Unraveling the gut microbiota’s role in Rheumatoid arthritis: dietary pathways to modulation and therapeutic potential

References

• Ahluwalia, B., M. K. Magnusson, and L. Öhman. 2017. Mucosal immune system of the gastrointestinal tract: Maintaining balance between the good and the bad. Scandinavian Journal of Gastroenterology 52 (11):1185–93. doi:10.1080/00365521.2017.1349173.
   PubMed Web of Science ®Google Scholar
• Arpaia, N., C. Campbell, X. Fan, S. Dikiy, J. van der Veeken, P. deRoos, H. Liu, J. R. Cross, K. Pfeffer, P. J. Coffer, et al. 2013. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504 (7480):451–5. doi:10.1038/nature12726.
   PubMed Web of Science ®Google Scholar
• Bach, J. F. 2018. The hygiene hypothesis in autoimmunity: The role of pathogens and commensals. Nature Reviews. Immunology 18 (2):105–20. doi:10.1038/nri.2017.111.
   PubMed Web of Science ®Google Scholar
• Bai, Y., Y. Li, T. Marion, Y. Tong, M. M. Zaiss, Z. Tang, Q. Zhang, Y. Liu, and Y. Luo. 2021. Resistant starch intake alleviates collagen-induced arthritis in mice by modulating gut microbiota and promoting concomitant propionate production. Journal of Autoimmunity 116:102564. doi:10.1016/j.jaut.2020.102564.
   PubMed Web of Science ®Google Scholar
• Ben-Amram, H., T. Bashi, N. Werbner, H. Neuman, M. Fridkin, M. Blank, Y. Shoenfeld, and O. Koren. 2017. Tuftsin-phosphorylcholine maintains normal gut microbiota in collagen induced arthritic mice. Frontiers in Microbiology 8:1222. doi:10.3389/fmicb.2017.01222.
   PubMed Web of Science ®Google Scholar
• Breban, M., J. Tap, A. Leboime, R. Said-Nahal, P. Langella, G. Chiocchia, J.-P. Furet, and H. Sokol. 2017. Faecal microbiota study reveals specific dysbiosis in spondyloarthritis. Annals of the Rheumatic Diseases 76 (9):1614–22. doi:10.1136/annrheumdis-2016-211064.
   PubMed Web of Science ®Google Scholar
• Chen, J., K. Wright, J. M. Davis, P. Jeraldo, E. V. Marietta, J. Murray, H. Nelson, E. L. Matteson, and V. Taneja. 2016. An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis. Genome Medicine 8 (1):43. doi:10.1186/s13073-016-0299-7.
   PubMed Web of Science ®Google Scholar
• Clavel, C., L. Nogueira, L. Laurent, C. Iobagiu, C. Vincent, M. Sebbag, and G. Serre. 2008. Induction of macrophage secretion of tumor necrosis factor α through Fcγ receptor IIa engagement by rheumatoid arthritis–specific autoantibodies to citrullinated proteins complexed with fibrinogen. Arthritis and Rheumatism 58 (3):678–88. doi:10.1002/art.23284.
   PubMed Web of Science ®Google Scholar
• Cong, S., L. Wang, Y. Meng, X. Cai, C. Zhang, Y. Gu, X. Ma, and L. Luo. 2023. Saussurea involucrata oral liquid regulates gut microbiota and serum metabolism during alleviation of collagen-induced arthritis in rats. Phytotherapy Research: PTR 37 (4):1242–59. doi:10.1002/ptr.7681.
   PubMed Web of Science ®Google Scholar
• Cramp, F. 2019. The role of non-pharmacological interventions in the management of rheumatoid-arthritis-related fatigue. Rheumatology 58 (Supplement_5):v22–v28. doi:10.1093/rheumatology/kez310.
   PubMedGoogle Scholar
• Crofford, L. J. 2013. Use of NSAIDs in treating patients with arthritis. Arthritis Research & Therapy 15 (Suppl 3):S2. doi:10.1186/ar4174.
   PubMed Web of Science ®Google Scholar
• Dadoun, S., N. Zeboulon-Ktorza, C. Combescure, M. Elhai, S. Rozenberg, L. Gossec, and B. J. J. B. S. Fautrel. 2013. Mortality in rheumatoid arthritis over the last fifty years: Systematic review and meta-analysis. Joint Bone Spine 80 (1):29–33. doi:10.1016/j.jbspin.2012.02.005.
