Cancer Biology & Therapy, Volume 24, Issue 1 (2023)

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Cancer Biology & Therapy, Volume 24, Issue 1 (2023)

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Review

Review
The impact of radiation dose on the efficacy of definitive chemoradiotherapy in patients with locally advanced esophageal carcinoma: a systematic review and meta-analysis
Danjing Luo, Qiulu Zhong & Xiaodong Zhu
Article: 2156246
Published online: 15 Dec 2022
AbstractforThe impact of radiation dose on the efficacy of definitive chemoradiotherapy in patients with locally advanced esophageal carcinoma: a systematic review and meta-analysis | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
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Research Paper

Article
Combination of metformin/efavirenz/fluoxetine exhibits profound anticancer activity via a cancer cell-specific ROS amplification
Beom-Goo Kang, Madhuri Shende, Gozde Inci, Soo-Hyun Park, Jun-Sub Jung, Set Byeol Kim, Jeong Hoon Kim, Young Won Mo, Ji-Hyeon Seo, Jing-Hui Feng, Sung-Chan Kim, Soon Sung Lim, Hong-Won Suh & Jae-Yong Lee
Article: 2161803
Published online: 01 Jan 2023
AbstractforCombination of metformin/efavirenz/fluoxetine exhibits profound anticancer activity via a cancer cell-specific ROS amplification | Full Text | References | PDF (3.9 MB) | EPUB
  • 5128 Views
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Open Access
Article
Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma
Minxiao Chen, Chenchen Qian, Bo Jin, Chenghong Hu, Lingxi Zhang, Minshan Wang, Bin Zhou, Wei Zuo, Lijiang Huang & Yi Wang
Article: 2162807
Published online: 16 Jan 2023
AbstractforCurcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 3807 Views
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Open Access
Article
Knockdown of LINC00511 enhances radiosensitivity of lung adenocarcinoma via regulating miR-497-5p/SMAD3
Chongxin Li, Yanyan Fu, Yongmei He, Nan Huang, Jun Yue, Yi Miao, Jialing Lv, Youchuan Xiao, Ruoyu Deng, Chao Zhang & Meifang Huang
Article: 2165896
Published online: 02 Mar 2023
AbstractforKnockdown of LINC00511 enhances radiosensitivity of lung adenocarcinoma via regulating miR-497-5p/SMAD3 | Full Text | References | PDF (6.8 MB) | EPUB | Supplemental
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Open Access
Article
The impact of drug-eluting bead (vs. conventional) transarterial chemoembolization on hepatic fibrosis in treating intermediate or advanced hepatocellular carcinoma
Hao Li, Chao Liang, Donglin Kuang, Guohao Huang, Mengfan Zhang, Pengfei Chen, Qingzhu Zheng, Wenze Xu, Jianzhuang Ren, Xinwei Han & Xuhua Duan
Article: 2166335
Published online: 07 Feb 2023
AbstractforThe impact of drug-eluting bead (vs. conventional) transarterial chemoembolization on hepatic fibrosis in treating intermediate or advanced hepatocellular carcinoma | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 2988 Views
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Open Access
Article
Targeting endoplasmic reticulum associated degradation pathway combined with radiotherapy enhances the immunogenicity of esophageal cancer cells
Hui Luo, Yanan Sun, Liuxiang Wang, Hui Liu, Ran Zhao, Mengqiu Song & Hong Ge
Article: 2166763
Published online: 12 Mar 2023
AbstractforTargeting endoplasmic reticulum associated degradation pathway combined with radiotherapy enhances the immunogenicity of esophageal cancer cells | Full Text | References | PDF (8.2 MB) | EPUB | Supplemental
  • 2478 Views
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Open Access
Article
Integrating DOI in T classification improves the predictive performance of laryngeal cancer staging
Xueying Wang, Kui Cao, Erliang Guo, Xionghui Mao, Changming an, Lunhua Guo, Cong Zhang, Xianguang Yang, Ji Sun, Weiwei Yang, Xiaomei Li & Susheng Miao
Article: 2169040
Published online: 02 Feb 2023
AbstractforIntegrating DOI in T classification improves the predictive performance of laryngeal cancer staging | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 2104 Views
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Open Access
Article
NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma
Jaclyn M. Kubala, Kristian B. Laursen, Ryan Schreiner, Ryan M. Williams, Johannes C. van der Mijn, Michael J. Crowley, Nigel P. Mongan, David M. Nanus, Daniel A. Heller & Lorraine J. Gudas
Article: 2170669
Published online: 01 Feb 2023
AbstractforNDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
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Open Access
Article
Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering †
Nagamani Vunnam, Malaney C. Young, Elly E. Liao, Chih Hung Lo, Evan Huber, MaryJane Been, David D. Thomas & Jonathan N. Sachs
Article: 2176692
Published online: 12 Feb 2023
AbstractforNimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering † | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
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Article
Reprogramming of VEGF-mediated extracellular matrix changes through autocrine signaling
Eibhlin Goggins, Yelena Mironchik, Samata Kakkad, Desmond Jacob, Flonne Wildes, Zaver M. Bhujwalla & Balaji Krishnamachary
Article: 2184145
Published online: 09 Mar 2023
AbstractforReprogramming of VEGF-mediated extracellular matrix changes through autocrine signaling | Full Text | References | PDF (13.1 MB) | EPUB | Supplemental
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Article
Daucosterol combined with umbilical cord mesenchymal stem cell-derived exosomes can alleviate liver damage in liver failure mice by regulating the IL-6/STAT3 signaling pathway
Changqing Deng, Jia Hu, Ling He, Laian Ge, Na Wu, Mingjun Xie, Xiaojuan Yang, Chuncheng Wu & Qin Liu
Article: 2184150
Published online: 15 Mar 2023
AbstractforDaucosterol combined with umbilical cord mesenchymal stem cell-derived exosomes can alleviate liver damage in liver failure mice by regulating the IL-6/STAT3 signaling pathway | Full Text | References | PDF (2.8 MB) | EPUB
  • 3002 Views
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Open Access
Article
Colon adenocarcinoma and Birt–Hogg–Dubé syndrome in a young patient: case report and exploration of pathologic implications
Grant W. Jirka, Daniel S. Lefler, Jessica Russo & Babar Bashir
Article: 2184153
Published online: 01 Mar 2023
AbstractforColon adenocarcinoma and Birt–Hogg–Dubé syndrome in a young patient: case report and exploration of pathologic implications | Full Text | References | PDF (1,009.4 KB) | EPUB | Supplemental
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Open Access
Article
Ras interacting protein 1 facilitated proliferation and invasion of diffuse large B-cell lymphoma cells
Xiaojing Xing, Xuguang Wang, Meichen Liu, Qianxue Guo & Hongyue Wang
Article: 2193114
Published online: 26 Mar 2023
AbstractforRas interacting protein 1 facilitated proliferation and invasion of diffuse large B-cell lymphoma cells | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
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Journal Club

