The role of curcumin in the liver-gut system diseases: from mechanisms to clinical therapeutic perspective

References

• Adhvaryu, M. R., N. Reddy, and B. C. Vakharia. 2008. Prevention of hepatotoxicity due to anti tuberculosis treatment: A novel integrative approach. World Journal of Gastroenterology 14 (30):4753–62. doi: 10.3748/wjg.14.4753.
   PubMed Web of Science ®Google Scholar
• Albhaisi, S. A. M., J. S. Bajaj, and A. J. Sanyal. 2020. Role of gut microbiota in liver disease. American Journal of Physiology. Gastrointestinal and Liver Physiology 318 (1):G84–g98. doi: 10.1152/ajpgi.00118.2019.
   PubMed Web of Science ®Google Scholar
• Ali, S. O., H. A. Darwish, and N. A. Ismail. 2016. Curcumin, silybin Phytosome(®) and α-R-lipoic acid mitigate chronic hepatitis in rat by inhibiting oxidative stress and inflammatory cytokines production. Basic & Clinical Pharmacology & Toxicology 118 (5):369–80. doi: 10.1111/bcpt.12502.
   PubMed Web of Science ®Google Scholar
• Alli-Oluwafuyi, A. M., P. B. Luis, F. Nakashima, J. A. Giménez-Bastida, S. H. Presley, M. T. Duvernay, E. O. Iwalewa, and C. Schneider. 2019. Curcumin induces secretion of glucagon-like peptide-1 through an oxidation-dependent mechanism. Biochimie 165:250–7. doi: 10.1016/j.biochi.2019.08.013.
   PubMed Web of Science ®Google Scholar
• Anggakusuma, C. C. Colpitts, L. M. Schang, H. Rachmawati, A. Frentzen, S. Pfaender, P. Behrendt, R. J. P. Brown, D. Bankwitz, J. Steinmann, et al. 2014. Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Gut 63 (7):1137–49. doi: 10.1136/gutjnl-2012-304299.
   PubMed Web of Science ®Google Scholar
• Arab, J. P., R. M. Martin-Mateos, and V. H. Shah. 2018. Gut-liver axis, cirrhosis and portal hypertension: The chicken and the egg. Hepatology International 12 (Suppl 1):24–33. doi: 10.1007/s12072-017-9798-x.
   PubMedGoogle Scholar
• Aslanturk, A., and M. Uzunhisarcikli. 2020. Protective potential of curcumin or taurine on nephrotoxicity caused by bisphenol A. Environmental Science and Pollution Research International 27 (19):23994–4003. doi: 10.1007/s11356-020-08716-1.
   PubMed Web of Science ®Google Scholar
• Baghdasaryan, A., T. Claudel, A. Kosters, J. Gumhold, D. Silbert, A. Thüringer, K. Leski, P. Fickert, S. J. Karpen, and M. Trauner. 2010. Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation. Gut 59 (4):521–30. doi: 10.1136/gut.2009.186528.
   PubMed Web of Science ®Google Scholar
• Barta, A., P. Janega, P. Babál, E. Murár, M. Cebová, and O. Pechánová. 2015. The effect of curcumin on liver fibrosis in the rat model of microsurgical cholestasis. Food & Function 6 (7):2187–93. doi: 10.1039/c5fo00176e.
   PubMed Web of Science ®Google Scholar
• Bereswill, S., M. Muñoz, A. Fischer, R. Plickert, L. M. Haag, B. Otto, A. A. Kühl, C. Loddenkemper, U. B. Göbel, and M. M. Heimesaat. 2010. Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PloS One 5 (12):e15099. doi: 10.1371/journal.pone.0015099.
   PubMed Web of Science ®Google Scholar
• Bommelaer, G., D. Laharie, S. Nancey, X. Hebuterne, X. Roblin, M. Nachury, L. Peyrin-Biroulet, M. Fumery, D. Richard, B. Pereira, et al. 2020. Oral curcumin no more effective than placebo in preventing recurrence of Crohn’s disease after surgery in a randomized controlled trial. Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association 18 (7):1553–60.e1551. doi: 10.1016/j.cgh.2019.08.041.
   PubMed Web of Science ®Google Scholar
• Boursier, J., O. Mueller, M. Barret, M. Machado, L. Fizanne, F. Araujo-Perez, C. D. Guy, P. C. Seed, J. F. Rawls, L. A. David, et al. 2016. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology (Baltimore, Md.) 63 (3):764–75. doi: 10.1002/hep.28356.
   PubMed Web of Science ®Google Scholar
• Bulku, E., S. J. Stohs, L. Cicero, T. Brooks, H. Halley, and S. D. Ray. 2012. Curcumin exposure modulates multiple pro-apoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity. Current Neurovascular Research 9 (1):58–71. doi: 10.2174/156720212799297083.
   PubMed Web of Science ®Google Scholar
• Burapan, S., M. Kim, and J. Han. 2017. Curcuminoid demethylation as an alternative metabolism by human intestinal microbiota. Journal of Agricultural and Food Chemistry 65 (16):3305–10. doi: 10.1021/acs.jafc.7b00943.
   PubMed Web of Science ®Google Scholar
• Cao, J., Y. Liu, L. Jia, H. M. Zhou, Y. Kong, G. Yang, L. P. Jiang, Q. J. Li, and L. F. Zhong. 2007. Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cells. Free Radical Biology & Medicine 43 (6):968–75. doi: 10.1016/j.freeradbiomed.2007.06.006.
   PubMed Web of Science ®Google Scholar
• Cao, W., Y. Zhang, A. Li, P. Yu, L. Song, J. Liang, N. Cao, J. Gao, R. Xu, Y. Ma, et al. 2021. Curcumin reverses hepatic epithelial mesenchymal transition induced by trichloroethylene by inhibiting IL-6R/STAT3. Toxicology Mechanisms and Methods 31 (8):589–99. doi: 10.1080/15376516.2021.1941463.
   PubMed Web of Science ®Google Scholar
• Carpino, G., M. Del Ben, D. Pastori, R. Carnevale, F. Baratta, D. Overi, H. Francis, V. Cardinale, P. Onori, S. Safarikia, et al. 2020. Increased liver localization of lipopolysaccharides in human and experimental NAFLD. Hepatology (Baltimore, Md.) 72 (2):470–85. doi: 10.1002/hep.31056.
   PubMed Web of Science ®Google Scholar
• Castelló, A., P. Amiano, N. Fernández de Larrea, V. Martín, M. H. Alonso, G. Castaño-Vinyals, B. Pérez-Gómez, R. Olmedo-Requena, M. Guevara, G. Fernandez-Tardon, et al. 2019. Low adherence to the western and high adherence to the mediterranean dietary patterns could prevent colorectal cancer. European Journal of Nutrition 58 (4):1495–505. doi: 10.1007/s00394-018-1674-5.
   PubMed Web of Science ®Google Scholar
• Chen, A., and S. Zheng. 2008. Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling. British Journal of Pharmacology 153 (3):557–67. doi: 10.1038/sj.bjp.0707542.
   PubMed Web of Science ®Google Scholar
• Chen, M. H., M. Y. Lee, J. J. Chuang, Y. Z. Li, S. T. Ning, J. C. Chen, and Y. W. Liu. 2012. Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. International Journal of Molecular Medicine 30 (5):1021–8. doi: 10.3892/ijmm.2012.1096.
   PubMed Web of Science ®Google Scholar
• Chen, N., Q. Geng, J. Zheng, S. He, X. Huo, and X. Sun. 2014. Suppression of the TGF-β/Smad signaling pathway and inhibition of hepatic stellate cell proliferation play a role in the hepatoprotective effects of curcumin against alcohol-induced hepatic fibrosis. International Journal of Molecular Medicine 34 (4):1110–6. doi: 10.3892/ijmm.2014.1867.
   PubMed Web of Science ®Google Scholar
• Cheng, A. L., C. H. Hsu, J. K. Lin, M. M. Hsu, Y. F. Ho, T. S. Shen, J. Y. Ko, J. T. Lin, B. R. Lin, W. Ming-Shiang, et al. 2001. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Research 21 (4b):2895–900.
   PubMed Web of Science ®Google Scholar
• Choi, H., Y. S. Chun, S. W. Kim, M. S. Kim, and J. W. Park. 2006. Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: A mechanism of tumor growth inhibition. Molecular Pharmacology 70 (5):1664–71. doi: 10.1124/mol.106.025817.
   PubMed Web of Science ®Google Scholar
• Chuang, S. E., A. L. Cheng, J. K. Lin, and M. L. Kuo. 2000. Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 38 (11):991–5. doi: 10.1016/s0278-6915(00)00101-0.
   PubMed Web of Science ®Google Scholar
• Cicero, A. F. G., A. Sahebkar, F. Fogacci, M. Bove, M. Giovannini, and C. Borghi. 2020. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: A double-blind, placebo-controlled clinical trial. European Journal of Nutrition 59 (2):477–83. doi: 10.1007/s00394-019-01916-7.
   PubMed Web of Science ®Google Scholar
• Cobbina, E., and F. Akhlaghi. 2017. Non-alcoholic fatty liver disease (NAFLD) - pathogenesis, classification, and effect on drug metabolizing enzymes and transporters. Drug Metabolism Reviews 49 (2):197–211. doi: 10.1080/03602532.2017.1293683.
