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Research Articles

Novel linezolid loaded bio-composite films as dressings for effective wound healing: experimental design, development, optimization, and antimicrobial activity

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Pages 3168-3185 | Received 10 Aug 2022, Accepted 18 Sep 2022, Published online: 02 Oct 2022

References

  • Ahmed A, Sh Mandal UK, Taher M, et al. (2018). PVA-PEG physically cross-linked hydrogel film as a wound dressing: experimental design and optimization. Pharm Dev Technol 23:751–60. https://doi.org/10.1080/10837450.2017.1295067.
  • Akbari J, Saeedi M, Morteza-Semnani K, et al. (2015). The effect of Tween 20, 60, and 80 on dissolution behavior of sprionolactone in solid dispersions prepared by PEG 6000. Adv Pharm Bull 5:435–41. https://doi.org/10.15171/apb.2015.059.
  • Arvanitoyannis IS, Nakayama A, Aiba S. (1998). Chitosan and gelatin based edible films: state diagrams, mechanical and permeation properties. Carbohydr. Polym 37:371–82. https://doi.org/10.1016/S0144-8617(98)00083-6.
  • Ashfaq M, Shah S, Rasul A, et al. (2022). Enhancement of the solubility and bioavailability of pitavastatin through a self-nanoemulsifying drug delivery system (SNEDDS). Pharmaceutics 14:482. https://doi.org/10.3390/pharmaceutics14030482.
  • Azevedo EP, Saldanha TDP, Navarro MVM, et al. (2006). Mechanical properties and release studies of chitosan films impregnated with silver sulfadiazine. J Appl Polym Sci 102:3462–70. https://doi.org/10.1002/app.24537.
  • Bajdik J, Marciello M, Caramella C, et al. (2009). Evaluation of surface and microstructure of differently plasticized chitosan films. J Pharm Biomed Anal 49:655–9. https://doi.org/10.1016/j.jpba.2008.12.020.
  • Bakr RO, Amer RI, Attia D, et al. (2021). In-vivo wound healing activity of a novel composite sponge loaded with mucilage and lipoidal matter of hibiscus species. Biomed. Pharmacother. Biomedecine Pharmacother 135:111225. https://doi.org/10.1016/j.biopha.2021.111225.
  • Bassi P, Kaur G. (2017). Polymeric films as a promising carrier for bioadhesive drug delivery: development, characterization and optimization. Saudi Pharm J 25:32–43. https://doi.org/10.1016/j.jsps.2015.06.003.
  • Benninghoven A. Ion formation from organic solids (IFOS III): mass spectrometry of involatile material. In Proceedings of the Third International Conference Monster, Fed. Rep. of Germany, September 16-18, 1985, Softcover reprint of the original 1st ed. 1986 edition. Springer Science & Business Media, 2012.
  • Bhagurkar AM, Darji M, Lakhani P, et al. (2019). Effects of formulation composition on the characteristics of mucoadhesive films prepared by hot-melt extrusion technology. J Pharm Pharmacol 71:293–305. https://doi.org/10.1111/jphp.13046.
  • Boateng JS, Pawar HV, Tetteh J. (2013). Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing. Int J Pharm 441:181–91. https://doi.org/10.1016/j.ijpharm.2012.11.045.
  • Boncu E, Uskudar Guclu T, Catma A, et al. (2020). In vitro and in vivo evaluation of linezolid loaded electrospun PLGA and PLGA/PCL fiber mats for prophylaxis and treatment of MRSA induced prosthetic infections. Int. J. Pharm 573:118758. https://doi.org/10.1016/j.ijpharm.2019.118758.
  • Carreño G, Marican A, Vijayakumar S, et al. (2020). Sustained release of linezolid from prepared hydrogels with polyvinyl alcohol and aliphatic dicarboxylic acids of variable chain lengths. Pharmaceutics 12:982. https://doi.org/10.3390/pharmaceutics12100982.
