A critical review of RG-I pectin: sources, extraction methods, structure, and applications

References

• Ahmadi, S., C. Yu, D. Zaeim, D. Wu, X. Hu, X. Ye, and S. Chen. 2022. Increasing RG-I content and lipase inhibitory activity of pectic polysaccharides extracted from goji berry and raspberry by high-pressure processing. Food Hydrocolloids 126:107477. doi: 10.1016/j.foodhyd.2021.107477.
   Web of Science ®Google Scholar
• Akhtar, M., E. Dickinson, J. Mazoyer, and V. Langendorff. 2002. Emulsion stabilizing properties of depolymerized pectin. Food Hydrocolloids 16 (3):249–56. doi: 10.1016/S0268-005X(01)00095-9.
   Web of Science ®Google Scholar
• Ai, C., X. Guo, J. Lin, T. Zhang, and H. Meng. 2019. Characterization of the properties of amphiphilic, alkaline soluble polysaccharides from sugar beet pulp. Food Hydrocolloids 94:199–209. doi: 10.1016/j.foodhyd.2019.03.022.
   Web of Science ®Google Scholar
• Ai, L., Y.-C. Chung, S.-Y. Lin, K.-C. Lee, P. F.-H. Lai, Y. Xia, G. Wang, and S. W. Cui. 2018. Active pectin fragments of high in vitro antiproliferation activities toward human colon adenocarcinoma cells: Rhamnogalacturonan II. Food Hydrocolloids 83:239–45. doi: 10.1016/j.foodhyd.2018.05.017.
   Web of Science ®Google Scholar
• Alamri, M., A. Mohamed, and S. Hussain. 2013. Effects of alkaline-soluble okra gum on rheological and thermal properties of systems with wheat or corn starch. Food Hydrocolloids 30 (2):541–51. doi: 10.1016/j.foodhyd.2012.07.003.
   Google Scholar
• Alba, K., A. Laws, and V. Kontogiorgos. 2015. Isolation and characterization of acetylated LM-pectins extracted from okra pods. Food Hydrocolloids 43:726–35. doi: 10.1016/j.foodhyd.2014.08.003.
   Web of Science ®Google Scholar
• Alba, K., and V. Kontogiorgos. 2017. Pectin at the oil-water interface: Relationship of molecular composition and structure to functionality. Food Hydrocolloids 68:211–8. doi: 10.1016/j.foodhyd.2016.07.026.
   Web of Science ®Google Scholar
• Alba, K., R. Bingham, and V. Kontogiorgos. 2017. M esoscopic structure of pectin in solution. Biopolymers 107 (6):e23016. doi: 10.1002/bip.23016.
   Web of Science ®Google Scholar
• Bagal-Kestwal, D. R., M. Pan, and B. Chiang. 2019. Properties and applications of gelatin, pectin, and carrageenan gels. Bio Monomers for Green Polymeric Composite Materials, vol. 6, 117–40.
   Google Scholar
• Beukema, M., M. Faas, and P. de Vos. 2020. The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: Impact via gut microbiota and direct effects on immune cells. Experimental & Molecular Medicine 52 (9):1364–76. doi: 10.1038/s12276-020-0449-2.
   PubMed Web of Science ®Google Scholar
• Bindereif, B., H. Eichhöfer, M. Bunzel, H. Karbstein, D. Wefers, and U. Van der Schaaf. 2021. Arabinan side-chains strongly affect the emulsifying properties of acid-extracted sugar beet pectins. Food Hydrocolloids 121:106968. doi: 10.1016/j.foodhyd.2021.106968.
   Web of Science ®Google Scholar
• Bonnin, E., C. Garnier, and M. Ralet. 2014. Pectin-modifying enzymes and pectin-derived materials: Applications and impacts. Applied Microbiology and Biotechnology 98 (2):519–32. doi: 10.1007/s00253-013-5388-6.
   PubMed Web of Science ®Google Scholar
• Caffall, K. H., and D. Mohnen. 2009. The structure, function, and biosynthesis of plant cell wall pectic polysaccharides. Carbohydrate Research 344 (14):1879–900. doi: 10.1016/j.carres.2009.05.021.
   PubMed Web of Science ®Google Scholar
• Cai, R., S. Pan, R. Li, X. Xu, S. Pan, and F. Liu. 2022. Curcumin loading and colon release of pectin gel beads: Effect of different de-esterification method. Food Chemistry 389:133130. doi: 10.1016/j.foodchem.2022.133130.
   PubMedGoogle Scholar
• Cao, J., J. Yang, Z. Wang, M. Lu, and K. Yue. 2020. Modified citrus pectins by UV/H2O2 oxidation at acidic and basic conditions: Structures and in vitro anti-inflammatory, anti-proliferative activities. Carbohydrate Polymers 247:116742. doi: 10.1016/j.carbpol.2020.116742.
   PubMed Web of Science ®Google Scholar
• Cervantes-Paz, B., J. de Jesús Ornelas-Paz, S. Ruiz-Cruz, C. Rios-Velasco, V. Ibarra-Junquera, E. Yahia, and A. Gardea-Béjar. 2017. Effects of pectin on lipid digestion and possible implications for carotenoid bioavailability during pre-absorptive stages: A review. Food Research International (Ottawa, Ont.) 99 (Pt 2):917–27. doi: 10.1016/j.foodres.2017.02.012.
   PubMedGoogle Scholar
• Chen, H., H. Niu, H. Zhang, Y. Yun, W. Chen, Q. Zhong, W. Chen, and X. Fu. 2019. Preparation and properties of ferulic acid-sugar beet pulp pectin ester and its application as a physical and antioxidative stabilizer in a fish oil-water emulsion. International Journal of Biological Macromolecules 139:290–7. doi: 10.1016/j.ijbiomac.2019.07.222.
   PubMed Web of Science ®Google Scholar
• Chen, H., X. Fu, and Z. Luo. 2016. Effect of molecular structure on emulsifying properties of sugar beet pulp pectin. Food Hydrocolloids 54:99–106. doi: 10.1016/j.foodhyd.2015.09.021.
   Web of Science ®Google Scholar
• Chen, M., X. Falourd, and M. Lahaye. 2021. Sequential natural deep eutectic solvent pretreatments of apple pomace: A novel way to promote water extraction of pectin and to tailor its main structural domains. Carbohydrate Polymers 266:118113. doi: 10.1016/j.carbpol.2021.118113.
   PubMedGoogle Scholar
• Chen, S., J. Zheng, L. Zhang, H. Cheng, C. Orfila, X. Ye, and J. Chen. 2021. Synergistic gelling mechanism of RG-I rich citrus pectic polysaccharide at different esterification degree in calcium-induced gelation. Food Chemistry 350:129177. doi: 10.1016/j.foodchem.2021.129177.
   PubMed Web of Science ®Google Scholar
• Chen, X., J. Yang, M. Shen, Y. Chen, Q. Yu, and J. Xie. 2022. Structure, function and advance application of microwave-treated polysaccharide: A review. Trends in Food Science & Technology 123:198–209. doi: 10.1016/j.tifs.2022.03.016.
   Web of Science ®Google Scholar
• Chen, X., W. Xiao, M. Shen, Q. Yu, Y. Chen, J. Yang, and J. Xie. 2022. Changes in polysaccharides structure and bioactivity during Mesona chinensis Benth storage. Current Research in Food Science 5:392–400. doi: 10.1016/j.crfs.2022.01.024.
   PubMedGoogle Scholar
• Chen, X., Y. Wang, M. Shen, Q. Yu, Y. Chen, L. Huang, and J. Xie. 2021. The water-soluble non-starch polysaccharides from natural resources against excessive oxidative stress: A potential health-promoting effect and its mechanisms. International Journal of Biological Macromolecules 171:320–30. doi: 10.1016/j.ijbiomac.2021.01.022.
   PubMed Web of Science ®Google Scholar
• Cheng, H., Z. Zhang, J. Leng, D. Liu, M. Hao, X. Gao, G. Tai, and Y. Zhou. 2013. The inhibitory effects and mechanisms of rhamnogalacturonan I pectin from potato on HT-29 colon cancer cell proliferation and cell cycle progression. International Journal of Food Sciences and Nutrition 64 (1):36–43. doi: 10.3109/09637486.2012.694853.