   PubMed Web of Science ®Google Scholar
• Compare, D., P. Coccoli, A. Rocco, O. M. Nardone, S. De Maria, M. Cartenì, and G. Nardone. 2012. Gut–liver axis: The impact of gut microbiota on non alcoholic fatty liver disease. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD 22 (6):471–6. doi: 10.1016/j.numecd.2012.02.007.
   PubMed Web of Science ®Google Scholar
• Cong, Y., L. Wang, A. Konrad, T. Schoeb, and C. O. Elson. 2009. Curcumin induces the tolerogenic dendritic cell that promotes differentiation of intestine-protective regulatory T cells. European Journal of Immunology 39 (11):3134–46. doi: 10.1002/eji.200939052.
   PubMed Web of Science ®Google Scholar
• Dash, R. P., M. Kala, M. Nivsarkar, and R. J. Babu. 2017. Implication of formulation strategies on the bioavailability of selected plant-derived hepatoprotectants. Critical Reviews in Therapeutic Drug Carrier Systems 34 (6):489–526. doi: 10.1615/CritRevTherDrugCarrierSyst.2017019623.
   PubMed Web of Science ®Google Scholar
• Deters, M., C. Siegers, W. Hänsel, K. P. Schneider, and G. Hennighausen. 2000. Influence of curcumin on cyclosporin-induced reduction of biliary bilirubin and cholesterol excretion and on biliary excretion of cyclosporin and its metabolites. Planta Medica 66 (5):429–34. doi: 10.1055/s-2000-8584.
   PubMed Web of Science ®Google Scholar
• Deters, M., C. Siegers, P. Muhl, and W. Hänsel. 1999. Choleretic effects of curcuminoids on an acute cyclosporin-induced cholestasis in the rat. Planta Medica 65 (7):610–3. doi: 10.1055/s-1999-14033.
   PubMed Web of Science ®Google Scholar
• Diamant, M., E. E. Blaak, and W. M. de Vos. 2011. Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes? Obesity Reviews: An Official Journal of the International Association for the Study of Obesity 12 (4):272–81. doi: 10.1111/j.1467-789X.2010.00797.x.
   PubMed Web of Science ®Google Scholar
• Dogaru, G., A. E. Bulboaca, D. Gheban, P. M. Boarescu, V. Rus, D. Festila, A. V. Sitar-Taut, and I. Stanescu. 2020. Effect of liposomal curcumin on acetaminophen hepatotoxicity by down-regulation of oxidative stress and matrix metalloproteinases. In Vivo (Athens, Greece) 34 (2):569–82. doi: 10.21873/invivo.11809.
   PubMed Web of Science ®Google Scholar
• Du, S., X. Zhu, N. Zhou, W. Zheng, W. Zhou, and X. Li. 2022. Curcumin alleviates hepatic steatosis by improving mitochondrial function in postnatal overfed rats and fatty L02 cells through the SIRT3 pathway. Food & Function 13 (4):2155–71. doi: 10.1039/d1fo03752h.
   PubMed Web of Science ®Google Scholar
• Eshaghian, A., A. Khodarahmi, F. Safari, F. Binesh, and A. Moradi. 2018. Curcumin attenuates hepatic fibrosis and insulin resistance induced by bile duct ligation in rats. The British Journal of Nutrition 120 (4):393–403. doi: 10.1017/S0007114518001095.
   PubMed Web of Science ®Google Scholar
• Farzaei, M., M. Zobeiri, F. Parvizi, F. El-Senduny, I. Marmouzi, E. Coy-Barrera, R. Naseri, S. Nabavi, R. Rahimi, and M. Abdollahi. 2018. Curcumin in liver diseases: A systematic review of the cellular mechanisms of oxidative stress and clinical perspective. Nutrients 10 (7):855. doi: 10.3390/nu10070855.
   PubMed Web of Science ®Google Scholar
• Feng, D., J. Zou, D. Su, H. Mai, S. Zhang, P. Li, and X. Zheng. 2019. Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE(-/-) mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-κB inflammation. Nutrition & Metabolism 16:79. doi: 10.1186/s12986-019-0410-3.
   PubMed Web of Science ®Google Scholar
• Feng, W., H. Wang, P. Zhang, C. Gao, J. Tao, Z. Ge, D. Zhu, and Y. Bi. 2017. Modulation of gut microbiota contributes to curcumin-mediated attenuation of hepatic steatosis in rats. Biochimica et Biophysica Acta. General Subjects 1861 (7):1801–12. doi: 10.1016/j.bbagen.2017.03.017.
   PubMed Web of Science ®Google Scholar
• Forlano, R., B. H. Mullish, L. A. Roberts, M. R. Thursz, and P. Manousou. 2022. The intestinal barrier and its dysfunction in patients with metabolic diseases and non-alcoholic fatty liver disease. International Journal of Molecular Sciences 23 (2):662. doi: 10.3390/ijms23020662.
   PubMed Web of Science ®Google Scholar
• Fuchs, C. D., and M. Trauner. 2022. Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology. Nature Reviews. Gastroenterology & Hepatology 19 (7):432–50. doi: 10.1038/s41575-021-00566-7.
   PubMed Web of Science ®Google Scholar
• Fukui, H., B. Brauner, J. C. Bode, and C. Bode. 1991. Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: Reevaluation with an improved chromogenic assay. Journal of Hepatology 12 (2):162–9. doi: 10.1016/0168-8278(91)90933-3.
   PubMed Web of Science ®Google Scholar
• Gadaleta, R. M., and A. Moschetta. 2019. Metabolic messengers: Fibroblast growth factor 15/19. Nature Metabolism 1 (6):588–94. doi: 10.1038/s42255-019-0074-3.
   PubMedGoogle Scholar
• Galaly, S. R., O. M. Ahmed, and A. M. Mahmoud. 2014. Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis. Journal of Physiology and Pharmacology 65 (6):823–32.
   PubMed Web of Science ®Google Scholar
• García-Niño, W. R., E. Tapia, C. Zazueta, Z. L. Zatarain-Barrón, R. Hernández-Pando, C. C. Vega-García, and J. Pedraza-Chaverrí. 2013. Curcumin pretreatment prevents potassium dichromate-induced hepatotoxicity, oxidative stress, decreased respiratory complex I activity, and membrane permeability transition pore opening. Evidence-Based Complementary and Alternative Medicine : eCAM 2013:424692. doi: 10.1155/2013/424692.
   PubMed Web of Science ®Google Scholar
• García-Niño, W. R., Z. L. Zatarain-Barrón, R. Hernández-Pando, C. C. Vega-García, E. Tapia, and J. Pedraza-Chaverri. 2015. Oxidative stress markers and histological analysis in diverse organs from rats treated with a hepatotoxic dose of Cr(VI): Effect of curcumin. Biological Trace Element Research 167 (1):130–45. doi: 10.1007/s12011-015-0283-x.
   PubMed Web of Science ®Google Scholar
• Geng, S., S. Wang, W. Zhu, C. Xie, X. Li, J. Wu, J. Zhu, Y. Jiang, X. Yang, Y. Li, et al. 2018. Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 97:1538–43. doi: 10.1016/j.biopha.2017.11.069.
   PubMed Web of Science ®Google Scholar
• Geng, S., S. Wang, W. Zhu, C. Xie, X. Li, J. Wu, J. Zhu, Y. Jiang, X. Yang, Y. Li, et al. 2017. Curcumin attenuates BPA-induced insulin resistance in HepG2 cells through suppression of JNK/p38 pathways. Toxicology Letters 272:75–83. doi: 10.1016/j.toxlet.2017.03.011.
   PubMed Web of Science ®Google Scholar
• Gheibi, S., H. E. Gouvarchin Ghaleh, B. M. Motlagh, A. F. Azarbayjani, and L. Zarei. 2019. Therapeutic effects of curcumin and ursodexycholic acid on non-alcoholic fatty liver disease. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 115:108938. doi: 10.1016/j.biopha.2019.108938.
   PubMed Web of Science ®Google Scholar
• Giacosa, A., A. Riva, G. Petrangolini, P. Allegrini, T. Fazia, L. Bernardinelli, G. Peroni, and M. Rondanelli. 2022. Beneficial effects on abdominal bloating with an innovative food-grade formulation of Curcuma longa and Boswellia serrata extracts in subjects with irritable bowel syndrome and small bowel dysbiosis. Nutrients 14 (3):416. doi: 10.3390/nu14030416.
   PubMed Web of Science ®Google Scholar
• Giordano, A., and G. Tommonaro. 2019. Curcumin and Cancer. Nutrients 11 (10):2376. doi: 10.3390/nu11102376.
   PubMed Web of Science ®Google Scholar
• Gong, Z., S. Zhao, J. Zhou, J. Yan, L. Wang, X. Du, H. Li, Y. Chen, W. Cai, and J. Wu. 2018. Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1β production. Molecular Immunology 104:11–9. doi: 10.1016/j.molimm.2018.09.004.
   PubMed Web of Science ®Google Scholar
• Granados-Castro, L. F., D. S. Rodríguez-Rangel, B. Fernández-Rojas, J. C. León-Contreras, R. Hernández-Pando, O. N. Medina-Campos, D. Eugenio-Pérez, E. Pinzón, and J. Pedraza-Chaverri. 2016. Curcumin prevents paracetamol-induced liver mitochondrial alterations. The Journal of Pharmacy and Pharmacology 68 (2):245–56. doi: 10.1111/jphp.12501.
