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Review

Phytochemical profile and pro-healthy properties of Terminalia chebula: A comprehensive review

, , , , ORCID Icon, , , ORCID Icon, ORCID Icon, ORCID Icon, , & ORCID Icon show all
Pages 526-551 | Received 03 Oct 2022, Accepted 05 Jan 2023, Published online: 31 Jan 2023

References

  • Martinez-Mayorga, K.; Madariaga-Mazon, A.; Medina-Franco, J. L.; Maggiora, G. The Impact of Chemoinformatics on Drug Discovery in the Pharmaceutical Industry. Expert Opin. Drug Discov. 2020, 15(3), 293–306. DOI: 10.1080/17460441.2020.1696307.
  • Kiio, T. M.; Park, S. Nano-scientific Application of Atomic Force Microscopy in Pathology: From Molecules to Tissues. Int. J. Medical Sci. 2020, 17(7), 844. DOI: 10.7150/ijms.41805.
  • Gyawali, B.; Khanal, P.; Mishra, S. R.; van Teijlingen, E.; Wolf Meyrowitsch, D. Building Strong Primary Health Care to Tackle the Growing Burden of non-communicable Diseases in Nepal. Glob. Health Action. 2020, 13(1), 1788262. DOI: 10.1080/16549716.2020.1788262.
  • Mozaffarian, D.; Rosenberg, I.; Uauy, R. History of Modern Nutrition science—implications for Current Research, Dietary Guidelines, and Food Policy. Bmj. 2018, 361. DOI: 10.1136/bmj.k2392.
  • Gómez, M.; Martinez, M. M. Fruit and Vegetable by-products as Novel Ingredients to Improve the Nutritional Quality of Baked Goods. Crit. Rev. Food Sci. Nutr. 2018, 58(13), 2119–2135. DOI: 10.1080/10408398.2017.1305946.
  • Mohotti, S.; Rajendran, S.; Muhammad, T.; Strömstedt, A. A.; Adhikari, A.; Burman, R.; Gunasekera, S. Screening for Bioactive Secondary Metabolites in Sri Lankan Medicinal Plants by Microfractionation and Targeted Isolation of Antimicrobial Flavonoids from Derris Scandens. J. Ethnopharmacol. 2020, 246, 112158. DOI: 10.1016/j.jep.2019.112158.
  • Singh, R. Chemotaxonomy: A Tool for Plant Classification. J. Med. Plants Stud. 2016, 4(2), 90–93.
  • Gunasekar, C. J.; Abu-Yousef, I.; Majdalawieh, A.; Narasimhan, S. Pharmacognostic Evaluation of Terminalia Chebula Standard Extracts and Finished Products. Mediterranean Journal of Chemistry. 2019, 8(6), 441–452. DOI: 10.13171/mjc861907177afm.
  • Carrubba, A.; Scalenghe, R. The Scent of Mare Nostrum: Medicinal and Aromatic Plants in Mediterranean Soils. J. Sci. Food Agric. 2012, 92(6), 1150–1170. DOI: 10.1002/jsfa.5630.
  • Awuchi, C. G. Medicinal Plants: The Medical, Food, and Nutritional Biochemistry and Uses. Int. J. Adv. Acad. Res. 2019, 5(11), 220–241.
  • Ahn, K. The Worldwide Trend of Using Botanical Drugs and Strategies for Developing Global Drugs. BMB Rep. 2017, 50(3), 111. DOI: 10.5483/BMBRep.2017.50.3.221.
  • Smith-Hall, C.; Larsen, H. O.; Pouliot, M. People, Plants and Health: A Conceptual Framework for Assessing Changes in Medicinal Plant Consumption. J. Ethnobiol. Ethnomed. 2012, 8(1), 1–11. DOI: 10.1186/1746-4269-8-43.
  • Cock, I. E. The Medicinal Properties and Phytochemistry of Plants of the Genus Terminalia (Combretaceae). Inflammopharmacology. 2015, 23(5), 203–229. DOI: 10.1007/s10787-015-0246-z.
  • Akbar, S.;. Terminalia Chebula Retz. (Combretaceae). In Handbook of 200 Medicinal Plants; Springer: Cham, 2020; pp 1779–1793. DOI: 10.1007/978-3-030-16807-0.
  • Zhao, L.; Duan, Z.; Wang, Y.; Wang, M.; Liu, Y.; Wang, X.; Li, H. Protective Effect of Terminalia Chebula Retz. Extract against Aβ Aggregation and Aβ-induced Toxicity in Caenorhabditis Elegans. J. Ethnopharmacol. 2021, 268, 113640. DOI: 10.1016/j.jep.2020.113640.
  • Meher, S. K.; Panda, P.; Das, B.; Bhuyan, G. C.; Rath, K. K. Pharmacological Profile of Terminalia Chebula Retz. and Willd. (Haritaki) in Ayurveda with Evidences. Res. J. Pharmacol. Pharmacodyn. 2018, 10(3), 115–124. DOI: 10.5958/2321-5836.2018.00023.X.
  • Afshari, A. R.; Sadeghnia, H. R.; Mollazadeh, H. A Review on Potential Mechanisms of Terminalia Chebula in Alzheimer’s Disease. Adv. Pharmacol. Sci. 2016, 2016, 8964849. DOI: 10.1155/2016/8964849.
  • Bhatt, I. D.; Rawat, S.; Badhani, A.; Rawal, R. S. Nutraceutical Potential of Selected Wild Edible Fruits of the Indian Himalayan Region. Food Chem. 2017, 215, 84–91. DOI: 10.1016/j.foodchem.2016.07.143.
  • Akhtar, H.; Husain, S. Z.; Descriptive, A. Review on Traditional Herbal Drug-Terminalia Chebula. J. Adv. Res. Biochem. Pharmacol. 2019, 2(1), 21–28.
  • RAI, A. K.; Joshi, R. Evaluation of Antimicrobial Properties of Fruit Extracts of Terminalia Chebula against Dental Caries Pathogens. Jundishapur J. Microbiol. 2009, 2, 105–111.
