foodcont.2022.109558.
   Google Scholar
• Hassan, H., M. Rompola, A. W. Glaser, S. E. Kinsey, and R. S. Phillips. 2018. Systematic review and meta-analysis investigating the efficacy and safety of probiotics in people with cancer. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer 26 (8):2503–9. doi: 10.1007/s00520-018-4216-z.
   PubMed Web of Science ®Google Scholar
• Hossain, T. J. 2022. Functional genomics of the lactic acid bacterium Limosilactobacillus fermentum LAB-1: Metabolic, probiotic and biotechnological perspectives. Heliyon 8 (11):e11412. doi: 10.1016/j.heliyon.2022.e11412.
   PubMed Web of Science ®Google Scholar
• Hummel, A. S., C. Hertel, W. H. Holzapfel, and C. M. Franz. 2007. Antibiotic resistances of starter and probiotic strains of lactic acid bacteria. Applied and Environmental Microbiology 73 (3):730–9. doi: 10.1128/AEM.02105-06.
   PubMed Web of Science ®Google Scholar
• Isa, K., K. Oka, N. Beauchamp, M. Sato, K. Wada, K. Ohtani, S. Nakanishi, E. McCartney, M. Tanaka, T. Shimizu, et al. 2016. Safety assessment of the Clostridium butyricum MIYAIRI 588® probiotic strain including evaluation of antimicrobial sensitivity and presence of Clostridium toxin genes in vitro and teratogenicity in vivo. Human & Experimental Toxicology 35 (8):818–32. doi: 10.1177/0960327115607372.
   PubMedGoogle Scholar
• Jagadeesan, B., P. Gerner-Smidt, M. W. Allard, S. Leuillet, A. Winkler, Y. Xiao, S. Chaffron, J. Van Der Vossen, S. Tang, M. Katase, et al. 2019. The use of next generation sequencing for improving food safety: Translation into practice. Food Microbiology 79:96–115. doi: 10.1016/j.fm.2018.11.005.
   PubMed Web of Science ®Google Scholar
• Joossens, M., G. Huys, M. Cnockaert, V. De Preter, K. Verbeke, P. Rutgeerts, P. Vandamme, and S. Vermeire. 2011. Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives. Gut 60 (5):631–7. doi: 10.1136/gut.2010.223263.
   PubMed Web of Science ®Google Scholar
• Junior, W., A. F. Guerra, A. Tarrah, V. da Silva Duarte, A. Giacomini, R. H. Luchese, and V. Corich. 2020. Safety and stability of two potentially probiotic lactobacillus strains after in vitro gastrointestinal transit. Probiotics and Antimicrobial Proteins 12 (2):657–66. doi: 10.1007/s12602-019-09565-2.
   PubMedGoogle Scholar
• Kang, M. S., J. E. Yeu, and S. P. Hong. 2019. Safety evaluation of oral care probiotics Weissella cibaria CMU and CMS1 by phenotypic and genotypic analysis. International Journal of Molecular Sciences 20 (11):2693. doi: 10.3390/ijms20112693.
   PubMedGoogle Scholar
• Kato, K., N. Funabashi, H. Takaoka, H. Kohno, T. Kishimoto, Y. Nakatani, G. Matsumiya, and Y. Kobayashi. 2016. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. International Journal of Cardiology 224:157–61. doi: 10.1016/j.ijcard.2016.09.002.
   PubMed Web of Science ®Google Scholar
• Khaled, J. M., F. A. Al-Mekhlafi, R. A. Mothana, N. S. Alharbi, K. E. Alzaharni, A. H. Sharafaddin, S. Kadaikunnan, A. S. Alobaidi, N. I. Bayaqoob, M. Govindarajan, et al. 2018. Brevibacillus laterosporus isolated from the digestive tract of honeybees has high antimicrobial activity and promotes growth and productivity of honeybee’s colonies. Environmental Science and Pollution Research International 25 (11):10447–55. doi: 10.1007/s11356-017-0071-6.
   PubMed Web of Science ®Google Scholar
• Khalkhali, S., and N. Mojgani. 2018. In vitro and in vivo safety analysis of Enterococcus faecium 2C isolated from human breast milk. Microbial Pathogenesis 116:73–7. doi: 10.1016/j.micpath.2018.01.012.
   PubMedGoogle Scholar
• Kim, K. M., T. S. Jung, S. Ok, C. Y. Ko, and J. S. Kang. 2012. Evaluation of genotoxicity of Bacillus mojavensis KJS-3 on culture supernatant for use as a probiotic. Molecular & Cellular Toxicology 8 (1):77–81. doi: 10.1007/s13273-012-0010-z.
   Google Scholar
• Kim, K. T., S. J. Yang, and H. D. Paik. 2021. Probiotic properties of novel probiotic Levilactobacillus brevis KU15147 isolated from radish kimchi and its antioxidant and immune-enhancing activities. Food Science and Biotechnology 30 (2):257–65. doi: 10.1007/s10068-020-00853-0.
   PubMedGoogle Scholar
• Kochan, P., A. Chmielarczyk, L. Szymaniak, M. Brykczynski, K. Galant, A. Zych, K. Pakosz, S. Giedrys-Kalemba, E. Lenouvel, and P. B. Heczko. 2011. Lactobacillus rhamnosus administration causes sepsis in a cardiosurgical patient—is the time right to revise probiotic safety guidelines? Clinical Microbiology and Infection : The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 17 (10):1589–92. doi: 10.1111/j.1469-0691.2011.03614.x.
   PubMed Web of Science ®Google Scholar
• Kojic, M., B. Jovcic, M. Miljkovic, K. Novovic, J. Begovic, and D. J. Studholme. 2020. Large-scale chromosome flip-flop reversible inversion mediates phenotypic switching of expression of antibiotic resistance in lactococci. Microbiological Research 241:126583. doi: 10.1016/j.micres.2020.126583.
   PubMedGoogle Scholar
• Koppel, N., V. M. Rekdal, and E. P. Balskus. 2017. Chemical transformation of xenobiotics by the human gut microbiota. Science 356 (6344):2770. doi: 10.1126/science.aag2770.
   Google Scholar
• Koskenniemi, K., K. Laakso, J. Koponen, M. Kankainen, D. Greco, P. Auvinen, K. Savijoki, T. A. Nyman, A. Surakka, T. Salusjärvi, et al. 2011. Proteomics and transcriptomics characterization of bile stress response in probiotic Lactobacillus rhamnosus GG. Molecular & Cellular Proteomics 10 (2):S1–S18. doi: 10.1074/mcp.M110.002741.
   Google Scholar
• Kothari, D., S. Patel, and S. K. Kim. 2019. Probiotic supplements might not be universally-effective and safe: A review. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 111:537–47. doi: 10.1016/j.biopha.2018.12.104.
