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Research paper

BRG1 promotes liver cancer cell proliferation and metastasis by enhancing mitochondrial function and ATP5A1 synthesis through TOMM40

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Article: 2375440 | Received 16 Feb 2024, Accepted 28 Jun 2024, Published online: 08 Jul 2024

References

  • Kulik L, El-Serag HB. Epidemiology and management of hepatocellular carcinoma. Gastroenterology. 2019;156(2):477–91.e471. doi:10.1053/j.gastro.2018.08.065.
  • Villanueva A, Longo DL. Hepatocellular carcinoma. N Engl J Med. 2019;380(15):1450–15. doi:10.1056/NEJMra1713263.
  • Vogel A, Meyer T, Sapisochin G, Salem R, Saborowski A. Hepatocellular carcinoma. Lancet (Lond, Engl). 2022;400(10360):1345–62. doi:10.1016/S0140-6736(22)01200-4.
  • Frenette C. Advances in hepatocellular carcinoma. Clin Liver Dis. 2020;24(4):xiii–xiv. doi:10.1016/j.cld.2020.08.014.
  • Piñero F, Dirchwolf M, Pessôa MG. Biomarkers in hepatocellular carcinoma: diagnosis, prognosis and treatment response assessment. Cells. 2020;9(6):1370. doi:10.3390/cells9061370.
  • Galle PR, Dufour JF, Peck-Radosavljevic M, Trojan J, Vogel A. Systemic therapy of advanced hepatocellular carcinoma. Future Oncol (Lond, Engl). 2021;17(10):1237–51. doi:10.2217/fon-2020-0758.
  • Sugawara Y, Hibi T. Surgical treatment of hepatocellular carcinoma. Bioscience trends. Biosci Trends. 2021;15(3):138–41. doi:10.5582/bst.2021.01094.
  • Shibata T. Genomic landscape of hepatocarcinogenesis. J Hum Genet. 2021;66(9):845–51. doi:10.1038/s10038-021-00928-8.
  • Takeda H, Takai A, Eso Y, Takahashi K, Marusawa H, Seno H. Genetic landscape of multistep hepatocarcinogenesis. Cancers. 2022;14(3):568. doi:10.3390/cancers14030568.
  • Javan H, Dayyani F, Abi-Jaoudeh N. Therapy in advanced hepatocellular carcinoma. Semin Intervent Radiol. 2020;37(5):466–74. doi:10.1055/s-0040-1719187.
  • Hsu CL, Ou DL, Bai LY, Chen C-W, Lin L, Huang S-F, Cheng A-L, Jeng Y-M, Hsu C. Exploring markers of exhausted CD8 T Cells to predict response to immune checkpoint inhibitor therapy for hepatocellular carcinoma. Liver Cancer. 2021;10(4):346–59. doi:10.1159/000515305.
  • Singh A, Beechinor RJ, Huynh JC, Li D, Dayyani F, Valerin JB, Hendifar A, Gong J, Cho M. Immunotherapy updates in advanced hepatocellular carcinoma. Cancers. 2021;13(9):2164. doi:10.3390/cancers13092164.
  • Xing R, Gao J, Cui Q, Wang Q. Strategies to improve the antitumor effect of immunotherapy for hepatocellular carcinoma. Front Immunol. 2021;12:783236. doi:10.3389/fimmu.2021.783236.
  • Giles KA, Gould CM, Achinger-Kawecka J, Page SG, Kafer GR, Rogers S, Luu P-L, Cesare AJ, Clark SJ, Taberlay PC, et al. BRG1 knockdown inhibits proliferation through multiple cellular pathways in prostate cancer. Clin Epigenetics. 2021;13(1):37. doi:10.1186/s13148-021-01023-7.
  • Sobczak M, Strachowska M, Robaszkiewicz A. Contribution of BRG1-dependent SWI/SNF complexes to determining the phenotype of cancer cell. Postepy Biochemii. 2020;66(1):10–18. doi:10.18388/pb.2020_312.
  • Mardinian K, Adashek JJ, Botta GP, Kato S, Kurzrock R. SMARCA4: implications of an altered chromatin-remodeling gene for cancer development and therapy. Mol Cancer Ther. 2021;20(12):2341–51. doi:10.1158/1535-7163.MCT-21-0433.
  • Wu Q, Lian JB, Stein JL, Stein GS, Nickerson JA, Imbalzano AN. The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer. Epigenomics. 2017;9(6):919–31. doi:10.2217/epi-2017-0034.
  • Dagogo-Jack I, Schrock AB, Kem M, Jessop N, Lee J, Ali SM, Ross JS, Lennerz JK, Shaw AT, Mino-Kenudson M, et al. Clinicopathologic Characteristics of BRG1-Deficient NSCLC. J Thorac Oncol. 2020;15(5):766–76. doi:10.1016/j.jtho.2020.01.002.
  • Liu M, Sun T, Li N, Peng J, Fu D, Li W, Li L, Gao W-Q. BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration. Nat Commun. 2019;10(1):4614. doi:10.1038/s41467-019-12573-z.
  • Ding Y, Li N, Dong B, Guo W, Wei H, Chen Q, Yuan H, Han Y, Chang H, Kan S, et al. Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer. J Clin Invest. 2019;129(2):759–73. doi:10.1172/JCI123557.
  • Sun L, Yuan Y, Chen J, Ma C, Xu Y. Brahma related gene 1 (BRG1) regulates breast cancer cell migration and invasion by activating MUC1 transcription. Biochem Bioph Res Co. 2019;511(3):536–43. doi:10.1016/j.bbrc.2019.02.088.
  • Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K, et al. The BRG1/SOX9 axis is critical for acinar cell–derived pancreatic tumorigenesis. J Clin Invest. 2018;128(8):3475–89. doi:10.1172/JCI94287.
