3,164
Views
26
CrossRef citations to date
0
Altmetric
Original Article

Anticholinergic and antidiabetic effects of isoeugenol from clove (Eugenia caryophylata) oil

Pages 583-592 | Received 22 Dec 2018, Accepted 15 Mar 2019, Published online: 02 Apr 2019

References

  • Gulcin, I.; Şat, İ. G.; Beydemir, Ş.; Elmastaş, M.; Küfrevioğlu, Ö. İ. Comparison of Antioxidant Activity of Clove (Eugenia caryophylata Thunb) Buds and Lavender (Lavandula Stoechas L.). Food. Chem. 2004, 87, 393–400. DOI: 10.1016/j.foodchem.2003.12.008.
  • Lee, K. G.; Shibamoto, T. Antioxidant Property of Aroma Extract Isolated from Clove Buds [Syzygium aromaticum (L.) Merr. Et Perry]. Food. Chem. 2002, 74, 443–448. DOI: 10.1016/S0308-8146(01)00161-3.
  • Gulcin, I.; Elmastaş, M.; Aboul-Enein, H. Y. Antioxidant Activity of Clove Oil: A Powerful Antioxidant Source. Arab. J. Chem. 2012, 5(4), 489–499. DOI: 10.1016/j.arabjc.2010.09.016.
  • Liang-Liang, Z.; Li-Fang, Z.; Jian-Guo, X.; Qing-Ping, H. Comparison Study on Antioxidant, DNA Damage Protective and Antibacterial Activities of Eugenol and Isoeugenol against Several Foodborne Pathogens. Food Nutr. Res. 2017, 61(1), 1353356. DOI: 10.1080/16546628.2017.1339555.
  • Atsumi, T.; Fujisawa, S.; Tonosaki, K. A Comparative Study of the Antioxidant/Prooxidant Activities of Eugenol and Isoeugenol with Various Concentrations and Oxidation Conditions. Toxicol. In. Vitro. 2005, 19, 1025–1033. DOI: 10.1016/j.tiv.2005.04.012.
  • Gulcin, I. Antioxidant Activity of Eugenol: A Structure and Activity Relationship Study. J. Med. Food. 2011, 14(9), 975–985. DOI: 10.1089/jmf.2010.0197.
  • Koksal, E.; Bursal, E.; Gulcin, I.; Korkmaz, M.; Çağlayan, C.; Goren, A. C.; Alwasel, S. H. Antioxidant Activity and Polyphenol Content of Turkish Thyme (Thymus vulgaris) Monitored by LC-MS/MS. Int. J. Food Propert. 2017, 20(3), 514–525. DOI: 10.1080/10942912.2016.1168438.
  • Gulcin, I.; Beydemir, Ş.; Alici, H. A.; Elmastaş, M.; Büyükokuroğlu, M. E. In vitro Antioxidant Properties of Morphine. Pharmacol. Res. 2004, 49, 59–66.
  • Gülçin, İ.; Şat, İ. G.; Beydemir, Ş.; Küfrevioğlu, Ö. İ. Evaluation of the In Vitro Antioxidant Properties of Extracts of Broccoli (Brassica oleracea L.). Ital. J. Food Sci. 2004, 16, 17–30.
  • Oztaskin, N.; ÇEtinkaya, Y.; Taslimi, P.; Göksu, S.; Gulcin, I. Antioxidant and Acetylcholinesterase Inhibition Properties of Novel Bromophenol Derivatives. Bioorg. Chem. 2015, 60, 49–57. DOI: 10.1016/j.bioorg.2015.04.006.
  • Gulcin, I.; Elias, R.; Gepdiremen, A.; Taoubi, K.; Köksal, E. Antioxidant Secoiridoids from Fringe Tree (Chionanthus Virginicus L.). Wood Sci. Technol. 2009, 43(3–4), 195–212. DOI: 10.1007/s00226-008-0234-1.
  • Gulcin, I.; Küfrevioğlu, Ö. İ.; Oktay, M.; Büyükokuroğlu, M. E. Antioxidant, Antimicrobial, Antiulcer and Analgesic Activities of Nettle (Urtica dioica L.). J. Ethnopharmacol. 2004, 90, 205–215. DOI: 10.1016/j.jep.2003.09.028.
