Incorporation of ion exchange functionalized-montmorillonite into solid lipid nanoparticles with low irritation enhances drug bioavailability for glaucoma treatment

References

• Agarwal R, Iezhitsa I, Agarwal P, et al. (2016). Liposomes in topical ophthalmic drug delivery: an update. Drug Deliv 23:1–91.
   PubMed Web of Science ®Google Scholar
• Alboofetileh M, Rezaei M, Hosseini H, et al. (2013). Effect of montmorillonite clay and biopolymer concentration on the physical and mechanical properties of alginate nanocomposite films. J Food Eng 117:26–33.
   Web of Science ®Google Scholar
• Angius F, Floris A. (2015). Liposomes and MTT cell viability assay: an incompatible affair. Toxicol in Vitro 29:314–9.
   PubMed Web of Science ®Google Scholar
• Araujo J, et al. (2009). Nanomedicines for ocular NSAIDs: safety on drug delivery. Nanomedicine 5:394–401.
   PubMed Web of Science ®Google Scholar
• Arthur S, Cantor LB. (2011). Update on the role of alpha-agonists in glaucoma management. Exp Eye Res 93:271–83.
   PubMed Web of Science ®Google Scholar
• Baig MS, Ahad A, Aslam M, et al. (2016). Application of Box-Behnken design for preparation of levofloxacin-loaded stearic acid solid lipid nanoparticles for ocular delivery: optimization, in vitro release, ocular tolerance, and antibacterial activity. Int J Biol Macromol 85:258–70.
   PubMed Web of Science ®Google Scholar
• Chatterjee A, Kumar L, Bhowmik BB, et al. (2011). Microparticulated anti-HIV vaginal gel: in vitro-in vivo drug release and vaginal irritation study. Pharm Dev Technol 16:466–73.
   PubMed Web of Science ®Google Scholar
• Chen DW, Foldvari M. (2016). In vitro bioassay model for screening non-viral neurotrophic factor gene delivery systems for glaucoma treatment. Drug Deliv and Transl Res 6:676–85.
   PubMed Web of Science ®Google Scholar
• Chen X, Sullivan DA, Sullivan AG, et al. (2018). Toxicity of cosmetic preservatives on human ocular surface and adnexal cells. Exp Eye Res 170:188–97.
   PubMed Web of Science ®Google Scholar
• Chetoni P, Burgalassi S, Monti D, et al. (2016). Solid lipid nanoparticles as promising tool for intraocular tobramycin delivery: Pharmacokinetic studies on rabbits. Eur J Pharm Biopharm 109:214–23.
   PubMed Web of Science ®Google Scholar
• Chetoni P, Monti D, Tampucci S, et al. (2015). Liposomes as a potential ocular delivery system of distamycin A. Int J Pharm 492:120–6.
   PubMed Web of Science ®Google Scholar
• Cohen LP, Pasquale LR. (2014). Clinical characteristics and current treatment of glaucoma. Cold Spring Harb Perspect Med 4:a017236.
   PubMed Web of Science ®Google Scholar
• Cremers TIFH, Flik G, Hofland C, et al. (2012). Microdialysis evaluation of clozapine and N-desmethylclozapine pharmacokinetics in rat brain. Drug Metab Dispos 40:1909–16.
   PubMed Web of Science ®Google Scholar
• Doktorovova S, Shegokar R, Martins-Lopes P, et al. (2012). Modified Rose Bengal assay for surface hydrophobicity evaluation of cationic solid lipid nanoparticles (cSLN). Eur J Pharm Sci 45:606–12.
   PubMed Web of Science ®Google Scholar
• Erkin EF, Çelik P, Kayıkçıoğlu Ö, et al. (2006). Effects of latanoprost and betaxolol on cardiovascular and respiratory status of newly diagnosed glaucoma patients. Ophthalmologica 220:332–7.
   PubMed Web of Science ®Google Scholar
• Fernandes AV, Pydi CR, Verma R, et al. (2020). Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers. Braz. J. Pharm. Sci 56:e18069
   Web of Science ®Google Scholar
• Georgiev GA, Eftimov P, and Yokoi N, et al. (2019). Contribution of Mucins towards the physical properties of the tear film: a modern update. Int J Mol Sci 20:6132.
   PubMed Web of Science ®Google Scholar
• Gipson IK, Hori Y, Argüeso P, et al. (2004). Character of ocular surface mucins and their alteration in dry eye disease. The Ocular Surface 2:131–48.
