Plant-derived polyphenolic compounds: nanodelivery through polysaccharide-based systems to improve the biological properties

References

• Adan, R. A. H., Beek, E. M. Van Der, Buitelaar, J. K. Cryan, J. F. Hebebrand, J. Higgs, S. Schellekens, H, and Dickson, S. L. 2019. Nutritional psychiatry : Towards improving mental health by what you eat. European Neuropsychopharmacology : The Journal of the European College of Neuropsychopharmacology 29 (12):1321–32. doi: 10.1016/j.euroneuro.2019.10.011.[Mismatch]
   PubMed Web of Science ®Google Scholar
• Adefegha, S. A., A. Salawi, A. Bumrungpert, S. Khorasani, M. R. Mozafari, and E. Taghavi. 2022. Encapsulation of polyphenolic compounds for health promotion and disease prevention: Challenges and opportunities. Nano Micro Biosystems 1 (2):1–12. doi: 10.22034/NMBJ.2023.163756
   Google Scholar
• Adrian, G., M. Mihai, and D. C. Vodnar. 2019. The use of chitosan, alginate, and pectin in the. Polymers 11:1837. doi: 10.3390/polym11111837
   PubMed Web of Science ®Google Scholar
• Afsharzadeh, M. Hashemi, and A. Mokhtarzadeh, Ramezani M. 2018. Recent advances in co-delivery systems based on polymeric nanoparticle for cancer treatment. Artificial Cells Nanomedicine Biotechnology 1401: 1095–1110. doi: 10.1080/21691401.2017.1376675.
   Google Scholar
• Ahirrao, S. P., P. S. Gide, B. Shrivastav, and P. Sharma. 2014. Ionotropic gelation: A promising cross linking technique for hydrogels. Research and Reviews: Journal of Pharmaceutics and Nanotechnology 2 (1):1–6.
   Google Scholar
• Ahmad, M., P. Mudgil, A. Gani, F. Hamed, F. A. Masoodi, and S. Maqsood. 2019. Nano-encapsulation of catechin in starch nanoparticles : Characterization, release behavior and bioactivity retention during simulated in-vitro digestion. Food Chemistry 270 (July 2018):95–104. doi: 10.1016/j.foodchem.2018.07.024.
   PubMedGoogle Scholar
• Akbari-Alavijeh, S., R. Shaddel, and S. M. Jafari. 2020. Encapsulation of food bioactives and nutraceuticals by various chitosan-based nanocarriers. Food Hydrocolloids. 105 (November 2019):105774. doi: 10.1016/j.foodhyd.2020.105774.
   Google Scholar
• Akhavan, S., E. Assadpour, I. Katouzian, and S. M. Jafari. 2018. Lipid nano scale cargos for the protection and delivery of food bioactive ingredients and nutraceuticals. Trends in Food Science & Technology 74 (February):132–46. doi: 10.1016/j.tifs.2018.02.001.
   Google Scholar
• Andersen, T., P. Auk-Emblem, and M. Dornish. 2015. 3D cell culture in alginate hydrogels. Microarrays (Basel, Switzerland) 4 (2):133–61. doi: 10.3390/microarrays4020133.
   PubMedGoogle Scholar
• Andishmand, H., S. Azadmard-Damirchi, H. Hamishekar, M. Torbati, M. Saeed, G. P. Savage, C. Tan, and S. Mahdi. 2023. Nano-delivery systems for encapsulation of phenolic compounds from pomegranate peel 311 (January): 10283–102847
   Google Scholar
• Antonov, Y. A., M. Celus, C. Kyomugasho, M. Hendrickx, P. Moldenaers, and R. Cardinaels. 2019. Complexation of pectins varying in overall charge with lysozyme in aqueous buffered solutions. Food Hydrocolloids. 94 (October 2018):268–78. doi: 10.1016/j.foodhyd.2019.02.049.
   Google Scholar
• Antonov, Y. A., I. L. Zhuravleva, M. Celus, C. Kyomugasho, M. Hendrickx, P. Moldenaers, and R. Cardinaels. 2022. Effect of overall charge and local charge density of pectin on the structure and thermal stability of lysozyme. Journal of Thermal Analysis and Calorimetry 147 (11):6271–86. doi: 10.1007/s10973-021-10954-5.
   Web of Science ®Google Scholar
• Arroyo-Maya, I. J., and D. J. McClements. 2015. Biopolymer nanoparticles as potential delivery systems for anthocyanins: Fabrication and properties. Food Research International 69:1–8. doi: 10.1016/j.foodres.2014.12.005.
   Web of Science ®Google Scholar
• Ashley, D., D. Marasini, C. Brownmiller, J. A. Lee, F. Carbonero, and S. Lee. 2019. Impact of grain sorghum polyphenols on microbiota of normal weight and overweight/obese subjects during in vitro fecal fermentation. Nutrients (11): 217. doi: 10.3390/nu11020217.
   Google Scholar
• Assadpour, E., and S. M. Jafari. 2019. A systematic review on nanoencapsulation of food bioactive ingredients and nutraceuticals by various nanocarriers. Critical Reviews in Food Science and Nutrition 59 (19):3129–51. doi: 10.1080/10408398.2018.1484687.
   PubMed Web of Science ®Google Scholar
• Ayala-Fuentes, J. C., and R. A. Chavez-Santoscoy. 2021. Nanotechnology as a key to enhance the benefits and improve the bioavailability of flavonoids in the food industry. Foods 10 (11):2701. doi: 10.3390/foods10112701.
   Google Scholar
• Bai, Y., Z. Zhang, A. Zhang, L. Chen, C. He, X. Zhuang, and X. Chen. 2012. Novel thermo- and pH-responsive hydroxypropyl cellulose- and poly (l-glutamic acid)-based microgels for oral insulin controlled release. Carbohydrate Polymers 89 (4):1207–14. doi: 10.1016/j.carbpol.2012.03.095.
   PubMed Web of Science ®Google Scholar
• Bajpai, V. K., M. Kamle, S. Shukla, D. Kumar, P. Chandra, S. Kyu, P. Kumar, Y. Suk, and Y. Han. 2018. Prospects of using nanotechnology for food preservation, safety, and security. Journal of Food and Drugs Analysis 26:1201–1214. doi: 10.1016/j.jfda.2018.06.011.
   Google Scholar
• Baliyan, N., R. Rani, P. Kaur, Y. K. Yadava, and L. Kumar. 2020. Nanoencapsulation development for interactive foods. Chemical Science Review and Letters 9 (36):1039–57. doi: 10.37273/chesci.CS205107155.
   Google Scholar
• Ban, E., and A. Kim. 2022. Coacervates : Recent developments as nanostructure delivery platforms for therapeutic biomolecules. International Journal of Pharmaceutics 624 (July):122058. doi: 10.1016/j.ijpharm.2022.122058.
   PubMedGoogle Scholar
• Bao, C., P. Jiang, J. Chai, Y. Jiang, D. Li, W. Bao, B. Liu, B. Liu, W. Norde, and Y. Li. 2019. The delivery of sensitive food bioactive ingredients: Absorption mechanisms, influencing factors, encapsulation techniques and evaluation models. Food Research International (Ottawa, Ont.) 120 (September 2018):130–40. doi: 10.1016/j.foodres.2019.02.024.
   PubMedGoogle Scholar
• Bauer, S. 2012. Mass spectrometry for characterizing plant cell wall polysaccharides. Frontiers in Plant Science 3 (Mar):45. doi: 10.3389/fpls.2012.00045.
   PubMedGoogle Scholar
• Bealer, E. J., S. Onissema-Karimu, A. Rivera-Galletti, M. Francis, J. Wilkowski, and X. Hu. 2020. Protein – Polysaccharide composite materials.  Polymers 12:464. doi: 10.3390/polym12020464.
   PubMed Web of Science ®Google Scholar
• Besford, Q. A., F. Cavalieri, and F. Caruso. 2020. Glycogen as a building block for advanced biological materials. Advanced Materials (Deerfield Beach, Fla.) 32 (18): E 1904625. doi: 10.1002/adma.201904625.
   Web of Science ®Google Scholar
• Bié, J., B. Sepodes, P. C. B. Fernandes, and M. H. L. Ribeiro. 2023. Polyphenols in health and disease: Gut microbiota, bioaccessibility, and bioavailability. Compounds 3 (1):40–72. doi: 10.3390/compounds3010005.
   Google Scholar
• Borges, V., V. Maciel, C. M. P. Yoshida, and T. Teixeira. 2015. Chitosan/pectin polyelectrolyte complex as a pH indicator. Carbohydrate Polymers 132:537–45. doi: 10.1016/j.carbpol.2015.06.047.
   PubMed Web of Science ®Google Scholar
• Braga, A. R. C., D. C. Murador, L. M. de Souza Mesquita, and V. V. de Rosso. 2018. Bioavailability of anthocyanins: Gaps in knowledge, challenges and future research. Journal of Food Composition and Analysis 68 (February 2017):31–40. doi: 10.1016/j.jfca.2017.07.031.
   Google Scholar
• Brodkorb, A., L. Egger, M. Alminger, P. Alvito, R. Assunção, S. Ballance, T. Bohn, C. Bourlieu-Lacanal, R. Boutrou, F. Carrière, et al. 2019. INFOGEST static in vitro simulation of gastrointestinal food digestion. Nature Protocols 14 (4):991–1014. doi: 10.1038/s41596-018-0119-1.
   PubMed Web of Science ®Google Scholar
• Bulatao, R. M., J. P. A. Samin, J. R. Salazar, and J. J. Monserate. 2017. Encapsulation of anthocyanins from black rice (Oryza sativa L.) bran extract using chitosan-alginate nanoparticles. Journal of Food Research 6 (3):40. doi: 10.5539/jfr.v6n3p40.
   Google Scholar
• Busato, B., E. Cristina, D. A. Abreu, C. Lucia, D. O. Petkowicz, G. R. Martinez, and G. R. Noleto. 2020. Pectin from Brassica oleracea var. italica triggers immunomodulating effects in vivo. International Journal of Biological Macromolecules 161:431–40. doi: 10.1016/j.ijbiomac.2020.06.051.
   PubMed Web of Science ®Google Scholar
• Caballero, S., Y. O. Li, D. J. Mcclements, and G. Davidov. 2022. Encapsulation and delivery of bioactive citrus pomace polyphenols : A review. Critical Reviews in Food Science and Nutrituin 62. doi: 10.1080/10408398.2021.1922873.
   Google Scholar
• Calvini, P., A. Gorassini, G. Luciano, and E. Franceschi. 2006. FTIR and WAXS analysis of periodate oxycellulose: Evidence for a cluster mechanism of oxidation. Vibrational Spectroscopy 40 (2):177–83. doi: 10.1016/j.vibspec.2005.08.004.
   Web of Science ®Google Scholar
• Câmara, J. S., B. R. Albuquerque, J. Aguiar, R. C. G. Corrêa, J. L. Gonçalves, D. Granato, J. A. M. Pereira, L. Barros, and I. C. F. R. Ferreira. 2020. Food bioactive compounds and emerging techniques for their extraction: Polyphenols as a case study. Foods 10 (1):37. doi: 10.3390/foods10010037.
