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Editorial

Amino acid biosynthetic pathways as antifungal targets for fungal infections

Pages 376-378 | Received 14 Mar 2016, Accepted 16 Mar 2016, Published online: 30 Mar 2016

References

  • Denning DW. Invasive aspergillosis. Clin Infect Dis 1998; 26:781-803; PMID:9564455; http://dx.doi.org/10.1086/513943
  • Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, White TC. Hidden killers: human fungal infections. Sci Transl Med 2012; 4:165rv13; PMID:23253612
  • Ermishkin LN, Kasumov KM, Potzeluyev VM. Single ionic channels induced in lipid bilayers by polyene antibiotics amphotericin B and nystatine. Nature 1976; 262:698-9; PMID:958440; http://dx.doi.org/10.1038/262698a0
  • Denning DW. Echinocandin antifungal drugs. Lancet 2003; 362:1142-51; PMID:14550704; http://dx.doi.org/10.1016/S0140-6736(03)14472-8
  • Perlin DS. Resistance to echinocandin-class antifungal drugs. Drug Resist Updat 2007; 10:121-30; PMID:17569573; http://dx.doi.org/10.1016/j.drup.2007.04.002
  • Jastrzebowska K, Gabriel I. Inhibitors of amino acids biosynthesis as antifungal agents. Amino Acids 2015; 47:227-49; PMID:25408465; http://dx.doi.org/10.1007/s00726-014-1873-1
  • Liebmann B, Muhleisen TW, Muller M, Hecht M, Weidner G, Braun A, et al. Deletion of the Aspergillus fumigatus lysine biosynthesis gene lysF encoding homoaconitase leads to attenuated virulence in a low-dose mouse infection model of invasive aspergillosis. Arch Microbiol 2004; 181:378-83; PMID:15052376; http://dx.doi.org/10.1007/s00203-004-0667-3
  • Schobel F, Jacobsen ID, Brock M. Evaluation of lysine biosynthesis as an antifungal drug target: biochemical characterization of Aspergillus fumigatus homocitrate synthase and virulence studies. Eukaryot Cell 2010; 9:878-93; PMID:20363898; http://dx.doi.org/10.1128/EC.00020-10
  • Amich J, Dumig M, O'Keeffe G, Binder J, Doyle S, Beilhack A, et al. Exploring sulfur assimilation of Aspergillus fumigatus reveals biosynthesis of sulfur-containing amino acids as a virulence determinant. Infect Immun 2016; 84(4):917-29; PMID:26787716
  • Dietl AM, Amich J, Leal S, Beckmann N, Binder U, Beilhack A, et al. Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus. Virulence 2016; 7(4):465-476; http://dx.doi.org/10.1080/21505594.2016.1146848
  • Busch S, Hoffmann B, Valerius O, Starke K, Duvel K, Braus GH. Regulation of the Aspergillus nidulans hisB gene by histidine starvation. Curr Genet 2001; 38:314-22; PMID:11270573; http://dx.doi.org/10.1007/s002940000171
  • Alcazar-Fuoli L, Buitrago M, Gomez-Lopez A, Mellado E. An alternative host model of a mixed fungal infection by azole susceptible and resistant Aspergillus spp strains. Virulence 2015; 6:376-84; PMID:26065322; http://dx.doi.org/10.1080/21505594.2015.1025192
  • Mylonakis E. Galleria mellonella and the study of fungal pathogenesis: making the case for another genetically tractable model host. Mycopathologia 2008; 165:1-3; PMID:18060516; http://dx.doi.org/10.1007/s11046-007-9082-z
  • Haas H. Fungal siderophore metabolism with a focus on Aspergillus fumigatus. Nat Prod Rep 2014; 31:1266-76; PMID:25140791; http://dx.doi.org/10.1039/C4NP00071D

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