Engineered biomaterial strategies for controlling growth factors in tissue engineering

References

• Ahsan SM, Thomas M, Reddy KK, et al. (2018). Chitosan as biomaterial in drug delivery and tissue engineering. Int J Biol Macromol 110:97–109.
   PubMed Web of Science ®Google Scholar
• Aloe L, Rocco ML, Balzamino BO, Micera A. (2016). Nerve growth factor: role in growth, differentiation and controlling cancer cell development. J Exp Clin Cancer Res 35:116.
   PubMed Web of Science ®Google Scholar
• Amsden B. (2015). Novel biodegradable polymers for local growth factor delivery. Eur J Pharm Biopharm 97:318–28.
   PubMed Web of Science ®Google Scholar
• Arisaka Y, Yui N. (2019). Engineering molecularly mobile polyrotaxane surfaces with heparin-binding EGF-like growth factors for improving hepatocyte functions. J Biomed Mater Res A 107:1080–5.
   PubMed Web of Science ®Google Scholar
• Azizian S, Hadjizadeh A, Niknejad H. (2018). Chitosan-gelatin porous scaffold incorporated with Chitosan nanoparticles for growth factor delivery in tissue engineering. Carbohydr Polym 202:315–22.
   PubMed Web of Science ®Google Scholar
• Benedetti L, Cortivo R, Berti T, et al. (1993). Biocompatibility and biodegradation of different hyaluronan derivatives (Hyaff) implanted in rats. Biomaterials 14:1154–60.
   PubMed Web of Science ®Google Scholar
• Barclay TG, Day CM, Petrovsky N, Garg S. (2019). Review of polysaccharide particle-based functional drug delivery. Carbohydr Polym 221:94–112.
   PubMed Web of Science ®Google Scholar
• Beneke CE, Viljoen AM, Hamman JH. (2009). Polymeric plant-derived excipients in drug delivery. Molecules 14:2602–20.
   PubMed Web of Science ®Google Scholar
• Bhaskar U, Sterner E, Hickey AM, et al. (2012). Engineering of routes to heparin and related polysaccharides. Appl Microbiol Biotechnol 93:1–16.
   PubMed Web of Science ®Google Scholar
• Brasil FH, Ferrer V, Navone NM, et al. (2016). Heparan sulfate modifying enzymes deliver cancer, stromal and macrophage-produced heparin-binding growth factors in the prostate cancer microenvironment. Can Res, 76:5102.
   Web of Science ®Google Scholar
• Caballero Aguilar LM, Silva SM, Moulton SE. (2019). Growth factor delivery: defining the next generation platforms for tissue engineering. J Control Release 306:40–58.
   PubMed Web of Science ®Google Scholar
• Catizone A, Ricci G, Del Bravo J, Galdieri M. (2006). Hepatocyte growth factor modulates in vitro survival and proliferation of germ cells during postnatal testis development. J Endocrinol 189:137–46.
   PubMed Web of Science ®Google Scholar
• Chen Z, Cheng L, He Y, Wei X. (2018). Extraction, characterization, utilization as wound dressing and drug delivery of Bletilla striata polysaccharide: a review. Int J Biol Macromol 120:2076–85.
   PubMed Web of Science ®Google Scholar
• Chen S, Huang H, Huang G. (2019). Extraction, derivatization and antioxidant activity of cucumber polysaccharide. Int J Biol Macromol 140:1047–53.
   PubMed Web of Science ®Google Scholar
• Choi DH, Kang SN, Kim SM, et al. (2016). Growth factors-loaded stents modified with hyaluronic acid and heparin for induction of rapid and tight re-endothelialization. Colloids Surf B Biointerfaces 141:602–10.
   PubMed Web of Science ®Google Scholar
• Choi DH, Park CH, Kim IH, et al. (2010). Fabrication of core-shell microcapsules using PLGA and alginate for dual growth factor delivery system. J Control Release 147:193–201.
