A review on Cosmos caudatus as A potential medicinal plant based on pharmacognosy, phytochemistry, and pharmacological activities

References

• Bunawan, H.; Baharum, S. N.; Bunawan, S. N.; Amin, N. M.; Noor, N. M. Cosmos Caudatus Kunth: A Traditional Medicinal Herb. Gjp. 2014, 8(3), 420–426.
   Google Scholar
• Cheng, S. H.; Ismail, A.; Anthony, J.; Ng, O. C.; Hamid, A. A.; Barakatun-Nisak, M. Y. Eight Weeks of Cosmos Caudatus (Ulam Raja) Supplementation Improves Glycemic Status in Patients with Type 2 Diabetes: A Randomized Controlled Trial. Evid. Based Complement. Alternat. Med. 2015, 1–7. DOI: 10.1155/2015/405615.
   Google Scholar
• Yosoff, N. A. H.; Sanuan, F. M.; Rukayadi, Y. Cosmos Caudatus Kunth. Extract Reduced Number of Microflora in Oyster Mushroom (Pleurotus Ostreatus). IFRJ. 2015, 22(5), 1837–1842.
   Web of Science ®Google Scholar
• Javadi, N.; Abas, F.; Mediani, A.; Hamid, A. A.; Khatib, A.; Simoh, S.; Shaari, K. Effect of Storage Time on Metabolite Profile and alpha-glucosidase Inhibitory Activity of Cosmos Caudatus leaves-GCMS Based Metabolomics Approach. JFDA. 2015, 23(3), 433–441. DOI: 10.1016/j.jfda.2015.01.005.
   Google Scholar
• Tandi, J.; Claresta, J. A.; Ayu, G.; Irwan, I. Effect of Ethanol Extract of Kenikir (Cosmos Caudatus Kunth.) Leaves in Blood Glucose, Cholesterol and Histopathology Pancreas of Male White Rats (Rattus Norvegicus). IJPST. 2018, 5(1), 1–7.
   Google Scholar
• Moshawih, S.; Cheema, M. S.; Ahmad, Z.; Zakaria, Z. A.; Hakim, M. N. A Comprehensive Review on Cosmos Caudatus (Ulam Raja): Pharmacology, Ethnopharmacology, and Phytochemistry. IRJES. 2017b, 1(1), 14–31.
   Google Scholar
• Lee, T. K.; Vairappan, C. S. Antioxidant, Antibacterial and Cytotoxic Activities of Essential Oils and Ethanol Extracts of Selected South East Asian Herbs. J. Med. Plant Res. 2011, 5(21), 5284–5290.
   Google Scholar
• Nurhayati, B.; Rahayu, I. G.; Rinaldi, S. F.; Zaini, W. S.; Afifah, E.; Arumwardana, S.; Kusuma, H. S. W.; Rizal,; Widowati, W.; Rizal, R. The Antioxidant and Cytotoxic Effects of Cosmos Caudatus Ethanolic Extract on Cervical Cancer. Indones Biomed. J. 2018, 10(3), 243–249. DOI: 10.18585/inabj.v10i3.441.
   Web of Science ®Google Scholar
• Andarwulan, N.; Batari, R.; Sandrasari, D. A.; Bolling, B.; Wijaya, H. Flavonoid Content and Antioxidant Activity of Vegetables from Indonesia. Foodchem. 2010, 121(4), 1231–1235.
   Google Scholar
• Rasdi, N. H. M.; Abd. Samah, O.; Sule, A.; Ahmed, Q. U. Antimicrobial Studies of Cosmos Caudatus Kunth. (Compositae). JMPR. 2010, 4(8), 669–673.
   Google Scholar
• Chan, E. W. C.; Wong, S. K.; Chan, H. T. Ulam Herbs of Oenanthe Javanica and Cosmos Caudatus: An Overview on Their Medicinal Properties. JNR. 2016, 16(4), 137–147. DOI: 10.18311/jnr/2016/8370.
   Google Scholar
• Sukarso, S.; Fidrany, I.; Anggadireja, K.; Handayani, W. A.; Anam, K. Influence of Drying Method on Flavonoid Content of Cosmos Caudatus (Kunth) Leaves. Rjmp. 2011, 5, 189–195.
