Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapy

References

• Malard F, Mohty M. Acute lymphoblastic leukaemia. Lancet. 2020 Apr 4; 39510230: 1146–10. 10.1016/S0140-6736(19)33018-1.
   PubMed Web of Science ®Google Scholar
• Karantanou C, Minciacchi VR, Kumar R, Azimpour AI, Zanetti C, Karantanou C, Minka W, Minciacchi VR, Kowarz E, Meister M, et al. The differential role of the lipid raft-associated protein flotillin 2 for progression of myeloid leukemia. Blood Adv. 2022 Aug 31; 612:3611–3624. 10.1182/bloodadvances.2021005992.
   PubMed Web of Science ®Google Scholar
• Gibson LF. Survival of B lineage leukemic cells: signals from the bone marrow microenvironment. Leuk Lymphoma. 2002Jan, 431: 19–27. 10.1080/10428190210188.
   PubMed Web of Science ®Google Scholar
• Cahu X, Calvo J, Poglio S, Prade N, Colsch B, Arcangeli M-L, Leblanc T, Petit A, Baleydier F, Baruchel A, et al. Bone marrow sites differently imprint dormancy and chemoresistance to T-cell acute lymphoblastic leukemia. Blood Adv. 2017 Sep 12; 120:1760–1772. 10.1182/bloodadvances.2017004960.
   PubMed Web of Science ®Google Scholar
• Simioni C, Conti I, Varano G, Brenna C, Costanzi E, Neri LM. The complexity of the tumor microenvironment and its role in acute lymphoblastic leukemia: implications for therapies. Front Oncol. 2021; 11:673506. doi:10.3389/fonc.2021.673506.
   PubMed Web of Science ®Google Scholar
• Kokkaliaris KD, Scadden DT. Cell interactions in the bone marrow microenvironment affecting myeloid malignancies. Blood Adv. 2020 Aug 11; 415: 3795–3803. 10.1182/bloodadvances.2020002127.
   PubMed Web of Science ®Google Scholar
• Meyer LK, Hermiston ML. The bone marrow microenvironment as a mediator of chemoresistance in acute lymphoblastic leukemia. Cancer Drug Resist. 2019; 2(4):1164–1177. doi:10.20517/cdr.2019.63.
   PubMedGoogle Scholar
• Shipounova IN, Petinati NA, Bigildeev AE, Drize NJ, Sorokina TV, Kuzmina LA, Parovichnikova EN, Savchenko VG. Alterations of the bone marrow stromal microenvironment in adult patients with acute myeloid and lymphoblastic leukemias before and after allogeneic hematopoietic stem cell transplantation. Leuk Lymphoma. 2017Feb, 582: 408–417. 10.1080/10428194.2016.1187277.
   PubMed Web of Science ®Google Scholar
• Park SH, Lee MJ, Park CJ, Jang S, Seo E-J, Im H-J, Seo J-J. Bone marrow recovery of hematopoietic stem cells and microenvironment after chemotherapy in childhood acute lymphoblastic leukemia: consecutive observations according to chemotherapy schedule. Pediatr Hematol Oncol. 2019May, 364: 222–235. 10.1080/08880018.2019.1623354.
   PubMed Web of Science ®Google Scholar
• Fallati A, Di Marzo N, D’Amico G, Dander E. Mesenchymal stromal cells (MSCs): an ally of B-Cell acute lymphoblastic leukemia (B-ALL) cells in disease maintenance and progression within the bone marrow hematopoietic niche. Cancers Basel. 2022 Jul 6; 1414: 3303. 10.3390/cancers14143303.
   PubMed Web of Science ®Google Scholar
• Wang J, Liu X, Qiu Y, Shi Y, Cai J, Wang B, Wei X, Ke Q, Sui X, Wang Y, et al. Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells. J Hematol Oncol. 2018 Jan 22; 111:11. 10.1186/s13045-018-0554-z.
   PubMedGoogle Scholar
• Wang L, Zhang H, Wang S, Chen X, Su J. Bone marrow adipocytes: a critical player in the bone marrow microenvironment. Front Cell Dev Biol. 2021; 9:770705. doi:10.3389/fcell.2021.770705.
   PubMed Web of Science ®Google Scholar
• Zinngrebe J, Debatin KM, Fischer-Posovszky P. Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders? Leukemia. 2020Sep, 349: 2305–2316. 10.1038/s41375-020-0886-x.
