550
Views
16
CrossRef citations to date
0
Altmetric
Articles

Determination of ractopamine residue in tissues and urine from pig fed meat and bone meal

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 424-433 | Received 14 Sep 2018, Accepted 06 Jan 2019, Published online: 20 Feb 2019

References

  • [ABPA] Brazilian Association of Animal Protein. 2017 Annual report of the Brazilian Association of Animal Protein. São Paulo. www.abpa-br.org
  • Alemanno A, Capodieci G. 2012. Testing the limits of global food governance: the case of ractopamine. Eur J Risk Regul. 3:400–407.
  • Almeida VV, Costa Nunez AJ, Miyada VS. 2012. Ractopamine as a metabolic modifier feed additive for finishing pigs: a review. Braz Arch Biol Technol. 55:445–456.
  • Antignac J-P, Marchand P, Le Bizec B, Andre F. 2002. Identification of ractopamine residues in tissue and urine samples at ultra-trace level using liquid chromatography–positive electrospray tandem mass spectrometry. J Chromatogr B. 774:59–66.
  • Athayde NB, Dalla Costa OA, Roca RO, Guidoni AL, Ludtke CB, Lima GJMM. 2012. Meat quality of swine supplemented with ractopamine under commercial conditions in Brazil. J Anim Sci. 90:4604–4610.
  • Beermann DH, editor. 2014. Meat, animal, poultry and fish production and management beta-agonists. In: Encyclopedia of meat sciences. 2nd ed. London: Elsevier. p.177–180. http://linkinghub.elsevier.com/retrieve/pii/B9780123847317000179.
  • Bohrer BM, Kyle JM, Boler DD, Rincker PJ, Ritter MJ, Carr SN. 2013. Meta-analysis of the effects of ractopamine hydrochloride on carcass cutability and primal yields of finishing pigs. J Anim Sci. 91:1015–1023.
  • Brazilian Renderers. 2016. II Diagnosis of the Brazilian rendering industry. Brazilian Renderers. Brasília, DF (Brazil): ABRA (Associação Brasileira de Reciclagem Animal). p. 1–88. http://brazilianrenderers.com/en/views/downloads/II_Diagnostico_da_Industria_Brasileira_de_Reciclagem_Animal_-_EN.pdf.
  • Burnett TJ, Rodewald JM, Moran J, Turberg MP, Brunelle SL, Coleman MR. 2012. Determination of ractopamine in swine, bovine, and turkey tissues by HPLC with fluorescence detection: first action 2011.22. J AOAC Int. 95:945–958.
  • Cantarelli V de S, Fialho ET, Almeida EC de, Zangeronimo MG, Rodrigues PB, FreitasRTF de. 2009. Ractopamine for finishing barrows fed restricted or ad libitum diets: performance and nitrogen balance. Rev Bras Zootec. 38:2375–2382.
  • Chang KC, Chang YT, Tsai CE. 2018. Determination of ractopamine and salbutamol in pig hair by liquid chromatography tandem mass spectrometry. J Food Drug Anal. 26:725–730.
  • Dalidowicz JE, Babbitt MS. 1986. Characterization of 14C-residues in tissues and excreta from swine fed 14C-ractopamine HCl. Lilly Research Laboratories, Division of Eli Lilly and Company. No. ABC-0355 158. Unpublished report on study RACTOPAMINE Agricultural Biochemistry.
  • Dalla Costa OA, Feddern V, Athayde NB, Manzke NE, Roça RO, Lopes LS, Lima GJMMD. 2018. Ractopamine supplementation improves leanness and carcass yield, minimally affecting pork quality in immunocastrated pigs. Sci Agric. 75:197–207.
  • Dong Y, Xia X, Wang X, Ding S, Li X, Zhang S, Jiang H, Liu J, Li J, Feng Z, et al. 2011. Validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for determination of ractopamine: application to residue depletion study in swine. Food Chem. 127:327–332.
  • Dunshea FR, D’Souza DN, Pethick DW, Harper GS, Warner RD. 2005. Effects of dietary factors and other metabolic modifiers on quality and nutritional value of meat. Meat Sci. 71:8–38.