   PubMed Web of Science ®Google Scholar
• Gross-Steinmeyer, K., P. L. Stapleton, J. H. Tracy, T. K. Bammler, S. C. Strom, D. R. Buhler, and D. L. Eaton. 2009. Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumols. Toxicological Sciences : An Official Journal of the Society of Toxicology 112 (2):303–10. doi: 10.1093/toxsci/kfp206.
   PubMed Web of Science ®Google Scholar
• Gu, Q., H. Guan, Q. Shi, Y. Zhang, and H. Yang. 2015. Curcumin attenuated acute Propionibacterium acnes-induced liver injury through inhibition of HMGB1 expression in mice. International Immunopharmacology 24 (2):159–65. doi: 10.1016/j.intimp.2014.12.005.
   PubMed Web of Science ®Google Scholar
• Gunnarsdottir, S. A., R. Sadik, S. Shev, M. Simrén, H. Sjövall, P. O. Stotzer, H. Abrahamsson, R. Olsson, and E. S. Björnsson. 2003. Small intestinal motility disturbances and bacterial overgrowth in patients with liver cirrhosis and portal hypertension. The American Journal of Gastroenterology 98 (6):1362–70. doi: 10.1111/j.1572-0241.2003.07475.x.
   PubMed Web of Science ®Google Scholar
• Guo, X., Y. Xu, R. Geng, J. Qiu, and X. He. 2022. Curcumin alleviates dextran sulfate sodium-induced colitis in mice through regulating gut microbiota. Molecular Nutrition & Food Research 66 (8):e2100943. doi: 10.1002/mnfr.202100943.
   PubMed Web of Science ®Google Scholar
• Guo, Y., R. Wu, J. M. Gaspar, D. Sargsyan, Z. Y. Su, C. Zhang, L. Gao, D. Cheng, W. Li, C. Wang, et al. 2018. DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice. Carcinogenesis 39 (5):669–80. doi: 10.1093/carcin/bgy043.
   PubMed Web of Science ®Google Scholar
• Gupta, S. C., G. Kismali, and B. B. Aggarwal. 2013. Curcumin, a component of turmeric: From farm to pharmacy. BioFactors (Oxford, England) 39 (1):2–13. doi: 10.1002/biof.1079.
   PubMed Web of Science ®Google Scholar
• Hanai, H., T. Iida, K. Takeuchi, F. Watanabe, Y. Maruyama, A. Andoh, T. Tsujikawa, Y. Fujiyama, K. Mitsuyama, M. Sata, et al. 2006. Curcumin maintenance therapy for ulcerative colitis: Randomized, multicenter, double-blind, placebo-controlled trial. Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association 4 (12):1502–6. doi: 10.1016/j.cgh.2006.08.008.
   PubMed Web of Science ®Google Scholar
• Harrison, S. A., G. Neff, C. D. Guy, M. R. Bashir, A. H. Paredes, J. P. Frias, Z. Younes, J. F. Trotter, N. T. Gunn, S. E. Moussa, et al. 2021. Efficacy and safety of aldafermin, an engineered FGF19 analog, in a randomized, double-blind, placebo-controlled trial of patients with nonalcoholic steatohepatitis. Gastroenterology 160 (1):219–31.e211. doi: 10.1053/j.gastro.2020.08.004.
   PubMed Web of Science ®Google Scholar
• He, M-m., Z. Fang, D. Hang, F. Wang, G. Polychronidis, L. Wang, C.-H. Lo, K. Wang, R. Zhong, M. D. Knudsen, et al. 2021. Circulating liver function markers and colorectal cancer risk: A prospective cohort study in the UK Biobank. International Journal of Cancer 148 (8):1867–78. doi: 10.1002/ijc.33351.
   PubMed Web of Science ®Google Scholar
• Hong, T., J. Zou, X. Jiang, J. Yang, Z. Cao, Y. He, and D. Feng. 2022. Curcumin supplementation ameliorates bile cholesterol supersaturation in hamsters by modulating gut microbiota and cholesterol absorption. Nutrients 14 (9):1828. doi: 10.3390/nu14091828.
   PubMed Web of Science ®Google Scholar
• Hoofnagle, J. H., and E. S. Björnsson. 2019. Drug-induced liver injury - types and phenotypes. The New England Journal of Medicine 381 (3):264–73. doi: 10.1056/NEJMra1816149.
   PubMed Web of Science ®Google Scholar
• Huang, Y. T., Y. W. Lin, H. M. Chiu, and B. H. Chiang. 2016. Curcumin induces apoptosis of colorectal cancer stem cells by coupling with CD44 marker. Journal of Agricultural and Food Chemistry 64 (11):2247–53. doi: 10.1021/acs.jafc.5b05649.
   PubMed Web of Science ®Google Scholar
• Hyun, J., J. Han, C. Lee, M. Yoon, and Y. Jung. 2021. Pathophysiological aspects of alcohol metabolism in the liver. International Journal of Molecular Sciences 22 (11):5717. doi: 10.3390/ijms22115717.
   PubMed Web of Science ®Google Scholar
• Ibrahim Fouad, G., and K. A. Ahmed. 2022. Curcumin ameliorates doxorubicin-induced cardiotoxicity and hepatotoxicity via suppressing oxidative stress and modulating iNOS, NF-κB, and TNF-α in rats. Cardiovascular Toxicology 22 (2):152–66. doi: 10.1007/s12012-021-09710-w.
   PubMed Web of Science ®Google Scholar
• Jaeschke, H. 2011. Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts. Journal of Gastroenterology and Hepatology 26 Suppl 1:173–9. doi: 10.1111/j.1440-1746.2010.06592.x.
   PubMed Web of Science ®Google Scholar
• Jagetia, G. C., and B. B. Aggarwal. 2007. Spicing up of the immune system by curcumin. Journal of Clinical Immunology 27 (1):19–35. doi: 10.1007/s10875-006-9066-7.
   PubMed Web of Science ®Google Scholar
• Jin, M., L. Kong, Y. Han, and S. Zhang. 2021a. Gut microbiota enhances the chemosensitivity of hepatocellular carcinoma to 5-fluorouracil in vivo by increasing curcumin bioavailability. Phytotherapy Research: PTR 35 (10):5823–37. doi: 10.1002/ptr.7240.
   PubMed Web of Science ®Google Scholar
• Jin, S., H. Yang, Y. Wang, Q. Pang, Y. Jiao, A. Shan, and X. Feng. 2021b. Dietary curcumin alleviated aflatoxin B1-induced acute liver damage in ducks by regulating NLRP3-Caspase-1 signaling pathways. Foods 10 (12):3086. doi: 10.3390/foods10123086.
   PubMed Web of Science ®Google Scholar
• Jones, R. M., and A. S. Neish. 2021. Gut microbiota in intestinal and liver disease. Annual Review of Pathology 16:251–75. doi: 10.1146/annurev-pathol-030320-095722.
   PubMed Web of Science ®Google Scholar
• Kang, Q., and A. Chen. 2009. Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells. British Journal of Pharmacology 157 (8):1354–67. doi: 10.1111/j.1476-5381.2009.00261.x.
   PubMed Web of Science ®Google Scholar
• Kantara, C., M. O’Connell, S. Sarkar, S. Moya, R. Ullrich, and P. Singh. 2014. Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA. Cancer Research 74 (9):2487–98. doi: 10.1158/0008-5472.CAN-13-3536.
   PubMed Web of Science ®Google Scholar
• Khan, H., Z. Ni, H. Feng, Y. Xing, X. Wu, D. Huang, L. Chen, Y. Niu, and G. Shi. 2021. Combination of curcumin with N-n-butyl ­haloperidol iodide inhibits hepatocellular carcinoma malignant proliferation by downregulating enhancer of zeste homolog 2 (EZH2) - lncRNA H19 to silence Wnt/β-catenin signaling. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 91:153706. doi: 10.1016/j.phymed.2021.153706.
   PubMed Web of Science ®Google Scholar
• Kim, K., K. H. Kim, H. Y. Kim, H. K. Cho, N. Sakamoto, and J. Cheong. 2010. Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway. FEBS Letters 584 (4):707–12. doi: 10.1016/j.febslet.2009.12.019.
   PubMed Web of Science ®Google Scholar
• Kocaadam, B., and N. Şanlier. 2017. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Critical Reviews in Food Science and Nutrition 57 (13):2889–95. doi: 10.1080/10408398.2015.1077195.
   PubMed Web of Science ®Google Scholar
• Koh, A., F. De Vadder, P. Kovatcheva-Datchary, and F. Bäckhed. 2016. From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites. Cell 165 (6):1332–45. doi: 10.1016/j.cell.2016.05.041.
   PubMed Web of Science ®Google Scholar
• Kong, D., Z. Zhang, L. Chen, W. Huang, F. Zhang, L. Wang, Y. Wang, P. Cao, and S. Zheng. 2020. Curcumin blunts epithelial-mesenchymal transition of hepatocytes to alleviate hepatic fibrosis through regulating oxidative stress and autophagy. Redox Biology 36:101600. doi: 10.1016/j.redox.2020.101600.
   PubMed Web of Science ®Google Scholar
• Kostic, A. D., R. J. Xavier, and D. Gevers. 2014. The microbiome in inflammatory bowel disease: Current status and the future ahead. Gastroenterology 146 (6):1489–99. doi: 10.1053/j.gastro.2014.02.009.
   PubMed Web of Science ®Google Scholar
• Kuo, J. J., H. H. Chang, T. H. Tsai, and T. Y. Lee. 2012a. Curcumin ameliorates mitochondrial dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosis. International Journal of Molecular Medicine 30 (3):643–9. doi: 10.3892/ijmm.2012.1020.
