The involvement of MALAT1-ALKBH5 signaling axis into proliferation and metastasis of human papillomavirus-positive cervical cancer

References

• Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–14. doi:10.3322/caac.21262.
   PubMed Web of Science ®Google Scholar
• Wright JD, Huang Y, Ananth CV, Tergas AI, Duffy C, Deutsch I, Burke WM, Hou JY, Neugut AI, Hershman DL, et al. Influence of treatment center and hospital volume on survival for locally advanced cervical cancer. Gynecol Oncol. 2015;139(3):506–512. doi:10.1016/j.ygyno.2015.07.015.
   PubMed Web of Science ®Google Scholar
• Chen S, Gao C, Wu Y, Huang Z. Identification of prognostic miRNA signature and lymph node metastasis-related key genes in cervical cancer. Front Pharmacol. 2020;11:544. doi:10.3389/fphar.2020.00544.
   PubMed Web of Science ®Google Scholar
• Crow JM. HPV: The global burden. Nature. 2012;488(7413):S2–S3. doi:10.1038/488S2a.
   PubMed Web of Science ®Google Scholar
• Lowy DR, Solomon D, Hildesheim A, Schiller JT, Schiffman M. Human papillomavirus infection and the primary and secondary prevention of cervical cancer. Cancer. 2008;113(S7):1980–1993. doi:10.1002/cncr.23704.
   PubMedGoogle Scholar
• Smith JS, Lindsay L, Hoots B, Keys J, Franceschi S, Winer R, Clifford GM. Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update. Int J Cancer. 2007;121(3):621–632. doi:10.1002/ijc.22527.
   PubMed Web of Science ®Google Scholar
• Adams BD, Parsons C, Walker L, Zhang WC, Slack FJ. Targeting noncoding RNAs in disease. J Clin Invest. 2017;127(3):761–771. doi:10.1172/JCI84424.
   PubMed Web of Science ®Google Scholar
• Hu T, Zhang Q, Gao L. LncRNA CAR10 upregulates PDPK1 to promote cervical cancer development by sponging miR-125b-5p. BioMed Res Int. 2020;2020:4351671. doi:10.1155/2020/4351671.
   PubMed Web of Science ®Google Scholar
• Jin X-J, Chen X-J, Zhang Z-F, Hu W-S, Ou R-Y, Li S, Xue J-S, Chen L-L, Hu Y, Zhu H, et al. Long noncoding RNA SNHG12 promotes the progression of cervical cancer via modulating miR-125b/STAT3 axis. J Cell Physiol. 2019;234(5):6624–6632. doi:10.1002/jcp.27403.
   PubMed Web of Science ®Google Scholar
• Jin X, Chen X, Hu Y, Ying F, Zou R, Lin F, Shi Z, Zhu X, Yan X, Li S, et al. LncRNA-TCONS_00026907 is involved in the progression and prognosis of cervical cancer through inhibiting miR-143-5p. Cancer Med. 2017;6(6):1409–1423. doi:10.1002/cam4.1084.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang T, Huang H-Q, Li W, Cheng X-L, Yang J. Human MALAT-1 long non-coding RNA is overexpressed in cervical cancer metastasis and promotes cell proliferation, invasion and migration. J BUON. 2015;20(6):1497–1503.
   PubMed Web of Science ®Google Scholar
• Li Y, Ding Y, Ding N, Zhang H, Lu M, Cui X, Yu X. MicroRNA-625-5p sponges lncRNA MALAT1 to inhibit cervical carcinoma cell growth by suppressing NF-κB signaling. Cell Biochem Biophys. 2020;78(2):217–225. doi:10.1007/s12013-020-00904-7.
   PubMed Web of Science ®Google Scholar
• Xia C, Liang S, He Z, Zhu X, Chen R, Chen J. Metformin, a first-line drug for type 2 diabetes mellitus, disrupts the MALAT1/miR-142-3p sponge to decrease invasion and migration in cervical cancer cells. Eur J Pharmacol. 2018;830:59–67. doi:10.1016/j.ejphar.2018.04.027.
   PubMed Web of Science ®Google Scholar
• Xu Z, Jia K, Wang H, Gao F, Zhao S, Li F, Hao J. METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial–mesenchymal transition of renal tubular cells in diabetic kidney disease. Cell Death Disease. 2021;12(1):32. doi:10.1038/s41419-020-03312-0.
   PubMed Web of Science ®Google Scholar
• Zhang P, He Q, Lei Y, Li Y, Wen X, Hong M, Zhang J, Ren X, Wang Y, Yang X, et al. mA-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression. Cell Death Disease. 2018;9(12):1169. doi:10.1038/s41419-018-1224-3.
   PubMed Web of Science ®Google Scholar
• Luo J, Xu T, Sun K. N6-methyladenosine RNA modification in inflammation: roles, mechanisms, and applications. Front Cell Dev Biol. 2021;9:670711. doi:10.3389/fcell.2021.670711.
