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Research Paper - Basic Science

AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells

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Pages 565-582 | Received 17 Oct 2017, Accepted 26 Sep 2018, Published online: 20 Oct 2018

References

  • Waalkes MP. Cadmium carcinogenesis. Mutat Res. 2003 Dec 10;533(1–2):107–120.
  • Satarug S, Baker JR, Urbenjapol S, et al. A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol Lett. 2003 Jan 31;137(1–2):65–83.
  • Perlman GD, Berman L, Leann K, et al. Agency for Toxic substances and disease registry brownfields/land-reuse site tool. J Environ Health. 2012 Dec;75(5):30–34.
  • Huang J, Okuka M, McLean M, et al. Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro. Free Radic Biol Med. 2010 Jun 15;48(12):1663–1676.
  • Larson C. ENVIRONMENTAL SCIENCE China gets serious about its pollutant-laden soil. Science. 2014 Mar 28;343(6178):1415–1416.
  • Jin L, Liu J, Ye B, et al. Concentrations of selected heavy metals in maternal blood and associated factors in rural areas in Shanxi Province, China. Environ Int. 2014;66:157–164.
  • Chen X, Ren S, Zhu G, et al. Emodin suppresses cadmium-induced osteoporosis by inhibiting osteoclast formation. Environ Toxicol Pharmacol. 2017;54:162–168.
  • Chen X, Wang K, Wang Z, et al. Effects of lead and cadmium co-exposure on bone mineral density in a Chinese population. Bone. 2014;63:76–80.
  • Yang M, Pi H, Li M, et al. From the cover: autophagy induction contributes to cadmium toxicity in mesenchymal stem cells via AMPK/FOXO3a/BECN1 signaling. Toxicol Sci. 2016 Nov;154(1):101–114.
  • Perera RM, Stoykova S, Nicolay BN, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015 Aug 20;524(7565):361–365.
  • Raben N, Puertollano R. TFEB and TFE3: linking Lysosomes to Cellular Adaptation to Stress. Annu Rev Cell Dev Biol. 2016 Oct 06;32:255–278.
  • Martina JA, Puertollano R. TFEB and TFE3: the art of multi-tasking under stress conditions. Transcription. 2017 Jan;8(1):48–54.
  • Pastore N, Brady OA, Diab HI, et al. TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Autophagy. 2016;12(8):1240–1258.
  • Bordi M, Berg MJ, Mohan PS, et al. Autophagy flux in CA1 neurons of Alzheimer hippocampus: increased induction overburdens failing lysosomes to propel neuritic dystrophy. Autophagy. 2016;Dec;12(12):2467–2483.
  • Martina JA, Diab HI, Brady OA, et al. TFEB and TFE3 are novel components of the integrated stress response. Embo Journal. 2016 Mar 1;35(5):479–495.
  • Martina JA, Diab HI, Lishu L, et al. The nutrient-responsive transcription factor tfe3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris. Sci Signal. 2014 Jan 21;7:309.
  • Slade L, Pulinilkunnil T. The MiTF/TFE family of transcription factors: master regulators of organelle signaling, metabolism and stress adaptation. Mol Cancer Res. 2017 Aug 29.
  • Roczniak-Ferguson A, Petit CS, Froehlich F, et al. The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci Signal. 2012 Jun 12;5(228):ra42.
  • Kliosnky D. Guidelines for the Use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(2):443.
  • Pi H, Xu S, Reiter RJ, et al. SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy. 2015;11(7):1037–1051.
  • Ferguson SM. Beyond indigestion: emerging roles for lysosome-based signaling in human disease. Curr Opin Cell Biol. 2015 Aug;35:59–68.
  • Zhou J, Tan SH, Nicolas V, et al. Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res. 2013 Apr;23(4):508–523.
  • Fan T, Pi H, Li M, et al. Inhibiting MT2-TFE3-dependent autophagy enhances melatonin-induced apoptosis in tongue squamous cell carcinoma. J Pineal Res. 2017 Nov;17.
  • Palmieri M, Pal R, Nelvagal HR, et al. mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. Nat Commun. 2017 Feb 06;8:14338.
  • Larison JR, Likens GE, Fitzpatrick JW, et al. Cadmium toxicity among wildlife in the colorado rocky mountains. Nature. 2000 Jul 13;406(6792):181–183.
  • Abnosi MH, Golami S. Cadmium chloride treatment of rats significantly impairs membrane integrity of mesenchymal stem cells via electrolyte imbalance and lipid peroxidation, a possible explanation of Cd related osteoporosis. Iran J Basic Med Sci. 2017 Mar;20(3):280–287.
  • Sarwar N, Malhi SS, Zia MH, et al. Role of mineral nutrition in minimizing cadmium accumulation by plants. J Sci Food Agric. 2010 Apr 30;90(6):925–937.
  • Abu-Hayyeh S, Sian M, Jones KG, et al. Cadmium accumulation in aortas of smokers. Arterioscler Thromb Vasc Biol. 2001 May;21(5):863–867.
  • Akesson A, Bjellerup P, Lundh T, et al. Cadmium-induced effects on bone in a population-based study of women. Environ Health Perspect. 2006 Jun;114(6):830–834.
  • Sughis M, Penders J, Haufroid V, et al. Bone resorption and environmental exposure to cadmium in children: a cross–sectional study. Environ Health. 2011 Dec;8(10):104.
  • Schutte R, Nawrot TS, Richart T, et al. Bone resorption and environmental exposure to cadmium in women: a population study. Environ Health Perspect. 2008 Jun;116(6):777–783.