   PubMed Web of Science ®Google Scholar
• Cao, N., X. Tang, R. J. Gao, L. Kong, J. Zhang, W. Qin, N. Hu, A. Zhang, K. Ma, L. Li, et al. 2021. Galectin-3 participates in PASMC migration and proliferation by interacting with TGF-β1. Life Sciences 274 (February):119347. doi: 10.1016/j.lfs.2021.119347.
   PubMedGoogle Scholar
• Cardona, F., C. Andrés-Lacueva, S. Tulipani, F. J. Tinahones, and M. I. Queipo-Ortuño. 2013. Benefits of polyphenols on gut microbiota and implications in human health. The Journal of Nutritional Biochemistry 24 (8):1415–22. doi: 10.1016/j.jnutbio.2013.05.001.
   PubMed Web of Science ®Google Scholar
• Carnauba, R. A., F. M. Sarti, N. M. A. Hassimotto, and F. M. Lajolo. 2022. Assessment of dietary intake of bioactive food compounds according to income level in the Brazilian population. The British Journal of Nutrition 127 (8):1232–9. doi: 10.1017/S0007114521001987.
   PubMed Web of Science ®Google Scholar
• Carrasco-Sandoval, J., M. Aranda-Bustos, K. Henríquez-Aedo, A. López-Rubio, and M. J. Fabra. 2021. Bioaccessibility of different types of phenolic compounds co-encapsulated in alginate/chitosan-coated zein nanoparticles. LWT 149 (June):112024. doi: 10.1016/j.lwt.2021.112024.
   Google Scholar
• Carvalho, R., S. D. Soares, M. G. Martins, C. Alves, J. Otávio, C. Silva, B. E. Teixeira-Costa, M. D. S. Figueira, and O. Vasconcelos. 2022. Bioactive, technological-functional potential and morphological structures of passion fruit albedo (Passiflora edulis). Food Science and Technology 42 2061:1–10 doi: 10.1590/fst.22222
   Google Scholar
• Chang, C., T. Wang, Q. Hu, and Y. Luo. 2017. Zein/caseinate/pectin complex nanoparticles: Formation and characterization. International Journal of Biological Macromolecules 104 (Pt A):117–24. doi: 10.1016/j.ijbiomac.2017.05.178.
   PubMedGoogle Scholar
• Chatterjee, N. S., P. K. Dara, S. Perumcherry Raman, D. K. Vijayan, J. Sadasivam, S. Mathew, C. N. Ravishankar, and R. Anandan. 2021. Nanoencapsulation in low-molecular-weight chitosan improves in vivo antioxidant potential of black carrot anthocyanin. Journal of the Science of Food and Agriculture 101 (12):5264–71. doi: 10.1002/jsfa.11175.
   PubMed Web of Science ®Google Scholar
• Chen, C., Z. Li, C. Wang, S. Liu, Y. Wang, M. Zhang, Y. Tian, J. Lv, H. Xu, and G. Xia. 2023. Stability and antioxidant activity of chitosan/β-Lactoglobulin on anthocyanins from Aronia melanocarpa. LWT 173:114335. doi: 10.1016/j.lwt.2022.114335.
   Web of Science ®Google Scholar
• Chen, Y., Q. Li, T. Zhao, Z. Zhang, G. Mao, W. Feng, X. Wu, and L. Yang. 2017. Biotransformation and metabolism of three mulberry anthocyanin monomers by rat gut microflora. Food Chemistry 237:887–94. doi: 10.1016/j.foodchem.2017.06.054.
   PubMed Web of Science ®Google Scholar
• Chen, S., D. J. McClements, L. Jian, Y. Han, L. Dai, L. Mao, and Y. Gao. 2019. Core-shell biopolymer nanoparticles for co-delivery of curcumin and piperine: Sequential electrostatic deposition of hyaluronic acid and chitosan shells on the zein core. ACS Applied Materials & Interfaces 11 (41):38103–15. doi: 10.1021/acsami.9b11782.
   PubMed Web of Science ®Google Scholar
• Chi, J., J. Ge, X. Yue, J. Liang, Y. Sun, X. Gao, and P. Yue. 2019. Preparation of nanoliposomal carriers to improve the stability of anthocyanins. LWT 109 (December 2018):101–7. doi: 10.1016/j.lwt.2019.03.070.
   Google Scholar
• Cialdella-Kam, L., S. G. Id, M. P. Meaney, A. M. Knab, R. A. S. Id, and D. C. Nieman. 2017. Quercetin and green tea extract supplementation downregulates genes related to tissue inflammatory responses to a 12-week high fat-diet in mice. Nutrients: 773. doi: 10.3390/nu9070773.
   Google Scholar
• Comunian, T. A., M. P. Silva, and C. J. F. Souza. 2021. The use of food by-products as a novel for functional foods: Their use as ingredients and for the encapsulation process. Trends in Food Science & Technology 108 (January):269–80. doi: 10.1016/j.tifs.2021.01.003.
   Google Scholar
• Cordeiro, A. S., Y. Farsakoglu, J. Crecente, C. María, D. Fuente, and S. F. González. 2021. Carboxymethyl ‑ β ‑ glucan/chitosan nanoparticles : New thermostable and efficient carriers for antigen delivery. Drug Delivery and Translational Research 11 (4):1689–702. doi: 10.1007/s13346-021-00968-9.
   PubMed Web of Science ®Google Scholar
• Cory, H., S. Passarelli, J. Szeto, M. Tamez, and J. Mattei. 2018. The role of polyphenols in human health and food systems: A mini-review. Frontiers in Nutrition 5 (September):87. doi: 10.3389/fnut.2018.00087.
   PubMedGoogle Scholar
• Cosme, P., A. B. Rodríguez, and J. G. M. Espino. 2020. Plant phenolics: Bioavailability as a key determinant of their potential health-promoting applications. Antioxidants 9: 1263. doi:10.3390/antiox9121263
   Google Scholar
• Curtis, P. J., V. Van Der Velpen, L. Berends, A. Jennings, M. Feelisch, A. M. Umpleby, M. Evans, B. O. Fernandez, M. S. Meiss, M. Minnion, et al. 2019. Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial. The American Journal of Clinical Nutrition 109 (6):1535–45. doi: 10.1093/ajcn/nqy380.
   PubMed Web of Science ®Google Scholar
• Dacoba, T. G., R. W. Omange, H. Li, J. Crecente-Campo, M. Luo, and M. J. Alonso. 2019. Polysaccharide nanoparticles can efficiently modulate the immune response against an HIV peptide antigen. ACS Nano 13 (5):4947–59. doi: 10.1021/acsnano.8b07662.
   PubMed Web of Science ®Google Scholar
• De Ferrars, R. M., C. Czank, Q. Zhang, N. P. Botting, P. A. Kroon, A. Cassidy, and C. D. Kay. 2014. The pharmacokinetics of anthocyanins and their metabolites in humans. British Journal of Pharmacology 171 (13):3268–82. doi: 10.1111/bph.12676.
   PubMed Web of Science ®Google Scholar
• Dias, R., C. B. Pereira, P. Rosa, N. Mateus, and V. Freitas. 2021. Recent advances on dietary polyphenol’s potential roles in Celiac Disease. Trends in Food Science & Technology 107 (October 2020):213–25. doi: 10.1016/j.tifs.2020.10.033.
   Google Scholar
• Dima, C., E. Assadpour, S. Dima, and S. M. Jafari. 2020a. Bioactive-loaded nanocarriers for functional foods: From designing to bioavailability. Current Opinion in Food Science 33:21–9. doi: 10.1016/j.cofs.2019.11.006.
   Web of Science ®Google Scholar
• Dima, C., E. Assadpour, S. Dima, and S. M. Jafari. 2020b. Bioavailability and bioaccessibility of food bioactive compounds; overview and assessment by in vitro methods. Comprehensive Reviews in Food Science and Food Safety 19 (6):2862–84. doi: 10.1111/1541-4337.12623.
   PubMed Web of Science ®Google Scholar
• Dobrzynska, M., M. Napierala, and E. Florek. 2020. Flavonoid nanoparticles: A promising approach for cancer therapy. Biomolecules 10 (9):1–17. doi: 10.3390/biom10091268.
   Web of Science ®Google Scholar
• Dobson, C. C., W. Mottawea, A. Rodrigue, B. L. Buzati Pereira, R. Hammami, K. A. Power, and N. Bordenave. 2019. Impact of molecular interactions with phenolic compounds on food polysaccharides functionality. In Advances in food and nutrition research. 1st ed., vol. 90: 135–168. Elsevier Inc. ISSN 1043-4526. doi: 10.1016/bs.afnr.2019.02.010.
   Google Scholar
• Dogan Ergin, A., Z. S. Bayindir, A. T. Ozcelikay, and N. Yuksel. 2021. A novel delivery system for enhancing bioavailability of S-adenosyl-L-methionine: Pectin nanoparticles-in-microparticles and their in vitro - in vivo evaluation. Journal of Drug Delivery Science and Technology 61 (September 2020):102096. doi: 10.1016/j.jddst.2020.102096.
   Google Scholar
• Duda-Chodak, A., T. Tarko, P. Satora, and P. Sroka. 2015. Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: A review. European Journal of Nutrition 54 (3):325–41. doi: 10.1007/s00394-015-0852-y.
   PubMed Web of Science ®Google Scholar
• Dushkin, A. V., T. G. Tolstikova, M. V. Khvostov, and G. A. Tolstikov. 2012. Complexes of polysaccharides and glycyrrhizic acid with drug molecules − Mechanochemical synthesis and pharmacological activity. Ed.; IntechOpen: Rijeka, Croatia, 2012; pp. 573–602.
   Google Scholar
• Enaru, B., G. Drețcanu, T. D. Pop, A. Stǎnilǎ, and Z. Diaconeasa. 2021. Anthocyanins: Factors affecting their stability and degradation. Antioxidants 10 (12):1967. doi: 10.3390/antiox10121967.
   Web of Science ®Google Scholar
• Escobar-Puentes, A. A., A. García-Gurrola, S. Rincón, A. Zepeda, and F. Martínez-Bustos. 2020. Effect of amylose/amylopectin content and succinylation on properties of corn starch nanoparticles as encapsulants of anthocyanins. Carbohydrate Polymers 250 (July):116972. doi: 10.1016/j.carbpol.2020.116972.
   PubMedGoogle Scholar
• Estruel-Amades, S., M. Massot-Cladera, J. P. Francisco, and À. Franch. 2019. Hesperidin effects on gut microbiota and gut-associated lymphoid tissue in healthy rats. Nutrients 2019, 11, 324. doi: 10.3390/nu11020324.
   Google Scholar
• Ezhilarasi, P. N., P. Karthik, N. Chhanwal, and C. Anandharamakrishnan. 2013. Nanoencapsulation techniques for food bioactive components: A review. Food and Bioprocess Technology 6 (3):628–47. doi: 10.1007/s11947-012-0944-0.
   Web of Science ®Google Scholar
• Faria, A., I. Fernandes, S. Norberto, N. Mateus, and C. Calhau. 2014. Interplay between anthocyanins and gut microbiota. Journal of Agricultural and Food Chemistry 62 (29):6898–902. doi: 10.1021/jf501808a.
   PubMed Web of Science ®Google Scholar
• Faridi Esfanjani, A., E. Assadpour, and S. M. Jafari. 2018. Improving the bioavailability of phenolic compounds by loading them within lipid-based nanocarriers. Trends in Food Science & Technology 76 (April):56–66. doi: 10.1016/j.tifs.2018.04.002.