   PubMed Web of Science ®Google Scholar
• Chu X, Chen C, Chen C, et al. (2019). Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast growth factors. Front Med 14:262–272 .
   PubMed Web of Science ®Google Scholar
• Cipitria A, Salmeron-Sanchez M. (2017). Mechanotransduction and growth factor signalling to engineer cellular microenvironments. Adv Healthcare Mater 6:1700052.
   Web of Science ®Google Scholar
• Dao DT, Anez-Bustillos L, Adam RM, et al. (2018). Heparin-binding epidermal growth factor-like growth factor as a critical mediator of tissue repair and regeneration. Am J Pathol 188:2446–56.
   PubMed Web of Science ®Google Scholar
• Davydova N, Harris NC, Roufail S, et al. (2016). Differential receptor binding and regulatory mechanisms for the lymphangiogenic growth factors vascular endothelial growth factor (VEGF)-C and -D. J Biol Chem 291:27265–78.
   PubMed Web of Science ®Google Scholar
• DeAngelis PL. (2012). Glycosaminoglycan polysaccharide biosynthesis and production: today and tomorrow. Appl Microbiol Biotechnol 94:295–305.
   PubMed Web of Science ®Google Scholar
• Debele TA, Mekuria SL, Tsai H-C. (2016). Polysaccharide based nanogels in the drug delivery system: application as the carrier of pharmaceutical agents. Mater Sci Eng C Mater Biol Appl 68:964–81.
   PubMed Web of Science ®Google Scholar
• Degirolamo C, Sabbà C, Moschetta A. (2016). Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. Nat Rev Drug Discov 15:51–69.
   PubMed Web of Science ®Google Scholar
• Dinoro J, Maher M, Talebian S, et al. (2019). Sulfated polysaccharide-based scaffolds for orthopaedic tissue engineering. Biomaterials 214:119214
   PubMed Web of Science ®Google Scholar
• Duncan HF, Kobayashi Y, Shimizu E. (2018). Growth factors and cell homing in dental tissue regeneration. Curr Oral Health Rep 5:276–85.
   PubMedGoogle Scholar
• Erdogan B, Webb DJ. (2017). Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis. Biochem Soc Trans 45:229–36.
   PubMed Web of Science ®Google Scholar
• Evans BC, Fletcher RB, Kilchrist KV, et al. (2019). An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles. Nat Commun 10:1–19.,
   PubMed Web of Science ®Google Scholar
• Feng Y, Li Q, Wu D, et al. (2017). A macrophage-activating, injectable hydrogel to sequester endogenous growth factors for in situ angiogenesis. Biomaterials 134:128–42.,
   PubMed Web of Science ®Google Scholar
• Figueroa V, Rodríguez MS, Lanari C, Lamb CA. (2019). Nuclear action of FGF members in endocrine-related tissues and cancer: interplay with steroid receptor pathways. Steroids 152:108492
   PubMed Web of Science ®Google Scholar
• Gallego-Muñoz P, Ibares-Frías L, Valsero-Blanco MC, et al. (2017). Effects of TGFβ1, PDGF-BB, and bFGF, on human corneal fibroblasts proliferation and differentiation during stromal repair. Cytokine 96:94–101.,
   PubMed Web of Science ®Google Scholar
• Goh M, Hwang Y, Tae G. (2016). Epidermal growth factor loaded heparin-based hydrogel sheet for skin wound healing. Carbohydr Polym 147:251–60.
   PubMed Web of Science ®Google Scholar
• Gohil S, Padmanabhan A, Deschamps J, Nair L. (2017). Chitosan-based scaffolds for growth factor delivery. In: Chitosan Based Biomaterials Volume 2. Woodhead Publishing: Elsevier, 175–207.
   Google Scholar
• Gu F, Amsden B, Neufeld R. (2004). Sustained delivery of vascular endothelial growth factor with alginate beads. J Control Release 96:463–72.
   PubMed Web of Science ®Google Scholar
• Guo JL, Kim YS, Mikos AG. (2019). Biomacromolecules for tissue engineering: emerging biomimetic strategies. Biomacromolecules 20:2904–12.