   PubMed Web of Science ®Google Scholar
• Darrah, E., and F. Andrade. 2018. Rheumatoid arthritis and citrullination. Current Opinion in Rheumatology 30 (1):72–8. doi:10.1097/BOR.0000000000000452.
   PubMed Web of Science ®Google Scholar
• de los Angeles Pineda, M., S. F. Thompson, K. Summers, F. de Leon, J. Pope, and G. Reid. 2011. A randomized, double-blinded, placebo-controlled pilot study of probiotics in active rheumatoid arthritis. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 17 (6):CR347–CR354. doi:10.12659/MSM.881808.
   PubMed Web of Science ®Google Scholar
• Ege, M. J. 2017. The hygiene hypothesis in the age of the microbiome. Annals of the American Thoracic Society 14 (Supplement_5):S348–S353. doi:10.1513/AnnalsATS.201702-139AW.
   PubMedGoogle Scholar
• Fan, Z., R. P. Ross, C. Stanton, B. Hou, J. Zhao, H. Zhang, B. Yang, and W. Chen. 2021. Lactobacillus casei CCFM1074 alleviates collagen-induced arthritis in rats via balancing Treg/Th17 and modulating the metabolites and gut microbiota. Frontiers in Immunology 12:680073. doi:10.1002/eji.200939578.
   PubMed Web of Science ®Google Scholar
• Feng, Y., Y. Yu, Z. Chen, L. Wang, J. Ma, X. Bai, Y. Sun, and D. Wang. 2022. Effects of β-carotin and green tea powder diets on alleviating the symptoms of gouty arthritis and improving gut microbiota in C57BL/6 Mice. Frontiers in Microbiology 13:837182. doi:10.3389/fmicb.2022.837182.
   PubMed Web of Science ®Google Scholar
• Fine, R. L., S. Manfredo Vieira, M. S. Gilmore, and M. A. Kriegel. 2020. Mechanisms and consequences of gut commensal translocation in chronic diseases. Gut Microbes 11 (2):217–30. doi:10.1080/19490976.2019.1629236.
   PubMed Web of Science ®Google Scholar
• Flak, M. B., R. A. Colas, E. Muñoz-Atienza, M. A. Curtis, J. Dalli, and C. Pitzalis. 2019. Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis. JCI Insight 4 (13):125191. doi:10.1172/jci.insight.125191.
   PubMed Web of Science ®Google Scholar
• Fraenkel, L., J. M. Bathon, B. R. England, E. W. St.Clair, T. Arayssi, K. Carandang, K. D. Deane, M. Genovese, K. K. Huston, G. Kerr, et al. 2021. 2021 American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis & Rheumatology 73 (7):1108–23. doi:10.1002/art.41752.
   PubMed Web of Science ®Google Scholar
• Garip, Y., E. Filiz, A. Kiliçarslan, and H. Bodur. 2015. Prevalence of neuropathic pain in rheumatic disorders: Association with disease activity, functional status and quality of life. Archives of Rheumatology 30 (3):231–7. doi:10.5606/ArchRheumatol.2015.5295.
   Web of Science ®Google Scholar
• Geuking, M. B., Y. Köller, S. Rupp, and K. D. McCoy. 2014. The interplay between the gut microbiota and the immune system. Gut Microbes 5 (3):411–8. doi:10.4161/gmic.29330.
   PubMed Web of Science ®Google Scholar
• Guo, Q., Y. Wang, D. Xu, J. Nossent, N. J. Pavlos, and J. Xu. 2018. Rheumatoid arthritis: Pathological mechanisms and modern pharmacologic therapies. Bone Research 6 (1):15. doi:10.1038/s41413-018-0016-9.
   PubMed Web of Science ®Google Scholar
• Harre, U., D. Georgess, H. Bang, A. Bozec, R. Axmann, E. Ossipova, P.-J. Jakobsson, W. Baum, F. Nimmerjahn, E. Szarka, et al. 2012. Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. The Journal of Clinical Investigation 122 (5):1791–802. doi:10.1172/JCI60975.