   PubMed Web of Science ®Google Scholar
• Ku, S., S. Yang, H. H. Lee, D. Choe, T. V. Johnston, G. E. Ji, and M. S. Park. 2020. Biosafety assessment of Bifidobacterium animalis subsp. lactis AD011 used for human consumption as a probiotic microorganism. Food Control. 117:106985. doi: 10.1016/j.foodcont.2019.106985.
   Web of Science ®Google Scholar
• Lee, B. S., O. H. Ban, W. Y. Bang, S. A. Chae, S. Oh, C. Park, M. Lee, S. J. Kim, J. Yang, and Y. H. Jung. 2021. Safety assessment of Lactobacillus reuteri IDCC 3701 based on phenotypic and genomic analysis. Annals of Microbiology 71 (1):6. doi: 10.1186/s13213-021-01622-y.
   Google Scholar
• Lee, N. K., W. S. Kim, and H. D. Paik. 2019. Bacillus strains as human probiotics: Characterization, safety, microbiome, and probiotic carrier. Food Science and Biotechnology 28 (5):1297–305. doi: 10.1007/s10068-019-00691-9.
   PubMed Web of Science ®Google Scholar
• Lengliz, S., M. S. Abbassi, A. Rehaiem, N. Ben Chehida, and T. Najar. 2021. Characterization of bacteriocinogenic Enterococcus isolates from wild and laboratory rabbits for the selection of autochthonous probiotic strains in Tunisia. Journal of Applied Microbiology 131 (3):1474–86. doi: 10.1111/jam.15047.
   PubMedGoogle Scholar
• Li, B., D. Jin, S. Etareri Evivie, N. Li, F. Yan, L. Zhao, F. Liu, and G. Huo. 2017. Safety assessment of Lactobacillus helveticus KLDS1. 8701 based on whole genome sequencing and oral toxicity studies. Toxins 9 (10):301. doi: 10.3390/toxins9100301.
   PubMedGoogle Scholar
• Li, B., M. Zhan, S. E. Evivie, D. Jin, L. Zhao, S. Chowdhury, S. K. Sarker, G. Huo, and F. Liu. 2018. Evaluating the safety of potential probiotic Enterococcus durans KLDS6. 0930 using whole genome sequencing and oral toxicity study. Frontiers in Microbiology 9:1943. doi: 10.3389/fmicb.2018.01943.
   PubMedGoogle Scholar
• Li, M., Y. Wang, H. Cui, Y. Li, Y. Sun, and H. J. Qiu. 2020. Characterization of lactic acid Bacteria Isolated from the gastrointestinal tract of a wild boar as potential probiotics. Frontiers in Veterinary Science 7:49. doi: 10.3389/fvets.2020.00049.
   PubMed Web of Science ®Google Scholar
• Li, Y., X. Wang, X. Q. Wang, J. Wang, and J. Zhao. 2020. Life-long dynamics of the swine gut microbiome and their implications in probiotics development and food safety. Gut Microbes 11 (6):1824–32. doi: 10.1080/19490976.2020.1773748.
   PubMed Web of Science ®Google Scholar
• Liang, S., D. Gao, H. Liu, C. Wang, and J. Wen. 2018. Metabolomic and proteomic analysis of D-lactate-producing Lactobacillus delbrueckii under various fermentation conditions. Journal of Industrial Microbiology & Biotechnology 45 (8):681–96. doi: 10.1007/s10295-018-2048-y.
   PubMedGoogle Scholar
• Liao, P. L., C. C. Wu, T. Y. Chen, Y. C. Tsai, W. S. Peng, D. J. Yang, and J. J. Kang. 2019. Toxicity studies of Lactobacillus plantarum PS128TM isolated from spontaneously fermented mustard greens. Foods 8 (12):668. doi: 10.3390/foods8120668.
   PubMedGoogle Scholar
• Lin, Y. C., Y. T. Chen, and M. J. Chen. 2018. Lack of mutagenicity, genotoxicity and developmental toxicity in safety assessment tests of Lactobacillus mali APS1. Plos ONE 13 (12):e0208881. doi: 10.1371/journal.pone.0208881.
   PubMedGoogle Scholar
• Liong, M. T. 2008. Safety of probiotics: Translocation and infection. Nutrition Reviews 66 (4):192–202. doi: 10.1111/j.1753-4887.2008.00024.x.
   PubMed Web of Science ®Google Scholar
• Liu, J., Y. Wang, A. Li, M. Iqbal, L. Zhang, H. Pan, Z. Liu, and J. Li. 2020. Probiotic potential and safety assessment of Lactobacillus isolated from yaks. Microbial Pathogenesis 145:104213. doi: 10.1016/j.micpath.2020.104213.
   PubMedGoogle Scholar
• Lorencová, E., L. Buňková, D. Matoulková, V. Dráb, P. Pleva, V. Kubáň, and F. Buňka. 2012. Production of biogenic amines by lactic acid bacteria and bifidobacteria isolated from dairy products and beer. International Journal of Food Science & Technology 47 (10):2086–91. doi: 10.1111/j.1365-2621.2012.03074.x.
   Web of Science ®Google Scholar
• Lu, H., W. Zhao, W. H. Liu, T. Sun, H. Lou, T. Wei, W. L. Hung, and Q. Chen. 2021. Safety Evaluation of Bifidobacterium lactis BL-99 and Lacticaseibacillus paracasei K56 and ET-22 in vitro and in vivo. Frontiers in Microbiology 12:686541. doi: 10.3389/fmicb.2021.686541.
   PubMed Web of Science ®Google Scholar
• Machado, D., J. C. Barbosa, D. Almeida, J. C. Andrade, A. C. Freitas, and A. M. Gomes. 2022b. Insights into the antimicrobial resistance profile of a next generation probiotic Akkermansia muciniphila DSM 22959. International Journal of Environmental Research and Public Health 19 (15):9152. doi: 10.3390/ijerph19159152.
   PubMedGoogle Scholar
• Machado, D., J. C. Barbosa, M. Domingos, D. Almeida, J. C. Andrade, A. C. Freitas, and A. M. Gomes. 2022a. Revealing antimicrobial resistance profile of the novel probiotic candidate Faecalibacterium prausnitzii DSM 17677. International Journal of Food Microbiology 363:109501. doi: 10.1016/j.ijfoodmicro.2021.109501.
   PubMedGoogle Scholar
• Mackowiak, P. A. 2013. Recycling Metchnikoff: Probiotics, the intestinal microbiome and the quest for long life. Frontiers in Public Health 1:52. doi: 10.3389/fpubh.2013.00052.
   PubMedGoogle Scholar
• Mann, S., M. S. Park, T. V. Johnston, G. E. Ji, K. T. Hwang, and S. Ku. 2021a. Isolation, characterization and biosafety evaluation of Lactobacillus fermentum OK with potential oral probiotic properties. Probiotics and Antimicrobial Proteins 13 (5):1363–86. doi: 10.1007/s12602-021-09761-z.
