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Review Article

Improving potential strategies for biological activities of phlorotannins derived from seaweeds

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References

  • Ahn, G., Y. Amagai, A. Matsuda, S.-M. Kang, W. Lee, K. Jung, K. Oida, H. Jang, S. Ishizaka, K. Matsuda, et al. 2015. Dieckol, a phlorotannin of Ecklonia cava, suppresses IgE-mediated mast cell activation and passive cutaneous anaphylactic reaction. Experimental Dermatology 24 (12):968–70. doi:10.1111/exd.12814.
  • Ahn, M.-J., K.-D. Yoon, S.-Y. Min, J. S. Lee, J. H. Kim, T. G. Kim, S. H. Kim, N.-G. Kim, H. Huh, and J. Kim. 2004. Inhibition of HIV-1 reverse transcriptase and protease by phlorotannins from the brown alga Ecklonia cava. Biological & Pharmaceutical Bulletin 27 (4):544–7. doi:10.1248/bpb.27.544.
  • Amanzadeh, E., A. Esmaeili, R. E. N. Abadi, N. Kazemipour, Z. Pahlevanneshan, and S. Beheshti. 2019. Quercetin conjugated with superparamagnetic iron oxide nanoparticles improves learning and memory better than free quercetin via interacting with proteins involved in LTP. Scientific Reports 9 (1):6876. doi:10.1038/s41598-019-43345-w.
  • Amjadi, S., S. Gholizadeh, A. Ebrahimi, H. Almasi, H. Hamishehkar, and R. A. Taheri. 2022. Development and characterization of the carvone-loaded zein/pullulan hybrid electrospun nanofibers for food and medical applications. Industrial Crops and Products 183:114964. doi:10.1016/j.indcrop.2022.114964.
  • Ank, G., B. A. P. da Gama, and R. C. Pereira. 2019. Latitudinal variation in phlorotannin contents from Southwestern Atlantic brown seaweeds. PeerJ. 7: E 7379. doi:10.7717/peerj.7379.
  • Arnold, T., and N. Targett. 2003. To grow and defend: Lack of tradeoffs for brown algal phlorotannins. Oikos 100 (2):406–8. doi:10.1034/j.1600-0706.2003.11680.x.
  • Aung, T. N., Z. Qu, R. D. Kortschak, and D. L. Adelson. 2017. Understanding the effectiveness of natural compound mixtures in cancer through their molecular mode of action. International Journal of Molecular Sciences 18 (3):656. doi:10.3390/ijms18030656.
  • Bai, Y., X. Chen, and H. Qi. 2022. Characterization and bioactivity of phlorotannin loaded protein-polysaccharide nanocomplexes. Lwt 155:112998. doi:10.1016/j.lwt.2021.112998.
  • Bai, Y., Y. Sun, Y. Gu, J. Zheng, C. Yu, and H. Qi. 2020. Preparation, characterization and antioxidant activities of kelp phlorotannin nanoparticles. Molecules 25 (19):4550. doi:10.3390/molecules25194550.
  • Baldrick, F. R., K. McFadden, M. Ibars, C. Sung, T. Moffatt, K. Megarry, K. Thomas, P. Mitchell, J. M. W. Wallace, L. K. Pourshahidi, et al. 2018. Impact of a (poly) phenol-rich extract from the brown algae Ascophyllum nodosum on DNA damage and antioxidant activity in an overweight or obese population: A randomized controlled trial. The American Journal of Clinical Nutrition 108 (4):688–700. doi:10.1093/ajcn/nqy147.
  • Banik, S., and A. Ghosh. 2021. The association of oxidative stress biomarkers with type 2 diabetes mellitus: A systematic review and meta-analysis. Health Science Reports 4 (4):e389. doi:10.1002/hsr2.389.
  • Baskararaj, S., T. Panneerselvam, S. Govindaraj, S. Arunachalam, P. Parasuraman, S. R. K. Pandian, M. Sankaranarayanan, U. P. Mohan, P. Palanisamy, V. Ravishankar, et al. 2020. Formulation and characterization of folate receptor-targeted PEGylated liposome encapsulating bioactive compounds from Kappaphycus alvarezii for cancer therapy. 3 Biotech 10 (3):136. doi:10.1007/s13205-020-2132-7.
  • Berglin, M., L. Delage, P. Potin, H. Vilter, and H. Elwing. 2004. Enzymatic cross-linking of a phenolic polymer extracted from the marine alga Fucus serratus. Biomacromolecules 5 (6):2376–83. doi:10.1021/bm0496864.
  • Bertoni, G. 2013. A key step in phlorotannin biosynthesis revealed. The Plant Cell 25 (8):2770. doi:10.1105/tpc.113.250813.
  • Bierie, B., and H. L. Moses. 2010. Transforming growth factor beta (TGF-β) and inflammation in cancer. Cytokine & Growth Factor Reviews 21 (1):49–59. doi:10.1016/j.cytogfr.2009.11.008.
  • Birkemeyer, C., V. Lemesheva, S. Billig, and E. Tarakhovskaya. 2020. Composition of intracellular and cell wall-bound phlorotannin fractions in fucoid algae indicates specific functions of these metabolites dependent on the chemical structure. Metabolites 10 (9):369. doi:10.3390/metabo10090369.
  • Blanz, M., P. Ascough, I. Mainland, P. Martin, M. A. Taggart, B. Dieterich, J. Wishart, K. L. Sayle, A. Raab, and J. Feldmann. 2019. Seaweed fertilisation impacts the chemical and isotopic composition of barley: Implications for analyses of archaeological skeletal remains. Journal of Archaeological Science 104:34–44. doi:10.1016/j.jas.2019.02.003.
  • Botelho, J., V. Machado, Y. Leira, L. Proença, and J. J. Mendes. 2021. Periodontal inflamed surface area mediates the link between homocysteine and high blood pressure. Biomolecules 11 (6):875. doi:10.3390/biom11060875.
  • Breijyeh, Z., B. Jubeh, and R. Karaman. 2020. Resistance of gram-negative bacteria to current antibacterial agents and approaches to resolve it. Molecules 25 (6):1340. doi:10.3390/molecules25061340.
  • Cáceres-Jiménez, S., J. L. Ordóñez-Díaz, J. M. Moreno-Rojas, and G. Pereira-Caro. 2023. 9 - Bioaccesibility and bioavailability of marine polyphenols. In Marine phenolic compounds, ed. J. R. Pérez Correa, R. Mateos, and H. Domínguez, 265–98. Netherlands: Elsevier.
  • Castro-Alves, V. C., and B. R. Cordenunsi. 2015. Total soluble phenolic compounds quantification is not as simple as it seems. Food Analytical Methods 8 (4):873–84. doi:10.1007/s12161-014-9961-0.
  • Catarino, M. D., S. J. Amarante, N. Mateus, A. M. Silva, and S. M. Cardoso. 2021. Brown algae phlorotannins: A marine alternative to break the oxidative stress, inflammation and cancer network. Foods 10 (7):1478. doi:10.3390/foods10071478.
  • Catarino, M. D., C. Marçal, T. Bonifácio-Lopes, D. Campos, N. Mateus, A. M. Silva, M. M. Pintado, and S. M. Cardoso. 2021. Impact of phlorotannin extracts from Fucus vesiculosus on human gut microbiota. Marine Drugs 19 (7):375. doi:10.3390/md19070375.
  • Catarino, M. D., S. M. Pires, S. Silva, F. Costa, S. S. Braga, D. C. Pinto, A. M. Silva, and S. M. Cardoso. 2022. Overview of phlorotannins’ constituents in fucales. Marine Drugs 20 (12):754. doi:10.3390/md20120754.
