References
- Aalinkeel R, Kutscher HL, Singh A, et al. (2018). Neuroprotective effects of a biodegradable poly(lactic-co-glycolic acid)-ginsenoside Rg3 nanoformulation: a potential nanotherapy for Alzheimer’s disease? J Drug Target 26:1492–93.
- Ali W, Ikram M, Park HY, et al. (2020). Oral administration of alpha linoleic acid rescues Aβ-induced glia-mediated neuroinflammation and cognitive dysfunction in C57BL/6N mice. Cells 9:667.
- Allen BD, Syage AR, Maroso M, et al. (2020). Mitigation of helium irradiation-induced brain injury by microglia depletion. J Neuroinflammation 17:1–18.
- Amani H, Habibey R, Shokri F, et al. (2019). Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling. Sci Rep 9:1–15.
- Amin FU, Hoshiar AK, Do TD, et al. (2017). Osmotin-loaded magnetic nanoparticles with electromagnetic guidance for the treatment of Alzheimer’s disease. Nanoscale 9:10619–32.
- Amini P, Nodooshan SJ, Ashrafizadeh M, et al. (2021). Resveratrol induces apoptosis and attenuates proliferation of MCF-7 cells in combination with radiation and hyperthermia. Curr Mol Med 21:142–50.
- Arevalo-Rodriguez I, Smailagic N, Roqué-Figuls M, et al. (2021). Mini‐Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev 7:CD010783.
- Avramović N, Mandić B, Savić-Radojević A, et al. (2020). Polymeric nanocarriers of drug delivery systems in cancer therapy. Pharmaceutics 12:298.
- Ballesteros-Zebadúa P, Chavarria A, Angel Celis M, et al. (2012). Radiation-induced neuroinflammation and radiation somnolence syndrome. CNS Neurol Disord Drug Targets 11:937–49.
- Belka C, Jendrossek V, Pruschy M, et al. (2004). Apoptosis-modulating agents in combination with radiotherapy-current status and outlook. Int J Radiat Oncol Biol Phys 58:542–54.
- Bhatt PC, Srivastava P, Pandey P, et al. (2016). Nose to brain delivery of astaxanthin-loaded solid lipid nanoparticles: fabrication, radio labeling, optimization and biological studies. RSC Adv 6:10001–10.
- Biber K, Neumann H, Inoue K, et al. (2007). Neuronal ‘On’ and ‘Off’ signals control microglia. Trends Neurosci 30:596–602.
- Bicker J, Fortuna A, Alves G, Falcão A. (2020). Nose-to-brain delivery of natural compounds for the treatment of central nervous system disorders. Curr Pharm Des 26:594–619.
- Brown PD, Pugh S, Laack NN, et al. (2013). Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial. Neuro Oncol 15:1429–37.
- Brown WR, Blair RM, Moody DM, et al. (2007). Capillary loss precedes the cognitive impairment induced by fractionated whole-brain irradiation: a potential rat model of vascular dementia. J Neurol Sci 257:67–71.
- Brown WR, Thore CR, Moody DM, et al. (2005). Vascular damage after fractionated whole-brain irradiation in rats. Radiat Res 164:662–8.
- Bruinsmann FA, Richter Vaz G, de Cristo Soares Alves A, et al. (2019). Nasal drug delivery of anticancer drugs for the treatment of glioblastoma: preclinical and clinical trials. Molecules 24:4312.
- Bulloch K, Miller MM, Gal-Toth J, et al. (2008). CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain. J Comp Neurol 508:687–710.
- Byeon JC, Ahn JB, Jang WS, et al. (2019). Recent formulation approaches to oral delivery of herbal medicines. J Pharm Investig 49:17–26.
- Calzoni E, Cesaretti A, Polchi A, et al. (2019). Biocompatible polymer nanoparticles for drug delivery applications in cancer and neurodegenerative disorder therapies. JFB 10:4.
- Camponogara C, Brum ES, Pegoraro NS, et al. (2021). Diosmetin, a novel transient receptor potential vanilloid 1 antagonist, alleviates the UVB radiation-induced skin inflammation in mice. Inflammopharmacol 29:879–895.
- Caritá AC, Fonseca-Santos B, Shultz JD, et al. (2020). Vitamin C: one compound, several uses. Advances for delivery, efficiency and stability. Nanomedicine 24:102117.
- Chambrelant I, Eber J, Antoni D, et al. (2021). Proton therapy and gliomas: a systematic review. Radiation 1:218–33.
- Chan Y-l, Roebuck DJ, Yuen M-P, et al. (2001). Long-term cerebral metabolite changes on proton magnetic resonance spectroscopy in patients cured of acute lymphoblastic leukemia with previous intrathecal methotrexate and cranial irradiation prophylaxis. Int J Radiat Oncol Biol Phys. 50:759–63.