   PubMedGoogle Scholar
• Hao J, Fang X, Zhou Y, et al. (2011). Development and optimization of solid lipid nanoparticle formulation for ophthalmic delivery of chloramphenicol using a Box-Behnken design. Int J Nanomedicine 6:683–92.
   PubMed Web of Science ®Google Scholar
• Hori Y. (2018). Secreted mucins on the ocular surface. Invest Ophthalmol Vis Sci 59:DES151–DES156.
   PubMed Web of Science ®Google Scholar
• Hou D, Gui R, Hu S, et al. (2015). Preparation and characterization of novel drug-inserted-montmorillonite chitosan carriers for ocular drug delivery. ANP 04:70–84.
   Google Scholar
• Hou D, Hu S, Huang Y, et al. (2016). Preparation and in vitro study of lipid nanoparticles encapsulating drug loaded montmorillonite for ocular delivery. Appl Clay Sci 119:277–83.
   Web of Science ®Google Scholar
• Hou D, Xie C, Huang K, et al. (2003). The production and characteristics of solid lipid nanoparticles (SLNs). Biomaterials 24:1781–5.
   PubMed Web of Science ®Google Scholar
• Huang W, Zhang N, Hua H, et al. (2016). Preparation, pharmacokinetics and pharmacodynamics of ophthalmic thermosensitive in situ hydrogel of betaxolol hydrochloride. Biomed Pharmacother 83:107–13.
   PubMed Web of Science ®Google Scholar
• Huang Y, Tao Q, Hou D, et al. (2017). A novel ion-exchange carrier based upon liposome-encapsulated montmorillonite for ophthalmic delivery of betaxolol hydrochloride. IJN Volume 12:1731–45.
   Web of Science ®Google Scholar
• Imperiale JC, Acosta GB, Sosnik A, et al. (2018). Polymer-based carriers for ophthalmic drug delivery. J Control Release 285:106–41.
   PubMed Web of Science ®Google Scholar
• Jain AK, Jain A, Garg NK, et al. (2014). Adapalene loaded solid lipid nanoparticles gel: an effective approach for acne treatment. Colloids Surf B Biointerfaces 121:222–9.
   PubMed Web of Science ®Google Scholar
• Joseph RR, Venkatraman SS. (2017). Drug delivery to the eye: what benefits do nanocarriers offer? Nanomedicine 12:683–702.
   PubMed Web of Science ®Google Scholar
• Kalinin S, Valtari A, Ruponen M, et al. (2019). Highly hydrophilic 1,3-oxazol-5-yl benzenesulfonamide inhibitors of carbonic anhydrase II for reduction of glaucoma-related intraocular pressure. Bioorg Med Chem 27:115086.
   PubMed Web of Science ®Google Scholar
• Kamata K. (2003). Effect of a selective inducible nitric oxide synthase inhibitor on intraocular nitric oxide production in endotoxin-induced uveitis rabbits: in vivo intraocular microdialysis study. Pharmacol Res 47:485–91.
   PubMed Web of Science ®Google Scholar
• Kumar L, Reddy MS, Shirodkar RK, et al. (2013). Preparation and characterisation of fluconazole vaginal films for the treatment of vaginal candidiasis. Indian J Pharm Sci 75:585–90.
   PubMed Web of Science ®Google Scholar
• Lee M-K, Lim S-J, Kim C-K, et al. (2007). Preparation, characterization and in vitro cytotoxicity of paclitaxel-loaded sterically stabilized solid lipid nanoparticles. Biomaterials 28:2137–46.
   PubMed Web of Science ®Google Scholar
• Leonardi A, Bucolo C, Drago F, et al. (2015). Cationic solid lipid nanoparticles enhance ocular hypotensive effect of melatonin in rabbit. Int J Pharm 478:180–6.
   PubMed Web of Science ®Google Scholar
• Lin J, Wu H, Wang Y, et al. (2014). Preparation and ocular pharmacokinetics of hyaluronan acid-modified mucoadhesive liposomes. Drug Deliv 23:1–51.
   PubMed Web of Science ®Google Scholar
• Lin R-Y, Chen B-S, Chen G-L, et al. (2009). Preparation of porous PMMA/Na+–montmorillonite cation-exchange membranes for cationic dye adsorption. J Membr Sci 326:117–29.
