Dihydroartemisinin and doxorubicin co-loaded Soluplus^®-TPGS mixed micelles: formulation characterization, cellular uptake, and pharmacodynamic studies

References

• Andreetta C, Minisini AM, Miscoria M, Puglisi F. 2010. First-line chemotherapy with or without biologic agents for metastatic breast cancer. Crit Rev Oncol Hematol. 76:99–111.
   PubMed Web of Science ®Google Scholar
• Bernabeu E, Gonzalez L, Cagel M, Gergic EP, Moretton MA, Chiappetta DA. 2016. Novel Soluplus((R))-TPGS mixed micelles for encapsulation of paclitaxel with enhanced in vitro cytotoxicity on breast and ovarian cancer cell lines. Colloids Surf B Biointerfaces. 140:403–411.
   PubMed Web of Science ®Google Scholar
• Chen HH, Zhou HJ, Wang WQ, Wu GD. 2004. Antimalarial dihydroartemisinin also inhibits angiogenesis. Cancer Chemother Pharmacol. 53:423–432.
   PubMed Web of Science ®Google Scholar
• Chen T, Chen M, Chen J. 2013a. Ionizing radiation potentiates dihydroartemisinin-induced apoptosis of A549 cells via a caspase-8-dependent pathway. PLoS One. 8:e59827.
   PubMed Web of Science ®Google Scholar
• Chen Y, Yang W, Chang B, Hu H, Fang X, Sha X. 2013b. In vivo distribution and antitumor activity of doxorubicin-loaded N-isopropylacrylamide-co-methacrylic acid coated mesoporous silica nanoparticles and safety evaluation. Eur J Pharm Biopharm. 85:406–412.
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhang W, Gu J, Ren Q, Fan Z, Zhong W, Fang X, Sha X. 2013c. Enhanced antitumor efficacy by methotrexate conjugated Pluronic mixed micelles against KBv multidrug resistant cancer. Int J Pharm. 452:421–433.
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhang W, Huang Y, Gao F, Sha X, Fang X. 2015. Pluronic-based functional polymeric mixed micelles for co-delivery of doxorubicin and paclitaxel to multidrug resistant tumor. Int J Pharm. 488:44–58.
   PubMed Web of Science ®Google Scholar
• Dilley RL, Verma P, Cho NW, Winters HD, Wondisford AR, Greenberg RA. 2016. Break-induced telomere synthesis underlies alternative telomere maintenance. Nature. 539:54–58.
   PubMed Web of Science ®Google Scholar
• Ding Y, Wang C, Wang Y, Xu Y, Zhao J, Gao M, Ding Y, Peng J, Li L. 2018. Development and evaluation of a novel drug delivery: Soluplus®/TPGS mixed micelles loaded with piperine in vitro and in vivo. Drug Dev Ind Pharm. 44:1409–1416.
   PubMed Web of Science ®Google Scholar
• Guo-Sheng W, Lu JJ, Guo JJ, Huang MQ, Gan L, Chen XP, Wang YT. 2013. Synergistic anti-cancer activity of the combination of dihydroartemisinin and doxorubicin in breast cancer cells. Pharm Rep. 65:453–459.
   PubMed Web of Science ®Google Scholar
• Guo Y, Luo J, Tan S, Otieno BO, Zhang Z. 2013. The applications of Vitamin E TPGS in drug delivery. Eur J Pharm Sci. 49:175–186.
   PubMed Web of Science ®Google Scholar
• Hou J, Wang D, Zhang R, Wang H. 2008. Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action. Clin Cancer Res. 14:5519–5530.
   PubMed Web of Science ®Google Scholar
• Hu X, Tian H, Jiang W, Song A, Li Z, Luan Y. 2018. Rational design of IR820- and Ce6-based versatile micelle for single NIR laser-induced imaging and dual-modal phototherapy. Small. 14:1802994.
   PubMed Web of Science ®Google Scholar
• Hughey JR, Keen JM, Miller DA, Kolter K, Langley N, McGinity JW. 2013. The use of inorganic salts to improve the dissolution characteristics of tablets containing Soluplus(R)-based solid dispersions. Eur J Pharm Sci. 48:758–766.
   PubMed Web of Science ®Google Scholar
• Li S, Yuan S, Zhao Q, Wang B, Wang X, Li K. 2018. Quercetin enhances chemotherapeutic effect of doxorubicin against human breast cancer cells while reducing toxic side effects of it. Biomed Pharmacother. 100:441–447.
   PubMed Web of Science ®Google Scholar
• Llach A, Mazevet M, Mateo P, Villejouvert O, Ridoux A, Rucker-Martin C, Ribeiro M, Fischmeister R, Crozatier B, Benitah JP, et al. 2018. Progression of excitation-contraction coupling defects in doxorubicin cardiotoxicity. J Mol Cell Cardiol. 126:129–139.