- Chatterjee J, Langhnoja J, Pillai PP, Mustak MS. (2019). Neuroprotective effect of quercetin against radiation-induced endoplasmic reticulum stress in neurons. J Biochem Mol Toxicol 33:e22242.
- Chiang CS, Hong JH, Stalder A, et al. (1997). Delayed molecular responses to brain irradiation. Int J Radiat Biol 72:45–53.
- Chivero ET, Thangaraj A, Tripathi A, et al. (2021). NLRP3 inflammasome blockade reduces cocaine-induced microglial activation and neuroinflammation. Mol Neurobiol 58:2215–30.
- Choi JM, Rotimi OO, O’Carroll SJ, Nicholson LFB. (2016). IL-6 stimulates a concentration-dependent increase in MCP-1 in immortalised human brain endothelial cells. F1000Res 5:270.
- Chong V, Khoo J, Chan L, Rumpel H. (2002). Neurological changes following radiation therapy for head and neck tumours. Eur J Radiol 44:120–9.
- Collins-Underwood JR, Zhao W, Sharpe JG, Robbins ME. (2008). NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells. Free Radic Biol Med 45:929–38.
- Conner KR, Forbes ME, Lee WH, et al. (2011). AT1 receptor antagonism does not influence early radiation-induced changes in microglial activation or neurogenesis in the normal rat brain. Radiat Res 176:71–83.
- Connor JR, Menzies SL. (1995). Cellular management of iron in the brain. J Neurol Sci 134:33–44.
- Constanzo J, Midavaine É, Fouquet J, et al. (2020). Brain irradiation leads to persistent neuroinflammation and long-term neurocognitive dysfunction in a region-specific manner. Prog Neuropsychopharmacol Biol Psychiatry 102:109954.
- Dang Y, An C, Li Y, et al. (2019). Neutrophil-mediated and low density lipoprotein receptor-mediated dual-targeting nanoformulation enhances brain accumulation of scutellarin and exerts neuroprotective effects against ischemic stroke. RSC Adv 9:1299–318.
- Deng Z, Huang H, Wu X, et al. (2017). Distinct expression of various angiogenesis factors in mice brain after whole-brain irradiation by X-ray. Neurochem Res 42:625–33.
- Deng Z, Sui G, Rosa PM, Zhao W. (2012). Radiation-induced c-Jun activation depends on MEK1-ERK1/2 signaling pathway in microglial cells. PLoS One 7:e36739.
- Dewey WC, Ling CC, Meyn RE. (1995). Radiation-induced apoptosis: relevance to radiotherapy. Int J Radiat Oncol Biol Phys 33:781–96.
- Dietrich J, Monje M, Wefel J, Meyers C. (2008). Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy. Oncologist 13:1285–95.
- Ding Y, Wang Y, Chen X. (2013). Effect of Ginkgo flavonoid on acute radiation-induced hippocampal injury in rats. Jiangsu Med J 39:2379–82.
- Duan Y, Fan X, Liu Q, et al. (2011). Clinical observation on Tanshinone IIA in radiation induced senile brain injury. Modern Oncol 19:674–5.
- Edelstein K, Richard NM, Bernstein LJ. (2017). Neurocognitive impact of cranial radiation in adults with cancer: an update of recent findings. Curr Opin Support Palliat Care 11:32–7.
- El-Missiry MA, Othman AI, El-Sawy MR, Lebede MF. (2018). Neuroprotective effect of epigallocatechin-3-gallate (EGCG) on radiation-induced damage and apoptosis in the rat hippocampus. Int J Radiat Biol 94:798–808.
- Elnaggar YS, Etman SM, Abdelmonsif DA, Abdallah OY. (2015). Intranasal piperine-loaded chitosan nanoparticles as brain-targeted therapy in Alzheimer’s disease: optimization, biological efficacy, and potential toxicity. J Pharm Sci 104:3544–56.
- Engelhardt B, Ransohoff RM. (2005). The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol 26:485–95.
- Fauquette W, Amourette C, Dehouck M-P, Diserbo M. (2012). Radiation-induced blood-brain barrier damages: an in vitro study. Brain Res 1433:114–26.
- Flores-Castro M, Sebastian-Barajas G. (2021). Radiotherapy in brain tumors. In: Principles of neuro-oncology. New York: Springer, 313–334.
- Franco-Pérez J, Montes S, Sánchez-Hernández J, Ballesteros-Zebadúa P. (2020). Whole-brain irradiation differentially modifies neurotransmitters levels and receptors in the hypothalamus and the prefrontal cortex. Radiat Oncol 15:1–13.
- Frank MG, Adhikary S, Sobesky JL, et al. (2016). The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine. Brain Behav Immun 51:99–108.
- Fukuda A, Fukuda H, Jönsson M, et al. (2005). Progenitor cell injury after irradiation to the developing brain can be modulated by mild hypothermia or hyperthermia. J Neurochem 94:1604–19.