  • Catarino, M. D., A. Silva, M. T. Cruz, N. Mateus, A. M. Silva, and S. M. Cardoso. 2020. Phlorotannins from Fucus vesiculosus: Modulation of inflammatory response by blocking NF-κB signaling pathway. International Journal of Molecular Sciences 21 (18):6897. doi:10.3390/ijms21186897.
  • Charoensiddhi, S., R. E. Abraham, P. Su, and W. Zhang. 2020. Seaweed and seaweed-derived metabolites as prebiotics. Advances in Food and Nutrition Research 91:97–156.
  • Chen, J., Z. Zhou, P. Li, S. Ye, W. Li, M. Li, L. Zhu, and Y. Ding. 2023. Investigation of the potential phlorotannins and mechanism of six brown algae in treating type II diabetes mellitus based on biological activity, UPLC-QE-MS/MS, and network pharmacology. Foods 12 (16):3000. doi:10.3390/foods12163000.
  • Cho, H. M., T. P. Doan, T. K. Q. Ha, H. W. Kim, B. W. Lee, H. T. T. Pham, T. O. Cho, and W. K. Oh. 2019. Dereplication by high-performance liquid chromatography (HPLC) with quadrupole-time-of-flight mass spectroscopy (qTOF-MS) and antiviral activities of phlorotannins from Ecklonia cava. Marine Drugs 17 (3):149. doi:10.3390/md17030149.
  • Chopin, T., and A. G. Tacon. 2021. Importance of seaweeds and extractive species in global aquaculture production. Reviews in Fisheries Science & Aquaculture 29 (2):139–48. doi:10.1080/23308249.2020.1810626.
  • Chouh, A., T. Nouadri, M. D. Catarino, A. M. Silva, and S. M. Cardoso. 2022. Phlorotannins of the Brown algae Sargassum vulgare from the Mediterranean Sea coast. Antioxidants 11 (6):1055. doi:10.3390/antiox11061055.
  • Chowdhury, M. T. H., I. Bangoura, J.-Y. Kang, N.-G. Park, D.-H. Ahn, and Y.-K. Hong. 2011. Distribution of phlorotannins in the brown alga Ecklonia cava and comparison of pretreatments for extraction. Fisheries and Aquatic Sciences 14 (3):198–204. doi:10.5657/FAS.2011.0198.
  • Corona, G., M. M. Coman, Y. Guo, S. Hotchkiss, C. Gill, P. Yaqoob, J. P. Spencer, and I. Rowland. 2017. Effect of simulated gastrointestinal digestion and fermentation on polyphenolic content and bioactivity of brown seaweed phlorotannin-rich extracts. Molecular Nutrition & Food Research 61 (11):1700223. doi:10.1002/mnfr.201700223.
  • Corona, G., Y. Ji, P. Anegboonlap, S. Hotchkiss, C. Gill, P. Yaqoob, J. P. Spencer, and I. Rowland. 2016. Gastrointestinal modifications and bioavailability of brown seaweed phlorotannins and effects on inflammatory markers. The British Journal of Nutrition 115 (7):1240–53. doi:10.1017/S0007114516000210.
  • Cui, Y., J.-Y. Park, J. Wu, J. H. Lee, Y.-S. Yang, M.-S. Kang, S.-C. Jung, J. M. Park, E.-S. Yoo, S.-H. Kim, et al. 2015. Dieckol attenuates microglia-mediated neuronal cell death via ERK, Akt and NADPH oxidase-mediated pathways. The Korean Journal of Physiology & Pharmacology: Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology 19 (3):219–28. doi:10.4196/kjpp.2015.19.3.219.
  • Dal Canto, E., A. Ceriello, L. Rydén, M. Ferrini, T. B. Hansen, O. Schnell, E. Standl, and J. W. Beulens. 2019. Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications. European Journal of Preventive Cardiology 26 (2_suppl):25–32. doi:10.1177/2047487319878371.
  • Debbarma, J., P. Viji, B. M. Rao, and C. Ravishankar. 2022. Seaweeds: Potential applications of the aquatic vegetables to augment nutritional composition, texture, and health benefits of food and food products. In Sustainable global resources of seaweeds volume 2: Food, pharmaceutical and health applications, 3 54. Ranga Rao, A., & Ravishankar, G.A., Eds., Springer, Cham, Switzerland.
  • Deepika, C., J. Wolf, N. Moheimani, B. Hankamer, B. von Herzen, and A. R. Rao. 2022. Utilisation of seaweeds in the Australian market–commercialisation strategies: Current trends and future prospects. In Sustainable global resources of seaweeds volume 1: Bioresources, cultivation, trade and multifarious applications, 265–94. Ranga Rao, A., & Ravishankar, G.A., Ed., Springer, Cham, Switzerland.
  • Dong, X., Y. Bai, Z. Xu, Y. Shi, Y. Sun, S. Janaswamy, C. Yu, and H. Qi. 2019. Phlorotannins from Undaria pinnatifida sporophyll: Extraction, antioxidant, and anti-inflammatory activities. Marine Drugs 17 (8):434. doi:10.3390/md17080434.
  • Duarte, C. M., A. Bruhn, and D. Krause-Jensen. 2021. A seaweed aquaculture imperative to meet global sustainability targets. Nature Sustainability 5 (3):185–93. doi:10.1038/s41893-021-00773-9.
  • Dutot, M., R. Fagon, M. Hemon, and P. Rat. 2012. Antioxidant, anti-inflammatory, and anti-senescence activities of a phlorotannin-rich natural extract from brown seaweed Ascophyllum nodosum. Applied Biochemistry and Biotechnology 167 (8):2234–40. doi:10.1007/s12010-012-9761-1.
  • Elbialy, N. S., S. F. Aboushoushah, B. F. Sofi, and A. Noorwali. 2020. Multifunctional curcumin-loaded mesoporous silica nanoparticles for cancer chemoprevention and therapy. Microporous and Mesoporous Materials 291:109540. doi:10.1016/j.micromeso.2019.06.002.
  • El-Manaway, I. M., and S. H. Rashedy. 2022. The ecology and physiology of seaweeds: An overview. In Sustainable global resources of seaweeds volume 1: Bioresources, cultivation, trade and multifarious applications, 3–16. Ranga Rao, A., & Ravishankar, G.A., Eds., Springer, Cham, Switzerland.
  • Emeline, C. B., D. Ludovic, V. Laurent, L. Catherine, I. Kruse, A. G. Erwan, W. Florian, and P. Philippe. 2021. Induction of phlorotannins and gene expression in the brown macroalga Fucus vesiculosus in response to the herbivore Littorina littorea. Marine Drugs 19 (4):185. doi:10.3390/md19040185.
  • Erpel, F., C. Camilo, R. Mateos, and J. R. Pérez-Correa. 2023. A macroporous resin purification process to obtain food-grade phlorotannin-rich extracts with α-glucosidase inhibitory activity from Chilean brown seaweeds: An UHPLC-MSn profiling. Food Chemistry 402:134472. doi:10.1016/j.foodchem.2022.134472.
  • Erpel, F., R. Mateos, J. Pérez-Jiménez, and J. R. Pérez-Correa. 2020. Phlorotannins: From isolation and structural characterization, to the evaluation of their antidiabetic and anticancer potential. Food Research International 137:109589. doi:10.1016/j.foodres.2020.109589.
  • Falkowski, P. 2012. Ocean science: The power of plankton. Nature 483 (7387):S17–S20. doi:10.1038/483S17a.
  • FAO. 2018. The global status of seaweed production, trade and utilization. Globefish Research Programme 124:120. FAO: Rome.
  • FAO (Food and Agriculture Organization). 2022. The state of world fisheries and aquaculture. Towards blue transformation. Rome: FAO.
