Production and Characterization of Microbial Carotenoids as an Alternative to Synthetic Colors: a Review

REFERENCES

• Gu , Z. , Chen , D. , Han , Y. , Chen , Z. and Gu , F. 2008 . Optimization of carotenoids extraction from . Rhodobacter sphaeroides. , 41 : 1082 – 1088 . LWT
   Google Scholar
• Bandich , A. and Olson , J.A. 1989 . Biological actions of carotenoids . FASEB Journal , 3 : 1927 – 1932 .
   PubMedGoogle Scholar
• Goodwin , T.W. 1980 . The biochemistry of the carotenoids , Vol. 1 , 257 – 290 . London : Chapman Hall . Plants
   Google Scholar
• Johnson , E.A. and Schroeder , W.A. 1995 . Microbial carotenoids . Advances in Biochemical Engineering and Biotechnology , 53 : 119 – 178 .
   Google Scholar
• Clinton , S.K. 1998 . Lycopene: Chemistry, biology and implications for human health and disease . Nutrition Reviews , 56 : 35 – 51 .
   PubMed Web of Science ®Google Scholar
• Haard , N.F. 1988 . Astaxanthin formation by yeast Phaffia rhodozyma on molasses . Biotechnology Letters , 10 : 609 – 614 .
   Web of Science ®Google Scholar
• Fang , T.J. and Wang , J.M. 2002 . Extractability of Astaxanthin in a mixed culture of a carotenoid over-producing mutant of Xanthophyllomyces dendrorhous and Bacillus circulans in two stage batch fermentation . Process Biochemistry , 27 : 1235 – 1245 .
   Google Scholar
• Buzzini , P. and Martini , A. 2000 . Production of carotenoids by strains of Rhodotorula glutinis cultured in raw materials of agro-industrial origin . Bioresource Technology , 71 : 41 – 44 .
   Web of Science ®Google Scholar
• Zeb , A. and Mehmood , S. 2004 . Carotenoids content from various sources and their potential health applications . Pakistan Journal of Nutrition , 3 : 199 – 204 .
   Google Scholar
• Corol , D. , Dorobantu , I.I. , Toma , N. and Nitu , R. 2002 . Diversity of biological functions of carotenoids . Romanian Biotechnological Letters , 8 ( 1 ) : 1067 – 1074 .
   Google Scholar
• Perera , C.O. and Yen , G.M. 2007 . Functional properties of carotenoids in human health . International Journal of Food Properties , 10 : 201 – 230 .
   Web of Science ®Google Scholar
• Barnett , Y.A. and King , C.M. 1995 . An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in humans . Mutation Research , 338 : 115 – 128 .
   PubMed Web of Science ®Google Scholar
• Bendich , A. 1994 . Recent advances in clinical research involving carotenoids . Pure and Applied Chemistry , 66 : 1017 – 1024 .
   Web of Science ®Google Scholar
• Krinsky , N.I. 2001 . Carotenoids as antioxidants . Nutrition , 17 ( 10 ) : 815 – 817 .
   PubMedGoogle Scholar
• Bendich , A. 1989 . Symposium conclusions: Biological actions of carotenoids . The Journal of Nutrition , 119 ( 1 ) : 135 – 136 .
   PubMedGoogle Scholar
• Halliwell , B. and Gutteridge , J.M.C. Free radicals in biology and medicine , 3rd , New York, NY : Oxford University Press, New York .
   Google Scholar
• Higdon, J. Chlorophyll and chlorophyllin. 2004 http://lpi.oregonstate.edu/infocenter/phytochemicals/chlorophylls/ (http://lpi.oregonstate.edu/infocenter/phytochemicals/chlorophylls/) (Accessed: 17 February 2011 ).
   Google Scholar
• Krinsky , N.I. , Landrum , J.T. and Bone , R.A. 2003 . Biological mechanisms of the protective role of lutein and zeaxanthin in the eye . Annual Review of Nutrition , 23 : 171 – 201 .
   PubMed Web of Science ®Google Scholar
• Krinsky , N.I. 1994 . The biological properties of carotenoids . Pure and Applied Chemistry , 66 ( 6 ) : 1003 – 1010 .