  • Ashwini, R.; Gajalakshmi, S.; Mythili, S.; Sathiavelu, A. Terminalia chebula-a Pharmacological Review. J. Pharm. Res. 2011, 4(9), 2884–2887.
  • Gupta, P. C. Biological and Pharmacological Properties of Terminalia Chebula Retz. (Haritaki)-an Overview. Int. J. Pharm. Pharm. Sci. 2012, 4(3), 62–68.
  • Eqbal, F. Majoon Halaila: A Potential Compound Formulation to Counter Premature Ageing-A Review. J. drug deliv. Ther. 2022, 12(2–S), 178–184. DOI: 10.22270/jddt.v12i2-S.5427.
  • Tabasum, H.; Ahmad, T. Principles and Short Practice of Cosmetic Care in Unani Medicine; India: Educreation Publishing, 2018.
  • Malik, T.; Madan, V. K.; Dhanda, T. Assessment of Medicinal Plants through Proximate and Micronutrients Analysis. J. plant dev. Sci. 2020, 12(4), 223–229.
  • Chakradhari, S.; Martín Ramos, P.; Patel, K. S.; Towett, E. K.; Martín Gil, J.; Rajhans, K. P. Nutritional and Spectral Characteristics of Terminalia Plants. Eur. J Med Plants. 2019, 27(4), 1–13. DOI: 10.9734/ejmp/2019/v27i430120.
  • Surveswaran, S.; Cai, Y. Z.; Corke, H.; Sun, M. Systematic Evaluation of Natural Phenolic Antioxidants from 133 Indian Medicinal Plants. Food Chem. 2007, 102(3), 938–953. DOI: 10.1016/j.foodchem.2006.06.033.
  • Juang, L. J.; Sheu, S. J.; Lin, T. C. Determination of Hydrolyzable Tannins in the Fruit of Terminalia Chebula Retz. by High‐performance Liquid Chromatography and Capillary Electrophoresis. J. Sep. Sci. 2004, 27(9), 718–724. DOI: 10.1002/jssc.200401741.
  • Han, Q.; Song, J.; Qiao, C.; Wong, L.; Xu, H. Preparative Isolation of Hydrolysable Tannins Chebulagic Acid and Chebulinic Acid from Terminalia Chebula by High‐speed Counter‐current Chromatography. J. Sep. Sci. 2006, 29(11), 1653–1657. DOI: 10.1002/jssc.200600089.
  • Ahmad, S.; Khan, A.; Batool, Z.; Mehmood, M. H.; Khaliq, S.; Tabassu, S.; Haider, S. Medicinal Effects of Saffron and Chamomile on Diabetes Mellitus and Associated Hyperlipidemia and Memory Impairment. Pak. J. Pharm. Sci. 2020, 33(3), 1191–1198.
  • Zhang, X.; Chen, C.; He, S. Supercritical-CO2, G. F. Fluid Extraction of the Fatty Oil in Terminalia Chebula and GC-MS Analysis. Zhong Yao Cai= Zhongyaocai= J. Chinese Medicinal Mat. 1997, 20(9), 463–464.
  • Bag, A.; Chattopadhyay, R. R. Efflux-pump Inhibitory Activity of a Gallotannin from Terminalia Chebula Fruit against multidrug-resistant Uropathogenic Escherichia Coli. Nat. Prod. Res. 2014, 28(16), 1280–1283. DOI: 10.1080/14786419.2014.895729.
  • Jokar, A.; Masoomi, F.; Sadeghpour, O.; Nassiri-Toosi, M.; Hamedi, S. Potential Therapeutic Applications for Terminalia Chebula in Iranian Traditional Medicine. J. Traditional Chin. Med. 2016, 36(2), 250–254. DOI: 10.1016/S0254-6272(16)30035-8.
  • Reddy, D. B.; Reddy, T. C. M.; Jyotsna, G.; Sharan, S.; Priya, N.; Lakshmipathi, V.; Reddanna, P. Chebulagic Acid, a COX–LOX Dual Inhibitor Isolated from the Fruits of Terminalia Chebula Retz., Induces Apoptosis in COLO-205 Cell Line. J. Ethnopharmacol. 2009, 124(3), 506–512. DOI: 10.1016/j.jep.2009.05.022.
  • Lee, H. S.; Koo, Y. C.; Suh, H. J.; Kim, K. Y.; Lee, K. W. Preventive Effects of Chebulic Acid Isolated from Terminalia Chebula on Advanced Glycation endproduct-induced Endothelial Cell Dysfunction. J. Ethnopharmacol. 2010, 131(3), 567–574. DOI: 10.1016/j.jep.2010.07.039.
  • Lee, D. Y.; Yang, H.; Kim, H. W.; Sung, S. H. New Polyhydroxytriterpenoid Derivatives from Fruits of Terminalia Chebula Retz. and Their α-glucosidase and α-amylase inhibitory activity. Bioorganic Med. Chem. Lett. 2017, 27(1), 34–39.
  • Gao, H.; Huang, Y. N.; Xu, P. Y.; Kawabata, J. Inhibitory effect on α-glucosidase by the fruits of Terminalia chebula Retz. Food Chem. 2007, 105(2), 628–634.
  • Tubtimdee, C.; Shotipruk, A. Extraction of Phenolics from Terminalia Chebula Retz with water–ethanol and water–propylene Glycol and sugaring-out Concentration of Extracts. Sep. Purif. Technol. 2011, 77(3), 339–346. DOI: 10.1016/j.seppur.2011.01.002.
  • Chattopadhyay, R. R.; Bhattacharyya, S. K.; Medda, C.; Chanda, S.; Datta, S.; Pal, N. K. Antibacterial Activity of Black Myrobalan (Fruit of Terminalia Chebula Retz.) against Uropathogen Escherichia Coli. Pharmacogn. Mag. 2007, 3(11), 212.
  • Mammen, D.; Bapat, S.; Sane, R. An Investigation to Variation in Constituents in the Fruits of Terminalia Chebula Retz. at Different Maturity Stages. Int. J. Pharm. Bio. Sci. 2012, 3(1), 416–419.
