Determinants of attained estradiol levels in response to oral estradiol plus progesterone therapy

References

• Barbieri RL. Hormone treatment of endometriosis: the estrogen threshold hypothesis. Am J Obstet Gynecol 1992;166:740–5
   PubMed Web of Science ®Google Scholar
• Yasui T, Uemura H, Tezuka M, et al. Biological effects of hormone replacement therapy in relation to serum estradiol levels. Horm Res Paediatr 2001;56:38–44
   Google Scholar
• Sriprasert I, Hodis HN, Karim R, et al. Differential effect of plasma estradiol on subclinical atherosclerosis progression in early versus late postmenopause. J Clin Endocrinol Metab 2018;104:293–300
   Web of Science ®Google Scholar
• Sriprasert I, Hodis HN, Bernick B, et al. Effect of estradiol dose and serum estradiol level on metabolic measures in early and late postmenopausal women in the REPLENISH trial. Menopause 2019;26:1456
   Web of Science ®Google Scholar
• Kuhl H. Pharmacology of estrogens and progestogens: influence of different routes of administration. Climacteric 2005;8(Suppl 1):3–63
   PubMed Web of Science ®Google Scholar
• O'Connell MB. Pharmacokinetic and pharmacologic variation between different estrogen products. J Clin Pharmacol 1995;35:18S–24S
   PubMed Web of Science ®Google Scholar
• Stanczyk FZ, Archer DF, Bhavnani BR. Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment. Contraception 2013;87:706–27
   PubMed Web of Science ®Google Scholar
• Pickar JH, Bon C, Amadio JM, et al. Pharmacokinetics of the first combination 17β-estradiol/progesterone capsule in clinical development for menopausal hormone therapy. Menopause 2015;22:1308–16
   PubMed Web of Science ®Google Scholar
• Mirkin S, Amadio JM, Bernick BA, et al. 17β-Estradiol and natural progesterone for menopausal hormone therapy: REPLENISH phase 3 study design of a combination capsule and evidence review. Maturitas 2015;81:28–35
   PubMed Web of Science ®Google Scholar
• Constantine G, Revicki DA, Kagan R, et al. TX-001HR is Associated with a Clinically Meaningful Effect on Vasomotor Symptoms. 28th Annual Meeting of The North American Menopause Society; 2017 Oct 11–14; Philadelphia, PA. Menopause 2017;24:1428
   Google Scholar
• Lobo RA, Archer DF, Constantine G, et al. 17b-Estradiol/Progesterone in a Single Oral Softgel Capsule (TX-001HR) Significantly Reduced Moderate-to-Severe Vasomotor Symptoms without Endometrial Hyperplasia (28th Annual Meeting of The North American Menopause Society October 11-14, 2017, Philadelphia, PA.). Menopause 2017;24:1430
   Google Scholar
• Goldstein SR, Constantine G, Archer DF, et al. Effects of TX-001HR on Uterine Bleeding Rates in Menopausal Women with Vasomotor Symptoms. Menopause 2017;24:1431
   Web of Science ®Google Scholar
• Lobo RA, Archer DF, Kagan R, et al. A 17beta-estradiol-progesterone oral capsule for vasomotor symptoms in postmenopausal women: a randomized controlled trial. Obstet Gynecol 2018;132:161–70
   PubMed Web of Science ®Google Scholar
• Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31–41
   PubMed Web of Science ®Google Scholar
• Constantine GD, Liu J, Simon JA, et al. Baseline estradiol levels in postmenopausal women. Menopause 2019;26:1462
   Web of Science ®Google Scholar
• Ginsburg ES, Mello NK, Mendelson JH, et al. Effects of alcohol ingestion on estrogens in postmenopausal women. JAMA 1996;276:1747–51
   PubMed Web of Science ®Google Scholar
• Endogenous Hormones and Breast Cancer Collaborative Group, Key TJ, et al. Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies. Br J Cancer 2011;105:709–22
   PubMed Web of Science ®Google Scholar
• Playdon MC, Coburn SB, Moore SC, et al. Alcohol and oestrogen metabolites in postmenopausal women in the Women's Health Initiative Observational Study. Br J Cancer 2018;118:448–57
