365
Views
54
CrossRef citations to date
0
Altmetric
Original

A double-blind, randomized, placebo-controlled trial of the effect of testosterone cream on the sexual motivation of menopausal hysterectomized women with hypoactive sexual desire disorder

, &
Pages 335-343 | Received 23 Oct 2006, Accepted 02 Feb 2007, Published online: 03 Jul 2009

References

  • Chakravarti S, Collins W P, Newton J R, Oram D H, Studd J WW. Endocrine changes and symptomatology after oophorectomy in premenopausal women. Br J Obstet Gynaecol 1977; 84: 769–775
  • Burger H G, Hailes J, Menelaus M, Nelson J, Hudson B, Balazs N. The management of persistent menopausal symptoms with oestrogen and testosterone implants: clinical, lipid and hormonal results. Maturitas 1984; 6: 351–358
  • Sherwin B B, Gelfand M M, Brender W. Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom Med 1985; 47: 339–351
  • Sherwin B B, Gelfand M M. The role of androgen in the maintenance of sexual functioning in oophorectomized women. Psychosom Med 1987; 49: 397–409
  • Sherwin B B. Affective changes with estrogen and androgen replacement therapy in surgically menopausal women. J Affect Disorders 1988; 14: 177–187
  • Sherwin B B. Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women. Psychoneuroendocrinology 1988; 13: 345–357
  • Shifren J L, Braunstein G D, Simon J A, et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000; 343: 682–688
  • Kaplan H S, Owett T. The female androgen deficiency syndrome. J Sex Marital Therapy 1993; 19: 3–24
  • Davis S R, McCloud P, Straus B J, Burger H. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 1995; 21: 227–236
  • Raisz L G, Wiita B, Artis A, et al. Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women. J Clin Endocrinol. Metab 1996; 81: 37–43
  • Floter A, Nathorst-Boos J, Carlstrom K, von Schoultz B. Addition of testosterone to estrogen replacement therapy in oophorectomized women: effects on sexuality and well-being. Climacteric 2002; 5: 357–365
  • Watts N B, Notelovitz M, Timmons M C, Addison B. Comparison of oral estrogens and estrogens plus androgen on bone mineral density, menopausal symptoms, and lipid-lipoprotein profiles in surgical menopause. Obstet Gynecol 1995; 85: 529–536
  • Davidson J M. Sexual behaviour and its relationship to ovarian hormones in the menopause. Maturitas 1985; 7: 193–201
  • Braunstein G D, Sundwall D A, Katz M, et al. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women. Arch Intern Med 2005; 165: 1582–1589
  • Buster J E, Kingsberg S A, Aguirre O, et al. Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial. Obstet Gynecol 2005; 105: 944–952
  • Simon J, Braunstein G, Nachtigall L, et al. Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder. J Clin Endocrinol Metab 2005; 90: 5226–5233
  • Taylor J F, Rosen R C, Leiblum S R. Self-report assessment of female sexual function: psychometric evaluation of the Brief Index of Sexual Functioning for Women. Arch Sex Behav 1994; 23: 627–643
  • McNair D M, Lorr M, Droppleman L F. The Edits Manual for the Profile of Mood States. Edits/Educational and industrial testing service, San Diego, California 1992
  • Lovibond S H, Lovibond P F. Manual for the Depression, Anxiety Stress Scales2nd edn. Psychological Foundation, Sydney 1995
  • Ferriman D, Gallwey J. Clinical assessment of body hair growth in women. J Clin Endocrin 1961; 21: 1440–1447
  • Rosenberg M J, King T D, Timmons M C. Estrogen-androgen for hormone replacement. A review. J Reprod Med 1997; 42: 394–404
  • Dow M G, Hart D M, Forrest C A. Hormonal treatments of sexual unresponsiveness in postmenopausal women: a comparative study. Br J Obstet Gynaecol 1983; 90: 361–366
  • Eden JA. A novel testosterone cream. Presented at the International Menopause Society Meeting, Berlin 2002.
  • Urman B, Pride S M, Yuen B H. Elevated serum testosterone, hirsutism and virilism associated with combined androgen-estrogen hormone replacement therapy. Obstet Gynecol 1991; 77: 595–598
  • Tamimi R M, Hankinson S E, Chen W Y, Rosner B, Colditz G A. Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women. Arch Intern Med 2006; 166: 1483–1489
  • Dimitrakakis C, Jones R A, Liu A, Bondy C A. Breast cancer incidence in postmenopausal women using testosterone therapy in addition to usual hormone therapy. Menopause 2004; 11: 531–535

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.