- Fukunaga H. (2021). Stem cell migration: a possible mechanism for the tissue-sparing effect of spatially fractionated radiation. Radiat Res 196:680–685
- Gaber M, Sabek O, Fukatsu K, et al. (2003). Differences in ICAM-1 and TNF-alpha expression between large single fraction and fractionated irradiation in mouse brain. Int J Radiat Biol 79:359–66.
- Gan L, Wang Z, Zhang H, et al. (2012). Protective effects of hydroxy safflower yellow A on radiation-induced brain injury induced by carbon ion beam irradiation. Nuclear Techn 35:624–9.
- Goodarzi AA, Jeggo PA. (2013). The repair and signaling responses to DNA double-strand breaks. Adv Genet 82:1–45.
- Gorbunov NV, Kiang JG. (2021). Brain damage and patterns of neurovascular disorder after ionizing irradiation. Complications in radiotherapy and radiation combined injury. Radiat Res 196:1–16.
- Greene-Schloesser D, Robbins ME. (2012). Radiation-induced cognitive impairment-from bench to bedside. Neuro-oncology 14:iv37–iv44.
- Guo YR, Liu ZW, Peng S, et al. (2019). The neuroprotective effect of amitriptyline on radiation-induced impairment of hippocampal neurogenesis. Dose Response 17:1559325819895912.
- Han VX, Patel S, Jones HF, Dale RC. (2021). Maternal immune activation and neuroinflammation in human neurodevelopmental disorders. Nat Rev Neurol 17:564–16.
- Hidaka K, Fukushima H, Hosaka S, et al. (2021). Cognitive functions of pediatric brain tumor survivors treated with proton beam therapy: a case series. J Pediatr Hematol Oncol 43:e1205–e1209.
- Ho Q-A, Stea B. (2022). Innovations in radiotherapy and advances in immunotherapy for the treatment of brain metastases. Clin Exp Metastasis 39:225–6.
- Hong J, Lu H, Meng X, et al. (2002). Stability, cellular uptake, biotransformation, and efflux of tea polyphenol (−)-epigallocatechin-3-gallate in HT-29 human colon adenocarcinoma cells. Cancer Res 62:7241–6.
- Hong J-H, Chiang C-S, Campbell IL, et al. (1995). Induction of acute phase gene expression by brain irradiation. Int J Radiat Oncol Biol Phys 33:619–26.
- Hong S-S, Oh KT, Choi H-G, Lim SJ. (2019). Liposomal formulations for nose-to-brain delivery: recent advances and future perspectives. Pharmaceutics 11:540.
- Hu S, Peng R, Wang C, et al. (2014). Neuroprotective effects of dietary supplement Kang-fu-ling against high-power microwave through antioxidant action. Food Funct 5:2243–51.
- Hua K, Schindler MK, McQuail JA, et al. (2012). Regionally distinct responses of microglia and glial progenitor cells to whole brain irradiation in adult and aging rats. PloS One 7:e52728.
- Hwang S-Y, Jung J-S, Kim T-H, et al. (2006). Ionizing radiation induces astrocyte gliosis through microglia activation. Neurobiol Dis 21:457–67.
- Imaizumi N, Monnier Y, Hegi M, et al. (2010). Radiotherapy suppresses angiogenesis in mice through TGF-betaRI/ALK5-dependent inhibition of endothelial cell sprouting. PloS One 5:e11084.
- Iqubal A, Ahmed M, Iqubal MK, et al. (2021). Polyphenols as potential therapeutics for pain and inflammation in spinal cord injury. CMP 14:714–30.
- Iqubal A, Bansal P, Iqubal MK, et al. (2022). An overview and therapeutic promise of nutraceuticals against sports-related brain injury. CMP 15:3–22.
- Iqubal A, Iqubal MK, Ahmed M, Haque SE. (2021). Natural products, a potential therapeutic modality in management and treatment of nCoV-19 infection: preclinical and clinical based evidence. Curr Pharm Des 27:1153–69.
- Iqubal A, Iqubal MK, Fazal SA, et al. (2022). Nutraceuticals and their derived nano-formulations for the prevention and treatment of Alzheimer’s disease. CMP 15:23–50.
- Iqubal A, Rahman SO, Ahmed M, et al. (2021). Current quest in natural bioactive compounds for Alzheimer’s disease: multi-targeted-designed-ligand based approach with preclinical and clinical based evidence. Curr Drug Targets 22:685–720.
- Iqubal A, Sharma S, Najmi AK, et al. (2019). Nerolidol ameliorates cyclophosphamide-induced oxidative stress, neuroinflammation and cognitive dysfunction: plausible role of Nrf2 and NF- κB. Life Sci 236:116867.
- Iqubal A, Sharma S, Sharma K, et al. (2018). Intranasally administered pitavastatin ameliorates pentylenetetrazol-induced neuroinflammation, oxidative stress and cognitive dysfunction. Life Sci 211:172–81.
