Lactoferrin (LF): a natural antimicrobial protein

References

• Perez Espitia, P. J.; de Fátima Ferreira Soares, N.; Dos Reis Coimbra, J. S.; de Andrade, N. J.; Souza Cruz, R.; Alves Medeiros, E. A. Bioactive Peptides: Synthesis, Properties, and Applications in the Packaging and Preservation of Food. Compr. Rev. Food Sci. Food Saf. 2012, 11, 187–204.
   PubMed Web of Science ®Google Scholar
• Capita, R.; Alonso-Calleja, C. Antibiotic-resistant Bacteria: A Challenge for the Food Industry. Crit. Rev. Food Sci. Nutr. 2013, 53, 11–48. DOI:10.1080/10408398.2010.519837.
   PubMed Web of Science ®Google Scholar
• Francis, G.; Gallone, A.; Nychas, G.; Sofos, J.; Colelli, G.; Amodio, M.; Spano, G. Factors Affecting Quality and Safety of Fresh-cut Produce. Crit. Rev. Food Sci. Nutr. 2012, 52, 595–610. DOI: 10.1080/10408398.2010.503685.
   PubMed Web of Science ®Google Scholar
• Asghar, A.; Anjum, F. M.; Allen, J. C. Utilization of Dairy Byproduct Proteins, Surfactants, and Enzymes in Frozen Dough. Crit. Rev. Food Sci. Nutr. 2011, 51, 374–382. DOI: 10.1080/10408391003605482.
   PubMed Web of Science ®Google Scholar
• Davidson, P. M.; Harrison, M. A. Resistance and Adaptation to Food Antimicrobials, Sanitizers, and Other Process Controls. Food Technol.-Champaing Then Chicago. 2002, 56, 69–78.
   Web of Science ®Google Scholar
• Sofos, J. N.; Beuchat, L. R.; Davidson, P. M.; Johnson, E. A. Naturally Occurring Antimicrobials in Food. Regul. Toxicol. Pharmacol. 1998, 28, 71. DOI:10.1006/rtph.1998.1246.
   PubMed Web of Science ®Google Scholar
• Santos, J. C.; Sousa, R. C.; Otoni, C. G.; Moraes, A. R.; Souza, V. G.; Medeiros, E. A.; Espitia, P. J.; Pires, A. C.; Coimbra, J. S.; Soares, N. F. Nisin and Other Antimicrobial Peptides: Production, Mechanisms of Action, and Application in Active Food Packaging. Innovative Food Sci. Emerg. Technol. 2018, 48, 179–194. DOI: 10.1016/j.ifset.2018.06.008.
   Web of Science ®Google Scholar
• Aziz, M.; Karboune, S. Natural Antimicrobial/antioxidant Agents in Meat and Poultry Products as Well as Fruits and Vegetables: A Review. Crit. Rev. Food Sci. Nutr. 2018, 58, 486–511. DOI:10.1080/10408398.2016.1194256.
   PubMed Web of Science ®Google Scholar
• Madureira, A.; Tavares, T.; Gomes, A. M. P.; Pintado, M.; Malcata, F. X. Invited Review: Physiological Properties of Bioactive Peptides Obtained from Whey Proteins. J. Dairy Sci. 2010, 93, 437–455. DOI:10.3168/jds.2009-2566.
   PubMed Web of Science ®Google Scholar
• Park, Y.; Juárez, M.; Ramos, M.; Haenlein, G. Physico-chemical Characteristics of Goat and Sheep Milk. Small Ruminant Res. 2007, 68, 88–113. DOI: 10.1016/j.smallrumres.2006.09.013.
   Web of Science ®Google Scholar
• Saraswathi, N.; Sankaranarayanan, R.; Vijayan, M. Effect of Stabilizing Additives on the Structure and Hydration of Proteins: A Study Involving Monoclinic Lysozyme. Acta Crystallogr. D Biol. Crystallogr. 2002, 58, 1162–1167. DOI: 10.1107/S0907444902007126.
   PubMed Web of Science ®Google Scholar
• Abbes, C.; Mansouri, A.; Landoulsi, A. Synergistic Effect of the Lactoperoxidase System and Cinnamon Essential Oil on Total Flora and Salmonella Growth Inhibition in Raw Milk. J. Food Qual. 2018, 2018, 1–6. DOI:10.1155/2018/8547954.
   Google Scholar
• Wirjantoro, T.; Lewis, M.; Grandison, A.; Williams, G.; Delves-Broughton, J. The Effect of Nisin on the Keeping Quality of Reduced Heat-treated Milks. J. Food Prot. 2001, 64, 213–219. DOI:10.4315/0362-028x-64.2.213.
   PubMed Web of Science ®Google Scholar
• Hassoun, L. A.; Sivamani, R. K. A Systematic Review of Lactoferrin Use in Dermatology. Crit. Rev. Food Sci. Nutr. 2017, 57, 3632–3639. DOI: 10.1080/10408398.2015.1137859.
   PubMed Web of Science ®Google Scholar
• Hao, L.; Shan, Q.; Wei, J.; Ma, F.; Sun, P. Lactoferrin: Major Physiological Functions and Applications. Curr. Protein Pept. Sci. 2019, 20(2), 139–144. DOI:10.2174/1389203719666180514150921.
   PubMed Web of Science ®Google Scholar
• Zimecki, M.; Artym, J. Właściwości Terapeutyczne Białek I Peptydów Z Siary I Mleka Therapeutic Properties of Proteins and Peptides from Colostrum and Milk. Postepy Hig. Med. Dosw. (online) 2005, 59, 309–323.
   Google Scholar
• Marchewka, D.; Roterman, I.; Strus, M.; Śpiewak, K.; Majka, G. Structural Analysis of the Lactoferrin Iron Binding Pockets. Bio-Algorithms Med.-Syst. 2012, 8, 351–359.
   Google Scholar
• Collins, J. F.; Flores, S. R.; Wang, X.; Anderson, G. J. Mechanisms and Regulation of Intestinal Iron Transport, Physiology of the Gastrointestinal Tract, 6th ed.; London: Elsevier, 2018; pp 1451–1483.
   Google Scholar
• Kai, K.; Komine, Y.; Komine, K.-I.; Asai, K.-I.; Kuroishi, T.; Kozutsumi, T.; Itagaki, M.; Ohta, M.; Kumagai, K. Effects of Bovine Lactoferrin by the Intramammary Infusion in Cows with Staphylococcal Mastitis during the Early Non-lactating Period. J. Vet. Med. Sci. 2002, 64, 873–878. DOI:10.1292/jvms.64.873.