  • Bulut, N.; Koçyiğit, U. M.; Gecibesler, I. H.; Dastan, T.; Karci, H.; Taslimi, P.; Durna Dastan, S.; Gulcin, I. Cetin, A. Synthesis of Some Novel Pyridine Compounds Containing Bis-1,2,4-Triazole Moiety and Investigation of Their Antioxidant Properties, Carbonic Anhydrase and Acetylcholinesterase Enzymes Inhibition Profiles. J. Biochem. Mol. Toxicol. 2018, 32(1), e22006. DOI: 10.1002/jbt.22006.
  • Turan, B.; Sendil, K.; Sengul, E.; Gultekin, M. S.; Taslimi, P.; Gulcin, I.; Supuran, C. T. The Synthesis of Some β-lactams and Investigation of Their Metal Chelating Activity, Carbonic Anhydrase and Achetylcholinesterase Inhibition Profiles. J. Enzyme Inhib. Med. Chem. 2016, 31(S1), 79–88. DOI: 10.3109/14756366.2016.1170014.
  • Özbey, F.; Taslimi, P.; Gulcin, I.; Maraş, A.; Goksu, S.; Supuran, C. T. Synthesis, Acetylcholinesterase, Butyrilcholinesterase, Carbonic Anhydrase Inhibitory and Metal Chelating Properties of Some Novel Diaryl Ether. J. Enzyme Inhib. Med. Chem. 2016, 31(S2), 79–85. DOI: 10.1080/14756366.2016.1189422.
  • Garibov, E.; Taslimi, P.; Sujayev, A.; Bingöl, Z.; Çetinkaya, S.; Gulcin, I.; Beydemir, S.; Farzaliyev, V.; Alwasel, S. H.; Supuran, C. T. Synthesis of 4,5-Disubstituted-2-Thioxo-1,2,3,4-Tetrahydropyrimidines and Investigation of Their Acetylcholinesterase, Butyrylcholinesterase, Carbonicanhydrase I/II Inhibitory and Antioxidant Activities. J. Enzyme Inhib. Med. Chem. 2016, 31(S3), 1–9. DOI: 10.1080/14756366.2016.1198901.
  • Aksu, K.; ÖZgeriş, B.; Taslimi, P.; Naderi, A.; Gulcin, I.; Göksu, S. Antioxidant Activity, Acetylcholinesterase and Carbonic Anhydrase Inhibitory Properties of Novel Ureas Derived from Phenethylamines. Arch. Pharm. 2016, 349(12), 944–954. DOI: 10.1002/ardp.201600183.
  • Taslimi, P.; Sujayev, A.; Mamedova, S.; Kalın, P.; Gulcin, I.; Sadeghian, N.; Beydemir, S.; Küfrevioglu, Ö. İ.; Alwasel, S. H.; Farzaliyev, V.; et al. Synthesis and Bioactivity of Several New Hetaryl Sulfonamides. J. Enzyme Inhib. Med. Chem. 2017, 32(1), 137–145. DOI: 10.1080/14756366.2016.1238367.
  • Bayrak, Ç.; Taslimi, P.; Gulcin, I.; Menzek, A. The First Synthesis of 4-Phenylbutenone Derivative Bromophenols Including Natural Products and Their Inhibition Profiles for Carbonic Anhydrase, Acetylcholinesterase and Butyrylcholinesterase Enzymes. Bioorg. Chem. 2017, 72, 359–366. DOI: 10.1016/j.bioorg.2017.03.001.
  • Aktaş, A.; Taslimi, P.; Gulcin, I.; GöK, Y. Novel NHC Precursors: Synthesis, Characterization and Carbonic Anhydrase and Acetylcholinesterase Inhibitory Properties. Arch. Pharm. 2017, 350(6), e1700045. DOI: 10.1002/ardp.201700045.
  • Zengin, M.; Genc, H.; Taslimi, P.; Kestane, A.; Guclu, E.; Ogutlu, A.; Karabay, O.; Gulcin, I. Novel Thymol Bearing Oxypropanolamine Derivatives as Potent Some Metabolic Enzyme inhibitors-Their Antidiabetic, Anticholinergic and Antibacterial Potentials. Bioorg. Chem. 2018, 81, 119–126. DOI: 10.1016/j.bioorg.2018.08.003.
  • Huseynova, M.; Taslimi, P.; Medjidov, A.; Farzaliyev, V.; Aliyeva, M.; Gondolova, G.; Şahin, O.; Yalçın, B.; Sujayev, A.; Orman, E. B.; et al. Synthesis, Characterization, Crystal Structure, Electrochemical Studies and Biological Evaluation of Metal Complexes with Thiosemicarbazone of Glyoxylic Acid. Polyhedron. 2018, 155, 25–33. DOI: 10.1016/j.poly.2018.08.026.
