References
- Longo VD, Mattson MP. Fasting: molecular mechanisms and clinical applications. Cell Metab [Internet]. 2014;19:181–192. Available from.
- Seyer P, Vallois D, Poitry-Yamate C, et al. Hepatic glucose sensing is required to preserve β cell glucose competence. J Clin Invest [Internet]. 2013;123:1662–1676. cited 2015 Apr 14. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3613916&tool=pmcentrez&rendertype=abstract
- Sengupta S, Peterson TR, Laplante M, et al. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature [Internet]. 2010;468:1100–1104. Available from.
- Tan VP, Miyamoto S. Nutrient-sensing mTORC1: integration of metabolic and autophagic signals. J Mol Cell Cardiol [Internet]. 2016:1–11. Available from http://www.sciencedirect.com/science/article/pii/S0022282816300025
- Xiao B, Sanders MJ, Underwood E, et al. Structure of mammalian AMPK and its regulation by ADP. Nature [Internet]. 2011;472:230–233. Available from.
- Lage R, Diéguez C, Vidal-Puig A, et al. AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med. 2008;14:539–549.
- Gwinn DM, Shackelford DB, Egan DF, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell [Internet]. 2008;30:214–226. Available from http://linkinghub.elsevier.com/retrieve/pii/S109727650800169X
- Finck BN, Kelly DP. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest. 2006;116:615–622.
- Potthoff MJ, Finck BN. Head over hepatocytes for FGF21. Diabetes. 2014;63:4013–4015.
- Martina JA, Chen Y, Gucek M, et al. MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy. 2012;8:903–914.
- Settembre C, De Cegli R, Mansueto G, et al. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol [Internet]. 2013;15:647–658. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23604321
- Holmes D. Metabolism: fasting induces FGF21 in humans. Nat Rev Endocrinol [Internet]. 2016;12:3. Available from.
- Xu J, Lloyd DJ, Hale C, et al. FGF21 reverses hepatic steatosis, increases energy expenditure and improves insulin sensitivity in diet-induced obese mice. Diabetes [Internet]. 2009;58:250–259. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18840786
- Kim KH, Lee MS. FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs. J Endocrinol. 2015;226:R1–16.
- Potthoff MJ, Inagaki T, Satapati S, et al. FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A [Internet]. 2009;106:10853–10858. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19541642
- Gaich G, Chien JY, Fu H, et al. The effects of LY2405319, an FGF21 Analog, in obese human subjects with type 2 diabetes. Cell Metab [Internet]. 2013;18:333–340. Available from.
- Li Y, Wong K, Giles A, et al. Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology. 2014;146:539–549.
- Villarroya F, Cereijo RR, Villarroya J, et al. Brown adipose tissue as a secretory organ. Nat Rev Endocrinol [Internet]. 2017;13:26–35. Available from.
- Mardones P, Rubinsztein DC, Hetz C. Mystery solved: trehalose kickstarts autophagy by blocking glucose transport. Sci Signal [Internet]. 2016;9:fs2LP–fs2. Available from http://stke.sciencemag.org/content/9/416/fs2.abstract
- DeBosch BJ, Heitmeier MR, Mayer AL, et al. Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal [Internet]. 2016;9:ra21–ra21. Available from: http://stke.sciencemag.org/content/9/416/ra21.abstract
- DeBosch BJ, Chen Z, Finck BN, et al. Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice. Mol Endocrinol [Internet]. 2013;27:1887–1896. DOI: 10.1210/me.2013-1137
- Castillo K, Nassif M, Valenzuela V, et al. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Autophagy. 2013;9:1308–1320.
- Aguib Y, Heiseke A, Gilch S, et al. Autophagy induction by trehalose counteracts cellular prion infection. Autophagy. 2009;5:361–369.
- Sarkar S, Davies JE, Huang Z, et al. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and α-synuclein. J Biol Chem [Internet]. 2007;282:5641–5652. cited 2014 Oct 6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17182613
- Mayer AL, Higgins CB, Heitmeier MR, et al. SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy. Sci Rep [Internet]. 2016;6:38586. Available from.
