References
- France MM, Turner JR. The mucosal barrier at a glance. J Cell Sci. 2017;130:307–11. doi:https://doi.org/10.1242/jcs.193482.
- Brandtzaeg P, Farstad IN, Johansen FE, Morton HC, Norderhaug IN, Yamanaka T. The B-cell system of human mucosae and exocrine glands. Immunol Rev. 1999;171:45–87. doi:https://doi.org/10.1111/j.1600-065X.1999.tb01342.x.
- Leusen JH. IgA as therapeutic antibody. Mol Immunol. 2015;68:35–39. doi:https://doi.org/10.1016/j.molimm.2015.09.005.
- Hansen IS, Baeten DLP, den Dunnen J. The inflammatory function of human IgA. Cell Mol Life Sci. 2019;76:1041–55. doi:https://doi.org/10.1007/s00018-018-2976-8.
- Lewis MJ, Pleass RJ, Batten MR, Atkin JD, Woof JM. Structural requirements for the interaction of human IgA with the human polymeric Ig receptor. J Immunol. 2005;175:6694–701. doi:https://doi.org/10.4049/jimmunol.175.10.6694.
- Woof JM, Russell MW. Structure and function relationships in IgA. Mucosal Immunol. 2011;4:590–97. doi:https://doi.org/10.1038/mi.2011.39.
- Kaetzel CS. The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces. Immunol Rev. 2005;206:83–99. doi:https://doi.org/10.1111/imr.2005.206.issue-1.
- Stadtmueller BM, Huey-Tubman KE, Lopez CJ, Yang Z, Hubbell WL, Bjorkman PJ. The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins. Elife. 2016;5:e10640. doi:https://doi.org/10.7554/eLife.10640.
- Bonner A, Almogren A, Furtado PB, Kerr MA, Perkins SJ. Location of secretory component on the Fc edge of dimeric IgA1 reveals insight into the role of secretory IgA1 in mucosal immunity. Mucosal Immunol. 2009;2:74–84. doi:https://doi.org/10.1038/mi.2008.68.
- Kaetzel CS. Polymeric Ig receptor: defender of the fort or Trojan horse? Curr Biol. 2001;11:R35–8. doi:https://doi.org/10.1016/S0960-9822(00)00041-5.
- Johansen FE, Kaetzel CS. Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity. Mucosal Immunol. 2011;4:598–602. doi:https://doi.org/10.1038/mi.2011.37.
- Lombana TN, Rajan S, Zorn JA, Mandikian D, Chen EC, Estevez A, Yip V, Bravo DD, Phung W, Farahi F, et al. Production, characterization, and in vivo half-life extension of polymeric IgA molecules in mice. MAbs. 2019;11:1122–38. doi:https://doi.org/10.1080/19420862.2019.1622940.
- Turula H, Wobus CE. The role of the polymeric immunoglobulin receptor and secretory immunoglobulins during mucosal infection and immunity. Viruses. 2018;10(5):e237. doi:https://doi.org/10.3390/v10050237.
- Bakema JE, van Egmond M, Immunoglobulin A. A next generation of therapeutic antibodies? MAbs. 2011;3:352–61. doi:https://doi.org/10.4161/mabs.3.4.16092.
- Borrok MJ, DiGiandomenico A, Beyaz N, Marchetti GM, Barnes AS, Lekstrom KJ, Phipps SS, McCarthy MP, Wu H, Dall’Acqua WF, et al. Enhancing IgG distribution to lung mucosal tissue improves protective effect of anti-Pseudomonas aeruginosa antibodies. JCI Insight. 2018;3(12):e97844. doi:https://doi.org/10.1172/jci.insight.97844.
- White KD, Capra JD. Targeting mucosal sites by polymeric immunoglobulin receptor-directed peptides. J Exp Med. 2002;196:551–55. doi:https://doi.org/10.1084/jem.20020581.
- Braathen R, Sandvik A, Berntzen G, Hammerschmidt S, Fleckenstein B, Sandlie I, Brandtzaeg P, Johansen F-E, Lauvrak V. Identification of a polymeric Ig receptor binding phage-displayed peptide that exploits epithelial transcytosis without dimeric IgA competition. J Biol Chem. 2006;281:7075–81. doi:https://doi.org/10.1074/jbc.M508509200.
- Ferkol T, Kaetzel CS, Davis PB. Gene transfer into respiratory epithelial cells by targeting the polymeric immunoglobulin receptor. J Clin Invest. 1993;92:2394–400. doi:https://doi.org/10.1172/JCI116845.
