Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation

References

• Lanier LL. 2005. Nk cell recognition. AnnuRevImmunol. 23:225–274.
   Web of Science ®Google Scholar
• Manilay JO, Sykes M. 1998. Natural killer cells and their role in graft rejection. Curr Opin Immunol. 10(5):532–538.
   PubMed Web of Science ®Google Scholar
• Herberman RB, Nunn ME, Holden HT, Lavrin DH. 1975. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. li. Characterization of effector cells. IntJCancer. 16(2):230–239.
   Google Scholar
• Kiessling R, Petranyi G, Klein G, Wigzel H. 1975. Genetic variation of in vitro cytolytic activity and in vivo rejection potential of non-immunized semi-syngeneic mice against a mouse lymphoma line. IntJCancer. 15(6):933–940.
   Google Scholar
• Ljunggren HG, Karre K. 1990. In search of the ‘missing self’: mhc molecules and nk cell recognition. ImmunolToday. 11(7):237–244.
   Web of Science ®Google Scholar
• Velardi A, Ruggeri L, Mancusi A, Aversa F, Christiansen FT. 2009. Natural killer cell allorecognition of missing self in allogeneic hematopoietic transplantation: A tool for immunotherapy of leukemia. CurrOpinImmunol. 21(5):525–530.
   Google Scholar
• Yokoyama WM, Daniels BF, Seaman WE, Hunziker R, Margulies DH, Smith HR. 1995. A family of murine nk cell receptors specific for target cell mhc class i molecules. Semin Immunol. 7(2):89–101. doi:10.1006/smim.1995.0013.
   PubMedGoogle Scholar
• Snell GD, Jackson RB. 1958. Histocompatibility genes of the mouse. Ii. Production and analysis of isogenic resistant lines. J Natl Cancer Inst. 21(5):843–877.
   PubMedGoogle Scholar
• Cudkowicz G, Bennett M. 1971. Peculiar immunobiology of bone marrow allografts. Ii. Rejection of parental grafts by resistant f 1 hybrid mice. JExpMed. 134(6):1513–1528. doi:10.1084/jem.134.6.1513.
   Google Scholar
• Suzue K, Reinherz EL, Koyasu S. 2001. Critical role of nk but not nkt cells in acute rejection of parental bone marrow cells in f1 hybrid mice. EurJImmunol. 31(11):3147–3152.
   Web of Science ®Google Scholar
• Kumar V, George T, Yu YY, Liu J, Bennett M. 1997. Role of murine nk cells and their receptors in hybrid resistance. CurrOpinImmunol. 9(1):52–56.
   Google Scholar
• Cook KD, Whitmire JK. 2013. The depletion of nk cells prevents t cell exhaustion to efficiently control disseminating virus infection. Journal Immunology (Baltimore, Md: 1950). 190(2):641–649. doi:10.4049/jimmunol.1202448.
   PubMed Web of Science ®Google Scholar
• Soderquest K, Walzer T, Zafirova B, Klavinskis LS, Polic B, Vivier E, Lord GM, Martin-Fontecha A. 2011. Cutting edge: cd8+ t cell priming in the absence of nk cells leads to enhanced memory responses. Journal Immunology (Baltimore, Md: 1950). 186(6):3304–3308. doi:10.4049/jimmunol.1004122.
   PubMed Web of Science ®Google Scholar
• Rydyznski C, Ka D, Ep K, Tr B, Se M, Mt M, Li C, Sutiwisesak R, Rm W, Sn W. 2015. Generation of cellular immune memory and b-cell immunity is impaired by natural killer cells. Nat Commun. 6:6375. doi:10.1038/ncomms7375.
   PubMed Web of Science ®Google Scholar
• Cook KD, Kline HC, Whitmire JK. 2015. Nk cells inhibit humoral immunity by reducing the abundance of cd4+ t follicular helper cells during a chronic virus infection. J Leukoc Biol. 98(2):153–162. doi:10.1189/jlb.4HI1214-594R.
   PubMed Web of Science ®Google Scholar
• George T, Yu YY, Liu J, Davenport C, Lemieux S, Stoneman E, Mathew PA, Kumar V, Bennett M. 1997. Allorecognition by murine natural killer cells: lysis of t-lymphoblasts and rejection of bone-marrow grafts. ImmunolRev. 155:29–40.