   PubMed Web of Science ®Google Scholar
• Hatakka, K., J. Martio, M. Korpela, M. Herranen, T. Poussa, T. Laasanen, M. Saxelin, H. Vapaatalo, E. Moilanen, and R. Korpela. 2003. Effects of probiotic therapy on the activity and activation of mild rheumatoid arthritis–a pilot study. Scandinavian Journal of Rheumatology 32 (4):211–5. doi:10.1080/03009740310003695.
   PubMed Web of Science ®Google Scholar
• Hewlett, S., T. Chalder, E. Choy, F. Cramp, B. Davis, E. Dures, C. Nicholls, and J. Kirwan. 2011. Fatigue in rheumatoid arthritis: Time for a conceptual model. Rheumatology 50 (6):1004–6. doi:10.1093/rheumatology/keq282.
   PubMed Web of Science ®Google Scholar
• Holers, V. M., M. K. Demoruelle, K. A. Kuhn, J. H. Buckner, W. H. Robinson, Y. Okamoto, J. M. Norris, and K. D. Deane. 2018. Rheumatoid arthritis and the mucosal origins hypothesis: Protection turns to destruction. Nature Reviews Rheumatology 14 (9):542–57. doi:10.1038/s41584-018-0070-0.
   PubMed Web of Science ®Google Scholar
• Horta-Baas, G., A. Sandoval-Cabrera, and M. d S. Romero-Figueroa. 2021. Modification of gut microbiota in inflammatory arthritis: Highlights and future challenges. Current Rheumatology Reports 23 (8):67. doi:10.1007/s11926-021-01031-9.
   PubMed Web of Science ®Google Scholar
• Jiang, Z.-M., S.-L. Zeng, T.-Q. Huang, Y. Lin, F.-F. Wang, X.-J. Gao, J. Li, P. Li, and E.-H. Liu. 2023. Sinomenine ameliorates rheumatoid arthritis by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation. Science Bulletin 68 (14):1540–55. doi:10.1016/j.scib.2023.06.027.
   PubMed Web of Science ®Google Scholar
• Jianghui, H., N. Jimin, J. Zheng, G. Yanlei, Y. Yong, Y. Cheng, S. Xiongjie, X. Hui, L. Yanju, and L. Hongtao. 2023. Tripterygium hypoglaucum extract ameliorates adjuvant-induced arthritis in mice through the gut microbiota. Chinese Journal of Natural Medicines 21 (10):730–44. doi:10.1016/S1875-5364(23)60466-2.
   PubMed Web of Science ®Google Scholar
• Jiao, Y., L. Wu, N. D. Huntington, and X. Zhang. 2020. Crosstalk between gut microbiota and innate immunity and its implication in autoimmune diseases. Frontiers in Immunology 11:282. doi:10.3389/fimmu.2020.00282.
   PubMed Web of Science ®Google Scholar
• Juarez, M., H. Bang, F. Hammar, U. Reimer, B. Dyke, I. Sahbudin, C. D. Buckley, B. Fisher, A. Filer, and K. Raza. 2016. Identification of novel antiacetylated vimentin antibodies in patients with early inflammatory arthritis. Annals of the Rheumatic Diseases 75 (6):1099–107. doi:10.1136/annrheumdis-2014-206785.
   PubMed Web of Science ®Google Scholar
• Kim, C. H. 2018. Microbiota or short-chain fatty acids: Which regulates diabetes? Cellular & Molecular Immunology 15 (2):88–91. doi:10.1038/cmi.2017.57.
   PubMed Web of Science ®Google Scholar
• Kim, G.-W., G. Gocevski, C.-J. Wu, and X.-J. Yang. 2010. Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery. International Journal of Cell Biology 2010:632739–14. doi:10.1155/2010/632739.
   PubMedGoogle Scholar
• Kishikawa, T., Y. Maeda, T. Nii, D. Motooka, Y. Matsumoto, M. Matsushita, H. Matsuoka, M. Yoshimura, S. Kawada, S. Teshigawara, et al. 2020. Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population. Annals of the Rheumatic Diseases 79 (1):103–11. doi:10.1136/annrheumdis-2019-215743.