Article
Deep and lasting response and acquired resistance to BRAFV600E targeting in a low-grade ovarian cancer patient
Sandro Anchisi, Anita Wolfer, Bettina Bisig, Edoardo Missiglia, Amine Tiab, Ehab Mohamed Kamel, Olivier Michielin, George Coukos & Krisztian Homicsko
Article: 2193116
Published online: 26 Mar 2023
AbstractforDeep and lasting response and acquired resistance to BRAFV600E targeting in a low-grade ovarian cancer patient | Full Text | References | PDF (1.8 MB) | EPUB
  • 1876 Views
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Research Paper

Article
The v8-10 variant isoform of CD44 is selectively expressed in the normal human colonic stem cell niche and frequently is overexpressed in colon carcinomas during tumor development
Bruce M. Boman, Vignesh Viswanathan, Caroline O. B. Facey, Jeremy Z. Fields & James W. Stave
Article: 2195363
Published online: 02 Apr 2023
AbstractforThe v8-10 variant isoform of CD44 is selectively expressed in the normal human colonic stem cell niche and frequently is overexpressed in colon carcinomas during tumor development | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Review

Review
Isolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidence
Orimisan Samuel Adekolujo, Ahsan Wahab, Maxwell Oluwole Akanbi, Tolutope Oyasiji, Borys Hrinczenko & Olatunji Boladale Alese
Article: 2198479
Published online: 01 Aug 2023
AbstractforIsolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidence | Full Text | References | PDF (1,021 KB) | EPUB
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Research Paper