- Iqubal A, Syed MA, Ali J, et al. (2020). Nerolidol protects the liver against cyclophosphamide-induced hepatic inflammation, apoptosis, and fibrosis via modulation of Nrf2, NF-κB p65, and caspase-3 signaling molecules in Swiss albino mice. Biofactors 46:963–73.
- Iqubal A, Syed MA, Haque MM, et al. (2020). Effect of nerolidol on cyclophosphamide-induced bone marrow and hematologic toxicity in Swiss albino mice. Exp Hematol 82:24–32.
- Iqubal A, Syed MA, Najmi AK, et al. (2020). Nano-engineered nerolidol loaded lipid carrier delivery system attenuates cyclophosphamide neurotoxicity - probable role of NLRP3 inflammasome and caspase-1. Exp Neurol 334:113464.
- Iqubal A, Wasim M, Ashraf M, et al. (2021). Natural bioactive as a potential therapeutic approach for the management of cyclophosphamide-induced cardiotoxicity. CTMC 21:2647–70.
- Iqubal MK, Chaudhuri A, Iqubal A, et al. (2021). Targeted delivery of natural bioactives and lipid-nanocargos against signaling pathways involved in skin cancer. CMC 28:8003–35.
- Jeggo P, Löbrich M. (2006). Radiation-induced DNA damage responses. Radiat Prot Dosimetry 122:124–7.
- Jenrow KA, Brown SL, Liu J, et al. (2010). Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus. Radiat Oncol 5:1–8.
- Ji J, Cheng X, Lian L, et al. (2015). Tongqiao stasis method on retinal vascular endothelial and optic nerve injury in rats and the preventive effect of radiation. J Guangzhou Univ Tradit Chin Med 32:715–9.
- Ji S, Wu H, Ding X, et al. (2020). Increased hippocampal TrkA expression ameliorates cranial radiation‑induced neurogenesis impairment and cognitive deficit via PI3K/AKT signaling. Oncol Rep 44:2527–36.
- Jiang X, Wang X, Shang X, et al. (2001). Protective effects of Cistanche glycosides on ultrastructure of sensitive organs of 60 Co irradiated mice. Northwest Pharm J 16:66–7.
- Johannesen TB, Lien HH, Hole KH, Lote K. (2003). Radiological and clinical assessment of long-term brain tumour survivors after radiotherapy. Radiother Oncol 69:169–76.
- Kale A, Piskin Ö, Bas Y, et al. (2018). Neuroprotective effects of Quercetin on radiation-induced brain injury in rats. J Radiat Res 59:404–10.
- Kalm M, Fukuda A, Fukuda H, et al. (2009). Transient inflammation in neurogenic regions after irradiation of the developing brain. Radiat Res 171:66–76.
- Khadka B, Lee J-Y, Park DH, et al. (2020). The role of natural compounds and their nanocarriers in the treatment of CNS inflammation. Biomolecules 10:1401.
- Khan SA, Rehman S, Nabi B, et al. (2020). Boosting the brain delivery of Atazanavir through nanostructured lipid carrier-based approach for mitigating neuroaids. Pharmaceutics 12:1059.
- Khan SY, Awad EM, Oszwald A, et al. (2017). Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin. Sci Rep 7:39501–13.
- Kim JH, Brown SL, Jenrow KA, Ryu S. (2008). Mechanisms of radiation-induced brain toxicity and implications for future clinical trials. J Neurooncol 87:279–86.
- Kim MJ, Rehman SU, Amin FU, Kim MO. (2017). Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against Aβ1-42-induced neuroinflammation and neurodegeneration via the NF-KB /JNK/GSK3β signaling pathway. Nanomedicine 13:2533–44.
- Kim SH, Lim DJ, Chung YG, et al. (2002). Expression of TNF-alpha and TGF-beta 1 in the rat brain after a single high-dose irradiation. J Korean Med Sci 17:242–8.
- Kłos J, van Laar PJ, Sinnige PF, et al. (2019). Quantifying effects of radiotherapy-induced microvascular injury; review of established and emerging brain MRI techniques. Radiother Oncol 140:41–53.
- Kyrkanides S, Moore AH, Olschowka JA, et al. (2002). Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury. Brain Res Mol Brain Res 104:159–69.
- Kyrkanides S, Olschowka JA, Williams JP, et al. (1999). TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury. J Neuroimmunol 95:95–106.
- Kyrkanides S, Olschowka JA, Williams JP, et al. (1999). TNFα and IL-1β mediate intercellular adhesion molecule-1 induction via microglia–astrocyte interaction in CNS radiation injury. J Neuroimmunol 95:95–106.
- Lai F, Schlich M, Sinico C, et al. Liposomes as brain targeted delivery systems. In: Nanomedicines for brain drug delivery. New York: Springer; 2021, 29–59.