   PubMed Web of Science ®Google Scholar
• Joslin, R.; Erickson, P. S.; Santoro, H.; Whitehouse, N. L.; Schwab, C. G.; Rejman, J. Lactoferrin Supplementation to Dairy Calves1, 2. J. Dairy Sci. 2002, 85, 1237–1242. DOI: 10.3168/jds.S0022-0302(02)74187-8.
   PubMed Web of Science ®Google Scholar
• Mayeur, S.; Spahis, S.; Pouliot, Y.; Levy, E. Lactoferrin, a Pleiotropic Protein in Health and Disease. Antioxid. Redox Signaling. 2016, 24, 813–836. DOI: 10.1089/ars.2015.6458.
   PubMed Web of Science ®Google Scholar
• Manzoni, P.;. Clinical Studies of Lactoferrin in Neonates and Infants: An Update. Breastfeeding Med 2019, 14(S1), S–25, Clinical Aspects of Human MilkOpen AccessOpen Access license.
   PubMedGoogle Scholar
• Sanchez, L.; Calvo, M.; Brock, J. H. Biological Role of Lactoferrin. Arch. Dis. Childhood. 1992, 67, 657. DOI: 10.1136/adc.67.5.657.
   PubMed Web of Science ®Google Scholar
• Spik, G.; Coddeville, B.; Mazurier, J.; Bourne, Y.; Cambillaut, C.; Montreuil, J. Primary and Three-dimensional Structure of Lactotransferrin (Lactoferrin) Glycans, Lactoferrin; Springer: New York, 1994; pp 21–32.
   Google Scholar
• Mousavi KhaneGhah, A.; Hashemi, S. M. B.; Fracassetti, E. Ş. I.; Limbo, D. Efficacy of Antimicrobial Agents for Food Contact Applications: Biological Activity, Incorporation into Packaging, and Assessment Methods: A Review. J. Food Prot. 2018, 81, 1142–1156. DOI: 10.4315/0362-028X.JFP-17-509.
   PubMed Web of Science ®Google Scholar
• Pierce, A.; Colavizza, D.; Benaissa, M.; Maes, P.; Tartar, A.; Montreuil, J.; Spik, G. Molecular Cloning and Sequence Analysis of Bovine Lactotransferrin. Eur.J. Biochem. 1991, 196, 177–184. DOI:10.1111/j.1432-1033.1991.tb15801.x.
   PubMedGoogle Scholar
• Bellamy, W.; Takase, M.; Yamauchi, K.; Wakabayashi, H.; Kawase, K.; Tomita, M. Identification of the Bactericidal Domain of Lactoferrin. Biochim. Biophys. Acta, Protein Struct. Mol. Enzymol. 1992, 1121, 130–136. DOI: 10.1016/0167-4838(92)90346-F.
   PubMed Web of Science ®Google Scholar
• Teraguchi, S.; Shin, K.; Ozawa, K.; Nakamura, S.; Fukuwatari, Y.; Tsuyuki, S.; Namihira, H.; Shimamura, S. Bacteriostatic Effect of Orally Administered Bovine Lactoferrin on Proliferation of Clostridium Species in the Gut of Mice Fed Bovine Milk. Appl. Environ. Microbiol. 1995, 61, 501–506.
   PubMed Web of Science ®Google Scholar
• Farnaud, S.; Evans, R. W. Immunological System? New Res. Immunol. 2005, 47.
   Google Scholar
• Brisson, G.; Britten, M.; Pouliot, Y. Heat-induced Aggregation of Bovine Lactoferrin at Neutral pH: Effect of Iron Saturation. Int. Dairy J. 2007, 17, 617–624. DOI: 10.1016/j.idairyj.2006.09.002.
   Web of Science ®Google Scholar
• Struff, W.; Sprotte, G. Bovine Colostrum as a Biologic in Clinical Medicine: Review. Int. J. Clin. Pharmacol. Therapeut. 2007, 45, 193–202. DOI: 10.5414/CPP45193.
   PubMed Web of Science ®Google Scholar
• Guedes, J.-P.; Pereira, C.-S.; Rodrigues, L.-R.; Côrte-Real, M. Bovine Milk Lactoferrin Selectively Kills Highly Metastatic Prostate Cancer PC-3 and Osteosarcoma MG-63 Cells in Vitro. Front. Oncol. June 04, 2018. DOI:10.3389/fonc.2018.00200.
   PubMed Web of Science ®Google Scholar
• Restani, P.; Beretta, B.; Fiocchi, A.; Ballabio, C.; Galli, C. L. Cross-reactivity between Mammalian Proteins. Ann. Allergy Asthma Immunol. 2002, 89, 11–15. DOI: 10.1016/S1081-1206(10)62116-3.
   PubMed Web of Science ®Google Scholar
• Stumpf, P.; Welsch, U. Secretory and Defensive Functions of the Duct System of the Lactating Mammary Gland of the African Elephant (loxodonta Africana, Proboscidea). Zoomorphology. 2004, 123, 155–167. DOI: 10.1007/s00435-004-0098-3.
   Web of Science ®Google Scholar
• Baker, E.; Baker, H. Lactoferrin, Cellular and Molecular Life Sciences. 2005, 62, 2531.
   Google Scholar
• El-Hatmi, H.; Girardet, J.-M.; Gaillard, J.-L.; Yahyaoui, M. H.; Attia, H. Characterisation of Whey Proteins of Camel (camelus Dromedarius) Milk and Colostrum. Small Ruminant Res. 2007, 70, 267–271. DOI: 10.1016/j.smallrumres.2006.04.001.
   Web of Science ®Google Scholar
• Shin, K.; Yamauchi, K.; Teraguchi, S.; Hayasawa, H.; Tomita, M.; Otsuka, Y.; Yamazaki, S. Antibacterial Activity of Bovine Lactoferrin and Its Peptides against Enterohaemorrhagic Escherichia Coli O157: H7. Lett Appl. Microbiol. 1998, 26, 407–411.