   Google Scholar
• Wiart, C.;. Medicinal Plants in Asia for Metabolic Syndrome: Natural Products and Molecular Basis; CRC press Taylor and Francis Group: Boca Raton London New York, 2018.
   Google Scholar
• Quattrocchi, U.;. CRC World Dictionary of Medicinal and Poisonous Plants: Common Names, Scientific Names, Eponyms, Synonyms, and Etymology; CRC Press, Taylor and Francis Group: Boca Raton London New York. Page, 2012; pp 1149.
   Google Scholar
• Cheng, S. H.; Khoo, H. E.; Ismail, A.; Abdul-Hamid, A.; Barakatun-Nisak, M. Y. Influence of Extraction Solvents on Cosmos Caudatus Leaf Antioxidant Properties. Iran. J. Sci. Technol. Trans. A: Sci. 2016, 40(1), 51–58.
   Google Scholar
• Salamah, A.; Oktarina, R.; Ambarwati, E. A.; Putri, D. F.; Dwiranti, A.; Andayani, Chromosome Numbers of Some Asteraceae Species from Universitas Indonesia Campus, Depok, Indonesia,Biodiv. 2018, 19(6), 2079–2087.
   Google Scholar
• Seyedreihani, S. F.; Tan, T.-C.; Alkarkhi, A. F. M.; Easa, A. M. Total Phenolic Content and Antioxidant Activity of Ulam Raja (Cosmos Caudatus) and Quantification of Its Selected Marker Compounds: Effect of Extraction. Int. J. Food Prop. 2016, 20(2), 260–270. DOI: 10.1080/10942912.2016.1155055.
   Web of Science ®Google Scholar
• Ragasa, C. Y.; Nacpil, Z. D.; Penalosa, B. A.; Coll, J. C.; Rideout, J. A. Antimutagen and Antifungal Conpounds from Cosmos Caudatus. Philipp. J. Sci. 1997, 126(3), 199–206.
   Google Scholar
• Cheng, S. H.; Barakatun-Nisak, M. Y.; Anthony, J.; Ismail, A. Potential Medicinal Benefits of Cosmos Caudatus (Ulam Raja): A Scoping Review. J. Res. Med. Sci. 2015a, 20(10), 1000–1006. DOI: 10.4103/1735-1995.172796.
   PubMed Web of Science ®Google Scholar
• Mohd Bukhari, D. A.; Siddiqui, M. J.; Shamsudin, S. H.; Rahman, M. M.; Z, S. S. α-Glucosidase Inhibitory Activity of Selected Malaysian Plants. J. Pharm. Bioall. Sci. 2017, 9(3), 164–170. DOI: 10.4103/jpbs.JPBS_35_17.
   PubMed Web of Science ®Google Scholar
• Mediani, A.; Abas, F.; Khatib, A.; Tan, C. P. Cosmos Caudatus as a Potential Source of Polyphenolic Compounds: Optimisation of Oven Drying Conditions and Characterisation of Its Functional Properties. Molecules. 2013, 18(9), 10452–10464. DOI: 10.3390/molecules180910452.
   PubMed Web of Science ®Google Scholar
• Wan-Nadilah, W. A.; Akhtar, M. T.; Shaari, K.; Khatib, A.; Hamid, A. A.; Hamid, M. Variation in the Metabolites and α-glucosidase Inhibitory Activity of Cosmos Caudatus at Different Growth Stages. BMC Complement. Altern. Med. 2019, 19(1), 1–15. DOI: 10.1186/s12906-019-2655-9.
   PubMed Web of Science ®Google Scholar
• Javadi, N.; Abas, F.; Hamid, A. A.; Simoh, S.; Shaari, K.; Ismail, I. S.; Mediani, A.; Khatib, A. GC-MS-based Metabolite Profiling of Cosmos Caudatus Leaves Possessing alpha-glucosidase Inhibitory Activity. J. Food Sci. 2014, 79(6), C1130–C1136. DOI: 10.1111/1750-3841.12491.
   PubMed Web of Science ®Google Scholar
• Shui, G.; Leong, L. P.; Wong, S. P. Rapid Screening and Characterisation of Antioxidants of Cosmos Caudatus Using Liquid Chromatography Coupled with Mass Spectrometry. J. Chromb. 2005, 827(1), 127–138. DOI: 10.1016/j.jchromb.2005.07.029.
