Design and optimization of cranberry extract loaded bile salt augmented liposomes for targeting of MCP-1/STAT3/VEGF signaling pathway in DMN-intoxicated liver in rats

References

• Abd-Elsalam WH, El-Helaly SN, Ahmed MA, Al-Mahallawi AM. (2018). Preparation of novel phospholipid-based sonocomplexes for improved intestinal permeability of rosuvastatin: in vitro characterization, dynamic simulation, Caco-2 cell line permeation and in vivo assessment studies. Int J Pharm 548:375–84.
   PubMed Web of Science ®Google Scholar
• Abd El-Halim SM, Abdelbary GA, Amin MM, et al. (2020). Stabilized oral nanostructured lipid carriers of Adefovir Dipivoxil as a potential liver targeting: Estimation of liver function panel and uptake following intravenous injection of radioiodinated indicator. Daru 28:517–32.
   PubMed Web of Science ®Google Scholar
• Abd El-Halim SM, Mamdouh MA, Eid SM, et al. (2021). The potential synergistic activity of zolmitriptan combined in new self-nanoemulsifying drug delivery systems: ATR-FTIR real-time fast dissolution monitoring and pharmacodynamic assessment. Int J Nanomedicine 16:6395–412.
   PubMed Web of Science ®Google Scholar
• Aboud HM, Ali AA, El-Menshawe SF, Elbary AA. (2016). Nanotransfersomes of carvedilol for intranasal delivery: formulation, characterization and in vivo evaluation. Drug Deliv 23:2471–81.
   PubMed Web of Science ®Google Scholar
• Aguilar-Cazares D, Chavez-Dominguez R, Carlos-Reyes A, et al. (2019). Contribution of angiogenesis to inflammation and cancer. Front Oncol 9:1399–10.
   PubMed Web of Science ®Google Scholar
• Ahmad A, Afroz N, Gupta UD, Ahmad R. (2014). Vitamin B12 supplement alleviates N′-nitrosodimethylamine-induced hepatic fibrosis in rats. Pharm Biol 52:516–23.
   Web of Science ®Google Scholar
• Albash R, Abdelbary AA, Refai H, El-Nabarawi MA. (2019a). Use of transethosomes for enhancing the transdermal delivery of olmesartan medoxomil: in vitro, ex vivo, and in vivo evaluation. Int J Nanomedicine 14:1953–68.
   PubMed Web of Science ®Google Scholar
• Albash R, El-Nabarawi MA, Refai H, Abdelbary AA. (2019b). Tailoring of PEGylated bilosomes for promoting the transdermal delivery of olmesartan medoxomil: in-vitro characterization, ex-vivo permeation and in-vivo assessment. Int J Nanomedicine 14:6555–74.
   PubMed Web of Science ®Google Scholar
• Anderson N, Borlak J. (2008). Mechanisms of hepatotoxicity. In: Sahu SC, ed. Hepatotoxicity: from genomics to in vitro and in vivo models. England: John Wiley & Sons, Ltd, 371–390.
   Google Scholar
• Aziz DE, Abdelbary AA, Elassasy AI. (2019). Investigating superiority of novel bilosomes over niosomes in the transdermal delivery of diacerein: in vitro characterization, ex vivo permeation and in vivo skin deposition study. J Liposome Res 29:73–85.
   PubMed Web of Science ®Google Scholar
• Bataller R, Brenner DA. (2005). Liver fibrosis. J Clin Invest 115:209–18.
   PubMed Web of Science ®Google Scholar
• Bergmeyer H, Scheibe P, Wahlefeld A. (1978). Optimization of methods for aspartate aminotransferase and alanine aminotransferase. Clin Chem 24:58–73.
   PubMed Web of Science ®Google Scholar
• Blumberg JB, Camesano TA, Cassidy A, et al. (2013). Cranberries and their bioactive constituents in human health. Adv Nutr 4:618–32.
   PubMed Web of Science ®Google Scholar
• Bowers GN, Jr, McComb RB. (1966). A continuous spectrophotometric method for measuring the activity of serum alkaline phosphatase. Clin Chem 12:70–89.