   PubMed Web of Science ®Google Scholar
• Lee, T.; Yu, S.; Nam, M.; Kim, S.; Lee, K.; Yu, D.; Shimazaki, K. Polymorphic Sequence of Korean Native Goat Lactoferrin Exhibiting Greater Antibacterial Activity. Anim Genet. 1997, 28, 367–369.
   PubMed Web of Science ®Google Scholar
• Farnaud, S.; Evans, R. W. Lactoferrin—A Multifunctional Protein with Antimicrobial Properties. Mol. Immunol. 2003, 40, 395–405. DOI: 10.1016/s0161-5890(03)00152-4.
   PubMed Web of Science ®Google Scholar
• van Veen, H. A.; Geerts, M. E.; van Berkel, P. H.; Nuijens, J. H. The Role of N‐linked Glycosylation in the Protection of Human and Bovine Lactoferrin against Tryptic Proteolysis. Eur.J. Biochem. 2004, 271, 678–684. DOI: 10.1111/j.1432-1033.2003.03965.x.
   PubMedGoogle Scholar
• Stanic, D.; Radosavljevic, J.; Stojadinovic, M.; Velickovic, T. C. Application of Ion Exchanger in the Separation of Whey Proteins and Lactin from Milk Whey, Ion Exchange Technology II; Springer: Dordrecht,  Netherlands, 2012; pp 35–63.
   Google Scholar
• Adam, V.; Zitka, O.; Dolezal, P.; Zeman, L.; Horna, A.; Hubalek, J.; Sileny, J.; Krizkova, S.; Trnkova, L.; Kizek, R. Lactoferrin Isolation Using Monolithic Column Coupled with Spectrometric or Micro-amperometric Detector. Sensors. 2008, 8, 464–487. DOI: 10.3390/s8010464.
   PubMed Web of Science ®Google Scholar
• Bylund, G.;. Dairy Processing Handbook; Tetra Pak Processing Systems AB, Lund, Sweden, 2003.
   Google Scholar
• Doultani, S.; Turhan, K. N.; Etzel, M. R. Fractionation of Proteins from Whey Using Cation Exchange Chromatography. Process Biochem. 2004, 39, 1737–1743. DOI: 10.1016/j.procbio.2003.07.005.
   Web of Science ®Google Scholar
• Hahn, R.; Schulz, P.; Schaupp, C.; Jungbauer, A. Bovine Whey Fractionation Based on Cation-exchange Chromatography1. J. Chromatogr. A. 1998, 795, 277–287. DOI: 10.1016/s0021-9673(97)01030-3.
   PubMed Web of Science ®Google Scholar
• Tomita, M.; Wakabayashi, H.; Yamauchi, K.; Teraguchi, S.; Hayasawa, H. Bovine Lactoferrin and Lactoferricin Derived from Milk: Production and Applications. Biochem. Cell Biol. 2002, 80, 109–112.
   PubMed Web of Science ®Google Scholar
• Ye, X.; Yoshida, S.; Ng, T. Isolation of Lactoperoxidase, Lactoferrin, α-lactalbumin, β-lactoglobulin B and β-lactoglobulin A from Bovine Rennet Whey Using Ion Exchange Chromatography. Int. J. Biochem. Cell Biol. 2000, 32, 1143–1150. DOI: 10.1016/S1357-2725(00)00063-7.
   PubMed Web of Science ®Google Scholar
• Nuyens, J. H.; Van Veen, H. H. Isolation of Lactoferrin from Milk; Google Patents, USA, 1999.
   Google Scholar
• Fee, C. J.; Chand, A. Capture of Lactoferrin and Lactoperoxidase from Raw Whole Milk by Cation Exchange Chromatography. Sep. Purif. Technol. 2006, 48, 143–149. DOI: 10.1016/j.seppur.2005.07.011.
   Web of Science ®Google Scholar
• Lu, R. R.; Xu, S. Y.; Wang, Z.; Yang, R. J. Isolation of Lactoferrin from Bovine Colostrum by Ultrafiltration Coupled with Strong Cation Exchange Chromatography on a Production Scale. J. Membr. Sci. 2007, 297, 152–161. DOI: 10.1016/j.memsci.2007.03.039.
   Web of Science ®Google Scholar
• Conesa, C.; Sánchez, L.; Rota, C.; Pérez, M.-D.; Calvo, M.; Farnaud, S.; Evans, R. W. Isolation of Lactoferrin from Milk of Different Species: Calorimetric and Antimicrobial Studies. Comp. Biochem. Physiol. B. 2008, 150, 131–139. DOI:10.1016/j.cbpb.2008.02.005.
   PubMed Web of Science ®Google Scholar
• Chen, L.; Guo, C.; Guan, Y.; Liu, H. Isolation of Lactoferrin from Acid Whey by Magnetic Affinity Separation. Sep. Purif. Technol. 2007, 56, 168–174. DOI: 10.1016/j.seppur.2007.01.019.
   Web of Science ®Google Scholar
• UCHIDA, T.;. Sequential Separation of Lactoferrin, Lactoperoxidase, and Secretory Component by Sulfate-linked Ion-exchange Chromatography. Milchwissenschaft. 2003, 58, 482–486.
   Google Scholar
• Grasseli, M.; Cascone, O. Separation of Lactoferrin from Bovine Whey by Dye Affinity Chromatography. Ned. Melk En Zuiveltijdschrift. 1996, 50, 551–561.
   Google Scholar
• Al-Mashikhi, S. A.; Li-Chan, E.; Nakai, S. Separation of Immunoglobulins and Lactoferrin from Cheese Whey by Chelating Chromatography. J. Dairy Sci. 1988, 71, 1747–1755. DOI: 10.3168/jds.S0022-0302(88)79741-6.
   PubMed Web of Science ®Google Scholar
• Noh, K.-H.; Rhee, M.-S.; Imm, J.-Y. Separation of Lactoferrin from Model Whey Protein Mixture by Reverse Micelles Formed by Cationic Surfactant. Food Sci. Biotechnol. 2005, 14, 131–136.
   Web of Science ®Google Scholar
• Han, Z.-S.; Li, Q.-W.; Zhang, Z.-Y.; Xiao, B.; Gao, D.-W.; Wu, S.-Y.; Li, J.; Zhao, H.-W.; Jiang, Z.-L.; Hu, J.-H. High-level Expression of Human Lactoferrin in the Milk of Goats by Using Replication-defective Adenoviral Vectors. Protein Expression Purif. 2007, 53, 225–231. DOI: 10.1016/j.pep.2006.11.019.