   PubMed Web of Science ®Google Scholar
• Kuo, J. J., H. H. Chang, T. H. Tsai, and T. Y. Lee. 2012b. Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis. International Journal of Molecular Medicine 30 (3):673–9. doi: 10.3892/ijmm.2012.1049.
   PubMed Web of Science ®Google Scholar
• Lang, A., N. Salomon, J. C. Wu, U. Kopylov, A. Lahat, O. Har-Noy, J. Y. Ching, P. K. Cheong, B. Avidan, D. Gamus, et al. 2015. Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clinical Gastroenterology and Hepatology : The Official Clinical Practice Journal of the American Gastroenterological Association 13 (8):1444–9.e1441. doi: 10.1016/j.cgh.2015.02.019.
   PubMed Web of Science ®Google Scholar
• Larmonier, C. B., M. T. Midura-Kiela, R. Ramalingam, D. Laubitz, N. Janikashvili, N. Larmonier, F. K. Ghishan, and P. R. Kiela. 2011. Modulation of neutrophil motility by curcumin: Implications for inflammatory bowel disease. Inflammatory Bowel Diseases 17 (2):503–15. doi: 10.1002/ibd.21391.
   PubMed Web of Science ®Google Scholar
• Lazarus, J. V., H. E. Mark, Q. M. Anstee, J. P. Arab, R. L. Batterham, L. Castera, H. Cortez-Pinto, J. Crespo, K. Cusi, M. A. Dirac, NAFLD Consensus Consortium, et al. 2022. Advancing the global public health agenda for NAFLD: A consensus statement. Nature Reviews. Gastroenterology & Hepatology 19 (1):60–78. doi: 10.1038/s41575-021-00523-4.
   PubMed Web of Science ®Google Scholar
• Lee, D. E., S. J. Lee, S. J. Kim, H. S. Lee, and O. S. Kwon. 2019. Curcumin ameliorates nonalcoholic fatty liver disease through inhibition of O-GlcNAcylation. Nutrients 11 (11):2702. doi: 10.3390/nu11112702.
   PubMed Web of Science ®Google Scholar
• Lee, Y. H., N. Y. Song, J. Suh, D. H. Kim, W. Kim, J. Ann, J. Lee, J. H. Baek, H. K. Na, and Y. J. Surh. 2018. Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1. Cancer Letters 431:219–29. doi: 10.1016/j.canlet.2018.05.036.
   PubMed Web of Science ®Google Scholar
• Leung, C., L. Rivera, J. B. Furness, and P. W. Angus. 2016. The role of the gut microbiota in NAFLD. Nature Reviews. Gastroenterology & Hepatology 13 (7):412–25. doi: 10.1038/nrgastro.2016.85.
   PubMed Web of Science ®Google Scholar
• Leung, T. M., and N. Nieto. 2013. CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease. Journal of Hepatology 58 (2):395–8. doi: 10.1016/j.jhep.2012.08.018.
   PubMed Web of Science ®Google Scholar
• Li, G., J. B. Chen, C. Wang, Z. Xu, H. Nie, X. Y. Qin, X. M. Chen, and Q. Gong. 2013. Curcumin protects against acetaminophen-induced apoptosis in hepatic injury. World Journal of Gastroenterology 19 (42):7440–6. doi: 10.3748/wjg.v19.i42.7440.
   PubMed Web of Science ®Google Scholar
• Li, G., S. Fang, X. Shao, Y. Li, Q. Tong, B. Kong, L. Chen, Y. Wang, J. Yang, H. Yu, et al. 2021a. Curcumin reverses NNMT-induced 5-fluorouracil resistance via increasing ros and cell cycle arrest in colorectal cancer cells. Biomolecules 11 (9):1295. doi: 10.3390/biom11091295.
   PubMed Web of Science ®Google Scholar
• Li, R., Y. Yao, P. Gao, and S. Bu. 2020. The therapeutic efficacy of curcumin vs. metformin in modulating the gut microbiota in NAFLD rats: A comparative study. Frontiers in Microbiology 11:555293. doi: 10.3389/fmicb.2020.555293.
   PubMed Web of Science ®Google Scholar
• Li, S., X. Wang, Y. Xiao, Y. Wang, Y. Wan, X. Li, Q. Li, X. Tang, D. Cai, B. Ran, et al. 2021b. Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway. Ecotoxicology and Environmental Safety 208:111426. doi: 10.1016/j.ecoenv.2020.111426.
   PubMed Web of Science ®Google Scholar
• Li, Y., W. W. Luo, X. Cheng, H. R. Xiang, B. He, Q. Z. Zhang, and W. X. Peng. 2022. Curcumin attenuates isoniazid-induced hepatotoxicity by upregulating the SIRT1/PGC-1α/NRF1 pathway. Journal of Applied Toxicology: JAT 42 (7):1192–204. doi: 10.1002/jat.4288.
   PubMed Web of Science ®Google Scholar
• Lieber, C. S. 1994. Hepatic and metabolic effects of ethanol: Pathogenesis and prevention. Annals of Medicine 26 (5):325–30. doi: 10.3109/07853899409148346.
   PubMed Web of Science ®Google Scholar
• Lim, T. G., S. Y. Lee, Z. Huang, D. Y. Lim, H. Chen, S. K. Jung, A. M. Bode, K. W. Lee, and Z. Dong. 2014. Curcumin suppresses proliferation of colon cancer cells by targeting CDK2. Cancer Prevention Research (Philadelphia, Pa.) 7 (4):466–74. doi: 10.1158/1940-6207.CAPR-13-0387.
   PubMed Web of Science ®Google Scholar
• Lin, J., and A. Chen. 2008. Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells. Laboratory Investigation; A Journal of Technical Methods and Pathology 88 (5):529–40. doi: 10.1038/labinvest.2008.20.
   PubMed Web of Science ®Google Scholar
• Lin, L. I., Y. F. Ke, Y. C. Ko, and J. K. Lin. 1998. Curcumin inhibits SK-Hep-1 hepatocellular carcinoma cell invasion in vitro and suppresses matrix metalloproteinase-9 secretion. Oncology 55 (4):349–53. doi: 10.1159/000011876.
   PubMed Web of Science ®Google Scholar
• Liu, R., X. Li, W. Zhu, Y. Wang, D. Zhao, X. Wang, E. C. Gurley, G. Liang, W. Chen, G. Lai, et al. 2019. Cholangiocyte-derived exosomal long noncoding RNA H19 promotes hepatic stellate cell activation and cholestatic liver fibrosis. Hepatology (Baltimore, Md.) 70 (4):1317–35. doi: 10.1002/hep.30662.
   PubMed Web of Science ®Google Scholar
• Liu, W., Z. Xu, H. Li, M. Guo, T. Yang, S. Feng, B. Xu, and Y. Deng. 2017. Protective effects of curcumin against mercury-induced hepatic injuries in rats, involvement of oxidative stress antagonism, and Nrf2-ARE pathway activation. Human & Experimental Toxicology 36 (9):949–66. doi: 10.1177/0960327116677355.
   PubMed Web of Science ®Google Scholar
• Liu, Z., C. Li, M. Liu, Z. Song, M. P. Moyer, and D. Su. 2022. The low-density lipoprotein receptor-related protein 6 pathway in the treatment of intestinal barrier dysfunction induced by hypoxia and intestinal microbiota through the Wnt/β-catenin pathway. International Journal of Biological Sciences 18 (11):4469–81. doi: 10.7150/ijbs.72283.
   PubMed Web of Science ®Google Scholar
• Longobardi, C., S. Damiano, E. Andretta, F. Prisco, V. Russo, F. Pagnini, S. Florio, and R. Ciarcia. 2021. Curcumin modulates nitrosative stress, inflammation, and DNA damage and protects against ochratoxin A-induced hepatotoxicity and nephrotoxicity in rats. Antioxidants 10 (8):1239. doi: 10.3390/antiox10081239.
   Web of Science ®Google Scholar
• Lopresti, A. L. 2018. The problem of curcumin and its bioavailability: Could its gastrointestinal influence contribute to its overall health-enhancing effects? Advances in Nutrition (Bethesda, Md.) 9 (1):41–50. doi: 10.1093/advances/nmx011.
   PubMed Web of Science ®Google Scholar
• Lu, C., W. Xu, F. Zhang, J. Shao, and S. Zheng. 2016. Nrf2 knockdown disrupts the protective effect of curcumin on alcohol-induced hepatocyte necroptosis. Molecular Pharmaceutics 13 (12):4043–53. doi: 10.1021/acs.molpharmaceut.6b00562.
   PubMed Web of Science ®Google Scholar
• Lu, C., F. Zhang, W. Xu, X. Wu, N. Lian, H. Jin, Q. Chen, L. Chen, J. Shao, L. Wu, et al. 2015. Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes. IUBMB Life 67 (8):645–58. doi: 10.1002/iub.1409.
   PubMed Web of Science ®Google Scholar
• Lu, Y., X. Li, S. Liu, Y. Zhang, and D. Zhang. 2018. Toll-like receptors and inflammatory bowel disease. Frontiers in Immunology 9:72. doi: 10.3389/fimmu.2018.00072.
   PubMed Web of Science ®Google Scholar
• Lu, Y., S. Wu, B. Xiang, L. Li, and Y. Lin. 2020. Curcumin attenuates oxaliplatin-induced liver injury and oxidative stress by activating the Nrf2 pathway. Drug Design, Development and Therapy 14:73–85. doi: 10.2147/DDDT.S224318.