   PubMedGoogle Scholar
• Mann, S., M. S. Park, T. V. Johnston, G. E. Ji, K. T. Hwang, and S. Ku. 2021b. Oral probiotic activities and biosafety of Lactobacillus gasseri HHuMIN D. Microbial Cell Factories 20 (1):24. doi: 10.1186/s12934-021-01563-w.
   PubMedGoogle Scholar
• Mayo, B., C. T. Rachid, A. Alegría, A. M. Leite, R. S. Peixoto, and S. Delgado. 2014. Impact of next generation sequencing techniques in food microbiology. Current Genomics 15 (4):293–309. doi: 10.2174/1389202915666140616233211.
   PubMed Web of Science ®Google Scholar
• McArthur, A. G., N. Waglechner, F. Nizam, A. Yan, M. A. Azad, A. J. Baylay, K. Bhullar, M. J. Canova, G. De Pascale, L. Ejim, et al. 2013. The comprehensive antibiotic resistance database. Antimicrobial Agents and Chemotherapy 57 (7):3348–57. doi: 10.1128/AAC.00419-13.
   PubMed Web of Science ®Google Scholar
• Meini, S., R. Laureano, L. Fani, C. Tascini, A. Galano, A. Antonelli, and G. M. Rossolini. 2015. Breakthrough Lactobacillus rhamnosus GG bacteremia associated with probiotic use in an adult patient with severe active ulcerative colitis: Case report and review of the literature. Infection 43 (6):777–81. doi: 10.1007/s15010-015-0798-2.
   PubMed Web of Science ®Google Scholar
• Meleh, H. U., S. Choo, M. N. M. Desa, S. Y. Chew, P. Rangasamy, H. Hassan, and L. T. L. Than. 2020. Isolation and safety characterisation of lactobacilli strains with antimicrobial properties as potential probiotics for human use. LWT 131:109796. doi: 10.1016/j.lwt.2020.109796.
   Google Scholar
• Mendoza, R. M., S. H. Kim, R. Vasquez, I. C. Hwang, Y. S. Park, H. D. Paik, G. S. Moon, and D. K. Kang. 2023. Bioinformatics and its role in the study of the evolution and probiotic potential of lactic acid bacteria. Food Science and Biotechnology 32 (4):389–412. doi: 10.1007/s10068-022-01142-8.
   PubMedGoogle Scholar
• Miljkovic, M., S. Jovanovic, P. M. O’Connor, N. Mirkovic, B. Jovcic, B. Filipic, M. Dinic, D. J. Studholme, D. Fira, P. D. Cotter, et al. 2019. Brevibacillus laterosporus strains BGSP7, BGSP9 and BGSP11 isolated from silage produce broad spectrum multi-antimicrobials. Plos ONE 14 (5):e0216773. doi: 10.1371/journal.pone.0216773.
   PubMed Web of Science ®Google Scholar
• Morovic, W., J. M. Roper, A. B. Smith, P. Mukerji, B. Stahl, J. C. Rae, and A. C. Ouwehand. 2017. Safety evaluation of HOWARU® Restore (Lactobacillus acidophilus NCFM, Lactobacillus paracasei Lpc-37, Bifidobacterium animalis subsp. lactis Bl-04 and B. lactis Bi-07) for antibiotic resistance, genomic risk factors, and acute toxicity. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 110:316–24. doi: 10.1016/j.fct.2017.10.037.
   PubMed Web of Science ®Google Scholar
• Muñoz, M., N. Benomar, S. Ennahar, P. Horvatovich, L. L. Lerma, C. W. Knapp, A. Gálvez, and H. Abriouel. 2016. Comparative proteomic analysis of a potentially probiotic Lactobacillus pentosus MP-10 for the identification of key proteins involved in antibiotic resistance and biocide tolerance. International Journal of Food Microbiology 222:8–15. doi: 10.1016/j.ijfoodmicro.2016.01.012.
   PubMedGoogle Scholar
• Nagpal, R., and H. Yadav. 2017. Bacterial translocation from the gut to the distant organs: An overview. Annals of Nutrition and Metabolism 71 (Suppl. 1):11–6. doi: 10.1159/000479918.
   PubMedGoogle Scholar
• Naqvi, S. S. B., V. Nagendra, and A. Hofmeyr. 2018. Probiotic related Lactobacillus rhamnosus endocarditis in a patient with liver cirrhosis. IDCases 13:e00439. doi: 10.1016/j.idcr.2018.e00439.
   PubMed Web of Science ®Google Scholar
• Nawaz, M., J. Wang, A. Zhou, C. Ma, X. Wu, J. E. Moore, B. C. Millar, and J. Xu. 2011. Characterization and transfer of antibiotic resistance in lactic acid bacteria from fermented food products. Current Microbiology 62 (3):1081–9. doi: 10.1007/s00284-010-9856-2.
   PubMed Web of Science ®Google Scholar
• Nicoloff, H., V. Perreten, and S. B. Levy. 2007. Increased genome instability in Escherichia coli lon mutants: Relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. Antimicrobial Agents and Chemotherapy 51 (4):1293–303. doi: 10.1128/AAC.01128-06.
   PubMed Web of Science ®Google Scholar
• Nithya, V., S. P. Muthukumar, and P. M. Halami. 2012. Safety assessment of Bacillus licheniformis Me1 isolated from milk for probiotic application. International Journal of Toxicology 31 (3):228–37. doi: 10.1177/1091581812443388.
   PubMedGoogle Scholar
• O’Toole, P. W., J. R. Marchesi, and C. Hill. 2017. Next-generation probiotics: The spectrum from probiotics to live biotherapeutics. Nature Microbiology 2 (5):1–6. doi: 10.1038/nmicrobiol.2017.57.
   Google Scholar
• Ocvirk, S., and S. J. O’Keefe. 2017. Influence of bile acids on colorectal cancer risk: Potential mechanisms mediated by diet-gut microbiota interactions. Current Nutrition Reports 6 (4):315–22. doi: 10.1007/s13668-017-0219-5.
   PubMedGoogle Scholar
• OECD. 1995. Organization for economic cooperation and development: OECD guidelines for the testing of chemicals. Test guideline 408. Repeated dose 90-day oral toxicity study in rodent. OECD, Paris.
   Google Scholar
• OECD. 2008a. Organization for economic cooperation and development: OECD guidelines for the testing of chemicals. Test guideline 425. Acute oral toxicity-up-and-down procedure. OECD, Paris.
   Google Scholar
• OECD. 2008b. Organization for economic cooperation and development: OECD guidelines for the testing of chemicals. Test guideline 407. Repeated dose 28-day oral toxicity study in rodents. OECD, Paris.
   Google Scholar
• OECD. 2016a. Organization for economic cooperation and development: OECD guidelines for the testing of chemicals. Test guideline 474. In vivo mammalian erythrocyte micronucleus test. OCED, Paris.