   Google Scholar
• Krinsky , N.I. and Deneke , S.M. 1982 . Interaction of oxygen and oxy-radicals with carotenoids . Journal of the National Cancer Institute , 69 : 205 – 210 .
   PubMed Web of Science ®Google Scholar
• Gerster , H. 1991 . Potential role of Beta-carotene in the prevention of cardiovascular disease . International Journal of Vitamin and Nutrition Research , 61 : 277 – 291 .
   PubMed Web of Science ®Google Scholar
• Sesso , H.D. , Buring , J.E. , Norkus , E.P. and Gaziano , J.M. 2004 . Plasma lycopene, other carotenoids and rentinol and the risk of cardiovascular disease in women . American Journal of Clinical Nutrition , 79 ( 1 ) : 47 – 53 .
   PubMed Web of Science ®Google Scholar
• Rissanen , T.H. , Voutilainen , S. and Nyyssonen , K. 2001 . Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study . British Journal of Nutrition , 85 ( 6 ) : 749 – 754 .
   PubMed Web of Science ®Google Scholar
• Street , D.A. , Comstock , G.W. , Salkeled , R.M. , Schuep , W. and Klag , M.J. 1994 . Serum antioxidants and myocardial infarction . Are low levels of carotenoids and alpha-tocopherol risk factors for myocardial infarction? Circulation , 90 ( 3 ) : 1154 – 1161 .
   Google Scholar
• Sesso , H.D. , Buring , J.E. , Norkus , E.P. and Gaziano , J.M. 2005 . Plasma lycopene, other carotenoids and rentinol and the risk of cardiovascular disease in men . American Journal of Clinical Nutrition , 81 ( 5 ) : 990 – 997 .
   PubMed Web of Science ®Google Scholar
• Hak , A.E. , Stampfer , M.J. and Campos , H. 2003 . Plasma carotenoids and tocopherols and risk of myocardial infarction in a low-risk population of US male physicians . Circulation , 108 ( 7 ) : 802 – 807 .
   PubMed Web of Science ®Google Scholar
• Evans , R.W. , Shaten , B.J. , Day , B.W. and Kuller , L.H. 1998 . Prospective association between lipid soluble antioxidants and coronary heart disease in men . The multiple risk factor intervention trial. American Journal of Epidemiology , 147 ( 2 ) : 180 – 186 .
   Google Scholar
• Sahyoun , N.R. , Jacques , P.F. and Russe , R.M. 1996 . Carotenoids, vitamins C and E, and mortality in an elderly population . American Journal of Epidemiology , 144 ( 5 ) : 501 – 511 .
   PubMedGoogle Scholar
• Bhosale , P. and Gadre , R.V. 2001 . Production of β-carotene by a Rhodotorula glutinis mutant in seawater medium . Bioresource Technology , 76 : 53 – 55 .
   PubMed Web of Science ®Google Scholar
• Bhosale , P. and Gadre , R.V. 2001 . β-carotene production in sugarcane molasses by a Rhodotorula glutinis mutant . Journal of Industrial Microbiology and Biotechnology , 26 : 327 – 332 .
   PubMed Web of Science ®Google Scholar
• Frengova , G. , Simova , E.D. , Pavlova , K. , Beshkova , D.M. and Grigirova , D. 1994 . Formation of carotenoids by Rhodotorula glutinis in whey ultrafilterate . Biotechnology and Bioengineering , 44 : 888 – 894 .
   PubMedGoogle Scholar
• Malisorn , C. and Suntornsuk , W. 2008 . Optimization of β-carotene production by Rhodotorula glutinis DM28 in fermented radish brine . Bioresource Technology , 99 : 2281 – 2287 .
   PubMed Web of Science ®Google Scholar
• Martin , A.M. , Lu , C. and Patel , T.R. 1993 . Growth parameters for Rhodotorula rubra grown in peat extracts . Journal of Fermentation and Bioengineering , 76 : 321 – 325 .
   Google Scholar
• Buzzini , P. 2001 . Batch and fed batch carotenoid production by Rhodotorula glutinis-Debaryomyces castellii co-cultures in corn syrup . Journal of Applied Microbiology , 90 : 843 – 847 .
   PubMed Web of Science ®Google Scholar
• Kvasnikov , E.I. , Grinberg , T.A. , Vaskivnjuk , V.T. , Nagornaja , S.S. , Sudenko , V.I. and Stelokova , I.F. 1978 . Yeasts synthesizing carotenoids Izv . ANSSR Seria Biologicheskaja , 4 : 565 – 575 .