   PubMed Web of Science ®Google Scholar
• Bujak T, Zagórska-Dziok M, Ziemlewska A, et al. (2021). Antioxidant and Cytoprotective Properties of Plant Extract from Dry Flowers as Functional Dyes for Cosmetic Products. Molecules 26:2809.
   PubMed Web of Science ®Google Scholar
• Bujor O-C, Ginies C, Popa VI, Dufour C. (2018). Phenolic compounds and antioxidant activity of lingonberry (Vaccinium vitis-idaea L.) leaf, stem and fruit at different harvest periods. Food Chem 252:356–65.
   PubMed Web of Science ®Google Scholar
• Caldas APS, Coelho OGL, Bressan J. (2018). Cranberry antioxidant power on oxidative stress, inflammation and mitochondrial damage. Int J Food Prop 21:582–92.
   Web of Science ®Google Scholar
• Călinoiu LF, Fărcaş A, Socaci S, et al. (2019). Innovative sources. In: Galanakis CM, ed. Nutraceuticals and natural product pharmaceuticals, 1st ed. London: Academic Press; Elsevier, 235–265.
   Google Scholar
• Chen M, Huang H, Zhou P, et al. (2019). Oral phosphatidylcholine improves intestinal barrier function in drug-induced liver injury in rats. Gastroenterol Res Pract 2019:1–6.
   Web of Science ®Google Scholar
• El Kayal M, Nasr M, Mortada N, Elkheshen S. (2020). Optimization of the colloidal properties of different vesicular systems aiming to encapsulate (-)-epigallocatechin-3-gallate. FARMACIA 68:97–110.
   Web of Science ®Google Scholar
• Elnaggar YS. (2015). Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine. Int J Nanomedicine 10:3955–71.
   PubMed Web of Science ®Google Scholar
• Fan L, Chen Q, Mairiyangu Y, et al. (2021). Stable vesicle self-assembled from phospholipid and mannosylerythritol lipid and its application in encapsulating anthocyanins. Food Chem 344:128649–10.
   PubMed Web of Science ®Google Scholar
• Freag MS, Elnaggar YS, Abdallah OY. (2013). Lyophilized phytosomal nanocarriers as platforms for enhanced diosmin delivery: optimization and ex vivo permeation. Int J Nanomed 8:2385–97.
   PubMed Web of Science ®Google Scholar
• Hao Y-M, Li K. (2011). Entrapment and release difference resulting from hydrogen bonding interactions in niosome. Int J Pharm 403:245–53.
   PubMed Web of Science ®Google Scholar
• Hathout RM, Mansour S, Mortada ND, Guinedi AS. (2007). Liposomes as an ocular delivery system for acetazolamide: in vitro and in vivo studies. AAPS PharmSciTech 8:1–E12.
   PubMed Web of Science ®Google Scholar
• He H, Lu Y, Qi J, et al. (2019). Adapting liposomes for oral drug delivery. Acta Pharm Sin B 9:36–48.
   PubMed Web of Science ®Google Scholar
• Hong S-W, Jung KH, Lee H-S, et al. (2011). Suppression by fucoidan of liver fibrogenesis via the TGF-β/Smad pathway in protecting against oxidative stress. Biosci Biotechnol Biochem 75:833–40.
   PubMed Web of Science ®Google Scholar
• Hu S, Niu M, Hu F, et al. (2013). Integrity and stability of oral liposomes containing bile salts studied in simulated and ex vivo gastrointestinal media. Int J Pharm 441:693–700.
   PubMed Web of Science ®Google Scholar
• Ishida Y, Kondo T, Takayasu T, et al. (2004). The essential involvement of cross-talk between IFN-gamma and TGF-beta in the skin wound-healing process. J Immunol 172:1848–55.
   PubMed Web of Science ®Google Scholar
• Jaeschke H. (2000). Reactive oxygen and mechanisms of inflammatory liver injury. J Gastroenterol Hepatol 15:718–24.
   PubMed Web of Science ®Google Scholar
• Khan MI, Madni A, Ahmad S, et al. (2015). Formulation design and characterization of a non-ionic surfactant based vesicular system for the sustained delivery of a new chondroprotective agent. Braz J Pharm Sci 51:607–15.