  • Feng, H., M. Li, Z. Xing, X-k Ouyang, and J. Ling. 2022. Efficient delivery of fucoxanthin using metal–polyphenol network-coated magnetic mesoporous silica. Journal of Drug Delivery Science and Technology 77:103842. doi:10.1016/j.jddst.2022.103842.
  • Fernando, I. P. S., W. Lee, and G. Ahn. 2022. Marine algal flavonoids and phlorotannins; an intriguing frontier of biofunctional secondary metabolites. Critical Reviews in Biotechnology 42 (1):23–45. doi:10.1080/07388551.2021.1922351.
  • Ferreira, C. A., A. P. Januário, R. Félix, N. Alves, M. F. Lemos, and J. R. Dias. 2021. Multifunctional gelatin/chitosan electrospun wound dressing dopped with Undaria pinnatifida phlorotannin-enriched extract for skin regeneration. Pharmaceutics 13 (12):2152. doi:10.3390/pharmaceutics13122152.
  • Ford, L., C. Curry, M. Campbell, K. Theodoridou, G. Sheldrake, J. Dick, L. Stella, and P. J. Walsh. 2020. Effect of phlorotannins from brown seaweeds on the in vitro digestibility of pig feed. Animals 10 (11):2193. doi:10.3390/ani10112193.
  • Ford, L., K. Theodoridou, G. N. Sheldrake, and P. J. Walsh. 2019. A critical review of analytical methods used for the chemical characterisation and quantification of phlorotannin compounds in brown seaweeds. Phytochemical Analysis: PCA 30 (6):587–99. doi:10.1002/pca.2851.
  • Garcia-Vaquero, M., R. Ravindran, O. Walsh, J. O’Doherty, A. K. Jaiswal, B. K. Tiwari, and G. Rajauria. 2021. Evaluation of ultrasound, microwave, ultrasound–microwave, hydrothermal and high pressure assisted extraction technologies for the recovery of phytochemicals and antioxidants from brown macroalgae. Marine Drugs 19 (6):309. doi:10.3390/md19060309.
  • Gheda, S., R. A. Hamouda, M. A. Naby, T. M. Mohamed, T. M. Al-Shaikh, and A. Khamis. 2023. Potent effect of phlorotannins derived from Sargassum linifolium as antioxidant and antidiabetic in a streptozotocin-induced diabetic rats model. Applied Sciences 13 (8):4711. doi:10.3390/app13084711.
  • Gheda, S., M. A. Naby, T. Mohamed, L. Pereira, and A. Khamis. 2021. Antidiabetic and antioxidant activity of phlorotannins extracted from the brown seaweed Cystoseira compressa in streptozotocin-induced diabetic rats. Environmental Science and Pollution Research 28 (18):22886–901. doi:10.1007/s11356-021-12347-5.
  • Ghosh, S., T. Sarkar, S. Pati, Z. A. Kari, H. A. Edinur, and R. Chakraborty. 2022. Novel bioactive compounds from marine sources as a tool for functional food development. Frontiers in Marine Science 9:76. doi:10.3389/fmars.2022.832957.
  • Glombitza, K.-W., and G. Gerstberger. 1985. Phlorotannins with dibenzodioxin structural elements from the brown alga Eisenia arborea. Phytochemistry 24 (3):543–51. doi:10.1016/S0031-9422(00)80764-5.
  • Glombitza, K.-W., and A. Schmidt. 1999. Nonhalogenated and halogenated phlorotannins from the brown alga Carpophyllum angustifolium. Journal of Natural Products 62 (9):1238–40. doi:10.1021/np990076c.
  • Gómez, I., and P. Huovinen. 2020. Brown algal phlorotannins: An overview of their functional roles. In Antarctic seaweeds: Diversity, adaptation and ecosystem services, 365–88. Gómez, I., & Huovinen, P., Eds., Springer, Cham, Switzerland.
  • Guan, L., H. Long, F. Ren, Y. Li, and H. Zhang. 2022. A structure—Activity relationship study of the inhibition of α-amylase by benzoic acid and its derivatives. Nutrients 14 (9):1931. doi:10.3390/nu14091931.
  • Guiry, M. D. 2012. How many species of algae are there? Journal of Phycology 48 (5):1057–63. doi:10.1111/j.1529-8817.2012.01222.x.
  • Gümüş Yılmaz, G., J. L. Gómez Pinchetti, A. Cifuentes, M. Herrero, and E. Ibáñez. 2019. Comparison of extraction techniques and surfactants for the isolation of total polyphenols and phlorotannins from the brown algae Lobophora variegata. Analytical Letters 52 (17):2724–40. doi:10.1080/00032719.2019.1597878.
  • Gunathilaka, T., L. R. Keertihirathna, and D. Peiris. 2021. Advanced pharmacological uses of marine algae as an anti-diabetic therapy. In Natural Medicinal Plants, 79–95. El-Shemy, H., IntechOpen, London, UK.
  • Gupta, V., S. Bhavanasi, M. Quadir, K. Singh, G. Ghosh, K. Vasamreddy, A. Ghosh, T. J. Siahaan, S. Banerjee, and S. K. Banerjee. 2019. Protein PEGylation for cancer therapy: Bench to bedside. Journal of Cell Communication and Signaling 13 (3):319–30. doi:10.1007/s12079-018-0492-0.
  • Ha, J. W., H. Song, S. S. Hong, and Y. C. Boo. 2019. Marine alga Ecklonia cava extract and dieckol attenuate prostaglandin E2 production in HaCaT keratinocytes exposed to airborne particulate matter. Antioxidants 8 (6):190. doi:10.3390/antiox8060190.
  • Han, E. J., H.-S. Kim, K. Sanjeewa, K. Herath, Y.-J. Jeon, Y. Jee, J. Lee, T. Kim, S.-Y. Shim, and G. Ahn. 2020. Eckol from Ecklonia cava suppresses immunoglobulin E-mediated mast cell activation and passive cutaneous anaphylaxis in mice. Nutrients 12 (5):1361. doi:10.3390/nu12051361.
  • Hari, S. K., A. Gauba, N. Shrivastava, R. M. Tripathi, S. K. Jain, and A. K. Pandey. 2023. Polymeric micelles and cancer therapy: An ingenious multimodal tumor-targeted drug delivery system. Drug Delivery and Translational Research 13 (1):135–63. doi:10.1007/s13346-022-01197-4.
  • Heo, S.-J., S.-H. Cha, K.-N. Kim, S.-H. Lee, G. Ahn, D.-H. Kang, C. Oh, Y.-U. Choi, A. Affan, D. Kim, et al. 2012. Neuroprotective effect of phlorotannin isolated from Ishige okamurae against H 2 O 2-induced oxidative stress in murine hippocampal neuronal cells, HT22. Applied Biochemistry and Biotechnology 166 (6):1520–32. doi:10.1007/s12010-012-9545-7.
  • Hermund, D. B., H. Torsteinsen, J. Vega, F. L. Figueroa, and C. Jacobsen. 2022. Screening for new cosmeceuticals from brown algae Fucus vesiculosus with antioxidant and photo-protecting properties. Marine Drugs 20 (11):687. doi:10.3390/md20110687.
  • Hessami, M. J., A. R. Rao, and G. A. Ravishankar. 2019. Opportunities and challenges in seaweeds as feed stock for biofuel production. In Handbook of algal technologies and phytochemicals, 39–50. Ravishankar, G. A, & Ambati, R.R., Eds., CRC Press, USA.
  • Hierholtzer, A., L. Chatellard, M. Kierans, J. C. Akunna, and P. J. Collier. 2013. The impact and mode of action of phenolic compounds extracted from brown seaweed on mixed anaerobic microbial cultures. Journal of Applied Microbiology 114 (4):964–73. doi:10.1111/jam.12114.