   PubMed Web of Science ®Google Scholar
• Hachim D, Whittaker TE, Kim H, Stevens MM. (2019). Glycosaminoglycan-based biomaterials for growth factor and cytokine delivery: making the right choices. J Control Release 313:131–47.
   PubMed Web of Science ®Google Scholar
• Hellberg C, Östman A. Heldin C-H. (2010). PDGF and vessel maturation, Angiogenesis inhibition. Berlin, Heidelberg: Springer, 103–114.
   Google Scholar
• Hendrikse SI, Spaans S, Meijer E, Dankers PY. (2018). Supramolecular platform stabilizing growth factors. Biomacromolecules 19:2610–7.
   PubMed Web of Science ®Google Scholar
• Hettiaratchi MH, Chou C, Servies N, et al. (2017). Competitive protein binding influences heparin-based modulation of spatial growth factor delivery for bone regeneration. Tissue Eng Part A 23:683–95.
   PubMed Web of Science ®Google Scholar
• Highley CB, Prestwich GD, Burdick JA. (2016). Recent advances in hyaluronic acid hydrogels for biomedical applications. Curr Opin Biotechnol 40:35–40.
   PubMed Web of Science ®Google Scholar
• Hinz B. (2015). The extracellular matrix and transforming growth factor-β1: tale of a strained relationship. Matrix Biol 47:54–65.
   PubMed Web of Science ®Google Scholar
• Ishihara J, Ishihara A, Fukunaga K, et al. (2018). Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing. Nat Commun 9:1–14.
   PubMed Web of Science ®Google Scholar
• Islam S, Bhuiyan MR, Islam M. (2017). Chitin and chitosan: structure, properties and applications in biomedical engineering. J Polym Environ 25:854–66.
   Web of Science ®Google Scholar
• Jeon O, Powell C, Solorio LD, et al. (2011). Affinity-based growth factor delivery using biodegradable, photocrosslinked heparin-alginate hydrogels. J Control Release 154:258–66.
   PubMed Web of Science ®Google Scholar
• Jha SK, Rauniyar K, Karpanen T, et al. (2017). Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1. Sci Rep 7:1–13.
   PubMed Web of Science ®Google Scholar
• Jia J, Ye T, Cui P, et al. (2016). AP-1 transcription factor mediates VEGF-induced endothelial cell migration and proliferation. Microvasc Res 105:103–8.
   PubMed Web of Science ®Google Scholar
• Jiao R, Liu Y, Gao H, et al. (2016). The anti-oxidant and antitumor properties of plant polysaccharides. Am J Chin Med 44:463–88.
   PubMed Web of Science ®Google Scholar
• Kalaf EAG, Flores R, Bledsoe JG, Sell SA. (2016). Characterization of slow-gelling alginate hydrogels for intervertebral disc tissue-engineering applications. Mater Sci Eng C Mater Biol Appl 63:198–210.
   PubMed Web of Science ®Google Scholar
• Kaminski GA, Sierakowski MR, Pontarolo R, et al. (2016). Layer-by-layer polysaccharide-coated liposomes for sustained delivery of epidermal growth factor. Carbohydr Polym 140:129–35.
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Mizuta M, Hiwatashi N, et al. (2017). Drug delivery system of basic fibroblast growth factor using gelatin hydrogel for restoration of acute vocal fold scar. Auris Nasus Larynx 44:86–92.
   PubMed Web of Science ®Google Scholar
• Kumar A, Rao KM, Han SS. (2018). Application of xanthan gum as polysaccharide in tissue engineering: a review. Carbohydr Polym 180:128–44.
   PubMed Web of Science ®Google Scholar
• Le Dour C, Wu W, Béréziat V, et al. (2017). Extracellular matrix remodeling and transforming growth factor-β signaling abnormalities induced by lamin A/C variants that cause lipodystrophy. J Lipid Res 58:151–63.