   PubMed Web of Science ®Google Scholar
• Shafat MS, Oellerich T, Mohr S, Robinson SD, Edwards DR, Marlein CR, Piddock RE, Fenech M, Zaitseva L, Abdul-Aziz A, et al. Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment. Blood. 2017 Mar 9; 12910:1320–1332. 10.1182/blood-2016-08-734798.
   PubMed Web of Science ®Google Scholar
• Liu H, Zhai Y, Zhao W, Wan Y, Lu W, Yang S, Yu Y, Wei Y, Li Z, Shi J, et al. Consolidation chemotherapy prevents relapse by indirectly regulating bone marrow adipogenesis in patients with acute myeloid leukemia. Cell Physiol Biochem. 2018; 45(6):2389–2400. doi:10.1159/000488225.
   PubMedGoogle Scholar
• Zhang L, Zhao Q, Cang H, Wang Z, Hu X, Pan R, Yang Y, Chen Y. Acute myeloid leukemia cells educate mesenchymal stromal cells toward an adipogenic differentiation propensity with leukemia promotion capabilities. Adv Sci (Weinh). 2022Jun, 916: 2105811. 10.1002/advs.202105811.
   PubMedGoogle Scholar
• Ehsanipour EA, Sheng X, Behan JW, Wang X, Butturini A, Avramis VI, Mittelman SD. Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine. Cancer Res. 2013 May 15; 7310:2998–3006. 10.1158/0008-5472.CAN-12-4402.
   PubMed Web of Science ®Google Scholar
• Lu Z, Xie J, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJS, et al. Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation. Nat Med. 2017Jan; 231: 79–90. 10.1038/nm.4252.
   PubMed Web of Science ®Google Scholar
• Jiang Z, Qin L, Tang Y, Liao R, Shi J, He B, Li S, Zheng D, Cui Y, Wu Q, et al. Human induced-T-to-natural killer cells have potent anti-tumour activities. Biomark Res. 2022 Mar 24; 101:13. 10.1186/s40364-022-00358-4.
   PubMed Web of Science ®Google Scholar
• Xiao Y, Jiang Z, Li Y, Ye W, Jia B, Zhang M, Xu Y, Wu D, Lai L, Chen Y, et al. ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells. Haematologica. 2015; 100(5):585–594. doi:10.3324/haematol.2014.118612.
   PubMed Web of Science ®Google Scholar
• Jiang Z, Wu D, Ye W, Weng J, Lai P, Shi P, Guo X, Huang G, Deng Q, Tang Y, et al. Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia. Oncotarget. 2017 Dec 5; 863:106382–106392. 10.18632/oncotarget.22466.
   PubMedGoogle Scholar
• Li J, Zhang N, Huang X, Xu J, Fernandes JC, Dai K, Zhang X. Dexamethasone shifts bone marrow stromal cells from osteoblasts to adipocytes by C/EBPalpha promoter methylation. Cell Death Disease. 2013 Oct 3; 410:e832. 10.1038/cddis.2013.348.
   PubMedGoogle Scholar
• Ma Z, Zhao X, Deng M, Huang Z, Wang J, Wu Y, Cui D, Liu Y, Liu R, Ouyang G, et al. Bone marrow mesenchymal stromal cell-derived periostin promotes B-ALL progression by modulating CCL2 in leukemia cells. Cell Rep. 2019 Feb 5; 266:1533–1543.e4. 10.1016/j.celrep.2019.01.034.
   PubMed Web of Science ®Google Scholar
• Pan C, Fang Q, Liu P, Ma D, Cao S, Zhang L, Chen Q, Hu T, Wang J. Mesenchymal stem cells with cancer-associated fibroblast-like phenotype stimulate SDF-1/CXCR4 axis to enhance the growth and invasion of B-Cell acute lymphoblastic leukemia cells through cell-to-cell communication. Front Cell Dev Biol. 2021; 9:708513. doi:10.3389/fcell.2021.708513.
   PubMed Web of Science ®Google Scholar
• Batsivari A, Haltalli MLR, Passaro D, Pospori C, Lo Celso C, Bonnet D. Dynamic responses of the haematopoietic stem cell niche to diverse stresses. Nat Cell Biol. 2020Jan, 221: 7–17. 10.1038/s41556-019-0444-9.