- Lee WH, Cho HJ, Sonntag WE, Lee YW. (2011). Radiation attenuates physiological angiogenesis by differential expression of VEGF, Ang-1, tie-2 and Ang-2 in rat brain. Radiat Res 176:753–60.
- Lee WH, Sonntag WE, Mitschelen M, et al. (2010). Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain. Int J Radiat Biol 86:132–44.
- Lee WH, Warrington JP, Sonntag WE, et al. (2012). Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brain. Int J Radiat Oncol Biol Phys 82:1559–66.
- Lee YW, Cho HJ, Lee WH, Sonntag WE. (2012). Whole brain radiation-induced cognitive impairment: pathophysiological mechanisms and therapeutic targets. Biomol Ther (Seoul) 20:357–70.
- Lei D, Sha Y, Wen S, et al. (2020). Dexmedetomidine may reduce IL-6 level and the risk of postoperative cognitive dysfunction in patients after surgery: a meta-analysis. Dose Response 18:1559325820902345.
- Lei S, Adams M, Long A, et al. (2006). Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus. Radiat Res 166:892–9.
- Li B, Feng J, Chen L, et al. (2021). Relapse pattern and quality of life in patients with localized basal ganglia germinoma receiving focal radiotherapy, whole-brain radiotherapy, or craniospinal irradiation. Radiother Oncol 158:90–6.
- Li W, Cao Z, Liu R, et al. (2019). AuNPs as an important inorganic nanoparticle applied in drug carrier systems. Artif Cells Nanomed Biotechnol 47:4222–33.
- Li Y, An C, Han D, et al. (2018). Neutrophil affinity for PGP and HAIYPRH (T7) peptide dual-ligand functionalized nanoformulation enhances the brain delivery of tanshinone IIA and exerts neuroprotective effects against ischemic stroke by inhibiting proinflammatory signaling pathways. New J Chem 42:19043–61.
- Li Y, Lyu P, Ze Y, et al. (2021). Exosomes derived from plasma: promising immunomodulatory agents for promoting angiogenesis to treat radiation-induced vascular dysfunction. PeerJ 9:e11147.
- Li Y, Tan J, Wang J. (2010). The radiation-protective effect of radix hedysari capsules on mice. Pharm J Chin People’s Libration Army 26:400–2.
- Li Y-Q, Chen P, Haimovitz-Friedman A, et al. (2003). Endothelial apoptosis initiates acute blood–brain barrier disruption after ionizing radiation. Cancer Res 63:5950–6.
- Limoli CL, Giedzinski E, Rola R, et al. (2004). Radiation response of neural precursor cells: linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress. Radiat Res 161:17–27.
- Liu X, Ye M, An C, et al. (2013). The effect of cationic albumin-conjugated PEGylated tanshinone IIA nanoparticles on neuronal signal pathways and neuroprotection in cerebral ischemia. Biomaterials 34:6893–905.
- Liu Y, Xiao S, Liu J, et al. (2010). An experimental study of acute radiation-induced cognitive dysfunction in a young rat model. AJNR Am J Neuroradiol 31:383–7.
- Liu Y-Q, Wang X-L, He D-H, et al. (2021). Protection against chemotherapy- and radiotherapy-induced side effects: a review based on the mechanisms and therapeutic opportunities of phytochemicals. Phytomedicine 80:153402.
- Loncaster JA, Cooper RA, Logue JP, et al. (2000). Vascular endothelial growth factor (VEGF) expression is a prognostic factor for radiotherapy outcome in advanced carcinoma of the cervix. Br J Cancer 83:620–5.
- Lumniczky K, Szatmári T, Sáfrány G. (2017). Ionizing radiation-induced immune and inflammatory reactions in the brain. Front Immunol 8:517.
- Lupattelli M, Alì E, Ingrosso G, et al. (2020). Stereotactic radiotherapy for brain metastases: imaging tools and dosimetric predictive factors for radionecrosis. JPM 10:59.
- Maiyo F, Singh M. (2017). Selenium nanoparticles: potential in cancer gene and drug delivery. Nanomedicine (Lond) 12:1075–89.
- Makale MT, McDonald CR, Hattangadi-Gluth J, Kesari S. (2017). Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours. Nat Rev Neurol 13:52–64.
- Makale MT, McDonald CR, Hattangadi-Gluth JA, Kesari S. (2017). Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours. Nat Rev Neurol 13:52–64.
- Manda K, Ueno M, Anzai K. (2009). Cranial irradiation-induced inhibition of neurogenesis in hippocampal dentate gyrus of adult mice: attenuation by melatonin pretreatment. J Pineal Res 46:71–8.
- Manda K, Ueno M, Moritake T, et al. (2007). Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: protective effect of alpha-lipoic acid. Behav Brain Res 177:7–14.
- Manek E, Petroianu GA. (2021). Brain delivery of antidotes by polymeric nanoparticles. J Appl Toxicol 41:20–32.