Article
LINC01060 knockdown inhibits osteosarcoma cell malignant behaviors in vitro and tumor growth and metastasis in vivo through the PI3K/Akt signaling
Qiang Zhang, Xinqiao Tang, Yi Zhou, Xiaoming Chen, Ke Peng, Ruizhong Jiang, Zhong Liu, Xiaoxia Song & Hong Xia
Article: 2198904
Published online: 21 May 2023
AbstractforLINC01060 knockdown inhibits osteosarcoma cell malignant behaviors in vitro and tumor growth and metastasis in vivo through the PI3K/Akt signaling | Full Text | References | PDF (6.7 MB) | EPUB | Supplemental
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Open Access
Article
Netrin-1 inducing antiapoptotic effect of acute myeloid leukemia cells in a concentration-dependent manner through the Unc-5 netrin receptor B-focal adhesion kinase axis
Kainan Zhang, Xizhou An, Yao Zhu, Lan Huang, Xinyuan Yao, Xing Zeng, Shaoyan Liang & Jie Yu
Article: 2200705
Published online: 10 Apr 2023
AbstractforNetrin-1 inducing antiapoptotic effect of acute myeloid leukemia cells in a concentration-dependent manner through the Unc-5 netrin receptor B-focal adhesion kinase axis | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
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Article
A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer
Sarah E. Paraghamian, Jianqing Qiu, Gabrielle M. Hawkins, Ziyi Zhao, Wenchuan Sun, Yali Fan, Xin Zhang, Hongyan Suo, Tianran Hao, Varun Vijay Prabhu, Joshua E. Allen, Chunxiao Zhou & Victoria Bae-Jump
Article: 2202104
Published online: 17 Apr 2023
AbstractforA novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer | Full Text | References | PDF (6.5 MB) | EPUB
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Article
Flotillin-1 enhances radioresistance through reducing radiation-induced DNA damage and promoting immune escape via STING signaling pathway in non-small cell lung cancer
Yingying Wang, Lu Meng, Shuyan Meng, Litang Huang, Shilan Luo, Xiaoting Wu & Xiaomei Gong
Article: 2203332
Published online: 02 May 2023
AbstractforFlotillin-1 enhances radioresistance through reducing radiation-induced DNA damage and promoting immune escape via STING signaling pathway in non-small cell lung cancer | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 4195 Views
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Article
CCL2 promotes lymphatic metastasis via activating RhoA and Rac1 pathway and predict prognosis to some extent in tongue cancer
Yuqing Dong, Shuning Zhang, Shuangyuan Zhao, Ming Xuan, Guiquan Zhu, Zhuang Zhang & Weihua Guo
Article: 2205342
Published online: 03 May 2023
AbstractforCCL2 promotes lymphatic metastasis via activating RhoA and Rac1 pathway and predict prognosis to some extent in tongue cancer | Full Text | References | PDF (7 MB) | EPUB
  • 3396 Views
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Open Access
Article
SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus
Wenwen Geng, Meiling Cao, Ke Dong, Junhua An & Haidong Gao
Article: 2206362
Published online: 11 May 2023
AbstractforSHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 2480 Views
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Open Access
Article
CSTF2T facilitates pancreatic adenocarcinoma growth and metastasis by elevating H3K4Me1 methylation of CALB2 via ASH2L
Wei Liu, Dongwei Hu, Jinjie Li, Qigang Xu, Zongjing Chen & Bo Xu
Article: 2216041
Published online: 07 Jun 2023
AbstractforCSTF2T facilitates pancreatic adenocarcinoma growth and metastasis by elevating H3K4Me1 methylation of CALB2 via ASH2L | Full Text | References | PDF (20.1 MB) | EPUB | Supplemental
  • 1644 Views
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Article
Exosome-transmitted hsa_circ_0012634 suppresses pancreatic ductal adenocarcinoma progression through regulating miR-147b/HIPK2 axis
Luoluo Wang, Xiang Wu, Yi Ruan, Xueming Zhang & Xinhua Zhou
Article: 2218514
Published online: 16 Jun 2023
AbstractforExosome-transmitted hsa_circ_0012634 suppresses pancreatic ductal adenocarcinoma progression through regulating miR-147b/HIPK2 axis | Full Text | References | PDF (7.3 MB) | EPUB | Supplemental
  • 2037 Views
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Review

Review Article
Targeting CDK9 with selective inhibitors or degraders in tumor therapy: an overview of recent developments
Lanshu Xiao, Yi Liu, Hui Chen & Lisong Shen
Article: 2219470
Published online: 05 Jun 2023
AbstractforTargeting CDK9 with selective inhibitors or degraders in tumor therapy: an overview of recent developments | Full Text | References | PDF (3.1 MB) | EPUB
  • 3679 Views
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Research Paper