  • Turkan, F.; Cetin, A.; Taslimi, P.; Gulcin, I.; Some Pyrazoles Derivatives: Potent Carbonic Anhydrase, α-glycosidase and Cholinesterase Enzymes Inhibitors. Arch. Pharm. 2018, 351(10), e1800200. DOI: 10.1002/ardp.201800200.
  • Biçer, A.; Taslimi, P.; Yakali, G.; Gulcin, I.; Gültekin, M. S.; Turgut Cin, G. Synthesis, Characterization, Crystal Structure of Novel Bis-Thiomethylcyclohexanone Derivatives and Their Inhibitory Properties against Some Metabolic Enzymes. Bioorg. Chem. 2019, 82, 393–404. DOI: 10.1016/j.bioorg.2018.11.001.
  • Huseynova, M.; Medjidov, A.; Taslimi, P.; Aliyeva, M. Synthesis, Characterization, Crystal Structure of the Coordination Polymer Zn(II) with Thiosemicarbazone of Glyoxalic Acid and Their Inhibitory Properties against Some Metabolic Enzymes. Bioorg. Chem. 2019, 83, 55–62. DOI: 10.1016/j.bioorg.2018.10.012.
  • Türker, F.; Barut Celepci, D.; Aktaş, A.; Taslimi, P.; Gök, Y.; Aygün, M.; Gulcin, I.; Meta-Cyanobenzyl Substituted Benzimidazole: Synthesis, Characterization, Crystal Structure and Carbonic Anhydrase, α-glycosidase, Butyrylcholinesterase, Acetylcholinesterase Inhibitory Properties. Arch. Pharm. 2018, 351(7), e201800029. DOI: 10.1002/ardp.201800029.
  • Taslimi, P.; Çağlayan, C.; Farzaliyev, F.; Nabiyev, O.; Sujayev, A.; Türkan, F.; Kaya, R.; Gulcin, I.; Synthesis and Discovery of Potent Carbonic Anhydrase, Acetylcholinesterase, Butyrylcholinesterase and α- Glycosidase Enzymes Inhibitors: The Novel N,N′-bis-cyanomethylamine and Alkoxymethylamine Derivatives. J. Biochem. Mol. Toxicol. 2018, 32(4), e22042. DOI: 10.1002/jbt.22042.
  • Xiao, Z.; Storms, R.; Tsang, A. A Quantitative Starch-Iodine Method for Measuring Alpha-Amylase and Glucoamylase Activities. Anal. Biochem. 2006, 351, 146–148. DOI: 10.1016/j.ab.2006.01.036.
  • Taslimi, P.; Gulcin, I. Antidiabetic Potential: In Vitro Inhibition Effects of Some Natural Phenolic Compounds on α-glycosidase and α-amylase Enzymes. J. Biochem. Mol. Toxicol. 2017, 31(10), e21956. DOI: 10.1002/jbt.2017.31.issue-10.
  • Ellman, G. L.; Courtney, K. D.; Andres, V.; Featherston, R. M. A New and Rapid Colorimetric Determination of Acetylcholinesterase Activity. Biochem. Pharmacol. 1961, 7, 88–95.
  • Taslimi, P.; Sujayev, A.; Garibov, E.; Nazarov, N.; Huyut, Z.; Alwasel, S. H.; Gulcin, I. The Synthesis of New Cyclic Thioureas and Evaluation of Their Metal-Chelating Activity, Acetylcholinesterase, Butyrylcholinesterase and Carbonic Anhydrase Inhibition Profiles. J. Biochem. Mol. Toxicol. 2017, 31(7), e21897. DOI: 10.1002/jbt.21897.
  • Öztaşkın, N.; Taslimi, P.; Maras, A.; Göksu, S.; Gulcin, I. Novel Antioxidant Bromophenols with Acetylcholinesterase, Butyrylcholinesterase and Carbonic Anhydrase Inhibitory Actions. Bioorg. Chem. 2017, 74, 104–114. DOI: 10.1016/j.bioorg.2017.07.010.
  • Gulcin, I.; Mshvildadze, V.; Gepdiremen, A.; Elias, R. Antioxidant Activity of Saponins Isolated from Ivy: α-Hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F. Planta. Med. 2004, 70, 561–563.