   PubMed Web of Science ®Google Scholar
• Köhler, B. M., J. Günther, D. Kaudewitz, and H.-M. J. J. o c m Lorenz. 2019. Current therapeutic options in the treatment of rheumatoid arthritis. Journal of Clinical Medicine 8 (7):938. doi:10.3390/jcm8070938.
   PubMed Web of Science ®Google Scholar
• Lai, W., C. Wang, R. Lai, X. Peng, and J. Luo. 2022. Lycium barbarum polysaccharide modulates gut microbiota to alleviate rheumatoid arthritis in a rat model. NPJ Science of Food 6 (1):34. doi:10.1038/s41538-022-00149-z.
   PubMedGoogle Scholar
• Larsen, J. M. 2017. The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology 151 (4):363–74. doi:10.1111/imm.12760.
   PubMed Web of Science ®Google Scholar
• Li, J., H. Jia, X. Cai, H. Zhong, Q. Feng, S. Sunagawa, M. Arumugam, J. R. Kultima, E. Prifti, T. Nielsen, MetaHIT Consortium., et al. 2014. An integrated catalog of reference genes in the human gut microbiome. Nature Biotechnology 32 (8):834–41. doi:10.1038/nbt.2942.
   PubMed Web of Science ®Google Scholar
• Li, N., X. Li, R. Su, R. Wu, H.-Q. Niu, J. Luo, C. Gao, X. Li, and C. Wang. 2022. Low-dose interleukin-2 altered gut microbiota and ameliorated collagen-induced arthritis. Journal of Inflammation Research 15:1365–79. doi:10.2147/JIR.S344393.
   PubMed Web of Science ®Google Scholar
• Li, Y., M. Dai, L. Wang, and G. Wang. 2021. Polysaccharides and glycosides from Aralia echinocaulis protect rats from arthritis by modulating the gut microbiota composition. Journal of Ethnopharmacology 269:113749. doi:10.1016/j.jep.2020.113749.
   PubMed Web of Science ®Google Scholar
• Liao, Y., B. Xie, H. Zhang, Q. He, L. Guo, M. Subramanieapillai, B. Fan, C. Lu, and R. S. McIntyre. 2019. Efficacy of omega-3 PUFAs in depression: A meta-analysis. Translational Psychiatry 9 (1):190. doi:10.1038/s41398-019-0515-5.
   PubMed Web of Science ®Google Scholar
• Liu, J., F. Peng, H. Cheng, D. Zhang, Y. Zhang, L. Wang, F. Tang, J. Wang, Y. Wan, J. Wu, et al. 2023. Chronic cold environment regulates rheumatoid arthritis through modulation of gut microbiota-derived bile acids. The Science of the Total Environment 903:166837. doi:10.1016/j.scitotenv.2023.166837.
   PubMed Web of Science ®Google Scholar
• Liu, M., S. Li, N. Cao, Q. Wang, Y. Liu, Q. Xu, L. Zhang, C. Sun, X. Xiao, and J. Yao. 2023. Intestinal flora, intestinal metabolism, and intestinal immunity changes in complete Freud’s adjuvant-rheumatoid arthritis C57BL/6 mice. International Immunopharmacology 125 (Pt A):111090. doi:10.1016/j.intimp.2023.111090.
   PubMedGoogle Scholar
• Liu, X., B. Zeng, J. Zhang, W. Li, F. Mou, H. Wang, Q. Zou, B. Zhong, L. Wu, H. Wei, et al. 2016. Role of the gut microbiome in modulating arthritis progression in mice. Scientific Reports 6 (1):30594. doi:10.1038/srep30594.
   PubMedGoogle Scholar
• Liu, X., J. Zhang, Q. Zou, B. Zhong, H. Wang, F. Mou, L. Wu, and Y. Fang. 2016. Lactobacillus salivarius isolated from patients with rheumatoid arthritis suppresses collagen-induced arthritis and increases Treg frequency in mice. Journal of Interferon Cytokine Research 36 (12):706–12. doi:10.1089/jir.2016.0057.
   PubMed Web of Science ®Google Scholar
• Liu, X., Q. Zou, B. Zeng, Y. Fang, and H. Wei. 2013. Analysis of fecal Lactobacillus community structure in patients with early rheumatoid arthritis. Current Microbiology 67 (2):170–6. doi:10.1007/s00284-013-0338-1.