   PubMed Web of Science ®Google Scholar
• Baryawno N, Przybylski D, Kowalczyk MS, Kfoury Y, Severe N, Gustafsson K, Kokkaliaris KD, Mercier F, Tabaka M, Hofree M, et al. A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia. Cell. 2019 Jun 13; 1777:1915–1932.e16. 10.1016/j.cell.2019.04.040.
   PubMed Web of Science ®Google Scholar
• Heydt Q, Xintaropoulou C, Clear A, Austin M, Pislariu I, Miraki-Moud F, Cutillas P, Korfi K, Calaminici M, Cawthorn W, et al. Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence. Nat Commun. 2021 Sep 17; 121:5507. 10.1038/s41467-021-25540-4.
   PubMed Web of Science ®Google Scholar
• Li SN, Wu JF. TGF-beta/SMAD signaling regulation of mesenchymal stem cells in adipocyte commitment. Stem Cell Res Ther. 2020 Jan 29; 111: 41. 10.1186/s13287-020-1552-y.
   PubMed Web of Science ®Google Scholar
• Li Y, Jin D, Xie W, Wen L, Chen W, Xu J, Ding J, Ren D. PPAR-γ and wnt regulate the differentiation of MSCs into adipocytes and osteoblasts respectively. Curr Stem Cell Res Ther. 2018 Feb 23; 133: 185–192. 10.2174/1574888X12666171012141908.
   PubMed Web of Science ®Google Scholar
• Tabe Y, Konopleva M, Andreeff M. Fatty acid metabolism, bone marrow adipocytes, and AML. Front Oncol. 2020; 10:155. doi:10.3389/fonc.2020.00155.
   PubMed Web of Science ®Google Scholar
• Tucci J, Chen T, Margulis K, Orgel E, Paszkiewicz RL, Cohen MD, Oberley MJ, Wahhab R, Jones AE, Divakaruni AS, et al. Adipocytes provide fatty acids to acute lymphoblastic leukemia cells. Front Oncol. 2021; 11:665763. doi:10.3389/fonc.2021.665763.
   PubMed Web of Science ®Google Scholar
• Boyd AL, Reid JC, Salci KR, Aslostovar L, Benoit YD, Shapovalova Z, Nakanishi M, Porras DP, Almakadi M, Campbell CJV, et al. Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche. Nat Cell Biol. 2017Nov; 1911: 1336–1347. 10.1038/ncb3625.
   PubMed Web of Science ®Google Scholar
• Yokota T, Meka CS, Kouro T, Medina KL, Igarashi H, Takahashi M, Oritani K, Funahashi T, Tomiyama Y, Matsuzawa Y, et al. Adiponectin, a fat cell product, influences the earliest lymphocyte precursors in bone marrow cultures by activation of the cyclooxygenase-prostaglandin pathway in stromal cells. J Immunol. 2003 Nov 15; 17110:5091–9. 10.4049/jimmunol.171.10.5091.
   PubMed Web of Science ®Google Scholar
• Majumdar MK, Thiede MA, Haynesworth SE, Bruder SP, Gerson SL. Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J Hematother Stem Cell Res. 2000Dec, 96: 841–848. 10.1089/152581600750062264.
   PubMedGoogle Scholar
• Weroha SJ, Haluska P. The insulin-like growth factor system in cancer. Endocrinol Metab Clin North Am. 2012Jun; 412: 335–50. vi. 10.1016/j.ecl.2012.04.014.
   PubMed Web of Science ®Google Scholar
• Touw I, Pouwels K, van Agthoven T, van Gurp R, Budel L, Hoogerbrugge H, Delwel R, Goodwin R, Namen A, Lowenberg B, et al. Interleukin-7 is a growth factor of precursor B and T acute lymphoblastic leukemia. Blood. 1990 Jun 1; 7511:2097–101. 10.1182/blood.V75.11.2097.2097.
   PubMed Web of Science ®Google Scholar
• Li Y, Shi Y, McCaw L, Li Y-J, Zhu F, Gorczynski R, Duncan GS, Yang B, Ben-David Y, Spaner DE, et al. Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A. Blood. 2015 Aug 6; 1266:766–78. 10.1182/blood-2014-12-618678.
   PubMed Web of Science ®Google Scholar