   Google Scholar
• Meyer , P.S. and Du Perez , J.C. 1994 . Astaxanthin production by a Phaffia rhodozyma mutant on grape juice . World Journal of Microbiology and Biotechnology , 10 : 178 – 183 .
   PubMedGoogle Scholar
• Davoli , P. , Mierau , V. and Weber , R.W.S. 2004 . Carotenoids and fatty acids in red yeasts Sporobolomyces roseus and Rhodotorula glutinis . Applied Biochemistry and Microbiology , 40 : 392 – 397 .
   Web of Science ®Google Scholar
• An , G-H. , Cho , M-H. and Johnson . 1999 . EA Monocyclic carotenoids biosynthetic pathway in the yeast Phaffia rohodozyma (Xanthophyllomyces dendrorhous) . Journal of Bioscience and Bioengineering , 88 : 189 – 193 .
   PubMedGoogle Scholar
• Misawa , N. and Shimada , H. 1998 . Metabolic engineering for the production of carotenoids in noncarotenogenic bacteria and yeasts . Journal of Biotechnology , 59 : 169 – 181 .
   Google Scholar
• Dannert , C.S. , Umeno , D. and Arnold , F.H. 2000 . Molecular breeding of carotenoid biosynthetic pathways . Nature Biotechnology , 18 : 750 – 753 .
   PubMedGoogle Scholar
• Armstrong , G.A. and Hearst , J.E. 1986 . Carotenoids 2. Genetics and molecular biology of carotenoid pigment biosynthesis . FASEB Journal , 10 : 228 – 237 .
   Google Scholar
• Sandmann , G. 1994 . Carotenoid biosynthesis in microorganisms and plants . European Journal of Biochemistry , 223 : 7 – 24 .
   PubMedGoogle Scholar
• Cunningham , F.X. Jr , Chamovitz , D and Misawa , N. 1993 . Gantt, E.; Hirschberg, J. Cloning and functional expression in Escherichia coli of a cyanobacterial gene for lycopene cyclase, the enzyme that catalyzes the biosynthesis of β-carotene . FEBS Letters , 328 : 130 – 138 .
   PubMedGoogle Scholar
• Shih , C.T. and Hang , Y.D. 1996 . Production of carotenoids by Rhodotorula rubra from sauerkraut brine . Lebensm.-Wiss. U.-Technology , 29 : 570 – 572 .
   Google Scholar
• Aksu , Z. and Eren , A.T. 2005 . Carotenoids production by the yeast Rhodotorula mucilaginosa, Use of agricultural wastes as a carbon source . Process Biochemistry , 40 : 2985 – 2991 .
   Web of Science ®Google Scholar
• Somashekar , D. and Joseph , R. 2000 . Inverse relationship between carotenoid and lipid formation in Rhodotorula glutinis according to the C/N ratio of the growth medium . World Journal of Microbiology and Technology , 16 : 491 – 493 .
   Web of Science ®Google Scholar
• Park , P.K. , Cho , D.H. , Kim , E.Y. and Chu , K.H. 2005 . Optimization of carotenoid production by Rhodotorula glutinis using statistical experimental design . World Journal of Microbiology and Biotechnology , 21 : 429 – 434 .
   Web of Science ®Google Scholar
• Simova , E.D. , Frengova , G.I. and Beshkova , D.M. 2003 . Effect of aeration on the production of carotenoid pigments by Rhodotorula rubra-lacobacillus casei subsp casei co-cultures in whey ultrafilterate . Z Naturforsch , 58c : 225 – 229 .
   Google Scholar
• Buzzini , P. , Martini , A. , Gaetani , M. , Turchetti , B. , Pagnoni , U.M. and Davoli , P. 2005 . Optimization of carotenoid production by Rhodotorula graminis DBVPG 7021 as a function of trace element concentration by means of response surface analysis . Enzyme and Microbial Technology , 36 : 687 – 692 .
   Google Scholar
• Komemushi , S. , Sakai , H. , Yokoyama , A. and Fujita , T. 1994 . Effect of barium and other metals on the growth of a D-lactic assimilating yeast Rhodotorula glutinis no. 21 . Journal of Antibacterial and Antifungal Agents , 22 : 583 – 587 .