   PubMed Web of Science ®Google Scholar
• Chengxiao, Y., W. Dongmei, Z. Kai, L. Hou, H. Xiao, T. Ding, D. Liu, X. Ye, R. J. Linhardt, and S. Chen. 2021. Challenges of pectic polysaccharides as a prebiotic from the perspective of fermentation characteristics and anti-colitis activity. Carbohydrate Polymers 270:118377. doi: 10.1016/j.carbpol.2021.118377.
   PubMedGoogle Scholar
• Cho, E., H. Jung, B. Lee, H. Kim, J. Rhee, and S. Yoo. 2019. Green process development for apple-peel pectin production by organic acid extraction. Carbohydrate Polymers 204:97–103. doi: 10.1016/j.carbpol.2018.09.086.
   PubMed Web of Science ®Google Scholar
• Choi, J., A. Synytsya, P. Capek, R. Bleha, R. Pohl, and Y. Park. 2016. Structural analysis and anti-obesity effect of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.). Carbohydrate Polymers 146:187–96. doi: 10.1016/j.carbpol.2016.03.043.
   PubMed Web of Science ®Google Scholar
• Christiaens, S., S. Van Buggenhout, K. Houben, Z. Jamsazzadeh Kermani, K. R. N. Moelants, E. D. Ngouémazong, A. Van Loey, and M. E. G. Hendrickx. 2016. Process–structure–function relations of pectin in food. Critical Reviews in Food Science and Nutrition 56 (6):1021–42. doi: 10.1080/10408398.2012.753029.
   PubMed Web of Science ®Google Scholar
• Cui, J., C. Zhao, S. Zhao, G. Tian, F. Wang, C. Li, F. Wang, and J. Zheng. 2020. Alkali + cellulase-extracted citrus pectins exhibit compact conformation and good fermentation properties. Food Hydrocolloids 108:106079. doi: 10.1016/j.foodhyd.2020.106079.
   Web of Science ®Google Scholar
• Cui, J., W. Ren, C. Zhao, W. Gao, G. Tian, Y. Bao, Y. Lian, and J. Zheng. 2020. The structure–property relationships of acid-and alkali-extracted grapefruit peel pectins. Carbohydrate Polymers 229:115524. doi: 10.1016/j.carbpol.2019.115524.
   PubMedGoogle Scholar
• Daas, P., A. Voragen, and H. Schols. 2000. Characterization of non-esterified galacturonic acid sequences in pectin with endopolygalacturonase. Carbohydrate Research 326 (2):120–9. doi: 10.1016/s0008-6215(00)00037-9.
   PubMedGoogle Scholar
• Dongowski, G., A. Lorenz, and J. Proll. 2002. The degree of methylation influences the degradation of pectin in the intestinal tract of rats and in vitro. The Journal of Nutrition 132 (7):1935–44. doi: 10.1093/jn/132.7.1935.
   PubMed Web of Science ®Google Scholar
• Dou, Z., C. Chen, and X. Fu. 2019. The effect of ultrasound irradiation on the physicochemical properties and α-glucosidase inhibitory effect of blackberry fruit polysaccharide. Food Hydrocolloids 96:568–76. doi: 10.1016/j.foodhyd.2019.06.002.
   Web of Science ®Google Scholar
• Dou, Z., C. Chen, Q. Huang, and X. Fu. 2022. In vitro digestion of the whole blackberry fruit: Bioaccessibility, bioactive variation of active ingredients and impacts on human gut microbiota. Food Chemistry 370:131001. doi: 10.1016/j.foodchem.2021.131001.
   PubMedGoogle Scholar
• Elshahed, M., A. Miron, A. Aprotosoaie, and M. Farag. 2021. Pectin in diet: Interactions with the human microbiome, role in gut homeostasis, and nutrient-drug interactions. Carbohydrate Polymers 255:117388. doi: 10.1016/j.carbpol.2020.117388.
   PubMed Web of Science ®Google Scholar
• Ferreira-Lazarte, A., V. Kachrimanidou, M. Villamiel, R. Rastall, and F. Moreno. 2018. In vitro fermentation properties of pectins and enzymatic-modified pectins obtained from different renewable bioresources. Carbohydrate Polymers 199:482–91. doi: 10.1016/j.carbpol.2018.07.041.
   PubMed Web of Science ®Google Scholar
• Ferreira, S., C. Passos, P. Madureira, M. Vilanova, and M. Coimbra. 2015. Structure–function relationships of immunostimulatory polysaccharides: A review. Carbohydrate Polymers 132:378–96. doi: 10.1016/j.carbpol.2015.05.079.
   PubMed Web of Science ®Google Scholar
• Funami, T., G. Zhang, M. Hiroe, S. Noda, M. Nakauma, I. Asai, M. K. Cowman, S. Al-Assaf, and G. O. Phillips. 2007. Effects of the proteinaceous moiety on the emulsifying properties of sugar beet pectin. Food Hydrocolloids 21 (8):1319–29. doi: 10.1016/j.foodhyd.2006.10.009.
   Web of Science ®Google Scholar
• Funami, T., M. Nakauma, S. Ishihara, R. Tanaka, T. Inoue, and G. Phillips. 2011. Structural modifications of sugar beet pectin and the relationship of structure to functionality. Food Hydrocolloids 25 (2):221–9. doi: 10.1016/j.foodhyd.2009.11.017.
   Web of Science ®Google Scholar
• Gao, X., Y. Zhi, L. Sun, X. Peng, T. Zhang, H. Xue, G. Tai, and Y. Zhou. 2013. The inhibitory effects of a rhamnogalacturonan Ι (RG-I) domain from ginseng pectin on galectin-3 and its structure-activity relationship. The Journal of Biological Chemistry 288 (47):33953–65. doi: 10.1074/jbc.M113.482315.
   PubMedGoogle Scholar
• Gao, X., Y. Zhi, T. Zhang, H. Xue, X. Wang, A. D. Foday, G. Tai, and Y. Zhou. 2012. Analysis of the neutral polysaccharide fraction of MCP and its inhibitory activity on galectin-3. Glycoconjugate Journal 29 (4):159–65. doi: 10.1007/s10719-012-9382-5.
   PubMed Web of Science ®Google Scholar
• Golovchenko, V., V. Khlopin, O. Patova, L. Feltsinger, M. Bilan, A. Dmitrenok, and A. Shashkov. 2022. Pectin from leaves of birch (Betula pendula Roth.): Results of NMR experiments and hypothesis of the RG-I structure. Carbohydrate Polymers 284:119186. doi: 10.1016/j.carbpol.2022.119186.
   PubMedGoogle Scholar
• Grønhaug, T., H. Kiyohara, A. Sveaass, D. Diallo, H. Yamada, and B. Paulsen. 2011. Beta-D-(1→4)-galactan-containing side chains in RG-I regions of pectic polysaccharides from Biophytum petersianum Klotzsch. contribute to expression of immunomodulating activity against intestinal Peyer’s patch cells and macrophages. Phytochemistry 72 (17):2139–47. doi: 10.1016/j.phytochem.2011.08.011.
   PubMed Web of Science ®Google Scholar
• Guillotin, S., E. Bakx, P. Boulenguer, J. Mazoyer, H. Schols, and A. Voragen. 2005. Populations having different GalA blocks characteristics are present in commercial pectins which are chemically similar but have different functionalities. Carbohydrate Polymers 60 (3):391–8. doi: 10.1016/j.carbpol.2005.02.001.
   Web of Science ®Google Scholar
• Ho, G. T. T., A. Ahmed, Y. Zou, T. Aslaksen, H. Wangensteen, and H. Barsett. 2015. Structure–activity relationship of immunomodulating pectins from elderberries. Carbohydrate Polymers 125:314–22. doi: 10.1016/j.carbpol.2015.02.057.
   PubMed Web of Science ®Google Scholar
• Hou, Z., S. Chen, and X. Ye. 2021. High pressure processing accelarated the release of RG-I pectic polysaccharides from citrus peel. Carbohydrate Polymers 263:118005. doi: 10.1016/j.carbpol.2021.118005.