  • Nollet, L. M., and Gutierrez-Uribe, J. A., Eds. Phenolic Compounds in Food: Characterization and Analysis; New York, US: CRC Press, 2018.
  • Saleem, A.; Husheem, M.; Härkönen, P.; Pihlaja, K. Inhibition of Cancer Cell Growth by Crude Extract and the Phenolics of Terminalia Chebula Retz. Fruit. J. Ethnopharmacol. 2002, 81(3), 327–336. DOI: 10.1016/S0378-8741(02)00099-5.
  • Soni, S.; Sharma, H. K.; Kaushal, P.; Singh, C. Effect of Process Parameters on the Antioxidant Activities of Bioactive Compounds from Harad (Terminalia Chebula Retz.). Agric. Eng. Int. CIGR J. 2015, 17, 2.
  • Lopes, G. K.; Schulman, H. M.; Hermes-Lima, M. Polyphenol Tannic Acid Inhibits Hydroxyl Radical Formation from Fenton Reaction by Complexing Ferrous Ions. Biochim. Biophys. Acta Gen. Subj. 1999, 1472(1–2), 142–152. DOI: 10.1016/S0304-4165(99)00117-8.
  • Yoshida, T.; Amakura, Y.; Yoshimura, M. Structural Features and Biological Properties of Ellagitannins in Some Plant Families of the Order Myrtales. Int. J. Mol. Sci. 2010, 11(1), 79–106. DOI: 10.3390/ijms11010079.
  • Mueller-Harvey, I. Analysis of Hydrolysable Tannins. Anim. Feed Sci. Tech. 2001, 91(1–2), 3–20. DOI: 10.1016/S0377-8401(01)00227-9.
  • Lokeswari, N.; Raju, K. J. Optimization of Gallic Acid Production from Terminalia Chebula by Aspergillus Niger. E-J. Chem. 2007, 4(2), 287–293. DOI: 10.1155/2007/649306.
  • Venkatesan, A.; Kathirvel, A.; Prakash, S.; Sujatha, V. Antioxidant, Antibacterial Activities and Identification of Bioactive Compounds from Terminalia Chebula Bark Extracts. Free Radic. Antioxid. 2017, 7(1), 43–49. DOI: 10.5530/fra.2017.1.7.
  • Khan, M. U.; Khalilullah, H.; Akhtar, J. A. W. E. D.; Elhasan, G. O. Terminalia Chebula: An Ephemeral Glance. Int. J. Pharm. Pharmac. Sci. 2015, 7(2), 40–43.
  • Kumar, B. S.; Lakshman, K.; Jayaveera, K. N.; Krishna, N. V.; Manjunath, M.; Suresh, M. V.; Naik, S. Estimation of Rutin and Quercetin in Terminalia Chebula by HPLC. Asian J. Res. Chem. 2009, 2(4), 388–389.
  • Tariq, A. L.; Reyaz, A. L. Quantitative Phytochemical Analysis of Traditionally Used Medicinal Plant Terminalia Chebula. Int Res J Biotechnol. 2013, 4(5), 101–105.
  • Anil, M.; Nandini, P. Simultaneous Isolation and Identification of Phytoconstituents from Terminalia Chebula by Preparative Chromatography. J. Chem. Pharmaceut. Res. 2010, 2(5), 97–103.
  • Huang, D. J.; Hsien-Jung, C.; Chun-Der, L. I. N.; Yaw-Huei, L. I. N. Antioxidant and Antiproliferative Activities of Water Spinach (Ipomoea Aquatica Forsk) Constituents. Bot. Bull. Acad. Sin. 2005, 46, 99–106.
  • Bajpai, M.; Pande, A.; Tewari, S. K.; Prakash, D. Phenolic Contents and Antioxidant Activity of Some Food and Medicinal Plants. Int. J. Food Sci. Nutr. 2005, 56(4), 287–291. DOI: 10.1080/09637480500146606.
  • Cheng, H. Y.; Lin, T. C.; Yu, K. H.; Yang, C. M.; Lin, C. C. Antioxidant and Free Radical Scavenging Activities of Terminalia Chebula. Biol. Pharm. Bull. 2003, 26(9), 1331–1335. DOI: 10.1248/bpb.26.1331.
  • Moe, T. S.; Win, H. H.; Hlaing, T. T.; Lwin, W. W.; Htet, Z. M.; Mya, K. M. Evaluation of in Vitro Antioxidant, Antiglycation and Antimicrobial Potential of Indigenous Myanmar Medicinal Plants. J. Integr. Med. 2018, 16(5), 358–366. DOI: 10.1016/j.joim.2018.08.001.
  • Rajmohamed, M. A.; Natarajan, S.; Palanisamy, P.; Abdulkader, A. M.; Govindaraju, A. Antioxidant and Cholinesterase Inhibitory Activities of Ethyl Acetate Extract of Terminalia Chebula: Cell-free in Vitro and in Silico Studies. Pharmacogn. Mag. 2017, 13(Suppl 3), S437. DOI: 10.4103/pm.pm_57_17.
  • Chen, X.; Sun, F.; Ma, L.; Wang, J.; Qin, H.; Du, G. In Vitro Evaluation on the Antioxidant Capacity of Triethylchebulate, an Aglycone from Terminalia Chebula Retz Fruit. Indian J. Pharmacol. 2011, 43(3), 320. DOI: 10.4103/0253-7613.81508.
  • Saha, P. K.; Patrab, P. H.; Pradhan, R.; Radharaman Dey, S. D.; Mandal, T. K. V. Effect of Terminalia Belerica & Terminalia Chebula on Wound Healing in Induced Dermal Wounds in Rabbits. Pharmacologyonline. 2011, 2, 235–241.
  • Sheng, Z.; Zhao, J.; Muhammad, I.; Zhang, Y.; Lightfoot, D. A. Optimization of Total Phenolic Content from Terminalia Chebula Retz. Fruits Using Response Surface Methodology and Evaluation of Their Antioxidant Activities. PloS one. 2018, 13(8), e0202368. DOI: 10.1371/journal.pone.0202368.