   Google Scholar
• OECD. 2016b. Organization for economic cooperation and development: OECD guidelines for the testing of chemicals. Test guideline 489. In vivo mammalian alkaline comet assay. OCED, Paris.
   Google Scholar
• OECD. 2018a. Organization for economic cooperation and development: OECD guidelines for the testing of chemicals. Test guideline 452. Chronic toxicity studies. OECD, Paris.
   Google Scholar
• OECD. 2018b. Organization for economic cooperation and development: OECD guidelines for the testing of chemicals. Test guideline 414. Prenatal developmental toxicity study. OECD, Paris.
   Google Scholar
• Oh, Y. J., S. A. Kim, S. H. Yang, D. H. Kim, Y. Y. Cheng, J. I. Kang, S. Y. Lee, and N. S. Han. 2022. Integrated genome-based assessment of safety and probiotic characteristics of Lactiplantibacillus plantarum PMO 08 isolated from kimchi. Plos ONE 17 (10):e0273986. doi: 10.1371/journal.pone.0273986.
   PubMedGoogle Scholar
• Osman, A., M. Taipale, M. Najjar, and B. Osman. 2019. Lactobacillus paracasei endocarditis of bioprosthetic aortic valve presenting with recurrent embolic strokes. Access Microbiology 1 (8):000038. doi: 10.1099/acmi.0.000038.
   Google Scholar
• O’sullivan, D. J., and T. R. Klaenhammer. 1993. Rapid mini-prep isolation of high-quality plasmid DNA from Lactococcus and Lactobacillus spp. Applied and Environmental Microbiology 59 (8):2730–3. doi: 10.1128/aem.59.8.2730-2733.1993.
   PubMed Web of Science ®Google Scholar
• Özkan, E. R., T. Demirci, and N. Akın. 2021. In vitro assessment of probiotic and virulence potential of Enterococcus faecium strains derived from artisanal goatskin casing Tulum cheeses produced in central Taurus Mountains of Turkey. LWT 141:110908. doi: 10.1016/j.lwt.2021.110908.
   Web of Science ®Google Scholar
• Panthee, S., A. Paudel, H. Hamamoto, A. A. Ogasawara, T. Iwasa, J. Blom, and K. Sekimizu. 2021. Complete genome sequence and comparative genomic analysis of Enterococcus faecalis EF-2001, a probiotic bacterium. Genomics 113 (3):1534–42. doi: 10.1016/j.ygeno.2021.03.021.
   PubMedGoogle Scholar
• Paone, P., and P. D. Cani. 2020. Mucus barrier, mucins and gut microbiota: The expected slimy partners? Gut 69 (12):2232–43. doi: 10.1136/gutjnl-2020-322260.
   PubMed Web of Science ®Google Scholar
• Pasala, S., L. Singer, T. Arshad, and K. Roach. 2020. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases 22:e00915. doi: 10.1016/j.idcr.2020.e00915.
   PubMedGoogle Scholar
• Pepoyan, A. Z., M. H. Balayan, L. Malkhasyan, A. Manvelyan, T. Bezhanyan, R. Paronikyan, V. V. Tsaturyan, S. Tatikyan, S. Kamiya, and M. L. Chikindas. 2019. Effects of probiotic Lactobacillus acidophilus strain INMIA 9602 Er 317/402 and putative probiotic lactobacilli on DNA damages in the small intestine of Wistar rats in vivo. Probiotics and Antimicrobial Proteins 11 (3):905–9. doi: 10.1007/s12602-018-9491-y.
   PubMedGoogle Scholar
• Perreten, V., L. Vorlet-Fawer, P. Slickers, R. Ehricht, P. Kuhnert, and J. Frey. 2005. Microarray-based detection of 90 antibiotic resistance genes of gram-positive bacteria. Journal of Clinical Microbiology 43 (5):2291–302. doi: 10.1128/JCM.43.5.2291-2302.2005.
   PubMed Web of Science ®Google Scholar
• Pervez, M. T., Hasnain, M. J. U. Abbas, S. H. Moustafa, M. F. Aslam, N. Shah, and S. S. M. 2022. A comprehensive review of performance of next-generation sequencing platforms. BioMed Research International 2022:3457806. doi: 10.1155/2022/3457806.
   PubMedGoogle Scholar
• Poloni, V. L., M. B. Bainotti, L. D. Vergara, F. Escobar, M. Montenegro, and L. Cavaglieri. 2021. Influence of technological procedures on viability, probiotic and anti-mycotoxin properties of Saccharomyces boulardii RC009, and biological safety studies. Current Research in Food Science 4:132–40. doi: 10.1016/j.crfs.2021.02.006.
   PubMedGoogle Scholar
• Pradhan, D., R. Singh, A. Tyagi, H. M. Rashmi, V. K. Batish, and S. Grover. 2019a. Assessing safety of Lactobacillus plantarum MTCC 5690 and Lactobacillus fermentum MTCC 5689 using in vitro approaches and an in vivo murine model. Regulatory Toxicology and Pharmacology : RTP 101:1–11. doi: 10.1016/j.yrtph.2018.10.011.
   PubMed Web of Science ®Google Scholar
• Pradhan, D., R. Singh, A. Tyagi, H. M. Rashmi, V. K. Batish, and S. Grover. 2019b. Assessing the safety and efficacy of Lactobacillus plantarum MTCC 5690 and Lactobacillus fermentum MTCC 5689 in colitis mouse model. Probiotics and Antimicrobial Proteins 11 (3):910–20. doi: 10.1007/s12602-018-9489-5.
   PubMedGoogle Scholar
• Praveschotinunt, P., A. M. Duraj-Thatte, I. Gelfat, F. Bahl, D. B. Chou, and N. S. Joshi. 2019. Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut. Nature Communications 10 (1):5580. doi: 10.1038/s41467-019-13336-6.
   PubMedGoogle Scholar
• Prete, R., S. L. Long, A. L. Gallardo, C. G. Gahan, A. Corsetti, and S. A. Joyce. 2020. Beneficial bile acid metabolism from Lactobacillus plantarum of food origin. Scientific Reports 10 (1):11. doi: 10.1038/s41598-020-58069-5.
   PubMedGoogle Scholar
• Prieto, M. L., L. O’Sullivan, S. P. Tan, P. McLoughlin, H. Hughes, O. O’Donovan, M. C. Rea, R. M. Kent, J. P. Cassidy, G. E. Gardiner, et al. 2014. Evaluation of the efficacy and safety of a marine-derived Bacillus strain for use as an in-feed probiotic for newly weaned pigs. PLoS One 9 (2):e88599. doi: 10.1371/journal.pone.0088599.
   PubMed Web of Science ®Google Scholar
• Priyanka, V., A. Ramesha, D. Gayathri, and M. Vasudha. 2021. Molecular characterization of non-biogenic amines producing Lactobacillus plantarum GP11 isolated from traditional pickles using HRESI-MS analysis. Journal of Food Science and Technology 58 (6):2216–26. doi: 10.1007/s13197-020-04732-8.