   PubMed Web of Science ®Google Scholar
• Hu, W., S. Chen, D. Wu, J. Zheng, and X. Ye. 2019. Ultrasonic-assisted citrus pectin modification in the bicarbonate-activated hydrogen peroxide system: Chemical and microstructural analysis. Ultrasonics Sonochemistry 58:104576. doi: 10.1016/j.ultsonch.2019.04.036.
   PubMed Web of Science ®Google Scholar
• Hu, W., S. Chen, D. Wu, K. Zhu, and X. Ye. 2021a. Physicochemical and macromolecule properties of RG-I enriched pectin from citrus wastes by manosonication extraction. International Journal of Biological Macromolecules 176:332–41. doi: 10.1016/j.ijbiomac.2021.01.216.
   PubMed Web of Science ®Google Scholar
• Hu, W., S. Chen, D. Wu, K. Zhu, and X. Ye. 2021b. Manosonication assisted extraction and characterization of pectin from different citrus peel wastes. Food Hydrocolloids 121:106952. doi: 10.1016/j.foodhyd.2021.106952.
   Google Scholar
• Hu, W., X. Ye, T. Chantapakul, S. Chen, and J. Zheng. 2020. Manosonication extraction of RG-I pectic polysaccharides from citrus waste: Optimization and kinetics analysis. Carbohydrate Polymers 235:115982. doi: 10.1016/j.carbpol.2020.115982.
   PubMed Web of Science ®Google Scholar
• Hughes, R. 2001. Galectins as modulators of cell adhesion. Biochimie 83 (7):667–76.
   PubMed Web of Science ®Google Scholar
• Hwang, J., and J. Kokini. 1992. Contribution of the side branches to rheological properties of pectins. Carbohydrate Polymers 19 (1):41–50. doi: 10.1016/0144-8617(92)90053-S.
   Google Scholar
• Jin, M., M. Li, R. Huang, X. Wu, Y. Sun, and Z. Xu. 2021. Structural features and anti-inflammatory properties of pectic polysaccharides: A review. Trends in Food Science & Technology 107:284–98. doi: 10.1016/j.tifs.2020.10.042.
   Web of Science ®Google Scholar
• Joanna, B., B. Michal, D. Piotr, W. Agnieszka, K. Dorota, and W. Izabela. 2018. Sugar beet pulp as a source of valuable biotechnological products. In Advances in biotechnology for food industry, 359–92. doi: 10.1016/B978-0-12-811443-8.00013-X.
   Google Scholar
• Kaczmarska, A., P. Pieczywek, J. Cybulska, and A. Zdunek. 2022. Structure and functionality of Rhamnogalacturonan I in the cell wall and in solution: A review. Carbohydrate Polymers 278:118909. doi: 10.1016/j.carbpol.2021.118909.
   PubMedGoogle Scholar
• Kaya, M., A. Sousa, M. Crépeau, S. Sørensen, and M. Ralet. 2014. Characterization of citrus pectin samples extracted under different conditions: Influence of acid type and pH of extraction. Annals of Botany 114 (6):1319–26. doi: 10.1093/aob/mcu150.
   PubMed Web of Science ®Google Scholar
• Khedmat, L.,A. Izadi,V. Mofid, andS. Y. Mojtahedi. 2020. Recent advances in extracting pectin by single and combined ultrasound techniques: A review of techno-functional and bioactive health-promoting aspects. Carbohydrate Polymers 229:115474. doi: 10.1016/j.carbpol.2019.115474.
   PubMed Web of Science ®Google Scholar
• Khodaei, N., and S. Karboune. 2013. Extraction and structural characterisation of rhamnogalacturonan I-type pectic polysaccharides from potato cell wall. Food Chemistry 139 (1-4):617–23. doi: 10.1016/j.foodchem.2013.01.110.
   PubMed Web of Science ®Google Scholar
• Khodaei, N., and S. Karboune. 2014. Enzymatic extraction of galactan-rich rhamnogalacturonan I from potato cell wall by-product. LWT – Food Science and Technology 57 (1):207–16. doi: 10.1016/j.lwt.2013.12.034.
   Web of Science ®Google Scholar
• Khodaei, N., S. Karboune, and V. Orsat. 2016. Microwave-assisted alkaline extraction of galactan-rich rhamnogalacturonan I from potato cell wall by-product. Food Chemistry 190:495–505. doi: 10.1016/j.foodchem.2015.05.082.
   PubMed Web of Science ®Google Scholar
• Klaassen, M., and L. Trindade. 2020. RG-I galactan side-chains are involved in the regulation of the water-binding capacity of potato cell walls. Carbohydrate Polymers 227:115353. doi: 10.1016/j.carbpol.2019.115353.
   PubMed Web of Science ®Google Scholar
• Kontogiorgos, V. 2019. Polysaccharides at fluid interfaces of food systems. Advances in Colloid and Interface Science 270:28–37. doi: 10.1016/j.cis.2019.05.008.
   PubMed Web of Science ®Google Scholar
• Košťálová, Z., Z. Hromádková, and A. Ebringerová. 2013. Structural diversity of pectins isolated from the Styrian oil-pumpkin (Cucurbita pepo var. styriaca) fruit. Carbohydrate Polymers 93 (1):163–71. doi: 10.1016/j.carbpol.2012.05.017.
   PubMed Web of Science ®Google Scholar
• Kpodo, F., J. Agbenorhevi, K. Alba, R. Bingham, I. Oduro, G. Morris, and V. Kontogiorgos. 2017. Pectin isolation and characterization from six okra genotypes. Food Hydrocolloids 72:323–30. doi: 10.1016/j.foodhyd.2017.06.014.
   Web of Science ®Google Scholar
• Kumar, M., M. Tomar, V. Saurabh, M. Sasi, S. Punia, J. Potkule, C. Maheshwari, S. Changan, B. Bhushan, S. Singh, et al. 2021. Delineating the inherent functional descriptors and biofunctionalities of pectic polysaccharides. Carbohydrate Polymers 269:118319. doi: 10.1016/j.carbpol.2021.118319.
   PubMedGoogle Scholar
• Langner, E., W. Rzeski, J. Kaczor, and M. Kandefer-Szerszen. 2009. Tumour cell growth-inhibiting properties of water extract isolated from heated potato fibre (Potex). Journal of Pre-Clinical and Clinical Research 3 (1):36–41.
   Google Scholar
• Larsen, F., I. Byg, I. Damager, J. Diaz, S. Engelsen, and P. Ulvskov. 2011. Residue specific hydration of primary cell wall potato pectin identified by solid-state 13C single-pulse MAS and CP/MAS NMR spectroscopy. Biomacromolecules 12 (5):1844–50. doi: 10.1021/bm2001928.
   PubMedGoogle Scholar
• Larsen, N., C. Bussolo de Souza, L. Krych, T. Barbosa Cahú, M. Wiese, W. Kot, K. M. Hansen, A. Blennow, K. Venema, and L. Jespersen. 2019. Potential of pectins to beneficially modulate the gut microbiota depends on their structural properties. Frontiers in Microbiology 10:223. doi: 10.3389/fmicb.2019.00223.
   PubMed Web of Science ®Google Scholar
• Lee, H., Y. Kim, and H. Park. 2022. Pectic polysaccharides: Targeting gut microbiota in obesity and intestinal health. Carbohydrate Polymers 287:119363. doi: 10.1016/j.carbpol.2022.119363.
   PubMed Web of Science ®Google Scholar
• Leroux, J., V. Langendorff, G. Schick, V. Vaishnav, and J. Mazoyer. 2003. Emulsion stabilizing properties of pectin. Food Hydrocolloids 17 (4):455–62. doi: 10.1016/S0268-005X(03)00027-4.
   Web of Science ®Google Scholar
• Li, J., X. Yang, X. Li, Z. Zhang, Z. Wei, Z. Xing, S. Deng, and F. Duan. 2020. Okra polysaccharides/gelatin complex coacervate as pH-responsive and intestine-targeting delivery protects isoquercitin bioactivity. International Journal of Biological Macromolecules 159:487–96. doi: 10.1016/j.ijbiomac.2020.05.067.