  • Cui, E.; Zhi, X.; Chen, Y.; Gao, Y.; Fan, Y.; Zhang, W.; Song, X. Coptis Chinensis and Myrobalan (Terminalia Chebula) Can Synergistically Inhibit Inflammatory Response in Vitro and in Vivo. Evid.-based Complement. Altern. Med. 2014, 510157. DOI: 10.1155/2014/510157.
  • Ekambaram, S. P.; Perumal, S. S.; Erusappan, T.; Srinivasan, A. Hydrolysable tannin-rich Fraction from Terminalia Chebula Retz. Fruits Ameliorates collagen-induced Arthritis in BALB/c Mice. Inflammopharmacology. 2020, 28(1), 275–287. DOI: 10.1007/s10787-019-00629-x.
  • Rahimi, V. B.; Askari, V. R.; Shirazinia, R.; Soheili-Far, S.; Askari, N.; Rahmanian-Devin, P.; Ghodsi, R.; Mousavi, S. H.; Ghodsi, R. Protective Effects of hydro-ethanolic Extract of Terminalia Chebula on Primary Microglia Cells and Their Polarization (M1/M2 Balance). Mult. Scler. Relat. Disord. 2018, 25, 5–13. DOI: 10.1016/j.msard.2018.07.015.
  • Zhao, Y.; Liu, F.; Liu, Y.; Zhou, D.; Dai, Q.; Liu, S.; Ashour, H. M. Anti-arthritic Effect of Chebulanin on collagen-induced Arthritis in Mice. PLoS One. 2015, 10(9), e0139052. DOI: 10.1371/journal.pone.0139052.
  • Upadhyay, A.; Agrahari, P.; Singh, D. K. A Review on the Pharmacological Aspects of Terminalia Chebula. Int. J. Pharmacol. 2014, 10(6), 289–298. DOI: 10.3923/ijp.2014.289.298.
  • Nair, V.; Singh, S.; Gupta, Y. K. Anti-arthritic and Disease Modifying Activity of Terminalia Chebula Retz. in Experimental Models. J. Pharm. Pharmacol. 2010, 62(12), 1801–1806. DOI: 10.1111/j.2042-7158.2010.01193.x.
  • Yang, M. H.; Ali, Z.; Khan, I. A.; Khan, S. I. Anti-inflammatory Activity of Constituents Isolated from Terminalia Chebula. Nat. Prod. Commun. 2014, 9(7), 1934578X1400900721.
  • Shaikh, R. U.; Pund, M. M.; Gacche, R. N. Evaluation of anti-inflammatory Activity of Selected Medicinal Plants Used in Indian Traditional Medication System in Vitro as Well as in Vivo. J. Tradit. Complement. Med. 2016, 6(4), 355–361. DOI: 10.1016/j.jtcme.2015.07.001.
  • Kalaiselvan, S.; Rasool, M. K. The anti-inflammatory Effect of Triphala in arthritic-induced Rats. Pharm. Boil. 2016, 53(1), 51–60. DOI: 10.3109/13880209.2014.910237.
  • Seo, J. B.; Jeong, J. Y.; Park, J. Y.; Jun, E. M.; Lee, S. I.; Choe, S. S.; Lee, T. G.; Choi, E.-W.; Seen, D.-S.; Lim, J.-S. Anti-arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia Chebula, on Arthritis and Pain Model. Biomol. Ther. 2012, 20(1), 104. DOI: 10.4062/biomolther.2012.20.1.104.
  • Karlapudi, V.; Prasad Mungara, A. V. V.; Sengupta, K.; Davis, B. A.; Raychaudhuri, S. P. A placebo-controlled double-blind Study Demonstrates the Clinical Efficacy of A Novel Herbal Formulation for Relieving Joint Discomfort in Human Subjects with Osteoarthritis of Knee. J. Med. Food. 2018, 21(5), 511–520. DOI: 10.1089/jmf.2017.0065.
  • Timbadiya, M. J.; Nishteswar, K.; Acharya, R.; Nariya, M. B. Experimental Evaluation of Antipyretic and Analgesic Activities of Amalakyadi Gana: An Ayurvedic Formulation. Ayu. 2015, 36(2), 220. DOI: 10.4103/0974-8520.175554.
  • Nanna, U.; Jaijoy, K.; Soonthornchareonnon, N.; Sireeratawong, S. Analgesic and Antipyretic Activity of Tri-Sa-Maw Recipe. J. Med. Assoc. Thai. 2015, 98(2), S16–S21.
  • Saha, M.; Kumar, M. B.; Singh, A. A. Review Article on Various Phytochemicals and Different Medicinal Activities of Haritaki. Lang. 2020, 5(6), 1432–1444. https://ijisrt.com/assets/upload/files/IJISRT20JUN742_(1).pdf
  • Nyinoh, I. W.; Atu, B. O.; Oluma, H. O. A. The Use of Medicinal Plants as Alternatives for Typhoid Fever and Bacterial Gastroenteritis Therapy in Abwa-Mbagen, Nigeria. European J. Med. Plants. 2018, 24(2), 1–12. DOI: 10.9734/EJMP/2018/42248.
  • Malckzadeh, F.; Ehsanifar, H.; Shahamat, N.; Levin, M.; Colwell, R. R. Antibacterial Activity of Black Myrobalan (Terminalia Chebula Retz.) against Helicobactor Pyroli. Int. J. Antimicrob Agent. 2001, 18(1), 85–88. DOI: 10.1016/S0924-8579(01)00352-1.
  • Mandeville, A.; Cock, I. E. Terminalia Chebula Retz. Fruit Extracts Inhibit Bacterial Triggers of Some Autoimmune Diseases and Potentiate the Activity of Tetracycline. Indian J. Microbio. 2018, 58(4), 496–506. DOI: 10.1007/s12088-018-0754-9.