   PubMed Web of Science ®Google Scholar
• Hussin, M.; Abdul Hamid, A.; Abas, F.; Ramli, N. S.; Jaafar, A. H.; Roowi, S.; Majid, N. A.; Pak Dek, M. S. NMR-based Metabolomics Profiling for Radical Scavenging and anti-aging Properties of Selected Herbs. Molecules. 2019, 24(17), 3208. DOI: 10.3390/molecules24173208.
   PubMed Web of Science ®Google Scholar
• Fuzzati, N.; Sutarjadi, Dyatmiko, W.; Rahman, A.; Hostettmann, K. Phenylpropane Derivatives from Roots of Cosmos Caudatus. Phytochemistry. 1995, 39(2), 409–412. DOI: 10.1016/0031-9422(95)00031-2.
   Web of Science ®Google Scholar
• Wan-Nadilah, W. A.; Khozirah, S.; Khatib, A.; Hamid, A. A.; Hamid, M. Evaluation of the α-glucosidase Inhibitory and Free Radical Scavenging Activities of Selected Traditional Medicine Plant Species Used in Treating Diabetes. IFRJ. 2019, 26(1), 75–85.
   Web of Science ®Google Scholar
• Amalia, L.; Anggadireja, K.; Sukrasno, Fidrianny, I.; Inggriani, R. Antihypertensive Potency of Wild Cosmos (Cosmos Caudatus Kunth, Asteraceae) Leaf Extract. JPT. 2012, 7(8), 359–368.
   Google Scholar
• Rahman, H. A.; Saari, N.; Abas, F.; Ismail, A.; Mumtaz, M. W.; Hamid , A. A. Anti-obesity and antioxidant activities of selected medicinal plants and phytochemical profiling of bioactive compounds. Int. J. Food Prop. 2017a, 20(11), 2616–2629.
   Web of Science ®Google Scholar
• Abdullah, A.; Dhaliwal, K. K.; Roslan, N. N. F; Lee, C. H., Kalaiselvam, M., Radman, H. M., Saad, Q. H. M., Jaarin, K. The Effects of Cosmos Caudatus (Ulam Raja) on Detoxifying Enzymes in Extrahepatic Organs in Mice. J. App. Pharm. Sci. 2015, 5(1), 2616–2629.
   Google Scholar
• Dian-Nashiela, F.; Noriham, A.; Nooraain, H.; Azizah, A. A. Antioxidant activity of herbal tea prepared from Cosmos caudatus leaves at different maturity stages. IFRJ 2015, 22(3), 1189–1194. DOI:.
   Web of Science ®Google Scholar
• Mohamed, A.; Sahhugi, K. K.; Ramli, N. N. F.; Muhammad, C. H. The effects of Cosmos caudatus (ulam raja) on dynamic and cellular bone histomorphometry in ovariectomized rats. BMC Res. Notes 2013, 6(1), 239.
   PubMedGoogle Scholar
• Mohamed, N.; Khee, S. G. S.; Shuid, A. N.; Muhammad, N.; Suhaimi, F.; Othman, F.; Babji, A. S.; Soelaiman, I. N. The Effects of Cosmos Caudatus on Structural Bone Histomorphometry in Ovariectomized Rats. Evid. Based Complement. Alternat. Med. 2012, 2012, 1–6. DOI: 10.1155/2012/817814.
   Web of Science ®Google Scholar
• Perumal, V.; Hamid, A. A; Ismail, A.; Saari, N.; Abas, F.; Ismail, I.; Maulidiani, Lajis, N. H, Khatib, A. Effect of Cosmos Caudatus Kunth leaves on the lipid profile of A hyperlipidemia-Induced animal model. J. Food Chem. Nutr. 2014, 02(1), 43–51. DOI: .
   Google Scholar
• Sandhiutami, N. M. D.; Desmiaty, Y.; Noviyanti. Inhibitory Effect of Lantana camara L., Eclipta prostrata (L.) L. and Cosmos caudatus Kunth. leaf extracts on ADP-induced platelet aggregation. Pharmacog J. 2018, 10(3), 581–5.
   Google Scholar
• Ajaykumar, T. V.; Anandarajagopal, K.; Sunilson, J. A. J.; Ar`shad, A.; Jainaf, R. A. M.; Venkateshan, H. Anti-inflammation activity of Cosmos Caudatus. IJUPBS. 2012, 1(2), 40–48.