   Google Scholar
• Van Der Touw W, Bromberg JS. 2010. Natural killer cells and the immune response in solid organ transplantation. AmJTransplant. 10(6):1354–1358.
   Web of Science ®Google Scholar
• Uehara S, Chase CM, Kitchens WH, Rose HS, Colvin RB, Russell PS, Madsen JC. 2005. Nk cells can trigger allograft vasculopathy: the role of hybrid resistance in solid organ allografts. JImmunol. 175(5):3424–3430. doi:10.4049/jimmunol.175.5.3424.
   PubMed Web of Science ®Google Scholar
• Yu G, Xu X, Vu MD, Kilpatrick ED, Li XC. 2006. Nk cells promote transplant tolerance by killing donor antigen-presenting cells. JExpMed. 203(8):1851–1858. doi:10.1084/jem.20060603.
   Google Scholar
• Laffont S, Seillet C, Ortaldo J, Coudert JD, Guery JC. 2008. Natural killer cells recruited into lymph nodes inhibit alloreactive t-cell activation through perforin-mediated killing of donor allogeneic dendritic cells. Blood. 112(3):661–671. doi:10.1182/blood-2007-10-120089.
   PubMed Web of Science ®Google Scholar
• Zecher D, Li Q, Oberbarnscheidt MH, Demetris AJ, Shlomchik WD, Rothstein DM, Lakkis FG. 2010. Nk cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of cd8+ t cells. Journal Immunology (Baltimore, Md: 1950). 184(12):6649–6657. doi:10.4049/jimmunol.0903729.
   PubMed Web of Science ®Google Scholar
• Lantow M, Eggenhofer E, Sabet-Baktach M, Renner P, Rovira J, Koehl GE, Schlitt HJ, Geissler EK, Kroemer A. 2015. Cd27low natural killer cells prolong allograft survival in mice by controlling alloreactive cd8+ t cells in a t-bet-dependent manner. Transplantation. 99(2):391–399. doi:10.1097/TP.0000000000000585.
   PubMed Web of Science ®Google Scholar
• Auchincloss H Jr., Mayer T, Ghobrial R, Winn HJ. 1989. T-cell subsets, bm mutants, and the mechanisms of allogeneic skin graft rejection. ImmunolRes. 8(2):149–164.
   Google Scholar
• Rosenberg AS, Munitz TI, Maniero TG, Singer A. 1991. Cellular basis of skin allograft rejection across a class i major histocompatibility barrier in mice depleted of cd8+ t cells in vivo. JExpMed. 173(6):1463–1471. doi:10.1084/jem.173.6.1463.
   Google Scholar
• Le Moine A, Goldman M, Abramowicz D. 2002. Multiple pathways to allograft rejection. Transplantation. 73(9):1373–1381.
   PubMed Web of Science ®Google Scholar
• Schulze DH, Pease LR, Geier SS, Reyes AA, Sarmiento LA, Wallace RB, Nathenson SG. 1983. Comparison of the cloned h-2kbm1 variant gene with the h-2kb gene shows a cluster of seven nucleotide differences. Proc Natl Acad Sci U S A. 80(7):2007–2011.
   PubMed Web of Science ®Google Scholar
• Waldmann H. 2001. Therapeutic approaches for transplantation. CurrOpinImmunol. 13(5):606–610.
   Google Scholar
• Page EK, Dar WA, Knechtle SJ. 2012. Biologics in organ transplantation. TransplInt. 25(7):707–719. doi:10.1111/j.1432-2277.2012.01456.x.
   Google Scholar
• Ghobrial RR, Boublik M, Winn HJ, Auchincloss H Jr.. 1989. In vivo use of monoclonal antibodies against murine t cell antigens. Clin Immunol Immunopathol. 52(3):486–506.
   PubMedGoogle Scholar
• Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, Roederer M, Koup RA. 2003. Sensitive and viable identification of antigen-specific cd8+ t cells by a flow cytometric assay for degranulation. JImmunolMethods. 281(1–2):65–78.
   PubMed Web of Science ®Google Scholar
• Ossevoort MA, De Bruijn ML, Van Veen KJ, Kast WM, Melief CJ. 1996. Peptide specificity of alloreactive cd4 positive t lymphocytes directed against a major histocompatibility complex class i disparity. Transplantation. 62(10):1485–1491.