Article
CX43 down-regulation promotes cell aggressiveness and 5-fluorouracil-resistance by attenuating cell stiffness in colorectal carcinoma
Yue Han, Haowei Wang, Hui Chen, Tianyuan Tan, Yiqing Wang, Hongjun Yang, Yanqing Ding & Shuang Wang
Article: 2221879
Published online: 21 Jun 2023
AbstractforCX43 down-regulation promotes cell aggressiveness and 5-fluorouracil-resistance by attenuating cell stiffness in colorectal carcinoma | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 1276 Views
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Article
Genomic profiling, prognosis, and potential interventional targets in young and old patients with cholangiocarcinoma
Junhua Wang, Yaoting Shi, Jianbo Chen, Juying Liu, Xiaotian Zhao, Jiaohui Pang, Ximin Sun, Yichen Tian, Qiuxiang Ou, Feng Xia & Yunjie Chen
Article: 2223375
Published online: 19 Jun 2023
AbstractforGenomic profiling, prognosis, and potential interventional targets in young and old patients with cholangiocarcinoma | Full Text | References | PDF (1.9 MB) | EPUB
  • 1728 Views
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Article
LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis
Huiyong Chen, Linhui Wang, Jingting Liu, Zihao Wan, Lin Zhou, Hongliang Liao & Renping Wan
Article: 2223377
Published online: 27 Jun 2023
AbstractforLncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis | Full Text | References | PDF (6.1 MB) | EPUB | Supplemental
  • 3594 Views
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Article
Molecular features, biological behaviors and clinical implications of m5C RNA methylation modification regulators in gastrointestinal cancers
Mengyao Zhan, Huan Song, Dan Tian, Qin Wen, Xinling Shi, Yuting Wang, Xuhua Mao & Jianming Wang
Article: 2223382
Published online: 18 Jun 2023
AbstractforMolecular features, biological behaviors and clinical implications of m5C RNA methylation modification regulators in gastrointestinal cancers | Full Text | References | PDF (17.1 MB) | EPUB | Supplemental
  • 1945 Views
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Article
PLK4 inhibitor exhibits antitumor effect and synergizes sorafenib via arresting cell cycle and inactivating Wnt/β-catenin pathway in anaplastic thyroid cancer
Wei Zhu & Bin Xie
Article: 2223383
Published online: 23 Jun 2023
AbstractforPLK4 inhibitor exhibits antitumor effect and synergizes sorafenib via arresting cell cycle and inactivating Wnt/β-catenin pathway in anaplastic thyroid cancer | Full Text | References | PDF (6.6 MB) | EPUB | Supplemental
  • 1602 Views
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Article
Preclinical evaluation of the CDK4/6 inhibitor palbociclib in combination with a PI3K or MEK inhibitor in colorectal cancer
Cha Len Lee, Mattia Cremona, Angela Farrelly, Julie A. Workman, Sean Kennedy, Razia Aslam, Aoife Carr, Stephen Madden, Brian O’Neill, Bryan T. Hennessy & Sinead Toomey
Article: 2223388
Published online: 16 Jun 2023
AbstractforPreclinical evaluation of the CDK4/6 inhibitor palbociclib in combination with a PI3K or MEK inhibitor in colorectal cancer | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 2091 Views
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Article
MiR-18a-5p attenuates HER2-positive breast cancer development by regulating PI3K/AKT pathway
Yongjun Liu & Hua Yang
Article: 2224512
Published online: 02 Jul 2023
AbstractforMiR-18a-5p attenuates HER2-positive breast cancer development by regulating PI3K/AKT pathway | Full Text | References | PDF (1.8 MB) | EPUB
  • 1700 Views
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Article
BTF3 promotes proliferation and glycolysis in hepatocellular carcinoma by regulating GLUT1
Peng Wang, Jianmin Sun, Chengming Sun, Haoran Zhao, YuBao Zhang & Jing Chen
Article: 2225884
Published online: 29 Jun 2023
AbstractforBTF3 promotes proliferation and glycolysis in hepatocellular carcinoma by regulating GLUT1 | Full Text | References | PDF (4.8 MB) | EPUB
  • 2160 Views
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Article
KLF4 targets RAB26 and decreases 5-FU resistance through inhibiting autophagy in colon cancer
Yu Zheng, Jiansheng Wu, Hong Chen, Dajia Lin, Hongyuan Chen, Junyin Zheng, Haoyun Xia, Liangxiang Huang & Changqing Zeng
Article: 2226353
Published online: 11 Jul 2023
AbstractforKLF4 targets RAB26 and decreases 5-FU resistance through inhibiting autophagy in colon cancer | Full Text | References | PDF (12.9 MB) | EPUB
  • 2404 Views
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Article
Targeting crosstalk of STAT3 between tumor-associated M2 macrophages and Tregs in colorectal cancer
Lili Huang, Yu Zhao, Mengying Shan, Sitong Wang, Jianhua Chen, Zhuqing Liu & Qing Xu
Article: 2226418
Published online: 28 Jun 2023