   Google Scholar
• Chen , D. , Han , Y. and Gu , Z. 2006 . Application of statistical methodology to the optimization of fermentative medium for carotenoids production by Rhodobacter sphaeroides . Process Biochemistry , 41 : 1773 – 1778 .
   Web of Science ®Google Scholar
• Kim , S.W. , Seo , W.T. and Park , Y.H. 1997 . Enhanced synthesis of trisporic acid and β-carotene production in Blakeslea trispora by addition of a non-ionic surfactant, Span 20 . Journal of Fermentation Bioengineering , 84 : 330 – 332 .
   Google Scholar
• Simpson , K.L. , Chichester , C.O. and Phaff , H.J. 1977 . “ Carotenoid pigments of yeasts ” . In The yeasts , Edited by: Rose , A.H. and Harrison , J.S. Vol. 2 , 493 – 515 . New York : Academic Press .
   Google Scholar
• Weber , R.W.S. , Anke , H. and Davoli , P. 2007 . Simple method for the extraction and reversed-phase high-performance liquid chromatographic analysis of carotenoid pigments from red yeasts (Basidiomycota, Fungi) . Journal of Chromatography A , 1145 : 118 – 122 .
   PubMed Web of Science ®Google Scholar
• Breitenbach , J. , Braun , G. , Steiger , S. and Sandmann , G. 2001 . Chromatographic performance on a C30-bonded stationary phase of monohydroxycarotenoids with variable chain length or degree of desaturation and of lycopene isomers synthesized by various carotene desaturases . Journal of Chromatography A , 936 : 56 – 69 .
   Google Scholar
• Andrews , B.A. and Asenjo , J.A. 1987 . Enzymatic lysis and disruption of microbial cells . Trends in Biotechnology , 5 : 273 – 277 .
   Web of Science ®Google Scholar
• Kaiser , P. , Surmann , P. , Vallentin , G. and Fuhrmann , H. 2007 . A small scale method for quantitation of carotenoids in bacteria and yeasts . Journal of Microbiological Methods , 70 : 142 – 149 .
   PubMed Web of Science ®Google Scholar
• Ferrer , P. 2006 . Revisiting the cellulosimicrobium cellulans yeast–lytic β-1,3-glucanases toolbox, a review . Microbial Cell Factories , 5 : 1 – 24 .
   PubMedGoogle Scholar
• Adamitsch , B.F. , Karner , F. and Hampel , W. 2003 . Proteolytic activity of a yeast cell wall lytic Arthrbacter species . Letters in Applied Microbiology , 36 : 227 – 229 .
   PubMed Web of Science ®Google Scholar
• Davoli , P. and Weber , R.W.S. 2002 . Carotenoid pigments from red mirror yeast Sporobolomyces roseus . Mycologist , 16 : 103 – 110 .
   Google Scholar
• Johnson , E.A. and An , G.H. 1991 . Astaxanthin from microbial sources . Critical reviews in Biotechnology , 11 : 297 – 326 .
   Web of Science ®Google Scholar
• Oliver , J. and Palou , A. 2000 . Chromatographic determination of carotenoids in foods . Journal of Chromatography A , 881 : 543 – 555 .
   PubMed Web of Science ®Google Scholar
• Lacker , T. , Strohschein , S. and Albert , K. 1999 . Separation and identification of various compounds by C 30 reversed phase-high performance liquid chromatography coupled to UV and atmospheric pressure chemical ionization mass spectrometric detection . Journal of Chromatography A , 854 : 37 – 44 .
   PubMed Web of Science ®Google Scholar
• Hodisan , T. , Socaciu , C. , Ropan , I. and Neamtu , G. 1997 . Carotenoid composition of Rosa canina fruits determined by thin layer chromatography and high performance liquid chromatography . Journal of Pharmaceutical and Biomedical Analysis , 16 : 521 – 528 .
   PubMed Web of Science ®Google Scholar
• Britton , G. 1998 . Carotenoids, biosynthesis and metabolism , Vol. 3 , 148 – 194 . Basel : Birkhauser Verlag .