   Google Scholar
• Faridi, A., and S. M. Jafari. 2016. Biopolymer nano-particles and natural nano-carriers for nano-encapsulation of phenolic compounds. Colloids Surf B Biointerfaces 146:532–43 doi: 10.1016/j.colsurfb.2016.06.053.
   Google Scholar
• Fathi, M., Á. Martín, and D. J. McClements. 2014. Nanoencapsulation of food ingredients using carbohydrate based delivery systems. Trends in Food Science & Technology 39 (1):18–39. doi: 10.1016/j.tifs.2014.06.007.
   Web of Science ®Google Scholar
• Feng, J., Y. Wu, L. Zhang, Y. Li, S. Liu, H. Wang, and C. Li. 2019. Enhanced chemical stability, intestinal absorption, and intracellular antioxidant activity of cyanidin-3- o-glucoside by composite nanogel encapsulation. Journal of Agricultural and Food Chemistry 67 (37):10432–47. doi: 10.1021/acs.jafc.9b04778.
   PubMed Web of Science ®Google Scholar
• Fernandes, I., A. Faria, V. de Freitas, C. Calhau, and N. Mateus. 2015. Multiple-approach studies to assess anthocyanin bioavailability. Phytochemistry Reviews 14 (6):899–919. doi: 10.1007/s11101-015-9415-3.
   Web of Science ®Google Scholar
• Fernandes, A., N. Mateus, and V. Freitas. 2023. Polyphenol-dietary fiber conjugates from fruits and vegetables: Nature and biological fate in a food and nutrition perspective. Foods 12: 1052. doi: 10.3390/foods12051052
   Google Scholar
• Fernandes, A., J. Oliveira, F. Fonseca, F. Ferreira-da-Silva, N. Mateus, J. P. Vincken, and V. de Freitas. 2020. Molecular binding between anthocyanins and pectic polysaccharides – Unveiling the role of pectic polysaccharides structure. Food Hydrocolloids. 102 (December 2019):105625. doi: 10.1016/j.foodhyd.2019.105625.
   Google Scholar
• Fernández, J., S. Redondo-Blanco, E. M. Miguélez, C. J. Villar, A. Clemente, and F. Lombó. 2015. Healthy effects of prebiotics and their metabolites against intestinal diseases and colorectal cancer. AIMS Microbiology 1 (1):48–71. doi: 10.3934/microbiol.2015.1.48.
   Google Scholar
• Fisher, A., M. Watling, A. Smith, and A. Knight. 2010. Pharmacokinetics and relative bioavailability of fentanyl pectin nasal spray 100–800 µg in healthy volunteers. International Journal of Clinical Pharmacology and Therapeutics 48 (12):860–7. doi: 10.5414/cpp48860.
   PubMed Web of Science ®Google Scholar
• Fleschhut, J., F. Kratzer, G. Rechkemmer, and S. E. Kulling. 2006. Stability and biotransformation of various dietary anthocyanins in vitro. European Journal of Nutrition 45 (1):7–18. doi: 10.1007/s00394-005-0557-8.
   PubMed Web of Science ®Google Scholar
• Focsan, A. L., and N. E. Polyakov. 2019. Supramolecular carotenoid complexes of enhanced solubility and stability—The way of bioavailability improvement. Molecules 24: 3947. doi: 10.3390/molecules24213947
   Google Scholar
• Fraga, C. G., K. D. Croft, D. O. Kennedy, and F. A. Tomás-Barberán. 2019. The effects of polyphenols and other bioactives on human health. Food & Function 10 (2):514–28. doi: 10.1039/c8fo01997e.
   PubMed Web of Science ®Google Scholar
• Frosi, I., L. Ferron, R. Colombo, and A. Papetti. 2022. Natural carriers: Recent advances in their use to improve the stability and bioaccessibility of food active compounds. Critical Reviews in Food Science and Nutrition 19 :1–19. doi: 10.1080/10408398.2022.2157371.
   PubMed Web of Science ®Google Scholar
• Gaber Ahmed, G. H., A. Fernández-González, and M. E. Díaz García. 2020. Nano-encapsulation of grape and apple pomace phenolic extract in chitosan and soy protein via nanoemulsification. Food Hydrocolloids. 108 (May 2019):105806. doi: 10.1016/j.foodhyd.2020.105806.
   Google Scholar
• Garavand, F., M. Jalai-Jivan, E. Assadpour, and S. Mahdi. 2021. Encapsulation of phenolic compounds within nano/microemulsion systems: A review. Food Chemistry 364 (April):130376. doi: 10.1016/j.foodchem.2021.130376.
   PubMedGoogle Scholar
• Garg, U., S. Chauhan, U. Nagaich, and N. Jain. 2019. Current advances in chitosan nanoparticles based drug delivery and targeting. Tabriz University of Medical Sciences 7 (3):113–7. doi: 10.15171/jcvtr.2015.24.
   Google Scholar
• Ge, J., X. Yue, S. Wang, J. Chi, J. Liang, Y. Sun, X. Gao, and P. Yue. 2019. Nanocomplexes composed of chitosan derivatives and β-lactoglobulin as a carrier for anthocyanins: Preparation, stability and bioavailability in vitro. Food Research International (Ottawa, Ont.) 116:336–45. doi: 10.1016/j.foodres.2018.08.045.
   PubMed Web of Science ®Google Scholar
• Gharibzahedi, S. M. T., F. J. Marti-Quijal, F. J. Barba, and Z. Altintas. 2022. Current emerging trends in antitumor activities of polysaccharides extracted by microwave- and ultrasound-assisted methods. International Journal of Biological Macromolecules 202 (January):494–507. doi: 10.1016/j.ijbiomac.2022.01.088.
   PubMedGoogle Scholar
• Gonçalves, A. C., G. Alves, A. Lopes, and R. Silva. 2022. Employ of anthocyanins in nanocarriers for nano delivery : In vitro and in vivo experimental approaches for chronic diseases. Pharmaceutics 14: 2272. doi: 10.3390/pharmaceutics14112272
   Google Scholar
• Gonçalves, R. F. S., J. T. Martins, C. M. M. Duarte, A. A. Vicente, and A. C. Pinheiro. 2018. Advances in nutraceutical delivery systems: From formulation design for bioavailability enhancement to efficacy and safety evaluation. Trends in Food Science & Technology 78 (June):270–91. doi: 10.1016/j.tifs.2018.06.011.
   Google Scholar
• Goodarzi, N., R. Varshochian, G. Kamalinia, F. Atyabi, and R. Dinarvand. 2013. A review of polysaccharide cytotoxic drug conjugates for cancer therapy. Carbohydrate Polymers 92 (2):1280–93. doi: 10.1016/j.carbpol.2012.10.036.
   PubMed Web of Science ®Google Scholar
• Gopi Krishna, P., S. Kameswaran, T. Sri Ranjani, and Y. Gunavathi. 2021. Recent developments in nanoencapsulation of bioactive compounds of microbial sources and their biomedical applications. In Recent developments in applied microbiology and biochemistry. Academic Press 2: 141–152. doi: 10.1016/b978-0-12-821406-0.00014-x.
   Google Scholar
• Gopinath, V., S. Saravanan, A. R. Al-Maleki, M. Ramesh, and J. Vadivelu. 2018. A review of natural polysaccharides for drug delivery applications: Special focus on cellulose, starch and glycogen. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 107 (July):96–108. doi: 10.1016/j.biopha.2018.07.136.
   PubMedGoogle Scholar
• Gottesmann, M., F. M. Goycoolea, T. Steinbacher, T. Menogni, and A. Hensel. 2020. Smart drug delivery against Helicobacter pylori: Pectin-coated, mucoadhesive liposomes with antiadhesive activity and antibiotic cargo. Applied Microbiology and Biotechnology 104 (13):5943–57. doi: 10.1007/s00253-020-10647-3.
   PubMed Web of Science ®Google Scholar
• Grgić, J., G. Šelo, M. Planinić, M. Tišma, and A. Bucić-Kojić. 2020. Role of the encapsulation in bioavailability of phenolic compounds. Antioxidants 9 (10):1–36. doi: 10.3390/antiox9100923.
   Web of Science ®Google Scholar
• Gu, J., J. M. Thomas-Ahner, K. M. Riedl, M. T. Bailey, Y. Vodovotz, S. J. Schwartz, and S. K. Clinton. 2019. Dietary black raspberries impact the colonic microbiome and phytochemical metabolites in mice. Molecular Nutrition & Food Research 63 (8):e1800636. doi: 10.1002/mnfr.201800636.
   PubMed Web of Science ®Google Scholar
• Guadarrama-Escobar, O. R., P. Serrano-Castañeda, E. Anguiano-Almaz, V. Alma, M. Concepci, R. Vera-Graziano, M. I. Morales-Florido, B. Rodriguez-Perez, I. M. Rodriguez-Cruz, J. Esteban, et al. 2023. Chitosan nanoparticles as oral drug carriers. International Journal of Molecular Sciences 24 :1–17. doi: 10.3390/ijms24054289
   Google Scholar
• Gummel, J., F. Boué, B. Demé, and F. Cousin. 2006. Charge stoichiometry inside polyelectrolyte-protein complexes: A direct SANS measurement for the PSSNa-lysozyme system. The Journal of Physical Chemistry. B 110 (49):24837–46. doi: 10.1021/jp064383k.
   PubMed Web of Science ®Google Scholar
• Hanhineva, K., R. Törrönen, I. Bondia-Pons, J. Pekkinen, M. Kolehmainen, H. Mykkänen, and K. Poutanen. 2010. Impact of dietary polyphenols on carbohydrate metabolism. International Journal of Molecular Sciences 11 (4):1365–402. doi: 10.3390/ijms11041365.
   PubMed Web of Science ®Google Scholar
• Hasanvand, E., M. Fathi, A. Bassiri, M. Javanmard, and R. Abbaszadeh. 2015. Novel starch based nanocarrier for vitamin D fortification of milk: Production and characterization. Food and Bioproducts Processing Novel Starch Based Nanocarrier for Vitamin D Fortification of Milk: Production and Characterization 96:264–77. doi: 10.1016/j.fbp.2015.09.007.
   Google Scholar
• Hassan, E., S. Fadel, W. Abou-Elseoud, and M. Mahmoud. 2022. Cellulose nanofibers/pectin/pomegranate extract nanocomposite as antibacterial and antioxidant films and coating for paper.
   Google Scholar
• He, Y., D. Chen, Y. Liu, X. Sun, W. Guo, L. An, Z. Shi, L. Wen, Z. Wang, and H. Yu. 2022. Protective effect and mechanism of soybean insoluble dietary fiber on the color stability of malvidin-3- O –glucoside. Foods 11: 1474. doi: 10.3390/foods11101474
   Google Scholar
• He, B., J. Ge, P. Yue, X. Y. Yue, R. Fu, J. Liang, and X. Gao. 2017. Loading of anthocyanins on chitosan nanoparticles influences anthocyanin degradation in gastrointestinal fluids and stability in a beverage. Food Chemistry 221:1671–7. doi: 10.1016/j.foodchem.2016.10.120.