- Mansour SZ, Moawed FS, Elmarkaby SM. (2017). Protective effect of 5, 7-dihydroxyflavone on brain of rats exposed to acrylamide or γ-radiation. J Photochem Photobiol B 175:149–55.
- Md S, Alhakamy NA, Alfaleh MA, et al. (2021). Mechanisms involved in microglial-interceded Alzheimer’s disease and nanocarrier-based treatment approaches. JPM 11:1116.
- Meng F, Asghar S, Gao S, et al. (2015). A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer’s disease. Colloids Surf B Biointerfaces 134:88–97.
- Meng Q, Wang A, Hua H, et al. (2018). Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer’s disease. Int J Nanomed 13:705–18.
- Meyers CA, Brown PD. (2006). Role and relevance of neurocognitive assessment in clinical trials of patients with CNS tumors. J Clin Oncol 24:1305–9.
- Miller KD, Ostrom QT, Kruchko C, et al. (2021). Brain and other central nervous system tumor statistics, 2021. CA Cancer J Clin 71:381–406.
- Mizumatsu S, Monje ML, Morhardt DR, et al. (2003). Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res 63:4021–7.
- Mohamed HA, Said RS. (2021). Coenzyme Q10 attenuates inflammation and fibrosis implicated in radiation enteropathy through suppression of NF-kB/TGF-β/MMP-9 pathways. Int Immunopharmacol 92:107347.
- Monje ML, Toda H, Palmer TD. (2003). Inflammatory blockade restores adult hippocampal neurogenesis. Science 302:1760–5.
- Mou J, Zheng H, Zhang C. (2004). Effect of compound salvia miltiorrhiza injection on prevention of acute radiationinduced brain injury. Sichuan Tumor Prevention 17:181–2.
- Nagpal K, Singh SK, Mishra DN. (2010). Chitosan nanoparticles: a promising system in novel drug delivery. Chem Pharm Bull (Tokyo) 58:1423–30.
- Nehal N, Nabi B, Rehman S, et al. (2021). Chitosan coated synergistically engineered nanoemulsion of Ropinirole and nigella oil in the management of Parkinson’s disease: formulation perspective and in vitro and in vivo assessment. Int J Biol Macromol 167:605–19.
- Ngo D-H, Kim S-K. (2014). Antioxidant effects of chitin, chitosan, and their derivatives. Adv Food Nutr Res 73:15–31.
- Nieblas-Bedolla E, Nayyar N, Singh M, et al. (2021). Emerging immunotherapies in the treatment of brain metastases. Oncologist 26:231–41.
- Niranjan R. (2013). Molecular basis of etiological implications in Alzheimer’s disease: focus on neuroinflammation. Mol Neurobiol 48:412–28.
- Nizamutdinova IT, Kim YM, Chung JI, et al. (2009). Anthocyanins from black soybean seed coats preferentially inhibit TNF-alpha-mediated induction of VCAM-1 over ICAM-1 through the regulation of GATAs and IRF-1. J Agric Food Chem 57:7324–30.
- Oh SB, Park HR, Jang YJ, et al. (2013). Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiation. Br J Pharmacol 168:421–31.
- Olschowka JA, Kyrkanides S, Harvey BK, et al. (1997). ICAM-1 induction in the mouse CNS following irradiation. Brain Behav Immun 11:273–85.
- Pakzad A, Obad N, Espedal H, et al. (2014). Bevacizumab treatment for human glioblastoma. Can it induce cognitive impairment? Neuro Oncol 16:754–6.
- Papadia K, Giannou AD, Markoutsa E, et al. (2017). Multifunctional LUV liposomes decorated for BBB and amyloid targeting - B. In vivo brain targeting potential in wild-type and APP/PS1 mice. Eur J Pharm Sci 102:180–7.
- Pazzaglia S, Briganti G, Mancuso M, Saran A. (2020). Neurocognitive decline following radiotherapy: mechanisms and therapeutic implications. Cancers 12:146.
- Peng W, Chen N, Hu X, et al. (2021). Prevention and treatment of cognitive dysfunction caused by radiotherapy to the brain. J Int Oncol 48:52–6.
- Peng XC, Huang JR, Wang SW, et al. (2018). Traditional Chinese medicine in neuroprotection after brain insults with special reference to radioprotection. Evid Based Complement Alternat Med 2018:2767208.
- Piazzini V, Landucci E, Graverini G, et al. (2018). Stealth and cationic nanoliposomes as drug delivery systems to increase andrographolide BBB permeability. Pharmaceutics 10:128.
- Plant-Fox AS, O’Halloran K, Goldman S. (2021). Pediatric brain tumors: the era of molecular diagnostics, targeted and immune-based therapeutics, and a focus on long term neurologic sequelae. Curr Probl Cancer 45:100777.
- Quimby FW, Luong RH. (2007). Clinical chemistry of the laboratory mouse. In: The mouse in biomedical research. Burlington (MA): Elsevier, 171–216.