   PubMed Web of Science ®Google Scholar
• Li Q, Guo G, Meng F, et al. (2016). A naturally derived, growth factor-binding polysaccharide for therapeutic angiogenesis. ACS Macro Lett 5:617–21.
   PubMed Web of Science ®Google Scholar
• Li Q, Niu Y, Diao H, et al. (2017). In situ sequestration of endogenous PDGF-BB with an ECM-mimetic sponge for accelerated wound healing. Biomaterials 148:54–68.
   PubMed Web of Science ®Google Scholar
• Li Q, Niu Y, Xing P, Wang C. (2018). Bioactive polysaccharides from natural resources including Chinese medicinal herbs on tissue repair. Chin Med 13:7.
   PubMed Web of Science ®Google Scholar
• Liu M, Zheng H, Chen J, et al. (2016). Chitosan-chitin nanocrystal composite scaffolds for tissue engineering. Carbohydr Polym 152:832–40.
   PubMed Web of Science ®Google Scholar
• Li G, Xiao Q, Zhang L, et al. (2017). Nerve growth factor loaded heparin/chitosan scaffolds for accelerating peripheral nerve regeneration. Carbohydr Polym 171:39–49.
   PubMed Web of Science ®Google Scholar
• Li W, Yi X, Liu X, et al. (2016). Hyaluronic acid ion-pairing nanoparticles for targeted tumor therapy. J Control Release 225:170–82.
   PubMed Web of Science ®Google Scholar
• Lynam JG, Kumar N, Wong MJ. (2017). Deep eutectic solvents' ability to solubilize lignin, cellulose, and hemicellulose; thermal stability; and density. Bioresour Technol 238:684–9.
   PubMed Web of Science ®Google Scholar
• Mancarella C, Calzolari L, Ferrari S, et al. (2016). Insulin-like growth factor 2 (IGF-2) mRNA binding protein 3 predicts poor prognosis and promotes cell proliferation in Ewing sarcoma. Clin Res, 76(14):3201.
   Google Scholar
• Mangla B, Joshi SK, Khanna K, et al. (2017). Hyaluronic acid: the ingenious molecule. Biopharm J 1:64–70.
   Google Scholar
• Marchioli G, Luca AD, de Koning E, et al. (2016). Hybrid polycaprolactone/alginate scaffolds functionalized with VEGF to promote de novo vessel formation for the transplantation of islets of Langerhans. Adv Healthc Mater 5:1606–16.
   PubMed Web of Science ®Google Scholar
• Mercer SE, Odelberg SJ, Simon H-G. (2013). A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration. Dev Biol 382:457–69.
   PubMed Web of Science ®Google Scholar
• Mhanna R, Becher J, Schnabelrauch M, et al. (2017). Sulfated alginate as a mimic of sulfated glycosaminoglycans: binding of growth factors and effect on stem cell behavior. Adv Biosys 1:1700043.
   Web of Science ®Google Scholar
• Miandare HK, Mirghaed AT, Hosseini M, et al. (2017). Dietary Immunogen((R)) modulated digestive enzyme activity and immune gene expression in Litopenaeus vannamei post larvae. Fish Shellfish Immunol 70:621–7.
   PubMed Web of Science ®Google Scholar
• Miao T, Wang J, Zeng Y, et al. (2018). Polysaccharide-based controlled release systems for therapeutics delivery and tissue engineering: from bench to bedside. Adv Sci 5:1700513.
   Web of Science ®Google Scholar
• Millette E, Rauch BH, Kenagy RD, et al. (2006). Platelet-derived growth factor-BB transactivates the fibroblast growth factor receptor to induce proliferation in human smooth muscle cells. Trends Cardiovasc Med 16:25–8.
   PubMed Web of Science ®Google Scholar
• Mohammadi S, Ramakrishna S, Laurent S, et al. (2019). Fabrication of nanofibrous PVA/alginate-sulfate substrates for growth factor delivery. J Biomed Mater Res A 107:403–13.
   PubMed Web of Science ®Google Scholar
• Necas J, Bartosikova L, Brauner P, Kolar J. (2008). Hyaluronic acid (hyaluronan): a review. Vet Med 53:397–411.