   PubMed Web of Science ®Google Scholar
• Henriques, J. F., D. Serra, T. C. P. Dinis, and L. M. Almeida. 2020. The anti-neuroinflammatory role of anthocyanins and their metabolites for the prevention and treatment of brain disorders. Internacional Journal Molecular Science 21: 8653. doi:10.3390/ijms21228653
   Google Scholar
• Hidalgo, M., M. J. Oruna-Concha, S. Kolida, G. E. Walton, S. Kallithraka, J. P. E. Spencer, G. R. Gibson, and S. De Pascual-Teresa. 2012. Metabolism of anthocyanins by human gut microflora and their influence on gut bacterial growth. Journal of Agricultural and Food Chemistry 60 (15):3882–90. doi: 10.1021/jf3002153.
   PubMed Web of Science ®Google Scholar
• Horn, J., D. E. Mayer, S. Chen, and E. A. Mayer. 2022. Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders. Translational Psychiatry 12:164. doi: 10.1038/s41398-022-01922-0.
   Google Scholar
• Hossain, M. K., A. A. Dayem, J. Han, Y. Yin, K. Kim, S. K. Saha, G. Yang, H. Y. Choi, and S. Cho. 2016. Molecular mechanisms of the anti-obesity and anti-diabetic properties of flavonoids. International Journal of Molecular Sciences 17 (4):569. doi: 10.3390/ijms17040569.
   PubMed Web of Science ®Google Scholar
• Hua, S., Matos, M. B. C. De, Metselaar, J. M. Storm, G, and Hua, S. 2018. Current trends and challenges in the clinical translation of nanoparticulate nanomedicines: Pathways for translational development and commercialization Frontiers in Pharmacology 9 (July):1–14. doi: 10.3389/fphar.2018.00790.
   Google Scholar
• Huang, X., Y. Liu, Y. Zou, X. Liang, Y. Peng, D. J. McClements, and K. Hu. 2019. Encapsulation of resveratrol in zein/pectin core-shell nanoparticles: Stability, bioaccessibility, and antioxidant capacity after simulated gastrointestinal digestion. Food Hydrocolloids. 93 (February):261–9. doi: 10.1016/j.foodhyd.2019.02.039.
   Google Scholar
• Imran, A., M. U. Arshad, M. S. Arshad, M. Imran, F. Saeed, and M. Sohaib. 2018. Lipid peroxidation diminishing perspective of isolated theaflavins and thearubigins from black tea in arginine induced renal malfunctional rats. Lipids in Health and Disease 17:157. doi: 10.1186/s12944-018-0808-3
   Google Scholar
• Hu, B., Pan, C., Sun, Y., Hou, Z., Ye, H., Zeng, X. 2008. Optimization of fabrication parameters to produce chitosan - tripolyphosphate nanoparticles for delivery of tea catechins. Journal of Agricultural and Food Chemestry 56 (16):7451–8. doi: 10.1021/jf801111.
   Google Scholar
• Iskender, H., E. Dokumacioglu, T. M. Sen, I. Ince, Y. Kanbay, and S. Saral. 2017. The effect of hesperidin and quercetin on oxidative stress, NF- k B and SIRT1 levels in a STZ-induced experimental diabetes model. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 90:500–8. doi: 10.1016/j.biopha.2017.03.102.
   PubMed Web of Science ®Google Scholar
• Jafari, S. M., A. F. Esfanjani, and I. Katouzian. 2017. Safety of nanoencapsulated food ingredients. In Nanoencapsulation of food bioactive ingredients. Elsevier Inc., Amsterdam, Netherlands doi: 10.1016/B978-0-12-809740-3.00010-6.
   Google Scholar
• Jafari, S. M., and D. J. McClements. 2017. Nanotechnology approaches for increasing nutrient bioavailability. In Advances in food and nutrition research. 1st ed., vol. 81: 1–30. Elsevier Inc. doi: 10.1016/bs.afnr.2016.12.008.
   Google Scholar
• Jaime, L., and S. Santoyo. 2021. The health benefits of the bioactive compounds in foods. Foods 10 (2):3–6. doi: 10.3390/foods10020325.
   Web of Science ®Google Scholar
• Jakobek, L. 2015. Interactions of polyphenols with carbohydrates, lipids and proteins. Food Chemistry 175:556–67. doi: 10.1016/j.foodchem.2014.12.013.
   PubMed Web of Science ®Google Scholar
• Jamar, G., D. Estadella, and L. P. Pisani. 2017. Contribution of anthocyanin-rich foods in obesity control through gut microbiota interactions. BioFactors (Oxford, England) 43 (4):507–16. doi: 10.1002/biof.1365.
   PubMed Web of Science ®Google Scholar
• Jiang, J., I. Eliaz, and D. Sliva. 2013. Synergistic and additive effects of modified citrus pectin with two polybotanical compounds, in the suppression of invasive behavior of human breast and prostate cancer cells. Integrative Cancer Therapies 12 (2):145–52. doi: 10.1177/1534735412442369.
   PubMed Web of Science ®Google Scholar
• Jokioja, J., B. Yang, and K. M. Linderborg. 2021. Acylated anthocyanins: A review on their bioavailability and effects on postprandial carbohydrate metabolism and inflammation. Comprehensive Reviews in Food Science and Food Safety 20 (6):5570–615. doi: 10.1111/1541-4337.12836.
   PubMed Web of Science ®Google Scholar
• Kamel, S., N. Ali, K. Jahangir, S. M. Shah, and A. A. El-Gendy. 2008. Pharmaceutical significance of cellulose: A review. Express Polymer Letters 2 (11):758–78. doi: 10.3144/expresspolymlett.2008.90.
   Web of Science ®Google Scholar
• Kamiloglu, S., M. Tomas, T. Ozdal, and E. Capanoglu. 2021. Effect of food matrix on the content and bioavailability of flavonoids. Trends in Food Science & Technology 117 (April 2020):15–33. doi: 10.1016/j.tifs.2020.10.030.
   Google Scholar
• Kardum, N., and M. Glibetic. 2018. Polyphenols and their interactions with other dietary compounds: Implications for Human Health. In Advances in Food and Nutrition Research. 1st ed., vol. 84: 103–144. Academic Press. ISSN 1043-4526. doi: 10.1016/bs.afnr.2017.12.001.
   Google Scholar
• Karim, N., M. Rezaul, I. Shishir, Y. Li, O. Y. Zineb, J. Mo, J. Tangpong, and W. Chen. 2022. Pelargonidin- 3 - O -glucoside encapsulated pectin-chitosan-nanoliposomes recovers palmitic acid-induced hepatocytes injury. Antioxidants 11: 623. doi: 10.3390/antiox11040623
   Google Scholar
• Karimi, M., M. Eslami, P. Sahandi-Zangabad, F. Mirab, N. Farajisafiloo, Z. Shafaei, D. Ghosh, M. Bozorgomid, F. Dashkhaneh, and M. R. Hamblin. 2016. pH-Sensitive stimulus-responsive nanocarriers for targeted delivery of therapeutic agents. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology 8 (5):696–716. doi: 10.1002/wnan.1389.
   PubMed Web of Science ®Google Scholar
• Karimi, M., P. Sahandi Zangabad, S. Baghaee-Ravari, M. Ghazadeh, H. Mirshekari, and M. R. Hamblin. 2017. Smart nanostructures for cargo delivery: Uncaging and activating by light. Journal of the American Chemical Society 139 (13):4584–610. doi: 10.1021/jacs.6b08313.
   PubMed Web of Science ®Google Scholar
• Kasprzak-Drozd, K., T. Oniszczuk, M. Stasiak, and A. Oniszczuk. 2021. Beneficial effects of phenolic compounds on gut microbiota and metabolic syndrome. Internacional Journal Molecular Science 2;22(7):3715. doi: 10.3390/ijms22073715.
   Google Scholar
• Khalid, M., Bilal, M., D.-f, Huang, Saeed-ur-Rahman. (2019), Role of flavonoids in plant interactions with the environment and against human pathogens—A review. ScienceDirect Role of Flavonoids in Plant Interactions with the Environment and against Human Pathogens - A Review. 18(1), 211–230. doi: 10.1016/S2095-3119(19)62555-4.
   Google Scholar
• Khalil, I., W. A. Yehye, A. E. Etxeberria, A. A. Alhadi, S. M. Dezfooli, N. B. M. Julkapli, W. J. Basirun, and A. Seyfoddin. 2020. Nanoantioxidants: Recent trends in antioxidant delivery applications. Antioxidants 9 (1): 24 doi: 10.3390/antiox9010024.
   Web of Science ®Google Scholar
• Khotimchenko, M. 2020. Pectin polymers for colon-targeted antitumor drug delivery. International Journal of Biological Macromolecules 158:1110–24. doi: 10.1016/j.ijbiomac.2020.05.002.
   Web of Science ®Google Scholar
• Khvostov, M. V., S. A. Borisov, T. G. Tolstikova, A. V. Dushkin, B. D. Tsyrenova, Y. S. Chistyachenko, N. E. Polyakov, G. G. Dultseva, A. A. Onischuk, and S. V. An’kov. 2017. Supramolecular Complex of ibuprofen with larch polysaccharide arabinogalactan: Studies on bioavailability and pharmacokinetics. European Journal of Drug Metabolism and Pharmacokinetics 42 (3):431–40. doi: 10.1007/s13318-016-0357-y.
   PubMed Web of Science ®Google Scholar
• Kim, J., M.-B. Wie, M. Ahn, A. Tanaka, H. Matsuda, and T. Shin. 2019. Benefits of hesperidin in central nervous system disorders : A review. Anatomy Cell Biology 52(4):369–377. doi: 10.5115/acb.19.119
   Google Scholar
• Ko, A., J. S. Lee, H. Sop Nam, and H. Gyu Lee. 2017. Stabilization of black soybean anthocyanin by chitosan nanoencapsulation and copigmentation. Journal of Food Biochemistry 41 (2):e12316. doi: 10.1111/jfbc.12316.
   Web of Science ®Google Scholar
• Koch, W. 2019. Dietary polyphenols—important non-nutrients in the prevention of chronic noncommunicable. Nutrients 11(5):1039. doi: 10.3390/nu11051039
   Google Scholar
• Kong, R., X. Zhu, E. S. Meteleva, N. E. Polyakov, M. V. Khvostov, D. S. Baev, T. G. Tolstikova, A. V. Dushkin, and W. Su. 2018. Atorvastatin calcium inclusion complexation with polysaccharide arabinogalactan and saponin disodium glycyrrhizate for increasing of solubility and bioavailability. Drug Delivery and Translational Research 8 (5):1200–13. doi: 10.1007/s13346-018-0565-x.
   PubMed Web of Science ®Google Scholar
• Kou, L., Y. D. Bhutia, Q. Yao, Z. He, J. Sun, and V. Ganapathy. 2018. Transporter-guided delivery of nanoparticles to improve drug permeation across cellular barriers and drug exposure to selective cell types. Frontiers in Pharmacology 9 (January):27. doi: 10.3389/fphar.2018.00027.
   PubMedGoogle Scholar
• Kumar, M. N. V. R., R. A. A. Muzzarelli, C. Muzzarelli, H. Sashiwa, and A. J. Domb. 2004. Chitosan chemistry and pharmaceutical perspectives. Chemical Reviews 104 (12):6017–84. doi: 10.1021/cr030441b.