  • Acharyya, S.; Sarkar, P.; Saha, D. R.; Patra, A.; Ramamurthy, T.; Bag, P. K. Intracellular and membrane-damaging Activities of Methyl Gallate Isolated from Terminalia Chebula against multidrug-resistant Shigella Spp. J. Med. Microbio. 2015, 64(8), 901–909. DOI: 10.1099/jmm.0.000107.
  • Kumari, R.; Mishra, R. C.; Yadav, A.; Yadav, J. P. Screening of Traditionally Used Medicinal Plants for Their Antimicrobial Efficacy against Oral Pathogens and GC-MS Analysis of Acacia Nilotica Extract. Indian J. Tradit. Knowl. 2019, 18(1), 162–168.
  • Velmurugan, A.; Madhubala, M. M.; Bhavani, S.; Kumar, K. S. S.; Sathyanarayana, S. S.; Gurucharan, N. An in-vivo Comparative Evaluation of Two Herbal Extracts Emblica Officinalis and Terminalia Chebula with Chlorhexidine as an Anticaries Agent: A Preliminary Study. J. Conservative Dent. 2013, 16(6), 546. DOI: 10.4103/0972-0707.120958.
  • Omran, Z.; Bader, A.; Porta, A.; Vandamme, T.; Anton, N.; Alehaideb, Z.; Halwani, M. Evaluation of Antimicrobial Activity of Triphala Constituents and Nanoformulation. Evid.-based Complement. Altern. Med. 2020, 2020, 6976973. DOI: 10.1155/2020/6976973.
  • Shanbhag, V, K. L. Triphala in Prevention of Dental Caries and as an Antimicrobial in Oral cavity-a Review. Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious Disorders). 2015, 15(2), 89–97.
  • Palit, M.; Hegde, S. K.; Bhat, S. S. Effectiveness of Mouthrinse Formulated from Aqueous Extract of Terminalia Chebula on Salivary Streptococcus Mutans Count and pH among 8-to 12-year-old School Children of Karnataka: A Randomized Clinical Trial. J. Clin. Pediatr. Dent. 2016, 9(4), 349. DOI: 10.5005/jp-journals-10005-1390.
  • Howshigan, J.; Perera, K.; Samita, S.; Rajapakse, P. S. The Effects of an Ayurvedic Medicinal Toothpaste on Clinical, Microbiological and Oral Hygiene Parameters in Patients with Chronic Gingivitis: A double-blind, Randomised, placebo-controlled, Parallel Allocation Clinical Trial. Ceylon Med. J. 2015, 60(4), 126–132. DOI: 10.4038/cmj.v60i4.8219.
  • Dutta, B. K.; Rahman, I.; Das, T. K. Antifungal Activity of Indian Plant Extracts: Antimyzetische Aktivität Indischer Pflanzenextrakte. Mycoses. 1998, 41(11‐12), 535–536. DOI: 10.1111/j.1439-0507.1998.tb00718.x.
  • Bonjar, G. S. Inhibition of Clotrimazole-resistant Candida Albicans by Plants Used in Iranian Folkloric Medicine. Fitoterapia. 2004, 75(1), 74–76. DOI: 10.1016/j.fitote.2003.08.012.
  • Upadhyay, A.; Singh, D. K. Molluscicidal Activity of Sapindus Mukorossi and Terminalia Chebula against the Freshwater Snail Lymnaea Acuminata. Chemosphere. 2011, 83(4), 468–474. DOI: 10.1016/j.chemosphere.2010.12.066.
  • Venkatesalu, V.; Gopalan, N.; Pillai, C. R.; Singh, V.; Chandrasekaran, M.; Senthilkumar, A.; Chandramouli, N. In Vitro anti-plasmodial Activity of Some Traditionally Used Medicinal Plants against Plasmodium Falciparum. Parasitol. Res. 2012, 111(1), 497–501. DOI: 10.1007/s00436-012-2834-9.
  • Sharma, S.; Singh, B.; Kumar, H. A Critical Review of Pharmacological Actions of Haritaki (Terminalia Chebula Retz) in Classical Texts. J. Ayurveda Integr. Med. Sci. 2019, 4(4), 258–269.
  • Badmaev, V.; Nowakowski, M. Protection of Epithelial Cells against Influenza A Virus by A Plant Derived Biological Response Modifier Ledretan‐96. Phytother. Res. 2000, 14(4), 245–249. DOI: 10.1002/1099-1573(200006)14:4<245::AID-PTR571>3.0.CO;2-O.
  • Kesharwani, A.; Polachira, S. K.; Nair, R.; Agarwal, A.; Mishra, N. N.; Gupta, S. K. Anti-HSV-2 Activity of Terminalia Chebula Retz Extract and Its Constituents, Chebulagic and Chebulinic Acids. BMC Complement. Altern. Med. 2017, 17(1), 1–11. DOI: 10.1186/s12906-017-1620-8.
  • Ajala, O. S.; Jukov, A.; Ma, C. M. Hepatitis C Virus Inhibitory Hydrolysable Tannins from the Fruits of Terminalia Chebula. Fitoterapia. 2014, 99, 117–123. DOI: 10.1016/j.fitote.2014.09.014.
  • Oyuntsetseg, N.; Khasnatinov, M. A.; Molor-Erdene, P.; Oyunbileg, J.; Liapunov, A. V.; Danchinova, G. A.; Chimedragchaa, C.; Baigalmaa, J.; Chimedragchaa, C. Evaluation of Direct Antiviral Activity of the Deva-5 Herb Formulation and Extracts of Five Asian Plants against Influenza A Virus H3N8. BMC Complement. Altern. Med. 2014, 14(1), 1–9. DOI: 10.1186/1472-6882-14-235.
  • Lin, L. T.; Chen, T. Y.; Chung, C. Y.; Noyce, R. S.; Grindley, T. B.; McCormick, C.; Richardson, C. D. Hydrolyzable Tannins (Chebulagic Acid and Punicalagin) Target Viral glycoprotein-glycosaminoglycan Interactions to Inhibit Herpes Simplex Virus 1 Entry and cell-to-cell Spread. J. viro. 2011, 85(9), 4386–4398. DOI: 10.1128/JVI.01492-10.