  • Cerqueira MA, Souza BWS, Teixeira JA, Vicente AA. (2012). Effect of glycerol and corn oil on physicochemical properties of polysaccharide films – a comparative study. Food Hydrocoll 27:175–84. https://doi.org/10.1016/j.foodhyd.2011.07.007.
  • Colobatiu L, Gavan A, Mocan A, et al. (2019). Development of bioactive compounds-loaded chitosan films by using a QbD approach – a novel and potential wound dressing material. React. Funct. Polym 138:46–54. https://doi.org/10.1016/j.reactfunctpolym.2019.02.013.
  • Conzatti G, Chamary S, De Geyter N, et al. (2018). Surface functionalization of plasticized chitosan films through PNIPAM grafting via UV and plasma graft polymerization. Eur. Polym. J 105:434–41. https://doi.org/10.1016/j.eurpolymj.2018.06.020.
  • Domján A, Bajdik J, Pintye-Hódi K. (2009). Understanding of the plasticizing effects of glycerol and PEG 400 on chitosan films using solid-state NMR spectroscopy. Macromolecules 42:4667–73. https://doi.org/10.1021/ma8021234.
  • Ediyilyam S, George B, Shankar SS, et al. (2021). Chitosan/gelatin/silver nanoparticles composites films for biodegradable food packaging applications. Polymers 13:1680. https://doi.org/10.3390/polym13111680.
  • Francois N, Debandi M. (2016). Development of biodegradable films based on chitosan/glycerol blends suitable for biomedical applications. J. Tissue Sci. Eng 7:187. https://doi.org/10.4172/2157-7552.1000187.
  • Ghasemlou M, Khodaiyan F, Oromiehie A. (2011). Physical, mechanical, barrier, and thermal properties of polyol-plasticized biodegradable edible film made from Kefiran. Carbohydr. Polym 84:477–83. https://doi.org/10.1016/j.carbpol.2010.12.010.
  • Ghosal K, Das A, Das SK, et al. (2019). Synthesis and characterization of interpenetrating polymeric networks based bio-composite alginate film: a well-designed drug delivery platform. Int J Biol Macromol 130:645–54. https://doi.org/10.1016/j.ijbiomac.2019.02.117.
  • Hafezi F, Scoutaris N, Douroumis D, Boateng J. (2019). 3D printed chitosan dressing crosslinked with genipin for potential healing of chronic wounds. Int J Pharm 560:406–15. https://doi.org/10.1016/j.ijpharm.2019.02.020.
  • Haider F, Khan BA, Khan MK. (2022). Formulation and evaluation of topical linezolid nanoemulsion for open incision wound in diabetic animal model. AAPS PharmSciTech 23:129. https://doi.org/10.1208/s12249-022-02288-8.
  • Hedaya MA, Thomas V, Abdel-Hamid ME, et al. (2017). Comparative pharmacokinetic study for linezolid and two novel antibacterial oxazolidinone derivatives in rabbits: can differences in the pharmacokinetic properties explain the discrepancies between their in vivo and in vitro antibacterial activities? Pharmaceutics 9:34. https://doi.org/10.3390/pharmaceutics9030034.
  • Ibrahim YH-EY, Regdon G, Kristó K, et al. (2020). Design and characterization of chitosan/citrate films as carrier for oral macromolecule delivery. Eur J Pharm Sci 146:105270. https://doi.org/10.1016/j.ejps.2020.105270.
  • Issa A, Abidin M, Sobri ZZ, et al. (2020). Fabrication, characterization and response surface method optimization for quantum efficiency of fluorescent nitrogen-doped carbon dots obtained from carboxymethylcellulose of oil palms empty fruit bunch. Chin. J. Chem. Eng 28:584–92. https://doi.org/10.1016/j.cjche.2019.04.003.