   PubMedGoogle Scholar
• Qureshi, N., Q. Gu, and P. Li. 2020. Whole genome sequence analysis and in vitro probiotic characteristics of a Lactobacillus strain Lactobacillus paracasei ZFM54. Journal of Applied Microbiology 129 (2):422–33. doi: 10.1111/jam.14627.
   PubMedGoogle Scholar
• Rao, S. S., A. Rehman, S. Yu, and N. M. De Andino. 2018. Brain fogginess, gas and bloating: A link between SIBO, probiotics and metabolic acidosis. Clinical and Translational Gastroenterology 9 (6):162. doi: 10.1038/s41424-018-0030-7.
   PubMedGoogle Scholar
• Rastogi, S., V. Mittal, and A. Singh. 2020. In vitro evaluation of probiotic potential and safety assessment of Lactobacillus mucosae strains isolated from Donkey’s lactation. Probiotics and Antimicrobial Proteins 12 (3):1045–56. doi: 10.1007/s12602-019-09610-0.
   PubMedGoogle Scholar
• Razafindralambo, H., V. Correani, S. Fiorucci, and B. Mattei. 2020. Variability in probiotic formulations revealed by proteomics and physico-chemistry approach in relation to the gut permeability. Probiotics and Antimicrobial Proteins 12 (3):1193–202. doi: 10.1007/s12602-019-09590-1.
   PubMedGoogle Scholar
• Razavi, M., E. Kristiansson, C. F. Flach, and D. J. Larsson. 2020. The association between insertion sequences and antibiotic resistance genes. Msphere 5 (5):00418–20. doi: 10.1128/mSphere.00418-20.
   Google Scholar
• Riquelme, A. J., M. A. Calvo, A. M. Guzmán, M. S. Depix, P. García, C. Pérez, M. Arrese, and J. A. Labarca. 2003. Saccharomyces cerevisiae fungemia after Saccharomyces boulardii treatment in immunocompromised patients. Journal of Clinical Gastroenterology 36 (1):41–3. doi: 10.1097/00004836-200301000-00013.
   PubMed Web of Science ®Google Scholar
• Rodrigo-Torres, L., J. M. Landete, P. Huedo, Á. Peirotén, S. Langa, E. Rodríguez-Minguez, M. Medina, D. R. Arahal, R. Aznar, and J. L. Arqués. 2022. Complete genome sequences of Lacticaseibacillus paracasei INIA P272 (CECT 8315) and Lacticaseibacillus rhamnosus INIA P344 (CECT 8316) isolated from breast-fed infants reveal probiotic determinants. Gene 840:146743. doi: 10.1016/j.gene.2022.146743.
   PubMedGoogle Scholar
• Rodríguez-Nogales, A., F. Algieri, J. Garrido-Mesa, T. Vezza, M. P. Utrilla, N. Chueca, J. A. Fernández-Caballero, F. García, M. E. Rodríguez-Cabezas, and J. Gálvez. 2018. The administration of Escherichia coli Nissle 1917 ameliorates development of DSS-induced colitis in mice. Frontiers in Pharmacology 9:468. doi: 10.3389/fphar.2018.00468.
   PubMed Web of Science ®Google Scholar
• Rokana, N., R. H. Mallappa, V. K. Batish, and S. Grover. 2017. Interaction between putative probiotic Lactobacillus strains of Indian gut origin and Salmonella: Impact on intestinal barrier function. LWT-Food Science and Technology 84:851–60. doi: 10.1016/j.lwt.2016.08.021.
   Web of Science ®Google Scholar
• Romero, M. 2020. Detection of extracellular nuclease activity during lag and exponential growth phases of Lactobacillus Casei. Acta Microscopica 29:2051–6.
   Google Scholar
• Rose, E. C., A. T. Blikslager, and A. L. Ziegler. 2022. Porcine models of the intestinal microbiota: The translational key to understanding how gut commensals contribute to gastrointestinal disease. Frontiers in Veterinary Science 9:1–8. doi: 10.3389/fvets.2022.834598.
   Google Scholar
• Ruas-Madiedo, P., M. Gueimonde, M. Fernández-García, C. G. de los Reyes-Gavilán, and A. Margolles. 2008. Mucin degradation by Bifidobacterium strains isolated from the human intestinal microbiota. Applied and Environmental Microbiology 74 (6):1936–40. doi: 10.1128/AEM.02509-07.
   PubMedGoogle Scholar
• Rzepkowska, A., D. Zielińska, A. Ołdak, and D. Kołożyn-Krajewska. 2017. Safety assessment and antimicrobial properties of the lactic acid bacteria strains isolated from polish raw fermented meat products. International Journal of Food Properties 20 (11):2736–47. doi: 10.1080/10942912.2016.1250098.
   Web of Science ®Google Scholar
• Saarela, M. H. 2019. Safety aspects of next generation probiotics. Current Opinion in Food Science 30:8–13. doi: 10.1016/j.cofs.2018.09.001.
   Web of Science ®Google Scholar
• Saleh, I. D., H. H. Zain, I. Husni, N. D. Salih, and H. Gopalan. 2017. A locally synthesized probiotic for maintaining immune system functions in immunocompromised NZW rabbits. World Journal of Pharmacy and Pharmaceutical Sciences 6:111–24. doi: 10.20959/wjpps20176-9286.
   Google Scholar
• Salvetti, E., L. Orrù, V. Capozzi, A. Martina, A. Lamontanara, D. Keller, H. Cash, G. E. Felis, L. Cattivelli, S. Torriani, et al. 2016. Integrate genome-based assessment of safety for probiotic strains: Bacillus coagulans GBI-30, 6086 as a case study. Applied Microbiology and Biotechnology 100 (10):4595–605. doi: 10.1007/s00253-016-7416-9.
   PubMed Web of Science ®Google Scholar
• Samtiya, M., M. I. Bhat, T. Gupta, S. Kapila, and R. Kapila. 2020. Safety assessment of potential probiotic Lactobacillus fermentum MTCC-5898 in murine model after repetitive dose for 28 days (Sub-Acute Exposure). Probiotics and Antimicrobial Proteins 12 (1):259–70. doi: 10.1007/s12602-019-09529-6.
   PubMedGoogle Scholar
• Santino, I., A. Alari, S. Bono, E. Teti, M. Marangi, A. Bernardini, L. Magrini, S. Di Somma, and A. Teggi. 2014. Saccharomyces cerevisiae fungemia, a possible consequence of the treatment of Clostridium difficile colitis with a probioticum. International Journal of Immunopathology and Pharmacology 27 (1):143–6. doi: 10.1177/039463201402700120.
   PubMedGoogle Scholar
• Saroj, D. B., and A. K. Gupta. 2020. Genome based safety assessment for Bacillus coagulans strain LBSC (DSM 17654) for probiotic application. International Journal of Food Microbiology 318:108523. doi: 10.1016/j.ijfoodmicro.2020.108523.