- Menzies FM, Fleming A, Caricasole A, et al. Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities. Neuron [Internet]. 2017;93:1015–1034. Available from.
- Sergin I, Evans TD, Zhang X, et al. Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis. Nat Commun [Internet]. 2017;8:15750. DOI: 10.1038/ncomms15750
- Arai C, Arai N, Mizote A, et al. Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance. Nutr Res. 2010;30:840–848.
- Cornu M, Oppliger W, Albert V, et al. Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21. Proc Natl Acad Sci U S A [Internet]. 2014;111:11592–11599. Available from http://stke.sciencemag.org/content/vj/pnas/111/32/11592.full
- Jo YH, Buettner C. Why leptin keeps you warm. Mol Metab [Internet]. 2014;3:779–780. Available from.
- Richards AB, Krakowka S, Dexter LB, et al. Trehalose: A review of properties, history of use and human tolerance, and results of multiple safety studies. Food Chem Toxicol. 2002;40:871–898.
- Krüger U, Wang Y, Kumar S, et al. Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiol Aging [Internet]. 2016;33:2291–2305. Available from.
- Zhang X, Chen S, Song L, et al. MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis. Autophagy. 2014;10:588–602.
- Salem M, Ammitzboell M, Nys K, et al. ATG16L1: A multifunctional susceptibility factor in crohn disease. Autophagy. 2015;11:585–594.
- Kang R, Zeh HJ, Lotze MT, et al. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ [Internet]. 2011;18:571–580. Available from.
- Cadwell K, Liu JY, Brown SL, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature [Internet]. 2008;456:259–263. Available from.
- Wang C, Symington JW, Mysorekar IU. ATG16L1 and pathogenesis of urinary tract infections. Autophagy. 2012;8:1693–1694.
- Piano Mortari E, Folgiero V, Marcellini V, et al. The Vici syndrome protein EPG5 regulates intracellular nucleic acid trafficking linking autophagy to innate and adaptive immunity. Autophagy. 2017;1–16. DOI:10.1080/15548627.2017.1389356
- Zhao H, Zhao YG, Wang X, et al. Mice deficient in epg5 exhibit selective neuronal vulnerability to degeneration. J Cell Biol. 2013;200:731–741.
- Zhao YG, Zhao H, Sun H, et al. Role of Epg5 in selective neurodegeneration and Vici syndrome. Autophagy. 2013;9:1258–1262.
- Wang Z, Miao G, Xue X, et al. The vici syndrome protein EPG5 Is a Rab7 effector that determines the fusion specificity of autophagosomes with late endosomes/lysosomes. Mol Cell [Internet]. 2016;63:781–795. Available from.
- Divakaruni AS, Paradyse A, Ferrick DA, et al. Analysis and interpretation of microplate-based oxygen consumption and pH data. 1st ed. Amsterdam: Elsevier Inc. 2014. DOI:10.1016/B978-0-12-801415-8.00016-3
- Potthoff MJ, Kliewer SA, Mangelsdorf DJ. Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes Dev. 2012;26:312–324.
- Kim KH, Jeong YT, Oh H, et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med [Internet]. 2013;19:83–92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23202295
- Markan KR, Naber MC, Ameka MK, et al. Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding. Diabetes. 2014;63:4057–4063.
- Settembre C, Ballabio A. Lysosome: regulator of lipid degradation pathways. Trends Cell Biol [Internet]. 2014;24:743–750. Available from.
- Siddiqui A, Bhaumik D, Chinta SJ, et al. Mitochondrial quality control via the PGC1α-TFEB signaling pathway is compromised by parkin Q311X mutation but independently restored by Rapamycin. J Neurosci [Internet]. 2015;35:12833–12844. Available from http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.0109-15.2015
- Puigserver P. Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-α. Int J Obes [Internet]. 2005;29:S5–9. DOI: 10.1038/sj.ijo.0802905
- Ishigaki Y, Katagiri H, Yamada T, et al. Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity. Diabetes. 2005;54:322–332.
- Stoner HB. The role of the liver in non-shivering thermogenesis in the rat. J Physiol [Internet]. 1973;232:285–296. Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1350455/
- Adachi A, Fwnahashi M, Ohga J. Hepatic Thermoogenesis relation to food intake in the conscious rat. Brain Res Bull. 1991;27:529–533.