   PubMed Web of Science ®Google Scholar
• Yu, H.; Chen, J.; Sun, W.; Liu, S.; Zhang, A.; Xu, X.; Wang, X.; He, Z.; Liu, G.; Cheng, G. The Dominant Expression of Functional Human Lactoferrin in Transgenic Cloned Goats Using a Hybrid Lactoferrin Expression Construct. J. Biotechnol. 2012, 161, 198–205. DOI: 10.1016/j.jbiotec.2012.06.035.
   PubMed Web of Science ®Google Scholar
• Shashikumar, C.; Puranik, D., Study on Use of Lactoferrin for the Biopreservation of Paneer. (2011).
   Google Scholar
• Chantaysakorn, P.; Richter, R. Antimicrobial Properties of Pepsin-digested Lactoferrin Added to Carrot Juice and Filtrates of Carrot Juice. J. Food Prot. 2000, 63, 376–380. DOI: 10.4315/0362-028x-63.3.376.
   PubMed Web of Science ®Google Scholar
• Umuhumuza, L. C.; Wei-min, N.; Sun, X. Effect of Bovine Lactoferrin and Casein Peptide Powder on Microbial Growth and Glucose Utilization by Microorganisms in Pork Meat during Storage at 4 C. Pak. J. Nutr. 2011, 10, 208–213. DOI: 10.3923/pjn.2011.208.213.
   Google Scholar
• Al-Nabulsi, A. A.; Holley, R. A. Effects on Escherichia Coli O157: H7 and Meat Starter Cultures of Bovine Lactoferrin in Broth and Microencapsulated Lactoferrin in Dry Sausage Batters. Int. J. Food Microbiol. 2007, 113, 84–91. DOI: 10.1016/j.ijfoodmicro.2006.07.019.
   PubMed Web of Science ®Google Scholar
• Wakabayashi, H.; Yamauchi, K.; Takase, M. Lactoferrin Research, Technology and Applications. Int. Dairy J. 2006, 16, 1241–1251. DOI: 10.1016/j.idairyj.2006.06.013.
   Web of Science ®Google Scholar
• Appendini, P.; Hotchkiss, J. H. Review of Antimicrobial Food Packaging. Innovative Food Sci. Emerg. Technol. 2002, 3, 113–126. DOI: 10.1016/S1466-8564(02)00012-7.
   Google Scholar
• Brown, C. A.; Wang, B.; Oh, J.-H. Antimicrobial Activity of Lactoferrin against Foodborne Pathogenic Bacteria Incorporated into Edible Chitosan Film. J. Food Prot. 2008, 71, 319–324. DOI: 10.4315/0362-028x-71.2.319.
   PubMed Web of Science ®Google Scholar
• Brown, C.; Wang, B.; Jun, S.; OH, J., Antimicrobial Efficacy of Lactoferrin in Chitosan-based Edible Film against Foodborne Pathogenic Bacteria, 2004 IFT Annual Meeting, July 12-16-Las Vegas, NV, 2004.
   Google Scholar
• Oh, J.; Wang, B.; Dessai, A.; Aglan, H., The Efficacy of Natural Anti-microbial Agent Lactoferrin in Protein-based Edible Films against E. Col, Food Packaging: General IFT Annual Meeting, Chicago, July, 2003.
   Google Scholar
• Rollini, M.; Nielsen, T.; Musatti, A.; Limbo, S.; Piergiovanni, L.; Hernandez Munoz, P.; Gavara, R. Antimicrobial Performance of Two Different Packaging Materials on the Microbiological Quality of Fresh Salmon. Coatings. 2016, 6, 6. DOI: 10.3390/coatings6010006.
   Web of Science ®Google Scholar
• Juliano, R.;. Drug Delivery Systems: A Brief Review. Can. J. Physiol. Pharmacol. 1978, 56, 683–690. DOI: 10.1139/y78-112.
   PubMed Web of Science ®Google Scholar
• Were, L. M.; Bruce, B.; Davidson, P. M.; Weiss, J. Encapsulation of Nisin and Lysozyme in Liposomes Enhances Efficacy against Listeria Monocytogenes. J. Food Prot. 2004, 67, 922–927. DOI: 10.4315/0362-028x-67.5.922.
   PubMed Web of Science ®Google Scholar
• Ghalanbor, Z.; Körber, M.; Bodmeier, R. Improved Lysozyme Stability and Release Properties of Poly (lactide-co-glycolide) Implants Prepared by Hot-melt Extrusion. Pharm. Res. 2010, 27, 371–379. DOI: 10.1007/s11095-009-0033-x.
   PubMed Web of Science ®Google Scholar
• Onishi, H.; Machida, Y.; Koyama, K. Preparation and in Vitro Characteristics of Lactoferrin-loaded Chitosan Microparticles. Drug Dev. Ind. Pharm. 2007, 33, 641–647. DOI: 10.1080/03639040601085334.
   PubMed Web of Science ®Google Scholar
• Cao-Hoang, L.; Grégoire, L.; Chaine, A.; Waché, Y. Importance and Efficiency of In-depth Antimicrobial Activity for the Control of Listeria Development with Nisin-incorporated Sodium Caseinate Films. Food Control. 2010, 21, 1227–1233. DOI: 10.1016/j.foodcont.2010.02.004.
   Web of Science ®Google Scholar
• Nostro, A.; Scaffaro, R.; Ginestra, G.; D’Arrigo, M.; Botta, L.; Marino, A.; Bisignano, G. Control of Biofilm Formation by Poly-ethylene-co-vinyl Acetate Films Incorporating Nisin. Appl. Microbiol. Biotechnol. 2010, 87, 729–737. DOI: 10.1007/s00253-010-2598-z.
   PubMed Web of Science ®Google Scholar
• Lungu, B.; Johnson, M. G. Potassium Sorbate Does Not Increase Control of Listeria Monocytogenes When Added to Zein Coatings with Nisin on the Surface of Full Fat Turkey Frankfurter Pieces in a Model System at 4 C. J. Food Sci. 2005, 70, M95–M99. DOI: 10.1111/j.1365-2621.2005.tb07109.x.
   Web of Science ®Google Scholar
• Janes, M.; Kooshesh, S.; Johnson, M. Control of Listeria Monocytogenes on the Surface of Refrigerated, Ready‐to‐eat Chicken Coated with Edible Zein Film Coatings Containing Nisin And/or Calcium Propionate. J. Food Sci. 2002, 67, 2754–2757. DOI: 10.1111/jfds.2002.67.issue-7.