   PubMed Web of Science ®Google Scholar
• Kumar, S., and A. K. Pandey. 2013. Chemistry and biological activities of flavonoids: An overview. The Scientific World Journal 2013:1–16. doi: 10.1155/2013/162750.
   Web of Science ®Google Scholar
• Lara-Espinoza, C., E. Carvajal-Millán, R. Balandrán-Quintana, Y. López-Franco, and A. Rascón-Chu. 2018. Pectin and pectin-based composite materials: Beyond food texture. Molecules 23 (4):942 doi: 10.3390/molecules23040942.
   PubMed Web of Science ®Google Scholar
• Lee, H. C., A. M. Jenner, C. S. Low, and Y. K. Lee. 2006. Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota. Research in Microbiology 157 (9):876–84. doi: 10.1016/j.resmic.2006.07.004.
   PubMed Web of Science ®Google Scholar
• Leiva, A., S. Bonardd, M. Pino, C. Saldías, G. Kortaberria, and D. Radić. 2015. Improving the performance of chitosan in the synthesis and stabilization of gold nanoparticles. European Polymer Journal 68:419–31. doi: 10.1016/j.eurpolymj.2015.04.032.
   Web of Science ®Google Scholar
• Li, D., F. Xu, and J. Li. 2022. Chapter 4 - Pectin-based micro- and nanomaterials in drug delivery. In: Advances in Food and Nutrition Research. Academic Press 84:103–144. ISSN 1043-4526. doi: 10.1016/B978-0-323-90986-0.00015-7.
   Google Scholar
• Liang, J., L. Cao, L. Zhang, and X. Wan. 2014. Preparation, characterization, and in vitro antitumor activity of folate conjugated chitosan coated EGCG nanoparticles. Food Science and Biotechnology 23 (2):569–75. doi: 10.1007/s10068-014-0078-4.
   Web of Science ®Google Scholar
• Liang, S., X. Wu, X. Hu, T. Wang, and F. Jin. 2018. Recognizing depression from the microbiota – gut – brain axis. International Journal of Molecular Sciences 19 (6):1592. doi: 10.3390/ijms19061592.
   PubMed Web of Science ®Google Scholar
• Liang, J., H. Yan, H. J. Yang, H. W. Kim, X. Wan, J. Lee, and S. Ko. 2016. Synthesis and controlled-release properties of chitosan/β-Lactoglobulin nanoparticles as carriers for oral administration of epigallocatechin gallate. Food Science and Biotechnology 25 (6):1583–90. doi: 10.1007/s10068-016-0244-y.
   PubMed Web of Science ®Google Scholar
• Lila, M. A., B. Burton-Freeman, M. Grace, and W. Kalt. 2016. Unraveling anthocyanin bioavailability for human health. Annual Review of Food Science and Technology 7:375–93. doi: 10.1146/annurev-food-041715-033346.
   PubMed Web of Science ®Google Scholar
• Lin, K., Y. Li, E. D. Toit, L. Wendt, and J. Sun. 2021. Effects of polyphenol supplementations on improving depression, anxiety, and quality of life in patients with depression. Frontiers in Psychiatry 12 (November):1–13. doi: 10.3389/fpsyt.2021.765485.
   Google Scholar
• Lin, L., W. Xu, H. Liang, L. He, S. Liu, Y. Li, B. Li, and Y. Chen. 2015. Construction of pH-sensitive lysozyme/pectin nanogel for tumor methotrexate delivery. Colloids and Surfaces. B, Biointerfaces 126:459–66. doi: 10.1016/j.colsurfb.2014.12.051.
   PubMed Web of Science ®Google Scholar
• Lopez-Rubio, A., B. M. Flanagan, E. P. Gilbert, and M. J. Gidley. 2008. A novel approach for calculating starch crystallinity and its correlation with double helix content: A combined XRD and NMR study. Biopolymers 89 (9):761–8. doi: 10.1002/bip.21005.
   PubMed Web of Science ®Google Scholar
• Lu, X., J. Chen, Z. Guo, Y. Zheng, M. C. Rea, H. Su, X. Zheng, B. Zheng, and S. Miao. 2019. Using polysaccharides for the enhancement of functionality of foods: A review. Trends in Food Science & Technology 86 (October 2018):311–27. doi: 10.1016/j.tifs.2019.02.024.
   Google Scholar
• Luo, Y., and Q. Wang. 2014. Recent development of chitosan-based polyelectrolyte complexes with natural polysaccharides for drug delivery. International Journal of Biological Macromolecules 64:353–67. doi: 10.1016/j.ijbiomac.2013.12.017.
   PubMed Web of Science ®Google Scholar
• Maaliki, D., A. A. Shaito, G. Pintus, A. El-Yazbi, and A. H. Eid. 2019. Flavonoids in hypertension: A brief review of the underlying mechanisms. Current Opinion in Pharmacology 45 (May):57–65. doi: 10.1016/j.coph.2019.04.014.
   PubMedGoogle Scholar
• Magni, G., B. Riboldi, K. Petroni, and S. Ceruti. 2022. Flavonoids bridging the gut and the brain : Intestinal metabolic fate, and direct or indirect effects of natural supporters against neuroinflammation and neurodegeneration. Biochemical Pharmacology 205 (July):115257. doi: 10.1016/j.bcp.2022.115257.
   PubMedGoogle Scholar
• Manach, C., A. Scalbert, C. Morand, C. Rémésy, and L. Jiménez. 2004. Polyphenols: Food sources and bioavailability. The American Journal of Clinical Nutrition 79 (5):727–47. doi: 10.1093/ajcn/79.5.727.
   PubMed Web of Science ®Google Scholar
• Manzoor, M., J. Singh, J. D. Bandral, A. Gani, and R. Shams. 2020. Food hydrocolloids: Functional, nutraceutical and novel applications for delivery of bioactive compounds. International Journal of Biological Macromolecules 165 (Pt A):554–67. doi: 10.1016/j.ijbiomac.2020.09.182.
   PubMedGoogle Scholar
• Marín, L., E. M. Miguélez, C. J. Villar, and F. Lombó. 2015. Bioavailability of dietary polyphenols and gut microbiota metabolism : Antimicrobial properties. BioMed Research International 2015:1–18. doi: 10.1155/2015/905215.
   Web of Science ®Google Scholar
• Martínez Rivas, C. J., M. Tarhini, W. Badri, K. Miladi, H. Greige-Gerges, Q. A. Nazari, S. A. Galindo Rodríguez, R. Á. Román, H. Fessi, and A. Elaissari. 2017. Nanoprecipitation process: From encapsulation to drug delivery. International Journal of Pharmaceutics 532 (1):66–81. doi: 10.1016/j.ijpharm.2017.08.064.
   PubMed Web of Science ®Google Scholar
• Martínez-Ballesta, M., Á. Gil-Izquierdo, C. García-Viguera, and R. Domínguez-Perles. 2018. Nanoparticles and controlled delivery for bioactive compounds: Outlining challenges for new “smart-foods” for health. Foods 7 (5):1–29. doi: 10.3390/foods7050072.
   Web of Science ®Google Scholar
• Mas-Capdevila, J. Teichenne, C. Domenech-Coca, and A. Caimari. 2020. Ef ect of hesperidin on cardiovascular disease risk factors  : The Role of Intestinal Microbiota.
   Google Scholar
• Matalanis, A., O. G. Jones, and D. J. McClements. 2011. Structured biopolymer-based delivery systems for encapsulation, protection, and release of lipophilic compounds. Food Hydrocolloids. 25 (8):1865–80. doi: 10.1016/j.foodhyd.2011.04.014.
   Web of Science ®Google Scholar
• Mitchell, M. J., M. M. Billingsley, R. M. Haley, R. Langer, M. E. Wechsler, and N. A. Peppas. 2021. Engineering precision nanoparticles. Nature Reviews Drug Discovery 20: 101–124. doi: 10.1038/s41573-020-0090-8.
   Google Scholar
• Mohammadi, A., S. M. Jafari, E. Assadpour, and A. Faridi Esfanjani. 2016. Nano-encapsulation of olive leaf phenolic compounds through WPC-pectin complexes and evaluating their release rate. International Journal of Biological Macromolecules 82:816–22. doi: 10.1016/j.ijbiomac.2015.10.025.
   PubMed Web of Science ®Google Scholar
• Mohammed, H. A. 2022. Anthocyanins: Traditional uses, structural and functional variations, approaches to increase yields and products ‘ quality, hepatoprotection, liver longevity, and commercial products. International Journal Molecular Science 23(4):2149. doi: 10.3390/ijms23042149.
   Google Scholar
• Mohnen, D. 2008. Pectin structure and biosynthesis. Current Opinion in Plant Biology 11 (3):266–77. doi: 10.1016/j.pbi.2008.03.006.
   PubMed Web of Science ®Google Scholar
• Moreira, H. R., F. Munarin, R. Gentilini, L. Visai, P. L. Granja, M. C. Tanzi, and P. Petrini. 2014. Injectable pectin hydrogels produced by internal gelation: PH dependence of gelling and rheological properties. Carbohydrate Polymers 103 (1):339–47. doi: 10.1016/j.carbpol.2013.12.057.
   PubMedGoogle Scholar
• Morris, G. A., S. M. Kök, S. E. Harding, and G. G. Adams. 2010. Polysaccharide drug delivery systems based on pectin and chitosan. Biotechnology & Genetic Engineering Reviews 27 (1):257–84. doi: 10.1080/02648725.2010.10648153.
   PubMed Web of Science ®Google Scholar
• Mu, R., X. Hong, Y. Zheng, Y. Ni, Y. Li, J. Pang, Q. Wang, and J. Xiao. 2019. Recent trends and applications of cellulose nanocrystals in food industry. Trends in Food Science & Technology 93 (September):136–44. doi: 10.1016/j.tifs.2019.09.013.
   Google Scholar
• Mudgil, D., and S. Barak. 2013. Composition, properties and health benefits of indigestible carbohydrate polymers as dietary fiber: A review. International Journal of Biological Macromolecules 61:1–6. doi: 10.1016/j.ijbiomac.2013.06.044.
   PubMed Web of Science ®Google Scholar
• Munin, A., and F. Edwards-Lévy. 2011. Encapsulation of natural polyphenolic compounds; a review. In Pharmaceutics 3 (4):793–829. doi: 10.3390/pharmaceutics3040793.
   PubMedGoogle Scholar
• Muvva, A., I. A. Chacko, V. Ghate, and S. A. Lewis. 2020. Modified pectins for colon-specific drug delivery. Indian Journal of Pharmaceutical Education and Research 54 (2s):s12–s18. doi: 10.5530/ijper.54.2s.57.
   Google Scholar
• Nasrollahzadeh, M., M. Sajjadi, S. Iravani, and R. S. Varma. 2021. Starch, cellulose, pectin, gum, alginate, chitin and chitosan derived (nano)materials for sustainable water treatment: A review. Carbohydrate Polymers 251 (September 2020):116986. doi: 10.1016/j.carbpol.2020.116986.
   PubMedGoogle Scholar
• Needham, B. D., R. K. Daouk, and S. K. Mazmanian. 2020. Gut microbial molecules in behavioural and neurodegenerative conditions. Nature Reviews. Neuroscience 21 (12):717–31. doi: 10.1038/s41583-020-00381-0.