   PubMed Web of Science ®Google Scholar
• Oldstone MB. 2002. Biology and pathogenesis of lymphocytic choriomeningitis virus infection. Curr Top Microbiol Immunol. 263:83–117.
   PubMed Web of Science ®Google Scholar
• Pallmer K, Oxenius A. 2016. Recognition and regulation of t cells by nk cells. Front Immunol. 7:251. doi:10.3389/fimmu.2016.00251.
   PubMedGoogle Scholar
• Andrews DM, Estcourt MJ, Andoniou CE, Wikstrom ME, Khong A, Voigt V, Fleming P, Tabarias H, Hill GR, Rg VDM, et al.. 2010. Innate immunity defines the capacity of antiviral t cells to limit persistent infection. J Exp Med. 207(6):1333–1343. doi:10.1084/jem.20091193.
   PubMed Web of Science ®Google Scholar
• Waggoner SN, Cornberg M, Selin LK, Welsh RM. 2011. Natural killer cells act as rheostats modulating antiviral t cells. Nature. 481(7381):394–398. doi:10.1038/nature10624.
   PubMed Web of Science ®Google Scholar
• Freitas AA, Rocha B. 2000. Population biology of lymphocytes: the flight for survival. AnnuRevImmunol. 18:83–111.
   Web of Science ®Google Scholar
• Rocha B, Dautigny N, Pereira P. 1989. Peripheral t lymphocytes: expansion potential and homeostatic regulation of pool sizes and cd4/cd8 ratios in vivo. Eur J Immunol. 19(5):905–911. doi:10.1002/eji.1830190518.
   PubMed Web of Science ®Google Scholar
• Gill RG. 2010. Nk cells: elusive participants in transplantation immunity and tolerance. Curr Opin Immunol. 22(5):649–654. doi:10.1016/j.coi.2010.09.005.
   PubMed Web of Science ®Google Scholar
• Li XC, Demirci G, Ferrari-Lacraz S, Groves C, Coyle A, Malek TR, Strom TB. 2001. Il-15 and il-2: A matter of life and death for t cells in vivo. NatMed. 7(1):114–118.
   PubMed Web of Science ®Google Scholar
• Sun JC, Lanier LL. 2011. Nk cell development, homeostasis and function: parallels with cd8(+) t cells. Nat Reviews Immunol. 11(10):645–657. doi:10.1038/nri3044.
   PubMed Web of Science ®Google Scholar
• Fehniger TA, Cooper MA, Caligiuri MA. 2002. Interleukin-2 and interleukin-15: immunotherapy for cancer. Cytokine Growth Factor Rev. 13(2):169–183. doi:10.1016/S1359-6101(01)00021-1.
   PubMed Web of Science ®Google Scholar
• Rabinovich BA, Li J, Shannon J, Hurren R, Chalupny J, Cosman D, Miller RG. 2003. Activated, but not resting, t cells can be recognized and killed by syngeneic nk cells. Journal Immunology (Baltimore, Md: 1950). 170(7):3572–3576.
   PubMed Web of Science ®Google Scholar
• Lu L, Ikizawa K, Hu D, Werneck MB, Wucherpfennig KW, Cantor H. 2007. Regulation of activated cd4+ t cells by nk cells via the qa-1-nkg2a inhibitory pathway. Immunity. 26(5):593–604. doi:10.1016/j.immuni.2007.03.017.
   PubMed Web of Science ®Google Scholar
• Sn W, Rt T, Pa M, Kumar V, Rm W. 2010. Absence of mouse 2b4 promotes nk cell-mediated killing of activated cd8+ t cells, leading to prolonged viral persistence and altered pathogenesis. J Clin Invest. 120(6):1925–1938. doi:10.1172/JCI41264.
   PubMed Web of Science ®Google Scholar
• Crouse J, Bedenikovic G, Wiesel M, Ibberson M, Xenarios I, Von Laer D, Kalinke U, Vivier E, Jonjic S, Oxenius A. 2014. Type i interferons protect t cells against nk cell attack mediated by the activating receptor ncr1. Immunity. 40(6):961–973. doi:10.1016/j.immuni.2014.05.003.
