Advanced search
Publication Cover
Gut Microbes Volume 12, 2020 - Issue 1
Submit an article Journal homepage
2,063
Views
17
CrossRef citations to date
0
Altmetric
Brief Report

The role of gut vascular barrier in experimental alcoholic liver disease and A. muciniphila supplementation

Christoph Grandera Department of Internal Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University Innsbruck, Innsbruck, AustriaORCID Iconhttps://orcid.org/0000-0003-2971-6224View further author information
ORCID Icon,
Felix Grabherra Department of Internal Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University Innsbruck, Innsbruck, AustriaView further author information
,
Ilaria Spadonib Department of Biomedical Sciences, Humanitas University, Milan, ItalyView further author information
,
Barbara Enricha Department of Internal Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University Innsbruck, Innsbruck, AustriaView further author information
,
Georg Oberhuberc INNPATH, Institute of Pathology, University Hospital of Innsbruck, Innsbruck, AustriaView further author information
,
Maria Rescignob Department of Biomedical Sciences, Humanitas University, Milan, Italy;d Humanitas Clinical and Research Center-IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, ItalyView further author information
&
Herbert Tilga Department of Internal Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University Innsbruck, Innsbruck, AustriaCorrespondence[email protected]
View further author information
 show all
Article: 1851986 | Received 06 Oct 2020, Accepted 08 Nov 2020, Published online: 01 Dec 2020

References

  • Maccioni L, Gao B, Leclercq S, Pirlot B, Horsmans Y, De Timary P, Leclercq I, Fouts D, Schnabl B, Stärkel P, et al. Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans. Gut Microb. 2020;12:1782157. doi:10.1080/19490976.2020.1782157.
  • Bode C, Bode JC. Effect of alcohol consumption on the gut. Best Pract Res Clin Gastroenterol. 2003;17:575–592. doi:10.1016/S1521-6918(03)00034-9.
  • Avila MA, Dufour JF, Gerbes AL, Zoulim F, Bataller R, Burra P, Cortez-Pinto H, Gao B, Gilmore I, Mathurin P, et al. Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting. Gut. 2020;69:764–780. doi:10.1136/gutjnl-2019-319720.
  • Zhou Z, Zhong W. Targeting the gut barrier for the treatment of alcoholic liver disease. Liver Res. 2017;1:197–207. doi:10.1016/j.livres.2017.12.004.
  • Grander C, Adolph TE, Wieser V, Lowe P, Wrzosek L, Gyongyosi B, Ward DV, Grabherr G, Gerner RR, Pfister A, et al. Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease. Gut.2018;67:891–900.
  • Spadoni I, Zagato E, Bertocchi A, Paolinelli R, Hot E, Di Sabatino A, Caprioli F, Bottiglieri L, Oldani A, Viale G, et al. A gut-vascular barrier controls the systemic dissemination of bacteria. Science (New York, NY). 2015;350:830–834. doi:10.1126/science.aad0135.
  • Hartmann P, Chen WC, Schnabl B. The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease. Front Physiol. 2012;3:402. doi:10.3389/fphys.2012.00402.
  • Yan AW, Schnabl B. Bacterial translocation and changes in the intestinal microbiome associated with alcoholic liver disease. World J Hepatol. 2012;4:110–118. doi:10.4254/wjh.v4.i4.110.
  • Wang L, Fouts DE, Stärkel P, Hartmann P, Chen P, Llorente C, DePew J, Moncera K, Ho S, Brenner D, et al. Intestinal REG3 lectins protect against alcoholic steatohepatitis by reducing mucosa-associated microbiota and preventing bacterial translocation. Cell Host Microbe. 2016;19:227–239. doi:10.1016/j.chom.2016.01.003.
  • Hendrikx T, Duan Y, Wang Y, Oh JH, Alexander LM, Huang W, Stärkel P, Ho SB, Gao B, Fiehn O, et al. Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice. Gut. 2019;68:1504–1515. doi:10.1136/gutjnl-2018-317232.
  • Sorribas M, Jakob MO, Yilmaz B, Li H, Stutz D, Noser Y, de Gottardi A, Moghadamrad S, Hassan M, Albillos A, et al. FXR modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis. J Hepatol. 2019;71:1126–1140. doi:10.1016/j.jhep.2019.06.017.
  • Mouries J, Brescia P, Silvestri A, Spadoni I, Sorribas M, Wiest R, Mileti E, Galbiati M, Invernizzi P, Adorini L, et al. Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development. J Hepatol. 2019;71(6):1216–1228. doi:10.1016/j.jhep.2019.08.005.
  • Li Y, Zhou J, Qiu J, Huang Z, Wang W, Wu P, Feng A. Berberine reduces gut-vascular barrier permeability via modulation of ApoM/S1P pathway in a model of polymicrobial sepsis. Life Sci. 2020;261:118460. doi:10.1016/j.lfs.2020.118460.
  • Tiruppathi C, Shimizu J, Miyawaki-Shimizu K, Vogel SM, Bair AM, Minshall RD, Predescu D, Malik AB. Role of NF-kappaB-dependent caveolin-1 expression in the mechanism of increased endothelial permeability induced by lipopolysaccharide. J Biol Chem. 2008;283:4210–4218. doi:10.1074/jbc.M703153200.
  • Shue EH, Carson-Walter EB, Liu Y, Winans BN, Ali ZS, Chen J, Walter KA. Plasmalemmal vesicle associated protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models. BMC Neurosci. 2008;9:29. doi:10.1186/1471-2202-9-29.
  • Bertola A, Mathews S, Ki SH, Wang H, Gao B. Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nat Protoc. 2013;8:627–637. doi:10.1038/nprot.2013.032.
  • Hartmann P, Chen P, Wang HJ, Wang L, McCole DF, Brandl K, Stärkel P, Belzer C, Hellerbrand C, Tsukamoto H, et al. Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice. Hepatology. 2013;58(1):108–119. doi:10.1002/hep.26321.
  • Harada N, Tamai Y, Ishikawa T, Sauer B, Takaku K, Oshima M, Taketo MM, et al. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. Embo J. 1999;18:5931–5942. doi:10.1093/emboj/18.21.5931.
  • Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Lüthi U, et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature. 2010;465:483–486. doi:10.1038/nature09002.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.