   PubMed Web of Science ®Google Scholar
• Neilson, A. P., K. M. Goodrich, and M. G. Ferruzzi. 2017. Bioavailability and metabolism of bioactive compounds from foods. In Nutrition in the prevention and treatment of disease. 4th ed.: 301-319 Elsevier Inc., Amsterdam, doi: 10.1016/B978-0-12-802928-2.00015-1.
   Google Scholar
• Nguyen, S., S. J. Alund, M. Hiorth, A. L. Kjøniksen, and G. Smistad. 2011. Studies on pectin coating of liposomes for drug delivery. Colloids and Surfaces. B, Biointerfaces 88 (2):664–73. doi: 10.1016/j.colsurfb.2011.07.058.
   PubMed Web of Science ®Google Scholar
• Ninan, N., M. Muthiah, I. K. Park, A. Elain, S. Thomas, and Y. Grohens. 2013. Pectin/carboxymethyl cellulose/microfibrillated cellulose composite scaffolds for tissue engineering. Carbohydrate Polymers 98 (1):877–85. doi: 10.1016/j.carbpol.2013.06.067.
   PubMed Web of Science ®Google Scholar
• Noore, S., N. K. Rastogi, C. O. Donnell, and B. Tiwari. 2021. Novel bioactive extraction and nano-encapsulation. Encyclopedia 1 (3):632–64. doi: 10.3390/encyclopedia1030052.
   Google Scholar
• Nurkeeva, Z. S., G. A. Mun, and V. V. Khutoryanskiy. 2003. Interpolymer complexes of water-soluble nonionic polysaccharides with polycarboxylic acids and their applications. Macromolecular Bioscience 3 (6):283–95. doi: 10.1002/mabi.200390037.
   Web of Science ®Google Scholar
• Obayashi, S. K., M. S. Hinohara, T. N. Agai, and Y. K. Onishi. 2013. Transport mechanisms for soy isoflavones and microbial metabolites dihydrogenistein and dihydrodaidzein across monolayers and membranes. Bioscience, Biotechnology and Biochemistry 77 (11):2210–7. doi: 10.1271/bbb.130404.
   Google Scholar
• Osadchiy, V., C. R. Martin, and E. A. Mayer. 2020. Gut microbiome and modulation of CNS function. Comprehensive Physiology 10:57–72. doi: 10.1002/cphy.c180031.
   Web of Science ®Google Scholar
• Osvaldt Rosales, T. K., M. Pessoa da Silva, F. R. Lourenço, N. M. Aymoto Hassimotto, and J. P. Fabi. 2021. Nanoencapsulation of anthocyanins from blackberry (Rubus spp.) through pectin and lysozyme self-assembling. Food Hydrocolloids. 114 (December 2020):106563. doi: 10.1016/j.foodhyd.2020.106563.
   Google Scholar
• Ozdal, T., D. A. Sela, J. Xiao, D. Boyacioglu, F. Chen, and E. Capanoglu. 2016. The reciprocal interactions between polyphenols and gut microbiota and effects on bioaccessibility. Nutrients 8 (2):78. doi: 10.3390/nu8020078.
   PubMed Web of Science ®Google Scholar
• Pacheco-Ordaz, R., M. Antunes-Ricardo, J. A. Gutiérrez-Uribe, and G. A. González-Aguilar. 2018. Intestinal permeability and cellular antioxidant activity of phenolic compounds from mango (Mangifera indica cv. ataulfo) peels. International Journal of Molecular Sciences 19 (2):514 doi: 10.3390/ijms19020514.
   PubMed Web of Science ®Google Scholar
• Panchal, S. K., O. D. John, M. L. Mathai, and L. Brown. 2022. Anthocyanins in chronic diseases : The power of purple. Nutrients 14(10):2161. doi: 10.3390/nu14102161.
   Google Scholar
• Panche, A. N., A. D. Diwan, and S. R. Chandra. 2016. Flavonoids: An overview. Journal of Nutritional Science 5:e47. doi: 10.1017/jns.2016.41.
   PubMed Web of Science ®Google Scholar
• Pandey, M., N. Mohamad, and M. C. I. M. Amin. 2014. Bacterial cellulose/acrylamide pH-sensitive smart hydrogel: Development, characterization, and toxicity studies in ICR mice model. Molecular Pharmaceutics 11 (10):3596–608. doi: 10.1021/mp500337r.
   PubMed Web of Science ®Google Scholar
• Pandima, K., D. Sheeja, S. Fazel, A. Sureda, J. Xiao, S. Mohammad, and M. Daglia. 2015. Kaempferol and inflammation: From chemistry to medicine. Pharmacological Research 99:1–10. doi: 10.1016/j.phrs.2015.05.002.
   PubMed Web of Science ®Google Scholar
• Paredes, A. J., C. M. Asencio, L. J. Manuel, and D. A. Allemandi. 2016. Nano encapsulation in the food industry : Manufacture, application sand characterization. Journal of Bioengenireering and Nanoprocessing 1 (1):56–79.
   Google Scholar
• Park, J. H., G. Saravanakumar, K. Kim, and I. C. Kwon. 2010. Targeted delivery of low molecular drugs using chitosan and its derivatives. Advanced Drug Delivery Reviews 62 (1):28–41. doi: 10.1016/j.addr.2009.10.003.
   PubMed Web of Science ®Google Scholar
• Pateiro, M., B. Gómez, P. E. S. Munekata, F. J. Barba, P. Putnik, D. B. Kovačević, and J. M. Lorenzo. 2021. Nanoencapsulation of promising bioactive compounds to improve their absorption, stability, functionality and the appearance of the final food products. Molecules 26 (6):1547. doi: 10.3390/molecules26061547.
   PubMed Web of Science ®Google Scholar
• Peng, H., S. Chen, M. Luo, F. Ning, X. Zhu, and H. Xiong. 2016. Preparation and self-assembly mechanism of bovine serum albumin-citrus peel pectin conjugated hydrogel: A potential delivery system for Vitamin C. Journal of Agricultural and Food Chemistry 64 (39):7377–84. doi: 10.1021/acs.jafc.6b02966.
   PubMed Web of Science ®Google Scholar
• Pérez, S., and D. Samain. 2010. Structure and engineering of celluloses. Advances in Carbohydrate Chemistry and Biochemistry 64 (C):25–116. doi: 10.1016/S0065-2318(10)64003-6.
   PubMedGoogle Scholar
• Polia, F., M. Pastor-Belda, A. Martínez-Blázquez, M. N. Horcajada, F. A. Tomás-Barberán, and R. García-Villalba. 2022. Technological and biotechnological processes to enhance the bioavailability of dietary (poly)phenols in humans. Journal of Agricultural and Food Chemistry 70 (7):2092–107. doi: 10.1021/acs.jafc.1c07198.
   PubMed Web of Science ®Google Scholar
• Posocco, B., E. Dreussi, J. De Santa, G. Toffoli, M. Abrami, F. Musiani, M. Grassi, R. Farra, F. Tonon, G. Grassi, et al. 2015. Polysaccharides for the delivery of antitumor drugs. Materials 8 (5):2569–615. doi: 10.3390/ma8052569.
   Web of Science ®Google Scholar
• Prabaharan, M., and J. F. Mano. 2005. Chitosan-based particles as controlled drug delivery systems. Drug Delivery 12 (1):41–57. doi: 10.1080/10717540590889781.
   PubMed Web of Science ®Google Scholar
• Prado, S. B. R., do, Castro-Alves, V. C. Ferreira, G. F, and Fabi, J. P. 2019. Ingestion of non-digestible carbohydrates from plant-source foods and decreased risk of colorectal cancer: A review on the biological effects and the mechanisms of action. Frontiers in Nutrition 6 (May):72. doi: 10.3389/fnut.2019.00072.
   PubMedGoogle Scholar
• Quadrado, R. F. N., and A. R. Fajardo. 2020. Microparticles based on carboxymethyl starch/chitosan polyelectrolyte complex as vehicles for drug delivery systems. Arabian Journal of Chemistry 13 (1):2183–94. doi: 10.1016/j.arabjc.2018.04.004.
   Web of Science ®Google Scholar
• Rashidinejad, A., S. Boostani, A. Babazadeh, A. Rehman, A. Rezaei, S. Akbari-Alavijeh, R. Shaddel, and S. M. Jafari. 2021. Opportunities and challenges for the nanodelivery of green tea catechins in functional foods. Food Research International (Ottawa, Ont.) 142 (February):110186. doi: 10.1016/j.foodres.2021.110186.
   PubMedGoogle Scholar
• Rastogi, H., and S. Jana. 2016. Evaluation of physicochemical properties and intestinal permeability of six dietary polyphenols in human intestinal colon adenocarcinoma Caco-2 cells. European Journal of Drug Metabolism and Pharmacokinetics 41 (1):33–43. doi: 10.1007/s13318-014-0234-5.
   PubMed Web of Science ®Google Scholar
• Rehman, A., S. Mahdi, Q. Tong, T. Riaz, E. Assadpour, R. Muhammad, S. Niazi, I. Mahmood, Q. Shehzad, A. Ali, et al. 2020. Drug nanodelivery systems based on natural polysaccharides against different diseases. Advances in Colloid and Interface Science 284:102251. doi: 10.1016/j.cis.2020.102251.
   PubMed Web of Science ®Google Scholar
• Reichembach, L. H., C. Lúcia, and D. O. Petkowicz. 2021. Food hydrocolloids pectins from alternative sources and uses beyond sweets and jellies : An overview. Food Hydrocolloids. 118 (December 2020):106824. doi: 10.1016/j.foodhyd.2021.106824.
   Google Scholar
• Rein, M. J., M. Renouf, C. Cruz-Hernandez, L. Actis-Goretta, S. K. Thakkar, and M. da Silva Pinto. 2013. Bioavailability of bioactive food compounds: A challenging journey to bioefficacy. British Journal of Clinical Pharmacology 75 (3):588–602. doi: 10.1111/j.1365-2125.2012.04425.x.
   PubMed Web of Science ®Google Scholar
• Rinaudo, M. 2006. Chitin and chitosan: properties and applications. Progress in Polymer Science (Oxford) 31 (7):603–32. doi: 10.1016/j.progpolymsci.2006.06.001.
   Web of Science ®Google Scholar
• Rodríguez-Daza, M. C., L. Daoust, L. Boutkrabt, G. Pilon, T. Varin, S. Dudonné, É. Levy, A. Marette, D. Roy, and Y. Desjardins. 2020. Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice. Scientific Reports 10 (1):2217. doi: 10.1038/s41598-020-58863-1.
   PubMed Web of Science ®Google Scholar
• Rosales, T. K. O., and J. P. Fabi. 2023a. Pectin-based nanoencapsulation strategy to improve the bioavailability of bioactive compounds. International Journal of Biological Macromolecules 229 (December 2022):11–21. doi: 10.1016/j.ijbiomac.2022.12.292.
   PubMedGoogle Scholar
• Rosales, T. K. O., and J. P. Fabi. 2023b. Polysaccharides as natural nanoencapsulants for controlled. In: Smart nanomaterials for bioencapsulation. Elsevier, Amsterdam 1:23–38. ISBN:9780323912297
   Google Scholar
• Rosales, T. K. O., and J. P. Fabi. 2023b. Valorization of polyphenolic compounds from food industry by-products for application in polysaccharide-based nanoparticles. Frontiers in Nutrition 10:1144677. doi: 10.3389/fnut.2023.1144677.