   Web of Science ®Google Scholar
• Dawson, P.; Carl, G.; Acton, J.; Han, I. Effect of Lauric Acid and Nisin-impregnated Soy-based Films on the Growth of Listeria Monocytogenes on Turkey Bologna. Poultr. Sci. 2002, 81, 721–726. DOI: 10.1093/ps/81.5.721.
   PubMed Web of Science ®Google Scholar
• Palmano, K.; Ramos, R.; Watson, M.; Callon, K.; Cornish, J. Survival and Bone-active Properties of Bovine Lactoferrin Supplemented into Stirred Yoghurt. Int. Dairy J. 2011, 21, 477–483. DOI: 10.1016/j.idairyj.2011.02.006.
   Web of Science ®Google Scholar
• Takayama, Y.; Mizumachi, K. Effect of Bovine Lactoferrin on Extracellular Matrix Calcification by Human Osteoblast-like Cells. Biosci., Biotechnol., Biochem. 2008, 72, 226–230. DOI: 10.1271/bbb.70465.
   PubMed Web of Science ®Google Scholar
• Guan, R.; Ma, J.; Wu, Y.; Lu, F.; Xiao, C.; Jiang, H.; Kang, T. Development and Characterization of Lactoferrin Nanoliposome: Cellular Uptake and Stability. Nanoscale Res. Lett. 2012, 7, 679. DOI: 10.1186/1556-276X-7-679.
   PubMed Web of Science ®Google Scholar
• Kawaguchi, S.; Hayashi, T.; Masano, H.; Okuyama, K.; Suzuki, T.; Kawase, K. Effect of Lactoferrin-enriched Infant Formula on Low Birth Weight Infants. Shuusankiigaku. 1989, 19, 125–130.
   Google Scholar
• Wisgrill, L.; Wessely, I.; Spittler, A.; Förster‐Waldl, E.; Berger, A.; Sadeghi, K. Human Lactoferrin Attenuates the Proinflammatory Response of Neonatal Monocyte‐derived Macrophages. Clin. Exp. Immunol. 2018, 192, 315–324. DOI: 10.1111/cei.13108.
   PubMed Web of Science ®Google Scholar
• Piccinini, R.; Binda, E.; Belotti, M.; Dapra, V.; Zecconi, A. Evaluation of Milk Components during Whole Lactation in Healthy Quarters. J. Dairy Res. 2007, 74, 226–232. DOI: 10.1017/S0022029906002317.
   PubMed Web of Science ®Google Scholar
• Schoepfer, A. M.; Trummler, M.; Seeholzer, P.; Criblez, D. H.; Seibold, F. Accuracy of Four Fecal Assays in the Diagnosis of Colitis. Dis. Colon Rectum. 2007, 50, 1697–1706. DOI: 10.1007/s10350-007-0303-9.
   PubMed Web of Science ®Google Scholar
• Scarpa, M.; D’Incà, R.; Basso, D.; Ruffolo, C.; Polese, L.; Bertin, E.; Luise, A.; Frego, M.; Plebani, M.; Sturniolo, G. C. Fecal Lactoferrin and Calprotectin after Ileocolonic Resection for Crohn’s Disease. Dis. Colon Rectum. 2007, 50, 861–869. DOI: 10.1007/s10350-007-0225-6.
   PubMed Web of Science ®Google Scholar
• Giuffrè, G.; Barresi, V.; Skliros, C.; Barresi, G.; Tuccari, G. Immunoexpression of Lactoferrin in Human Sporadic Renal Cell Carcinomas. Oncol. Rep. 2007, 17, 1021–1026.
   PubMed Web of Science ®Google Scholar
• Yoshise, R. E.; Matsumoto, M.; Chiji, H.; Kuwata, H.; Shin, K.; Yamauchi, K.; Tamura, Y.; Tanaka, T.; Kumura, K.; Shimazaki, K. Profiles of Bovine Lactoferrin in the Gastrointestinal Tracts of Rats as Observed by ELISA, Western Blotting and SELDI-affinity MS. Milchwissenschaft. 2007, 62, 446–449.
   Google Scholar
• Beeckman, D. S. A.; Van Droogenbroeck, C. M.; De Cock, B. J.; Van Oostveldt, P.; Vanrompay, D. C. Effect of Ovotransferrin and Lactoferrins on Chlamydophila Psittaci Adhesion and Invasion in HD11 Chicken Macrophages. Vet. Res. 2007, 38, 729–739. DOI: 10.1051/vetres:2007028.
   PubMed Web of Science ®Google Scholar
• Yuan, Y.; Wu, Q.; Cheng, G.; Liu, X.; Liu, S.; Luo, J.; Zhang, A.; Bian, L.; Chen, J.; Lv, J. Recombinant Human Lactoferrin Enhances the Efficacy of Triple Therapy in Mice Infected with Helicobacter Pylori. Int.J. Mol. Med. 2015, 36, 363–368. DOI: 10.3892/ijmm.2015.2251.
   PubMed Web of Science ®Google Scholar
• Zullo, A.; De Francesco, V.; Scaccianoce, G.; Manes, G.; Efrati, C.; Hassan, C.; Maconi, G.; Piglionica, D.; Cannaviello, C.; Panella, C. Helicobacter Pylori Eradication with either Quadruple Regimen with Lactoferrin or Levofloxacin-based Triple Therapy: A Multicentre Study. Digestive Liver Dis. 2007, 39, 806–810. DOI: 10.1016/j.dld.2007.05.021.
   Web of Science ®Google Scholar
• Welsh, K. J.; Hwang, S.-A.; Boyd, S.; Kruzel, M. L.; Hunter, R. L.; Actor, J. K. Influence of Oral Lactoferrin on Mycobacterium Tuberculosis Induced Immunopathology. Tuberculosis. 2011, 91, S105–S113. DOI: 10.1016/j.tube.2011.10.019.
   PubMedGoogle Scholar
• Hwang, S.-A.; Wilk, K. M.; Bangale, Y. A.; Kruzel, M. L.; Actor, J. K. Lactoferrin Modulation of IL-12 and IL-10 Response from Activated Murine Leukocytes. Med. Microbiol. Immunol. 2007, 196, 171–180. DOI: 10.1007/s00430-007-0041-6.
