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Research Paper - Basic Science

Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells

, , , , , , , , , , , , , , , , , , & ORCID Icon show all
Pages 707-725 | Received 21 Aug 2017, Accepted 05 Dec 2018, Published online: 06 Jan 2019

References

  • Fukase K, Kato M, Kikuchi S, et al. Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial. Lancet. 2008 Aug 2;372(9636):392–397. PubMed PMID: 18675689.
  • Thung I, Aramin H, Vavinskaya V, et al. Review article: the global emergence of Helicobacter pylori antibiotic resistance. Aliment Pharmacol Ther. 2016 Feb;43(4):514–533. PubMed PMID: 26694080; PubMed Central PMCID: PMCPMC5064663.
  • Allen LA, Schlesinger LS, Kang B. Virulent strains of Helicobacter pylori demonstrate delayed phagocytosis and stimulate homotypic phagosome fusion in macrophages. J Exp Med. 2000 Jan 3;191(1):115–128. PubMed PMID: 10620610; PubMed Central PMCID: PMCPMC2195807.
  • Deen NS, Huang SJ, Gong L, et al. The impact of autophagic processes on the intracellular fate of Helicobacter pylori: more tricks from an enigmatic pathogen? Autophagy. 2013 May;9(5):639–652. PubMed PMID: 23396129; PubMed Central PMCID: PMCPMC3669176.
  • Chu YT, Wang YH, Wu JJ, et al. Invasion and multiplication of Helicobacter pylori in gastric epithelial cells and implications for antibiotic resistance. Infect Immun. 2010 Oct;78(10):4157–4165. PubMed PMID: 20696835; PubMed Central PMCID: PMCPMC2950335.
  • Wang YH, Gorvel JP, Chu YT, et al. Helicobacter pylori impairs murine dendritic cell responses to infection. PLoS One. 2010 May 27;5(5):e10844. PubMed PMID: 20523725; PubMed Central PMCID: PMCPMC2877707.
  • Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1–222. PubMed PMID: 26799652; PubMed Central PMCID: PMCPMC4835977.
  • He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet. 2009;43:67–93. PubMed PMID: 19653858; PubMed Central PMCID: PMCPMC2831538.
  • Rich KA, Burkett C, Webster P. Cytoplasmic bacteria can be targets for autophagy. Cell Microbiol. 2003 Jul;5(7):455–468. PubMed PMID: 12814436.
  • Levine B. Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell. 2005 Jan 28;120(2):159–162. PubMed PMID: 15680321.
  • Terebiznik MR, Raju D, Vazquez CL, et al. Effect of Helicobacter pylori’s vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells. Autophagy. 2009 Apr;5(3):370–379. PubMed PMID: 19164948.
  • Raju D, Hussey S, Ang M, et al. Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology. 2012 May;142(5):1160–1171. PubMed PMID: 22333951; PubMed Central PMCID: PMCPMC3336037.
  • Campbell GR, Spector SA. Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy. PLoS Pathog. 2012;85:e1002689. PubMed PMID: 22589721; PubMed Central PMCID: PMCPMC3349755.
  • Lee A, O’Rourke J, De Ungria MC, et al. A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterology. 1997 Apr;112(4):1386–1397. PubMed PMID: 9098027.
  • Zhang L, Hu W, Cho CH, et al. Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori. J Pathol. 2018 Apr;244(4):432–444. PubMed PMID: 29327342.
  • Yuk JM, Shin DM, Lee HM, et al. Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe. 2009 Sep 17;6(3):231–243. PubMed PMID: 19748465.
  • Zhang L, Yu J, Wong CC, et al. Cathelicidin protects against Helicobacter pylori colonization and the associated gastritis in mice. Gene Ther. 2013 Jul;20(7):751–760. PubMed PMID: 23254369.
  • Zhang L, Wu WK, Gallo RL, et al. Critical role of antimicrobial peptide cathelicidin for controlling helicobacter pylori survival and infection. J Immunol. 2016 Feb 15;196(4):1799–1809. PubMed PMID: 26800870.
  • Yoshii SR, Mizushima N. Monitoring and measuring autophagy. Int J Mol Sci. 2017 Aug 28;18(9):1865. PubMed PMID: 28846632; PubMed Central PMCID: PMCPMC5618514.