   Web of Science ®Google Scholar
• Nicoletti F, Mazzon E, Fagone P, et al. (2019). Prevention of clinical and histological signs of MOG-induced experimental allergic encephalomyelitis by prolonged treatment with recombinant human EGF. J Neuroimmunol 332:224–32.
   PubMed Web of Science ®Google Scholar
• Nie T, Baldwin A, Yamaguchi N, Kiick KL. (2007). Production of heparin-functionalized hydrogels for the development of responsive and controlled growth factor delivery systems. J Control Release 122:287–96.
   PubMed Web of Science ®Google Scholar
• Niu Y, Li Q, Ding Y, et al. (2019). Engineered delivery strategies for enhanced control of growth factor activities in wound healing. Adv Drug Deliv Rev 146:190–208.
   PubMed Web of Science ®Google Scholar
• Oh J-S, Lee E-J. (2019). Engineered dressing of hybrid chitosan-silica for effective delivery of keratin growth factor and acceleration of wound healing. Mater Sci Eng C Mater Biol Appl 103:109815.
   PubMed Web of Science ®Google Scholar
• Onodera Y, Teramura T, Takehara T, Fukuda K. (2019). Transforming growth factor β-activated kinase 1 regulates mesenchymal stem cell proliferation through stabilization of Yap1/Taz proteins. Stem Cells 37:1595–605.
   PubMed Web of Science ®Google Scholar
• Pangon A, Saesoo S, Saengkrit N, et al. (2016). Hydroxyapatite-hybridized chitosan/chitin whisker bionanocomposite fibers for bone tissue engineering applications. Carbohydr Polym 144:419–27.
   PubMed Web of Science ®Google Scholar
• Pearman N, Moxon S, Carnachan SM, et al. (2019). Investigating potential wound healing properties of polysaccharides extracted from Grewia mollis Juss. and Hoheria populnea A. Cunn.(Malvaceae). Bioact Carbohydr Diet Fibre 20:100201.
   Google Scholar
• Perez RA, El-Fiqi A, Park JH, et al. (2014). Therapeutic bioactive microcarriers: co-delivery of growth factors and stem cells for bone tissue engineering. Acta Biomater 10:520–30.
   PubMed Web of Science ®Google Scholar
• Qian Y, Han Q, Chen W, et al. (2017). Platelet-rich plasma derived growth factors contribute to stem cell differentiation in musculoskeletal regeneration. Front Chem 5:89.
   PubMed Web of Science ®Google Scholar
• Rajam M, Pulavendran S, Rose C, Mandal A. (2011). Chitosan nanoparticles as a dual growth factor delivery system for tissue engineering applications. Int J Pharm 410:145–52.
   PubMed Web of Science ®Google Scholar
• Rao SS, Rekha P, Anil S, et al. (2019). Natural polysaccharides for growth factors delivery. In: Natural polysaccharides in drug delivery and biomedical applications. Academic Press: Elsevier, 495–512.
   Google Scholar
• Reakasame S, Boccaccini AR. (2018). Oxidized alginate-based hydrogels for tissue engineering applications: a review. Biomacromolecules 19:3–21.
   PubMed Web of Science ®Google Scholar
• Roskoski R. Jr, (2017). Vascular endothelial growth factor (VEGF) and VEGF receptor inhibitors in the treatment of renal cell carcinomas. Pharmacol Res 120:116–32.
   PubMed Web of Science ®Google Scholar
• Saito N, Takaoka K. (2003). New synthetic biodegradable polymers as BMP carriers for bone tissue engineering. Biomaterials 24:2287–93.
   PubMed Web of Science ®Google Scholar
• Singh G, Manohar M, Arya SK, et al. (2017). Potential biomedical applications of chitosan–and chitosan-based nanomaterials. Chitosan Deriv Compos Appl 14:385–408.