   Web of Science ®Google Scholar
• Latief U, Ahmad R. (2018). Herbal remedies for liver fibrosis: A review on the mode of action of fifty herbs. J Tradit Complement Med 8:352–60.
   PubMedGoogle Scholar
• Lee C, Bak J, Yoon S, Moon J-O. (2021). Protective effect of Oligonol on Dimethylnitrosamine-induced liver fibrosis in rats via the JNK/NF-κB and PI3K/Akt/Nrf2 signaling pathways. Antioxidants 10:366–14.
   Web of Science ®Google Scholar
• Lee H-T, Xue J, Chou P-C, et al. (2015). Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells. Oncotarget 6:10016–29.
   PubMedGoogle Scholar
• Lee MF, Tsai ML, Sun PP, et al. (2013). Phyto-power dietary supplement potently inhibits Dimethylnitrosamine-induced liver fibrosis in rats. Food Funct 4:470–5.
   PubMed Web of Science ®Google Scholar
• Lin X, Zhang S, Huang Q, et al. (2012). Protective effect of Fufang-Liu-Yue-Qing, a traditional Chinese herbal formula, on CCl4 induced liver fibrosis in rats. J Ethnopharmacol 142:548–56.
   PubMed Web of Science ®Google Scholar
• Liu RH. (2013). Health-promoting components of fruits and vegetables in the diet. Adv Nutr 4:384S–92S.
   PubMed Web of Science ®Google Scholar
• Mosallam S, Ragaie MH, Moftah NH, et al. (2021a). Use of novasomes as a vesicular carrier for improving the topical delivery of terconazole: In vitro characterization, in vivo assessment and exploratory clinical experimentation. Int J Nanomedicine 16:119–32.
   PubMed Web of Science ®Google Scholar
• Mosallam S, Sheta NM, Elshafeey AH, Abdelbary AA. (2021b). Fabrication of highly deformable bilosomes for enhancing the topical delivery of terconazole: In vitro characterization, microbiological evaluation, and in vivo skin deposition study. Am Assoc Pharmac Sci 22:1–12.
   Google Scholar
• Nandhini S, Ilango K. (2021). Development and characterization of a nano-drug delivery system containing vasaka phospholipid complex to improve bioavailability using quality by design approach. Res Pharm Sci 16:103–17.
   PubMed Web of Science ®Google Scholar
• Naugler WE, Sakurai T, Kim S, et al. (2007). Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317:121–4.
   PubMed Web of Science ®Google Scholar
• Niu M, Lu Y, Hovgaard L, et al. (2012). Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: the effect of cholate type, particle size and administered dose. Eur J Pharm Biopharm 81:265–72.
   PubMed Web of Science ®Google Scholar
• Niu M, Lu Y, Hovgaard L, Wu W. (2011). Liposomes containing glycocholate as potential oral insulin delivery systems: preparation, in vitro characterization, and improved protection against enzymatic degradation. Int J Nanomedicine 6:1155–66.
   PubMed Web of Science ®Google Scholar
• Ogata H, Takeya M, Yoshimura T, et al. (1997). The role of monocyte chemoattractant protein‐1 (MCP‐1) in the pathogenesis of collagen‐induced arthritis in rats. J Pathol 182:106–14.
   PubMed Web of Science ®Google Scholar
• Park EJ, Lee JH, Yu G-Y, et al. (2010). Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140:197–208.
   PubMed Web of Science ®Google Scholar
• Rajendar M, Saraswathi B. (2014). Preparation and optimization of diclofenac encapsulation liposomes using lipid hydration technique. World J Pharm Res 3:755–68.
   Google Scholar
• Rasheed DM, Emad AM, Ali SF, et al. (2021). UPLC-PDA-ESI/MS metabolic profiling of dill shoots bioactive fraction; evidence of its antioxidant and hepatoprotective effects in vitro and in vivo. J. Food Biochem 45:1–16.