  • Wang Y, Yang CH, Schultz AP, Sims MM, Miller DD, Pfeffer LM. Brahma-Related Gene-1 (BRG1) promotes the malignant phenotype of glioblastoma cells. J Cell Mol Med. 2021;25(6):2956–66. doi:10.1111/jcmm.16330.
  • Wang P, Song X, Cao D, Cui K, Wang J, Utpatel K, Shang R, Wang H, Che L, Evert M, et al. Oncogene-dependent function of BRG1 in hepatocarcinogenesis. Cell Death Dis. 2020;11(2):91. doi:10.1038/s41419-020-2289-3.
  • Kaufmann B, Wang B, Zhong S, Laschinger M, Patil P, Lu M, Assfalg V, Cheng Z, Friess H, Hüser N, et al. BRG1 promotes hepatocarcinogenesis by regulating proliferation and invasiveness. PLoS One. 2017;12(7):e0180225. doi:10.1371/journal.pone.0180225.
  • Bultman SJ, Holley DW, G GDR, Pizzo SV, Sidorova TN, Murray KT, Jensen BC, Wang Z, Bevilacqua A, Chen X, et al. BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo. Cardiovasc Pathol. 2016;25(3):258–69. doi:10.1016/j.carpath.2016.02.004.
  • Tang Z, Takahashi Y, Wang HG. ATG2 regulation of phagophore expansion at mitochondria-associated ER membranes. Autophagy. 2019;15(12):2165–66. doi:10.1080/15548627.2019.1666594.
  • Liu X, Li M, Chen Z, Yu Y, Shi H, Yu Y, Wang Y, Chen R, Ge J. Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis. Basic Res Cardiol. 2022;117(1):40. doi:10.1007/s00395-022-00948-1.
  • Komatsu S, Nomiyama T, Numata T, Kawanami T, Hamaguchi Y, Iwaya C, Horikawa T, Fujimura-Tanaka Y, Hamanoue N, Motonaga R, et al. SGLT2 inhibitor ipragliflozin attenuates breast cancer cell proliferation. Endocr J. 2020;67(1):99–106. doi:10.1507/endocrj.EJ19-0428.
  • Lee EG, Chen S, Leong L, Tulloch J, Yu CE. TOMM40 RNA transcription in alzheimer’s disease brain and its implication in mitochondrial dysfunction. Genes. 2021;12(6):871. doi:10.3390/genes12060871.
  • Zhu Z, Yang Y, Xiao Z, Zhao Q, Wu W, Liang X, Luo J, Cao Y, Shao M, Guo Q, et al. TOMM40 and APOE variants synergistically increase the risk of Alzheimer’s disease in a Chinese population. Aging Clin Exp Res. 2021;33(6):1667–75. doi:10.1007/s40520-020-01661-6.
  • Xu G, Li JY. ATP5A1 and ATP5B are highly expressed in glioblastoma tumor cells and endothelial cells of microvascular proliferation. J Neurooncol. 2016;126(3):405–13. doi:10.1007/s11060-015-1984-x.
  • Yuan L, Chen L, Qian K, Wang G, Lu M, Qian G, Cao X, Jiang W, Xiao Y, Wang X, et al. A novel correlation between ATP5A1 gene expression and progression of human clear cell renal cell carcinoma identified by co‑expression analysis. Oncol Rep. 2018;39(2):525–36. doi:10.3892/or.2017.6132.
  • Zhang G, Zhong J, Lin L, Liu Z. Loss of ATP5A1 enhances proliferation and predicts poor prognosis of colon adenocarcinoma. Pathol Res Pract. 2022;230:153679. doi:10.1016/j.prp.2021.153679.
  • Fukumoto T, Magno E, Zhang R. SWI/SNF complexes in ovarian cancer: Mechanistic Insights and therapeutic implications. Mol Cancer Res. 2018;16(12):1819–25. doi:10.1158/1541-7786.MCR-18-0368.
  • Mittal P, Roberts CWM. The SWI/SNF complex in cancer - biology, biomarkers and therapy. Nat Rev Clin Oncol. 2020;17(7):435–48. doi:10.1038/s41571-020-0357-3.
  • Xiao L, Parolia A, Qiao Y, Bawa P, Eyunni S, Mannan R, Carson SE, Chang Y, Wang X, Zhang Y, et al. Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer. Nature. 2022;601(7893):434–39. doi:10.1038/s41586-021-04246-z.
  • Wanior M, Krämer A, Knapp S, Joerger AC. Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy. Oncogene. 2021;40(21):3637–54. doi:10.1038/s41388-021-01781-x.
  • Li Z, Xia J, Fang M, Xu Y. Epigenetic regulation of lung cancer cell proliferation and migration by the chromatin remodeling protein BRG1. Oncogenesis. 2019;8(11):66. doi:10.1038/s41389-019-0174-7.
  • Shao J, Xu Y, Fang M. BRG1 deficiency in endothelial cells alleviates thioacetamide induced liver fibrosis in mice. Biochem Bioph Res Co. 2020;521(1):212–19. doi:10.1016/j.bbrc.2019.10.109.
  • Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria in cancer cells: what is so special about them? Trends in cell biology. Trends Cell Biol. 2008;18(4):165–73. doi:10.1016/j.tcb.2008.01.006.
  • Lim SY, Davidson SM, Hausenloy DJ, Yellon DM. Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore. Cardiovasc Res. 2007;75(3):530–35. doi:10.1016/j.cardiores.2007.04.022.
  • Armstrong J. The role of the mitochondrial permeability transition in cell death. Mitochondrion. 2006;6(5):225–34. doi:10.1016/j.mito.2006.07.006.