  • Gulçin, İ.; Taslimi, P.; Aygün, A.; Sadeghian, N.; Bastem, E.; Kufrevioglu, O. I.; Turkan, F.; Şen, F. Antidiabetic and Antiparasitic Potentials: Inhibition Effects of Some Natural Antioxidant Compounds on α-glycosidase, α-amylase and Human Glutathione S-Transferase Enzymes. Int. J. Biol. Macromol. 2018, 119, 741–746. DOI: 10.1016/j.ijbiomac.2018.08.001.
  • Gülçin, İ.; Beydemir, S.; Sat, İ. G.; Küfrevioğlu, Ö. İ. Evaluation of Antioxidant Activity of Cornelian Cherry (Cornus mas L.). Acta. Aliment. 2005, 34(2), 193–202. DOI: 10.1556/AAlim.34.2005.2.13.
  • Elmastaş, M.; Gulcin, I.; Öztürk, L.; Gökçe, İ. Investigation of Antioxidant Properties of Spearmint (Mentha spicata L.). Asian J. Chem. 2005, 17(1), 137–148.
  • Daryadel, S.; Atmaca, U.; Taslimi, P.; Gulcin, I.; Çelik, M. Novel Sulfamate Derivatives of Menthol: Synthesis, Characterization and Cholinesterases and Carbonic Anhydrase Enzymes Inhibition Properties. Arch. Pharm. 2018, 351(11), e1800209. DOI: 10.1002/ardp.201800209.
  • Demir, Y.; Taslimi, P.; Ozaslan, M. S.; Oztaskın, N.; Çetinkaya, Y.; Gulcin, I.;Beydemir, Ş.; Göksu, S. Antidiabetic Potential: In Vitro Inhibition Effects of Bromophenol and Diarylmethanones Derivatives on Metabolic Enzymes. Arch. Pharm. 2018, 351(12), e1800263. DOI: 10.1002/ardp.201800263.
  • Boztaş, M.; Çetinkaya, Y.; Topal, M.; Gulcin, I.; Menzek, A.; Şahin, E.; Tanc, M.; Supuran, C. T. Synthesis and Carbonic Anhydrase Isoenzymes I, II, IX, and XII Inhibitory Effects of Dimethoxy-Bromophenol Derivatives Incorporating Cyclopropane Moieties. J. Med. Chem. 2015, 58(2), 640–650. DOI: 10.1021/jm501573b.
  • Göçer, H.; Akıncıoğlu, A.; Göksu, S.; Gulcin, I.; Supuran, C. T. Carbonic Anhydrase and Acetylcholine Esterase Inhibitory Effects of Carbamates and Sulfamoylcarbamates. J. Enzyme Inhib. Med. Chem. 2015, 30(2), 316–320. DOI: 10.3109/14756366.2014.928704.
  • Gulcin, I.; Alici, H. A.; Cesur, M. Determination of in Vitro Antioxidant and Radical Scavenging Activities of Propofol. Chem. Pharm. Bull. 2005, 53(3), 281–285.
  • Topal, M.; Gocer, H.; Topal, F.; Kalin, P.; Polat Köse, P.; Gülçin, İ.; Çakmak, K. C.; Küçük, M.; Durmaz, L.; Gören, A. C.; et al. Antioxidant, Antiradical and Anticholinergic Properties of Cynarin Purified from the Illyrian Thistle (Onopordum illyricum L.). J. Enzyme Inhib. Med. Chem. 2016, 31(2), 266–275. DOI: 10.3109/14756366.2015.1018244.
  • Taslimi, P.; Aslan, H. E.; Demir, Y.; Oztaskin, N.; Maraş, A.; Gulçin, İ.; Beydemir, S.; Goksu, S. Diarilmethanon, Bromophenols and Diarilmetan Compounds: Discovery of Potent Aldose Reductase, α-Amylase and α-Glycosidase Inhibitors as New Therapeutic Approach in Diabetes and Functional Hyperglycemia. Int. J. Biol. Macromol. 2018, 119, 857–863. DOI: 10.1016/j.ijbiomac.2018.08.004.
  • Akıncıoğlu, A.; Topal, M.; Gülçin, İ.; Göksu, S. Novel Sulfamides and Sulfonamides Incorporating Tetralin Scaffold as Carbonic Anhydrase and Acetylcholine Esterase Inhibitors. Arch. Pharm. 2014, 347(1), 68–76. DOI: 10.1002/ardp.201300273.