   PubMed Web of Science ®Google Scholar
• Mistry, N.; Drobni, P.; Näslund, J.; Sunkari, V. G.; Jenssen, H.; Evander, M. The Anti-papillomavirus Activity of Human and Bovine Lactoferricin. Antiviral Res. 2007, 75, 258–265. DOI: 10.1016/j.antiviral.2007.03.012.
   PubMed Web of Science ®Google Scholar
• Kaito, M.; Iwasa, M.; Fujita, N.; Kobayashi, Y.; Kojima, Y.; Ikoma, J.; Imoto, I.; Adachi, Y.; Hamano, H.; Yamauchi, K. Effect of Lactoferrin in Patients with Chronic Hepatitis C: Combination Therapy with Interferon and Ribavirin. J. Gastroenterol. Hepatol. 2007, 22, 1894–1897. DOI: 10.1111/j.1440-1746.2007.04858.x.
   PubMed Web of Science ®Google Scholar
• Wang, H.; Ye, X.; Ng, T. First Demonstration of an Inhibitory Activity of Milk Proteins against Human Immunodeficiency Virus-1 Reverse Transcriptase and the Effect of Succinylation. Life Sci. 2000, 67, 2745–2752. DOI: 10.1016/s0024-3205(00)00853-5.
   PubMed Web of Science ®Google Scholar
• McCann, K.; Lee, A.; Wan, J.; Roginski, H.; Coventry, M. The Effect of Bovine Lactoferrin and Lactoferricin B on the Ability of Feline Calicivirus (a Norovirus Surrogate) and Poliovirus to Infect Cell Cultures. J. Appl. Microbiol. 2003, 95, 1026–1033.
   PubMed Web of Science ®Google Scholar
• Berkhout, B.; van Wamel, J. L.; Beljaars, L.; Meijer, D. K.; Visser, S.; Floris, R. Characterization of the anti-HIV Effects of Native Lactoferrin and Other Milk Proteins and Protein-derived Peptides. Antiviral Res. 2002, 55, 341–355.
   PubMed Web of Science ®Google Scholar
• Van der Strate, B.; Beljaars, L.; Molema, G.; Harmsen, M.; Meijer, D. Antiviral Activities of Lactoferrin. Antiviral Res. 2001, 52, 225–239.
   PubMed Web of Science ®Google Scholar
• Florian, P. E.; Macovei, A.; Lazar, C.; Milac, A. L.; Sokolowska, I.; Darie, C. C.; Evans, R. W.; Roseanu, A.; Branza‐Nichita, N. Characterization of the anti‐HBV Activity of HLP1–23, a Human Lactoferrin‐derived Peptide. J. Med. Virol. 2013, 85, 780–788. DOI:10.1002/jmv.23549.
   PubMed Web of Science ®Google Scholar
• Liao, Y.; El-Fakkarany, E.; Lönnerdal, B.; Redwan, E. M. Inhibitory Effects of Native and Recombinant Full-length Camel Lactoferrin and Its N and C Lobes on Hepatitis C Virus Infection of Huh7. 5 Cells. J. Med. Microbiol. 2012, 61, 375–383. DOI: 10.1099/jmm.0.033894-0.
   PubMed Web of Science ®Google Scholar
• Redwan, E. M.; EL-Fakharany, E. M.; Uversky, V. N.; Linjawi, M. H. Screening the Anti Infectivity Potentials of Native N-and C-lobes Derived from the Camel Lactoferrin against Hepatitis C Virus. BMC Complementary Altern. Med. 2014, 14, 219. DOI: 10.1186/1472-6882-14-219.
   PubMed Web of Science ®Google Scholar
• EL-Fakharany, E. M.; Sánchez, L.; Al-Mehdar, H. A.; Redwan, E. M. Effectiveness of Human, Camel, Bovine and Sheep Lactoferrin on the Hepatitis C Virus Cellular Infectivity: Comparison Study. Virol. J. 2013, 10, 199. DOI: 10.1186/1743-422X-10-199.
   PubMed Web of Science ®Google Scholar
• Pietrantoni, A.; Di Biase, A. M.; Tinari, A.; Marchetti, M.; Valenti, P.; Seganti, L.; Superti, F. Bovine Lactoferrin Inhibits Adenovirus Infection by Interacting with Viral Structural Polypeptides. Antimicrob. Agents Chemother. 2003, 47, 2688–2691. DOI: 10.1128/aac.47.8.2688-2691.2003.
   PubMed Web of Science ®Google Scholar
• Arnold, D.; Di Biase, A. M.; Marchetti, M.; Pietrantoni, A.; Valenti, P.; Seganti, L.; Superti, F. Antiadenovirus Activity of Milk Proteins: Lactoferrin Prevents Viral Infection. Antiviral Res. 2002, 53, 153–158.
   PubMed Web of Science ®Google Scholar
• Murphy, M.; Kariwa, H.; Mizutani, T.; Yoshimatsu, K.; Arikawa, J.; Takashima, I. In Vitro Antiviral Activity of Lactoferrin and Ribavirin upon Hantavirus. Arch. Virol. 2000, 145, 1571–1582. DOI: 10.1007/s007050070077.
   PubMed Web of Science ®Google Scholar
• Waarts, B.-L.; Aneke, O. J.; Smit, J. M.; Kimata, K.; Bittman, R.; Meijer, D. K.; Wilschut, J. Antiviral Activity of Human Lactoferrin: Inhibition of Alphavirus Interaction with Heparan Sulfate. Virology. 2005, 333, 284–292. DOI: 10.1016/j.virol.2005.01.010.
   PubMed Web of Science ®Google Scholar
• Taha, S. H.; Mehrez, M. A.; Sitohy, M. Z.; Dawood, A. G. I. A.; Abd-El Hamid, M. M.; Kilany, W. H. Effectiveness of Esterified Whey Proteins Fractions against Egyptian Lethal Avian Influenza A (H5N1). Virol. J. 2010, 7, 330. DOI: 10.1186/1743-422X-7-330.
   PubMed Web of Science ®Google Scholar
• Shin, K.; Wakabayashi, H.; Yamauchi, K.; Teraguchi, S.; Tamura, Y.; Kurokawa, M.; Shiraki, K. Effects of Orally Administered Bovine Lactoferrin and Lactoperoxidase on Influenza Virus Infection in Mice. J. Med. Microbiol. 2005, 54, 717–723. DOI: 10.1099/jmm.0.46018-0.