- Ferkol T, Perales JC, Eckman E, Kaetzel CS, Hanson RW, Davis PB. Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor. J Clin Invest. 1995;95:493–502. doi:https://doi.org/10.1172/JCI117690.
- Eckman EA, Mallender WD, Szegletes T, Silski CL, Schreiber JR, Davis PB, Ferkol TW. In vitro transport of active alpha(1)-antitrypsin to the apical surface of epithelia by targeting the polymeric immunoglobulin receptor. Am J Respir Cell Mol Biol. 1999;21:246–52. doi:https://doi.org/10.1165/ajrcmb.21.2.3687.
- Ferkol T, Eckman E, Swaidani S, Silski C, Davis P. Transport of bifunctional proteins across respiratory epithelial cells via the polymeric immunoglobulin receptor. Am J Respir Crit Care Med. 2000;161:944–51. doi:https://doi.org/10.1164/ajrccm.161.3.9907018.
- Gupta S, Eastman J, Silski C, Ferkol T, Davis PB. Single chain Fv: a ligand in receptor-mediated gene delivery. Gene Ther. 2001;8:586–92. doi:https://doi.org/10.1038/sj.gt.3301451.
- Ferkol T, Cohn LA, Phillips TE, Smith A, Davis PB. Targeted delivery of antiprotease to the epithelial surface of human tracheal xenografts. Am J Respir Crit Care Med. 2003;167:1374–79. doi:https://doi.org/10.1164/rccm.200209-1119OC.
- Gupta S, Heacock M, Perez A, Davis PB. Antibodies to the polymeric immunoglobulin receptor with different binding and trafficking patterns. Am J Respir Cell Mol Biol. 2005;33:363–70. doi:https://doi.org/10.1165/rcmb.2005-0132OC.
- Emmerson CD, van der Vlist EJ, Braam MR, Vanlandschoot P, Merchiers P, de Haard HJ, Verrips CT, van Bergen En Henegouwen PMP, Dolk E. Enhancement of polymeric immunoglobulin receptor transcytosis by biparatopic VHH. PLoS One. 2011;6:e26299. doi:https://doi.org/10.1371/journal.pone.0026299.
- Ying T, Chen W, Gong R, Feng Y, Dimitrov DS. Soluble monomeric IgG1 Fc. J Biol Chem. 2012;287:19399–408. doi:https://doi.org/10.1074/jbc.M112.368647.
- O’Brien LE, Zegers MM, Mostov KE. Opinion: building epithelial architecture: insights from three-dimensional culture models. Nat Rev Mol Cell Biol. 2002;3:531–37. doi:https://doi.org/10.1038/nrm859.
- Ren D, Daines DA. Use of the EpiAirway model for characterizing long-term host-pathogen interactions. J Vis Exp. 2011;(55):e3261. doi:https://doi.org/10.3791/3261.
- Jackson GR Jr., Maione AG, Klausner M, Hayden PJ. Prevalidation of an acute inhalation toxicity test using the epiairway In Vitro human airway model. Appl In Vitro Toxicol. 2018;4:149–58. doi:https://doi.org/10.1089/aivt.2018.0004.
- Hamburger AE, West AP Jr., Bjorkman PJ. Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor. Structure. 2004;12:1925–35. doi:https://doi.org/10.1016/j.str.2004.09.006.
- Hamburger AE, Bjorkman PJ, Herr AB. Structural insights into antibody-mediated mucosal immunity. Curr Top Microbiol Immunol. 2006;308:173–204. doi:https://doi.org/10.1007/3-540-30657-9_8.
- Akula S, Mohammadamin S, Hellman L. Fc receptors for immunoglobulins and their appearance during vertebrate evolution. PLoS One. 2014;9:e96903. doi:https://doi.org/10.1371/journal.pone.0096903.
- Van Bockstaele F, Holz JB, Revets H. The development of nanobodies for therapeutic applications. Curr Opin Investig Drugs. 2009;10:1212–24.
- Muyldermans S. Nanobodies: natural single-domain antibodies. Annu Rev Biochem. 2013;82:775–97. doi:https://doi.org/10.1146/annurev-biochem-063011-092449.
- Jerdeva GV, Tesar DB, Huey-Tubman KE, Ladinsky MS, Fraser SE, Bjorkman PJ. Comparison of FcRn- and pIgR-mediated transport in MDCK cells by fluorescence confocal microscopy. Traffic. 2010;11:1205–20. doi:https://doi.org/10.1111/j.1600-0854.2010.01083.x.
- Zhang JR, Mostov KE, Lamm ME, Nanno M, Shimida S, Ohwaki M, Tuomanen E. The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells. Cell. 2000;102:827–37. doi:https://doi.org/10.1016/S0092-8674(00)00071-4.