MiR-378a-5p exerts a radiosensitizing effect on CRC through LRP8/β-catenin axis

References

• Brody H. Colorectal cancer. Nature. 2015;521(7551):S1. doi:10.1038/521S1a.
   PubMed Web of Science ®Google Scholar
• Lech G, Slotwinski R, Slodkowski M, Krasnodebski IW. Colorectal cancer tumour markers and biomarkers: recent therapeutic advances. World J Gastroenterol. 2016;22(5):1745–14. doi:10.3748/wjg.v22.i5.1745.
   PubMed Web of Science ®Google Scholar
• Balchen V, Simon K. Colorectal cancer development and advances in screening. Clin Interv Aging. 2016;11:967–76. doi:10.2147/CIA.S109285.
   PubMed Web of Science ®Google Scholar
• Kobiela J, Spychalski P, Marvaso G, Ciardo D, Dell’acqua V, Kraja F, Błażyńska-Spychalska A, Łachiński AJ, Surgo A, Glynne-Jones R, et al. Ablative stereotactic radiotherapy for oligometastatic colorectal cancer: systematic review. Crit Rev Oncol Hematol. 2018;129:91–101. doi:10.1016/j.critrevonc.2018.06.005.
   PubMed Web of Science ®Google Scholar
• Chavali LB, Llanos AAM, Yun JP, Hill SM, Tan XL, Zhang L. Radiotherapy for patients with resected tumor deposit–positive colorectal cancer: a surveillance, epidemiology, and end results–based population study. Arch Pathol Lab Med. 2018;142(6):721–729. doi:10.5858/arpa.2017-0099-OA.
   PubMed Web of Science ®Google Scholar
• Liu N, Cui W, Jiang X, Zhang Z, Gnosa S, Ali Z, Jensen L, Jönsson J-I, Blockhuys S, Lam EWF, et al. The critical role of dysregulated RhoB signaling pathway in radioresistance of colorectal cancer. Int J Radiat Oncol Biol Phys. 2019;104(5):1153–64. doi:10.1016/j.ijrobp.2019.04.021.
   PubMed Web of Science ®Google Scholar
• Na YJ, Kim BR, Kim JL, Kang S, Jeong YA, Park SH, Jo MJ, Kim J-Y, Kim HJ, Oh SC, et al. Deficiency of 15-LOX-1 induces radioresistance through downregulation of MacroH2A2 in colorectal cancer. Cancers Basel. 2019;11(11):11. doi:10.3390/cancers11111776.
   Web of Science ®Google Scholar
• Park SY, Lee CJ, Choi JH, Kim JH, Kim JW, Kim JY, Nam JS. The JAK2/STAT3/CCND2 Axis promotes colorectal cancer stem cell persistence and radioresistance. J Exp Clin Cancer Res. 2019;38(1):399. doi:10.1186/s13046-019-1405-7.
   PubMed Web of Science ®Google Scholar
• Yang P, Yang Y, An W, Xu J, Zhang G, Jie J, Zhang Q. The long noncoding RNA-ROR promotes the resistance of radiotherapy for human colorectal cancer cells by targeting the p53/miR-145 pathway. J of Gastro and Hepatol. 2017;32(4):837–845. doi:10.1111/jgh.13606.
   PubMed Web of Science ®Google Scholar
• Wang G, Li Z, Zhao Q, Zhu Y, Zhao C, Li X, MA Z, LI X, ZHANG Y. LincRNA-p21 enhances the sensitivity of radiotherapy for human colorectal cancer by targeting the Wnt/β-catenin signaling pathway. Oncol Rep. 2014;31(4):1839–1845. doi:10.3892/or.2014.3047.
   PubMed Web of Science ®Google Scholar
• Yang XD, Xu XH, Zhang SY, Wu Y, Xing CG, Ru G, Xu HT, Cao JP. Role of miR-100 in the radioresistance of colorectal cancer cells. Am J Cancer Res. 2015;5(2):545–559.
   PubMed Web of Science ®Google Scholar
• Zheng L, Zhang Y, Liu Y, Zhou M, Lu Y, Yuan L, Zhang C, Hong M, Wang S, Li X, et al. MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer. J Transl Med. 2015;13(1):252. doi:10.1186/s12967-015-0592-z.
   PubMedGoogle Scholar
• Zhu Y, Wang C, Becker SA, Hurst K, Nogueira LM, Findlay VJ, Camp ER. miR-145 antagonizes SNAI1-mediated stemness and radiation resistance in colorectal cancer. Mol Ther. 2018;26(3):744–754. doi:10.1016/j.ymthe.2017.12.023.