  • Hodhodi, A., A. Babakhani, and H. Rostamzad. 2022. Effect of different extraction conditions on phlorotannin content and antioxidant activity of extract from brown algae (Sargassum angustifolium). Journal of Food Processing and Preservation 46 (3):e16307. doi:10.1111/jfpp.16307.
  • Hu, C., and S. Ma. 2018. Recent development of lipoxygenase inhibitors as anti-inflammatory agents. MedChemComm 9 (2):212–25. doi:10.1039/c7md00390k.
  • Iken, K., C. D. Amsler, J. M. Hubbard, J. B. McClintock, and B. J. Baker. 2007. Allocation patterns of phlorotannins in Antarctic brown algae. Phycologia 46 (4):386–95. doi:10.2216/06-67.1.
  • Im, J., C. H. Choi, F. Mun, J. Lee, H. Kim, W.-K. Jung, C. H. Jang, and G. Kim. 2017. A polycaprolactone/fish collagen/alginate biocomposite supplemented with phlorotannin for hard tissue regeneration. RSC Advances 7 (4):2009–18. doi:10.1039/C6RA25182J.
  • Ismail, M. M., G. M. El Zokm, A. M. El Sikaily, A. I. Selim, and G. A. Ismail. 2023. Chemodiversity and bioactivity assessment of phlorotannins from some Phaeophyta species from the Red Sea. Journal of Applied Phycology 35 (4):1769–88. doi:10.1007/s10811-023-03000-4.
  • Jégou, C., N. Kervarec, S. Cérantola, I. Bihannic, and V. Stiger-Pouvreau. 2015. NMR use to quantify phlorotannins: The case of Cystoseira tamariscifolia, a phloroglucinol-producing brown macroalga in Brittany (France). Talanta 135:1–6. doi:10.1016/j.talanta.2014.11.059.
  • Jun, Y.-J., M. Lee, T. Shin, N. Yoon, J.-H. Kim, and H.-R. Kim. 2014. Eckol enhances heme oxygenase-1 expression through activation of Nrf2/JNK pathway in HepG2 cells. Molecules 19 (10):15638–52. doi:10.3390/molecules191015638.
  • Junning, C., and Giulia, G. 2021. Global seaweeds and microalgae production, 1950–2019. Food and Agriculture Organization of the United Nations, Rome.
  • Kalyane, D., N. Raval, R. Maheshwari, V. Tambe, K. Kalia, and R. K. Tekade. 2019. Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer. Materials Science & Engineering. C, Materials for Biological Applications 98:1252–76. doi:10.1016/j.msec.2019.01.066.
  • Kang, M.-C., W. A. J. P. Wijesinghe, S.-H. Lee, S.-M. Kang, S.-C. Ko, X. Yang, N. Kang, B.-T. Jeon, J. Kim, D.-H. Lee, et al. 2013. Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model. Food and Chemical Toxicology 53:294–8. doi:10.1016/j.fct.2012.12.012.
  • Karonen, M. 2022. Insights into polyphenol–lipid interactions: Chemical methods, molecular aspects and their effects on membrane structures. Plants 11 (14):1809. doi:10.3390/plants11141809.
  • Karthikeyan, A., A. Joseph, and B. G. Nair. 2022. Promising bioactive compounds from the marine environment and their potential effects on various diseases. Journal of Genetic Engineering and Biotechnology 20 (1):1–38. doi:10.1186/s43141-021-00290-4.
  • Kellogg, J., M. H. Grace, and M. A. Lila. 2014. Phlorotannins from Alaskan seaweed inhibit carbolytic enzyme activity. Marine Drugs 12 (10):5277–94. doi:10.3390/md12105277.
  • Kierstead, P. H., H. Okochi, V. J. Venditto, T. C. Chuong, S. Kivimae, J. M. Fréchet, and F. C. Szoka. 2015. The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes. Journal of Controlled Release 213:1–9. doi:10.1016/j.jconrel.2015.06.023.
  • Kim, A. D., K. A. Kang, M. J. Piao, K. C. Kim, J. Zheng, C. W. Yao, J. W. Cha, C. L. Hyun, H. K. Kang, N. H. Lee, et al. 2014. Cytoprotective effect of Eckol against oxidative stress-induced mitochondrial dysfunction: Involvement of the Foxo3a/Ampk pathway. Journal of Cellular Biochemistry 115 (8):1403–11. doi:10.1002/jcb.24790.
  • Kim, H.-J., C. Dasagrandhi, S.-H. Kim, B.-G. Kim, S.-H. Eom, and Y.-M. Kim. 2018. In vitro antibacterial activity of phlorotannins from edible brown algae, Eisenia bicyclis against streptomycin-resistant Listeria monocytogenes. Indian Journal of Microbiology 58 (1):105–8. doi:10.1007/s12088-017-0693-x.
  • Kim, K. C., K. A. Kang, R. Zhang, M. J. Piao, G. Y. Kim, M. Y. Kang, S. J. Lee, N. H. Lee, Y.-J. Surh, and J. W. Hyun. 2010. Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt. The International Journal of Biochemistry & Cell Biology 42 (2):297–305. doi:10.1016/j.biocel.2009.11.009.
  • Kim, S., S.-S. Kang, S.-I. Choi, G.-H. Kim, and J.-Y. Imm. 2019. Ecklonia cava extract containing dieckol suppresses RANKL-induced osteoclastogenesis via MAP kinase/NF-κB pathway inhibition and heme oxygenase-1 induction. Journal of Microbiology and Biotechnology 29 (1):11–20.
  • Koivikko, R., J. Eränen, J. Loponen, and V. Jormalainen. 2008. Variation of phlorotannins among three populations of Fucus vesiculosus as revealed by HPLC and colorimetric quantification. Journal of Chemical Ecology 34 (1):57–64. doi:10.1007/s10886-007-9410-2.
  • Kord, A., Y. Foudil-Cherif, M. Amiali, A. Boumechhour, and R. Benfares. 2021. Phlorotannins composition, radical scavenging capacity and reducing power of phenolics from the brown alga Cystoseira sauvageauana. Journal of Aquatic Food Product Technology 30 (4):426–38. doi:10.1080/10498850.2021.1895392.
  • Koren, S., and I. G. Fantus. 2007. Inhibition of the protein tyrosine phosphatase PTP1B: Potential therapy for obesity, insulin resistance and type-2 diabetes mellitus. Best Practice & Research. Clinical Endocrinology & Metabolism 21 (4):621–40. doi:10.1016/j.beem.2007.08.004.
  • Kumar, L. R., P. T. Paul, K. Anas, C. Tejpal, N. Chatterjee, T. Anupama, S. Mathew, and C. Ravishankar. 2022. Phlorotannins–Bioactivity and extraction perspectives. Journal of Applied Phycology 34 (4):2173–85. doi:10.1007/s10811-022-02749-4.
  • Kurihara, H., R. Konno, and K. Takahashi. 2015. Fucophlorethol C, a phlorotannin as a lipoxygenase inhibitor. Bioscience, Biotechnology, and Biochemistry 79 (12):1954–6. doi:10.1080/09168451.2015.1062716.
  • Le, Q.-T., Y. Li, Z.-J. Qian, M.-M. Kim, and S.-K. Kim. 2009. Inhibitory effects of polyphenols isolated from marine alga Ecklonia cava on histamine release. Process Biochemistry 44 (2):168–76. doi:10.1016/j.procbio.2008.10.002.
  • Lee, H.-A., J.-H. Lee, and J.-S. Han. 2017. A phlorotannin constituent of Ecklonia cava alleviates postprandial hyperglycemia in diabetic mice. Pharmaceutical Biology 55 (1):1149–54. doi:10.1080/13880209.2017.1291693.
  • Lee, S.-H., S.-C. Ko, M.-C. Kang, D. H. Lee, and Y.-J. Jeon. 2016. Octaphlorethol A, a marine algae product, exhibits antidiabetic effects in type 2 diabetic mice by activating AMP-activated protein kinase and upregulating the expression of glucose transporter 4. Food and Chemical Toxicology 91:58–64. doi:10.1016/j.fct.2016.02.022.