   Web of Science ®Google Scholar
• Louis KS, Siegel AC. (2011). Cell viability analysis using trypan blue: manual and automated methods. Methods Mol Biol 740:7–12.
   PubMedGoogle Scholar
• M A Fathalla Z, Vangala A, Longman M, et al. (2017). Poloxamer-based thermoresponsive ketorolac tromethamine in situ gel preparations: design, characterisation, toxicity and transcorneal permeation studies. Eur J Pharm Biopharm 114:119–34.
   PubMed Web of Science ®Google Scholar
• Mou J, Liu Z, Liu J, et al. (2019). Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation. Drug Deliv 26:179–87.
   PubMed Web of Science ®Google Scholar
• Nascimento D. F d, Silva AC, Mansur CRE, et al. (2012). Characterization and evaluation of poly(epsilon-caprolactone) nanoparticles containing 2-ethylhexyl-p-methoxycinnamate, octocrylene, and benzophenone-3 in anti-solar preparations. j Nanosci Nanotechnol 12:7155–66.
   PubMed Web of Science ®Google Scholar
• Onyebuchi C, Kavaz D. (2019). Chitosan and N, N, N-Trimethyl chitosan nanoparticle encapsulation of ocimum gratissimum essential oil: optimised synthesis. IJN 14:7707–27.
   Web of Science ®Google Scholar
• Park CG, Kim YK, Kim MJ, et al. (2015). Mucoadhesive microparticles with a nanostructured surface for enhanced bioavailability of glaucoma drug. J Control Release 220:180–8.
   PubMed Web of Science ®Google Scholar
• Read ML, Navascues-Cornago M, Keirb N, et al. (2019). The impact of contact lens wear on ocular surface mucins using a novel clinical fluorescence imaging system. Cont Lens Anterior Eye S1367-0484:30224–3.
   Google Scholar
• Santos B. R d, Bacalhau FB, Pereira T. d S, et al. (2015). Chitosan-Montmorillonite microspheres: A sustainable fertilizer delivery system. Carbohydr Polym 127:340–6.
   PubMed Web of Science ®Google Scholar
• Seyfoddin A, Shaw J, Al-Kassas R, et al. (2010). Solid lipid nanoparticles for ocular drug delivery. Drug Deliv 17:467–89.
   PubMed Web of Science ®Google Scholar
• Shen J, Lu GW, Hughes P, et al. (2018). Targeted ocular drug delivery with pharmacokinetic/pharmacodynamic considerations. Pharm Res 35:217.
   PubMed Web of Science ®Google Scholar
• Tang W, Zhang F, Liu K, et al. (2019). Efficacy and safety of prostaglandin analogues in primary open-angle glaucoma or ocular hypertension patients: a meta-analysis. Medicine 98:e16597.
   PubMed Web of Science ®Google Scholar
• Tian S, Li J, Tao Q, et al. (2018). Controlled drug delivery for glaucoma therapy using montmorillonite/Eudragit microspheres as an ion-exchange carrier. IJN 13:415–28.
   Web of Science ®Google Scholar
• Vinardell MP, García L. (2000). The quantitive chlorioallantoic membrane test using trypan blue stain to predict the eye irritancy of liquid scintillation cocktails. Toxicology in Vitro: An International Journal Published in Association with BIBRA 14:551–5.
   PubMed Web of Science ®Google Scholar
• Wang X, Du Y, Luo J, et al. (2008). Biopolymer/montmorillonite nanocomposite: preparation, drug-controlled release property and cytotoxicity. Nanotechnology 19:065707.
   PubMed Web of Science ®Google Scholar
• Weinreb RN, Khaw PT. (2004). Primary open-angle glaucoma. The Lancet 363:1711–20.
   PubMed Web of Science ®Google Scholar
• Xu K, et al. (2017). Impact of combination glaucoma therapies on beta-blocker exposure. J Glaucoma 26:e107–e109.
   PubMed Web of Science ®Google Scholar
• Yavuz B, Kompella UB. (2017). Ocular drug delivery. Handb Exp Pharmacol 242:57–93.
   PubMedGoogle Scholar
• Yellepeddi VK, Sheshala R, McMillan H, et al. (2015). Punctal plug: a medical device to treat dry eye syndrome and for sustained drug delivery to the eye. Drug Discov Today 20:884–9.
   PubMed Web of Science ®Google Scholar