   PubMed Web of Science ®Google Scholar
• Goldrath AW, Bogatzki LY, Bevan MJ. 2000. Naive t cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. JExpMed. 192(4):557–564. doi:10.1084/jem.192.4.557.
   Google Scholar
• Boyman O, Purton JF, Surh CD, Sprent J. 2007. Cytokines and t-cell homeostasis. CurrOpinImmunol. 19(3):320–326.
   Google Scholar
• Yuan D, Bibi R, Dang T. 2004. The role of adjuvant on the regulatory effects of nk cells on b cell responses as revealed by a new model of nk cell deficiency. Int Immunol. 16(5):707–716. doi:10.1093/intimm/dxh071.
   PubMed Web of Science ®Google Scholar
• Jukes JP, Wood KJ, Jones ND. 2007. Natural killer t cells: A bridge to tolerance or a pathway to rejection? Transplantation. 84(6):679–681. doi:10.1097/01.tp.0000280551.78156.ac.
   PubMed Web of Science ®Google Scholar
• Stober D, Jomantaite I, Schirmbeck R, Reimann J. 2003. Nkt cells provide help for dendritic cell-dependent priming of mhc class i-restricted cd8+ t cells in vivo. Journal Immunology (Baltimore, Md: 1950). 170(5):2540–2548.
   PubMed Web of Science ®Google Scholar
• Wu Z, Bensinger SJ, Zhang J, Chen C, Yuan X, Huang X, Markmann JF, Kassaee A, Rosengard BR, Hancock WW, et al. 2004. Homeostatic proliferation is a barrier to transplantation tolerance. NatMed. 10(1):87–92.
   PubMed Web of Science ®Google Scholar
• Walzer T, Blery M, Chaix J, Fuseri N, Chasson L, Robbins SH, Jaeger S, Andre P, Gauthier L, Daniel L, et al. 2007. Identification, activation, and selective in vivo ablation of mouse nk cells via nkp46. Proc Natl Acad Sci U S A. 104(9):3384–3389. doi:10.1073/pnas.0609692104.
   PubMed Web of Science ®Google Scholar
• Unkeless JC. 1979. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte fc receptors. JExpMed. 150(3):580–596. doi:10.1084/jem.150.3.580.
   Google Scholar
• Rodriguez-Barbosa JI, Fernandez-Renedo C, Moral AMB, Buhler L, Del Rio ML. 2017. T follicular helper expansion and humoral-mediated rejection are independent of the hvem/btla pathway. Cell Mol Immunol. 14(6):497–510. doi:10.1038/cmi.2015.101.
   PubMed Web of Science ®Google Scholar
• Del Rio ML, Cote-Sierra J, Rodriguez-Barbosa JI. 2011. Flt3l-mobilized dendritic cells bearing h2-kbm1 apoptotic cells do not induce cross-tolerance to cd8+ t cells across a class i mhc mismatched barrier. Transpl International: Official Journal Eur Soc Transplant. 24(5):501–513. doi:10.1111/j.1432-2277.2011.01220.x.
   PubMed Web of Science ®Google Scholar
• Lutz MB, Kukutsch N, Ogilvie AL, Rossner S, Koch F, Romani N, Schuler G. 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. JImmunolMethods. 223(1):77–92.
   PubMed Web of Science ®Google Scholar
• Del Rio ML, Jones ND, Buhler L, Norris P, Shintani Y, Ware CF, Rodriguez-Barbosa JI. 2012. Selective blockade of herpesvirus entry mediator-b and t lymphocyte attenuator pathway ameliorates acute graft-versus-host reaction. JImmunol. 188(10):4885–4896. doi:10.4049/jimmunol.1103698.
   PubMed Web of Science ®Google Scholar
• Lyons AB. 2000. Analysing cell division in vivo and in vitro using flow cytometric measurement of cfse dye dilution. JImmunolMethods. 243(1–2):147–154.
   PubMed Web of Science ®Google Scholar
• Del Rio ML, Kurtz J, Perez-Martinez C, Ghosh A, Perez-Simon JA, Rodriguez-Barbosa JI. 2011. B- and t-lymphocyte attenuator targeting protects against the acute phase of graft versus host reaction by inhibiting donor anti-host cytotoxicity. Transplantation. 92(10):1085–1093. doi:10.1097/TP.0b013e3182339d4a.
   PubMed Web of Science ®Google Scholar