   Google Scholar
• Daud, D.; Azahar, A.; Abidin, S. S. F. Z., Tawang, A., Ross, E. E. R., Hashim, N. Comparative effects of Cosmos caudatus and Piper sarmentosum aqueous extracts on estrous cycle and fertility in female mice. J Pharm Adv Res. 2018, 1 7 , 346–351.
   Google Scholar
• Kerner, W.; Brückel, J. Definition, Classification and Diagnosis of Diabetes Mellitus. Exp. Clin. Endocrinol. Diabetes. 2014, 122(7), 384–386. DOI: 10.1055/s-0034-1366278.
   PubMed Web of Science ®Google Scholar
• Baynes, H. W. Classification, Pathophysiology, Diagnosis and Management of Diabetes Mellitus. J. Diabetes. Metab. 2015, 6(5), 1–9.
   Web of Science ®Google Scholar
• Jabir, K. V.; Jayalakshmi, B.; Hashim, K. M. In-vitro Anti Diabetic Studies and Phytochemical Evaluation of Heracleum Candolleanum. Asian J. Plant Sci. Res. 2014, 4(4), 31–36.
   Google Scholar
• Loh, S. P.; Hadira, O. In Vitro Inhibitory Potential of Selected Malaysian Plants against Key Enzymes Involved in Hyperglycemia and Hypertension. Malays. J. Nutr. 2011, 17(1), 77–86.
   PubMedGoogle Scholar
• Cheng, S. H.; Ismail, A.; Anthony, J.; Ng, O. C.; Hamid, A. A.; Yusof, B. N. M. Effect of Cosmos Caudatus (Ulam Raja) Supplementation in Patients with Type 2 Diabetes: Study Protocol for a Randomized Controlled Trial. BMC Complement. Altern. Med. 2016, 16(1), 1–8. DOI: 10.1186/s12906-016-1047-7.
   PubMedGoogle Scholar
• Salehan, N. M.; Meon, S.; Ismail, I. S. Antifungal Activity of Cosmos Caudatus Extracts against Seven Economically Important Plant Pathogens. Int. J. Agric. Biol. 2013, 15, 864–870.
   Web of Science ®Google Scholar
• Ayoub, Z.; Mehta, A. Medicinal Plants as Potential Souece of Antioxidant Agents: A Review. AJPCR. 2018, 11(6), 50–56.
   Google Scholar
• Chirag, J. P.; Tyagi, S.; Halligudi, N.; Yadav, J.; Pathak, S.; Singh, S. P.; Pandey, A.; Kamboj, D. S.; Shankar, P. Antioxidant Activity of Herbal Plants: A Recent Review. Jddt. 2013, 1(8), 1–8.
   Google Scholar
• Moshawih, S.; Cheema, M. S.; Ibraheem, Z. O.; Tailan, N. D., Hakim, M. N. Cosmos caudatus extract/fractions reduce smooth muscle cells migration and invasion in vitro: A potential benefit of suppressing atherosclerosis. PJB. 2017a, 2(6), 293–300 .
   Google Scholar
• Godspower, P. R.; Mohamed, N.; Shuid, A. N. Cosmos Caudatus Enhances Fracture Healing in Ovariectomised Rats: A Preliminary Biomechanical Evaluation. Int. J. Appl. Res. Nat. Prod. 2015, 8(1), 12–19.
   Google Scholar
• Mohamed, N.; Yin, C. M.; Shuid, A. N.; Muhammad, N.; Babji, A. S.; Soelaiman, I. N. The Effects of Cosmos Caudatus (Ulam Raja) Supplementation on Bone Biochemical Parameters in Ovariectomized Rats. Pak. J. Pharm. Sci. 2013b, 26(5), 1027–1031.
   PubMed Web of Science ®Google Scholar
• Rahman, H. A.; Sahib, N. G.; Saari, N., Abas, F., Ismail, A., Mumtaz, M. W., Hamid, A. A. Anti-obesity effect of ethanolic extract from Cosmos caudatus Kunth leaf in lean rats fed a high fat diet. BMC Complement Altern Med 2017b, 17(1), 1–17.