   PubMedGoogle Scholar
• Li, X., Y. Dong, Y. Guo, Z. Zhang, L. Jia, H. Gao, Z. Xing, and F. Duan. 2019. Okra polysaccharides reduced the gelling-required sucrose content in its synergistic gel with high-methoxyl pectin by microphase separation effect. Food Hydrocolloids 95:506–16. doi: 10.1016/j.foodhyd.2019.04.069.
   Web of Science ®Google Scholar
• Li, X., Z. Wei, X. Wang, F. Duan, L. Xiong, J. Li, J. Tian, L. Jia, and H. Gao. 2021. Premna microphylla Turcz leaf pectin exhibited antioxidant and anti-inflammatory activities in LPS-stimulated RAW 264.7 macrophages. Food Chemistry 349:129164. doi: 10.1016/j.foodchem.2021.129164.
   PubMed Web of Science ®Google Scholar
• Liu, H., L. Deng, T. Dai, J. Chen, W. Liu, C. Liu, M. Chen, and R. Liu. 2022. Emulsifying and emulsion stabilization mechanism of pectin from Nicandra physaloides (Linn.) Gaertn seeds: Comparison with apple and citrus pectin. Food Hydrocolloids 130:107674. doi: 10.1016/j.foodhyd.2022.107674.
   Google Scholar
• Lo, T., C. Chang, K. Chiu, P. Tsay, and J. Jen. 2011. Correlation evaluation of antioxidant properties on the monosaccharide components and glycosyl linkages of polysaccharide with different measuring methods. Carbohydrate Polymers 86 (1):320–7. doi: 10.1016/j.carbpol.2011.04.056.
   Web of Science ®Google Scholar
• Makshakova, O., D. Faizullin, P. Mikshina, T. Gorshkova, and Y. Zuev. 2018. Spatial structures of rhamnogalacturonan I in gel and colloidal solution identified by 1D and 2D-FTIR spectroscopy. Carbohydrate Polymers 192:231–9. doi: 10.1016/j.carbpol.2018.03.059.
   PubMedGoogle Scholar
• Maksymowicz, J., A. Palko-Łabuz, B. Sobieszczańska, M. Chmielarz, M. Ferens-Sieczkowska, M. Skonieczna, A. Wikiera, O. Wesołowska, and K. Środa-Pomianek. 2022. The use of endo-cellulase and endo-xylanase for the extraction of apple pectins as factors modifying their anticancer properties and affecting their synergy with the active form of irinotecan. Pharmaceuticals 15 (6):732. doi: 10.3390/ph15060732.
   Google Scholar
• Mao, G., S. Li, C. Orfila, X. Shen, S. Zhou, R. J. Linhardt, X. Ye, and S. Chen. 2019. Depolymerized RG-I-enriched pectin from citrus segment membranes modulates gut microbiota, increases SCFA production, and promotes the growth of Bifidobacterium spp., Lactobacillus spp. and Faecalibaculum spp. Food & Function 10 (12):7828–43. doi: 10.1039/c9fo01534e.
   PubMed Web of Science ®Google Scholar
• Mao, Y., R. Lei, J. Ryan, F. Arrutia Rodriguez, B. Rastall, A. Chatzifragkou, C. Winkworth-Smith, S. E. Harding, R. Ibbett, and E. Binner. 2019. Understanding the influence of processing conditions on the extraction of rhamnogalacturonan-I “hairy” pectin from sugar beet pulp. Food Chemistry: X 2:100026. doi: 10.1016/j.fochx.2019.100026.
   PubMedGoogle Scholar
• Mao, Y., R. Millett, C. Lee, G. Yakubov, S. Harding, and E. Binner. 2020. Investigating the influence of pectin content and structure on its functionality in bio-flocculant extracted from okra. Carbohydrate Polymers 241:116414. doi: 10.1016/j.carbpol.2020.116414.
   PubMedGoogle Scholar
• Maria-Ferreira, D., A. M. Nascimento, T. R. Cipriani, A. P. Santana-Filho, P. S. Watanabe, D. M. G. Sant’Ana, F. B. Luciano, K. C. P. Bocate, R. M. van den Wijngaard, M. F. P. Werner, et al. 2018. Rhamnogalacturonan, a chemically-defined polysaccharide, improves intestinal barrier function in DSS-induced colitis in mice and human Caco-2 cells. Scientific Reports 8 (1):1–14. doi: 10.1038/s41598-018-30526-2.
   PubMedGoogle Scholar
• Maxwell, E., I. Colquhoun, H. Chau, A. Hotchkiss, K. Waldron, V. Morris, and N. Belshaw. 2015. Rhamnogalacturonan I containing homogalacturonan inhibits colon cancer cell proliferation by decreasing ICAM1 expression. Carbohydrate Polymers 132:546–53. doi: 10.1016/j.carbpol.2015.06.082.
   PubMed Web of Science ®Google Scholar
• Maxwell, E., I. Colquhoun, H. Chau, A. Hotchkiss, K. Waldron, V. Morris, and N. Belshaw. 2016. Modified sugar beet pectin induces apoptosis of colon cancer cells via an interaction with the neutral sugar side-chains. Carbohydrate Polymers 136:923–9. doi: 10.1016/j.carbpol.2015.09.063.
   PubMed Web of Science ®Google Scholar
• Maxwell, E., N. Belshaw, K. Waldron, and V. Morris. 2012. Pectin–An emerging new bioactive food polysaccharide. Trends in Food Science & Technology 24 (2):64–73. doi: 10.1016/j.tifs.2011.11.002.
   Web of Science ®Google Scholar
• McClements, D. J. 2007. Critical review of techniques and methodologies for characterization of emulsion stability. Critical Reviews in Food Science and Nutrition 47 (7):611–49. doi: 10.1080/10408390701289292.
   PubMed Web of Science ®Google Scholar
• McClements, D. J., and E. A. Decker. 2000. Lipid oxidation in oil‐in‐water emulsions: Impact of molecular environment on chemical reactions in heterogeneous food systems. Journal of Food Science 65 (8):1270–82. doi: 10.1111/j.1365-2621.2000.tb10596.x.
   Web of Science ®Google Scholar
• Meresta, A., J. Folkert, T. Gaber, K. Miksch, F. Buttgereit, J. Detert, N. Pischon, and K. Gurzawska. 2017. Plant-derived pectin nanocoatings to prevent inflammatory cellular response of osteoblasts following Porphyromonas gingivalis infection. International Journal of Nanomedicine 12:433–45. doi: 10.2147/IJN.S113740.
   PubMedGoogle Scholar
• Mieszkowska, A., J. Folkert, T. Gaber, K. Miksch, and K. Gurzawska. 2017. Pectin nanocoating reduces proinflammatory fibroblast response to bacteria. Journal of Biomedical Materials Research. Part A 105 (12):3475–81. doi: 10.1002/jbm.a.36170.
   PubMedGoogle Scholar
• Mikshina, P., O. Makshakova, A. Petrova, I. Gaifullina, B. Idiyatullin, T. Gorshkova, and Y. Zuev. 2017. Gelation of rhamnogalacturonan I is based on galactan side chain interaction and does not involve chemical modifications. Carbohydrate Polymers 171:143–51. doi: 10.1016/j.carbpol.2017.05.013.
   PubMedGoogle Scholar
• Morris, G., and M. Ralet. 2012. The effect of neutral sugar distribution on the dilute solution conformation of sugar beet pectin. Carbohydrate Polymers 88 (4):1488–91. doi: 10.1016/j.carbpol.2012.02.020.
   Google Scholar
• Morris, G., M. Ralet, E. Bonnin, J. Thibault, and S. Harding. 2010. Physical characterisation of the rhamnogalacturonan and homogalacturonan fractions of sugar beet (Beta vulgaris) pectin. Carbohydrate Polymers 82 (4):1161–7. doi: 10.1016/j.carbpol.2010.06.049.
   Web of Science ®Google Scholar
• Moslemi, M. 2021. Reviewing the recent advances in application of pectin for technical and health promotion purposes: From laboratory to market. Carbohydrate Polymers 254:117324. doi: 10.1016/j.carbpol.2020.117324.