   PubMed Web of Science ®Google Scholar
• Luca, S. V., I. Macovei, A. Bujor, A. Miron, K. Skalicka-Woźniak, A. C. Aprotosoaie, and A. Trifan. 2020. Bioactivity of dietary polyphenols: The role of metabolites. Critical Reviews in Food Science and Nutrition 60 (4):626–59. doi: 10.1080/10408398.2018.1546669.
   PubMed Web of Science ®Google Scholar
• Luo, D. D., J. F. Chen, J. J. Liu, J. H. Xie, Z. B. Zhang, J. Y. Gu, J. Y. Zhuo, S. Huang, Z. R. Su, and Z. H. Sun. 2019. Tetrahydrocurcumin and octahydrocurcumin, the primary and final hydrogenated metabolites of curcumin, possess superior hepatic-protective effect against acetaminophen-induced liver injury: Role of CYP2E1 and Keap1-Nrf2 pathway. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 123:349–62. doi: 10.1016/j.fct.2018.11.012.
   PubMed Web of Science ®Google Scholar
• Man, S., J. Yao, P. Lv, Y. Liu, L. Yang, and L. Ma. 2020. Curcumin-enhanced antitumor effects of sorafenib via regulating the metabolism and tumor microenvironment. Food & Function 11 (7):6422–32. doi: 10.1039/c9fo01901d.
   PubMed Web of Science ®Google Scholar
• McFadden, R.-M T., C. B. Larmonier, K. W. Shehab, M. Midura-Kiela, R. Ramalingam, C. A. Harrison, D. G. Besselsen, J. H. Chase, J. G. Caporaso, C. Jobin, et al. 2015. The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention. Inflammatory Bowel Diseases 21 (11):2483–94. doi: 10.1097/MIB.0000000000000522.
   PubMed Web of Science ®Google Scholar
• McGlynn, K. A., J. L. Petrick, and H. B. El-Serag. 2021. Epidemiology of Hepatocellular Carcinoma. Hepatology (Baltimore, Md.) 73(Suppl 1):4–13. doi: 10.1002/hep.31288.
   PubMed Web of Science ®Google Scholar
• Midura-Kiela, M. T., V. M. Radhakrishnan, C. B. Larmonier, D. Laubitz, F. K. Ghishan, and P. R. Kiela. 2012. Curcumin inhibits interferon-γ signaling in colonic epithelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology 302 (1):G85–96. doi: 10.1152/ajpgi.00275.2011.
   PubMed Web of Science ®Google Scholar
• Mirhafez, S. R., M. Dehabeh, M. Hariri, A. R. Farimani, A. Movahedi, R. D. Naderan, T. Jamialahmadi, L. E. Simental-Mendía, and A. Sahebkar. 2021. Curcumin and piperine combination for the treatment of patients with non-alcoholic fatty liver disease: A double-blind randomized placebo-controlled trial. Advances in Experimental Medicine and Biology 1328:11–9.
   PubMedGoogle Scholar
• Mirhafez, S. R., A. R. Farimani, M. Dehhabe, M. Bidkhori, M. Hariri, B. F. Ghouchani, and F. Abdollahi. 2019. Effect of phytosomal curcumin on circulating levels of adiponectin and leptin in patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled clinical trial. Journal of Gastrointestinal and Liver Diseases: JGLD 28:183–9. doi: 10.15403/jgld-179.
   PubMed Web of Science ®Google Scholar
• Mishra, B. B., and V. K. Tiwari. 2011. Natural products: An evolving role in future drug discovery. European Journal of Medicinal Chemistry 46 (10):4769–807. doi: 10.1016/j.ejmech.2011.07.057.
   PubMed Web of Science ®Google Scholar
• Mouzaoui, S., S. Banerjee, and B. Djerdjouri. 2020. Low-dose curcumin reduced TNBS-associated mucin depleted foci in mice by scavenging superoxide anion and lipid peroxides, rebalancing matrix NO synthase and aconitase activities, and recoupling mitochondria. Inflammopharmacology 28 (4):949–65. doi: 10.1007/s10787-019-00684-4.
   PubMed Web of Science ®Google Scholar
• Muhammad, I., X. Wang, S. Li, R. Li, and X. Zhang. 2018. Curcumin confers hepatoprotection against AFB(1)-induced toxicity via activating autophagy and ameliorating inflammation involving Nrf2/HO-1 signaling pathway. Molecular Biology Reports 45 (6):1775–85. doi: 10.1007/s11033-018-4323-4.
   PubMed Web of Science ®Google Scholar
• Nahar, M. S., C. Liao, K. Kannan, C. Harris, and D. C. Dolinoy. 2015. In utero bisphenol A concentration, metabolism, and global DNA methylation across matched placenta, kidney, and liver in the human fetus. Chemosphere 124:54–60. doi: 10.1016/j.chemosphere.2014.10.071.
   PubMed Web of Science ®Google Scholar
• Nautiyal, J., S. Banerjee, S. S. Kanwar, Y. Yu, B. B. Patel, F. H. Sarkar, and A. P. Majumdar. 2011. Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells. International Journal of Cancer 128 (4):951–61. doi: 10.1002/ijc.25410.
   PubMed Web of Science ®Google Scholar
• Negi, A. S., J. K. Kumar, S. Luqman, K. Shanker, M. M. Gupta, and S. P. Khanuja. 2008. Recent advances in plant hepatoprotectives: A chemical and biological profile of some important leads. Medicinal Research Reviews 28 (5):746–72. doi: 10.1002/med.20115.
   PubMed Web of Science ®Google Scholar
• Nelson, K. M., J. L. Dahlin, J. Bisson, J. Graham, G. F. Pauli, and M. A. Walters. 2017. The essential medicinal chemistry of curcumin. Journal of Medicinal Chemistry 60 (5):1620–37. doi: 10.1021/acs.jmedchem.6b00975.
   PubMed Web of Science ®Google Scholar
• Neurath, M. F., S. Pettersson, K. H. Meyer Zum Büschenfelde, and W. Strober. 1996. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice. Nature Medicine 2 (9):998–1004. doi: 10.1038/nm0996-998.
   PubMed Web of Science ®Google Scholar
• Nones, K., Y. E. Dommels, S. Martell, C. Butts, W. C. McNabb, Z. A. Park, S. Zhu, D. Hedderley, M. P. Barnett, and N. C. Roy. 2009. The effects of dietary curcumin and rutin on colonic inflammation and gene expression in multidrug resistance gene-deficient (mdr1a-/-) mice, a model of inflammatory bowel diseases. The British Journal of Nutrition 101 (2):169–81. doi: 10.1017/S0007114508009847.
   PubMed Web of Science ®Google Scholar
• Nordenvall, C., O. Olén, P. J. Nilsson, E. von Seth, A. Ekbom, M. Bottai, P. Myrelid, and A. Bergquist. 2018. Colectomy prior to diagnosis of primary sclerosing cholangitis is associated with improved prognosis in a nationwide cohort study of 2594 PSC-IBD patients. Alimentary Pharmacology & Therapeutics 47 (2):238–45. doi: 10.1111/apt.14393.
   PubMed Web of Science ®Google Scholar
• Notarbartolo, M., M. Labbozzetta, F. Pojero, N. D’Alessandro, and P. Poma. 2018. Potential therapeutic applications of MDA-9/syntenin-NF-κB-RKIP loop in human liver carcinoma. Current Molecular Medicine 18 (9):630–9. doi: 10.2174/1566524019666190104105043.
   PubMed Web of Science ®Google Scholar
• Nouri-Vaskeh, M., A. Malek Mahdavi, H. Afshan, L. Alizadeh, and M. Zarei. 2020. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: A randomized controlled trial. Phytotherapy Research : PTR 34 (6):1446–54. doi: 10.1002/ptr.6620.
   PubMed Web of Science ®Google Scholar
• Ohashi, Y., Y. Tsuchiya, K. Koizumi, H. Sakurai, and I. Saiki. 2003. Prevention of intrahepatic metastasis by curcumin in an orthotopic implantation model. Oncology 65 (3):250–8. doi: 10.1159/000074478.
   PubMed Web of Science ®Google Scholar
• Pan, M. H., T. M. Huang, and J. K. Lin. 1999. Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metabolism and Disposition: The Biological Fate of Chemicals 27 (4):486–94.
   PubMed Web of Science ®Google Scholar
• Panahi, Y., P. Kianpour, R. Mohtashami, R. Jafari, L. E. Simental-Mendía, and A. Sahebkar. 2016. Curcumin lowers serum lipids and uric acid in subjects with nonalcoholic fatty liver disease: A randomized controlled trial. Journal of Cardiovascular Pharmacology 68 (3):223–9. doi: 10.1097/FJC.0000000000000406.
   PubMed Web of Science ®Google Scholar
• Panahi, Y., M. Saberi-Karimian, O. Valizadeh, B. Behnam, A. Saadat, T. Jamialahmadi, M. Majeed, and A. Sahebkar. 2021. Effects of curcuminoids on systemic inflammation and quality of life in patients with colorectal cancer undergoing chemotherapy: A randomized controlled trial. Advances in Experimental Medicine and Biology 1328:1–9.
   PubMedGoogle Scholar
• Perkins, S., R. D. Verschoyle, K. Hill, I. Parveen, M. D. Threadgill, R. A. Sharma, M. L. Williams, W. P. Steward, and A. J. Gescher. 2002. Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiology, Biomarkers and Prevention 11 (6):535–40.