   PubMed Web of Science ®Google Scholar
• Pan X, Zhao L, Quan J, Liu K, Lai Y, Li Z, Zhang Z, Xu J, Xu W, Guan X, et al. MiR-378a-5p acts as a tumor suppressor in renal cell carcinoma and is associated with the good prognosis of patients. Am J Transl Res. 2019;11(4):2207–2218.
   PubMed Web of Science ®Google Scholar
• Nadeem U, Ye G, Salem M, Peng C. MicroRNA-378a-5p targets cyclin G2 to inhibit fusion and differentiation in BeWo cells. Biol Reprod. 2014;91(3):76. doi:10.1095/biolreprod.114.119065.
   PubMed Web of Science ®Google Scholar
• Li H, Dai S, Zhen T, Shi H, Zhang F, Yang Y, Kang L, Liang Y, Han A. Clinical and biological significance of miR-378a-3p and miR-378a-5p in colorectal cancer. Eur J Cancer. 2014;50(6):1207–1221. doi:10.1016/j.ejca.2013.12.010.
   PubMed Web of Science ®Google Scholar
• Emons G, Spitzner M, Reineke S, Moller J, Auslander N, Kramer F, Hu Y, Beissbarth T, Wolff HA, Rave-Fränk M, et al. Chemoradiotherapy resistance in colorectal cancer cells is mediated by Wnt/β-catenin signaling. Mol Cancer Res. 2017;15(11):1481–1490. doi:10.1158/1541-7786.MCR-17-0205.
   PubMed Web of Science ®Google Scholar
• Lin CC, Lo MC, Moody R, Jiang H, Harouaka R, Stevers N, Tinsley S, Gasparyan M, Wicha M, Sun D, et al. Targeting LRP8 inhibits breast cancer stem cells in triple-negative breast cancer. Cancer Lett. 2018;438:165–73. doi:10.1016/j.canlet.2018.09.022.
   PubMed Web of Science ®Google Scholar
• Zhao L, Bode AM, Cao Y, Dong Z. Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity. Carcinogen. 2012;33(11):2220–7. doi:10.1093/carcin/bgs235.
   PubMed Web of Science ®Google Scholar
• Wang XC, Wang W, Zhang ZB, Zhao J, Tan XG, Luo JC. Overexpression of miRNA-21 promotes radiation-resistance of non-small cell lung cancer. Radiat Oncol. 2013;8(1):146. doi:10.1186/1748-717X-8-146.
   PubMedGoogle Scholar
• Zhang Y, Zheng L, Ding Y, Li Q, Wang R, Liu T, Sun Q, Yang H, Peng S, Wang W, et al. MiR-20a induces cell radioresistance by activating the PTEN/PI3K/Akt signaling pathway in hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 2015;92(5):1132–40. doi:10.1016/j.ijrobp.2015.04.007.
   PubMed Web of Science ®Google Scholar
• Tian Y, Tian Y, Tu Y, Zhang G, Zeng X, Lin J, Ai M, Mao Z, Zheng R, Yuan Y, et al. microRNA-124 inhibits stem-like properties and enhances radiosensitivity in nasopharyngeal carcinoma cells via direct repression of expression of JAMA. J Cell Mol Med. 2020;24(17):9533–44. doi:10.1111/jcmm.15177.
   PubMed Web of Science ®Google Scholar
• Afshar S, Najafi R, Sedighi Pashaki A, Sharifi M, Nikzad S, Gholami MH, Khoshghadam A, Amini R, Karimi J, Saidijam M, et al. MiR-185 enhances radiosensitivity of colorectal cancer cells by targeting IGF1R and IGF2. Biomed Pharmacother. 2018;106:763–9. doi:10.1016/j.biopha.2018.07.002.
   PubMed Web of Science ®Google Scholar
• Gu C, Cai J, Xu Z, Zhou S, Ye L, Yan Q, Zhang Y, Fang Y, Liu Y, Tu C, et al. MiR-532-3p suppresses colorectal cancer progression by disrupting the ETS1/TGM2 axis-mediated Wnt/β-catenin signaling. Cell Death Dis. 2019;10(10):739. doi:10.1038/s41419-019-1962-x.
   PubMedGoogle Scholar
• Wu Y, Pu N, Su W, Yang X, Xing C. Downregulation of miR-1 in colorectal cancer promotes radioresistance and aggressive phenotypes. J Cancer. 2020;11(16):4832–40. doi:10.7150/jca.44753.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zheng L, Huang J, Gao F, Lin X, He L, Li D, Li Z, Ding Y, Chen L, et al. MiR-124 radiosensitizes human colorectal cancer cells by targeting PRRX1. PloS ONE. 2014;9(4):e93917. doi:10.1371/journal.pone.0093917.
