References
- Alaiz, M., Navarro, J., Girón, J., and Vioque, J. 1992. Amino acid analysis by high- performance liquid chromatography after derivatization with diethyl ethoxymethylenemalonate. J. Chroma. 591: 181–186.
- AOAC, 1995. Official Methods of Analysis of the Association of Official Analytical Chemists (15th ed.) Washington, DC: Author. Pp. 1110–1117.
- Belén, D., Moreno, M., García, D., Medina C., and Sidorovas, A. 2007. Caracterización de un hidrolizado proteíco enzimático obtenido del pez caribe colorado (Pygocentrus cariba HUMBOLDT, 1821). Inerciencia 32(3): 188–194.
- Brown, N., and Vaughan, D. 1998. Angiotensin-converting enzyme inhibitors. Circulation 97:1411–1420.
- Chel, L., Domínguez, M., Martínez, A., Dávila, G., and Betancur, D. 2012. Lima bean (Phaseolus lunatus) protein hydrolysates with ACE inhibitory activity. Food Nutr. Sci. 3:511–521.
- Chen, J. 2003. Overview of sea cucumber farming and sea ranching practices in China. SPC Beche-de-mer Information Bulletin 18: 18–23.
- Cho, M., Unklesbay, N., Hsieh, F., and Clarke, A. 2004. Hydrophobicity of bitter peptides from soy protein hydrolysates. J. Agri. Food Chem. 52(19): 5895–5901.
- Cian, R., Luggren, P., and Drago, S. 2011. Effect of extrusion process on antioxidant and ACE inhibition properties from bovine haemoglobin concentrate hydrolysates incorporated into expanded maize products. Int. J. Food Sci. Nutr. 62(7): 1–7.
- Cinq, C., and Li, E. 2007. Optimizing angiotensin I-converting enzyme inhibitory activity of Pacific hake (Merluccios productus) fillet hydrolysate using response surface methodology and ultrafiltration. J. Agri. Food Chem. 55: 9380–9388.
- Clare, D., and Swaisgood, H. 2000. Bioactive milk peptides: A prospectus. J. Dairy Sci. 83(6):1187–1195.
- Curtis, J., Dennis, D., Waddell, D., MacGillivray, T., and Ewart, F. 2002. Determination of angiotensin-converting enzyme inhibitory peptide Leu-Lys-Pro-Asn-Met (LKPNM) in bonito muscle hydrolysates by LC-MS/MS. J. Agri. Food Chem. 50: 3919–3925.
- Cushman, D., Wang, F., Fung, W., Grover, G., Harvey, C., Scalese, R., Mitch, S., and Deforrest, J. 1989. Comparisons in vitro, ex vivo, and in vivo of the actions of seven structurally diverse inhibitors of angiotensin-converting enzyme (ACE). Br. J. Clin. Pharm. 28: 115–131.
- Dávalos, A., Miguel, M., Bartolomé, B., and López, R. 2004. Antioxity activity of peptides derived from egg white proteins by enzymatic hydrolysis. J. Food Prot. 67(9): 1939–1044.
- Dive, V., Cotton, J., Yiotakis, A., Michaud, A., Vassiliou, S., Jiracek, J., Vazeux, G., Chauvet, M., Cuniasse, P., and Corvol, P. 1999. RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites. Proc. Natl. Acad. Sci. USA 96: 4330–4335.
- Eisenthal, R., and Danson, M. 2002. Enzyme Assays (2nd ed.). Oxford, UK: University Press. Pp. 20–22.
- FAO. 2007. Protein and Amino Acids Requirements in Human Nutrition: Report of a Joint FAO/WHO/UNU Expert Consultation (World Health Organization Technical Report Series 935). Rome, Italy: Author.
- Fischer, M., Kodof, L., Schols, H., Piersman, S., Gruppen, H., and Voragen A. 2001. Enzymatic extractability of soybean meal proteins and carbohydrates: Heat and humidity effects. J. Agri. Food Chem. 49: 4463–4469.
- Fitzgerald, R., and Meisel, H. 2000. Milk protein-derived peptide inhibitors of angiotensin-I- converting enzyme. Br. J. Nutr. 84: 33–37.
- Fitzgerald, R., and Murray, B. 2006. Bioactive peptides and lactic fermentations. J. Dairy Tech. 8: 451–457.
- Forghani, B., Ebrahimpour, A., Bakar, J., Abdul Hamid, A., Hassan, Z., and Saari, N 2012. Enzyme hydrolysates from Stichopus horrens as a new source for angiotensin-converting enzyme inhibitory peptides. Evid. Based Complement. Alternat. Med. 2012: 1–9
- Fu, X., Xue, C., Miao, B., Li, Z., Gao, X., and Yang, W. 2005. Characterization of proteases from the digestive tract of sea cucumber (Stichopus japonicus): High alkaline protease activity. Aquaculture 246(1–4): 321–329.
- Fujita, H., Yokoyama, K., and Yoshikawa, M. 2000. Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. Food Chem. Toxicol. 4: 564–569.
- Hamada, J. 2000. Characterization and functional properties of rice bran proteins modified by commercial exoproteases and endoproteases. J. Food Sci. 65(2): 305–310.
- Hayakari, M., Kondo, Y., and Izumi, H. 1978. A rapid and simple spectrophotometric assay of angiotensin-converting enzyme. Analyt. Biochem. 84: 361–369.