  • Le Lann, K., G. Surget, C. Couteau, L. Coiffard, S. Cérantola, F. Gaillard, M. Larnicol, M. Zubia, F. Guérard, N. Poupart, et al. 2016. Sunscreen, antioxidant, and bactericide capacities of phlorotannins from the brown macroalga Halidrys siliquosa. Journal of Applied Phycology 28 (6):3547–59. doi:10.1007/s10811-016-0853-0.
  • Lemesheva, V., C. Birkemeyer, D. Garbary, and E. Tarakhovskaya. 2020. Vanadium-dependent haloperoxidase activity and phlorotannin incorporation into the cell wall during early embryogenesis of Fucus vesiculosus (Phaeophyceae). European Journal of Phycology 55 (3):275–84. doi:10.1080/09670262.2019.1709131.
  • Li, C., B. Li, C. Zhu, and X. Meng. 2020. Modeling and optimization of tea polyphenol-alginate/chitosan magnetic microcapsules. Journal of Molecular Structure 1208:127827. doi:10.1016/j.molstruc.2020.127827.
  • Li, Y., X. Fu, D. Duan, X. Liu, J. Xu, and X. Gao. 2017. Extraction and identification of phlorotannins from the brown alga, Sargassum fusiforme (Harvey) Setchell. Marine Drugs 15 (2):49. doi:10.3390/md15020049.
  • Li, Y., M. Kröger, and W. K. Liu. 2014. Endocytosis of PEGylated nanoparticles accompanied by structural and free energy changes of the grafted polyethylene glycol. Biomaterials 35 (30):8467–78. doi:10.1016/j.biomaterials.2014.06.032.
  • Li, Y., S.-H. Lee, Q.-T. Le, M.-M. Kim, and S.-K. Kim. 2008. Anti-allergic effects of phlorotannins on histamine release via binding inhibition between IgE and FcεRI. Journal of Agricultural and Food Chemistry 56 (24):12073–80. doi:10.1021/jf802732n.
  • Liu, X., and C. L. Bourvellec. 2023. 7 - Interactions with other macromolecules. In Marine phenolic compounds, ed. J. R. Pérez-Correa, R. Mateos, and H. Domínguez, 219–38. Elsevier, Netherlands.
  • Liu, X., W. Yuan, R. Sharma-Shivappa, and J. van Zanten. 2017. Antioxidant activity of phlorotannins from brown algae. International Journal of Agricultural and Biological Engineering 10 (6):184–91. doi:10.25165/j.ijabe.20171006.2854.
  • Lobine, D., K. R. Rengasamy, and M. F. Mahomoodally. 2022. Functional foods and bioactive ingredients harnessed from the ocean: Current status and future perspectives. Critical Reviews in Food Science and Nutrition 62 (21):5794–823. doi:10.1080/10408398.2021.1893643.
  • Lopes, G., M. Barbosa, P. B. Andrade, and P. Valentão. 2019. Phlorotannins from Fucales: Potential to control hyperglycemia and diabetes-related vascular complications. Journal of Applied Phycology 31 (5):3143–52. doi:10.1007/s10811-019-01816-7.
  • Lopes, G., E. Pinto, P. B. Andrade, and P. Valentao. 2013. Antifungal activity of phlorotannins against dermatophytes and yeasts: Approaches to the mechanism of action and influence on Candida albicans virulence factor. PLoS One 8 (8):e72203. doi:10.1371/journal.pone.0072203.
  • Lopes, G., C. Sousa, L. R. Silva, E. Pinto, P. B. Andrade, J. Bernardo, T. Mouga, and P. Valentão. 2012. Can phlorotannins purified extracts constitute a novel pharmacological alternative for microbial infections with associated inflammatory conditions? PLoS One 7 (2):e31145. doi:10.1371/journal.pone.0031145.
  • Lo Piparo, E., H. Scheib, N. Frei, G. Williamson, M. Grigorov, and C. J. Chou. 2008. Flavonoids for controlling starch digestion: Structural requirements for inhibiting human α-amylase. Journal of Medicinal Chemistry 51 (12):3555–61. doi:10.1021/jm800115x.
  • Magarkar, A., E. Karakas, M. Stepniewski, T. Rog, and A. Bunker. 2012. Molecular dynamics simulation of PEGylated bilayer interacting with salt ions: A model of the liposome surface in the bloodstream. The Journal of Physical Chemistry. B 116 (14):4212–9. doi:10.1021/jp300184z.
  • Mandola, A., A. Nozawa, and T. Eiwegger. 2019. Histamine, histamine receptors, and anti-histamines in the context of allergic responses. LymphoSign Journal 6 (2):35–51. doi:10.14785/lymphosign-2018-0016.
  • Margraf, T., A. R. Karnopp, N. D. Rosso, and D. Granato. 2015. Comparison between Folin-Ciocalteu and Prussian Blue assays to estimate the total phenolic content of juices and teas using 96-well microplates. Journal of Food Science 80 (11):C2397–C2403. doi:10.1111/1750-3841.13077.
  • Matsui, T., C. Ito, M. Itoigawa, and T. Shibata. 2022. Three phlorotannins from Sargassum carpophyllum are effective against the secretion of allergic mediators from antigen-stimulated rat basophilic leukemia cells. Food Chemistry 377:131992. doi:10.1016/j.foodchem.2021.131992.
  • Meng, W., T. Mu, H. Sun, and M. Garcia-Vaquero. 2021. Phlorotannins: A review of extraction methods, structural characteristics, bioactivities, bioavailability, and future trends. Algal Research 60:102484. doi:10.1016/j.algal.2021.102484.
  • Meshalkina, D., E. Tsvetkova, A. Orlova, R. Islamova, M. Grashina, D. Gorbach, V. Babakov, A. Francioso, C. Birkemeyer, L. Mosca, et al. 2023. First insight into the neuroprotective and antibacterial effects of phlorotannins isolated from the cell walls of brown algae Fucus vesiculosus and Pelvetia canaliculata. Antioxidants 12 (3):696. doi:10.3390/antiox12030696.
  • Meslet-Cladière, L., L. Delage, C. J.-J. Leroux, S. Goulitquer, C. Leblanc, E. Creis, E. A. Gall, V. Stiger-Pouvreau, M. Czjzek, and P. Potin. 2013. Structure/function analysis of a type III polyketide synthase in the brown alga Ectocarpus siliculosus reveals a biochemical pathway in phlorotannin monomer biosynthesis. The Plant Cell 25 (8):3089–103. doi:10.1105/tpc.113.111336.
  • Mirchandani, Y., V. B. Patravale, and S. Brijesh. 2021. Solid lipid nanoparticles for hydrophilic drugs. Journal of Controlled Release 335:457–64. doi:10.1016/j.jconrel.2021.05.032.
  • Mittal, A., I. Roy, and S. Gandhi. 2022. Magnetic nanoparticles: An overview for biomedical applications. Magnetochemistry 8 (9):107. doi:10.3390/magnetochemistry8090107.
  • Moheimanian, N., H. Mirkhani, A. Purkhosrow, J. Sohrabipour, and A. R. Jassbi. 2023. In vitro and in vivo antidiabetic, α-glucosidase inhibition and antibacterial activities of three brown algae, Polycladia myrica, Padina antillarum, and Sargassum boveanum, and a red alga, Palisada perforata from the Persian Gulf. Innovative Journal of Pharmaceutical Research 22 (1):e133731.
  • Morrison, D. K. 2012. MAP kinase pathways. Cold Spring Harbor Perspectives in Biology 4 (11):a011254. doi:10.1101/cshperspect.a011254.