   PubMed Web of Science ®Google Scholar
• Ammendolia, M. G.; Agamennone, M.; Pietrantoni, A.; Lannutti, F.; Siciliano, R. A.; De Giulio, B.; Amici, C.; Superti, F. Bovine Lactoferrin-derived Peptides as Novel Broad-spectrum Inhibitors of Influenza Virus. Pathog. Global Health. 2012, 106, 12–19. DOI: 10.1179/2047773212Y.0000000004.
   PubMed Web of Science ®Google Scholar
• Pietrantoni, A.; Ammendolia, M. G.; Superti, F. Bovine Lactoferrin: Involvement of Metal Saturation and Carbohydrates in the Inhibition of Influenza Virus Infection. Biochem. Cell Biol. 2012, 90, 442–448. DOI: 10.1139/o11-072.
   PubMedGoogle Scholar
• Gualdi, L.; Mertz, S.; Gomez, A. M.; Ramilo, O.; Wittke, A.; Mejias, A. Lack of Effect of Bovine Lactoferrin in Respiratory Syncytial Virus Replication and Clinical Disease Severity in the Mouse Model. Antiviral Res. 2013, 99, 188–195. DOI: 10.1016/j.antiviral.2013.05.013.
   PubMed Web of Science ®Google Scholar
• Pietrantoni, A.; Ammendolia, M. G.; Tinari, A.; Siciliano, R.; Valenti, P.; Superti, F. Bovine Lactoferrin Peptidic Fragments Involved in Inhibition of Echovirus 6 in Vitro Infection. Antiviral Res. 2006, 69, 98–106. DOI: 10.1016/j.antiviral.2005.10.006.
   PubMed Web of Science ®Google Scholar
• Furlund, C. B.; Kristoffersen, A. B.; Devold, T. G.; Vegarud, G. E.; Jonassen, C. M. Bovine Lactoferrin Digested with Human Gastrointestinal Enzymes Inhibits Replication of Human Echovirus 5 in Cell Culture. Nutr. Res. 2012, 32, 503–513. DOI: 10.1016/j.nutres.2012.06.006.
   PubMed Web of Science ®Google Scholar
• Chen, H.-L.; Wang, L.-C.; Chang, C.-H.; Yen, -C.-C.; Cheng, W. T.; Wu, S.-C.; Hung, C.-M.; Kuo, M.-F.; Chen, C.-M. Recombinant Porcine Lactoferrin Expressed in the Milk of Transgenic Mice Protects Neonatal Mice from a Lethal Challenge with Enterovirus Type 71. Vaccine. 2008, 26, 891–898. DOI: 10.1016/j.vaccine.2007.12.013.
   PubMed Web of Science ®Google Scholar
• Marchetti, M.; Ammendolia, M.; Superti, F. Glycosaminoglycans are Not Indispensable for the Anti-herpes Simplex Virus Type 2 Activity of Lactoferrin. Biochimie. 2009, 91, 155–159. DOI: 10.1016/j.biochi.2008.04.015.
   PubMed Web of Science ®Google Scholar
• Superti, F.; Ammendolia, M.; Valenti, P.; Seganti, L. Antirotaviral Activity of Milk Proteins: Lactoferrin Prevents Rotavirus Infection in the Enterocyte-like Cell Line HT-29. Med. Microbiol. Immunol. 1997, 186, 83–91.
   PubMed Web of Science ®Google Scholar
• Lupetti, A.; Brouwer, C. P.; Bogaards, S. J.; Welling, M. M.; de Heer, E.; Campa, M.; van Dissel, J. T.; Friesen, R. H.; Nibbering, P. H. Human Lactoferrin-derived Peptide’s Antifungal Activities against Disseminated Candida Albicans Infection. J. Infect. Dis. 2007, 196, 1416–1424. DOI: 10.1086/522427.
   PubMed Web of Science ®Google Scholar
• Enrique, M.; Marcos, J. F.; Yuste, M.; Martínez, M.; Vallés, S.; Manzanares, P. Antimicrobial Action of Synthetic Peptides Towards Wine Spoilage Yeasts. Int. J. Food Microbiol. 2007, 118, 318–325. DOI: 10.1016/j.ijfoodmicro.2007.07.049.
   PubMed Web of Science ®Google Scholar
• Parodi, P.;. A Role for Milk Proteins and Their Peptides in Cancer Prevention. Curr. Pharm. Des. 2007, 13, 813–828. DOI: 10.2174/138161207780363059.
   PubMed Web of Science ®Google Scholar
• Buccigrossi, V.; De Marco, G.; Bruzzese, E.; Ombrato, L.; Bracale, I.; Polito, G.; Guarino, A. Lactoferrin Induces Concentration-dependent Functional Modulation of Intestinal Proliferation and Differentiation. Pediatr. Res. 2007, 61, 410. DOI: 10.1203/pdr.0b013e3180332c8d.
   PubMed Web of Science ®Google Scholar
• Mohan, K. C.; Gunasekaran, P.; Varalakshmi, E.; Hara, Y.; Nagini, S. In Vitro Evaluation of the Anticancer Effect of Lactoferrin and Tea Polyphenol Combination on Oral Carcinoma Cells. Cell Biol. Int. 2007, 31, 599–608. DOI: 10.1016/j.cellbi.2006.11.034.
   PubMed Web of Science ®Google Scholar
• Tomita, M.; Wakabayashi, H.; Shin, K.; Yamauchi, K.; Yaeshima, T.; Iwatsuki, K. Twenty-five Years of Research on Bovine Lactoferrin Applications. Biochimie. 2009, 91, 52–57. DOI: 10.1016/j.biochi.2008.05.021.
   PubMed Web of Science ®Google Scholar
• Shan, T.; Wang, Y.; Wang, Y.; Liu, J.; Xu, Z. Effect of Dietary Lactoferrin on the Immune Functions and Serum Iron Level of Weanling Piglets. J. Anim. Sci. 2007, 85, 2140–2146. DOI: 10.2527/jas.2006-754.
   PubMed Web of Science ®Google Scholar
• Duran, R.; Deschler, C.; Precigou, S.; Goulas, P. Degradation of Chlorophenols by Phanerochaete Chrysosporium: Effect of 3, 4-dichlorophenol on Extracellular Peroxidase Activities. Appl. Microbiol. Biotechnol. 2002, 59, 284–288. DOI: 10.1007/s00253-002-0988-6.