  • Stoka V, Turk V, Turk B. Lysosomal cathepsins and their regulation in aging and neurodegeneration. Ageing Res Rev. 2016 Dec;32:22–37. PubMed PMID: 27125852.
  • Kaji T, Ishihara S, Ashizawa N, et al. Adherence of Helicobacter pylori to gastric epithelial cells and mucosal inflammation. J Lab Clin Med. 2002 Apr;139(4):244–250. PubMed PMID: 12024112.
  • Ozbek A, Ozbek E, Dursun H, et al. Can Helicobacter pylori invade human gastric mucosa?: an in vivo study using electron microscopy, immunohistochemical methods, and real-time polymerase chain reaction. J Clin Gastroenterol. 2010 Jul;44(6):416–422. PubMed PMID: 19904218.
  • Liu Y, Hidaka E, Kaneko Y, et al. Ultrastructure of Helicobacter pylori in human gastric mucosa and H. pylori-infected human gastric mucosa using transmission electron microscopy and the high-pressure freezing-freeze substitution technique. J Gastroenterol. 2006 Jun;41(6):569–574. PubMed PMID: 16868805.
  • Mindell JA. Lysosomal acidification mechanisms. Annu Rev Physiol. 2012;74:69–86. PubMed PMID: 22335796.
  • Hundeshagen P, Hamacher-Brady A, Eils R, et al. Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy. BMC Biol. 2011 Jun 2;9:38. PubMed PMID: 21635740; PubMed Central PMCID: PMCPMC3121655.
  • Wolfe DM, Lee JH, Kumar A, et al. Autophagy failure in Alzheimer’s disease and the role of defective lysosomal acidification. Eur J Neurosci. 2013 Jun;37(12):1949–1961. PubMed PMID: 23773064; PubMed Central PMCID: PMCPMC3694736.
  • Huss M, Ingenhorst G, Konig S, et al. Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c. J Biol Chem. 2002 Oct 25;277(43):40544–40548. PubMed PMID: 12186879.
  • Gerasimenko JV, Tepikin AV, Petersen OH, et al. Calcium uptake via endocytosis with rapid release from acidifying endosomes. Curr Biol. 1998 Dec 3;8(24):1335–1338. PubMed PMID: 9843688.
  • Lloyd-Evans E, Morgan AJ, He X, et al. Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat Med. 2008 Nov;14(11):1247–1255. PubMed PMID: 18953351.
  • Zeevi DA, Frumkin A, Bach G. TRPML and lysosomal function. Biochim Biophys Acta. 2007 Aug;1772(8):851–858. PubMed PMID: 17306511.
  • Di Palma F, Belyantseva IA, Kim HJ, et al. Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14994–14999. PubMed PMID: 12403827; PubMed Central PMCID: PMCPMC137533.
  • Medina DL, Ballabio A. Lysosomal calcium regulates autophagy. Autophagy. 2015;116:970–971. PubMed PMID: 26000950; PubMed Central PMCID: PMCPMC4502748.
  • Pike JW. Vitamin D3 receptors: structure and function in transcription. Annu Rev Nutr. 1991;11:189–216. PubMed PMID: 1654066.
  • Chen J, Olivares-Navarrete R, Wang Y, et al. Protein-disulfide isomerase-associated 3 (Pdia3) mediates the membrane response to 1,25-dihydroxyvitamin D3 in osteoblasts. J Biol Chem. 2010 Nov 19;285(47):37041–37050. PubMed PMID: 20843786; PubMed Central PMCID: PMCPMC2978632.
  • Nemere I, Garbi N, Hammerling GJ, et al. Intestinal cell calcium uptake and the targeted knockout of the 1,25D3-MARRS (membrane-associated, rapid response steroid-binding) receptor/PDIA3/Erp57. J Biol Chem. 2010 Oct 8;285(41):31859–31866. PubMed PMID: 20682787; PubMed Central PMCID: PMCPMC2951257.
  • Levy DE, Lee CK. What does Stat3 do? J Clin Invest. 2002 May;109(9):1143–1148. PubMed PMID: 11994402; PubMed Central PMCID: PMCPMC150972.