   PubMed Web of Science ®Google Scholar
• Nakamura, A., H. Furuta, H. Maeda, T. Takao, and Y. Nagamatsu. 2002. Structural studies by stepwise enzymatic degradation of the main backbone of soybean soluble polysaccharides consisting of galacturonan and rhamnogalacturonan. Bioscience, Biotechnology, and Biochemistry 66 (6):1301–13. doi: 10.1271/bbb.66.1301.
   PubMed Web of Science ®Google Scholar
• Naqash, F., F. Masoodi, S. Rather, S. Wani, and A. Gani. 2017. Emerging concepts in the nutraceutical and functional properties of pectin–A Review. Carbohydrate Polymers 168:227–39. doi: 10.1016/j.carbpol.2017.03.058.
   PubMed Web of Science ®Google Scholar
• Ndeh, D., A. Rogowski, A. Cartmell, A. S. Luis, A. Baslé, J. Gray, I. Venditto, J. Briggs, X. Zhang, A. Labourel, et al. 2017. Complex pectin metabolism by gut bacteria reveals novel catalytic functions. Nature 544 (7648):65–70. doi: 10.1038/nature21725.
   PubMed Web of Science ®Google Scholar
• Neckebroeck, B., S. Verkempinck, G. Vaes, K. Wouters, J. Magnée, M. Hendrickx, and A. Van Loey. 2020. Advanced insight into the emulsifying and emulsion stabilizing capacity of carrot pectin subdomains. Food Hydrocolloids 102:105594. doi: 10.1016/j.foodhyd.2019.105594.
   Web of Science ®Google Scholar
• Ngouémazong, D., G. Kabuye, I. Fraeye, R. Cardinaels, A. Van Loey, P. Moldenaers, and M. Hendrickx. 2012. Effect of debranching on the rheological properties of Ca2+–pectin gels. Food Hydrocolloids 26 (1):44–53. doi: 10.1016/j.foodhyd.2011.04.009.
   Web of Science ®Google Scholar
• Ngouémazong, E., S. Christiaens, A. Shpigelman, A. Van Loey, and M. Hendrickx. 2015. The emulsifying and emulsion‐stabilizing properties of pectin: A review. Comprehensive Reviews in Food Science and Food Safety 14 (6):705–18. doi: 10.1111/1541-4337.12160.
   Web of Science ®Google Scholar
• Nicholson, J. K., E. Holmes, J. Kinross, R. Burcelin, G. Gibson, W. Jia, and S. Pettersson. 2012. Host-gut microbiota metabolic interactions. Science (New York, N.Y.) 336 (6086):1262–7. doi: 10.1126/science.1223813.
   PubMed Web of Science ®Google Scholar
• Ning, X., Y. Liu, M. Jia, Q. Wang, Z. Sun, L. Ji, K. H. Mayo, Y. Zhou, and L. Sun. 2021. Pectic polysaccharides from Radix Sophorae Tonkinensis exhibit significant antioxidant effects. Carbohydrate Polymers 262:117925. doi: 10.1016/j.carbpol.2021.117925.
   PubMedGoogle Scholar
• Niu, H., K. Hou, H. Chen, and X. Fu. 2022. A review of sugar beet pectin-stabilized emulsion: Extraction, structure, interfacial self-assembly and emulsion stability. Critical Reviews in Food Science and Nutrition 1–21. doi: 10.1080/10408398.2022.2109586.
   Google Scholar
• Niu, H., W. Chen, W. Chen, Y. Yun, Q. Zhong, X. Fu, H. Chen, and G. Liu. 2019. Preparation and characterization of a modified-β-cyclodextrin/β-carotene inclusion complex and its application in pickering emulsions. Journal of Agricultural and Food Chemistry 67 (46):12875–84. doi: 10.1021/acs.jafc.9b05467.
   PubMed Web of Science ®Google Scholar
• Niu, H., W. Wang, Z. Dou, X. Chen, X. Chen, H. Chen, and X. Fu. 2023. Multiscale combined techniques for evaluating emulsion stability: A critical review. Advances in Colloid and Interface Science 311:102813. doi: 10.1016/j.cis.2022.102813.
   PubMed Web of Science ®Google Scholar
• Niu, H., X. Chen, T. Luo, H. Chen, and X. Fu. 2022a. Relationships between the behavior of three different sources of pectin at the oil-water interface and the stability of the emulsion. Food Hydrocolloids . 128:107566. doi: 10.1016/j.foodhyd.2022.107566.
   Web of Science ®Google Scholar
• Niu, H., X. Chen, T. Luo, H. Chen, and X. Fu. 2022b. The interfacial behavior and long-term stability of emulsions stabilized by gum arabic and sugar beet pectin. Carbohydrate Polymers 291:119623. doi: 10.1016/j.carbpol.2022.119623.
   PubMed Web of Science ®Google Scholar
• Noreen, A., Z.-I.-H. Nazli, J. Akram, I. Rasul, A. Mansha, N. Yaqoob, R. Iqbal, S. Tabasum, M. Zuber, and K. M. Zia. 2017. Pectins functionalized biomaterials; a new viable approach for biomedical applications: A review. International Journal of Biological Macromolecules 101:254–72. doi: 10.1016/j.ijbiomac.2017.03.029.
   PubMed Web of Science ®Google Scholar
• Ogawa, S., E. Decker, and D. McClements. 2003. Influence of environmental conditions on the stability of oil in water emulsions containing droplets stabilized by lecithin-chitosan membranes. Journal of Agricultural and Food Chemistry 51 (18):5522–7. doi: 10.1021/jf026103d.
   PubMed Web of Science ®Google Scholar
• Ognyanov, M., M. Nikolova, I. Yanakieva, V. Kussovski, and M. Kratchanova. 2013. Influence of composition on the biological activity of pectic polysaccharides from leek. Journal of BioScience & Biotechnology 2 (1):13–20.
   Google Scholar
• Olano-Martin, E., G. R. Gibson, and R. A. Rastell. 2002. Comparison of the in vitro bifidogenic properties of pectins and pectic‐oligosaccharides. Journal of Applied Microbiology 93 (3):505–11. doi: 10.1046/j.1365-2672.2002.01719.x.
   PubMed Web of Science ®Google Scholar
• O’Neill, M. A., I. Black, B. Urbanowicz, V. Bharadwaj, M. Crowley, S. Koj, and M. J. Peña. 2020. Locating methyl-etherified and methyl-esterified uronic acids in the plant cell wall pectic polysaccharide Rhamnogalacturonan II. SLAS Technology 25 (4):329–44. doi: 10.1177/2472630320923321.
   PubMedGoogle Scholar
• O’Neill, M., S. Eberhard, P. Albersheim, and G. Darvill. 2001. Requirement of borate cross-linking of cell wall rhamnogalacturonan II for Arabidopsis growth. Science (New York, N.Y.) 294 (5543):846–9. doi: 10.1126/science.1062319.
   PubMedGoogle Scholar
• O’Neill, M., T. Ishii, P. Albersheim, and A. Darvill. 2004. Rhamnogalacturonan II: Structure and function of a borate cross-linked cell wall pectic polysaccharide. Annual Review of Plant Biology 55:109–39. doi: 10.1146/annurev.arplant.55.031903.141750.
   PubMed Web of Science ®Google Scholar
• Pellerin, P., T. Doco, S. Vida, P. Williams, J. M. Brillouet, and M. A. O’Neill. 1996. Structural characterization of red wine rhamnogalacturonan II. Carbohydrate Research 290 (2):183–97. doi: 10.1016/0008-6215(96)00139-5.
   PubMed Web of Science ®Google Scholar
• Sabater, C., J. Molina-Tijeras, T. Vezza, N. Corzo, A. Montilla, and P. Utrilla. 2019. Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers. Food & Function 10 (12):7793–805. doi: 10.1039/c9fo02221j.