  • Chen X, Zhu G, Gu S, et al. Effects of cadmium on osteoblasts and osteoclasts in vitro. Environ Toxicol Pharmacol. 2009 Sep;28(2):232–236.
  • Arbon KS, Christensen CM, Harvey WA, et al. Cadmium exposure activates the ERK signaling pathway leading to altered osteoblast gene expression and apoptotic death in Saos-2 cells. Food Chem Toxicol. 2012 Feb;50(2):198–205.
  • Rodriguez J, Mandalunis PM. Effect of cadmium on bone tissue in growing animals. Exp Toxicol Pathol. 2016 Aug;68(7):391–397.
  • Chen X, Qin B, Li X, et al. Effects of fluoride and cadmium co-exposure on bone in male rats. Biol Trace Elem Res. 2013 Sep;154(3):396–402.
  • Hussein AM, Hasan S. Cadmium affects viability of bone marrow mesenchymal stem cells through membrane impairment, intracellular calcium elevation and DNA breakage. Indian J Med Sci. 2010 Apr;64(4):177–186.
  • Liu Y, Levine B. Autosis and autophagic cell death: the dark side of autophagy. Cell Death Differ. 2014 Sep 26. DOI:10.1038/cdd.2014.143.
  • Rehli M, Lichanska A, Cassady AI, et al. TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors. J Immunol. 1999 Feb 01;162(3):1559–1565.
  • Ploper D, De Robertis EM. The MITF family of transcription factors: role in endolysosomal biogenesis, Wnt signaling, and oncogenesis. Pharmacol Res. 2015 Sep;99:36–43.
  • Martina JA, Diab HI, Li H, et al. Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis. Cell Mol Life Sci. 2014 Jul;71(13):2483–2497.
  • Ouyang ZH, Wang WJ, Yan YG, et al. The PI3K/Akt pathway: a critical player in intervertebral disc degeneration. Oncotarget. 2017 Aug 22;8(34):57870–57881.
  • Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev. 1999 Nov 15;13(22):2905–2927.
  • Wang RC, Wei Y, An Z, et al. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science. 2012 Nov 16;338(6109):956–959.
  • Arias E, Koga H, Diaz A, et al. Lysosomal mTORC2/PHLPP1/Akt regulate chaperone-mediated autophagy. Mol Cell. 2015 Jul 16;59(2):270–284.
  • Nezich CL, Wang CX, Fogel AI, et al. MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. J Cell Biol. 2015 Aug 3;210(3):435–450.
  • Taniguchi M, Nadanaka S, Tanakura S, et al. TFE3 Is a bHLH-ZIP-type transcription factor that regulates the mammalian golgi stress response. Cell Struct Funct. 2015;40(1):13–30.
  • Steiner JP, Dawson TM, Fotuhi M, et al. High brain densities of the immunophilin FKBP colocalized with calcineurin. Nature. 1992 Aug 13;358(6387):584–587.
  • Park CH, Kim YS, Kim YH, et al. Calcineurin mediates AKT dephosphorylation in the ischemic rat retina. Brain Res. 2008 Oct;09(1234):148–157.
  • Gabryel B, Pudelko A, Adamczyk J, et al. Calcineurin and Erk1/2-signaling pathways are involved in the antiapoptotic effect of cyclosporin A on astrocytes exposed to simulated ischemia in vitro. Naunyn Schmiedebergs Arch Pharmacol. 2006 Nov;374(2):127–139.
  • Medina DL, Di Paola S, Peluso I, et al. Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat Cell Biol. 2015 Mar;17(3):288–299.
  • Song R, Li J, Zhang J, et al. Peptides derived from transcription factor EB bind to calcineurin at a similar region as the NFAT-type motif. Biochimie. 2017;142:158–167.
  • Wang SH, Shih YL, Kuo TC, et al. Cadmium toxicity toward autophagy through ros-activated gsk-3 beta in mesangial cells. Toxicol Sci. 2009 Mar;108(1):124–131.
  • Pi H, Xu S, Zhang L, et al. Dynamin 1-like-dependent mitochondrial fission initiates overactive mitophagy in the hepatotoxicity of cadmium. Autophagy. 2013 Nov 01;9(11):1780–1800.
  • Pi H, Li M, Tian L, et al. Enhancing lysosomal biogenesis and autophagic flux by activating the transcription factor EB protects against cadmium-induced neurotoxicity. Sci Rep. 2017 Feb;27(7):43466.
  • Li M, Pi HF, Yang ZQ, et al. Melatonin antagonizes cadmium-induced neurotoxicity by activating the transcription factor EB-dependent autophagy-lysosome machinery in mouse neuroblastoma cells. J Pineal Res. 2016 Oct;61(3):353–369.
  • Li L, Li M, Yu L, et al. The FLS2-associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity. Cell Host & Microbe. 2014 Mar 12;15(3):329–338.
  • Zhu G, Fan Z, Ding M, et al. An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis. Oncogene. 2015 Dec 3;34(49):5971–5982.
  • Uhlen M, Bandrowski A, Carr S, et al. A proposal for validation of antibodies. Nature Methods. 2016 Oct;13(10):823–827.
  • Yin JA, Gao G, Liu XJ, et al. Genetic variation in glia-neuron signalling modulates ageing rate. Nature. 2017 Nov 8;551(7679):198–203.
  • Guo P, Pi H, Xu S, et al. Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro. Toxicol Sci. 2014 Nov;142(1):182–195.
  • Li Y, Xu M, Ding X, et al. Protein kinase C controls lysosome biogenesis independently of mTORC1. Nat Cell Biol. 2016 Oct;18(10):1065–1077.
  • Faccenda D, Tan CH, Seraphim A, et al. IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling. Cell Death Differ. 2013 May;20(5):686–697.
  • Niitsu H, Hinoi T, Kawaguchi Y, et al. KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer. Oncogenesis. 2016 Aug 15;5(8):e253.

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