AbstractforTargeting crosstalk of STAT3 between tumor-associated M2 macrophages and Tregs in colorectal cancer | Full Text | References | PDF (11.3 MB) | EPUB
  • 2186 Views
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Article
MiR-128-1-5p inhibits cell proliferation and induces cell apoptosis via targeting PRKCQ in colorectal cancer
Qingan Jia, Xia Liao, Binghui Xu, Yufang Li & Lei Liang
Article: 2226421
Published online: 26 Jun 2023
AbstractforMiR-128-1-5p inhibits cell proliferation and induces cell apoptosis via targeting PRKCQ in colorectal cancer | Full Text | References | PDF (3.7 MB) | EPUB
  • 1228 Views
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Article
Apicidin confers promising therapeutic effect on acute myeloid leukemia cells via increasing QPCT expression
Lulu Liu, Haihui Liu, Lei Liu, Qian Huang, Chunyan Yang, Panpan Cheng, Saisai Ren, Jingjing Zhang, Mingxiao Yu, Xinying Ma, Wenjun Song, Lulu Chen, Hao Zhang, Mingtai Chen & Xianning Zhang
Article: 2228497
Published online: 28 Jun 2023
AbstractforApicidin confers promising therapeutic effect on acute myeloid leukemia cells via increasing QPCT expression | Full Text | References | PDF (6.6 MB) | EPUB | Supplemental
  • 1224 Views
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Article
Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair
Zhen Qian, Nannan Feng & Anke Geng
Article: 2229958
Published online: 05 Jul 2023
AbstractforTanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 1574 Views
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Article
VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma
Shuo Yang, Ping Zhou, Lelei Zhang, Xiangpeng Xie, Yuanyi Zhang, Kaida Bo, Jing Xue, Wei Zhang, Faxue Liao, Pengfei Xu, Yong Hu, Ruyu Yan, Dan Liu, Jun Chang & Kecheng Zhou
Article: 2230641
Published online: 05 Jul 2023
AbstractforVAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma | Full Text | References | PDF (9.4 MB) | EPUB | Supplemental
  • 2225 Views
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Article
RING box protein-1(RBX1), a key component of SCF E3 ligase, induced multiple myeloma cell drug-resistance though suppressing p27
Enfang Bao, Yu Zhou, Song He, Jie Tang, Yunhua He, Mengyuan Zhu, Chun Cheng & Yuchan Wang
Article: 2231670
Published online: 28 Aug 2023
AbstractforRING box protein-1(RBX1), a key component of SCF E3 ligase, induced multiple myeloma cell drug-resistance though suppressing p27 | Full Text | References | PDF (6.6 MB) | EPUB
  • 1124 Views
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Article
Developing and characterizing a two-layered safety switch for cell therapies
Filippo Rossignoli, Danielle Hoffman, Emaan Atif & Khalid Shah
Article: 2232146
Published online: 13 Jul 2023
AbstractforDeveloping and characterizing a two-layered safety switch for cell therapies | Full Text | References | PDF (2 MB) | EPUB
  • 1331 Views
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Article
Comparison of tumor growth assessment using GFP fluorescence and DiI labeling in a zebrafish xenograft model
Yaal Dryer, Joos Berghausen, Karen Creswell, Eric Glasgow & Tinatin I. Brelidze
Article: 2234140
Published online: 16 Jul 2023
AbstractforComparison of tumor growth assessment using GFP fluorescence and DiI labeling in a zebrafish xenograft model | Full Text | References | PDF (3.6 MB) | EPUB
  • 1377 Views
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Article
A feedback loop between lncRNA MALAT1 and DNMT1 promotes triple-negative breast cancer stemness and tumorigenesis
Yu Hu, Yuqiong He, Na Luo, Xin Li, Lei Guo & Kejing Zhang
Article: 2235768
Published online: 07 Aug 2023
AbstractforA feedback loop between lncRNA MALAT1 and DNMT1 promotes triple-negative breast cancer stemness and tumorigenesis | Full Text | References | PDF (7.6 MB) | EPUB | Supplemental
  • 1724 Views
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Article
SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis
Xiao-Wei Wang, Ying-Hao Jiang, Wei Ye, Chun-Fa Shao, Jian-Jin Xie & Xia Li
Article: 2235770
Published online: 14 Aug 2023
AbstractforSIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 1507 Views
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Article
Identification of USP29 as a key regulator of nucleotide biosynthesis in neuroblastoma through integrative analysis of multi-omics data
Ye Kang, Yahuan Yu, Yijia Liu, Yiwen Pan, Ru Zhang, Doudou Ren, Zeqiong Cai, Junpeng Ma, Xiaofan Xiong, Qi Zhang, Chengsheng Zhang & Rongfu Tu
Article: 2237200
Published online: 18 Jul 2023
AbstractforIdentification of USP29 as a key regulator of nucleotide biosynthesis in neuroblastoma through integrative analysis of multi-omics data | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 1716 Views
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Review