   PubMed Web of Science ®Google Scholar
• Ma, Y., W. Li, S. Niu, X. Zhu, M. Chu, W. Wang, W. Sun, X. Wei, J. Zhang, and Z. Zhang. 2023. BzATP reverses ferroptosis-induced gut microbiota disorders in collagen-induced arthritis mice. International Immunopharmacology 124 (Pt A):110885. doi:10.1016/j.intimp.2023.110885.
   PubMedGoogle Scholar
• Maeda, Y., T. Kurakawa, E. Umemoto, D. Motooka, Y. Ito, K. Gotoh, K. Hirota, M. Matsushita, Y. Furuta, M. Narazaki, et al. 2016. Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis & Rheumatology (Hoboken, N.J.) 68 (11):2646–61. doi:10.1002/art.39783.
   PubMed Web of Science ®Google Scholar
• Malmström, V., A. I. Catrina, and L. Klareskog. 2017. The immunopathogenesis of seropositive rheumatoid arthritis: From triggering to targeting. Nature Reviews. Immunology 17 (1):60–75. doi:10.1038/nri.2016.124.
   PubMed Web of Science ®Google Scholar
• Marita Cross, E. S., D. Hoy, L. Carmona, F. Wolfe, T. Vos, B. Williams, S. Gabriel, M. Lassere, N. Johns, R. Buchbinder, et al. 2014. The global burden of rheumatoid arthritis: Estimates from the global burden of disease 2010 study. Annals of the Rheumatic Diseases 73 (7):1316–22. doi:10.1136/annrheumdis-2013-204627.
   PubMed Web of Science ®Google Scholar
• Moon, J., A. R. Lee, H. Kim, J. Jhun, S.-Y. Lee, J. W. Choi, Y. Jeong, M. S. Park, G. E. Ji, and M.-L. Cho. 2023. Faecalibacterium prausnitzii alleviates inflammatory arthritis and regulates IL-17 production, short chain fatty acids, and the intestinal microbial flora in experimental mouse model for rheumatoid arthritis. Arthritis ResearchTherapy 25 (1):130. doi:10.1186/s13075-023-03118-3.
   Google Scholar
• Nakajima, M., K. Arimatsu, T. Kato, Y. Matsuda, T. Minagawa, N. Takahashi, H. Ohno, and K. Yamazaki. 2015. Oral administration of P. gingivalis induces dysbiosis of gut microbiota and impaired barrier function leading to dissemination of enterobacteria to the liver. PLoS One 10 (7): e0134234. doi:10.1371/journal.pone.0134234.
   PubMed Web of Science ®Google Scholar
• Nemoto, N., Y. Takeda, H. Nara, A. Araki, M. Y. Gazi, Y. Takakubo, Y. Naganuma, M. Takagi, and H. Asao. 2020. Analysis of intestinal immunity and flora in a collagen-induced mouse arthritis model: Differences during arthritis progression. International Immunology 32 (1):49–56. doi:10.1093/intimm/dxz058.
   PubMed Web of Science ®Google Scholar
• Pianta, A., S. L. Arvikar, K. Strle, E. E. Drouin, Q. Wang, C. E. Costello, and A. C. Steere. 2017. Two rheumatoid arthritis–specific autoantigens correlate microbial immunity with autoimmune responses in joints. The Journal of Clinical Investigation 127 (8):2946–56. doi:10.1172/JCI93450.
   PubMed Web of Science ®Google Scholar
• Picchianti-Diamanti, A., C. Panebianco, S. Salemi, M. L. Sorgi, R. Di Rosa, A. Tropea, M. Sgrulletti, G. Salerno, F. Terracciano, R. D’Amelio, et al. 2018. Analysis of gut microbiota in rheumatoid arthritis patients: Disease-related dysbiosis and modifications induced by etanercept. International Journal of Molecular Sciences 19 (10):2938. doi:10.3390/ijms19102938.
   PubMed Web of Science ®Google Scholar
• Radu, A.-F., and S. G. Bungau. 2021. Management of rheumatoid arthritis: An overview. Cells 10 (11):2857. doi:10.3390/cells10112857.