   PubMed Web of Science ®Google Scholar
• Senan, S., J. B. Prajapati, and C. G. Joshi. 2015. Feasibility of genome-wide screening for biosafety assessment of probiotics: A case study of Lactobacillus helveticus MTCC 5463. Probiotics and Antimicrobial Proteins 7 (4):249–58. doi: 10.1007/s12602-015-9199-1.
   PubMed Web of Science ®Google Scholar
• Sharma, A., S. Lee, and Y. S. Park. 2020. Molecular typing tools for identifying and characterizing lactic acid bacteria: A review. Food Science and Biotechnology 29 (10):1301–18. doi: 10.1007/s10068-020-00802-x.
   PubMedGoogle Scholar
• Sherid, M., S. Samo, S. Sulaiman, H. Husein, H. Sifuentes, and S. Sridhar. 2016. Liver abscess and bacteremia caused by lactobacillus: Role of probiotics? Case report and review of the literature. BMC Gastroenterology 16 (1):138. doi: 10.1186/s12876-016-0552-y.
   PubMedGoogle Scholar
• Shimura, M., M. Mizuma, K. Nakagawa, S. Aoki, T. Miura, T. Takadate, K. Ariake, S. Maeda, K. Kawaguchi, K. Masuda, et al. 2021. Probiotic-related bacteremia after major hepatectomy for biliary cancer: A report of two cases. Surgical Case Reports 7 (1):8. doi: 10.1186/s40792-021-01216-5.
   PubMedGoogle Scholar
• Shin, J., J.-R. Noh, D.-H. Chang, Y.-H. Kim, M. H. Kim, E. S. Lee, S. Cho, B. J. Ku, M.-S. Rhee, B.-C. Kim, et al. 2019. Elucidation of Akkermansia muciniphila probiotic traits driven by mucin depletion. Frontiers in Microbiology 10:1137. doi: 10.3389/fmicb.2019.01137.
   PubMed Web of Science ®Google Scholar
• Shokryazdan, P., M. Faseleh Jahromi, J. B. Liang, R. Kalavathy, C. C. Sieo, and Y. W. Ho. 2016. Safety assessment of two new Lactobacillus strains as probiotic for human using a rat model. Plos ONE 11 (7):e0159851. doi: 10.1371/journal.pone.0159851.
   PubMed Web of Science ®Google Scholar
• Simon, O. 2010. An interdisciplinary study on the mode of action of probiotics in pigs. Journal of Animal and Feed Sciences 19 (2):230–43. doi: 10.22358/jafs/66284/2010.
   Google Scholar
• Sirichoat, A., A. B. Flórez, L. Vázquez, P. Buppasiri, M. Panya, V. Lulitanond, and B. Mayo. 2020. Antibiotic susceptibility profiles of lactic acid bacteria from the human vagina and genetic basis of acquired resistances. International Journal of Molecular Sciences 21 (7):2594. doi: 10.3390/ijms21072594.
   PubMed Web of Science ®Google Scholar
• Skvortsov, E., R. Mukhammadiev, R. Mukhammadiev, L. Valiullin, and V. Rud. 2021. Study of the reproductive toxicity of probiotic strains on laboratory animals. In IOP Conference Series: Earth and Environmental Science, vol. 663, 012034. IOP Publishing. doi: 10.1088/1755-1315/663/1/012034.
   Google Scholar
• Soltani, S., R. Hammami, P. D. Cotter, S. Rebuffat, L. B. Said, H. Gaudreau, F. Bédard, E. Biron, D. Drider, and I. Fliss. 2021. Bacteriocins as a new generation of antimicrobials: Toxicity aspects and regulations. FEMS Microbiology Reviews 45 (1):fuaa039. doi: 10.1093/femsre/fuaa039.
   PubMed Web of Science ®Google Scholar
• Son, S. H., H. L. Jeon, S. J. Yang, M. H. Sim, Y. J. Kim, N. K. Lee, and H. D. Paik. 2018. Probiotic lactic acid bacteria isolated from traditional Korean fermented foods based on β-glucosidase activity. Food Science and Biotechnology 27 (1):123–9. doi: 10.1007/s10068-017-0212-1.
   PubMed Web of Science ®Google Scholar
• Sonpal, N., R. Tsai, J. Vinod, M. Satchi, D. Vadada, and A. Chun. 2010. Saccharomyces cerevisiae gungemia after Saccharomyces boulardii treatment in an immunocompetent patient: 954. American Journal of Gastroenterology 105:S345. doi: 10.14309/00000434-201010001-00954.
   PubMedGoogle Scholar
• Sornsenee, P., K. Singkhamanan, S. Sangkhathat, P. Saengsuwan, and C. Romyasamit. 2021. Probiotic properties of Lactobacillus species isolated from fermented palm sap in Thailand. Probiotics and Antimicrobial Proteins 13 (4):957–69. doi: 10.1007/s12602-021-09754-y.
   PubMedGoogle Scholar
• Sotoudegan, F., M. Daniali, S. Hassani, S. Nikfar, and M. Abdollahi. 2019. Reappraisal of probiotics’ safety in human. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 129:22–9. doi: 10.1016/j.fct.2019.04.032.
   PubMed Web of Science ®Google Scholar
• Steppe, M., F. Van Nieuwerburgh, G. Vercauteren, F. Boyen, V. Eeckhaut, D. Deforce, F. Haesebrouck, R. Ducatelle, and F. Van Immerseel. 2014. Safety assessment of the butyrate-producing Butyricicoccus pullicaecorum strain 25-3T, a potential probiotic for patients with inflammatory bowel disease, based on oral toxicity tests and whole genome sequencing. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 72:129–37. doi: 10.1016/j.fct.2014.06.024.
   PubMedGoogle Scholar
• Su, G. L., C. W. Ko, P. Bercik, Y. Falck-Ytter, S. Sultan, A. V. Weizman, and R. L. Morgan. 2020. AGA clinical practice guidelines on the role of probiotics in the management of gastrointestinal disorders. Gastroenterology 159 (2):697–705. doi: 10.1053/j.gastro.2020.05.059.
   PubMed Web of Science ®Google Scholar
• Sun, Y., H. Li, L. Zheng, J. Li, Y. Hong, P. Liang, L. Y. Kwok, Y. Zuo, W. Zhang, and H. Zhang. 2022. iProbiotics: A machine learning platform for rapid identification of probiotic properties from whole-genome primary sequences. Briefings in Bioinformatics 23 (1):477. doi: 10.1093/bib/bbab477.
   Google Scholar
• Tan, H., C. Wang, Q. Zhang, X. Tang, J. Zhao, H. Zhang, Q. Zhai, and W. Chen. 2020. Preliminary safety assessment of a new Bacteroides fragilis isolate. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 135:110934. doi: 10.1016/j.fct.2019.110934.