   PubMed Web of Science ®Google Scholar
• Pinlaor, S., S. Prakobwong, Y. Hiraku, P. Pinlaor, U. Laothong, and P. Yongvanit. 2010. Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment. European Journal of Pharmacology 638 (1-3):134–41. doi: 10.1016/j.ejphar.2010.04.018.
   PubMed Web of Science ®Google Scholar
• Pivari, F., A. Mingione, C. Brasacchio, and L. Soldati. 2019. Curcumin and type 2 diabetes mellitus: Prevention and treatment. Nutrients 11 (8):1837. doi: 10.3390/nu11081837.
   PubMed Web of Science ®Google Scholar
• Porstmann, T., B. Griffiths, Y. L. Chung, O. Delpuech, J. R. Griffiths, J. Downward, and A. Schulze. 2005. PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24 (43):6465–81. doi: 10.1038/sj.onc.1208802.
   PubMed Web of Science ®Google Scholar
• Portincasa, P., L. Bonfrate, M. L. L. Scribano, A. Kohn, N. Caporaso, D. Festi, M. C. Campanale, T. Di Rienzo, M. Guarino, M. Taddia, et al. 2016. Curcumin and fennel essential oil improve symptoms and quality of life in patients with irritable bowel syndrome. Journal of Gastrointestinal and Liver Diseases: JGLD 25 (2):151–7. doi: 10.15403/jgld.2014.1121.252.ccm.
   PubMed Web of Science ®Google Scholar
• Poursina, Z., A. Mohammadi, S. Z. Yazdi, I. Humpson, V. Vakili, R. Boostani, and H. Rafatpanah. 2019. Curcumin increased the expression of c-FLIP in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. Journal of Cellular Biochemistry 120 (9):15740–5. doi: 10.1002/jcb.28843.
   PubMed Web of Science ®Google Scholar
• Prasad, S., S. C. Gupta, A. K. Tyagi, and B. B. Aggarwal. 2014. Curcumin, a component of golden spice: From bedside to bench and back. Biotechnology Advances 32 (6):1053–64. doi: 10.1016/j.biotechadv.2014.04.004.
   PubMed Web of Science ®Google Scholar
• Qian, H., Y. Yang, and X. Wang. 2011. Curcumin enhanced adriamycin-induced human liver-derived Hepatoma G2 cell death through activation of mitochondria-mediated apoptosis and autophagy. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 43 (3):125–31. doi: 10.1016/j.ejps.2011.04.002.
   PubMed Web of Science ®Google Scholar
• Qin, L., J. Qin, X. Zhen, Q. Yang, and L. Huang. 2018. Curcumin protects against hepatic stellate cells activation and migration by inhibiting the CXCL12/CXCR4 biological axis in liver fibrosis:A study in vitro and in vivo. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 101:599–607. doi: 10.1016/j.biopha.2018.02.091.
   PubMed Web of Science ®Google Scholar
• Qiu, P., J. Sun, S. Man, H. Yang, L. Ma, P. Yu, and W. Gao. 2017. Curcumin attenuates N-nitrosodiethylamine-induced liver injury in mice by utilizing the method of metabonomics. Journal of Agricultural and Food Chemistry 65 (9):2000–7. doi: 10.1021/acs.jafc.6b04797.
   PubMed Web of Science ®Google Scholar
• Rahmani, S., S. Asgary, G. Askari, M. Keshvari, M. Hatamipour, A. Feizi, and A. Sahebkar. 2016. Treatment of non-alcoholic fatty liver disease with curcumin: A randomized placebo-controlled trial. Phytotherapy Research: PTR 30 (9):1540–8. doi: 10.1002/ptr.5659.
   PubMed Web of Science ®Google Scholar
• Ravindranath, V., and N. Chandrasekhara. 1980. Absorption and tissue distribution of curcumin in rats. Toxicology 16 (3):259–65. doi: 10.1016/0300-483x(80)90122-5.
   PubMed Web of Science ®Google Scholar
• Rechtman, M. M., O. Har-Noy, I. Bar-Yishay, S. Fishman, Y. Adamovich, Y. Shaul, Z. Halpern, and A. Shlomai. 2010. Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alpha. FEBS Letters 584 (11):2485–90. doi: 10.1016/j.febslet.2010.04.067.
   PubMed Web of Science ®Google Scholar
• Ren, X., J. Xu, Y. Zhang, G. Chen, Y. Zhang, Q. Huang, and Y. Liu. 2020. Bacterial alterations in post-cholecystectomy patients are associated with colorectal cancer. Frontiers in Oncology 10:1418. doi: 10.3389/fonc.2020.01418.
   PubMed Web of Science ®Google Scholar
• Saadati, S., B. Hatami, Z. Yari, M. A. Shahrbaf, S. Eghtesad, A. Mansour, H. Poustchi, M. Hedayati, M. Aghajanpoor-Pasha, A. Sadeghi, et al. 2019a. The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver disease. European Journal of Clinical Nutrition 73 (3):441–9. doi: 10.1038/s41430-018-0382-9.
   PubMed Web of Science ®Google Scholar
• Saadati, S., A. Sadeghi, A. Mansour, Z. Yari, H. Poustchi, M. Hedayati, B. Hatami, and A. Hekmatdoost. 2019b. Curcumin and inflammation in non-alcoholic fatty liver disease: A randomized, placebo controlled clinical trial. BMC Gastroenterology 19 (1):133– doi: 10.1186/s12876-019-1055-4.
   PubMedGoogle Scholar
• Saber, T. M., A. M. A. Abo-Elmaaty, and H. M. Abdel-Ghany. 2019. Curcumin mitigates mancozeb-induced hepatotoxicity and genotoxicity in rats. Ecotoxicology and Environmental Safety 183:109467. doi: 10.1016/j.ecoenv.2019.109467.
   PubMed Web of Science ®Google Scholar
• Sadeghi, N., A. Mansoori, A. Shayesteh, and S. J. Hashemi. 2020. The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis. Phytotherapy Research: PTR 34 (5):1123–33. doi: 10.1002/ptr.6581.
   PubMed Web of Science ®Google Scholar
• Safari, Z., and P. Gérard. 2019. The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD). Cellular and Molecular Life Sciences : CMLS 76 (8):1541–58. doi: 10.1007/s00018-019-03011-w.
   PubMed Web of Science ®Google Scholar
• Salh, B., K. Assi, V. Templeman, K. Parhar, D. Owen, A. Gómez-Muñoz, and K. Jacobson. 2003. Curcumin attenuates DNB-induced murine colitis. American Journal of Physiology. Gastrointestinal and Liver Physiology 285 (1):G235–243. doi: 10.1152/ajpgi.00449.2002.
   PubMed Web of Science ®Google Scholar
• Sekirov, I., S. L. Russell, L. C. Antunes, and B. B. Finlay. 2010. Gut microbiota in health and disease. Physiological Reviews 90 (3):859–904. doi: 10.1152/physrev.00045.2009.
   PubMed Web of Science ®Google Scholar
• Shabbir, U., M. Rubab, E. B. Daliri, R. Chelliah, A. Javed, and D. H. Oh. 2021. Curcumin, quercetin, catechins and metabolic diseases: The role of gut microbiota. Nutrients 13 (1):206. doi: 10.3390/nu13010206.
   PubMed Web of Science ®Google Scholar
• Shan, D., J. Wang, Q. Di, Q. Jiang, and Q. Xu. 2022. Steatosis induced by nonylphenol in HepG2 cells and the intervention effect of curcumin. Food & Function 13 (1):327–43. doi: 10.1039/d1fo02481g.
   PubMed Web of Science ®Google Scholar
• Shen, L., and H. F. Ji. 2019. Bidirectional interactions between dietary curcumin and gut microbiota. Critical Reviews in Food Science and Nutrition 59 (18):2896–902. doi: 10.1080/10408398.2018.1478388.
   PubMed Web of Science ®Google Scholar
• Shen, L., L. Liu, and H. F. Ji. 2017. Regulative effects of curcumin spice administration on gut microbiota and its pharmacological implications. Food & Nutrition Research 61 (1):1361780. doi: 10.1080/16546628.2017.1361780.
   PubMed Web of Science ®Google Scholar
• Shlomai, A., N. Paran, and Y. Shaul. 2006. PGC-1alpha controls hepatitis B virus through nutritional signals. Proceedings of the National Academy of Sciences of the United States of America 103 (43):16003–8. doi: 10.1073/pnas.0607837103.
   PubMed Web of Science ®Google Scholar
• Si-Tayeb, K., F. P. Lemaigre, and S. A. Duncan. 2010. Organogenesis and development of the liver. Developmental Cell 18 (2):175–89. doi: 10.1016/j.devcel.2010.01.011.
   PubMed Web of Science ®Google Scholar
• Srivastava, R. 1989. Inhibition of neutrophil response by curcumin. Agents and Actions 28 (3-4):298–303. doi: 10.1007/BF01967418.
   PubMedGoogle Scholar
• Stärkel, P., and B. Schnabl. 2016. Bidirectional communication between liver and gut during alcoholic liver disease. Seminars in Liver Disease 36 (4):331–9. doi: 10.1055/s-0036-1593882.
   PubMed Web of Science ®Google Scholar
• Ströfer, M., W. Jelkmann, and R. Depping. 2011. Curcumin decreases survival of Hep3B liver and MCF-7 breast cancer cells: The role of HIF. Strahlentherapie Und Onkologie: Organ Der Deutschen Rontgengesellschaft. 187 (7):393–400. doi: 10.1007/s00066-011-2248-0.