   PubMed Web of Science ®Google Scholar
• Sahasrabudhe, N. M., M. Beukema, L. Tian, B. Troost, J. Scholte, E. Bruininx, G. Bruggeman, M. van den Berg, A. Scheurink, H. A. Schols, et al. 2018. Dietary fiber pectin directly blocks toll-like receptor 2–1 and prevents doxorubicin-induced ileitis. Frontiers in Immunology 9:383. doi: 10.3389/fimmu.2018.00383.
   PubMed Web of Science ®Google Scholar
• Schmidt, U., L. Koch, C. Rentschler, T. Kurz, H. Endreß, and H. Schuchmann. 2015. Effect of molecular weight reduction, acetylation and esterification on the emulsification properties of citrus pectin. Food Biophysics 10 (2):217–27. doi: 10.1007/s11483-014-9380-1.
   Web of Science ®Google Scholar
• Schols, H., and A. Voragen. 1996. Complex pectins: Structure elucidation using enzymes. In Progress in biotechnology, Vol. 14, 3–19. Elsevier. doi:10.1016/S0921-0423(96)80242-5.
   Google Scholar
• Sengkhamparn, N., E. Bakx, R. Verhoef, H. Schols, T. Sajjaanantakul, and A. Voragen. 2009. Okra pectin contains an unusual substitution of its rhamnosyl residues with acetyl and alpha-linked galactosyl groups. Carbohydrate Research 344 (14):1842–51. doi: 10.1016/j.carres.2008.11.022.
   PubMed Web of Science ®Google Scholar
• Sengkhamparn, N., R. Verhoef, H. Schols, T. Sajjaanantakul, and A. Voragen. 2009. Characterisation of cell wall polysaccharides from okra (Abelmoschus esculentus (L.) Moench). Carbohydrate Research 344 (14):1824–32. doi: 10.1016/j.carres.2008.10.012.
   PubMed Web of Science ®Google Scholar
• Sheng, J., and Y. Sun. 2014. Antioxidant properties of different molecular weight polysaccharides from Athyrium multidentatum (Doll.) Ching. Carbohydrate Polymers 108:41–5. doi: 10.1016/j.carbpol.2014.03.011.
   PubMed Web of Science ®Google Scholar
• Siew, C. K., and P. A. Williams. 2008. Role of protein and ferulic acid in the emulsification properties of sugar beet pectin. Journal of Agricultural and Food Chemistry 56 (11):4164–71. doi: 10.1021/jf073358o.
   PubMed Web of Science ®Google Scholar
• Sila, D., S. Van Buggenhout, T. Duvetter, I. Fraeye, A. De Roeck, A. Van Loey, and M. Hendrickx. 2009. Pectins in processed fruits and vegetables: Part II—Structure–function relationships. Comprehensive Reviews in Food Science and Food Safety 8 (2):86–104. doi: 10.1111/j.1541-4337.2009.00071.x.
   Web of Science ®Google Scholar
• Son, S. U., H. W. Lee, and K. S. Shin. 2023. Immunostimulating activities and anti-cancer efficacy of rhamnogalacturonan-I rich polysaccharide purified from Panax ginseng leaf. Food Bioscience 53:102618. doi: 10.1016/j.fbio.2023.102618.
   Google Scholar
• Sousa, A., H. Nielsen, I. Armagan, J. Larsen, and S. Sørensen. 2015. The impact of rhamnogalacturonan-I side chain monosaccharides on the rheological properties of citrus pectin. Food Hydrocolloids 47:130–9. doi: 10.1016/j.foodhyd.2015.01.013.
   Web of Science ®Google Scholar
• Tan, H., and S. Nie. 2020. Deciphering diet-gut microbiota-host interplay: Investigations of pectin. Trends in Food Science & Technology 106:171–81. doi: 10.1016/j.tifs.2020.10.010.
   Web of Science ®Google Scholar
• Tang, S., M. Jiang, C. Huang, C. Lai, Y. Fan, and Q. Yong. 2018. Characterization of arabinogalactans from Larix principis-rupprechtii and their effects on NO production by macrophages. Carbohydrate Polymers 200:408–15. doi: 10.1016/j.carbpol.2018.08.027.
   PubMed Web of Science ®Google Scholar
• Torkova, A., K. Lisitskaya, I. Filimonov, O. Glazunova, G. Kachalova, V. Golubev, and T. Fedorova. 2018. Physicochemical and functional properties of Cucurbita maxima pumpkin pectin and commercial citrus and apple pectins: A comparative evaluation. PloS One 13 (9):e0204261. doi: 10.1371/journal.pone.0204261.
   PubMed Web of Science ®Google Scholar
• Van den Abbeele, P., L. Verstrepen, J. Ghyselinck, R. Albers, M. Marzorati, and A. Mercenier. 2020. A novel non-digestible, carrot-derived polysaccharide (cRG-I) selectively modulates the human gut microbiota while promoting gut barrier integrity: An integrated in vitro approach. Nutrients 12 (7):1917. doi: 10.3390/nu12071917.
   PubMed Web of Science ®Google Scholar
• Verkempinck, S., L. Salvia-Trujillo, S. Denis, A. Van Loey, M. Hendrickx, and T. Grauwet. 2018. Pectin influences the kinetics of in vitro lipid digestion in oil-in-water emulsions. Food Chemistry 262:150–61. doi: 10.1016/j.foodchem.2018.04.082.
   PubMedGoogle Scholar
• Villa-Rivera, M., H. Cano-Camacho, E. López-Romero, and M. Zavala-Páramo. 2021. The role of arabinogalactan type II degradation in plant-microbe interactions. Frontiers in Microbiology 12:730543. doi: 10.3389/fmicb.2021.730543.
   PubMedGoogle Scholar
• Vincken, J., H. Schols, R. Oomen, M. McCann, P. Ulvskov, A. Voragen, and R. Visser. 2003. If homogalacturonan were a side chain of rhamnogalacturonan I. Implications for cell wall architecture. Plant Physiology 132 (4):1781–9. doi: 10.1104/pp.103.022350.
   PubMed Web of Science ®Google Scholar
• Vogt, L. M., D. Meyer, G. Pullens, M. M. Faas, K. Venema, U. Ramasamy, H. A. Schols, and P. de Vos. 2014. Toll-like receptor 2 activation by β2→ 1-fructans protects barrier function of T84 human intestinal epithelial cells in a chain length–dependent manner. The Journal of Nutrition 144 (7):1002–8. doi: 10.3945/jn.114.191643.
   PubMed Web of Science ®Google Scholar
• Vogt, L. M., N. M. Sahasrabudhe, U. Ramasamy, D. Meyer, G. Pullens, M. M. Faas, K. Venema, H. A. Schols, and P. de Vos. 2016. The impact of lemon pectin characteristics on TLR activation and T84 intestinal epithelial cell barrier function. Journal of Functional Foods 22:398–407. doi: 10.1016/j.jff.2016.02.002.
   Web of Science ®Google Scholar
• Voragen, A., G. Coenen, R. Verhoef, and H. Schols. 2009. Pectin, a versatile polysaccharide present in plant cell walls. Structural Chemistry 20 (2):263–75. doi: 10.1007/s11224-009-9442-z.
   Web of Science ®Google Scholar
• Wang, W., C. Li, C. Chen, X. Fu, and R. Liu. 2022. Effect of chitosan oligosaccharide glycosylation on the emulsifying property of lactoferrin. International Journal of Biological Macromolecules 209 (Pt A):93–106. doi: 10.1016/j.ijbiomac.2022.03.169.
   PubMedGoogle Scholar
• Wang, W., W. Chen, M. Zou, R. Lv, D. Wang, F. Hou, H. Feng, X. Ma, J. Zhong, T. Ding, et al. 2018. Applications of power ultrasound in oriented modification and degradation of pectin: A review. Journal of Food Engineering 234:98–107. doi: 10.1016/j.jfoodeng.2018.04.016.
   Web of Science ®Google Scholar
• Wang, W., X. Ma, P. Jiang, L. Hu, Z. Zhi, J. Chen, T. Ding, X. Ye, and D. Liu. 2016. Characterization of pectin from grapefruit peel: A comparison of ultrasound-assisted and conventional heating extractions. Food Hydrocolloids. 61:730–9. doi: 10.1016/j.foodhyd.2016.06.019.
