Hemolysin BL from novel Bacillus toyonensis BV-17 induces antitumor activity both in vitro and in vivo

References

• Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–15. doi:10.3322/caac.21492.
   PubMed Web of Science ®Google Scholar
• Wong SH, Zhao L, Zhang X, Nakatsu G, Han J, Xu W, Xiao X, Kwong TNY, Tsoi H, Wu WKK, et al. Gavage of fecal samples from patients with colorectal cancer promotes intestinal carcinogenesis in germ-free and conventional mice. Gastroenterology. 2017;153(6):1621–1633 e6. doi:10.1053/j.gastro.2017.08.022.
   PubMed Web of Science ®Google Scholar
• Yu J, Feng Q, Wong SH, Zhang D, Liang QY, Qin Y, Tang L, Zhao H, Stenvang J, Li Y, et al. Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer. Gut. 2017;66(1):70–78. doi:10.1136/gutjnl-2015-309800.
   PubMed Web of Science ®Google Scholar
• Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillere R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 2018;359:91–97. doi:10.1126/science.aan3706.
   PubMed Web of Science ®Google Scholar
• Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV, Prieto PA, Vicente D, Hoffman K, Wei SC, et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science. 2018;359:97–103. doi:10.1126/science.aan4236.
   PubMed Web of Science ®Google Scholar
• Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y, Narushima S, Vlamakis H, Motoo I, Sugita K, et al. A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. Nature. 2019;565(7741):600–605. doi:10.1038/s41586-019-0878-z.
   PubMed Web of Science ®Google Scholar
• Coley WB. The Treatment of Inoperable Sarcoma by Bacterial Toxins (the Mixed Toxins of the Streptococcus erysipelas and the Bacillus prodigiosus). Proc R Soc Med. 1910;3:1–48.
   PubMedGoogle Scholar
• Babjuk M, Burger M, Zigeuner R, Shariat SF, van Rhijn BW, Comperat E, Sylvester RJ, Kaasinen E, Bohle A, Palou Redorta J, et al. EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2013. Eur Urol. 2013;64:639–653. doi:10.1016/j.eururo.2013.06.003.
   PubMed Web of Science ®Google Scholar
• Su Y, Ortiz J, Liu S, Bugge TH, Singh R, Leppla SH, Frankel AE. Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice. Cancer Res. 2007;67:3329–3336. doi:10.1158/0008-5472.CAN-06-4642.
   PubMed Web of Science ®Google Scholar
• Pastan I, Hassan R, Fitzgerald DJ, Kreitman RJ. Immunotoxin therapy of cancer. Nat Rev Cancer. 2006;6(7):559–565. doi:10.1038/nrc1891.
   PubMed Web of Science ®Google Scholar
• Kreitman RJ, Wilson WH, White JD, Stetler-Stevenson M, Jaffe ES, Giardina S, Waldmann TA, Pastan I. Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies. J Clin Oncol. 2000;18(8):1622–1636. doi:10.1200/JCO.2000.18.8.1622.
   PubMed Web of Science ®Google Scholar
• Jimenez G, Urdiain M, Cifuentes A, Lopez-Lopez A, Blanch AR, Tamames J, Kampfer P, Kolsto AB, Ramon D, Martinez JF, et al. Description of Bacillus toyonensis sp. nov., a novel species of the Bacillus cereus group, and pairwise genome comparisons of the species of the group by means of ANI calculations. Syst Appl Microbiol. 2013;36:383–391. doi:10.1016/j.syapm.2013.04.008.
   PubMed Web of Science ®Google Scholar
• Kantas D, Papatsiros VG, Tassis PD, Giavasis I, Bouki P, Tzika ED. A feed additive containing Bacillus toyonensis (Toyocerin((R))) protects against enteric pathogens in postweaning piglets. J Appl Microbiol. 2015;118:727–738. doi:10.1111/jam.12729.
   PubMed Web of Science ®Google Scholar
• Santos FDS, Menegon YA, Piraine REA, Rodrigues PRC, Cunha RC, Leite FPL. Bacillus toyonensis improves immune response in the mice vaccinated with recombinant antigen of bovine herpesvirus type 5. Benef Microbes. 2018;9(1):133–142. doi:10.3920/BM2017.0021.
   PubMed Web of Science ®Google Scholar
• Scharek-Tedin L, Pieper R, Vahjen W, Tedin K, Neumann K, Zentek J. Bacillus cereus var. Toyoi modulates the immune reaction and reduces the occurrence of diarrhea in piglets challenged with Salmonella Typhimurium DT104. J Anim Sci. 2013;91(12):5696–5704. doi:10.2527/jas.2013-6382.