   PubMed Web of Science ®Google Scholar
• Zhang S, Zhao BS, Zhou A, Lin K, Zheng S, Lu Z, Chen Y, Sulman E.P, Xie K, Bögler O et al. 2017. mA demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program. Cancer Cell. 31(4):312017.
   Web of Science ®Google Scholar
• Chen Y, Zhao Y, Chen J, Peng C, Zhang Y, Tong R, Cheng Q, Yang B, Feng X, Lu Y, et al. ALKBH5 suppresses malignancy of hepatocellular carcinoma via m(6)A-guided epigenetic inhibition of LYPD1. Mol Cancer. 2020;19(1):123. doi:10.1186/s12943-020-01239-w.
   PubMed Web of Science ®Google Scholar
• Zhang S, Zhao BS, Zhou A, Lin K, Zheng S, Lu Z, Chen Y, Sulman EP, Xie K, Bögler O, et al. m(6)A demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program. Cancer Cell. 2017;31(4):591–606.e6. doi:10.1016/j.ccell.2017.02.013.
   PubMed Web of Science ®Google Scholar
• Qiu X, Yang S, Wang S, Wu J, Zheng B, Wang K, Shen S, Jeong S, Li Z, Zhu Y, et al. M(6)A demethylase ALKBH5 regulates PD-L1 expression and tumor Immunoenvironment in Intrahepatic cholangiocarcinoma. Cancer Res. 2021;81(18):4778–4793. doi:10.1158/0008-5472.CAN-21-0468.
   PubMed Web of Science ®Google Scholar
• Yi YC, Chen XY, Zhang J, Zhu JS. Novel insights into the interplay between m(6)A modification and noncoding RNAs in cancer. Mol Cancer. 2020;19(1):121. doi:10.1186/s12943-020-01233-2.
   PubMed Web of Science ®Google Scholar
• Usai A, Di Franco G, Colucci P, Pollina LE, Vasile E, Funel N, Palmeri M, Dente L, Falcone A, Morelli L, et al. A model of a zebrafish avatar for Co-clinical trials. Cancers. 2020;12(3):677. doi:10.3390/cancers12030677.
   PubMed Web of Science ®Google Scholar
• Chang YZ, Chai RC, Pang B, Chang X, An SY, Zhang K-N, Jiang T, Wang Y-Z. METTL3 enhances the stability of MALAT1 with the assistance of HuR via m6A modification and activates NF-κB to promote the malignant progression of IDH-wildtype glioma. Cancer Lett. 2021;511:36–46. doi:10.1016/j.canlet.2021.04.020.
   PubMed Web of Science ®Google Scholar
• Tao L, Mu X, Chen H, Jin D, Zhang R, Zhao Y, Fan J, Cao M, Zhou Z. FTO modifies the m6A level of MALAT and promotes bladder cancer progression. Clin Transl Med. 2021;11(2):e310. doi:10.1002/ctm2.310.
   PubMed Web of Science ®Google Scholar
• Sun T, Wu Z, Wang X, Wang Y, Hu X, Qin W, Lu S, Xu D, Wu Y, Chen Q, et al. LNC942 promoting METTL14-mediated m6A methylation in breast cancer cell proliferation and progression. Oncogene. 2020;39(31):5358–5372. doi:10.1038/s41388-020-1338-9.
   PubMed Web of Science ®Google Scholar
• Li X, Liu B, Wang S, Li J, Ge X. MiR-141-3p promotes malignant progression in prostate cancer through AlkB homolog 5-mediated m6A modification of protein arginine methyltransferase 6. Chin J Physiol. 2023;66(1):43–51. doi:10.4103/cjop.CJOP-D-22-00071.
   PubMed Web of Science ®Google Scholar
• Zhao P, Liu S, Zhong Z, Hou J, Lin L, Weng R, Su L, Lei N, Hou T, Yang H. Prevalence and genotype distribution of human papillomavirus infection among women in northeastern Guangdong Province of China. BMC Infect Dis. 2018;18(1):204. doi:10.1186/s12879-018-3105-x.
   PubMedGoogle Scholar
• Duan R, Qiao Y, Clifford G, Zhao F. Cancer burden attributable to human papillomavirus infection by sex, cancer site, age, and geographical area in China. Cancer Med. 2020;9(1):374–384. doi:10.1002/cam4.2697.
   PubMed Web of Science ®Google Scholar
• Qureshi R, Arora H, Rizvi MA. EMT in cervical cancer: its role in tumour progression and response to therapy. Cancer Lett. 2015;356(2):321–331. doi:10.1016/j.canlet.2014.09.021.
   PubMed Web of Science ®Google Scholar
• Xing Y, Wen X, Ding X, Fan J, Chai P, Jia R, Ge S, Qian G, Zhang H, Fan X, et al. CANT1 lncRNA triggers efficient therapeutic efficacy by correcting aberrant lncing cascade in malignant uveal melanoma. Mol Ther. 2017;25(5):1209–1221. doi:10.1016/j.ymthe.2017.02.016.