  • Kim, T. G.; Kang, S. Y.; Jung, K. K.; Kang, J. H.; Lee, E.; Han, H. M.; Kim, S. H. Antiviral Activities of Extracts Isolated from Terminalis Chebula Retz., Sanguisorba Officinalis L., Rubus Coreanus Miq. and Rheum Palmatum L. against Hepatitis B Virus. Phytotherapy Res. 2001, 15(8), 718–720. DOI: 10.1002/ptr.832.
  • Raghuvanshi, D.; Dhalaria, R.; Sharma, A.; Kumar, D.; Kumar, H.; Valis, M.; Puri, S.; Verma, R.; Puri, S. Ethnomedicinal Plants Traditionally Used for the Treatment of Jaundice (Icterus) in Himachal Pradesh in Western Himalaya—a Review. Plants. 2021, 10(2), 232. DOI: 10.3390/plants10020232.
  • Ahmed, S.; Ding, X.; Sharma, A. Exploring Scientific Validation of Triphala Rasayana in Ayurveda as a Source of Rejuvenation for Contemporary Healthcare: An Update. J. Ethnopharm. 2021, 273, 113829. DOI: 10.1016/j.jep.2021.113829.
  • Tamhane, M. D.; Thorat, S. P.; Rege, N. N.; Dahanukar, S. A. Effect of Oral Administration of Terminalia Chebula on Gastric Emptying: An Experimental Study. J. Postgraduate Med. 1997, 43(1), 12.
  • Raju, D.; Ilango, K.; Chitra, V.; Ashish, K. Evaluation of Anti-ulcer Activity of Methanolic Extract of Terminalia Chebula Fruits in Experimental Rats. J. Pharm. Sci. Res. 2009, 1(3), 101.
  • Mishra, V.; Agrawal, M.; Onasanwo, S. A.; Madhur, G.; Rastogi, P.; Pandey, H. P.; Narender, T.; Narender, T. Anti-secretory and cyto-protective Effects of Chebulinic Acid Isolated from the Fruits of Terminalia Chebula on Gastric Ulcers. Phytomedicine. 2013, 20(6), 506–511. DOI: 10.1016/j.phymed.2013.01.002.
  • Sheng, Z.; Yan, X.; Zhang, R.; Ni, H.; Cui, Y.; Ge, J.; Shan, A. Assessment of the Antidiarrhoeal Properties of the Aqueous Extract and Its Soluble Fractions of Chebulae Fructus (Terminalia Chebula Fruits). Pharmaceut. Bio. 2016, 54(9), 1847–1856. DOI: 10.3109/13880209.2015.1131993.
  • Wannasiri, S.; Jaijoy, K.; Chiranthanut, N.; Soonthornchareonnon, N.; Sireeratawong, S. Effect of Tri-Sa-Maw Recipe on Gastrointestinal Regulation and Motility. J. Med. Assoc. Thai. 2015, 98(2), S1–S7.
  • Lee, J.; Choi, H. S.; Lee, J.; Park, J.; Kim, S. B.; Shin, M. S.; Kang, K. S.; Hwang, G. S.; Koo, B. A.; Kang, K. S. Preparation of Herbal Formulation for Inflammatory Bowel Disease Based on in Vitro Screening and in Vivo Evaluation in a Mouse Model of Experimental Colitis. Molecules. 2019, 24(3), 464. DOI: 10.3390/molecules24030464.
  • Patel, A. G.; Patel, M. R.; Nariya, M. B. Assessment of Trisama, an Ayurvedic Formulation on Intestinal Transit Time in Swiss Albino Mice. Ayu. 2018, 39(1), 46. DOI: 10.4103/ayu.AYU_33_18.
  • Shin, M. S.; Kim, S. B.; Lee, J.; Choi, H. S.; Park, J.; Park, J. Y.; Kang, K. S.; Hwang, G.; Koo, B.; Kang, K. Beneficial Effect of Herbal Formulation KM1608 on Inflammatory Bowl Diseases: A Preliminary Experimental Study. Molecules. 2018, 23(8), 2068. DOI: 10.3390/molecules23082068.
  • Tarasiuk, A.; Mosińska, P.; Fichna, J. Triphala: Current Applications and New Perspectives on the Treatment of Functional Gastrointestinal Disorders. Chin.Med. 2018, 13(1), 1–11. DOI: 10.1186/s13020-018-0197-6.
  • Gao, J.; Ajala, O. S.; Wang, C. Y.; Xu, H. Y.; Yao, J. H.; Zhang, H. P.; Ma, C. M.; Ma, C.-M. Comparison of Pharmacokinetic Profiles of Terminalia Phenolics after Intragastric Administration of the Aqueous Extracts of the Fruit of Terminalia Chebula and a Mongolian Compound medicine-Gurigumu-7. J. Ethnopharmacol. 2016, 185, 300–309. DOI: 10.1016/j.jep.2016.03.016.
  • Wang, H.; Shi, S.; Wang, S. Can Highly Cited Herbs in Ancient Traditional Chinese Medicine Formulas and Modern Publications Predict Therapeutic Targets for Diabetes Mellitus? J. Ethnopharmacol. 2018, 213, 101–110. DOI: 10.1016/j.jep.2017.10.032.
  • Shokoohi, R.; Kianbakht, S.; Faramarzi, M.; Rahmanian, M.; Nabati, F.; Mehrzadi, S.; Huseini, H. F. Effects of an Herbal Combination on Glycemic Control and Lipid Profile in Diabetic Women: A Randomized, double-blind, placebo-controlled Clinical Trial. Evid.-based Complement. Altern. Med. 2017, 22(4), 798–804. DOI: 10.1177/2156587217737683.
  • Bansode, T. S.; Salalkar, B. K.; Dighe, P.; Nirmal, S.; Dighe, S. Comparative Evaluation of Antidiabetic Potential of Partially Purified Bioactive Fractions from Four Medicinal Plants in alloxan-induced Diabetic Rats. Ayu. 2017, 38(3–4), 165. DOI: 10.4103/ayu.AYU_18_17.