   PubMed Web of Science ®Google Scholar
• Tan, H., Z. Yu, C. Wang, Q. Zhang, J. Zhao, H. Zhang, Q. Zhai, and W. Chen. 2018. Pilot safety evaluation of a novel strain of Bacteroides ovatus. Frontiers in Genetics 9:539. doi: 10.3389/fgene.2018.00539.
   PubMedGoogle Scholar
• Tang, L., S. Song, C. Hu, J. C. W. Lam, M. Liu, B. Zhou, P. K. Lam, and L. Chen. 2020. Unexpected observations: Probiotic administration greatly aggravates the reproductive toxicity of perfluorobutanesulfonate in zebrafish. Chemical Research in Toxicology 33 (7):1605–8. doi: 10.1021/acs.chemrestox.0c00139.
   PubMedGoogle Scholar
• Tarrah, A., S. Pakroo, V. Corich, and A. Giacomini. 2021. Identification and transferability of tetracycline resistance in Streptococcus thermophilus during milk fermentation, storage, and gastrointestinal transit. Fermentation 7 (2):65. doi: 10.3390/fermentation7020065.
   Google Scholar
• Terai, T., K. Kato, E. Ishikawa, M. Nakao, M. Ito, K. Miyazaki, A. Kushiro, S. Imai, Y. Nomura, N. Hanada, et al. 2020. Safety assessment of the candidate oral probiotic Lactobacillus crispatus YIT 12319: Analysis of antibiotic resistance and virulence-associated genes. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 140:111278. doi: 10.1016/j.fct.2020.111278.
   PubMed Web of Science ®Google Scholar
• Thomas, D. J., R. J. Husmann, M. Villamar, T. R. Winship, R. H. Buck, and F. A. Zuckermann. 2011. Lactobacillus rhamnosus HN001 attenuates allergy development in a pig model. PLoS One. 6 (2):e16577. doi: 10.1371/journal.pone.0016577.
   PubMedGoogle Scholar
• Thumu, S. C. R., and P. M. Halami. 2020. In vivo safety assessment of Lactobacillus fermentum strains, evaluation of their cholesterol‐lowering ability and intestinal microbial modulation. Journal of the Science of Food and Agriculture 100 (2):705–13. doi: 10.1002/jsfa.10071.
   PubMedGoogle Scholar
• Thygesen, J. B., H. Glerup, and B. Tarp. 2012. Saccharomyces boulardii fungemia caused by treatment with a probioticum. Case Reports 2012 (1):bcr0620114412. doi: 10.1136/bcr.06.2011.4412.
   PubMedGoogle Scholar
• Todorov, S. D., S. Stojanovski, I. Iliev, P. Moncheva, L. A. Nero, and I. V. Ivanova. 2017. Technology and safety assessment for lactic acid bacteria isolated from traditional Bulgarian fermented meat product" lukanka. Brazilian Journal of Microbiology : [Publication of the Brazilian Society for Microbiology] 48 (3):576–86. doi: 10.1016/j.bjm.2017.02.005.
   PubMed Web of Science ®Google Scholar
• Tofalo, R., G. Perpetuini, M. Schirone, and G. Suzzi. 2016. Biogenic amines: Toxicology and health effect. UK: Elsevier
   Google Scholar
• Toomey, N., Á. Monaghan, S. Fanning, and D. J. Bolton. 2009. Assessment of horizontal gene transfer in lactic acid bacteria–a comparison of mating techniques with a view to optimising conjugation conditions. Journal of Microbiological Methods 77 (1):23–8. doi: 10.1016/j.mimet.2008.12.002.
   PubMed Web of Science ®Google Scholar
• Toropov, V., E. Demyanova, O. Shalaeva, S. Sitkin, and T. Vakhitov. 2020. Whole-genome sequencing of Lactobacillus helveticus D75 and D76 confirms safety and probiotic potential. Microorganisms 8 (3):329. doi: 10.3390/microorganisms8030329.
   PubMed Web of Science ®Google Scholar
• Trapecar, M., T. Leouffre, M. Faure, H. E. Jensen, P. E. Granum, A. Cencic, and S. P. Hardy. 2011. The use of a porcine intestinal cell model system for evaluating the food safety risk of Bacillus cereus probiotics and the implications for assessing enterotoxigenicity. APMIS : Acta Pathologica, Microbiologica, et Immunologica Scandinavica 119 (12):877–84. doi: 10.1111/j.1600-0463.2011.02797.x.
   PubMedGoogle Scholar
• Tseng, W. T., T. W. Shih, S. H. Liu, and T. M. Pan. 2015. Safety and mutagenicity evaluation of Vigiis 101 powder made from Lactobacillus paracasei subsp. paracasei NTU 101. Regulatory Toxicology and Pharmacology : RTP 71 (2):148–57. doi: 10.1016/j.yrtph.2014.11.008.
   PubMedGoogle Scholar
• Ukelis, U., P. J. Kramer, K. Olejniczak, and S. O. Mueller. 2008. Replacement of in vivo acute oral toxicity studies by in vitro cytotoxicity methods: Opportunities, limits and regulatory status. Regulatory Toxicology and Pharmacology : RTP 51 (1):108–18. doi: 10.1016/j.yrtph.2008.02.002.
   PubMedGoogle Scholar
• Urshev, Z., and T. Yungareva. 2021. Initial safety evaluation of Enterococcus faecium LBB. E81. Biotechnology & Biotechnological Equipment 35 (1):11–7. doi: 10.1080/13102818.2020.1840438.
   Web of Science ®Google Scholar
• Vankerckhoven, V., G. Huys, M. Vancanneyt, C. Vael, I. Klare, M.-B. Romond, J. M. Entenza, P. Moreillon, R. D. Wind, J. Knol, et al. 2008. Biosafety assessment of probiotics used for human consumption: Recommendations from the EU-PROSAFE project. Trends in Food Science & Technology 19 (2):102–14. doi: 10.1016/j.tifs.2007.07.013.
   Google Scholar
• Vankerckhoven, V., P. Moreillon, S. Piu, M. Giddey, G. Huys, M. Vancanneyt, H. Goossens, and J. M. Entenza. 2007. Infectivity of Lactobacillus rhamnosus and Lactobacillus paracasei isolates in a rat model of experimental endocarditis. Journal of Medical Microbiology 56 (Pt 8):1017–24. doi: 10.1099/jmm.0.46929-0.
   PubMedGoogle Scholar
• Ventoulis, I., T. Sarmourli, P. Amoiridou, P. Mantzana, M. Exindari, G. Gioula, and T. A. Vyzantiadis. 2020. Bloodstream infection by Saccharomyces cerevisiae in two COVID-19 patients after receiving supplementation of Saccharomyces in the ICU. Journal of Fungi 6 (3):98. doi: 10.3390/jof6030098.