   PubMed Web of Science ®Google Scholar
• Chen JH, Zhou LY, Xu S, Zheng YL, Wan YF, Hu CP. Overexpression of lncRNA HOXA11-AS promotes cell epithelial–mesenchymal transition by repressing miR-200b in non-small cell lung cancer. Cancer Cell Int. 2017;17(1):64. doi:10.1186/s12935-017-0433-7.
   PubMed Web of Science ®Google Scholar
• Chen M, Xia Z, Chen C, Hu W, Yuan Y. LncRNA MALAT1 promotes epithelial-to-mesenchymal transition of esophageal cancer through Ezh2-Notch1 signaling pathway. Anticancer Drugs. 2018;29(8):767–773. doi:10.1097/CAD.0000000000000645.
   PubMed Web of Science ®Google Scholar
• Lu H, He Y, Lin L, Qi Z, Ma L, Li L, Su Y. Long non-coding RNA MALAT1 modulates radiosensitivity of HR-HPV+ cervical cancer via sponging miR-145. Tumour Biol. 2016;37(2):1683–1691. doi:10.1007/s13277-015-3946-5.
   PubMedGoogle Scholar
• Tao L, Mu XY, Chen HG, Jin D, Zhang R, Zhao Y, Fan J, Cao M, Zhou Z. FTO modifies the m6A level of MALAT and promotes bladder cancer progression. Clin Transl Med. 2021;11(2):e310. doi:10.1002/ctm2.310.
   PubMed Web of Science ®Google Scholar
• Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang C-M, Li C, Vågbø C, Shi Y, Wang W-L, Song S-H, et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013;49(1):18–29. doi:10.1016/j.molcel.2012.10.015.
   PubMed Web of Science ®Google Scholar
• Deng X, Su R, Feng X, Wei M, Chen J. Role of N(6)-methyladenosine modification in cancer. Curr Opin Genet Dev. 2018;48:1–7. doi:10.1016/j.gde.2017.10.005.
   PubMed Web of Science ®Google Scholar
• Cheng M, Sheng L, Gao Q, Xiong Q, Zhang H, Wu M, Liang Y, Zhu F, Zhang Y, Zhang X, et al. The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network. Oncogene. 2019;38(19):3667–3680. doi:10.1038/s41388-019-0683-z.
   PubMed Web of Science ®Google Scholar
• Gong D, Zhao ZW, Zhang Q, Yu X-H, Wang G, Zou J, Zheng X-L, Zhang D-W, Yin W-D, Tang C-K, et al. The Long noncoding RNA metastasis-associated lung adenocarcinoma transcript-1 regulates CCDC80 expression by targeting miR-141-3p/miR-200a-3p in vascular smooth muscle cells. J Cardiovasc Pharmacol. 2020;75(4):336–343. doi:10.1097/FJC.0000000000000798.
   PubMed Web of Science ®Google Scholar
• Wu A, Sun W, Mou F. lncRNA‑MALAT1 promotes high glucose‑induced H9C2 cardiomyocyte pyroptosis by downregulating miR‑141‑3p expression. Mol Med Rep. 2021;23(4):259. doi:10.3892/mmr.2021.11898.
   PubMed Web of Science ®Google Scholar
• Jin D, Guo JW, Wu Y, Yang L, Wang X, Du J, Dai J, Chen W, Gong K, Miao S, et al. Correction: m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC. Mol Cancer. 2022;21(1):130. doi:10.1186/s12943-022-01593-x.
   PubMed Web of Science ®Google Scholar
• Liu XL, Wang ZY, Yang QW, Hu X, Fu Q, Zhang X, Li W. RNA demethylase ALKBH5 prevents lung cancer progression by regulating EMT and stemness via regulating p53. Front Oncol. 2022;12:858694. doi:10.3389/fonc.2022.858694.
   PubMed Web of Science ®Google Scholar
• Sun ZL, Su ZY, Zhou ZY, Wang S, Wang Z, Tong X, Li C, Wang Y, Chen X, Lei Z, et al. RNA demethylase ALKBH5 inhibits TGF-β-induced EMT by regulating TGF-β/SMAD signaling in non-small cell lung cancer. FASEB J. 2022;36(5):e22283. doi:10.1096/fj.202200005RR.
   PubMed Web of Science ®Google Scholar
• Hao LL, Yin JY, Yang H, Li C, Zhu L, Liu L, Zhong J. ALKBH5-mediated m(6)A demethylation of FOXM1 mRNA promotes progression of uveal melanoma. Aging-Us. 2021;13(3):4045–4062. doi:10.18632/aging.202371.
   Web of Science ®Google Scholar
• Chao YH, Shang J, Ji WD. ALKBH5-m(6)A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia. Biochem Bioph Res Co. 2020;521(2):499–506. doi:10.1016/j.bbrc.2019.10.145.
   PubMed Web of Science ®Google Scholar