   PubMed Web of Science ®Google Scholar
• Reyes-Castillo, Z., E. Valdés-Miramontes, M. Llamas-Covarrubias, and J. F. J. C. Muñoz-Valle. 2021. Troublesome friends within us: The role of gut microbiota on rheumatoid arthritis etiopathogenesis and its clinical and therapeutic relevance. Clinical and Experimental Medicine 21 (1):1–13. doi:10.1007/s10238-020-00647-y.
   PubMed Web of Science ®Google Scholar
• Round, J. L., and S. K. Mazmanian. 2009. The gut microbiota shapes intestinal immune responses during health and disease. Nature Reviews. Immunology 9 (5):313–23. doi:10.1038/nri2515.
   PubMed Web of Science ®Google Scholar
• Sánchez, B., S. Delgado, A. Blanco-Míguez, A. Lourenço, M. Gueimonde, and A. Margolles. 2017. Probiotics, gut microbiota, and their influence on host health and disease. Molecular Nutrition & Food Research 61 (1):1600240. doi:10.1002/mnfr.201600240.
   Web of Science ®Google Scholar
• Scher, J. U., A. Sczesnak, R. S. Longman, N. Segata, C. Ubeda, C. Bielski, T. Rostron, V. Cerundolo, E. G. Pamer, S. B. Abramson, et al. 2013. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife 2:e01202. doi:10.7554/eLife.01202.
   PubMed Web of Science ®Google Scholar
• Scherer, H. U., T. Häupl, and G. R. Burmester. 2020. The etiology of rheumatoid arthritis. Journal of Autoimmunity 110:102400. doi:10.1016/j.jaut.2019.102400.
   PubMed Web of Science ®Google Scholar
• Simon, G. M., J. Cheng, and J. I. Gordon. 2012. Quantitative assessment of the impact of the gut microbiota on lysine ε-acetylation of host proteins using gnotobiotic mice. Proceedings of the National Academy of Sciences 109 (28):11133–8. doi:10.1073/pnas.1208669109.
   PubMed Web of Science ®Google Scholar
• Smolen, J. S., R. B. M. Landewé, J. W. J. Bijlsma, G. R. Burmester, M. Dougados, A. Kerschbaumer, I. B. McInnes, A. Sepriano, R. F. van Vollenhoven, M. de Wit, et al. 2020. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Annals of the Rheumatic Diseases 79 (6):685–99. doi:10.1136/annrheumdis-2011-70-08.
   PubMed Web of Science ®Google Scholar
• Strachan, D. P. 1989. Hay fever, hygiene, and household size. BMJ (Clinical Research ed.) 299 (6710):1259–60. doi:10.1136/bmj.299.6710.1259.
   PubMed Web of Science ®Google Scholar
• Sun, H., Y. Guo, H. Wang, A. Yin, J. Hu, T. Yuan, S. Zhou, W. Xu, P. Wei, S. Yin, et al. 2023. Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis. Gut 72 (9):1664–77. doi:10.1136/gutjnl-2022-327756.
   PubMed Web of Science ®Google Scholar
• Thaiss, C. A., N. Zmora, M. Levy, and E. Elinav. 2016. The microbiome and innate immunity. Nature 535 (7610):65–74. doi:10.1038/nature18847.
   PubMed Web of Science ®Google Scholar
• Vaghef-Mehrabany, E., B. Alipour, A. Homayouni-Rad, S.-K. Sharif, M. Asghari-Jafarabadi, and S. Zavvari. 2014. Probiotic supplementation improves inflammatory status in patients with rheumatoid arthritis. Nutrition (Burbank, Los Angeles County, Calif.) 30 (4):430–5. doi:10.1016/j.nut.2013.09.007.
   PubMed Web of Science ®Google Scholar
• Vos, T., S. S. Lim, C. Abbafati, K. M. Abbas, M. Abbasi, M. Abbasifard, M. Abbasi-Kangevari, H. Abbastabar, F. Abd-Allah, and A. Abdelalim, GBD 2019 Diseases and Injuries Collaborators. 2020. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. The Lancet (London, England) 396 (10258):1204–22. doi:10.1016/S0140-6736(20)30925-9.