   Google Scholar
• Shelke NB, James R, Laurencin CT, Kumbar SG. (2014). Polysaccharide biomaterials for drug delivery and regenerative engineering. Polym Adv Technol 25:448–60.
   Web of Science ®Google Scholar
• Smirnova NV, Kolbe KA, Dresvyanina EN, et al. (2019). Effect of chitin nanofibrils on biocompatibility and bioactivity of the chitosan-based composite film matrix intended for tissue engineering. Materials 12:1874.
   PubMed Web of Science ®Google Scholar
• Su Z, Ma H, Wu Z, et al. (2014). Enhancement of skin wound healing with decellularized scaffolds loaded with hyaluronic acid and epidermal growth factor. Mater Sci Eng C Mater Biol Appl 44:440–8.
   PubMed Web of Science ®Google Scholar
• Sun S, Yau A, Chen Y. (2019). Biomedical applications and biomaterial delivery strategies of growth factors. Biomater Transl Med 11:257–68.
   Google Scholar
• Surmacz E. (2003). Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor. Oncogene 22:6589–97.
   PubMed Web of Science ®Google Scholar
• Tam RY, Cooke MJ, Shoichet MSJJoMC. (2012). A covalently modified hydrogel blend of hyaluronan–methyl cellulose with peptides and growth factors influences neural stem/progenitor cell fate. J Mater Chem 22:19402–11.
   Web of Science ®Google Scholar
• Tan H, Chu CR, Payne KA, Marra KG. (2009). Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering. Biomaterials 30:2499–506.
   PubMed Web of Science ®Google Scholar
• Tang D-W, Yu S-H, Ho Y-C, et al. (2010). Heparinized chitosan/poly(γ-glutamic acid) nanoparticles for multi-functional delivery of fibroblast growth factor and heparin. Biomaterials 31:9320–32.
   PubMed Web of Science ®Google Scholar
• Tchobanian A, Van Oosterwyck H, Fardim P. (2019). Polysaccharides for tissue engineering: current landscape and future prospects. Carbohydr Polym 205:601–25.
   PubMed Web of Science ®Google Scholar
• Thönes S, Rother S, Wippold T, et al. (2019). Hyaluronan/collagen hydrogels containing sulfated hyaluronan improve wound healing by sustained release of heparin-binding EGF-like growth factor. Acta Biomater 86:135–47.
   PubMed Web of Science ®Google Scholar
• Tiwari S, Patil R, Bahadur P. (2018). Polysaccharide based scaffolds for soft tissue engineering applications. Polymers 11:1.
   PubMed Web of Science ®Google Scholar
• Uebersax L, Merkle HP, Meinel L. (2009). Biopolymer-based growth factor delivery for tissue repair: from natural concepts to engineered systems. Tissue Eng Part B Rev 15:263–89.
   PubMed Web of Science ®Google Scholar
• van Rensburg AJ, Davies NH, Oosthuysen A, et al. (2017). Improved vascularization of porous scaffolds through growth factor delivery from heparinized polyethylene glycol hydrogels. Acta Biomater 49:89–100.
   PubMed Web of Science ®Google Scholar
• Vanderwerff BR, Church KJ, Kawas LH, Harding JW. (2019). Comparative characterization of the HGF/Met and MSP/Ron systems in primary pancreatic adenocarcinoma. Cytokine 123:154762.
   PubMed Web of Science ®Google Scholar
• Vandghanooni S, Eskandani M. (2019). Electrically conductive biomaterials based on natural polysaccharides: challenges and applications in tissue engineering. Int J Biol Macromol 141:636–62.
   PubMed Web of Science ®Google Scholar
• Venkatesan J, Anil S, Kim S-K, Shim MS. (2017). Chitosan as a vehicle for growth factor delivery: various preparations and their applications in bone tissue regeneration. Int J Biol Macromol 104:1383–97.
   PubMed Web of Science ®Google Scholar
• Venkatesan J, Kim S-K, Wong TW. (2015). Chitosan and its application as tissue engineering scaffolds. In Nanotechnology applications for tissue engineering. William Andrew Publishing: Elsevier, 133–47.