   Google Scholar
• Weber , R.W.S. , Madhour , A. , Anke , H. , Adele , M. and Davoli , P. 2005 . 2-Hydroxytorularhodin, a new xanthophylls from the red yeast Sporobolomyces coprosmae . Helvetica Chimica Acta , 88 : 2960 – 2966 .
   Web of Science ®Google Scholar
• Grung , M. , D'Souza , F.M.L. , Borowitzka , M. and Liaeen-Jensen , S. 1992 . Algal carotenoids 51. Secondary carotenoids,2.Haematococcus pluvialis aplanospores as a source of (3S, 3'S)- astaxanthin esters . Journal of Applied Phycology , 4 : 165 – 171 .
   Google Scholar
• Yuan , J.P. and Chen , F. 1998 . Chromatographic separation and purification of trans-astaxanthin from the extracts of Haematococcus pluvialis . Journal of Agricultural Food Chemistry , 46 : 3371 – 3375 .
   Web of Science ®Google Scholar
• Nelis , H.J. and De Leenheer , A.P. 1989 . “ Microbial production of carotenoids other than β-carotene. In: Vandamme. E.J ” . In Biochemistry of vitamins, pigments and growth factors , 43 – 80 . London, NY : Elsevier Applied Science .
   Google Scholar
• Yokoyama , A. and Miki , W. 1995 . Composition and presumed biosynthetic pathway of carotenoids in the Astaxanthin-producing bacterium Agrobacterium aurantiacum . FEMS Microbiology Letters , 128 : 139 – 144 .
   Google Scholar
• Andrews , A.G. , Phaff , H.J. and Starr , M.P. 1976 . Carotenoids of Phaffia rhodozyma, a red pigmented fermenting yeast . Phytochemistry , 15 : 1003 – 1007 .
   Google Scholar
• Parajo , J.C. , Santos , V. and Vazquez , M. 1998 . Productionof carotenoids by Phaffia rhodozyma growing on media made from hemicellulosic hydrolysates of Eucalyptius globules wood . Biotechnology and Bioengineering , 59 : 501 – 506 .
   PubMed Web of Science ®Google Scholar
• Tinoi , J. , Rakariyatham , N. and Deming , R.L. 2006 . Utilization of mustard waste isolates for improved production of Astaxanthin by Xanthophyllomyces dendrorhous . Journal of Industrial Microbiology and Biotechnology , 33 : 309 – 314 .
   PubMed Web of Science ®Google Scholar
• Ramirez , J. , Nunez , M.L. and Valdivia , R. 2000 . Increased Astaxanthin production by a Phaffia rhodozyma mutant grown on date juice from Yucca fillifera . Journal of Industrial Microbiology and Biotechnology , 24 : 187 – 190 .
   Web of Science ®Google Scholar
• Orosa , M. , Valero , J.F. , Herrero , C. and Abalde , J. 2001 . Comparison of the accumulation of astaxanthin in Haematococcus pluvialis and other green microalgae under N-starvation and high light conditions . Biotechnology Letters , 23 : 1079 – 1085 .
   Web of Science ®Google Scholar
• Schroeder , W.A. and Johnson , E.A. 1995 . Carotenoids protect Phaffia Rhodozyma against singlet oxygen damage . Journal of Industrial Microbiology , 14 : 502 – 507 .
   Google Scholar
• Schroeder , W.A. and Johnson , E.A. 1993 . Antioxidant role of carotenoids in Phaffia Rhodozyma . Journal of General Microbiology , 139 : 907 – 912 .
   Google Scholar
• Sakaki , H. , Nakanishi , T. , Satonaka , K-Y. , Miki , W. , Fujita , T. and Komemushi , S. 2000 . Properties of a high-torularhodin-producing mutant of Rhodotorula glutinis cultivated under oxidative stress . Journal of Bioscience Bioengineering , 89 : 203 – 205 .
   PubMed Web of Science ®Google Scholar
• Madhour , A. , Anke , H. , Mucci , A. , Davoli , P. and Weber , R.W.S. 2005 . Biosynthesis of xanthophylls plectaniaxanthin as a stress response in the red yeast Dioszegia (Ttremellales, Heterobasidiomycetes, Fungi) . Phytochemistry , 66 : 2617 – 2626 .