  • Jantrawut P, Chaiwarit T, Jantanasakulwong K, et al. (2017). Effect of plasticizer type on tensile property and in vitro indomethacin release of thin films based on low-methoxyl pectin. Polymers 9:289. https://doi.org/10.3390/polym9070289.
  • Jung J, Deng Z, Simonsen J, et al. (2016). Development and preliminary field validation of water-resistant cellulose nanofiber based coatings with high surface adhesion and elasticity for reducing cherry rain-cracking. Sci. Hortic 200:161–9. https://doi.org/10.1016/j.scienta.2016.01.016.
  • Kan J, Liu J, Yong H, et al. (2019). Development of active packaging based on chitosan-gelatin blend films functionalized with Chinese hawthorn (Crataegus Pinnatifida) fruit extract. Int J Biol Macromol 140:384–92. https://doi.org/10.1016/j.ijbiomac.2019.08.155.
  • Lamim R, de Freitas RA, Rudek EI, et al. (2006). Films of chitosan and N-carboxymethylchitosan. Part II: effect of plasticizers on their physiochemical properties. Polym Int 55:970–7. https://doi.org/10.1002/pi.1959.
  • Li B, Wang J, Gui Q, Yang H. (2020). Drug-loaded chitosan film prepared via facile solution casting and air-drying of plain water-based chitosan solution for ocular drug delivery. Bioact Mater 5:577–83. 5https://doi.org/10.1016/j.bioactmat.2020.04.013.
  • Liu Z, Ge X, Lu Y, et al. (2012). Effects of chitosan molecular weight and degree of deacetylation on the properties of gelatine-based films. Food Hydrocoll 26:311–7. https://doi.org/10.1016/j.foodhyd.2011.06.008.
  • Ma J-L, Gao L, L, X, Chu, et al. (2015). Comparison of the pharmacokinetics of linezolid in burn and non-burn rabbits. Eur J Drug Metab Pharmacokinet 40:355–61. https://doi.org/10.1007/s13318-014-0209-6.
  • Ma Y, Xin L, Tan H, et al. (2017). Chitosan membrane dressings toughened by glycerol to load antibacterial drugs for wound healing. Mater Sci Eng C Mater Biol Appl 81:522–31. https://doi.org/10.1016/j.msec.2017.08.052.
  • Manshor NM, Rezali MI, Jai J, Yahya A. (2018). Effect of plasticizers on physicochemical and mechanical properties of chitosan-gelatin films. IOP Conf Ser: Mater Sci Eng 358:012040. https://doi.org/10.1088/1757-899X/358/1/012040.
  • Naomi R, Bahari H, Ridzuan PM, Othman F. (2021). Natural-based biomaterial for skin wound healing (Gelatin vs. Collagen): expert review. Polymers 13:2319. https://doi.org/10.3390/polym13142319.
  • Pawar HV, Tetteh J, Boateng J, S. (2013). Preparation, optimisation and characterisation of novel wound healing film dressings loaded with streptomycin and diclofenac. Colloids Surf. B Biointerfaces 102:102–10. https://doi.org/10.1016/j.colsurfb.2012.08.014.
  • Proaño JL, Salgado PR, Cian RE, et al. (2020). Physical, structural and antioxidant properties of Brewer’s spent grain protein films. J Sci Food Agric 100:5458–65. https://doi.org/10.1002/jsfa.10597.
  • Rancan F, Jurisch J, Günday C, et al. (2021). Screening of surfactants for improved delivery of antimicrobials and poly-lactic-co-glycolic acid particles in wound tissue. Pharmaceutics 13:1093. https://doi.org/10.3390/pharmaceutics13071093.
  • Reddy AB, Manjula B, Jayaramudu T, et al. (2016). 5-Fluorouracil loaded chitosan–PVA/Na + MMT nanocomposite films for drug release and antimicrobial activity. Nanomicro Lett 8:260–9. https://doi.org/10.1007/s40820-016-0086-4.