- Settembre C, Zoncu R, Medina DL, et al. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB open. EMBO J [Internet]. 2012;31:1095–1108. Available from.
- Hondares E, Rosell M, Gonzalez FJ, et al. Hepatic FGF21 expression is induced at birth via PPAR?? in response to milk intake and contributes to thermogenic activation of Neonatal Brown Fat. Cell Metab [Internet]. 2010;11:206–212.
- Fisher M, Kleiner S, Douris N, et al. adaptive thermogenesis FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis. Genes Dev [Internet]. 2012;26:271–281. Available from: http://www.luminpdf.com/files/5951223/Fisher_FM_2012.pdf
- Fu T, Seok S, Choi S, et al. MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function. Mol Cell Biol [Internet]. 2014;34:4130–4142. Available from DOI:10.1128/MCB.00596-14
- Potthoff MJ. FGF21 and metabolic disease in 2016: A new frontier in FGF21 biology. Nat Rev Endocrinol [Internet]. 2016;13:74–76. DOI:10.1038/nrendo.2016.206
- Cyphert HA, Ge X, Kohan AB, et al. Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21. J Biol Chem. 2012;287:25123–25138.
- Domouzoglou EM, Maratos-Flier E. Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis. Am J Clin Nutr. 2011;93:901–905.
- Nedergaard J, Golozoubova V, Matthias A, et al. UCP1 : the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency. Biochim Biophys Acta. 2001;1504:82–106.
- Estall JL, Ruas JL, Soo C, et al. PGC-1a negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erba axis. Proc Natl Acad Sci U S A [Internet]. 2009:106:22510-22515.
- Chau MDL, Gao J, Yang Q, et al. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway. Proc Natl Acad Sci U S A [Internet]. 2010;107:12553–12558. Available from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2906565&tool=pmcentrez&rendertype=abstract
- Berglund ED, Kang L, Lee-Young RS, et al. Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivo. Am J Physiol Endocrinol Metab. 2010;299:E607–14.
- Kang HC, Chung DE, Kim DW, et al. Early- and late-onset complications of the ketogenic diet for intractable epilepsy. Epilepsia. 2004;45:1116–1123.
- Damms-Machado A, Weser G, Bischoff SC. Micronutrient deficiency in obese subjects undergoing low calorie diet. Nutr J [Internet]. 2012;11:34. DOI: 10.1186/1475-2891-11-34
- Martin B, Mattson MP, Maudsley S. Caloric restriction and intermittent fasting: two potential diets for successful brain aging. Ageing Res Rev. 2006;5:332–353.
- Stunkard AJ, Rush J. Dieting and depression reexamined. A critical review of reports of untoward responses during weight reduction for obesity. Ann Intern Med. 1974;81:526–533.
- Wl B, Gj A. Similarities of carbohydrate deficiency and fasting: I. weight loss, electrolyte excretion, and fatigue. Arch Intern Med [Internet]. 1963;112:333–337. Available from.
- Soufi N, Hall AM, Chen Z, et al. Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice. J Biol Chem. 2014;289:30177–30188.
- Mayer AL, Zhang Y, Feng EH, et al. Enhanced hepatic PPAR a activity links GLUT8 deficiency to augmented peripheral fasting responses in male mice. Endocrinology 2018;159:2110–2126.
- DeBosch BJ, Chen Z, Saben JL, et al. Glucose transporter 8 (GLUT8) mediates fructose-induced de Novo lipogenesis and macrosteatosis. J Biol Chem [Internet]. 2014;289:10989–10998. cited 2014 Aug 12. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4036240&tool=pmcentrez&rendertype=abstract
- DeBosch BJ, Kluth O, Fujiwara H, et al. Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat Commun. 2014;5:1–7.
- Trausch-Azar J, Leone TC, Kelly DP, et al. Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1?? via the N-terminal pathway. J Biol Chem. 2010;285:40192–40200.
- Leone TC, Lehman JJ, Finck BN, et al. PGC-1a deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 2005;3: 0672–87.