   PubMed Web of Science ®Google Scholar
• Sugimoto, K., H. Hanai, K. Tozawa, T. Aoshi, M. Uchijima, T. Nagata, and Y. Koide. 2002. Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice. Gastroenterology 123 (6):1912–22. doi: 10.1053/gast.2002.37050.
   PubMed Web of Science ®Google Scholar
• Sun, M., W. Wu, Z. Liu, and Y. Cong. 2017. Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases. Journal of Gastroenterology 52 (1):1–8. doi: 10.1007/s00535-016-1242-9.
   PubMed Web of Science ®Google Scholar
• Sun, Q., Q. Niu, Y. Guo, Y. Zhuang, X. Li, J. Liu, N. Li, Z. Li, F. Huang, and Z. Qiu. 2021. Regulation on citrate influx and metabolism through inhibiting SLC13A5 and ACLY: A novel mechanism mediating the therapeutic effects of curcumin on NAFLD. Journal of Agricultural and Food Chemistry 69 (31):8714–25. doi: 10.1021/acs.jafc.1c03105.
   PubMed Web of Science ®Google Scholar
• Teng, C. F., C. H. Yu, H. Y. Chang, W. C. Hsieh, T. H. Wu, J. H. Lin, H. C. Wu, L. B. Jeng, and I. J. Su. 2019. Chemopreventive effect of phytosomal curcumin on hepatitis B virus-related hepatocellular carcinoma in a transgenic mouse model. Scientific Reports 9 (1):10338. doi: 10.1038/s41598-019-46891-5.
   PubMedGoogle Scholar
• Thongsri, P., Y. Pewkliang, S. Borwornpinyo, A. Wongkajornsilp, S. Hongeng, and K. Sa-Ngiamsuntorn. 2021. Curcumin inhibited hepatitis B viral entry through NTCP binding. Scientific Reports 11 (1):19125. doi: 10.1038/s41598-021-98243-x.
   PubMed Web of Science ®Google Scholar
• Tiegs, G., J. Hentschel, and A. Wendel. 1992. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. The Journal of Clinical Investigation 90 (1):196–203. doi: 10.1172/JCI115836.
   PubMed Web of Science ®Google Scholar
• Tu, C. T., B. Han, H. C. Liu, and S. C. Zhang. 2011. Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression. Molecular and Cellular Biochemistry 358 (1-2):53–60. doi: 10.1007/s11010-011-0920-4.
   PubMed Web of Science ®Google Scholar
• Tu, C. T., B. Han, Q. Y. Yao, Y. A. Zhang, H. C. Liu, and S. C. Zhang. 2012a. Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression. International Immunopharmacology 12 (1):151–7. doi: 10.1016/j.intimp.2011.11.005.
   PubMed Web of Science ®Google Scholar
• Tu, C. T., Q. Y. Yao, B. L. Xu, J. Y. Wang, C. H. Zhou, and S. C. Zhang. 2012b. Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: Modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 50 (9):3343–51. doi: 10.1016/j.fct.2012.05.050.
   PubMed Web of Science ®Google Scholar
• Tu, C. T., Q. Y. Yao, B. L. Xu, and S. C. Zhang. 2013. Curcumin protects against concanavalin A-induced hepatitis in mice through inhibiting the cytoplasmic translocation and expression of high mobility group box 1. Inflammation 36 (1):206–15. doi: 10.1007/s10753-012-9536-4.
   PubMed Web of Science ®Google Scholar
• Uzunhisarcikli, M., and A. Aslanturk. 2019. Hepatoprotective effects of curcumin and taurine against bisphenol A-induced liver injury in rats. Environmental Science and Pollution Research International 26 (36):37242–53. doi: 10.1007/s11356-019-06615-8.
   PubMed Web of Science ®Google Scholar
• Valokola, M. G., G. Karimi, B. M. Razavi, M. Kianfar, A. H. Jafarian, M. R. Jaafari, and M. Imenshahidi. 2019. The protective activity of nanomicelle curcumin in bisphenol A-induced cardiotoxicity following subacute exposure in rats. Environmental Toxicology 34 (3):319–29. doi: 10.1002/tox.22687.
   PubMed Web of Science ®Google Scholar
• Vamanu, E., F. Gatea, I. Sârbu, and D. Pelinescu. 2019. An in vitro study of the influence of Curcuma longa extracts on the microbiota modulation process, in patients with hypertension. Pharmaceutics 11 (4):191. doi: 10.3390/pharmaceutics11040191.
   PubMed Web of Science ®Google Scholar
• Varatharajalu, R., M. Garige, L. C. Leckey, K. Reyes-Gordillo, R. Shah, and M. R. Lakshman. 2016. Protective role of dietary curcumin in the prevention of the oxidative stress induced by chronic alcohol with respect to hepatic injury and antiatherogenic markers. Oxidative Medicine and Cellular Longevity 2016:5017460. doi: 10.1155/2016/5017460.
   PubMed Web of Science ®Google Scholar
• Villegas, I., S. Sánchez-Fidalgo, and C. A. de la Lastra. 2011. Chemopreventive effect of dietary curcumin on inflammation-induced colorectal carcinogenesis in mice. Molecular Nutrition & Food Research 55 (2):259–67. doi: 10.1002/mnfr.201000225.
   PubMed Web of Science ®Google Scholar
• Wang, B., X. Gao, B. Liu, Y. Li, M. Bai, Z. Zhang, E. Xu, Z. Xiong, and Y. Hu. 2019. Protective effects of curcumin against chronic alcohol-induced liver injury in mice through modulating mitochondrial dysfunction and inhibiting endoplasmic reticulum stress. Food & Nutrition Research 63. doi: 10.29219/fnr.v63.3567.
   Web of Science ®Google Scholar
• Wang, H. Y., W. Ge, S. Q. Liu, J. Long, Q. Q. Jiang, W. Zhou, Z. Y. Zuo, D. Y. Liu, H. M. Zhao, and Y. B. Zhong. 2022a. Curcumin inhibits T follicular helper cell differentiation in mice with dextran sulfate sodium (DSS)-induced colitis. The American Journal of Chinese Medicine 50 (1):275–93. doi: 10.1142/S0192415X22500100.
   PubMedGoogle Scholar
• Wang, J., S. S. Ghosh, and S. Ghosh. 2017. Curcumin improves intestinal barrier function: Modulation of intracellular signaling, and organization of tight junctions. American Journal of Physiology. Cell Physiology 312 (4):C438–c445. doi: 10.1152/ajpcell.00235.2016.
   PubMed Web of Science ®Google Scholar
• Wang, M. E., Y. C. Chen, I. S. Chen, S. C. Hsieh, S. S. Chen, and C. H. Chiu. 2012. Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes. The Journal of Nutritional Biochemistry 23 (10):1352–66. doi: 10.1016/j.jnutbio.2011.08.004.
   PubMed Web of Science ®Google Scholar
• Wang, Y., F. Liu, M. Liu, X. Zhou, M. Wang, K. Cao, S. Jin, A. Shan, and X. Feng. 2022b. Curcumin mitigates aflatoxin B1-induced liver injury via regulating the NLRP3 inflammasome and Nrf2 signaling pathway. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 161:112823. doi: 10.1016/j.fct.2022.112823.
   PubMed Web of Science ®Google Scholar
• Wei, Z. Q., Y. H. Zhang, C. Z. Ke, H. X. Chen, P. Ren, Y. L. He, P. Hu, D. Q. Ma, J. Luo, and Z. J. Meng. 2017. Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation. World Journal of Gastroenterology 23 (34):6252–60. doi: 10.3748/wjg.v23.i34.6252.
   PubMed Web of Science ®Google Scholar
• Wu, C. S., S. Y. Wu, H. C. Chen, C. A. Chu, H. H. Tang, H. S. Liu, Y. R. Hong, C. F. Huang, G. C. Huang, and C. L. Su. 2019. Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib. The Journal of Nutritional Biochemistry 74:108227. doi: 10.1016/j.jnutbio.2019.108227.
   PubMed Web of Science ®Google Scholar
• Wu, P., R. Huang, Y. L. Xiong, and C. Wu. 2016. Protective effects of curcumin against liver fibrosis through modulating DNA methylation. Chinese Journal of Natural Medicines 14 (4):255–64. doi: 10.1016/S1875-5364(16)30025-5.
   PubMed Web of Science ®Google Scholar
• Xiang, J., Z. Zhang, H. Xie, C. Zhang, Y. Bai, H. Cao, Q. Che, J. Guo, and Z. Su. 2021. Effect of different bile acids on the intestine through enterohepatic circulation based on FXR. Gut Microbes 13 (1):1949095. doi: 10.1080/19490976.2021.1949095.
   PubMed Web of Science ®Google Scholar
• Xiao, Q. P., Y. B. Zhong, Z. P. Kang, J. Q. Huang, W. Y. Fang, S. Y. Wei, J. Long, S. S. Li, H. M. Zhao, and D. Y. Liu. 2022. Curcumin regulates the homeostasis of Th17/Treg and improves the composition of gut microbiota in type 2 diabetic mice with colitis. Phytotherapy Research: PTR 36 (4):1708–23. doi: 10.1002/ptr.7404.