   Web of Science ®Google Scholar
• Wikiera, A., M. Grabacka, Ł. Byczyński, B. Stodolak, and M. Mika. 2021. Enzymatically extracted apple pectin possesses antioxidant and antitumor activity. Molecules 26 (5):1434. doi: 10.3390/molecules26051434.
   PubMed Web of Science ®Google Scholar
• Wikiera, A., M. Mika, A. Starzyńska-Janiszewska, and B. Stodolak. 2015. Application of Celluclast 1.5 L in apple pectin extraction. Carbohydrate Polymers 134:251–7. doi: 10.1016/j.carbpol.2015.07.051.
   PubMed Web of Science ®Google Scholar
• Wikiera, A., M. Mika, A. Starzyńska-Janiszewska, and B. Stodolak. 2016. Endo-xylanase and endo-cellulase-assisted extraction of pectin from apple pomace. Carbohydrate Polymers 142:199–205. doi: 10.1016/j.carbpol.2016.01.063.
   PubMed Web of Science ®Google Scholar
• Williams, P. A., C. Sayers, C. Viebke, C. Senan, J. Mazoyer, and P. Boulenguer. 2005. Elucidation of the emulsification properties of sugar beet pectin. Journal of Agricultural and Food Chemistry 53 (9):3592–7. doi: 10.1021/jf0404142.
   PubMed Web of Science ®Google Scholar
• Wu, D., J. Zheng, G. Mao, W. Hu, X. Ye, R. Linhardt, and S. Chen. 2020. Rethinking the impact of RG-I mainly from fruits and vegetables on dietary health. Critical Reviews in Food Science and Nutrition 60 (17):2938–60. doi: 10.1080/10408398.2019.1672037.
   PubMed Web of Science ®Google Scholar
• Wu, D., J. Zheng, W. Hu, X. Zheng, Q. He, R. J. Linhardt, X. Ye, and S. Chen. 2020. Structure-activity relationship of citrus segment membrane RG-I pectin against Galectin-3: The galactan is not the only important factor. Carbohydrate Polymers 245:116526. doi: 10.1016/j.carbpol.2020.116526.
   PubMed Web of Science ®Google Scholar
• Wu, D., X. Ye, R. J. Linhardt, X. Liu, K. Zhu, C. Yu, T. Ding, D. Liu, Q. He, and S. Chen. 2021. Dietary pectic substances enhance gut health by its polycomponent: A review. Comprehensive Reviews in Food Science and Food Safety 20 (2):2015–39. doi: 10.1111/1541-4337.12723.
   PubMed Web of Science ®Google Scholar
• Wu, D., X. Zheng, W. Hu, K. Zhu, C. Yu, Q. He, R. J. Linhardt, X. Ye, and S. Chen. 2021. Anti-inflammation effects of highly purified low-Mw RG-I pectins on LPS-activated macrophages. Bioactive Carbohydrates and Dietary Fibre 26:100283. doi: 10.1016/j.bcdf.2021.100283.
   Google Scholar
• Wu, D., Y. He, Q. Yuan, S. Wang, R. Gan, Y. Hu, and L. Zou. 2022. Effects of molecular weight and degree of branching on microbial fermentation characteristics of okra pectic-polysaccharide and its selective impact on gut microbial composition. Food Hydrocolloids 132:107897. doi: 10.1016/j.foodhyd.2022.107897.
   Google Scholar
• Wu, Q., C. Zheng, Z. Ning, and B. Yang. 2007. Modification of low molecular weight polysaccharides from Tremella fuciformis and their antioxidant activity in vitro. International Journal of Molecular Sciences 8 (7):670–9. doi: 10.3390/i8070670.
   Google Scholar
• Xu, H., K. Tai, T. Wei, F. Yuan, and Y. Gao. 2017. Physicochemical and in vitro antioxidant properties of pectin extracted from hot pepper (Capsicum annuum L. var. acuminatum (Fingerh.)) residues with hydrochloric and sulfuric acids. Journal of the Science of Food and Agriculture 97 (14):4953–60. doi: 10.1002/jsfa.8372.
   PubMed Web of Science ®Google Scholar
• Yang, J., T. Mu, and M. Ma. 2018. Extraction, structure, and emulsifying properties of pectin from potato pulp. Food Chemistry 244:197–205. doi: 10.1016/j.foodchem.2017.10.059.
   PubMed Web of Science ®Google Scholar
• Yang, X., Y. Zhao, and Y. Lv. 2007. Chemical composition and antioxidant activity of an acidic polysaccharide extracted from Cucurbita moschata Duchesne ex Poiret. Journal of Agricultural and Food Chemistry 55 (12):4684–90. doi: 10.1021/jf070241r.
   PubMedGoogle Scholar
• Yao, Y., J. Yao, Z. Du, P. Wang, and K. Ding. 2018. Structural elucidation and immune-enhancing activity of an arabinogalactan from flowers of Carthamus tinctorius L. Carbohydrate Polymers 202:134–42. doi: 10.1016/j.carbpol.2018.08.098.
   PubMed Web of Science ®Google Scholar
• Yapo, B. M. 2011a. Rhamnogalacturonan-I: A structurally puzzling and functionally versatile polysaccharide from plant cell walls and mucilages. Polymer Reviews 51 (4):391–413. doi: 10.1080/15583724.2011.615962.
   Web of Science ®Google Scholar
• Yapo, B. M. 2011b. Pectic substances: From simple pectic polysaccharides to complex pectins—A new hypothetical model. Carbohydrate Polymers 86 (2):373–85. doi: 10.1016/j.carbpol.2011.05.065.
   Web of Science ®Google Scholar
• Yapo, B. M. 2011c. Pectin rhamnogalacturonan II: On the “Small Stem with Four Branches” in the primary cell walls of plants. International Journal of Carbohydrate Chemistry 2011:1–11. doi: 10.1155/2011/964521.
   Google Scholar
• Yapo, B. M., and K. L. Koffi. 2013. Utilisation of model pectins reveals the effect of demethylated block size frequency on calcium gel formation. Carbohydrate Polymers 92 (1):1–10. doi: 10.1016/j.carbpol.2012.09.010.
   PubMedGoogle Scholar
• Yin, X., Y. Zheng, X. Kong, S. Cao, S. Chen, D. Liu, X. Ye, and J. Tian. 2021. RG-І pectin affects the physicochemical properties and digestibility of potato starch. Food Hydrocolloids 117:106687. doi: 10.1016/j.foodhyd.2021.106687.
   Web of Science ®Google Scholar
• Yu, C., S. Ahmadi, S. Shen, D. Wu, H. Xiao, T. Ding, D. Liu, X. Ye, and S. Chen. 2022. Structure and fermentation characteristics of five polysaccharides sequentially extracted from sugar beet pulp by different methods. Food Hydrocolloids. 126:107462. doi: 10.1016/j.foodhyd.2021.107462.
   Google Scholar
• Yu, L., X. Zhang, S. Li, X. Liu, L. Sun, H. Liu, J. Iteku, Y. Zhou, and G. Tai. 2010. Rhamnogalacturonan I domains from ginseng pectin. Carbohydrate Polymers 79 (4):811–7. doi: 10.1016/j.carbpol.2009.08.028.
   Web of Science ®Google Scholar
• Zaidel, D., and A. Meyer. 2012. Biocatalytic cross-linking of pectic polysaccharides for designed food functionality: Structures, mechanisms, and reactions. Biocatalysis and Agricultural Biotechnology 1 (3):207–19. doi: 10.1016/j.bcab.2012.03.007.
   Google Scholar
• Zdunek, A., P. Pieczywek, and J. Cybulska. 2021. The primary, secondary, and structures of higher levels of pectin polysaccharides. Comprehensive Reviews in Food Science and Food Safety 20 (1):1101–17. doi: 10.1111/1541-4337.12689.
   PubMed Web of Science ®Google Scholar
• Zhang, H., J. Chen, J. Li, L. Yan, S. Li, X. Ye, D. Liu, T. Ding, R. J. Linhardt, C. Orfila, et al. 2018. Extraction and characterization of RG-I enriched pectic polysaccharides from mandarin citrus peel. Food Hydrocolloids 79:579–86. doi: 10.1016/j.foodhyd.2017.12.002.