   PubMed Web of Science ®Google Scholar
• Rosales, O., Freitas, L. D. Rebouças, K. Minami, A. Toniazzo, T., and C. C. 2023. Food hydrocolloids nanoencapsulated anthocyanins : A new technological approach to increase physical-chemical stability and bioaccessibility 139: 108516 (September 2022) doi: 10.1016/j.foodhyd.2023.108516.
   Google Scholar
• Rosales, T. K. O., Hassimotto, N. M. A., Lajolo, F. M., Fabi, J. P. 2022. Nanotechnology as a tool to mitigate the effects of intestinal microbiota on metabolization of anthocyanins. Antioxidants11(3):506. doi: 10.3390/antiox11030506.
   Google Scholar
• Rostamabadi, H., S. R. Falsafi, and S. M. Jafari. 2019. Starch-based nanocarriers as cutting-edge natural cargos for nutraceutical delivery. Trends in Food Science & Technology Starch-Based Nanocarriers as Cutting-Edge Natural Cargos for Nutraceutical Delivery 88 (March):397–415. doi: 10.1016/j.tifs.2019.04.004.
   Google Scholar
• Sadeghi, R., L. Mehryar, M. Karimi, and J. Kokini. 2017. Nanocapsule formation by individual biopolymer nanoparticles. In Nanoencapsulation technologies for the food and nutraceutical industries 1. Elsevier Inc., Amsterdam. doi: 10.1016/B978-0-12-809436-5.00011-2.
   Google Scholar
• Sadeghi, M. and G. Rezanejade Bardajee. 2018. Dye removal from aqueous solutions using novel nanocomposite hydrogel derived from sodium montmorillonite nanoclay and modified starch. International Journal of Environmental Science and Technology 15 (11):2303–16. doi: 10.1007/s13762-017-1531-8.
   Web of Science ®Google Scholar
• Salarbashi, D., J. Bazeli, and E. F. Rad. 2020. An update on the new achievements in the nanocapsulation of anthocyanins. Nanomedicine Journal 0 (2):87–97. doi: 10.22038/nmj.2020.14628.
   Google Scholar
• Salehi, B., J. Sharifi-Rad, F. Cappellini, Z. Reiner, D. Zorzan, M. Imran, B. Sener, M. Kilic, M. El-Shazly, N. M. Fahmy, et al. 2020. The therapeutic potential of anthocyanins: Current approaches based on their molecular mechanism of action. Frontiers in Pharmacology 11 (August):1300. doi: 10.3389/fphar.2020.01300.
   PubMedGoogle Scholar
• Santos, H. A., and I. N. Savina. 2023. Introduction to the RSC advances themed collection on nanomaterials in drug delivery. RSC Advances 13 (3):1933–4. doi: 10.1039/d2ra90132c.
   PubMed Web of Science ®Google Scholar
• Sarkar, A., S. Zhang, B. Murray, J. A. Russell, and S. Boxal. 2017a. Modulating in vitro gastric digestion of emulsions using composite whey protein-cellulose nanocrystal interfaces. Colloids and Surfaces. B, Biointerfaces 158:137–46. doi: 10.1016/j.colsurfb.2017.06.037.
   PubMed Web of Science ®Google Scholar
• Sato, M., A. Okuno, K. Suzuki, N. Ohsawa, E. Inoue, Y. Miyaguchi, and A. Toyoda. 2019. Dietary intake of the citrus flavonoid hesperidin affects stress-resilience and brain kynurenine levels in a subchronic and mild social defeat stress model in mice. Bioscience, Biotechnology, and Biochemistry 83 (9):1756–65. doi: 10.1080/09168451.2019.1621152.
   PubMed Web of Science ®Google Scholar
• Selyutina, O., I. Apanasenko, A. Shilov, S. Khalikov, and N. Polyakov. 2017. Effect of natural polysaccharides and oligosaccharides on the permeability of cell membranes. Russian Chemical Bulletin 66 (1):129–35. doi: 10.1007/s11172-017-1710-2.
   Web of Science ®Google Scholar
• Semwal, D. K., R. B. Semwal, S. Combrinck, and A. Viljoen. 2016. Myricetin : A dietary molecule with diverse. Nutrients 8 (2):90. doi: 10.3390/nu8020090.
   PubMed Web of Science ®Google Scholar
• Shen, Y., N. Zhang, J. Tian, G. Xin, L. Liu, X. Sun, and B. Li. 2022. Advanced approaches for improving bioavailability and controlled release of anthocyanins. Journal of Controlled Release : official Journal of the Controlled Release Society 341 (June 2021):285–99. doi: 10.1016/j.jconrel.2021.11.031.
   PubMedGoogle Scholar
• Shishir, M. R. I., N. Karim, V. Gowd, J. Xie, X. Zheng, and W. Chen. 2019. Pectin-chitosan conjugated nanoliposome as a promising delivery system for neohesperidin: Characterization, release behavior, cellular uptake, and antioxidant property. Food Hydrocolloids. 95 (December 2018):432–44. doi: 10.1016/j.foodhyd.2019.04.059.
   Google Scholar
• Shivashankara, K. S., and S. N. Acharya. 2010. Bioavailability of dietary polyphenols and the cardiovascular diseases. The Open Nutraceuticals Journal 3 (1):227–41. doi: 10.2174/1876396001003010227.
   Google Scholar
• Siddiqui, S., N. Bahmid, A. Taha, I. Khalifa, S. Khan, H. Rostamabadi, and S. Jafari. 2022. Recent advances in food applications of phenolic-loaded micro/nanodelivery systems. Critical Reviews in Food Science and Nutrition :1–21. doi: 10.1080/10408398.2022.2056870.
   Web of Science ®Google Scholar
• Siddiqui, I. A., D. J. Bharali, M. Nihal, V. M. Adhami, N. Khan, J. C. Chamcheu, M. I. Khan, S. Shabana, S. A. Mousa, and H. Mukhtar. 2014. Excellent anti-proliferative and pro-apoptotic effects of (-)-epigallocatechin-3-gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivo. Nanomedicine : nanotechnology, Biology, and Medicine 10 (8):1619–26. doi: 10.1016/j.nano.2014.05.007.
   PubMed Web of Science ®Google Scholar
• Singh, A. K. Cabral, C. Kumar, R. Ganguly, R, and Pandey, A. K. 2019. Beneficial ef ects of dietary polyphenols on gut microbiota and strategies to improve Delivery Efficiency. Nutrients. Sep 13;11(9):2216. doi: 10.3390/nu11092216.
   Google Scholar
• Singh, A. N., and A. Yethiraj. 2020. Driving force for the complexation of charged polypeptides. The Journal of Physical Chemistry. B 124 (7):1285–92. doi: 10.1021/acs.jpcb.9b09553.
   PubMed Web of Science ®Google Scholar
• Sogias, I. A., A. C. Williams, and V. V. Khutoryanskiy. 2008. Why is chitosan mucoadhesive? Biomacromolecules 9 (7):1837–42. doi: 10.1021/bm800276d.
   PubMed Web of Science ®Google Scholar
• Song, J., Y. Yu, M. Chen, Z. Ren, L. Chen, C. Fu, Z. f Ma, and Z. Li. 2022. Advancement of protein- and polysaccharide-based biopolymers for anthocyanin encapsulation. Frontiers in Nutrition 9 (June):938829. doi: 10.3389/fnut.2022.938829.
   PubMedGoogle Scholar
• Sriamornsak, P. 2011. Application of pectin in oral drug delivery. Expert Opinion on Drug Delivery 8 (8):1009–23. doi: 10.1517/17425247.2011.584867.
   PubMed Web of Science ®Google Scholar
• Stenger, C., B. Zeeb, J. Hinrichs, and J. Weiss. 2017. Formation of concentrated biopolymer particles composed of oppositely charged WPI and pectin for food applications. Journal of Dispersion Science and Technology 38 (9):1258–65. doi: 10.1080/01932691.2016.1234381.
   Web of Science ®Google Scholar
• Suhag, R., R. Kumar, A. Dhiman, A. Sharma, P. Prabhakar, K. Gopalakrishnan, R. Kumar, and A. Singh. 2022. Fruit peel bioactives, valorisation into nanoparticles and potential applications: A review. Critical Reviews in Food Science and Nutrition 24:1–20. doi: 10.1080/10408398.2022.2043237.
   Web of Science ®Google Scholar
• Suleria, H. A. R., C. J. Barrow, and F. R. Dunshea. 2020. Screening and characterization of phenolic compounds and their antioxidant capacity in different fruit peels. Foods 9(9):1206. doi: 10.3390/foods9091206.
   Google Scholar
• Sun, J., J. Chen, Z. Mei, Z. Luo, L. Ding, X. Jiang, and W. Bai. 2020. Synthesis, structural characterization, and evaluation of cyanidin-3-O-glucoside-loaded chitosan nanoparticles. Food Chemistry 330 (April):127239. doi: 10.1016/j.foodchem.2020.127239.
   PubMedGoogle Scholar
• Tahir, A., R. Shabir Ahmad, M. Imran, M. H. Ahmad, M. Kamran Khan, N. Muhammad, M. U. Nisa, M. Tahir Nadeem, A. Yasmin, H. S. Tahir, et al. 2021. Recent approaches for utilization of food components as nano-encapsulation: a review. International Journal of Food Properties 24 (1):1074–96. doi: 10.1080/10942912.2021.1953067.
   Web of Science ®Google Scholar
• Takeuchi, H., J. Thongborisute, Y. Matsui, H. Sugihara, H. Yamamoto, and Y. Kawashima. 2005. Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems. Advanced Drug Delivery Reviews 57 (11):1583–94. doi: 10.1016/j.addr.2005.07.008.
   PubMed Web of Science ®Google Scholar
• Tanaka, K. T. Tanaka, H. Yamamura, and T. Matsui. 2019. Absorption and metabolic behavior of hesperidin (Rutinosylated hesperetin) after single oral administration to sprague-dawley rats. Journal of Agricultural and Food Chemistry 67 (35):9812–9. doi: 10.1021/acs.jafc.9b03594.
   PubMed Web of Science ®Google Scholar
• Talavéra, S., C. Felgines, O. Texier, C. Besson, C. Manach, J. L. Lamaison, and C. Rémésy. 2004. Anthocyanins are efficiently absorbed from the small intestine in rats. The Journal of Nutrition 134 (9):2275–9. doi: 10.1093/jn/134.9.2275.
   PubMed Web of Science ®Google Scholar
• Tian, L., Y. Tan, G. Chen, G. Wang, J. Sun, S. Ou, W. Chen, and W. Bai. 2019. Metabolism of anthocyanins and consequent effects on the gut microbiota. Critical Reviews in Food Science and Nutrition 59 (6):982–91. doi: 10.1080/10408398.2018.1533517.
   PubMed Web of Science ®Google Scholar
• Tie, S., and M. Tan. 2022. Current advances in multifunctional nanocarriers based on marine polysaccharides for colon delivery of food polyphenols. Journal of Agricultural and Food Chemistry 70 (4):903–15. doi: 10.1021/acs.jafc.1c05012.
   PubMed Web of Science ®Google Scholar
• Tomas, M. 2022. Effect of dietary fiber addition on the content and in vitro bioaccessibility of antioxidants in red raspberry puree. Food Chemistry 375 (June 2021):131897. doi: 10.1016/j.foodchem.2021.131897.