   PubMed Web of Science ®Google Scholar
• Marusich , W.L. and Bauerfeind , J.C. 1981 . “ Oxycarotenoids in poultry feed. In: Bauerfeind, J.C ” . In Carotenoids as colorants and retinol precursors , 320 – 462 . New York : Academic Press .
   Google Scholar
• 2000 . Naguib Antioxidant activities of Astaxanthin and related carotenoids . Journal of Agricultural Chemistry , 48 : 1150 – 1154 .
   PubMed Web of Science ®Google Scholar
• Lorenz , R.T. Method for retarding and preventing sunburn by UV light . U.S. Patent, 6433025 . 2002 .
   Google Scholar
• Moller , A.P. , Biard , C. , Blount , J.D. , Houston , D.C. , Ninni , P. , Saino , N. and Surai , P.F. 2000 . Carotenoid-dependent signals indicators of foraging efficiency, immunocompetence or detoxification ability? . Avian Poultry Biology Reviews , 11 : 137 – 159 .
   Google Scholar
• Nelis , H.J. and De Leenheer , A.P. 1991 . A review, microbial sources of carotenoid pigments used in foods and feeds . Journal of Applied Bacteriology , 70 : 181 – 191 .
   Google Scholar
• Asker , D. and Ohta , Y. 2002 . Production of canthaxanthin by Haloferax alexandrinus under non-aseptic conditions and a simple, rapid method for its extraction . Applied Microbiology and Biotechnology , 58 : 743 – 750 .
   PubMedGoogle Scholar
• Di Mascio , P. , Murphy , M.E. and Sies , H. 1991 . Antioxidant defense systems, the role of carotenoids, tocopherols and thiols . American Journal of Clinical Nutrition , 53 : 194S – 200S .
   PubMed Web of Science ®Google Scholar
• Hsu , W.J. , Yokoyama , H. and DeBenedict , C. 1990 . Chemical bioregulation of carotenogenesis in Phycomyces blakesleeanus . Phytochemistry , 29 : 2447 – 2451 .
   Google Scholar
• Feofilova , E.P. , Tereshina , V.M. and Memorskaya , A.S. 1995 . Regulation of lycopene biosyntheseis in mucurous fungus Blakeslea trispora by pyridine derivatives . Mikrobiologiya , 64 : 734 – 740 .
   Google Scholar
• Feofilova , E.P. , Tereshina , V.M. , Memorskaya , A.S. , Dul'kin , L.M. and Goncharov , N.G. 2006 . Fungal lycopene, the biotechnology of its production and prospects for its application in medicine . Microbiology , 75 : 629 – 633 .
   Google Scholar
• Anon . 1997 . A summary of the Application for the Evaluation of Lyc-O-Mato lycopene oleoresin from tomatoes under European Regulation (EC) No. 258/97 for extension of food use ,
   Google Scholar
• Finkelstein , M. , Huang , C.C. , Byng , G.S. , Tsau , B.R. and Leach , J. Methods for producing beta-carotene using a fungal malted culture . Patent PCT/US93/02305 . 1993 .
   Google Scholar
• Duffose , L. , Galaup , P. , Yaron , A. , Arad , S.M. , Blanc , P. , Murthy , K.N.C. and Ravishankar , G.A. 2005 . Microorganisms and microalgae as sources of pigments for food use: a scientific oddity or an industrial reality? . Trends in Food Science and Technology , 16 : 389 – 406 .
   Google Scholar
• Tornwall , M.E. , Virtamo , J. , Korhonen , P.A. , Virtanen , M.J. , Taylor , P.R. Albanes , D. 2004 . Effect of alpha-tocopherol and β-carotene supplementation on coronary heart disease during the 6-year post-trial follow–up in the ATBC study . European Heart Journal , 25 : 1171 – 1178 .
   PubMed Web of Science ®Google Scholar
• Cantrell , A. , McGarvey , D.J. , Trustcott , G. , Rancon , F. and Bohmm , F. 2003 . Singlet oxygen quenching by dietary carotenoids in a model membrane environment . Archives of Biochemistry and Biophysics , 412 : 47 – 54 .
   PubMed Web of Science ®Google Scholar
• Dufosse , L. 2006 . Microbial production of food grade pigments . Food Technology and Biotechnology , 44 ( 3 ) : 313 – 321 .
   Web of Science ®Google Scholar