   Google Scholar
• Wang X, Ding J, Feng Y, et al. (2017). Targeting of growth factors in the treatment of hepatocellular carcinoma: the potentials of polysaccharides. Oncol Lett 13:1509–17.
   PubMed Web of Science ®Google Scholar
• Wang B, Lv X, Chen S, et al. (2018). Use of heparinized bacterial cellulose based scaffold for improving angiogenesis in tissue regeneration. Carbohydr Polym 181:948–56.
   PubMed Web of Science ®Google Scholar
• Wang K, Nune K, Misra R. (2016). The functional response of alginate-gelatin-nanocrystalline cellulose injectable hydrogels toward delivery of cells and bioactive molecules. Acta Biomater 36:143–51.
   PubMed Web of Science ®Google Scholar
• Wang Z, Wang Z, Lu WW, et al. (2017). Novel biomaterial strategies for controlled growth factor delivery for biomedical applications. NPG Asia Mater 9:e435–e435.
   Web of Science ®Google Scholar
• Wickens JM, Alsaab HO, Kesharwani P, et al. (2017). Recent advances in hyaluronic acid-decorated nanocarriers for targeted cancer therapy. Drug Discov Today 22:665–80.
   PubMed Web of Science ®Google Scholar
• Xu Y, Ding H, Luo C, et al. (2018). Effect of lignin, cellulose and hemicellulose on calcium looping behavior of CaO-based sorbents derived from extrusion-spherization method. Chem Eng J. 334:2520–2529.
   Web of Science ®Google Scholar
• Yan HJ, Casalini T, Hulsart-Billström G, et al. (2018). Synthetic design of growth factor sequestering extracellular matrix mimetic hydrogel for promoting in vivo bone formation. Biomaterials 161:190–202.
   PubMed Web of Science ®Google Scholar
• Yan J, Miao Y, Tan H, et al. (2016). Injectable alginate/hydroxyapatite gel scaffold combined with gelatin microspheres for drug delivery and bone tissue engineering. Mater Sci Eng C Mater Biol Appl 63:274–84.
   PubMed Web of Science ®Google Scholar
• Yilgor P, Tuzlakoglu K, Reis RL, et al. (2009). Incorporation of a sequential BMP-2/BMP-7 delivery system into chitosan-based scaffolds for bone tissue engineering. Biomaterials 30:3551–9.
   PubMed Web of Science ®Google Scholar
• Yin M, Zhang Y, Li H. (2019). Advances in research on immunoregulation of macrophages by plant polysaccharides. Front. Immunol 10:145.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Sun T, Jiang C. (2018). Biomacromolecules as carriers in drug delivery and tissue engineering. Acta Pharmaceutica Sinica B 8:34–50.
   PubMed Web of Science ®Google Scholar
• Zhang ZD, Xu YQ, Chen F, et al. (2019). Sustained delivery of vascular endothelial growth factor using a dextran/poly(lactic-co-glycolic acid)-combined microsphere system for therapeutic neovascularization. Heart Vessels 34:167–76.
   PubMed Web of Science ®Google Scholar
• Zheng Y, Wu J, Shan W, et al. (2018). Multifunctional nanoparticles enable efficient oral delivery of biomacromolecules via improving payload stability and regulating the transcytosis pathway. ACS Appl Mater Interfaces 10:34039–49.
   PubMed Web of Science ®Google Scholar
• Zhou J, Zhang B, Liu X, et al. (2016). Facile method to prepare silk fibroin/hyaluronic acid films for vascular endothelial growth factor release. Carbohydr Polym 143:301–9.
   PubMed Web of Science ®Google Scholar
• Zubillaga V, Alonso-Varona A, Fernandes S, et al. (2020). Adipose-derived mesenchymal stem cell chondrospheroids cultured in hypoxia and a 3D porous chitosan/chitin nanocrystal scaffold as a platform for cartilage tissue engineering. IJMS 21:1004.
   Web of Science ®Google Scholar