  • [EFSA] European Food Safety Authority. 2009. Safety evaluation of ractopamine. Scientific opinion of the panel on additives and products or substances used in animal feed (FEEDAP) on a request from the European commission on the safety evaluation of ractopamine. EFSA J. 1041:1–52.
  • European Commision. 1996. 96/23/EC residue directive. Off J Eur Communities. L125:10–32.
  • Feddern V, Aroeira CN, Molognoni L, Gressler V, Daguer H, Dalla Costa OA, Castillo CJC, de Lima GJMM. 2018. Ractopamine analysis in pig kidney, liver and lungs: a validation of the method scope extension using QuEChERS as a sample preparation step. J Chromatogr B. 1091:79–86.
  • Freire EF, Borges KB, Tanimoto H, Nogueira RT, Bertolini LCT, Gaitani CM. 2013. Monitoring of ractopamine concentration in the mixture of this feed additive with vitamin mineral complex and with swine feed by HPLC. Food Addit Contam Part A. 30:796–803.
  • Gottlob RO, Hastad CW, Lawrence KR, Groesbeck CN, Goodband RD, Tokach MD, DeRouchey JM, Nelssen JL, Dritz S. 2004. Effects of increasing meat and bone meal on finishing-pig growth performance. Manhattan, KS: New Prairie PressKansas Agricultural Experiment Station Research Reports. Vol. 0, Iss. 10. doi:10.4148/2378-5977.6918. http://newprairiepress.org/cgi/viewcontent.cgi?article=6918&context=kaesrr.
  • Gressler V, Feddern V, Peixoto JO, Ledur MC, Dalla Costa OA, Lima GJMM. 2018. Application of enzyme digestion and deconjugation followed by quick, easy, cheap, effective, rugged, safe extraction and liquid chromatography–tandem mass spectrometry methodology to determine ractopamine residue in pork. J Food Prot. 81:1258–1263.
  • Gressler V, Franzen ARL, Lima GJMM, Tavernari FC, Dalla Costa OA, Feddern V. 2016. Development of a readily applied method to quantify ractopamine residue in meat and bone meal by QuEChERS-LC–MS/MS. J Chromatogr B. 1015–1016:192–200.
  • Ho JK, Huo TI, Lin LC, Tsai TH. 2014. Pharmacokinetics of ractopamine and its organ distribution in rats. J Agric Food Chem. 62:9273–9278.
  • Jayathilakan K, Sultana K, Radhakrishna K, Bawa AS. 2012. Utilization of byproducts and waste materials from meat, poultry and fish processing industries: a review. J Food Sci Technol. 49:278–293.
  • [JECFA] Joint FAO/WHO Expert Committee on Food Additives. 2012. Information sheet – discussion on ractopamine in codex and in the joint FAO/WHO expert committee on food additives (JECFA) (prepared by the Codex and JECFA Secretariats). 1:1–2. http://www.fao.org/fileadmin/user_upload/agns/pdf/Ractopamine_info_sheet_Codex-JECFA_rev_26April2012__2_.pdf.
  • Johnson CJ, McKenzie D, Pedersen JA, Aiken JM. 2011. Meat and bone meal and mineral feed additives may increase the risk of oral prion disease transmission. J Toxicol Environ Health Part A. 74:161–166.
  • Karakas P, Versteegh HAJ, Van Der Honing Y, Kogut J, Jongbloed AW. 2001. Nutritive value of the meat and bone meals from cattle or pigs in broiler diets. Poult Sci. 80:1180–1189.
  • Li MH, Bosworth BG, Lucas PM. 2018. Evaluation of porcine meat and bone meal in diets for pond-raised hybrid catfish. N Am J Aquac. 80:69–73.
  • Mills SE, Spurlock ME, Smith DJ. 2003. β-Adrenergic receptor subtypes that mediate ractopamine stimulation of lipolysis. J Anim Sci. 81:662–668.
  • Mimbs KJ, Pringle TD, Azain MJ, Meers SA, Armstrong TA. 2005. Effects of ractopamine on performance and composition of pigs phenotypically sorted into fat and lean groups. J Anim Sci. 83:1361–1369.
  • Ministry of Agriculture, Livestock and Food Supply. 2015. Tabela de aditivos antimicrobianos, anticoccidianos e agonistas com uso autorizado na alimentação animal. [Table of antimicrobial additives, anticoccidials and agonists with authorized use in animal feed]. Brazil: Ministry of Agriculture, Livestock and Food Supply. p.9. http://www.agricultura.gov.br/assuntos/insumos-agropecuarios/insumos-pecuarios/alimentacao-animal/aditivos.