  • Rivero S, Damonte L, García M, Pinotti A. (2016). An insight into the role of glycerol in chitosan films. Food Biophys 11:117–7. https://doi.org/10.1007/s11483-015-9421-4.
  • Sanyang ML, Sapuan SM, Jawaid M, et al. (2016). Effect of plasticizer type and concentration on physical properties of biodegradable films based on sugar palm (Arenga Pinnata) starch for food packaging. J Food Sci Technol 53:326–36. https://doi.org/10.1007/s13197-015-2009-7.
  • Shah S, Maheshwari H, Soniwala M, Chavda J. (2022). Pulmonary delivery of linezolid nanoparticles for treatment of tuberculosis: design, development, and optimization. J Pharm Innov 17:46–59. https://doi.org/10.1007/s12247-020-09491-9.
  • Shamma R, Elkasabgy N. (2016). Design of freeze-dried soluplus/polyvinyl alcohol-based film for the oral delivery of an insoluble drug for the pediatric use. Drug Deliv 23:489–99. https://doi.org/10.3109/10717544.2014.921944.
  • Singh P, Khan T, Ahmad F, et al. (2021). Development of chitosan edible coatings incorporated with clove essential oil nanoemulsions and its effect on shelf life of fresh-cut mangoes. Songklanakarin J. Sci. Technol 43:1360–6.
  • Song HJ, Tang KY. (2011). Effects of various plasticizers on the moisture sorption and mechanical properties of gelatin-chitosan composite films. Adv. Mater. Res 295–297:1202–5. https://doi.org/10.4028/www.scientific.net/AMR.295-297.1202.
  • Sun Y, Liu Z, Zhang L, et al. (2020). Effects of plasticizer type and concentration on rheological, physico-mechanical and structural properties of chitosan/zein film. Int J Biol Macromol 143:334–40. https://doi.org/10.1016/j.ijbiomac.2019.12.035.
  • Suyatma NE, Tighzert L, Copinet A, Coma V. (2005). Effects of hydrophilic plasticizers on mechanical, thermal, and surface properties of chitosan films. J Agric Food Chem 53:3950–7. https://doi.org/10.1021/jf048790+.
  • Üstündağ Okur N, Filippousi M, Okur ME, et al. (2018). A Novel approach for skin infections: controlled release topical mats of poly(lactic acid)/poly(ethylene succinate) blends containing voriconazole. J. Drug Deliv. Sci. Technol 46:74–86. https://doi.org/10.1016/j.jddst.2018.05.005.
  • Üstündağ Okur N, Hökenek N, Okur ME, et al. (2019). An Alternative approach to wound healing field; new composite films from natural polymers for mupirocin dermal delivery. Saudi Pharm. J. SPJ off. Publ. Saudi Pharm. Soc 27:738–52. https://doi.org/10.1016/j.jsps.2019.04.010.
  • Velayutham R, Manivannan S. (2015). Wound healing potential of transdermal patches containing bioactive fraction from the bark of Ficus Racemosa. Int. J. Pharm. Pharm. Sci 7:326–32.
  • Yaghoobian M, Haeri A, Bolourchian N, et al. (2020). The impact of surfactant composition and surface charge of niosomes on the oral absorption of repaglinide as a BCS II model drug. Int J Nanomedicine 15:8767–81. https://doi.org/10.2147/IJN.S261932.
  • Zaman M, Hanif M. (2018). In vitro and ex vivo assessment of hydrophilic polymer- and plasticizer-based thin buccal films designed by using central composite rotatable design for the delivery of meloxicam. Adv Polym Technol 37:1823–36. https://doi.org/10.1002/adv.21841.
  • Zhang N, Li X, Ye J, et al. (2020). Effect of gellan gum and xanthan gum synergistic interactions and plasticizers on physical properties of plant-based enteric polymer films. Polymers 12:121. https://doi.org/10.3390/polym12010121.