- Izzo, J., and Black, H. 2003. Hypertension Primer—The Essentials of High Blood Pressure: Basic Science, Population Science and Clinical Management. Philadelphia, PA: American Heart Association. Pp. 325–327.
- McCarthy, A., O’Callaghan, Y., and O’Brien, N. 2013. Protein hydrolysates from agricultural crops—Bioactivity and potential for functional food development. Agriculture 3: 112–130.
- Megías, C., Yust, M., Pedroche, J., Lquari, H., Girón, J., Alaiz, M., Millán, F., and Vioque, J. 2004. Purification of an ACE inhibitory peptide after hydrolysis of sunflower (Helianthus annuus L.) protein isolates. J. Agri. Food Chem. 52: 1928–1932.
- Neves, R., De Mira, N., and Marquez, U. 2004. Caracterizacáo de hidrolisados enzimáticos de pescado. Ciénc. Tecnol. Aliment., Campinas 24(1): 101–108.
- Nielsen, P., Petersen, D., and Damdmann, C. 2001. Improved method for determining food protein degree of hydrolysis. J. Food Sci. 66: 642–646.
- Olivera, L., Davalos, A., Grant, G., Valadez, N., Montero, J., Barrera, H., Chim, Y., and Rodriguez, R. 2013. Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats. PloS One 10(4): e79446.
- Pedroche, J., Yust, M., Girón, J., Alaiz, M., Millá, F., and Vioque, J. 2002. Utilization of chickpea protein isolates for production of peptides with angiotensin I-converting enzyme (ACE)-inhibitory activity. J. Sci. Food Agri. 82(9): 960–964.
- Pedroche, J., Yust, M., Girón, J., Vioque, J., Alaiz, M., and Millán, M. 2003. Plant protein hydrolyzates and tailor-made foods. Elec. J. Envir. Agri. Food Chem. 2(1): 233–235.
- Pedroche, J., Yust, M., Megías, C., Lquari, H., Alaiz, M., Girón, J., Millán, F., and Vioque J. 2004. Utilisation of rapeseed protein isolates for production of peptides with angiotensin I-converting enzyme (ACE)-inhibitory activity. Grasas y Aceites 55(4): 354–358.
- Pérez, J., Olivera, L., Gómez, J., and Hernández, B. 2013. Release of multifunctional peptides by gastrointestinal digestion of sea cucumber (Isostichopus badionotus). J. Funct. Foods 5(2): 869–877.
- Plaami, S., Dekker, M., and Jongen, W. 2006. Functional Foods: A Conceptual Model for Assessing Their Safety and Effectiveness. The Hague, The Netherlands: Innovation Network Rural Areas and Agricultural Systems.
- Saito, M., Kunizaki, N., Urano, N., and Kimura, S. 2002. Collagen as the major edible component of sea cucumber. J. Food Sci. 67(4): 1319–1322.
- Schägger, H. and von Jagow, G. 1987. Tricine-sodium dodecil sulfate-poliacrylamide gel electrophoresis for the separation of protein in the range from 1 to 100 kDa. Analyt. Biochem. 166(2): 368–379.
- Stellwagen, E. 1990. Gel filtration. In: Methods in Enzymology (Vol. 182: Guide to Protein Purification). Deutscher, M. (Ed.). Houston, TX: Gulf Professional Publishing. Pp. 317–328.
- Turner, A., and Hooper, N. 2002. The angiotensin-converting enzyme gene family: Genomics and pharmacology. Trends Pharm. Sci. 23: 177–183.
- Tzacos, A., Galanis, A., Spyroulias, G., Cordopatis, P., Manessi, E., and Gerothanassis, I. 2003. Structure-function discrimination of the N- and C-catalytic domains of human angiotensin-converting enzyme: Implications for Cl− activation and peptide hydrolysis mechanisms. J. Prot. Eng. 16(12): 993–1003.
- Wang, W., and González, E. 2005. A new frontier in soy bioactive peptides that may prevent age-related chronic diseases. Compr. Rev. Food Sci. F. 4: 63–78.
- Wroblewska, B., Karamac, M., Amarowicz, R., Szymkiewicz, A., Troszynka, A., and Kubicka, E. 2004. Inmunoreactive properties of peptide fractions of cow whey milk proteins alter enzymatic hidrolysis. Int. J. Food Sci. Tech. 39: 839–850.
- Yamamoto, N. 1997. Antihypertensive peptides derived from food proteins. Biopolymers 43: 129–134.
- Yust, M., Pedroche, J., Girón, J., Alaiz, M., Millán, F., and Vioque, J. 2003. Production of ACE inhibitory peptides by digestion of chickpea legumin with Alcalase®. Food Chem. 81: 363–369.
- Zhao, Y., Li, B., Liu, Z., Dong, S., Zhao, X., and Zeng, M. 2007. Antihypertensive effect and purification of an ACE inhibitory peptide from sea cucumber gelatin hydrolysate. Process Biochem. 42(12): 1586–1591.
- Zhong, Y., Ahmad, M., and Shahidi, F. 2007. Compositional characteristics and antioxidant properties of fresh and processed sea cucumber (Cucumaria frondosa). J. Agri. Food Chem 55: 1118–1192.