  • Tupe, R. S.; Kemse, N. G.; Khaire, A. A.; Shaikh, S. A. Attenuation of glycation-induced Multiple Protein Modifications by Indian Antidiabetic Plant Extracts. Pharm. Bio. 2017, 55(1), 68–75. DOI: 10.1080/13880209.2016.1228683.
  • Borgohain, R. A. K. T. I.; Lahon, M.; Das, K. I. N. G. S. H. U. K.; Gohain, K. A. L. P. A. N. A, S. W. A. R. N. A. M. O. N. I. Evaluation of Mechanism of anti-diabetic Activity of Terminalia Chebula on Alloxan and Adrenaline Induced Diabetic Albino Rats. Drugs. 2002, 19, 05.
  • Senthilkumar, G. P.; Subramanian, S. P. Biochemical Studies on the Effect of Terminalia Chebula on the Levels of Glycoproteins in streptozotocin-induced Experimental Diabetes in Rats. J. Appl. Biomed. 2008, 6(2), 2. DOI: 10.32725/jab.2008.014.
  • Shyni, G. L.; Kavitha, S.; Indu, S.; Arya, A. D.; Anusree, S. S.; Vineetha, V. P.; Raghu, K. G.; Sundaresan, A.; Raghu, K. G. Chebulagic Acid from Terminalia Chebula Enhances Insulin Mediated Glucose Uptake in 3T3-L1 Adipocytes via PPARγ Signaling Pathway. BioFactors. 2014, 40(6), 646–657. DOI: 10.1002/biof.1193.
  • Pingali, U.; Sukumaran, D.; Nutalapati, C. Effect of an Aqueous Extract of Terminalia Chebula on Endothelial Dysfunction, Systemic Inflammation, and Lipid Profile in Type 2 Diabetes Mellitus: A Randomized Double‐blind, Placebo‐controlled Clinical Study. Phytotherapy Res. 2020, 34(12), 3226–3235. DOI: 10.1002/ptr.6771.
  • Shendge, A. K.; Sarkar, R.; Mandal, N. Potent Anti‐inflammatory Terminalia Chebula Fruit Showed in Vitro Anticancer Activity on Lung and Breast Carcinoma Cells through the Regulation of Bax/Bcl‐2 and Caspase‐cascade Pathways. J. Food Biochem. 2020, 44(12), e13521. DOI: 10.1111/jfbc.13521.
  • Ahuja, R.; Agrawal, N.; Mukerjee, A. Evaluation of Anticancer Potential of Terminalia Chebula Fruits against Ehrlich Ascites Carcinoma Induced Cancer in Mice. J. Sci. Innov. Res. 2013, 2(3), 549–554.
  • Shankara, B. R.; Ramachandra, Y. L.; Rajan, S. S.; Ganapathy, P. S.; Yarla, N. S.; Richard, S. A.; Dhananjaya, B. L. Evaluating the Anticancer Potential of Ethanolic Gall Extract of Terminalia Chebula (Gaertn.) Retz. (Combretaceae). Pharmacogn. Res. 2016, 8(3), 209. DOI: 10.4103/0974-8490.182919.
  • Wani, K.; Shah, N.; Prabhune, A.; Jadhav, A.; Ranjekar, P.; Kaul-Ghanekar, R. Evaluating the Anticancer Activity and Nanoparticulate Nature of Homeopathic Preparations of Terminalia Chebula. Homeopathy. 2016, 105(4), 318–326. DOI: 10.1016/j.homp.2016.02.004.
  • Mathiyazhagan, J.; Siva, R.; Jayaraj, R.; Madhyastha, H.; Kodiveri Muthukaliannan, G. Preventive Effect of Combined Zingiber Officinale and Terminalia Chebula against DMBA-Induced Breast Cancer Rats via mTOR Inhibition. Nutr. Cancer. 2022, 74(2), 687–696. DOI: 10.1080/01635581.2021.1903948.
  • Bag, A.; Bhattacharyya, S. K.; Chattopadhyay, R. R. The Development of Terminalia Chebula Retz. (Combretaceae) in Clinical Research. Asian Pac. J. Trop. Biomed. 2013, 3(3), 244–252. DOI: 10.1016/S2221-1691(13)60059-3.
  • Shen, Y. C.; Juan, C. W.; Lin, C. S.; Chen, C. C.; Chang, C. L. Neuroprotective Effect of Terminalia Chebula Extracts and Ellagic Acid in pc12 Cells. Afr. J. Tradit. Complement. Altern. Med. 2017, 14(4), 22–30. DOI: 10.21010/ajtcam.v14i4.3.
  • Alzheimer’s Association. 2017 Alzheimer’s Disease Facts and Figures. Alzheimer’s Dementia. 2017, 13(4), 325–373. doi:10.1016/j.jalz.2017.02.001.
  • Adhami, H. R.; Farsam, H.; Krenn, L. Screening of Medicinal Plants from Iranian Traditional Medicine for Acetylcholinesterase Inhibition. Phytother. Res. 2011, 25(8), 1148–1152. DOI: 10.1002/ptr.3409.
  • Anand, P.; Singh, B.; Singh, N. A Review on Coumarins as Acetylcholinesterase Inhibitors for Alzheimer’s Disease. Bioorg. Med. Chem. 2012, 20(3), 1175–1180. DOI: 10.1016/j.bmc.2011.12.042.
  • Dhar, A.; Maurya, S. K.; Mishra, A.; Singh, G. K.; Singh, M. K.; Seth, A. Preliminary Screening of a Classical Ayurvedic Formulation for Anticonvulsant Activity. Anc. Sci. Life. 2016, 36(1), 28. DOI: 10.4103/0257-7941.195410.
  • Debnath, J.; Sharma, U. R.; Kumar, B.; Chauhan, N. S. Anticonvulsant Activity of Ethanolic Extract of Fruits of Terminalia Chebula on Experimental Animals. Ijddr. 2010, 2(4).