  • Mozafari, M. R. 2010. Nanoliposomes: Preparation and analysis. In Liposomes: Methods and protocols, volume 1: Pharmaceutical nanocarriers, 29–50. Weissig, V., Ed., Human Press, Totowa, NJ, USA.
  • Muhammad, K., J. Zhao, I. Ullah, J. Guo, X-k Ren, and Y. Feng. 2019. Ligand targeting and peptide functionalized polymers as non-viral carriers for gene therapy. Biomaterials Science 8 (1):64–83. doi:10.1039/c9bm01112a.
  • Murray, M., A. L. Dordevic, K. Cox, A. Scholey, L. Ryan, and M. P. Bonham. 2021. Twelve weeks’ treatment with a polyphenol-rich seaweed extract increased HDL cholesterol with no change in other biomarkers of chronic disease risk in overweight adults: A placebo-controlled randomized trial. The Journal of Nutritional Biochemistry 96:108777. doi:10.1016/j.jnutbio.2021.108777.
  • Murray, M., A. L. Dordevic, L. Ryan, and M. P. Bonham. 2019. A single-dose of a polyphenol-rich Fucus vesiculosus extract is insufficient to blunt the elevated postprandial blood glucose responses exhibited by healthy adults in the evening: A randomised crossover trial. Antioxidants 8 (2):49. doi:10.3390/antiox8020049.
  • Nakamura, T., S. Maeda, K. Horiguchi, T. Maehara, K. Aritake, B-i Choi, Y. Iwakura, Y. Urade, and T. Murata. 2015. PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia. Nature Communications 6 (1):7514. doi:10.1038/ncomms8514.
  • Nazzaro, F., F. Fratianni, A. d’Acierno, V. De Feo, F. J. Ayala-Zavala, A. Gomes-Cruz, D. Granato, and R. Coppola. 2019. Effect of polyphenols on microbial cell-cell communications. In Quorum sensing, 195–223. Tommonaro, G., Ed., Academic Press, Netherlands.
  • Obluchinskaya, E. D., A. Daurtseva, O. Pozharitskaya, E. Flisyuk, and A. Shikov. 2019. Natural deep eutectic solvents as alternatives for extracting phlorotannins from brown algae. Pharmaceutical Chemistry Journal 53 (3):243–7. doi:10.1007/s11094-019-01987-0.
  • Obluchinskaya, E. D., O. N. Pozharitskaya, D. V. Zakharov, E. V. Flisyuk, I. I. Terninko, Y. E. Generalova, I. E. Smekhova, and A. N. Shikov. 2022. The biochemical composition and antioxidant properties of Fucus vesiculosus from the Arctic region. Marine Drugs 20 (3):193. doi:10.3390/md20030193.
  • Park, E., H. Yu, J.-H. Lim, J. H. Choi, K.-J. Park, and J. Lee. 2023. Seaweed metabolomics: A review on its nutrients, bioactive compounds and changes in climate change. Food Research International 163:112221. doi:10.1016/j.foodres.2022.112221.
  • Park, J.-Y., J. H. Kim, J. M. Kwon, H.-J. Kwon, H. J. Jeong, Y. M. Kim, D. Kim, W. S. Lee, and Y. B. Ryu. 2013. Dieckol, a SARS-CoV 3CLpro inhibitor, isolated from the edible brown algae Ecklonia cava. Bioorganic & Medicinal Chemistry 21 (13):3730–7. doi:10.1016/j.bmc.2013.04.026.
  • Patel, A. K., A. P. Vadrale, R. R. Singhania, P. Michaud, A. Pandey, S.-J. Chen, C.-W. Chen, and C.-D. Dong. 2023. Algal polysaccharides: Current status and future prospects. Phytochemistry Reviews 22 (4):1167–96. doi:10.1007/s11101-021-09799-5.
  • Pelletreau, K. N. 2008. The application of molecular tools towards the study of brown algal chemical ecology and the production of phlorotannins. University of Delaware, USA.
  • Pereira, L. 2016. Edible seaweeds of the world, CRC Press, Boca Raton, USA.
  • Petchidurai, G., J. A. Nagoth, M. S. John, K. Sahayaraj, N. Murugesan, and S. Pucciarelli. 2019. Standardization and quantification of total tannins, condensed tannin and soluble phlorotannins extracted from thirty-two drifted coastal macroalgae using high performance liquid chromatography. Bioresource Technology Reports 7:100273. doi:10.1016/j.biteb.2019.100273.
  • Phang, S. J., H. X. Teh, M. L. Looi, B. Arumugam, M. B. Fauzi, and U. R. Kuppusamy. 2023. Phlorotannins from brown algae: A review on their antioxidant mechanisms and applications in oxidative stress-mediated diseases. Journal of Applied Phycology 35 (2):867–92. doi:10.1007/s10811-023-02913-4.
  • Phang-Lyn, S., and V. A. Llerena. 2019. Biochemistry, biotransformation, StatPearls, Treasure Island, FL.
  • Phasanasophon, K., and S. M. Kim. 2019. Anti-inflammatory activity of the phlorotannin trifuhalol A using LPS-stimulated RAW264. 7 cells through NF-κB and MAPK main signaling pathways. Natural Product Communications 14 (5):1934578X19849798. doi:10.1177/1934578X19849798.
  • Pradhan, B., R. Nayak, P. P. Bhuyan, S. Patra, C. Behera, S. Sahoo, J.-S. Ki, A. Quarta, A. Ragusa, and M. Jena. 2022. Algal phlorotannins as novel antibacterial agents with reference to the antioxidant modulation: Current advances and future directions. Marine Drugs 20 (6):403. doi:10.3390/md20060403.
  • Price, G., and D. A. Patel. 2021. Drug bioavailability. In StatPearls [Internet]. Statpearls Publishing, Treasure Island, FL.
  • Priya, S., V. M. Desai, and G. Singhvi. 2023. Surface modification of lipid-based nanocarriers: A potential approach to enhance targeted drug delivery. ACS Omega 8 (1):74–86. doi:10.1021/acsomega.2c05976.
  • Raja, R., S. Hemaiswarya, K. Arunkumar, N. Mathiyazhagan, S. Kandasamy, A. Arun, and P. Ramasamy. 2023. Efficacy of Eisenia bicyclis phlorotannins in the treatment of diabetes and reducing inflammation. Food Bioscience 52:102381. doi:10.1016/j.fbio.2023.102381.
  • Rajan, D. K., K. Mohan, S. Zhang, and A. R. Ganesan. 2021. Dieckol: A brown algal phlorotannin with biological potential. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 142:111988. doi:10.1016/j.biopha.2021.111988.
  • Ramya, S., S. Thiruvenkataswamy, K. Kavithaa, S. Preethi, H. Winster, V. Balachander, M. Paulpandi, and A. Narayanasamy. 2021. pH dependent drug release of Silibinin, a polyphenol conjugated with magnetic nanoparticle against the human colon cancer cell. Journal of Cluster Science 32 (2):305–17. doi:10.1007/s10876-020-01789-5.
  • Romagnoli, C., F., D’Asta, and M. L. Brandi. 2013. Drug delivery using composite scaffolds in the context of bone tissue engineering. Clinical Cases in Mineral and Bone Metabolism 10 (3):155.
  • Sailler, B., and K. W. Glombitza. 1999. Halogenated phlorethols and fucophlorethols from the brown alga Cystophora retroflexa. Natural Toxins 7 (2):57–62. doi:10.1002/(SICI)1522-7189(199903/04)7:2<57::AID-NT42>3.0.CO;2-F.
  • Sanadgol, N., and J. Wackerlig. 2020. Developments of smart drug-delivery systems based on magnetic molecularly imprinted polymers for targeted cancer therapy: A short review. Pharmaceutics 12 (9):831. doi:10.3390/pharmaceutics12090831.