   PubMed Web of Science ®Google Scholar
• Xiong, Z. E., W. G. Dong, B. Y. Wang, Q. Y. Tong, and Z. Y. Li. 2015. Curcumin attenuates chronic ethanol-induced liver injury by inhibition of oxidative stress via mitogen-activated protein kinase/nuclear factor E2-related factor 2 pathway in mice. Pharmacognosy Magazine 11 (44):707–15. doi: 10.4103/0973-1296.165556.
   PubMed Web of Science ®Google Scholar
• Xu, J., Y. Fu, and A. Chen. 2003. Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth. American Journal of Physiology. Gastrointestinal and Liver Physiology 285 (1):G20–30. doi: 10.1152/ajpgi.00474.2002.
   PubMed Web of Science ®Google Scholar
• Yan, C., Y. Zhang, X. Zhang, J. Aa, G. Wang, and Y. Xie. 2018. Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 105:274–81. doi: 10.1016/j.biopha.2018.05.135.
   PubMed Web of Science ®Google Scholar
• Yang, F., X. Tang, L. Ding, Y. Zhou, Q. Yang, J. Gong, G. Wang, Z. Wang, and L. Yang. 2016. Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation. Scientific Reports 6:33052. doi: 10.1038/srep33052.
   PubMed Web of Science ®Google Scholar
• Yao, Q., Y. Lin, X. Li, X. Shen, J. Wang, and C. Tu. 2013. Curcumin ameliorates intrahepatic angiogenesis and capillarization of the sinusoids in carbon tetrachloride-induced rat liver fibrosis. Toxicology Letters 222 (1):72–82. doi: 10.1016/j.toxlet.2013.06.240.
   PubMed Web of Science ®Google Scholar
• Ye, X., L. Y. Wong, J. Kramer, X. Zhou, T. Jia, and A. M. Calafat. 2015. Urinary concentrations of bisphenol A and three other bisphenols in convenience samples of U.S. adults during 2000-2014. Environmental Science & Technology 49 (19):11834–9. doi: 10.1021/acs.est.5b02135.
   PubMed Web of Science ®Google Scholar
• Yu, H., Y. Xie, Z. Zhou, Z. Wu, X. Dai, and B. Xu. 2019. Curcumin regulates the progression of colorectal cancer via LncRNA NBR2/AMPK pathway. Technology in Cancer Research & Treatment 18:1533033819870781. doi: 10.1177/1533033819870781.
   Web of Science ®Google Scholar
• Yuan, T., Z. Yin, Z. Yan, Q. Hao, J. Zeng, L. Li, and J. Zhao. 2020a. Tetrahydrocurcumin ameliorates diabetes profiles of db/db mice by altering the composition of gut microbiota and up-regulating the expression of GLP-1 in the pancreas. Fitoterapia 146:104665. doi: 10.1016/j.fitote.2020.104665.
   PubMed Web of Science ®Google Scholar
• Yuan, Z., Z. Yuan, M. Hasnat, H. Zhang, P. Liang, L. Sun, Z. Jiang, and L. Zhang. 2020b. A new perspective of triptolide-associated hepatotoxicity: The relevance of NF- kappa B and NF- kappa B-mediated cellular FLICE-inhibitory protein. Acta Pharmaceutica Sinica. B 10 (5):861–77. doi: 10.1016/j.apsb.2020.02.009.
   PubMed Web of Science ®Google Scholar
• Yuan, Z., H. Zhang, M. Hasnat, J. Ding, X. Chen, P. Liang, L. Sun, L. Zhang, and Z. Jiang. 2019. A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation. Toxicology 414:45–56. doi: 10.1016/j.tox.2019.01.005.
   PubMed Web of Science ®Google Scholar
• Zhang, F., Y. Zhou, H. Chen, H. Jiang, F. Zhou, B. Lv, and M. Xu. 2022a. Curcumin alleviates DSS-induced anxiety-like behaviors via the microbial-brain-gut axis. Oxidative Medicine and Cellular Longevity 2022:6244757.
   PubMed Web of Science ®Google Scholar
• Zhang, H. H., Y. Zhang, Y. N. Cheng, F. L. Gong, Z. Q. Cao, L. G. Yu, and X. L. Guo. 2018. Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo. Molecular Carcinogenesis 57 (1):44–56. doi: 10.1002/mc.22718.
   PubMed Web of Science ®Google Scholar
• Zhang, M., C. Deng, J. Zheng, J. Xia, and D. Sheng. 2006. Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. International Immunopharmacology 6 (8):1233–42. doi: 10.1016/j.intimp.2006.02.013.
   PubMed Web of Science ®Google Scholar
• Zhang, N., M. Gao, Z. Wang, J. Zhang, W. Cui, J. Li, X. Zhu, H. Zhang, D. H. Yang, and X. Xu. 2021a. Curcumin reverses doxorubicin resistance in colon cancer cells at the metabolic level. Journal of Pharmaceutical and Biomedical Analysis 201:114129. doi: 10.1016/j.jpba.2021.114129.
   PubMed Web of Science ®Google Scholar
• Zhang, N.-Y., M. Qi, L. Zhao, M.-K. Zhu, J. Guo, J. Liu, C.-Q. Gu, S. Rajput, C. Krumm, D.-S. Qi, et al. 2016. Curcumin prevents aflatoxin B1 hepatoxicity by inhibition of cytochrome P450 isozymes in chick liver. Toxins 8 (11):327. doi: 10.3390/toxins8110327.
   PubMed Web of Science ®Google Scholar
• Zhang, S., J. Zhao, J. Hu, H. He, Y. Wei, L. Ji, and X. Ma. 2022b. Gama-aminobutyric acid (GABA) alleviates hepatic inflammation via GABA receptors/TLR4/NF-κB pathways in growing-finishing pigs generated by super-multiparous sows. Animal Nutrition (Zhongguo xu mu Shou yi Xue Hui) 9:280–90. doi: 10.1016/j.aninu.2022.02.001.
   PubMedGoogle Scholar
• Zhang, S., J. Zhao, F. Xie, H. He, L. J. Johnston, X. Dai, C. Wu, and X. Ma. 2021b. Dietary fiber-derived short-chain fatty acids: A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease. Obesity Reviews: An Official Journal of the International Association for the Study of Obesity 22 (11):e13316. doi: 10.1111/obr.13316.
   PubMed Web of Science ®Google Scholar
• Zhao, H. L., C. H. Song, and O. H. Chai. 2012. Negative effects of curcumin on liver injury induced by alcohol. Phytotherapy Research: PTR 26 (12):1857–63. doi: 10.1002/ptr.4664.
   PubMed Web of Science ®Google Scholar
• Zhao, H. M., R. Xu, X. Y. Huang, S. M. Cheng, M. F. Huang, H. Y. Yue, X. Wang, Y. Zou, A. P. Lu, and D. Y. Liu. 2016. Curcumin suppressed activation of dendritic cells via JAK/STAT/SOCS signal in mice with experimental colitis. Frontiers in Pharmacology 7:455. doi: 10.3389/fphar.2016.00455.
   PubMed Web of Science ®Google Scholar
• Zhao, X.-A., G. Chen, Y. Liu, Y. Chen, H. Wu, Y. Xiong, G. Wang, B. Jia, Y. Li, J. Xia, et al. 2018. Curcumin reduces Ly6C(hi) monocyte infiltration to protect against liver fibrosis by inhibiting Kupffer cells activation to reduce chemokines secretion. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 106:868–78. doi: 10.1016/j.biopha.2018.07.028.
   PubMed Web of Science ®Google Scholar
• Zhong, Y., Y. Xiao, J. Gao, Z. Zheng, Z. Zhang, L. Yao, and D. Li. 2022. Curcumin improves insulin sensitivity in high-fat diet-fed mice through gut microbiota. Nutrition & Metabolism 19 (1):76. doi: 10.1186/s12986-022-00712-1.
   PubMed Web of Science ®Google Scholar
• Zhong, Y. B., Z. P. Kang, B. G. Zhou, H. Y. Wang, J. Long, W. Zhou, H. M. Zhao, and D. Y. Liu. 2020. Curcumin regulated the homeostasis of memory T cell and ameliorated dextran sulfate sodium-induced experimental colitis. Frontiers in Pharmacology 11:630244. doi: 10.3389/fphar.2020.630244.
   PubMed Web of Science ®Google Scholar
• Zhou, C., C. Hu, B. Wang, S. Fan, and W. Jin. 2020. Curcumin suppresses cell proliferation, migration, and invasion through modulating miR-21-5p/SOX6 axis in hepatocellular carcinoma. Cancer Biotherapy & Radiopharmaceuticals. doi: 10.1089/cbr.2020.3734.
   Google Scholar
• Zhou, D., Q. Pan, F. Z. Xin, R. N. Zhang, C. X. He, G. Y. Chen, C. Liu, Y. W. Chen, and J. G. Fan. 2017. Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier. World Journal of Gastroenterology 23 (1):60–75. doi: 10.3748/wjg.v23.i1.60.
   PubMed Web of Science ®Google Scholar
• Zhou, M., L. J. Johnston, C. Wu, and X. Ma. 2021. Gut microbiota and its metabolites: Bridge of dietary nutrients and obesity-related diseases. Critical Reviews in Food Science and Nutrition 1–18. doi: 10.1080/10408398.2021.1986466.
   Web of Science ®Google Scholar
• Zia, A., T. Farkhondeh, A. M. Pourbagher-Shahri, and S. Samarghandian. 2021. The role of curcumin in aging and senescence: Molecular mechanisms. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 134:111119.doi: 10.1016/j.biopha.2020.111119.
   PubMed Web of Science ®Google Scholar