  • Biancuzzo RM, Clarke N, Reitz RE, et al. Serum concentrations of 1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 in response to vitamin D2 and vitamin D3 supplementation. J Clin Endocrinol Metab. 2013 Mar;98(3):973–979. PubMed PMID: 23386645; PubMed Central PMCID: PMCPMC3590486.
  • Nishizawa T, Suzuki H. Mechanisms of Helicobacter pylori antibiotic resistance and molecular testing. Front Mol Biosci. 2014;1:19. PubMed PMID: 25988160; PubMed Central PMCID: PMCPMC4428472.
  • Tsugawa H, Suzuki H, Saya H, et al. Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells. Cell Host Microbe. 2012 Dec 13;12(6):764–777. PubMed PMID: 23245321.
  • Lelouvier B, Puertollano R. Mucolipin-3 regulates luminal calcium, acidification, and membrane fusion in the endosomal pathway. J Biol Chem. 2011 Mar 18;286(11):9826–9832. PubMed PMID: 21245134; PubMed Central PMCID: PMCPMC3058973.
  • Hewison M. Antibacterial effects of vitamin D. Nat Rev Endocrinol. 2011 Jun;7(6):337–345. PubMed PMID: 21263449.
  • Wei R, Christakos S. Mechanisms underlying the regulation of innate and adaptive immunity by vitamin d. Nutrients. 2015 Sep 24;7(10):8251–8260. PubMed PMID: 26404359; PubMed Central PMCID: PMCPMC4632412.
  • Youssef DA, Miller CW, El-Abbassi AM, et al. Antimicrobial implications of vitamin D. Dermatoendocrinol. 2011 Oct;3(4):220–229. PubMed PMID: 22259647; PubMed Central PMCID: PMCPMC3256336.
  • Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J. 2005 Jul;19(9):1067–1077. PubMed PMID: 15985530.
  • Li M, Li L, Zhang L, et al. 1,25-Dihydroxyvitamin D3 suppresses gastric cancer cell growth through VDR- and mutant p53-mediated induction of p21. Life Sci. 2017 Jun 15;179:88–97. PubMed PMID: 28465245.
  • Cantorna MT. Mechanisms underlying the effect of vitamin D on the immune system. Proc Nutr Soc. 2010 Aug;69(3):286–289. PubMed PMID: 20515520; PubMed Central PMCID: PMCPMC3138329.
  • Chun RF, Liu PT, Modlin RL, et al. Impact of vitamin D on immune function: lessons learned from genome-wide analysis. Front Physiol. 2014;5:151. PubMed PMID: 24795646; PubMed Central PMCID: PMCPMC4000998.
  • Turano C, Gaucci E, Grillo C, et al. ERp57/GRP58: a protein with multiple functions. Cell Mol Biol Lett. 2011 Dec;16(4):539–563. PubMed PMID: 21837552.
  • Tohda C, Urano T, Umezaki M, et al. Diosgenin is an exogenous activator of 1,25D(3)-MARRS/Pdia3/ERp57 and improves Alzheimer’s disease pathologies in 5XFAD mice. Sci Rep. 2012;2:535. PubMed PMID: 22837815; PubMed Central PMCID: PMCPMC3405293.
  • Xu H, Ren D. Lysosomal physiology. Annu Rev Physiol. 2015;77:57–80. PubMed PMID: 25668017; PubMed Central PMCID: PMCPMC4524569.
  • He J, Shi W, Guo Y, et al. ERp57 modulates mitochondrial calcium uptake through the MCU. FEBS Lett. 2014 Jun 5;588(12):2087–2094. PubMed PMID: 24815697.
  • Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:138–145. PubMed PMID: 24239505; PubMed Central PMCID: PMCPMC4018438.
  • Leung FP, Yao X, Lau CW, et al. Raloxifene relaxes rat intrarenal arteries by inhibiting Ca2+ influx. Am J Physiol Renal Physiol. 2005 Jul;289(1):F137–44. PubMed PMID: 15713909.
  • Hu W, Chen SS, Zhang JL, et al. Dihydroartemisinin induces autophagy by suppressing NF-kappaB activation. Cancer Lett. 2014 Feb 28;343(2):239–248. PubMed PMID: 24099910.