  • Murray, A. P.; Faraoni, M. B.; Castro, M. J.; Alza, N. P.; Cavallaro, V. Natural AChE Inhibitors from Plants and Their Contribution to Alzheimer’s Disease Therapy. Curr. Neuropharmacol. 2013, 11(4), 388–413. DOI: 10.2174/1570159X11311040004.
  • Şişecioğlu, M.; Gülçin, İ.; Çankaya, M.; Özdemir, H. The Inhibitory Effects of L-Adrenaline on Lactoperoxidase Enzyme (LPO) Purified from Buffalo Milk. Int. J. Food Propert. 2012, 15(6), 1190–1199. DOI: 10.1080/10942912.2010.511924.
  • Aydin, B.; Gülcin, I.; Alwasel, S. H. Purification and Characterization of Polyphenol Oxidase from Hemşin Apple (Malus communis L.). Int. J. Food Propert. 2015, 18(12), 2735–2745. DOI: 10.1080/10942912.2015.1012725.
  • Altay, A.; Koktepe, T.; Durmaz, L.; Topal, F.; Gülçin, İ.; Koksal, E. Purification and Selected Biochemical Properties of Peroxidase from Cress (Lepidium sativum Sub Sp. Sativum). Int. J. Food Propert. 2018, 21(1), 2610–2621. DOI: 10.1080/10942912.2018.1540989.
  • Altın, S.; Tohma, H.; Gülçin, İ.; Köksal, E. Purification, Characterization and Inhibition Sensitivity of Peroxidase from Wheat (Triticum aestivum Ssp. Vulgare). Int. J. Food Propert. 2017, 20(09), 1949–1959. DOI: 10.1080/10942912.2016.1225308.
  • Köktepe, T.; Altın, S.; Tohma, H.; Gulcin, I.; Koksal, E. Purification, Characterization and Some Inhibition Properties of Peroxidase from Haricot Bean (Phaseolus vulgaris L.). Int. J. Food. Propert. 2017, 20(S2), S1944–S1953.
  • Köksal, Z.; Kalın, R.; Gulcin, I.; Özdemir, H. Inhibitory Effects of Selected Pesticides on Peroxidases Purified by Affinity Chromatography. Int. J. Food Propert. 2018, 21(1), 385–394. DOI: 10.1080/10942912.2018.1424197.
  • Koksal, Z.; Kalın, R.; Gülçin, İ.; Özdemir, H.; Atasever, A. The Impact of Some Avermectins on Lactoperoxidase from Bovine Milk. Int. J. Food. Propert. 2016, 19(6), 1207–1216. DOI: 10.1080/10942912.2015.1076457.
  • Gocer, H.; Topal, F.; Topal, M.; Küçük, M.; Teke, D.; Gülçin, İ.; Alwasel, S. H.; Supuran, C. T. Acetylcholinesterase and Carbonic Anhydrase Isoenzymes I and II Inhibition Profiles of Taxifolin. J. Enzyme Inhib. Med. Chem. 2016, 31(3), 441–447. DOI: 10.3109/14756366.2015.1036051.
  • Taslimi, P.; Osmanova, S.; Gulcin, I.; Sardarova, S.; Farzaliyev, V.; Sujayev, A.; Kaya, R.; Koc, F.; Beydemir, S.; Alwasel, S. H.; et al. Discovery of Potent Carbonic Anhydrase, Acetylcholinesterase and Butyrylcholinesterase Enzymes Inhibitors: The New Amides and Thiazolidineones Synthesized on an Acetophenone Base. J. Biochem. Mol. Toxicol. 2017, 31(9), e21931. DOI: 10.1002/jbt.21931.
  • Taslimi, P.; Akıncıoğlu, H.; Gulcin, I.; Synephrine and phenylephrine act as α-amylase, α-glycosidase, acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase enzymes inhibitors. J. Biochem. Mol. Toxicol. 2017, 31(11), e21973. DOI: 10.1002/jbt.21973.
  • Taslimi, P.; Caglayan, C.; Gulcin, I. The Impact of Some Natural Phenolic Compounds on Carbonic Anhydrase, Acetylcholinesterase, Butyrylcholinesterase, and α-Glycosidase Enzymes: An Antidiabetic, Anticholinergic, and Antiepileptic Study. J. Biochem. Mol. Toxicol. 2017, 31(12), e21995. DOI: 10.1002/jbt.21995.