   Web of Science ®Google Scholar
• Russo GL, Spagnuolo C, Russo M, et al. (2020). Mechanisms of aging and potential role of selected polyphenols in extending healthspan. Biochem Pharmacol 173:Article No.:113719.
   PubMed Web of Science ®Google Scholar
• Saganuwan SA. (2011). A modified arithmetical method of Reed and Muench for determination of a relatively ideal median lethal dose (LD50). Afr J Pharm Pharmacol 5:1543–6.
   Google Scholar
• Saifi Z, Rizwanullah M, Mir SR, Amin S. (2020). Bilosomes nanocarriers for improved oral bioavailability of acyclovir: A complete characterization through in vitro, ex-vivo and in vivo assessment. J Drug Delivery Sci Technol 57:Article No.:101634.
   Web of Science ®Google Scholar
• Sallie R, Tredger JM, Williams R. (1991). Drugs and the liver part 1: Testing liver function. Biopharm Drug Dispos 12:251–9.
   PubMed Web of Science ®Google Scholar
• Sharma G, Beg S, Thanki K, et al. (2015). Systematic development of novel cationic self-nanoemulsifying drug delivery systems of candesartan cilexetil with enhanced biopharmaceutical performance. RSC Adv 5:71500–13.
   Web of Science ®Google Scholar
• Soliman SM, Abdelmalak NS, El-Gazayerly ON, Abdelaziz N. (2016). Novel non-ionic surfactant proniosomes for transdermal delivery of lacidipine: optimization using 2(3) factorial design and in vivo evaluation in rabbits. Drug Deliv 23:1608–22.
   PubMed Web of Science ®Google Scholar
• Song L, Hanlon DW, Chang L, et al. (2011). Single molecule measurements of tumor necrosis factor α and interleukin-6 in the plasma of patients with Crohn's disease. J Immunol Methods 372:177–86.
   PubMed Web of Science ®Google Scholar
• Subongkot T, Pamornpathomkul B, Rojanarata T, et al. (2014). Investigation of the mechanism of enhanced skin penetration by ultradeformable liposomes. Int J Nanomedicine 9:3539–50.
   PubMed Web of Science ®Google Scholar
• Tilg H, Diehl AM. (2000). Cytokines in alcoholic and nonalcoholic steatohepatitis. N Engl J Med 343:1467–76.
   PubMed Web of Science ®Google Scholar
• Trautwein C, Friedman SL, Schuppan D, Pinzani M. (2015). Hepatic fibrosis: concept to treatment. J Hepatol 62:S15–S24.
   PubMed Web of Science ®Google Scholar
• Vitorino C, Carvalho FA, Almeida AJ, et al. (2011). The size of solid lipid nanoparticles: an interpretation from experimental design. Colloids Surf B Biointerfaces 84:117–30.
   PubMed Web of Science ®Google Scholar
• Waghule T, Rapalli VK, Singhvi G, et al. (2021). Design of temozolomide-loaded proliposomes and lipid crystal nanoparticles with industrial feasible approaches: comparative assessment of drug loading, entrapment efficiency, and stability at plasma pH. J Liposome Res 31:158–68.
   PubMed Web of Science ®Google Scholar
• Wang X, Ding G, Liu B, Wang Q. (2020). Flavonoids and antioxidant activity of rare and endangered fern: Isoetes sinensis. Plos One 15:e0232185–12.
   PubMed Web of Science ®Google Scholar
• Whittaker S, Marais R, Zhu A. (2010). The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 29:4989–5005.
   PubMed Web of Science ®Google Scholar
• Xiang Y, Pang BY, Zhang Y, et al. (2017). Effect of Yi Guan Jian decoction on differentiation of bone marrow mesenchymalstem cells into hepatocyte-like cells in dimethylnitrosamine-induced liver cirrhosis in mice. Mol Med Rep 15:613–26.
   PubMed Web of Science ®Google Scholar
• Yoshioka T, Kawada K, Shimada T, Mori M. (1979). Lipid peroxidation in maternal and cord blood and protective mechanism against activated-oxygen toxicity in the blood. Am J Obstet Gynecol 135:372–6.
   PubMed Web of Science ®Google Scholar