   PubMedGoogle Scholar
• Tomas-Barberan, F. A., M. V. Selma, and J. C. Esp. 2018. B ©. Journal of Agricultural and Food Chemistry 66 (14):3593–4. doi: 10.1021/acs.jafc.8b00827.
   PubMed Web of Science ®Google Scholar
• Toydemir, G., D. Boyacioglu, E. Capanoglu, I. M. Van Der Meer, M. M. M. Tomassen, R. D. Hall, J. J. Mes, and J. Beekwilder. 2013. Investigating the transport dynamics of anthocyanins from unprocessed fruit and processed fruit juice from sour cherry (Prunus cerasus L.) across intestinal epithelial cells. Journal of Agricultural and Food Chemistry 61 (47):11434–41. doi: 10.1021/jf4032519.
   PubMed Web of Science ®Google Scholar
• Tsirigotis-Maniecka, M., Ł. Lamch, I. Chojnacka, R. Gancarz, and K. A. Wilk. 2017. Microencapsulation of hesperidin in polyelectrolyte complex microbeads : Physico-chemical evaluation and release behavior. Journal of Food Engineering 214:104–16. doi: 10.1016/j.jfoodeng.2017.06.015.
   Web of Science ®Google Scholar
• Van de Velde, F., M. E. Pirovani, and S. R. Drago. 2018. Bioaccessibility analysis of anthocyanins and ellagitannins from blackberry at simulated gastrointestinal and colonic levels. Journal of Food Composition and Analysis 72 (March):22–31. doi: 10.1016/j.jfca.2018.05.007.
   Google Scholar
• Van de Velde, F., C. Vignatti, M. Paula Méndez-Galarraga, M. Gomila, C. Fenoglio, M. Donda Zbinden, and M. Élida Pirovani. 2022. Intestinal and colonic bioaccessibility of phenolic compounds from fruit smoothies as affected by the thermal processing and the storage conditions. Food Research International (Ottawa, Ont.) 155 (February):111086. doi: 10.1016/j.foodres.2022.111086.
   PubMedGoogle Scholar
• van Dorsten, F. A., C. H. Grün, E. J. J. van Velzen, D. M. Jacobs, R. Draijer, and J. P. M. van Duynhoven. 2010. The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics. Molecular Nutrition & Food Research 54 (7):897–908. doi: 10.1002/mnfr.200900212.
   PubMed Web of Science ®Google Scholar
• Verediano, T. A., H. Stampini Duarte Martino, M. C. Dias Paes, and E. Tako. 2021. Effects of anthocyanin on intestinal health: A systematic review. Nutrients 13 (4): 1331. doi: 10.3390/nu13041331.
   PubMed Web of Science ®Google Scholar
• Victoria-Campos, C. I., J. d J. Ornelas-Paz, N. E. Rocha-Guzmán, J. A. Gallegos-Infante, M. L. Failla, J. D. Pérez-Martínez, C. Rios-Velasco, and V. Ibarra-Junquera. 2022. Gastrointestinal metabolism and bioaccessibility of selected anthocyanins isolated from commonly consumed fruits. Food Chemistry 383 (July 2021):132451. doi: 10.1016/j.foodchem.2022.132451.
   PubMedGoogle Scholar
• Viebke, C., S. Al-Assaf, and G. O. Phillips. 2014. Food hydrocolloids and health claims. Bioactive Carbohydrates and Dietary Fibre 4 (2):101–14. doi: 10.1016/j.bcdf.2014.06.006.
   Google Scholar
• Walia, N., N. Dasgupta, S. Ranjan, C. Ramalingam, and M. Gandhi. 2019. Methods for nanoemulsion and nanoencapsulation of food bioactives. Environmental Chemistry Letters 17 (4):1471–83. doi: 10.1007/s10311-019-00886-w.
   Web of Science ®Google Scholar
• Wang, Z., C. J. Barrow, and F. R. Dunshea. 2021. A comparative investigation on phenolic composition, characterization and antioxidant potentials of five different australian grown pear varieties. Antioxidants 10(2):151. doi: 10.3390/antiox10020151.
   Google Scholar
• Wang, D., J. Tan, H. Kang, L. Ma, X. Jin, R. Liu, and Y. Huang. 2011. Synthesis, self-assembly and drug release behaviors of pH-responsive copolymers ethyl cellulose-graft-PDEAEMA through ATRP. Synthesis, Self-Assembly and Drug Release Behaviors of pH-Responsive Copolymers Ethyl Cellulose- graft -PDEAEMA through ATRP 84 (1):195–202. doi: 10.1016/j.carbpol.2010.11.023.
   Google Scholar
• Westfall, S., and G. M. Pasinetti. 2019. The gut microbiota links dietary polyphenols with management of psychiatric mood disorders. Frontiers in Neuroscience 13 (November):1–24. doi: 10.3389/fnins.2019.01196.
   Google Scholar
• Wijaya, C. J.,S. Ismadji, andS. Gunawan. 2021. A Review of Lignocellulosic-Derived Nanoparticles for Drug Delivery Applications: Lignin Nanoparticles, Xylan Nanoparticles, and Cellulose Nanocrystals. Molecules 26 (3):676 10.3390/molecules26030676.
   PubMed Web of Science ®Google Scholar
• Williamson, R. E., J. E. Burn, and C. H. Hocart. 2002. Towards the mechanism of cellulose synthesis. Trends in Plant Science 7 (10):461–7. doi: 10.1016/S1360-1385(02)02335-X.
   PubMed Web of Science ®Google Scholar
• Wu, C. L., Chen, Q. H. Li, X. Y. Su, J. Hui, He, S. Liu, J, and Yuan, Y. 2020. Formation and characterisation of food protein–polysaccharide thermal complex particles: Effects of pH, temperature and polysaccharide type. International Journal of Food Science & Technology 55 (3):1368–74. doi: 10.1111/ijfs.14416.
   Web of Science ®Google Scholar
• Wu, T., C. Wu, S. Fu, L. Wang, C. Yuan, S. Chen, and Y. Hu. 2017. Integration of lysozyme into chitosan nanoparticles for improving antibacterial activity. Carbohydrate Polymers 155:192–200. doi: 10.1016/j.carbpol.2016.08.076.
   PubMed Web of Science ®Google Scholar
• Wusigale, Liang, L., Yangchao, Luo. (2020). Casein and pectin: Structures, interactions, and applications. Trends in Food Science and Technology, 97(September 2019), 391–403. doi: 10.1016/j.tifs.2020.01.027.
   Google Scholar
• Yahfoufi, N., N. Alsadi, M. Jambi, and C. Matar. 2018. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients 10 (11):1–23. doi: 10.3390/nu10111618.
   Web of Science ®Google Scholar
• Yang, Z., D. Julian, X. Peng, Z. Xu, M. Meng, L. Chen, and Z. Jin. 2023. Fabrication of Zein – carboxymethyl cellulose nanoparticles for co-delivery of quercetin and resveratrol. Journal of Food Engineering 341 (October 2022) doi: 10.1016/j.jfoodeng.2022.111322
   Google Scholar
• Yu, H., and Q. Huang. 2010. Enhanced in vitro anti-cancer activity of curcumin encapsulated in hydrophobically modified starch. Food Chemistry 119 (2):669–74. doi: 10.1016/j.foodchem.2009.07.018.
   Web of Science ®Google Scholar
• Zamora-Ros, R., C. Biessy, J. A. Rothwell, A. Monge, M. Lajous, A. Scalbert, R. López-Ridaura, and I. Romieu. 2018. Dietary polyphenol intake and their major food sources in the Mexican Teachers’ Cohort. The British Journal of Nutrition 120 (3):353–60. doi: 10.1017/S0007114518001381.
   PubMed Web of Science ®Google Scholar
• Zhai, X., D. Lin, D. Liu, and X. Yang. 2018. Emulsions stabilized by nanofibers from bacterial cellulose: New potential food-grade Pickering emulsions. Food Research International (Ottawa, Ont.) 103 (October 2017):12–20. doi: 10.1016/j.foodres.2017.10.030.
   PubMedGoogle Scholar
• Zhang, L., A. Beatty, L. Lu, A. Abdalrahman, T. M. Makris, G. Wang, and Q. Wang. 2020. Materials science & engineering c microfluidic-assisted polymer-protein assembly to fabricate homogeneous functionalnanoparticles. Materials Science & Engineering. C, Materials for Biological Applications 111 (January):110768. doi: 10.1016/j.msec.2020.110768.
   PubMedGoogle Scholar
• Zhang, J., G. Jia, Z. Wanbin, J. Minghao, Y. Wei, J. Hao, X. Liu, Z. Gan, and A. Sun. 2021. Nanoencapsulation of zeaxanthin extracted from Lycium barbarum L. by complex coacervation with gelatin and CMC. Food Hydrocolloids. 112 (December 2019):106280. doi: 10.1016/j.foodhyd.2020.106280.
   Google Scholar
• Zhang Z, Li X, Sang S, McClements DJ, Chen L, Long J, Jiao A, Jin Z, Qiu C. 2022. Polyphenols as plant-based nutraceuticals: Health effects, encapsulation, nano-delivery, and application. Foods 23;11(15):2189. doi: 10.3390/foods11152189.
   Google Scholar
• Zhang, H., and R. Tsao. 2016. Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Current Opinion in Food Science 8:33–42. doi: 10.1016/j.cofs.2016.02.002.
   Web of Science ®Google Scholar
• Zhang, Q., Y. Zhou, W. Yue, W. Qin, H. Dong, and T. Vasanthan. 2021. Nanostructures of protein-polysaccharide complexes or conjugates for encapsulation of bioactive compounds. Trends in Food Science & Technology 109 (January):169–96. doi: 10.1016/j.tifs.2021.01.026.
   Google Scholar
• Zhao, X., X. Zhang, S. Tie, S. Hou, H. Wang, Y. Song, R. Rai, and M. Tan. 2020a. Facile synthesis of nano-nanocarriers from chitosan and pectin with improved stability and biocompatibility for anthocyanins delivery: An in vitro and in vivo study. Food Hydrocolloids. 109 (February):106114. doi: 10.1016/j.foodhyd.2020.106114.
   Google Scholar
• Zhao, X., X. Zhang, S. Tie, S. Hou, H. Wang, Y. Song, R. Rai, and M. Tan. 2020b. Food HYDROCOLLOIDS FACILe synthesis of nano-nanocarriers from chitosan and pectin with improved stability and biocompatibility for anthocyanins delivery: An in vitro and in vivo study. Food Hydrocolloids. 109 (June):106114. doi: 10.1016/j.foodhyd.2020.106114.
   Google Scholar
• Zhou, N., X. Gu, T. Zhuang, Y. Xu, L. Yang, and M. Zhou. 2020. Gut microbiota: A pivotal hub for polyphenols as antidepressants. Journal of Agricultural and Food Chemistry 68 (22):6007–20. doi: 10.1021/acs.jafc.0c01461.
   PubMed Web of Science ®Google Scholar
• Zhu, F. 2017. Encapsulation and delivery of food ingredients using starch based systems. Food Chemistry 229:542–52. doi: 10.1016/j.foodchem.2017.02.101.
   PubMed Web of Science ®Google Scholar