  • Ministry of Agriculture, Livestock and Food Supply. 2016. National plan of residues and contaminants control. results of the national plan on control of residues and contaminants - PNCRC http://www.agricultura.gov.br/assuntos/inspecao/produtos-animal/plano-de-nacional-de-controle-de-residuos-e-contaminantes/documentos-da-pncrc/resultados-pncrc-2016-english-version.pdf
  • Montes Nino AM, Granja RHMM, Reche KVG, Giannotti FM, de Souza JKG, Ferrari SPG, dos Santos AD, Wanschel ACBA, Salerno AG. 2017. Laboratory validation of an LC-MS/MS method for the detection of ractopamine, clenbuterol and salbutamol in bovine and swine muscle at sub-μg kg–1 regulatory limits. Food Addit Contam - Part A. 34:785–792.
  • Moody DE, Hancock DL, Anderson DB. 2010. Phenylethanolamine repartitioning agents. In: D'Mello JPF, editor. Farm animal metabolism and nutrition. Wallingford (Oxon, UK): CAB International. p. 65–96. doi:10.1079/9780851993782.0065
  • [NRC] National Research Council. 2012. National research council. Nutrient requirements of swine. 11 revised. Washington, D.C. 20418. USA:National Academic Press.
  • Pleadin J, Vulic A, Perai N, Terzic S, Andriaic M, Žarkovic I, Šandor K, Perak E. 2012. Comparison of ractopamine accumulation in tissues on days after treatment. Toxicol Lett. 211:S95–S96.
  • Qiang Z, Shentu F, Wang B, Wang J, Chang J, Shen J. 2007. Residue depletion of ractopamine and its metabolites in swine tissues, urine, and serum. J Agric Food Chem. 55:4319–4326.
  • Rikard-Bell C, Curtis MA, van Barneveld RJ, Mullan BP, Edwards AC, Gannon NJ, Henman DJ, Hughes PE, Dunshea FR. 2009. Ractopamine hydrochloride improves growth performance and carcass composition in immunocastrated boars, intact boars, and gilts. J Anim Sci. 87:3536–3543.
  • Ritter MJ, Johnson AK, Benjamin ME, Carr SN, Ellis M, Faucitano L, Grandin T, Salak-Johnson JL, Thomson DU, Goldhawk C, et al. 2017. Review: effects of ractopamine hydrochloride (Paylean) on welfare indicators for market weight pigs. Transl Anim Sci. 1:412–425.
  • Rostagno HS, Albino LFT, Donzele JL, Gomes PC, Oliveira RF, Lopes DC, Ferreira AS, Barreto SLT, Euclides RF. 2011. Brazilian tables for poultry and swine: composition of feedstuffs and nutritional requirements. In: Rostagno HS, editor; Becker BG, translator. 3rd. ed. Viçosa (MG): UFV, DZO. 251 p.
  • Sas Institute Inc. 2012. System for microsoft windows, release 9.4 (CD-ROM). Cary (NC): Sas Institute Inc.
  • Thompson CS, Haughey SA, Traynor IM, Fodey TL, Elliott CT, Antignac J-P, Le Bizec BL, Crooks SRH. 2008. Effective monitoring for ractopamine residues in samples of animal origin by SPR biosensor and mass spectrometry. Anal Chim Acta. 608:217–225.
  • Ulrey WD, Burnett TJ, Brunelle SL, Lombardi KR, Coleman MR. 2013. Determination and confirmation of parent and total ractopamine in bovine, swine, and turkey tissues by liquid chromatography with tandem mass spectrometry: final action 2011.23. J AOAC Int. 96:917–924.
  • Ungemach FR. 2004. WHO food additives series: 53. Ractopamine (addendum). IPCS Inchem. 1:1–46. http://www.inchem.org/documents/jecfa/jecmono/v53je08.htm.
  • Valese AC, Oliveira GAP, Kleemann CR, Molognoni L, Daguer H. 2016. A QuEChERS/LC–MS method for the analysis of ractopamine in pork. J Food Compos Anal. 47:38–44.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.