Review Article
The human microbiome and cancer: a diagnostic and therapeutic perspective
Shruthi Kandalai, Huapeng Li, Nan Zhang, Haidong Peng & Qingfei Zheng
Article: 2240084
Published online: 27 Jul 2023
AbstractforThe human microbiome and cancer: a diagnostic and therapeutic perspective | Full Text | References | PDF (1.5 MB) | EPUB
  • 4126 Views
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Retraction

Retraction
Statement of Retraction: A regulatory circuit of circ-MTO1/miR-17/QKI-5 inhibits the proliferation of lung adenocarcinoma
Article: 2240179
Published online: 03 Sep 2023
CitationforStatement of Retraction: A regulatory circuit of circ-MTO1/miR-17/QKI-5 inhibits the proliferation of lung adenocarcinoma | Full Text | PDF (139.6 KB) | EPUB
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Research Paper

Article
Ruangan Lidan decoction inhibits the growth and metastasis of liver cancer by downregulating miR-9-5p and upregulating PDK4
Tao Si, Liyin Huang, Ting Liang, Ping Huang, Hongyu Zhang, Mingmin Zhang & Xiaoling Zhou
Article: 2246198
Published online: 29 Sep 2023
AbstractforRuangan Lidan decoction inhibits the growth and metastasis of liver cancer by downregulating miR-9-5p and upregulating PDK4 | Full Text | References | PDF (8.6 MB) | EPUB | Supplemental
  • 1009 Views
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Open Access
Article
Nucleo-cytoplasmic shuttling of 14-3-3 epsilon carrying hnRNP C promotes autophagy
Manlan Guo, Minyi He, Yi Zhang, Weiwen Liu, Min Qi, Zhifeng Liu, Guozhong Yi, Shengze Deng, Yaomin Li, Xuegang Sun, Liang Zhao, Tengxiang Chen & Yawei Liu
Article: 2246203
Published online: 20 Aug 2023
AbstractforNucleo-cytoplasmic shuttling of 14-3-3 epsilon carrying hnRNP C promotes autophagy | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 1291 Views
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Article
CircSETD2 inhibits YAP1 by interaction with HuR during breast cancer progression
Lan Jing, Liu Yang, Cao Jianbo, Wan Yuqiu & Zhou Yehui
Article: 2246205
Published online: 22 Aug 2023
AbstractforCircSETD2 inhibits YAP1 by interaction with HuR during breast cancer progression | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 1044 Views
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Article
Transcription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma
Zhao-Xing Li, Ming-Chuang Sun, Kang Fang, Zi-Ying Zhao, Zhu-Yun Leng, Ze-Hua Zhang, Ai-Ping Xu, Yuan Chu, Li Zhang, Jingjing Lian, Tao Chen & Mei-Dong Xu
Article: 2246206
Published online: 21 Aug 2023
AbstractforTranscription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma | Full Text | References | PDF (6.8 MB) | EPUB | Supplemental
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Article
Mutant PIK3CA as a negative predictive biomarker for treatment with a highly selective PIM1 inhibitor in human colon cancer
Yoon Sun Park, Joseph kim, Yea Seong Ryu, Jai-Hee moon, Yu Jin shin, Jeong Hee kim, Seung-Woo hong, Soo-A jung, Seul lee, Seung-Mi kim, Dae Hee lee, Do Yeon kim, Hyeseon yun, Ji-Eun you, Dong Il yoon, Chul Hee kim, Dong-In koh & Dong-Hoon jin
Article: 2246208
Published online: 24 Aug 2023
AbstractforMutant PIK3CA as a negative predictive biomarker for treatment with a highly selective PIM1 inhibitor in human colon cancer | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Sinapine thiocyanate exhibited anti-colorectal cancer effects by inhibiting KRT6A/S100A2 axis
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Article: 2249170
Published online: 30 Aug 2023
AbstractforSinapine thiocyanate exhibited anti-colorectal cancer effects by inhibiting KRT6A/S100A2 axis | Full Text | References | PDF (8.7 MB) | EPUB
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N6-methyladenosine-regulated ADIRF impairs lung adenocarcinoma metastasis and serves as a potential prognostic biomarker
Yin Teng, Xiaohan Zhao, Yang Xi & Ninghua Fu
Article: 2249173
Published online: 12 Sep 2023
AbstractforN6-methyladenosine-regulated ADIRF impairs lung adenocarcinoma metastasis and serves as a potential prognostic biomarker | Full Text | References | PDF (8.9 MB) | EPUB | Supplemental
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The involvement of MALAT1-ALKBH5 signaling axis into proliferation and metastasis of human papillomavirus-positive cervical cancer
Suzhen Wu, Lili Liu, Huanying Xu, Qiaoling Zhu & Minhua Tan
Article: 2249174
Published online: 28 Aug 2023
AbstractforThe involvement of MALAT1-ALKBH5 signaling axis into proliferation and metastasis of human papillomavirus-positive cervical cancer | Full Text | References | PDF (12.6 MB) | EPUB | Supplemental
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Drug repurposing based on differentially expressed genes suggests drug combinations with possible synergistic effects in treatment of lung adenocarcinoma
Liora Yesharim & Shahram Teimourian
Article: 2253586
Published online: 14 Sep 2023
AbstractforDrug repurposing based on differentially expressed genes suggests drug combinations with possible synergistic effects in treatment of lung adenocarcinoma | Full Text | References | PDF (6 MB) | EPUB
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Article
A study on metabolic characteristics and metabolic markers of gastrointestinal tumors
Shan Cong, shanshan Bai, Minghao Zhang, yanfang Bi, yu Wang, shi Jin & hui He
Article: 2255369
Published online: 13 Sep 2023
AbstractforA study on metabolic characteristics and metabolic markers of gastrointestinal tumors | Full Text | References | PDF (7.5 MB) | EPUB | Supplemental
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Article
Role of human epidermal growth factor receptor 3 in treatment resistance of anaplastic lymphoma kinase translocated non-small cell lung cancer
Tiia J Honkanen, Milla E K Luukkainen & Jussi P Koivunen
Article: 2256906
Published online: 18 Sep 2023
AbstractforRole of human epidermal growth factor receptor 3 in treatment resistance of anaplastic lymphoma kinase translocated non-small cell lung cancer | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
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Article
Molecular profiles of different PD-L1 expression in patients with esophageal squamous cell carcinoma
Songchen Zhao, Xintong Hu, Peiwen Zhou, Ang Li, Liguo Chen, Duo Wang, Jiaxue He & Yanfang Jiang
Article: 2256927
Published online: 21 Sep 2023
AbstractforMolecular profiles of different PD-L1 expression in patients with esophageal squamous cell carcinoma | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
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Article
Hsa_circ_0119412 is a tumor promoter in hepatocellular carcinoma by inhibiting miR-526b-5p to upregulate STMN1
Song Wu, Tao Tang, Hongchi Zhou, Jing Huang, Xiaoliang Kang & Junli Zhang
Article: 2256951
Published online: 29 Sep 2023
AbstractforHsa_circ_0119412 is a tumor promoter in hepatocellular carcinoma by inhibiting miR-526b-5p to upregulate STMN1 | Full Text | References | PDF (5.1 MB) | EPUB
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Article
Dysregulation of the circ_0087502/miR-1179/TGFBR2 pathway supports gemcitabine resistance in pancreatic cancer
Mingliu Chen, Xinxiu Liu, Jinpeng Lu, Haiwen Teng, Chengui Yu, Yingchun Liu & Yansong Zheng
Article: 2258566
Published online: 16 Oct 2023
AbstractforDysregulation of the circ_0087502/miR-1179/TGFBR2 pathway supports gemcitabine resistance in pancreatic cancer | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
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Article
Function of m5C RNA methyltransferase NOP2 in high-grade serous ovarian cancer
Shimin Yang, Dongmei Zhou, Chunxiao Zhang, Jiangdong Xiang & Xiaowei Xi
Article: 2263921
Published online: 06 Oct 2023
AbstractforFunction of m5C RNA methyltransferase NOP2 in high-grade serous ovarian cancer | Full Text | References | PDF (7.2 MB) | EPUB | Supplemental
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Article
Phase II study of apatinib plus exemestane in estrogen receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer
Aihua Tan, Li Nong, Hongxue Wang, Yuxian Jia, Wuning Zhong, Fanghui Qin, Han Wang, Jing Tang, Yan Liu & Yongkui Lu
Article: 2265055
Published online: 13 Oct 2023
AbstractforPhase II study of apatinib plus exemestane in estrogen receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance
David J. Zahavi, Rossin Erbe, Yong-Wei Zhang, Theresa Guo, Zoe X. Malchiodi, Rachael Maynard, Alexander Lekan, Rosa Gallagher, Julia Wulfkuhle, Emanuel Petricoin, Sandra A. Jablonski, Elana J. Fertig & Louis M. Weiner
Article: 2269637
Published online: 25 Oct 2023
AbstractforAntibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Article
EGR1/LINC00839/SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells
Zunxian Wang, Bo Wei & Shuxia Ma
Article: 2270106
Published online: 20 Oct 2023
AbstractforEGR1/LINC00839/SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells | Full Text | References | PDF (5 MB) | EPUB | Supplemental
  • 841 Views
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Report