   PubMed Web of Science ®Google Scholar
• Machado IF, Teodoro JS, Palmeira CM, Rolo AP. miR-378a: a new emerging microRNA in metabolism. Cell Mol Life Sci. 2020;77(10):1947–58. doi:10.1007/s00018-019-03375-z.
   PubMed Web of Science ®Google Scholar
• Yang R, Wei M, Yang F, Sheng Y, Ji L. Diosbulbin B induced G2/M cell cycle arrest in hepatocytes by miRNA-186-3p and miRNA-378a-5p-mediated the decreased expression of CDK1. Toxicol Appl Pharmacol. 2018;357:1–9. doi:10.1016/j.taap.2018.08.016.
   PubMed Web of Science ®Google Scholar
• Maire V, Mahmood F, Rigaill G, Ye M, Brisson A, Nemati F, Gentien D, Tucker GC, Roman‐Roman S, Dubois T, et al. LRP8 is overexpressed in estrogen-negative breast cancers and a potential target for these tumors. Cancer Med. 2019;8(1):325–36. doi:10.1002/cam4.1923.
   PubMed Web of Science ®Google Scholar
• Liu S, Fan W, Gao X, Huang K, Ding C, Ma G, Yan L, Song S. Estrogen receptor alpha regulates the Wnt/β-catenin signaling pathway in colon cancer by targeting the NOD-like receptors. Cell Signal. 2019;61:86–92. doi:10.1016/j.cellsig.2019.05.009.
   PubMed Web of Science ®Google Scholar
• Zhang J, Zhang X, Zhang L, Zhou F, van Dinther M, Ten Dijke P. LRP8 mediates Wnt/β-catenin signaling and controls osteoblast differentiation. J Bone Miner Res. 2012;27(10):2065–2074. doi:10.1002/jbmr.1661.
   PubMed Web of Science ®Google Scholar
• Cui Z, Liu QL, Sun SQ, Jiao K, Liu DR, Zhou XC, Huang L. MiR-378a-5p inhibits angiogenesis of oral squamous cell carcinoma by targeting KLK4. Neoplasma. 2020;67(1):85–92. doi:10.4149/neo_2019_190306N191.
   PubMed Web of Science ®Google Scholar
• Cheng X, Xu X, Chen D, Zhao F, Wang W. Therapeutic potential of targeting the Wnt/beta-catenin signaling pathway in colorectal cancer. Biomed Pharmacother. 2019;110:473–481. doi:10.1016/j.biopha.2018.11.082.
   PubMed Web of Science ®Google Scholar
• Jun S, Jung YS, Suh HN, Wang W, Kim MJ, Oh YS, Lien EM, Shen X, Matsumoto Y, McCrea PD, et al. LIG4 mediates wnt signalling-induced radioresistance. Nat Commun. 2016;7(1):10994. doi:10.1038/ncomms10994.
   PubMedGoogle Scholar
• Shi L, Xi J, Xu X, Peng B, Zhang B. MiR-148a suppressed cell invasion and migration via targeting WNT10b and modulating beta-catenin signaling in cisplatin-resistant colorectal cancer cells. Biomed Pharmacother. 2019;109:902–909. doi:10.1016/j.biopha.2018.10.080.
   PubMed Web of Science ®Google Scholar
• Feng H, Zhao JK, Schiergens TS, Wang PX, Ou BC, Al-Sayegh R, Li M-L, Lu A-G, Yin S, Thasler WE, et al. Bone marrow-derived mesenchymal stromal cells promote colorectal cancer cell death under low-dose irradiation. Br J Cancer. 2018;118(3):353–65. doi:10.1038/bjc.2017.415.
   PubMed Web of Science ®Google Scholar
• Ochiai S, Nishida Y, Higuchi Y, Morita D, Makida K, Seki T, Ikuta K, Imagama S. Short-range UV-LED irradiation in postmenopausal osteoporosis using ovariectomized mice. Sci Rep. 2021;11(1):7875. doi:10.1038/s41598-021-86730-0.
   PubMed Web of Science ®Google Scholar
• vMeyer AV, Klein D, de Leve S, Szymonowicz K, Stuschke M, Robson SC, Jendrossek V, Wirsdörfer F. Host CD39 deficiency affects radiation-induced tumor growth delay and aggravates radiation-induced normal tissue toxicity. Front Oncol. 2020;10:554883. doi:10.3389/fonc.2020.554883.
   PubMed Web of Science ®Google Scholar