  • Sancini, G., M. Gregori, E. Salvati, I. Cambianica, F. Re, F. Ornaghi, M. Canovi, C. Fracasso, A. Cagnotto, and M. Colombo. 2013. Functionalization with TAT-peptide enhances blood-brain barrier crossing in vitro of nanoliposomes carrying a curcumin-derivative to bind amyloid-β peptide. Journal of Nanomedicine & Nanotechnology 04 (03):1–8. doi:10.4172/2157-7439.1000171.
  • Sathya, R., N. Kanaga, P. Sankar, and S. Jeeva. 2017. Antioxidant properties of phlorotannins from brown seaweed Cystoseira trinodis (Forsskål) C. Agardh. Arabian Journal of Chemistry 10:S2608–S2614. doi:10.1016/j.arabjc.2013.09.039.
  • Savaghebi, D., M. Barzegar, and M. R. Mozafari. 2020. Manufacturing of nanoliposomal extract from Sargassum boveanum algae and investigating its release behavior and antioxidant activity. Food Science & Nutrition 8 (1):299–310. doi:10.1002/fsn3.1306.
  • Savaghebi, D., M. Ghaderi-Ghahfarokhi, and M. Barzegar. 2021. Encapsulation of Sargassum boveanum algae extract in nano-liposomes: Application in functional mayonnaise production. Food and Bioprocess Technology 14 (7):1311–25. doi:10.1007/s11947-021-02638-7.
  • Schaffenburg, W. C., B. N. Lockshin, and C. M. C. DeKlotz. 2021. 3 - Polymorphisms: Why individual drug responses vary. In Comprehensive dermatologic drug therapy, ed. Stephen E. Wolverton, 21–33.e2. 4th ed. Elsevier, Netherlands.
  • Schoenwaelder, M. E., and M. N. Clayton. 2000. Physode formation in embryos of Phyllospora comosa and Hormosira banksii (Phaeophyceae). Phycologia 39 (1):1–9. doi:10.2216/i0031-8884-39-1-1.1.
  • Shahidi, F., and H. Peng. 2018. Bioaccessibility and bioavailability of phenolic compounds. Journal of Food Bioactives 4:11–68. doi:10.31665/JFB.2018.4162.
  • Shannon, E., and N. Abu-Ghannam. 2019. Seaweeds as nutraceuticals for health and nutrition. Phycologia 58 (5):563–77. doi:10.1080/00318884.2019.1640533.
  • Shen, Z., H. Ye, M. Kröger, and Y. Li. 2018. Aggregation of polyethylene glycol polymers suppresses receptor-mediated endocytosis of PEGylated liposomes. Nanoscale 10 (9):4545–60. doi:10.1039/c7nr09011k.
  • Shim, S. Y., M. Lee, and K. D. Lee. 2016. Achyranthes japonica Nakai water extract suppresses binding of IgE antibody to cell surface FcɛRI. Preventive Nutrition and Food Science 21 (4):323–9. doi:10.3746/pnf.2016.21.4.323.
  • Shrestha, S., W. Zhang, and S. Smid. 2021. Phlorotannins: A review on biosynthesis, chemistry and bioactivity. Food Bioscience 39:100832. doi:10.1016/j.fbio.2020.100832.
  • Shrivastava, A. K., and A. Pandey. 2013. Inflammation and rheumatoid arthritis. Journal of Physiology and Biochemistry 69 (2):335–47. doi:10.1007/s13105-012-0216-5.
  • Singh, I. P., and J. Sidana. 2013. 5 - Phlorotannins. In Functional ingredients from algae for foods and nutraceuticals, ed. H. Domínguez, 181–204. Woodhead Publishing, Cambridge, UK.
  • Sinha, A., and S. PK. 2019. Enhanced induction of apoptosis in HaCaT cells by luteolin encapsulated in PEGylated liposomes—role of caspase-3/caspase-14. Applied Biochemistry and Biotechnology 188 (1):147–64. doi:10.1007/s12010-018-2907-z.
  • Siriwardhana, N., K.-W. Lee, and Y.-J. Jeon. 2005. Radical scavenging potential of hydrophilic phlorotannins of Hizikia fusiformis. Algae 20 (1):69–75. doi:10.4490/ALGAE.2005.20.1.069.
  • Son, M., S. Oh, H. S. Lee, D.-M. Chung, J. T. Jang, Y.-J. Jeon, C. H. Choi, K. Y. Park, K. H. Son, and K. Byun. 2019. Ecklonia cava extract attenuates endothelial cell dysfunction by modulation of inflammation and brown adipocyte function in perivascular fat tissue. Nutrients 11 (11):2795. doi:10.3390/nu11112795.
  • Spiller, F., R. O. Formiga, J. F. da Silva Coimbra, J. C. Alves-Filho, T. M. Cunha, and F. Q. Cunha. 2019. Targeting nitric oxide as a key modulator of sepsis, arthritis and pain. Nitric Oxide: Biology and Chemistry 89:32–40. doi:10.1016/j.niox.2019.04.011.
  • Subbiah, V., X. Duan, O. T. Agar, F. R. Dunshea, C. J. Barrow, and H. A. Suleria. 2023. Comparative study on the effect of different drying techniques on phenolic compounds in Australian beach-cast brown seaweeds. Algal Research 72:103140. doi:10.1016/j.algal.2023.103140.
  • Subbiah, V., F. Ebrahimi, O. T. Agar, F. R. Dunshea, C. J. Barrow, and H. A. Suleria. 2023. Comparative study on the effect of phenolics and their antioxidant potential of freeze-dried Australian beach-cast seaweed species upon different extraction methodologies. Pharmaceuticals 16 (5):773. doi:10.3390/ph16050773.
  • Subbiah, V., C. Xie, F. R. Dunshea, C. J. Barrow, and H. A. Suleria. 2023. The quest for phenolic compounds from seaweed: Nutrition, biological activities and applications. Food Reviews International 39 (8):5786–813. doi:10.1080/87559129.2022.2094406.
  • Sugiura, Y., M. Usui, H. Katsuzaki, K. Imai, M. Kakinuma, H. Amano, and M. Miyata. 2018. Orally administered phlorotannins from Eisenia arborea suppress chemical mediator release and cyclooxygenase-2 signaling to alleviate mouse ear swelling. Marine Drugs 16 (8):267. doi:10.3390/md16080267.
  • Sugiura, Y., M. Usui, H. Katsuzaki, K. Imai, and M. Miyata. 2017. Anti-inflammatory effects of 6, 6′-bieckol and 6, 8′-bieckol from Eisenia arborea on mouse ear swelling. Food Science and Technology Research 23 (3):475–80. doi:10.3136/fstr.23.475.
  • Sugiura, Y., M. Usui, H. Katsuzaki, K. Imai, R. Tanaka, T. Matsushita, and M. Miyata. 2021. Dieckol isolated from a brown alga, Eisenia nipponica, suppresses ear swelling from allergic inflammation in mouse. Journal of Food Biochemistry 45 (4):e13659. doi:10.1111/jfbc.13659.
  • Sun, X., Y. Luo, L. Huang, B.-Y. Yu, and J. Tian. 2017. A peptide-decorated and curcumin-loaded mesoporous silica nanomedicine for effectively overcoming multidrug resistance in cancer cells. RSC Advances 7 (27):16401–9. doi:10.1039/C7RA01128H.
  • Surendhiran, D., H. Cui, and L. Lin. 2019. Encapsulation of phlorotannin in alginate/PEO blended nanofibers to preserve chicken meat from Salmonella contaminations. Food Packaging and Shelf Life 21:100346. doi:10.1016/j.fpsl.2019.100346.