Report
Acquired resistance to crizotinib in novel CDK14-ALK and CLTC-ALK fusions of ALK-positive large B-cell lymphoma identified by next-generation sequencing
Yuxue Xia, Lu Zhang, Wenjuan He, Huaxiong Pan, Jun Fang & Guohui Cui
Article: 2271212
Published online: 31 Oct 2023
AbstractforAcquired resistance to crizotinib in novel CDK14-ALK and CLTC-ALK fusions of ALK-positive large B-cell lymphoma identified by next-generation sequencing | Full Text | References | PDF (1.9 MB) | EPUB
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Article
PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness
William S. Streitfeld, Annamarie C. Dalton, Breege V. Howley & Philip H. Howe
Article: 2271638
Published online: 06 Nov 2023
AbstractforPCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness | Full Text | References | PDF (6.3 MB) | EPUB
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Article
Combination therapy of niclosamide with gemcitabine inhibited cell proliferation and apoptosis via Wnt/β-catenin/c-Myc signaling pathway by inducing β-catenin ubiquitination in pancreatic cancer
Hyeon Woong Kang, Ju Hyun Kim, Da Eun Lee, Yun Sun Lee, Myeong Jin Kim, Hyung Sun Kim, SungSoon Fang, Bo Eun Lee, Kyung Jin Lee, Jongman Yoo, Hyo Jung Kim & Joon Seong Park
Article: 2272334
Published online: 02 Nov 2023
AbstractforCombination therapy of niclosamide with gemcitabine inhibited cell proliferation and apoptosis via Wnt/β-catenin/c-Myc signaling pathway by inducing β-catenin ubiquitination in pancreatic cancer | Full Text | References | PDF (3.8 MB) | EPUB
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Article
hsa_circ_0020378 regulating miR-339-3p/COL1A1 promotes osteosarcoma progression
Liang Liu & Wenze Huang
Article: 2274120
Published online: 18 Nov 2023
Abstractforhsa_circ_0020378 regulating miR-339-3p/COL1A1 promotes osteosarcoma progression | Full Text | References | PDF (5.2 MB) | EPUB
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Article
The efficacy of induction chemotherapy or adjuvant chemotherapy added to concurrent chemoradiotherapy in T3-4N0-1M0 nasopharyngeal carcinoma: a propensity score-matched analysis
Qiulu Zhong, Danjing Luo, Xiangde Li, Qinghua Du, Qianfu Liang, Wenqi Liu, Jian Li & Xiaodong Zhu
Article: 2274121
Published online: 15 Nov 2023
AbstractforThe efficacy of induction chemotherapy or adjuvant chemotherapy added to concurrent chemoradiotherapy in T3-4N0-1M0 nasopharyngeal carcinoma: a propensity score-matched analysis | Full Text | References | PDF (2.1 MB) | EPUB
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Article
MiR-597-5p inhibits carcinogenesis and macrophage recruitment in colitis-related colorectal cancer via reducing the expression of CXCL5
Shuo Li, Miao Yu, Xiuying Wang & Bingyuan Fei
Article: 2274122
Published online: 09 Nov 2023
AbstractforMiR-597-5p inhibits carcinogenesis and macrophage recruitment in colitis-related colorectal cancer via reducing the expression of CXCL5 | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
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Review