   Google Scholar
• Verma, A., and G. Shukla. 2013. Probiotics Lactobacillus rhamnosus GG, Lactobacillus acidophilus suppresses DMH-induced procarcinogenic fecal enzymes and preneoplastic aberrant crypt foci in early colon carcinogenesis in Sprague Dawley rats. Nutrition and Cancer 65 (1):84–91. doi: 10.1080/01635581.2013.741746.
   PubMed Web of Science ®Google Scholar
• Vesterlund, S., V. Vankerckhoven, M. Saxelin, H. Goossens, S. Salminen, and A. C. Ouwehand. 2007. Safety assessment of Lactobacillus strains: Presence of putative risk factors in faecal, blood and probiotic isolates. International Journal of Food Microbiology 116 (3):325–31. doi: 10.1016/j.ijfoodmicro.2007.02.002.
   PubMed Web of Science ®Google Scholar
• Vitetta, L., S. Coulson, M. Thomsen, T. Nguyen, and S. Hall. 2017. Probiotics, D-lactic acidosis, oxidative stress and strain specificity. Gut Microbes 8 (4):311–22. doi: 10.1080/19490976.2017.1279379.
   PubMed Web of Science ®Google Scholar
• Wang, J., R. Da, X. Tuo, Y. Cheng, J. Wei, K. Jiang, J. Lv, O. M. Adediji, and B. Han. 2020. Probiotic and safety properties screening of Enterococcus faecalis from healthy Chinese infants. Probiotics and Antimicrobial Proteins 12 (3):1115–25. doi: 10.1007/s12602-019-09625-7.
   PubMed Web of Science ®Google Scholar
• Wang, M., Z. Zeng, F. Jiang, Y. Zheng, H. Shen, N. Macedo, Y. Sun, O. Sahin, and G. Li. 2020. Role of enterotoxigenic Escherichia coli prophage in spreading antibiotic resistance in a porcine‐derived environment. Environmental Microbiology 22 (12):4974–84. doi: 10.1111/1462-2920.15084.
   PubMed Web of Science ®Google Scholar
• Wang, X., Y. Yang, and M. M. Huycke. 2020. Risks associated with enterococci as probiotics. Food Research International (Ottawa, Ont.) 129:108788. doi: 10.1016/j.foodres.2019.108788.
   PubMedGoogle Scholar
• Wang, Y., Q. Liang, B. Lu, H. Shen, S. Liu, Y. Shi, S. Leptihn, H. Li, J. Wei, C. Liu, et al. 2021. Whole-genome analysis of probiotic product isolates reveals the presence of genes related to antimicrobial resistance, virulence factors, and toxic metabolites, posing potential health risks. BMC Genomics 22 (1):12. doi: 10.1186/s12864-021-07539-9.
   PubMedGoogle Scholar
• Wassenaar, T. M. 2016. Insights from 100 years of research with probiotic E. coli. European Journal of Microbiology & Immunology 6 (3):147–61. doi: 10.1556/1886.2016.00029.
   PubMedGoogle Scholar
• Wen, K., C. Tin, H. Wang, X. Yang, G. Li, E. Giri-Rachman, J. Kocher, T. Bui, S. Clark-Deener, and L. Yuan. 2014. Probiotic Lactobacillus rhamnosus GG enhanced Th1 cellular immunity but did not affect antibody responses in a human gut microbiota transplanted neonatal gnotobiotic pig model. PLoS One 9 (4):e94504. doi: 10.1371/journal.pone.0094504.
   PubMed Web of Science ®Google Scholar
• Yang, C., and T. Yu. 2019. Characterization and transfer of antimicrobial resistance in lactic acid bacteria from fermented dairy products in China. Journal of Infection in Developing Countries 13 (2):137–48. doi: 10.3855/jidc.10765.
   PubMedGoogle Scholar
• Yasmin, I., M. Saeed, W. A. Khan, A. Khaliq, M. F. J. Chughtai, R. Iqbal, S. Tehseen, S. Naz, A. Liaqat, T. Mehmood, et al. 2020. In vitro probiotic potential and safety evaluation (hemolytic, cytotoxic Activity) of Bifidobacterium Strains isolated from raw camel milk. Microorganisms 8 (3):354. doi: 10.3390/microorganisms8030354.
   PubMedGoogle Scholar
• Yazdankhah, S. P., K. F. Eckner, R. Halvorsen, G. Kapperud, J. F. Lassen, J. Narvhus, T. Nesbakken, L. Robertson, J. T. Rosnes, T. Skjerdal, et al. 2014. Guidelines for assessment of safety aspects of probiotic (food) products. Opinion of the panel on Biological Hazards of the Norwegian Scientific Committee for Food Safety. Norway: VKM Report.
   Google Scholar
• Yetiman, A. E., A. Keskin, B. N. Darendeli, S. E. Kotil, F. Ortakci, and M. Dogan. 2022. Characterization of genomic, physiological, and probiotic features Lactiplantibacillus plantarum DY46 strain isolated from traditional lactic acid fermented shalgam beverage. Food Bioscience 46:101499. doi: 10.1016/j.fbio.2021.101499.
   Google Scholar
• Zeba, F., J. Yirerong, M. Assali, G. Tewary, and M. D. Amanda Noska. 2018. A double whammy: Lactobacillus acidophilus bacteremia and subsequent Lactobacillus rhamnosus prosthetic valve infective endocarditis in an elderly diabetic patient. Rhode Island Medical Journal 101:32–5.
   Google Scholar
• Zeng, Y., Y. Li, Q. P. Wu, J. M. Zhang, X. Q. Xie, Y. Ding, S. Z. Cai, Q. H. Ye, M. T. Chen, L. Xue, et al. 2020. Evaluation of the antibacterial activity and probiotic potential of Lactobacillus plantarum Isolated from Chinese homemade pickles. Canadian Journal of Infectious Diseases and Medical Microbiology 2020:1–11. doi: 10.1155/2020/8818989.
   Web of Science ®Google Scholar
• Zhang, B., B. Lynch, J. Zhao, Y. Guo, and A. Mak. 2021. Lactobacillus rhamnosus MP108: Toxicological evaluation. Journal of Food Science 86 (1):228–41. doi: 10.1111/1750-3841.15546.
   PubMedGoogle Scholar
• Zhang, F., M. Jiang, C. Wan, X. Chen, X. Chen, X. Tao, N. P. Shah, and H. Wei. 2016. Screening probiotic strains for safety: Evaluation of virulence and antimicrobial susceptibility of enterococci from healthy Chinese infants. Journal of Dairy Science 99 (6):4282–90. doi: 10.3168/jds.2015-10690.
   PubMed Web of Science ®Google Scholar
• Zielińska, D., B. Sionek, and D. Kołożyn-Krajewska. 2018. Safety of probiotics. In Diet, microbiome and health, ed. M. H. Alina and M. G. Alexandru, 131–61. UK: Academic Press.
   Google Scholar