   PubMed Web of Science ®Google Scholar
• Lu JJ, Chen SM, Zhang XW, Ding J, Meng LH. 2011. The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells. Invest New Drugs. 29:1276–1283.
   PubMed Web of Science ®Google Scholar
• Mercer AE, Maggs JL, Sun XM, Cohen GM, Chadwick J, O’Neill PM, Park BK. 2007. Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds. J Biol Chem. 282:9372–9382.
   PubMed Web of Science ®Google Scholar
• Oerlemans C, Bult W, Bos M, Storm G, Nijsen JF, Hennink WE. 2010. Polymeric micelles in anticancer therapy: targeting, imaging and triggered release. Pharm Res. 27:2569–2589.
   PubMed Web of Science ®Google Scholar
• Sawyer MB, Pituskin E, Damaraju S, Bies RR, Vos LJ, Prado CM, Kuzma M, Scarfe AG, Clemons M, Tonkin K, et al. 2016. A uridine glucuronosyltransferase 2B7 polymorphism predicts epirubicin clearance and outcomes in early-stage breast cancer. Clin Breast Cancer. 16:139–144.e131–133.
   PubMed Web of Science ®Google Scholar
• Senarathna SM, Page-Sharp M, Crowe A. 2016. The interactions of P-glycoprotein with antimalarial drugs, including substrate affinity, inhibition and regulation. PLoS One. 11:e0152677.
   PubMed Web of Science ®Google Scholar
• Thakral NK, Ray AR, Bar-Shalom D, Eriksson AH, Majumdar DK. 2012. Soluplus-solubilized citrated camptothecin-a potential drug delivery strategy in colon cancer. AAPS PharmSciTech. 13:59–66.
   PubMed Web of Science ®Google Scholar
• Thorn CF, Oshiro C, Marsh S, Hernandez-Boussard T, McLeod H, Klein TE, Altman RB. 2011. Doxorubicin pathways: pharmacodynamics and adverse effects. Pharmacogenet Genomics. 21:440–446.
   PubMed Web of Science ®Google Scholar
• Villunger A, Michalak EM, Coultas L, Mullauer F, Bock G, Ausserlechner MJ, Adams JM, Strasser A. 2003. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science. 302:1036–1038.
   PubMed Web of Science ®Google Scholar
• Wang J, Ma W, Tu P. 2015. Synergistically improved anti-tumor efficacy by co-delivery doxorubicin and curcumin polymeric micelles. Macromol Biosci. 15:1252–1261.
   PubMed Web of Science ®Google Scholar
• Wei Z, Hao J, Yuan S, Li Y, Juan W, Sha X, Fang X. 2009. Paclitaxel-loaded pluronic P123/F127 mixed polymeric micelles: formulation, optimization and in vitro characterization. Int J Pharm. 376:176–185.
   PubMed Web of Science ®Google Scholar
• Xue F, Ling L, Jiang H, Jiang K, Jin Y, Zheng J. 2014. Dihydroartemisinin potentiates the anticancer effect of cisplatin via mTOR inhibition in cisplatin-resistant ovarian cancer cells: involvement of apoptosis and autophagy. Biochem Biophys Res Commun. 444:376–381. DOI:10.1016/j.bbrc.2014.01.053.
   PubMed Web of Science ®Google Scholar
• Xiang T, Cai XB, Zhang Z, Wei R. 2016. In vitro and in vivo inhibition of tumor cell viability by combined dihydroartemisinin and doxorubicin treatment, and the underlying mechanism. Oncol Lett. 12:3701–3706. DOI:10.3892/ol.2016.5187.
   PubMed Web of Science ®Google Scholar
• Yokoyama M. 2011. Clinical applications of polymeric micelle carrier systems in chemotherapy and image diagnosis of solid tumors. J Exp Clin Med. 3:151–158.
   Google Scholar
• Zhang H, Jiang W, Liu R, Zhang J, Zhang D, Li Z, Luan Y. 2017. Rational design of metal organic framework nanocarrier-based codelivery system of doxorubicin hydrochloride/verapamil hydrochloride for overcoming multidrug resistance with efficient targeted cancer therapy. ACS Appl Mater Interfaces. 9:19687–19697.
   PubMed Web of Science ®Google Scholar
• Zhao J, Xu Y, Wang C, Ding Y, Chen M, Wang Y, Peng J, Li L, Lv L. 2017. Soluplus/TPGS mixed micelles for dioscin delivery in cancer therapy. Drug Dev Ind Pharm. 43:1197–1204.
   PubMed Web of Science ®Google Scholar