Antibodies to Staphylococcus aureus capsular polysaccharides 5 and 8 perform similarly in vitro but are functionally distinct in vivo

References

• Scully IL, Liberator PA, Jansen KU, Anderson AS. Covering all the bases: Preclinical development of an effective Staphylococcus aureus vaccine. Front Immunol 2014; 5:109; PMID:24715889; http://dx.doi.org/10.3389/fimmu.2014.00109
   PubMed Web of Science ®Google Scholar
• Joshi A, Pancari G, Cope L, Bowman EP, Cua D, Proctor RA, McNeely T. Immunization with Staphylococcus aureus iron regulated surface determinant B (IsdB) confers protection via Th17/IL17 pathway in a murine sepsis model. Hum Vaccin Immunother 2012; 8:336-46; PMID:22327491; http://dx.doi.org/10.4161/hv.18946
   PubMed Web of Science ®Google Scholar
• Montgomery CP, Daniels M, Zhao F, Alegre ML, Chong AS, Daum RS. Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A. Infect Immun 2014; 82:2125-34; PMID:24614654; http://dx.doi.org/10.1128/IAI.01491-14
   PubMed Web of Science ®Google Scholar
• Yeaman MR, Filler SG, Chaili S, Barr K, Wang H, Kupferwasser D, Hennessey JP, Fu Y, Schmidt CS, Edwards JE, et al. Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection. Proc Natl Acad Sci U S A 2014; 111:E5555-63; PMID:25489065; http://dx.doi.org/10.1073/pnas.1415610111
   PubMed Web of Science ®Google Scholar
• Homaira N, Rawlinson W, Snelling TL, Jaffe A. Effectiveness of palivizumab in preventing RSV hospitalization in high risk children: a real-world perspective. Int J Pediatr 2014; 2014:571609; PMID:25548575; http://dx.doi.org/10.1155/2014/571609
   PubMedGoogle Scholar
• Gentile G, Foà R. Viral infections associated with the clinical use of monoclonal antibodies. Clin Microbiol Infect 2011; 17:1769-75; PMID:22023708; http://dx.doi.org/10.1111/j.1469-0691.2011.03680.x
   PubMed Web of Science ®Google Scholar
• Focosi D, Maggi F, Pistello M, Boggi U, Scatena F. Immunosuppressive monoclonal antibodies: current and next generation. Clin Microbiol Infect 2011; 17:1759-68; PMID:21995285; http://dx.doi.org/10.1111/j.1469-0691.2011.03677.x
   PubMed Web of Science ®Google Scholar
• Murad JP, Lin OA, Espinosa EV, Khasawneh FT. Current and experimental antibody-based therapeutics: insights, breakthroughs, setbacks and future directions. Curr Mol Med 2013; 13:165-78; PMID:22834842; http://dx.doi.org/10.2174/156652413804486322
   PubMed Web of Science ®Google Scholar
• Yang Z, Ramsey J, Hamza T, Zhang Y, Li S, Yfantis HG, Lee D, Hernandez LD, Seghezzi W, Furneisen JM, et al. Mechanisms of protection against Clostridium difficile infection by the monoclonal antitoxin antibodies actoxumab and bezlotoxumab. Infect Immun 2015; 83:822-31; PMID:25486992; http://dx.doi.org/10.1128/IAI.02897-14
   PubMed Web of Science ®Google Scholar
• Otto M. Novel targeted immunotherapy approaches for staphylococcal infection. Expert Opin Biol Ther 2010; 10:1049-59; PMID:20528609; http://dx.doi.org/10.1517/14712598.2010.495115
   PubMed Web of Science ®Google Scholar
• Schaffer AC, Lee JC. Staphylococcal vaccines and immunotherapies. Infect Dis Clin North Am 2009; 23:153-71; PMID:19135920; http://dx.doi.org/10.1016/j.idc.2008.10.005
   PubMed Web of Science ®Google Scholar
• Fowler VG, Jr., Proctor RA. Where does a Staphylococcus aureus vaccine stand? Clin Microbiol Infect 2014; 20(Suppl 5):66-75; PMID:24476315
   PubMed Web of Science ®Google Scholar
• Weems JJ, Steinberg JP, Filler S, Baddley JW, Corey GR, Sampathkumar P, Winston L, John JF, Kubin CJ, Talwani R. Phase II, randomized, double-blind, multicenter study comparing the safety and pharmacokinetics of tefibazumab to placebo for treatment of Staphylococcus aureus bacteremia. Antimicrob Agents Chemother 2006; 50:2751-5; PMID:16870768; http://dx.doi.org/10.1128/AAC.00096-06