   PubMed Web of Science ®Google Scholar
• Gill J. The effects of moderate alcohol consumption on female hormone levels and reproductive function. Alcohol Alcohol 2000;35:417–23
   PubMed Web of Science ®Google Scholar
• Rinaldi S, Peeters PH, Bezemer ID, et al. Relationship of alcohol intake and sex steroid concentrations in blood in pre- and post-menopausal women: the European prospective investigation into cancer and nutrition. Cancer Causes Control 2006;17:1033–43
   PubMed Web of Science ®Google Scholar
• Onland-Moret NC, Peeters PH, van der Schouw YT, et al. Alcohol and endogenous sex steroid levels in postmenopausal women: a cross-sectional study. J Clin Endocrinol Metab 2005;90:1414–19
   PubMed Web of Science ®Google Scholar
• Shafrir AL, Zhang X, Poole EM, et al. The association of reproductive and lifestyle factors with a score of multiple endogenous hormones. Horm Cancer 2014;5:324–35
   PubMed Web of Science ®Google Scholar
• Sarkola T, Makisalo H, Fukunaga T, et al. Acute effect of alcohol on estradiol, estrone, progesterone, prolactin, cortisol, and luteinizing hormone in premenopausal women. Alcohol Clin Exp Res 1999;23:976–82
   PubMed Web of Science ®Google Scholar
• Geisler J, Omsjo IH, Helle SI, et al. Plasma oestrogen fractions in postmenopausal women receiving hormone replacement therapy: influence of route of administration and cigarette smoking. J Endocrinol 1999;162:265–70
   PubMed Web of Science ®Google Scholar
• Mueck AO, Seeger H. Smoking, estradiol metabolism and hormone replacement therapy. Curr Med Chem Cardiovasc Hematol Agents 2005;3:45–54
   PubMedGoogle Scholar
• Ruan X, Mueck AO. Impact of smoking on estrogenic efficacy. Climacteric 2015;18:38–46
   PubMed Web of Science ®Google Scholar
• Lobo RA, Cassidenti DL. Pharmacokinetics of oral 17 beta-estradiol. J Reprod Med 1992;37:77–84
   PubMed Web of Science ®Google Scholar
• Michnovicz JJ, Hershcopf RJ, Naganuma H, et al. Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking. N Engl J Med 1986;315:1305–9
   PubMed Web of Science ®Google Scholar
• Yasui T, Uemura H, Umino Y, et al. Serum estrogen level after hormone replacement therapy and body mass index in postmenopausal and bilaterally ovariectomized women. Maturitas 2005;50:19–29
   PubMed Web of Science ®Google Scholar
• McTiernan A, Wu L, Chen C, et al. Relation of BMI and physical activity to sex hormones in postmenopausal women. Obesity 2006;14:1662–77
   PubMed Web of Science ®Google Scholar
• Baglietto L, English DR, Hopper JL, et al. Circulating steroid hormone concentrations in postmenopausal women in relation to body size and composition. Breast Cancer Res Treat 2009;115:171–9
   PubMed Web of Science ®Google Scholar
• Karim R, Mack WJ, Hodis HN, et al. Influence of age and obesity on serum estradiol, estrone, and sex hormone binding globulin concentrations following oral estrogen administration in postmenopausal women. J Clin Endocrinol Metab 2009;94:4136–43
   PubMed Web of Science ®Google Scholar
• Hetemaki N, Savolainen-Peltonen H, Tikkanen MJ, et al. Estrogen metabolism in abdominal subcutaneous and visceral adipose tissue in postmenopausal women. J Clin Endocrinol Metab 2017;102:4588–95
   PubMed Web of Science ®Google Scholar
• Gruber CJ, Tschugguel W, Schneeberger C, et al. Production and actions of estrogens. N Engl J Med 2002;346:340–52
   PubMed Web of Science ®Google Scholar
• Edlefsen KL, Jackson RD, Prentice RL, et al. The effects of postmenopausal hormone therapy on serum estrogen, progesterone, and sex hormone-binding globulin levels in healthy postmenopausal women. Menopause 2010;17:622–9
   PubMed Web of Science ®Google Scholar