  • Burmaoglu, S.; Yilmaz, A. O.; Taslimi, P.; Algul, O.; Kılıç, D.; Gulcin, I.; Synthesis and Biological Evaluation of Phloroglucinol Derivatives Possessing α-Glycosidase, Acetylcholinesterase, Butyrylcholinesterase, Carbonic Anhydrase Inhibitory Activity. Arch. Pharm. 2018, 351(2), e1700314. DOI: 10.1002/ardp.201700314.
  • Yamali, C.; Gül, H. İ.; Ece, A.; Taslimi, P.; Gulcin, I.;Synthesis, Molecular Modeling and Biological Evaluation of 4-(5-Aryl-3-(Thiophen-2-Yl)-4,5-Dihydro-1h-Pyrazol-1-Yl)Benzenesulfonamides Towards Acetylcholinesterase, Carbonic Anhydrase I and II Enzymes. Chem. Biol. Drug Des. 2018, 91(4), 854–866. DOI: 10.1111/cbdd.13149.
  • Taslimi, P.; GulçIn, İ. Antioxidant and Anticholinergic Properties of Olivetol. J. Food Biochem. 2018, 42(3), e12516. DOI: 10.1111/jfbc.2018.42.issue-3.
  • Gulcin, I.; Taslimi, P. Sulfonamide Inhibitors: A Patent Review 2013-Present. Exp. Opin. Ther. Pat. 2018, 28(7), 541–549. DOI: 10.1080/13543776.2018.1487400.
  • Gondolova, G.; Taslimi, P.; Medjidov, A.; Farzaliyev, F.; Sujayev, A.; Huseuinova, M.; Şahin, O.; Yalçın, B.; Turkan, F.; Gulcin, I. Synthesis, Crystal Structure and Biological Evaluation of Spectroscopic Characterization of Ni(II) and Co(II) Complexes with N-salicyloil-N’-maleoil-hydrazine as Anticholinergic and Antidiabetic Agents. J. Biochem. Mol. Toxicol. 2018, 32(9), e22197. 250. DOI: 10.1002/jbt.22197.
  • Maharramova, G.; Taslimi, P.; Sujayev, A.; Farzaliyev, F.; Durmaz, L.; Gulcin, I. Synthesis, Characterization, Antioxidant, Antidiabetic, Anticholinergic, and Antiepileptic Properties of Novel N-Substituted Tetrahydropyrimidines Based on Phenylthiourea. J. Biochem. Mol. Toxicol. 2018, 32(12), e22221. DOI: 10.1002/jbt.22221.
  • Scozzafava, A.; Passaponti, M.; Supuran, C. T.; Gülçin, İ. Carbonic Anhydrase Inhibitors: Guaiacol and Catechol Derivatives Effectively Inhibit Certain Human Carbonic Anhydrase Isoenzymes (Hca I, II, IX, and XII). J. Enzyme Inhib. Med. Chem. 2015, 30(4), 586–591. DOI: 10.3109/14756366.2014.956310.
  • Tao, Y.; Zhang, Y.; Cheng, Y.; Wang, Y. Rapid Screening and Identification of α‐glucosidase Inhibitors from Mulberry Leaves Using Enzyme‐Immobilized Magnetic Beads Coupled with HPLC/MS and NMR. Biomed. Chrom. 2013, 27, 148–155. DOI: 10.1002/bmc.2761.
  • Torres-Naranjo, M.; Suarez, A.; Gilardoni, G.; Cartuche, L.; Flores, P.; Morocho, V. Chemical Constituents of Muehlenbeckia tamnifolia (Kunth) Meisn (Polygonaceae) and Its in Vitro α-Amilase and α-Glucosidase Inhibitory Activities. Molecules. 2016, 21, 1461–1465. DOI: 10.3390/molecules21111461.
  • Teng, H.; Chen, L.; Fang, T.; Yuan, B.; Lin, Q. Rb2 Inhibits α-glucosidase and Regulates Glucose Metabolism by Activating AMPK Pathways in HepG2 Cells. J. Funct. Foods. 2017, 28, 306–313. 256. DOI: 10.1016/j.jff.2016.10.033.
  • Yiğit, B.; Kaya, R.; Taslimi, P.; Işık, Y.; Karaman, M.; Yiğit, M.; Özdemir, İ.; Gulcin, I. Imidazolinium Chloride Salts Bearing Wing Tip Groups: Synthesis, Molecular Docking and Metabolic Enzymes Inhibition. J. Mol. Struct. 2019, 1179, 709–718. DOI: 10.1016/j.molstruc.2018.11.038.