- Radhakrishna V, Nanilu SK, Sanjeev G, et al. (2017). Evaluation of the potency of kinetin on radiation induced behavioural changes in Swiss albino mice. J Clin Diagn Res 11:TF01–TF04.
- Raghavapudi H, Singroul P, Kohila V. (2021). Brain tumor causes, symptoms, diagnosis and radiotherapy treatment. Curr Med Imaging 17:931–42.
- Ramanan S, Kooshki M, Zhao W, et al. (2008). PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways. Free Radic Biol Med 45:1695–704.
- Ribeiro M, Durand T, Roussel M, et al. (2020). Sensitivity of the Montreal Cognitive Assessment in screening for cognitive impairment in patients with newly diagnosed high-grade glioma. J Neurooncol 148:335–42.
- Robbins M, Greene-Schloesser D, Peiffer AM, et al. (2012). Radiation-induced brain injury: a review. Front Oncol 2:73.
- Robbins ME, Zhao W, Davis CS, et al. (2002). Radiation-induced kidney injury: a role for chronic oxidative stress? Micron 33:133–41.
- Rochfort KD, Cummins PM. (2015). The blood-brain barrier endothelium: a target for pro-inflammatory cytokines. Biochem Soc Trans 43:702–6.
- Rola R, Raber J, Rizk A, et al. (2004). Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp Neurol 188:316–30.
- Rolle T, Ponzetto A, Malinverni L. (2020). The role of neuroinflammation in glaucoma: An update on molecular mechanisms and new therapeutic options. Front Neurol 11:612422.
- Rubin P, Gash D, Hansen J, et al. (1994). Disruption of the blood-brain barrier as the primary effect of CNS irradiation. Radiother Oncol 31:51–60.
- Schindler MK, Forbes ME, Robbins ME, Riddle DR. (2008). Aging-dependent changes in the radiation response of the adult rat brain. Int J Radiat Oncol Biol Phys 70:826–34.
- Schmal Z, Hammer B, Müller A, Rübe CE et al. (2021). Fractionated low-dose radiation induces long-lasting inflammatory responses in the hippocampal stem cell niche. Int J Radiat Oncol Biol Phys 111:1262–75.
- Sharp CD, Jawahar A, Warren AC, et al. (2003). Gamma knife irradiation increases cerebral endothelial expression of intercellular adhesion molecule 1 and E-selectin. Neurosurgery 53:154–61.
- Shi X-X, Miao W-M, Pang D-W, et al. (2020). Angiopep-2 conjugated nanoparticles loaded with doxorubicin for the treatment of primary central nervous system lymphoma. Biomater Sci 8:1290–7.
- Sikorska M, Lanthier P, Miller H, et al. (2014). Nanomicellar formulation of coenzyme Q10 (Ubisol-Q10) effectively blocks ongoing neurodegeneration in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model: potential use as an adjuvant treatment in Parkinson’s disease. Neurobiol Aging 35:2329–46.
- Sonkar R, Jha A, Viswanadh MK, et al. (2021). Gold liposomes for brain-targeted drug delivery: Formulation and brain distribution kinetics. Mater Sci Eng C 120:111652.
- Sourati A, Ameri A, Malekzadeh M. (2017). Radiation brain injury. In: Acute side effects of radiation therapy. Cham: Springer, 27–37.
- Srinageshwar B, Dils A, Sturgis J, et al. (2019). Surface-modified G4 pamam dendrimers cross the blood-brain barrier following multiple tail-vein injections in C57BL/6J mice. ACS Chem Neurosci 10:4145–50.
- Storkebaum E, Lambrechts D, Carmeliet P. (2004). VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. Bioessays 26:943–54.
- Subramaniam B, Siddik ZH, Nagoor NH. (2020). Optimization of nanostructured lipid carriers: Understanding the types, designs, and parameters in the process of formulations. J Nanopart Res 22:1–29.
- Sultana N, Sun C, Katsube T, Wang B. (2020). Biomarkers of brain damage induced by radiotherapy. Dose Response 18:1559325820938279.
- Sun A, Chuangang L, Lin S, et al. (2014). The importance of regulatory role of panaxoside Rg1 in Cdk5 on hippocampal neuron radioactive damage protection. J Chin Phys 16:584–7.
- Sun J, Wei C, Liu Y, et al. (2019). Progressive release of mesoporous nano-selenium delivery system for the multi-channel synergistic treatment of Alzheimer’s disease. Biomaterials 197:417–31.
- Tang H-H, Chen Y, Luo J. (2010). Protective effect of astragalus injection on radiation injury in primary cultured rat hippocampal neuron. Chin J Cancer Prev Treat 17:1049–51.
- Teleanu DM, Chircov C, Grumezescu AM, et al. (2018). Blood-brain delivery methods using nanotechnology. Pharmaceutics 10:269.