   PubMed Web of Science ®Google Scholar
• Wang, X., D. Liu, D. Li, J. Yan, J. Yang, X. Zhong, Q. Xu, Y. Xu, Y. Xia, Q. Wang, et al. 2023. Combined treatment with glucosamine and chondroitin sulfate improves rheumatoid arthritis in rats by regulating the gut microbiota. Nutrition & Metabolism 20 (1):1–12. doi:10.1186/s12986-023-00735-2.
   PubMed Web of Science ®Google Scholar
• Wang, Y., S. Chen, K. Du, C. Liang, S. Wang, E. Owusu Boadi, J. Li, X. Pang, J. He, and Y.-X. Chang. 2021. Traditional herbal medicine: Therapeutic potential in rheumatoid arthritis. Journal of Ethnopharmacology 279:114368. doi:10.1016/j.jep.2021.114368.
   PubMed Web of Science ®Google Scholar
• Weyand, C. M., and J. J. Goronzy. 2021. The Immunology of Rheumatoid Arthritis. Nature immunology 22 (1):10–8.
   Google Scholar
• Wu, R., Q. Shen, P. Li, and N. Shang. 2022. Sturgeon chondroitin sulfate restores the balance of gut microbiota in colorectal cancer bearing mice. International Journal of Molecular Sciences 23 (7):3723. doi:10.3390/ijms23073723.
   PubMed Web of Science ®Google Scholar
• Xu, H., H. Zhao, D. Fan, M. Liu, J. Cao, Y. Xia, D. Ju, C. Xiao, and Q. Guan. 2020. Interactions between gut microbiota and immunomodulatory cells in rheumatoid arthritis. Mediators of Inflammation 2020:1430605–14. doi:10.1155/2020/1430605.
   PubMed Web of Science ®Google Scholar
• Yanagibashi, T., A. Hosono, A. Oyama, M. Tsuda, S. Hachimura, Y. Takahashi, K. Itoh, K. Hirayama, K. Takahashi, and S. Kaminogawa. 2009. Bacteroides induce higher IgA production than Lactobacillus by increasing activation-induced cytidine deaminase expression in B cells in murine Peyer’s patches. Bioscience, Biotechnology, and Biochemistry 73 (2):372–7. doi:10.1271/bbb.80612.
   PubMed Web of Science ®Google Scholar
• Zaiss, M. M., H.-J. Joyce Wu, D. Mauro, G. Schett, and F. Ciccia. 2021. The gut–joint axis in rheumatoid arthritis. Nature Reviews Rheumatology 17 (4):224–37. doi:10.1038/s41584-021-00585-3.
   PubMed Web of Science ®Google Scholar
• Zamani, B., H. R. Golkar, S. Farshbaf, M. Emadi-Baygi, M. Tajabadi-Ebrahimi, P. Jafari, R. Akhavan, M. Taghizadeh, M. R. Memarzadeh, and Z. Asemi. 2016. Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: A randomized, double-blind, placebo-controlled trial. International Journal of Rheumatic Diseases 19 (9):869–79. doi:10.1111/1756-185X.12888.
   PubMed Web of Science ®Google Scholar
• Zhang, F., A. H. Jonsson, A. Nathan, N. Millard, M. Curtis, Q. Xiao, M. Gutierrez-Arcelus, W. Apruzzese, G. F. Watts, and D. J. N. Weisenfeld. 2023. Deconstruction of Rheumatoid Arthritis Synovium Defines Inflammatory Subtypes. Nature 623 (7987):616–24.
   Google Scholar
• Zhang, X., D. Zhang, H. Jia, Q. Feng, D. Wang, D. Liang, X. Wu, J. Li, L. Tang, Y. Li, et al. 2015. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nature Medicine 21 (8):895–905. doi:10.1038/nm.3914.
   PubMed Web of Science ®Google Scholar
• Zhang, Z., H. Wan, J. Han, X. Sun, R. Yu, B. Liu, C. Lu, J. Zhou, and X. Su. 2022. Ameliorative effect of tuna elastin peptides on AIA mice by regulating the composition of intestinal microorganisms and SCFAs. Journal of Functional Foods 92:105076. doi:10.1016/j.jff.2022.105076.
   Web of Science ®Google Scholar