   PubMed Web of Science ®Google Scholar
• Diarra, M.; Petitclerc, D.; Lacasse, P. Effect of Lactoferrin in Combination with Penicillin on the Morphology and the Physiology of Staphylococcus Aureus Isolated from Bovine Mastitis1, 2. J. Dairy Sci. 2002, 85, 1141–1149. DOI: 10.3168/jds.S0022-0302(02)74176-3.
   PubMed Web of Science ®Google Scholar
• Naot, D.; Palmano, K.; Cornish, J. Lactoferrin–A Potential Anabolic Intervention in Osteoporosis; Osteoporosis, InTech: London, UK, 2012.
   Google Scholar
• Fischer, R.; Debbabi, H.; Blais, A.; Dubarry, M.; Rautureau, M.; Boyaka, P. N.; Tome, D. Uptake of Ingested Bovine Lactoferrin and Its Accumulation in Adult Mouse Tissues. Int. Immunopharmacol. 2007, 7, 1387–1393. DOI: 10.1016/j.intimp.2007.05.019.
   PubMed Web of Science ®Google Scholar
• Morita, Y.; Ono-Ohmachi, A.; Higurashi, S.; Matsuyama, H.; Serizawa, A.; Takeya, T. The Bone-strengthening Activity of Milk Basic Protein Is Not Dependent on Lactoferrin. Int. Dairy J. 2012, 27, 40–46. DOI: 10.1016/j.idairyj.2012.07.003.
   Web of Science ®Google Scholar
• Wakabayashi, H.; Yamauchi, K.; Kobayashi, T.; Yaeshima, T.; Iwatsuki, K.; Yoshie, H. Inhibitory Effects of Lactoferrin on Growth and Biofilm Formation of Porphyromonas Gingivalis and Prevotella Intermedia. Antimicrob. Agents Chemother. 2009, 53, 3308–3316. DOI: 10.1128/AAC.01688-08.
   PubMed Web of Science ®Google Scholar
• Rodrigues, L.; Teixeira, J.; Schmitt, F.; Paulsson, M.; Månsson, H. L. Lactoferrin and Cancer Disease Prevention. Crit. Rev. Food Sci. Nutr. 2008, 49, 203–217. DOI: 10.1080/10408390701856157.
   Web of Science ®Google Scholar
• Fernández‐Real, J. M.; García‐Fuentes, E.; Moreno‐Navarrete, J. M.; Murri‐Pierri, M.; Garrido‐Sánchez, L.; Ricart, W.; Tinahones, F. Fat Overload Induces Changes in Circulating Lactoferrin that are Associated with Postprandial Lipemia and Oxidative Stress in Severely Obese Subjects. Obesity. 2010, 18, 482–488. DOI: 10.1038/oby.2009.266.
   PubMed Web of Science ®Google Scholar
• Kim, J.; Ko, Y.; Park, Y.-K.; Kim, N.-I.; Ha, W.-K.; Cho, Y. Dietary Effect of Lactoferrin-enriched Fermented Milk on Skin Surface Lipid and Clinical Improvement of Acne Vulgaris. Nutrition. 2010, 26, 902–909. DOI: 10.1016/j.nut.2010.05.011.
   PubMed Web of Science ®Google Scholar
• Hill, K. E.; Malic, S.; McKee, R.; Rennison, T.; Harding, K. G.; Williams, D. W.; Thomas, D. W. An in Vitro Model of Chronic Wound Biofilms to Test Wound Dressings and Assess Antimicrobial Susceptibilities. J. Antimicrob. Chemother. 2010, 65, 1195–1206. DOI: 10.1093/jac/dkq105.
   PubMed Web of Science ®Google Scholar
• Ammons, M. C. B.; Ward, L. S.; Dowd, S.; James, G. A. Combined Treatment of Pseudomonas Aeruginosa Biofilm with Lactoferrin and Xylitol Inhibits the Ability of Bacteria to Respond to Damage Resulting from Lactoferrin Iron Chelation. Int. J. Antimicrob. Agents. 2011, 37, 316–323. DOI: 10.1016/j.ijantimicag.2010.12.019.
   PubMed Web of Science ®Google Scholar
• Ammons, M. C. B.; Ward, L. S.; James, G. A. Anti‐biofilm Efficacy of a Lactoferrin/xylitol Wound Hydrogel Used in Combination with Silver Wound Dressings. Int. Wound J. 2011, 8, 268–273. DOI:10.1111/j.1742-481X.2011.00781.x.
   PubMed Web of Science ®Google Scholar
• Tang, L.; Cui, T.; Wu, J. J.; Liu‐Mares, W.; Huang, N.; Li, J. A Rice‐derived Recombinant Human Lactoferrin Stimulates Fibroblast Proliferation, Migration, and Sustains Cell Survival. Wound Repair Regener. 2010, 18, 123–131. DOI:10.1111/j.1524-475X.2009.00563.x.
   PubMed Web of Science ®Google Scholar
• Lyons, T. E.; Miller, M. S.; Serena, T.; Sheehan, P.; Lavery, L.; Kirsner, R. S.; Armstrong, D. G.; Reese, A.; Yankee, E. W.; Veves, A. Talactoferrin Alfa, a Recombinant Human Lactoferrin Promotes Healing of Diabetic Neuropathic Ulcers: A Phase 1/2 Clinical Study. Am. J. Surg. 2007, 193(49–54). DOI:10.1016/j.amjsurg.2006.03.008.
   PubMedGoogle Scholar
• Atef Yekta, M.; Verdonck, F.; Van Den Broeck, W.; Goddeeris, B.; Cox, E.; Vanrompay, D. Lactoferrin Inhibits E. Coli O157: H7 Growth and Attachment to Intestinal Epithelial Cells. Vet. Med. 2010, 55, 359–368. DOI:10.17221/2954-VETMED.
   Web of Science ®Google Scholar
• Cerven, D.; DeGeorge, G.; Bethell, D. 28-day Repeated Dose Oral Toxicity of Recombinant Human Holo-lactoferrin in Rats. Regul. Toxicol. Pharmacol. 2008, 52(174–179). DOI:10.1016/j.yrtph.2008.06.006.
   PubMedGoogle Scholar