- Thabet NM, Moustafa EM. (2018). Protective effect of rutin against brain injury induced by acrylamide or gamma radiation: role of PI3K/AKT/GSK-3β/NRF-2 signalling pathway. Arch Physiol Biochem 124:185–93.
- Tofilon PJ, Fike JR. (2000). The radioresponse of the central nervous system: a dynamic process. Radiat Res 153:357–70.
- Tuli HS, Mittal S, Aggarwal D, et al. (2021). Path of Silibinin from diet to medicine: A dietary polyphenolic flavonoid having potential anti-cancer therapeutic significance. Semin Cancer Biol 73:196–218..
- Turnquist C, Harris BT, Harris CC. (2020). Radiation-induced brain injury: current concepts and therapeutic strategies targeting neuroinflammation. Neurooncol Adv 2:vdaa057.
- Veeraraghavan J, Natarajan M, Herman TS, Aravindan N. (2011). Low-dose γ-radiation-induced oxidative stress response in mouse brain and gut: regulation by NFκB-MnSOD cross-signaling. Mutat Res 718:44–55.
- Wang Q, Xie C, Xi S, et al. (2020). Radioprotective effect of flavonoids on ionizing radiation-induced brain damage. Molecules 25:5719.
- Wang Y, Zhou K, Li T, et al. (2017). Inhibition of autophagy prevents irradiation-induced neural stem and progenitor cell death in the juvenile mouse brain. Cell Death Dis 8:e2694–e2694.
- Wang Z-Y, Sreenivasmurthy SG, Song J-X, et al. (2019). Strategies for brain-targeting liposomal delivery of small hydrophobic molecules in the treatment of neurodegenerative diseases. Drug Discov Today 24:595–605.
- Ward J. (1990). The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review. Int J Radiat Biol 57:1141–50.
- Warrington JP, Ashpole N, Csiszar A, et al. (2013). Whole brain radiation-induced vascular cognitive impairment: mechanisms and implications. J Vasc Res 50:445–57.
- Warrington JP, Csiszar A, Mitschelen M, et al. (2012). Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia. PloS One 7:e30444.
- Wong CS, Van der Kogel AJ. (2004). Mechanisms of radiation injury to the central nervous system: implications for neuroprotection. Mol Interv 4:273–84.
- Xiao C, Beitler JJ, Peng G, et al. (2021). Epigenetic age acceleration, fatigue, and inflammation in patients undergoing radiation therapy for head and neck cancer: a longitudinal study. Cancer 127:3361–71.
- Xiao Y, Chen Y. (2005). Interventional effect of astragale parenteral solution on the cognitive ability and behavioral changes of rats with acute radioactive injury. Chin J Clin Rehabil 9:71–3.
- Yang B, Zhang L-Y, Chen Y, et al. (2020). Melatonin alleviates intestinal injury, neuroinflammation and cognitive dysfunction caused by intestinal ischemia/reperfusion. Int Immunopharmacol 85:106596.
- Yasir M, Sara UVS. (2014). Solid lipid nanoparticles for nose to brain delivery of haloperidol: in vitro drug release and pharmacokinetics evaluation. Acta Pharm Sin B 4:454–63.
- Yi J, Miao Y, Yang W, et al. (2004). Radiation-induced late brain injury and the protective effect of traditional Chinese medicine. Chin J Radiat Oncol 13:107–10.
- Yin T, Yang L, Liu Y, et al. (2015). Sialic acid (SA)-modified selenium nanoparticles coated with a high blood-brain barrier permeability peptide-B6 peptide for potential use in Alzheimer’s disease. Acta Biomater 25:172–83.
- Zhang J, Tong F, Cai Q, et al. (2015). Shenqi Fuzheng Injection attenuates irradiation-induced brain injury in mice via inhibition of the NF-κB signaling pathway and microglial activation. Acta Pharmacol Sin 36:1288–99.
- Zhang J, Zhang X, Yi S. (1999). Neuronal damage in hippocampus (CA-1) region after microwave radiation with and without salvia miltiorrhiza treatment. Chin J Neurosurg 15:18–20.
- Zhang L, Yang H, Tian Y. (2015). Radiation-induced cognitive impairment. In: Therapeutic targets for neurological diseases, 2. Texas: Ther Tar Neurol Dis.
- Zhang Q-Y, Wang F-X, Jia K-K, Kong L-D, et al. (2018). Natural product interventions for chemotherapy and radiotherapy-induced side effects. Front Pharmacol 9:1253.
- Zhao Z, Johnson MS, Chen B, et al. (2016). Live-cell imaging to detect phosphatidylserine externalization in brain endothelial cells exposed to ionizing radiation: implications for the treatment of brain arteriovenous malformations. J Neurosurg 124:1780–7.
- Zhuang S, Liu B, Guo S, et al. (2021). Germacrone alleviates neurological deficits following traumatic brain injury by modulating neuroinflammation and oxidative stress. BMC Complement Med Ther 21:6–10.