Review Article
Clinical application of molecular residual disease detection by circulation tumor DNA in solid cancers and a comparison of technologies: review article
Qiantong Dong, Chenbin Chen, Yuanbo Hu, Weiteng Zhang, Xinxin Yang, Yingxue Qi, Chan Zhu, Xiaodong Chen, Xian Shen & Weiping Ji
Article: 2274123
Published online: 13 Nov 2023
AbstractforClinical application of molecular residual disease detection by circulation tumor DNA in solid cancers and a comparison of technologies: review article | Full Text | References | PDF (788.6 KB) | EPUB
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Article
NAT10 promotes the tumorigenesis and progression of laryngeal squamous cell carcinoma through ac4C modification of FOXM1 mRNA
Zengpei Li, Dajun Li, Tianbin Yang & Chen Yao
Article: 2274143
Published online: 10 Nov 2023
AbstractforNAT10 promotes the tumorigenesis and progression of laryngeal squamous cell carcinoma through ac4C modification of FOXM1 mRNA | Full Text | References | PDF (4 MB) | EPUB
  • 977 Views
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Article
Higher PD-1/Tim-3 expression on IFN-γ+ T cells is associated with poor prognosis in patients with acute myeloid leukemia
Shuxin Huang, Yujie Zhao, Wenpu Lai, Jiaxiong Tan, Xue Zheng, Xianfeng Zha, Yangqiu Li & Shaohua Chen
Article: 2278229
Published online: 14 Nov 2023
AbstractforHigher PD-1/Tim-3 expression on IFN-γ+ T cells is associated with poor prognosis in patients with acute myeloid leukemia | Full Text | References | PDF (5 MB) | EPUB | Supplemental
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Article
CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells
Zibo Chen, Xi Liu, Masanori Kawakami, Xiuxia Liu, Allison Baker, Aayush Bhatawadekar, Liliya Tyutyunyk-Massey, Kedar Narayan & Ethan Dmitrovsky
Article: 2279241
Published online: 30 Nov 2023
AbstractforCDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
  • 1323 Views
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Article
miRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGFβ2 signaling pathway
Zelin Yang, Liang Yang, Zhenkai Sun, Yuxi Rong, Chenglian Bai, Qiaoxiang Dong & Lin Jian
Article: 2281459
Published online: 19 Nov 2023
AbstractformiRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGFβ2 signaling pathway | Full Text | References | PDF (5.2 MB) | EPUB | Supplemental
  • 739 Views
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Article
Mathematical modeling predicts pathways to successful implementation of combination TRAIL-producing oncolytic virus and PAC-1 to treat granulosa cell tumors of the ovary
Justin Le Sauteur-Robitaille, Powel Crosley, Mary Hitt, Adrianne L. Jenner & Morgan Craig
Article: 2283926
Published online: 27 Nov 2023
AbstractforMathematical modeling predicts pathways to successful implementation of combination TRAIL-producing oncolytic virus and PAC-1 to treat granulosa cell tumors of the ovary | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 859 Views
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Article
Lipopolysaccharide (LPS) stimulation of Pancreatic Ductal Adenocarcinoma (PDAC) and macrophages activates the NLRP3 inflammasome that influences the levels of pro-inflammatory cytokines in a co-culture model
Hariss G Paremes Sivam, Beek Yoke Chin, Sook Yee Gan, Jia Hao Ng, Agnes Gwenhure & Elaine Wan Ling Chan
Article: 2284857
Published online: 29 Nov 2023
AbstractforLipopolysaccharide (LPS) stimulation of Pancreatic Ductal Adenocarcinoma (PDAC) and macrophages activates the NLRP3 inflammasome that influences the levels of pro-inflammatory cytokines in a co-culture model | Full Text | References | PDF (2.9 MB) | EPUB
  • 1012 Views
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Article
Serum ferritin level is an effective prognostic factor for lung cancer immunotherapy
Fei Wang, Guodong Deng, Ning Liang, Pingping Hu, Kuo Liu, Tong Liu, Yang Li, Meng Yuan, Li Liu, Jian Xie, Lili Qiao, Fengjun Liu & Jiandong Zhang
Article: 2285367
Published online: 30 Nov 2023
AbstractforSerum ferritin level is an effective prognostic factor for lung cancer immunotherapy | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1407 Views
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Research Paper

Article
Clinical significance of WT1 in the evaluation of therapeutic effect and prognosis of non-M3 acute myeloid leukemia
Tingyu Yu, Qian Zhan, Xinyu Yan, Xiaohua Luo, Xin Wang, Xiaoqiong Tang, Hongbin Zhang, Zesong Yang, Jianbin Chen, Lin Liu & Li Wang
Article: 2285801
Published online: 30 Nov 2023
AbstractforClinical significance of WT1 in the evaluation of therapeutic effect and prognosis of non-M3 acute myeloid leukemia | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 1002 Views
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Article
Revealing the inhibitory effect of VASH1 on ovarian cancer from multiple perspectives
Yan Li, Liang Meng & Ge Lou
Article: 2285817
Published online: 27 Nov 2023
AbstractforRevealing the inhibitory effect of VASH1 on ovarian cancer from multiple perspectives | Full Text | References | PDF (4.9 MB) | EPUB
  • 667 Views
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Article
Aldolase A promotes cervical cancer cell radioresistance by regulating the glycolysis and DNA damage after irradiation
Junying Zhou, Ningjing Lei, Bo Qin, Mengyu Chen, Shuai Gong, Hao Sun, Luojie Qiu, Fengling Wu, Ruixia Guo, Qian Ma, Yong Li & Lei Chang
Article: 2287128
Published online: 27 Nov 2023
AbstractforAldolase A promotes cervical cancer cell radioresistance by regulating the glycolysis and DNA damage after irradiation | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 903 Views
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Article
HSF1 is involved in immunotherapeutic response through regulating APOJ/STAT3-mediated PD-L1 expression in hepatocellular carcinoma
Hongxia Cheng, Sikai Wang, Aidan Huang, Jing Ma, Dongmei Gao, Miaomiao Li, Huaping Chen & Kun Guo
Pages: 1-9
Published online: 08 Dec 2022
AbstractforHSF1 is involved in immunotherapeutic response through regulating APOJ/STAT3-mediated PD-L1 expression in hepatocellular carcinoma | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 3868 Views
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