   PubMed Web of Science ®Google Scholar
• Abdulmawjood A, Herrmann J, Riede S, Jimenez G, Becker A, Breves G. Evaluation of enterotoxin gene expression and enterotoxin production capacity of the probiotic strain Bacillus toyonensis BCT-7112T. PLoS One. 2019;14:e0214536. doi:10.1371/journal.pone.0214536.
   PubMed Web of Science ®Google Scholar
• Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027–1031. doi:10.1038/nature05414.
   PubMed Web of Science ®Google Scholar
• Chung H, Pamp SJ, Hill JA, Surana NK, Edelman SM, Troy EB, Reading NC, Villablanca EJ, Wang S, Mora JR, et al. Gut immune maturation depends on colonization with a host-specific microbiota. Cell. 2012;149(7):1578–1593. doi:10.1016/j.cell.2012.04.037.
   PubMed Web of Science ®Google Scholar
• Feng Q, Liang S, Jia H, Stadlmayr A, Tang L, Lan Z, Zhang D, Xia H, Xu X, Jie Z, et al. Gut microbiome development along the colorectal adenoma-carcinoma sequence. Nat Commun. 2015;6:6528. doi:10.1038/ncomms7528.
   PubMed Web of Science ®Google Scholar
• Yahav S, Berkovich Z, Ostrov I, Reifen R, Shemesh M. Encapsulation of beneficial probiotic bacteria in extracellular matrix from biofilm-forming Bacillus subtilis. Artif Cells Nanomed Biotechnol. 2018;46(sup2):974–982. doi:10.1080/21691401.2018.1476373.
   PubMed Web of Science ®Google Scholar
• Cao GT, Dai B, Wang KL, Yan Y, Xu YL, Wang YX, Yang CM. Bacillus licheniformis, a potential probiotic, inhibits obesity by modulating colonic microflora in C57BL/6J mice model. J Appl Microbiol. 2019;127(3):880–888. doi:10.1111/jam.14352.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Yuan L, Wan J, Sun Z, Wang Y, Sun H. Effects of potential probiotic Bacillus cereus EN25 on growth, immunity and disease resistance of juvenile sea cucumber Apostichopus japonicus. Fish Shellfish Immunol. 2016;49:237–242. doi:10.1016/j.fsi.2015.12.035.
   PubMed Web of Science ®Google Scholar
• Kovac J, Miller RA, Carroll LM, Kent DJ, Jian J, Beno SM, Wiedmann M. Production of hemolysin BL by Bacillus cereus group isolates of dairy origin is associated with whole-genome phylogenetic clade. BMC Genomics. 2016;17(1):581. doi:10.1186/s12864-016-2883-z.
   PubMedGoogle Scholar
• Beecher DJ, Macmillan JD. Characterization of the components of hemolysin BL from Bacillus cereus. Infect Immun. 1991;59:1778–1784. doi:10.1128/IAI.59.5.1778-1784.1991.
   PubMed Web of Science ®Google Scholar
• Jessberger N, Dietrich R, Schwemmer S, Tausch F, Schwenk V, Didier A, Martlbauer E. Binding to the target cell surface is the crucial step in pore formation of hemolysin BL from Bacillus cereus. Toxins (Basel). 2019;11(5):281. doi:10.3390/toxins11050281.
   Web of Science ®Google Scholar
• Mathur A, Feng S, Hayward JA, Ngo C, Fox D, Atmosukarto II, Price JD, Schauer K, Martlbauer E, Robertson AAB, et al. A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome. Nat Microbiol. 2019;4(2):362–374. doi:10.1038/s41564-018-0318-0.
   PubMed Web of Science ®Google Scholar
• Wang Q, Wang Y, Ding J, Wang C, Zhou X, Gao W, Huang H, Shao F, Liu Z. A bioorthogonal system reveals antitumour immune function of pyroptosis. Nature. 2020. doi:10.1038/s41586-020-2079-1.
   Web of Science ®Google Scholar
• Gil M, Kim KE. Interleukin-18 is a prognostic biomarker correlated with CD8+ T cell and natural killer cell infiltration in skin cutaneous melanoma. J Clin Med. 2019;8(11):1993. doi:10.3390/jcm8111993.
   Web of Science ®Google Scholar