   Web of Science ®Google Scholar
• Zhang, L., J. Zheng, Y. Wang, X. Ye, S. Chen, H. Pan, and J. Chen. 2022. Fabrication of rhamnogalacturonan-I enriched pectin-based emulsion gels for protection and sustained release of curcumin. Food Hydrocolloids 128:107592. doi: 10.1016/j.foodhyd.2022.107592.
   Google Scholar
• Zhang, M., H. Zu, X. Zhuang, Y. Yu, Y. Wang, Z. Zhao, and Y. Zhou. 2020. Structural analyses of the HG-type pectin from Notopterygium incisum and its effects on galectins. International Journal of Biological Macromolecules 162:1035–43. doi: 10.1016/j.ijbiomac.2020.06.216.
   PubMedGoogle Scholar
• Zhang, S., G. I. Waterhouse, F. Xu, Z. He, Y. Du, Y. Lian, D. Wu, and D. Sun-Waterhouse. 2021. Recent advances in utilization of pectins in biomedical applications: A review focusing on molecular structure-directing health-promoting properties. Critical Reviews in Food Science and Nutrition :1–34. doi: 10.1080/10408398.2021.1988897.
   Google Scholar
• Zhang, S., Z. He, Y. Cheng, F. Xu, X. Cheng, and P. Wu. 2021. Physicochemical characterization and emulsifying properties evaluation of RG-I enriched pectic polysaccharides from Cerasus humilis. Carbohydrate Polymers 260:117824. doi: 10.1016/j.carbpol.2021.117824.
   PubMed Web of Science ®Google Scholar
• Zhang, T., M. Shuai, P. Ma, J. Huang, C. Sun, X. Yao, Z. Chen, X. Min, and S. Yan. 2020. Purification, chemical analysis and antioxidative activity of polysaccharides from pH-modified citrus pectin after dialyzation. LWT 128:109513. doi: 10.1016/j.lwt.2020.109513.
   Google Scholar
• Zhang, T., Y. Lan, Y. Zheng, F. Liu, D. Zhao, K. H. Mayo, Y. Zhou, and G. Tai. 2016. Identification of the bioactive components from pH-modified citrus pectin and their inhibitory effects on galectin-3 function. Food Hydrocolloids 58:113–9. doi: 10.1016/j.foodhyd.2016.02.020.
   Web of Science ®Google Scholar
• Zhang, W., P. Xu, and H. Zhang. 2015. Pectin in cancer therapy: A review. Trends in Food Science & Technology 44 (2):258–71. doi: 10.1016/j.tifs.2015.04.001.
   Web of Science ®Google Scholar
• Zhang, X., L. Yu, H. Bi, X. Li, W. Ni, H. Han, N. Li, B. Wang, Y. Zhou, and G. Tai. 2009. Total fractionation and characterization of the water-soluble polysaccharides isolated from Panax ginseng CA Meyer. Carbohydrate Polymers 77 (3):544–52. doi: 10.1016/j.carbpol.2009.01.034.
   Web of Science ®Google Scholar
• Zhang, X., S. Li, L. Sun, L. Ji, J. Zhu, Y. Fan, G. Tai, and Y. Zhou. 2012. Further analysis of the structure and immunological activity of an RG-I type pectin from Panax ginseng. Carbohydrate Polymers 89 (2):519–25. doi: 10.1016/j.carbpol.2012.03.039.
   PubMed Web of Science ®Google Scholar
• Zhang, Z., X. Wang, X. Mo, and H. Qi. 2013. Degradation and the antioxidant activity of polysaccharide from Enteromorpha linza. Carbohydrate Polymers 92 (2):2084–7. doi: 10.1016/j.carbpol.2012.11.096.
   PubMed Web of Science ®Google Scholar
• Zhao, J., F. Zhang, X. Liu, K. Ange, A. Zhang, Q. Li, and R. Linhardt. 2017. Isolation of a lectin binding rhamnogalacturonan-I containing pectic polysaccharide from pumpkin. Carbohydrate Polymers 163:330–6. doi: 10.1016/j.carbpol.2017.01.067.
   PubMed Web of Science ®Google Scholar
• Zhao, Y., J. Bi, J. Yi, X. Wu, Y. Ma, and R. Li. 2021. Pectin and homogalacturonan with small molecular mass modulate microbial community and generate high SCFAs via in vitro gut fermentation. Carbohydrate Polymers 269:118326. doi: 10.1016/j.carbpol.2021.118326.
   PubMed Web of Science ®Google Scholar
• Zheng, J., J. Chen, H. Zhang, D. Wu, X. Ye, R. Linardt, and S. Chen. 2020. Gelling mechanism of RG-I enriched citrus pectin: Role of arabinose side-chains in cation-and acid-induced gelation. Food Hydrocolloids 101:105536. doi: 10.1016/j.foodhyd.2019.105536.
   Google Scholar
• Zhi, Z., J. Chen, S. Li, W. Wang, R. Huang, D. Liu, T. Ding, R. J. Linhardt, S. Chen, and X. Ye. 2017. Fast preparation of RG-I enriched ultra-low molecular weight pectin by an ultrasound accelerated Fenton process. Scientific Reports 7 (1):1–11. doi: 10.1038/s41598-017-00572-3.
   PubMedGoogle Scholar
• Zhou, Y., H. Niu, T. Luo, Y. Yun, M. Zhang, W. Chen, Q. Zhong, H. Zhang, H. Chen, and W. Chen. 2021. Effect of glycosylation with sugar beet pectin on the interfacial behaviour and emulsifying ability of coconut protein. International Journal of Biological Macromolecules 183:1621–9. doi: 10.1016/j.ijbiomac.2021.05.061.
   PubMed Web of Science ®Google Scholar
• Zhu, K., G. Mao, D. Wu, C. Yu, H. Cheng, H. Xiao, X. Ye, R. J. Linhardt, C. Orfila, and S. Chen. 2020. Highly branched RG-I domain enrichment is indispensable for pectin mitigating against high-fat diet-induced obesity. Journal of Agricultural and Food Chemistry 68 (32):8688–701. doi: 10.1021/acs.jafc.0c02654.
   PubMed Web of Science ®Google Scholar
• Zhu, M., R. Huang, P. Wen, Y. Song, B. He, J. Tan, H. Hao, and H. Wang. 2021. Structural characterization and immunological activity of pectin polysaccharide from kiwano (Cucumis metuliferus) peels. Carbohydrate Polymers 254:117371. doi: 10.1016/j.carbpol.2020.117371.
   PubMed Web of Science ®Google Scholar
• Zhu, R., C. Wang, L. Zhang, Y. Wang, G. Chen, J. Fan, Y. Jia, F. Yan, and C. Ning. 2019. Pectin oligosaccharides from fruit of Actinidia arguta: Structure-activity relationship of prebiotic and antiglycation potentials. Carbohydrate Polymers 217:90–7. doi: 10.1016/j.carbpol.2019.04.032.
   PubMed Web of Science ®Google Scholar
• Zou, Y.-F., Y.-Y. Zhang, B. S. Paulsen, F. Rise, Z.-L. Chen, R.-Y. Jia, L.-X. Li, X. Song, B. Feng, H.-Q. Tang, et al. 2020. Structural features of pectic polysaccharides from stems of two species of Radix Codonopsis and their antioxidant activities. International Journal of Biological Macromolecules 159:704–13. doi: 10.1016/j.ijbiomac.2020.05.083.
   PubMed Web of Science ®Google Scholar
• Zu, Y., L. Zhao, L. Hao, Y. Mechref, M. Zabet-Moghaddam, P. A. Keyel, M. Abbasi, D. Wu, J. A. Dawson, R. Zhang, et al. 2021. Browning white adipose tissue using adipose stromal cell-targeted resveratrol-loaded nanoparticles for combating obesity. Journal of Controlled Release: Official Journal of the Controlled Release Society 333:339–51. doi: 10.1016/j.jconrel.2021.03.022.
   PubMedGoogle Scholar