  • Tanaka, K., M. Ohno, and D. B. Largo. 2020. An update on the seaweed resources of Japan. Botanica Marina 63 (1):105–17. doi:10.1515/bot-2018-0100.
  • Tang, J., W. Wang, and W. Chu. 2020. Antimicrobial and anti-quorum sensing activities of phlorotannins from seaweed (Hizikia fusiforme). Frontiers in Cellular and Infection Microbiology 10:586750. doi:10.3389/fcimb.2020.586750.
  • Tong, T., X. Liu, and C. Yu. 2021. Extraction and nano-sized delivery systems for phlorotannins to improve its bioavailability and bioactivity. Marine Drugs 19 (11):625. doi:10.3390/md19110625.
  • Turck, D., J.-L. Bresson, B. Burlingame, T. Dean, S. Fairweather-Tait, M. Heinonen, K. I. Hirsch-Ernst, I. Mangelsdorf, H. J. McArdle, A. Naska, et al. 2017. Safety of Ecklonia cava phlorotannins as a novel food pursuant to Regulation (EC) No 258/97. EFSA Journal. European Food Safety Authority 15 (10):e05003. doi:10.2903/j.efsa.2017.5003.
  • Um, M. Y., J. Y. Kim, J. K. Han, J. Kim, H. Yang, M. Yoon, J. Kim, S. W. Kang, and S. Cho. 2018. Phlorotannin supplement decreases wake after sleep onset in adults with self-reported sleep disturbance: A randomized, controlled, double-blind clinical and polysomnographic study. Phytotherapy Research: PTR 32 (4):698–704. doi:10.1002/ptr.6019.
  • Ummat, V., B. K. Tiwari, A. K. Jaiswal, K. Condon, M. Garcia-Vaquero, J. O’Doherty, C. O’Donnell, and G. Rajauria. 2020. Optimisation of ultrasound frequency, extraction time and solvent for the recovery of polyphenols, phlorotannins and associated antioxidant activity from brown seaweeds. Marine Drugs 18 (5):250. doi:10.3390/md18050250.
  • Verhoef, J. J., and T. J. Anchordoquy. 2013. Questioning the use of PEGylation for drug delivery. Drug Delivery and Translational Research 3 (6):499–503. doi:10.1007/s13346-013-0176-5.
  • Victor, S. P., and C. P. Sharma. 2015. Chapter 9 - Anti-inflammatory drug delivery systems using marine products. In Functional Marine Biomaterials, ed. S.-K. Kim, 137–47. Woodhead Publishing, Cambridge, UK.
  • Vijay, N. K. G., and C. Vellapandian. 2023. Ameliorative effects of phlorotannin-rich fraction of Sargassum tenerrimum in high-fat diet and low dose streptozotocin-induced metabolic changes and oxidative stress in diabetic rats. Journal of Herbmed Pharmacology 12 (3):367–79.
  • Vissers, A. M., A. Caligiani, S. Sforza, J. P. Vincken, and H. Gruppen. 2017. Phlorotannin composition of Laminaria digitata. Phytochemical Analysis 28 (6):487–95. doi:10.1002/pca.2697.
  • Wang, T., R. Jonsdottir, and G. Ólafsdóttir. 2009. Total phenolic compounds, radical scavenging and metal chelation of extracts from Icelandic seaweeds. Food Chemistry 116 (1):240–8. doi:10.1016/j.foodchem.2009.02.041.
  • Wei, P., E. J. Cornel, and J. Du. 2021. Ultrasound-responsive polymer-based drug delivery systems. Drug Delivery and Translational Research 11 (4):1323–39. doi:10.1007/s13346-021-00963-0.
  • Wekre, M. E., S. Hellesen Brunvoll, and M. Jordheim. 2022. Advancing quantification methods for polyphenols in brown seaweeds—Applying a selective qNMR method compared with the TPC assay. Phytochemical Analysis 33 (7):1099–110. doi:10.1002/pca.3162.
  • Xie, C., Z. J. Lee, S. Ye, C. J. Barrow, F. R. Dunshea, and H. A. Suleria. 2023. A review on seaweeds and seaweed-derived polysaccharides: Nutrition, chemistry, bioactivities, and applications. Food Reviews International 1–36. doi:10.1080/87559129.2023.2212055.
  • Yadav, D., and H. K. Dewangan. 2021. PEGYLATION: An important approach for novel drug delivery system. Journal of Biomaterials Science. Polymer Edition 32 (2):266–80. doi:10.1080/09205063.2020.1825304.
  • Yang, H., M. Yoon, J. Kim, and S. Cho. 2014. Acute oral toxicity of phlorotannins in beagle dogs. Korean Journal of Fisheries and Aquatic Sciences 47 (4):356–62. doi:10.5657/KFAS.2014.0356.
  • Yao, D., M. Dong, C. Dai, and S. Wu. 2019. Inflammation and inflammatory cytokine contribute to the initiation and development of ulcerative colitis and its associated cancer. Inflammatory Bowel Diseases 25 (10):1595–602. doi:10.1093/ibd/izz149.
  • Yeo, M., W.-K. Jung, and G. Kim. 2012. Fabrication, characterisation and biological activity of phlorotannin-conjugated PCL/β-TCP composite scaffolds for bone tissue regeneration. Journal of Materials Chemistry 22 (8):3568–77. doi:10.1039/c2jm14725d.
  • Yingying, M., L. Xiu-Xia, C. Luyun, and L. Jianrong. 2022. pH-Sensitive ε-polylysine/polyaspartic acid/zein nanofiber membranes for the targeted release of polyphenols. Food & Function 13 (12):6792–801. doi:10.1039/d1fo03051e.
  • Yoshioka, H., M. Ishida, K. Nishi, H. Oda, H. Toyohara, and T. Sugahara. 2014. Studies on anti-allergic activity of Sargassum horneri extract. Journal of Functional Foods 10:154–60. doi:10.1016/j.jff.2014.06.002.
  • Zhang, J., A. Hassane Hamadou, C. Chen, and B. Xu. 2023. Encapsulation of phenolic compounds within food-grade carriers and delivery systems by pH-driven method: A systematic review. Critical Reviews in Food Science and Nutrition 63 (19):4153–74. doi:10.1080/10408398.2021.1998761.
  • Zhang, J., L. Zhang, C. Lai, Y. Liang, L. Gao, K. Kaliaperumal, and Y. Jiang. 2022. Nutraceutical potential of navel orange peel in diabetes management: The chemical profile, antioxidant, α-glucosidase inhibitory and antiglycation effects of its flavonoids. Food Bioscience 49:101943. doi:10.1016/j.fbio.2022.101943.
  • Zhang, S., A. Taehwan Kim, X. Liu, L. Yan, and S. Moo Kim. 2020. Antioxidant and antidiabetic activities of vanadium-binding protein and trifuhalol A. Journal of Food Biochemistry 44 (12):e13540. doi:10.1111/jfbc.13540.
  • Zhao, W., V. Subbiah, C. Xie, Z. Yang, L. Shi, C. Barrow, F. Dunshea, and H. A. Suleria. 2023. Bioaccessibility and bioavailability of phenolic compounds in seaweed. Food Reviews International 39 (8):5729–60. doi:10.1080/87559129.2022.2094404.
  • Znad, H., M. R. Awual, and S. Martini. 2022. The utilization of algae and seaweed biomass for bioremediation of heavy metal-contaminated wastewater. Molecules 27 (4):1275. doi:10.3390/molecules27041275.
  • Zou, L-q., W. Liu, W-l Liu, R-h Liang, T. Li, C-m Liu, Y-l Cao, J. Niu, and Z. Liu. 2014. Characterization and bioavailability of tea polyphenol nanoliposome prepared by combining an ethanol injection method with dynamic high-pressure microfluidization. Journal of Agricultural and Food Chemistry 62 (4):934–41. doi:10.1021/jf402886s.