   PubMedGoogle Scholar
• Khan, F. S.; Akram, M.; Aslam, N.; Zaheer, J.; Mustafa, S. B.; Kausar, S.; Khan, A. H.; Khan, I. A.; Munir, N.; Ali Shah, S. M., et al. Phytochemical Analysis and Hepatoprotective Effect of Polyherbal Formulation on CCl4 Induced Hepatotoxicity in Mice. Pak. J. Pharm. Sci. 2018, 31(6(Suppl), 2719–2723.
   PubMed Web of Science ®Google Scholar
• Sarpin, N.; Daud, D.; Hashim, S. N. Comparative effects of Cosmos caudatus, Piper sarmentosum and Premna cordifolia ethanolic extracts on mice (Mus musculus) sperm parameters. Malays Appl Biol 2017, 46, 9–14.
   Google Scholar
• Booh, M. J.; Hashim, H.; Ismail, H. H.; Daud, D.; Samsulrizal, N.; Yahya, M. F. Z. R. Effects of Cosmos Caudatus on Sperm Quality of Mice, Mus Musculus. Malays. Appl. Biol. 2015, 44(1), 89–93.
   Google Scholar
• Daud, D.; Fekery, N. F. M.; Hashim, N. Reproductive Health of Rats with Benign Prostatic Hyperplasia following Cosmos Caudatus Ethanolic Extract Consumption. J. App. Pharm. Sci. 2017, 7(6), 202–205.
   Google Scholar
• Dwira, S.; Fadhillah, M. R.; Fadilah, F.; Azizah, N. N.; Putrianingsih, R.; Kusmardi, K. Cytotoxic Activity of Ethanol and Ethyl Acetate Extract of Kenikir (Cosmos Caudatus) against Cervical Cancer Cell Line (HELA). Research J. Pharm. Technol. 2019, 12(3), 1225–1229. DOI: 10.5958/0974-360X.2019.00203.8.
   Google Scholar
• Colares, A. V.; Almeida-Souza, F.; Taniwaki, N. N.; Souza, C. D. S. F.; da Costa, J. G. M.; Calabrese, K. D. S.; Abreu-Silva, A. L. In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis Arborea (Asteraceae) Baker. Evid. Based Complement. Alternat. Med. 2013, 2013, 1–7. DOI: 10.1155/2013/727042.
   Web of Science ®Google Scholar
• Topçu, G.; Gören, A. C. Bological Activity of Diterpenoids Isolated from Anatolia Lamiaceae Plants, Rec. Nat. Prod. 2007, 1(1), 1–16.
   Google Scholar
• Thakur, R.; Jain, N.; Pathak, R.; Sandhu, S. S. Practices in Wound Healing Studies of Plants. Evid. Based Complement. Alternat. Med. 2011:438056, 2011, 1–17 doi:10.1155/2011/438056.
   Web of Science ®Google Scholar
• Nawi, L.; Musa, N. L. W.; Zain, W. Z. W. M.; Kassim, J.; Karim, S. A. Premilinary Studies on Phytochemical Screening of Ulam and Fruit from Malaysia. E- J. Chem. 2011, 8(s1), S285–S288. DOI: 10.1155/2011/464595.
   Google Scholar
• Salim, R. J. M.; Krishnasamy, G.; Adenan, M. I.; Norhayati, I.; Jauri, M. H.; Sain, A. A. In Vitro anti-leismanial Activity of Malaysian Medicinal and Forest Plant Species. JTFS. 2018, 30(2), 234–241. DOI: 10.26525/jtfs2018.30.2.234241.
   Web of Science ®Google Scholar
• Norazlina, M.; Ehsan, S. Z.; Adilah, K. N.; Lee, C. P.; Farhana, E.; Derick, P.; Nirwana, S. I.; Nazrun, A. S.; Norliza, M. Acute Toxicity Study of Cosmos Caudatus on Biochemical Parameters in Male Rats. Sains Malays. 2013, 42(9), 1247–1251.
   Web of Science ®Google Scholar
• Rameli, N. M.; Kader, M. A.; Aznan, A. S.; Musa, N. Effect of Cosmos Caudatus Extract on Antibacterial Activity and Lethality Activity of Brine Shrimp. AACL Bioflux. 2018, 11(3), 606–612.
   Google Scholar
• Sharwan, G.; Jain, P.; Pandey, R.; Shukla, S. S. Toxicity Profile of Traditional Herbal Medicine. Int. J. Ayurvedic Herb. Med. 2015, 1(3), 81–90. DOI: 10.31254/jahm.2015.1306.
   Google Scholar