  • Kumar, R.; Arora, R.; Agarwal, A.; Gupta, Y. K. Protective Effect of Terminalia Chebula against Seizures, seizure-induced Cognitive Impairment and Oxidative Stress in Experimental Models of Seizures in Rats. J. Ethnopharmacol. 2018, 215, 124–131. DOI: 10.1016/j.jep.2017.12.008.
  • Liu, Q. S.; Zhang, W. W.; Yin, X. Y.; Li, X. Neuro-protective Effects and Mechanism of Terminalia Chebula Extract HZ4 on Cerebral Infarction Models. Zhongguo Zhong yao za zhi= Zhongguo Zhongyao Zazhi= Chin. Med. J. 2016, 41(10), 1910–1915.
  • Kim, H. J.; Kim, J.; Kang, K. S.; Lee, K. T.; Yang, H. O. Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells. Biomol. Ther. 2014, 22(4), 275. DOI: 10.4062/biomolther.2014.068.
  • Jami, M. S. I.; Sultana, Z.; Ali, M. E.; Begum, M. M.; Haque, M. M. Evaluation of Analgesic and anti-inflammatory Activities on Ethanolic Extract of Terminalia Chebula; Fruits in Experimental Animal Models. Am. J. Plant Sci. 2014, 5, 63–69. DOI: 10.4236/ajps.2014.51010.
  • Pokuri, V. K.; Kumar, C. U.; Pingali, U. A Randomized, double-blind, placebo-controlled, cross-over Study to Evaluate Analgesic Activity of Terminalia Chebula in Healthy Human Volunteers Using A Mechanical Pain Model. J. Anaesthesiol. Clin. Pharmacol. 2016, 32(3), 329. DOI: 10.4103/0970-9185.173365.
  • Sireeratawong, S.; Jaijoy, K.; Khonsung, P.; Soonthornchareonnon, N. Analgesic and anti-inflammatory Activities of the Water Extract from Terminalia Chebula Rezt. Afr. J. Trad. Complem. Altern. Med. 2014, 11(6), 77–82. DOI: 10.4314/ajtcam.v11i6.8.
  • Kumar, C. U.; Pokuri, V. K.; Pingali, U. Evaluation of the Analgesic Activity of Standardized Aqueous Extract of Terminalia Chebula in Healthy Human Participants Using Hot Air Pain Model. Jcdr. 2015, 9(5), FC01.
  • Pansare, T. A.; Sole, A. P. The Vayasthapan Karma (Age Sustaining Action) Of Haritaki (Terminalia Chebula Retz.)-A Review. Int. J. Ayurvedic & Herb. Med. 2017, 7(2), 2484–2500.
  • Bag, A.; Kumar Bhattacharyya, S.; Kumar Pal, N.; Ranjan Chattopadhyay, R. Anti-inflammatory, anti-lipid Peroxidative, Antioxidant and Membrane Stabilizing Activities of Hydroalcoholic Extract of Terminalia Chebula Fruits. Pharm. Biol. 2013, 51(12), 1515–1520. DOI: 10.3109/13880209.2013.799709.
  • Mallik, J.; Das, P.; Karon, B.; Das, S. A Review on Phytochemistry and Pharmacological Activity of Terminalia Belerica. Ijdfr. 2012, 3(6), 1–7.
  • Mensah, M. L.; Komlaga, G.; Forkuo, A. D.; Firempong, C.; Anning, A. K.; Dickson, R. A. Toxicity and Safety Implications of Herbal Medicines Used in Africa. Herb. Med. 2019, 63, 1992–0849.
  • Kanna, S.; Hiremath, S. K.; Unger, B. S. Nephroprotective Activity of Bilvādi Agada in Gentamicin Induced Nephrotoxicity in Male Wistar Rats. Anc. Sci. Life. 2015, 34(3), 126. DOI: 10.4103/0257-7941.157146.
  • Gopi, K. S.; Reddy, A. G.; Jyothi, K.; Kumar, B. A. Acetaminophen-induced Hepato-and Nephrotoxicity and Amelioration by Silymarin and Terminalia Chebula in Rats. Toxicol. Int. 2010, 17(2), 64. DOI: 10.4103/0971-6580.72672.
  • Kalra, P.; Karwasra, R.; Gupta, Y. K.; Ray, S. B.; Singh, S. Terminalia Chebula Supplementation Attenuates cisplatin-induced Nephrotoxicity in Wistar Rats through Modulation of Apoptotic Pathway. Nat. Prod. Res. 2019, 33(11), 1641–1645. DOI: 10.1080/14786419.2018.1425843.
  • Lee, H. S.; Won, N. H.; Kim, K. H.; Lee, H.; Jun, W.; Lee, K. W. Antioxidant Effects of Aqueous Extract of Terminalia Chebula in Vivo and in Vitro. Biol. Pharm. Bull. 2005, 28(9), 1639–1644. DOI: 10.1248/bpb.28.1639.
  • Suchalatha, S.; Devi, C. S. S. Protective effect of Terminalia chebula against lysosomal enzyme alterations in isoproterenol-induced cardiac damage in rats. Exp. Clin. Cardiol. 2005, 10(2), 91–95.
  • Huang, X. J.; Wang, J.; Muhammad, A.; Tong, H. Y.; Wang, D. G.; Li, J.; Yang, G. Z.; Yang, G.-Z. Systems pharmacology-based Dissection of Mechanisms of Tibetan Medicinal Compound Ruteng as an Effective Treatment for collagen-induced Arthritis Rats. J. Ethnopharmacology. 2021, 272, 113953. DOI: 10.1016/j.jep.2021.113953.
  • Feng, X. H.; Xu, H. Y.; Wang, J. Y.; Duan, S.; Wang, Y. C.; Ma, C. M. In Vivo Hepatoprotective Activity and the Underlying Mechanism of Chebulinic Acid from Terminalia Chebula Fruit. Phytomedicine. 2021, 83, 153479. DOI: 10.1016/j.phymed.2021.153479.