   PubMed Web of Science ®Google Scholar
• Verdier I, Durand G, Bes M, Taylor KL, Lina G, Vandenesch F, Fattom AI, Etienne J, Verdier I, Durand G, et al. Identification of the capsular polysaccharides in Staphylococcus aureus clinical isolates by PCR and agglutination tests. J Clin Microbiol 2007; 45:725-9; PMID:17202275; http://dx.doi.org/10.1128/JCM.01572-06
   PubMed Web of Science ®Google Scholar
• Roghmann M, Taylor KL, Gupte A, Zhan M, Johnson JA, Cross A, Edelman R, Fattom AI. Epidemiology of capsular and surface polysaccharide in Staphylococcus aureus infections complicated by bacteraemia. J Hosp Infect 2005; 59:27-32; PMID:15571850; http://dx.doi.org/10.1016/j.jhin.2004.07.014
   PubMed Web of Science ®Google Scholar
• Trotter CL, McVernon J, Ramsay ME, Whitney CG, Mulholland EK, Goldblatt D, Hombach J, Kieny MP, subgroup S. Optimising the use of conjugate vaccines to prevent disease caused by Haemophilus influenzae type b, Neisseria meningitidis and Streptococcus pneumoniae. Vaccine 2008; 26:4434-45; PMID:18617296; http://dx.doi.org/10.1016/j.vaccine.2008.05.073
   PubMed Web of Science ®Google Scholar
• Watts A, Ke D, Wang Q, Pillay A, Nicholson-Weller A, Lee JC. Staphylococcus aureus strains that express serotype 5 or serotype 8 capsular polysaccharides differ in virulence. Infect Immun 2005; 73:3502-11; PMID:15908379; http://dx.doi.org/10.1128/IAI.73.6.3502-3511.2005
   PubMed Web of Science ®Google Scholar
• Benjamin DK, Schelonka R, White R, Holley HP, Bifano E, Cummings J, Adcock K, Kaufman D, Puppala B, Riedel P, et al. A blinded, randomized, multicenter study of an intravenous Staphylococcus aureus immune globulin. J Perinatol 2006; 26:290-5; PMID:16598296; http://dx.doi.org/10.1038/sj.jp.7211496
   PubMed Web of Science ®Google Scholar
• Rupp ME, Holley HP, Jr, Lutz J, Dicpinigaitis PV, Woods CW, Levine DP, Veney N, Fowler VG, Jr, Rupp ME, Holley HP, Jr, et al. Phase II, randomized, multicenter, double-blind, placebo-controlled trial of a polyclonal anti-Staphylococcus aureus capsular polysaccharide immune globulin in treatment of Staphylococcus aureus bacteremia. Antimicrob Agents Chemother 2007; 51:4249-54; PMID:17893153; http://dx.doi.org/10.1128/AAC.00570-07
   PubMed Web of Science ®Google Scholar
• Hilliard JJ, Datta V, Tkaczyk C, Hamilton M, Sadowska A, Jones-Nelson O, O'Day T, Weiss WJ, Szarka S, Nguyen V, et al. Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model. Antimicrob Agents Chemother 2015; 59:299-309; PMID:25348518; http://dx.doi.org/10.1128/AAC.03918-14
   PubMed Web of Science ®Google Scholar
• Hua L, Hilliard JJ, Shi Y, Tkaczyk C, Cheng LI, Yu X, Datta V, Ren S, Feng H, Zinsou R, et al. Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia. Antimicrob Agents Chemother 2014; 58:1108-17; PMID:24295977; http://dx.doi.org/10.1128/AAC.02190-13
   PubMed Web of Science ®Google Scholar
• Tkaczyk C, Hua L, Varkey R, Shi Y, Dettinger L, Woods R, Barnes A, MacGill RS, Wilson S, Chowdhury P, et al. Identification of anti-alpha toxin monoclonal antibodies that reduce the severity of Staphylococcus aureus dermonecrosis and exhibit a correlation between affinity and potency. Clin Vaccine Immunol 2012; 19:377-85; PMID:22237895; http://dx.doi.org/10.1128/CVI.05589-11
   PubMed Web of Science ®Google Scholar
• Rouha H, Badarau A, Visram ZC, Battles MB, Prinz B, Magyarics Z, Nagy G, Mirkina I, Stulik L, Zerbs M, et al. Five birds, one stone: neutralization of alpha-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody. MAbs 2015; 7:243-54; PMID:25523282; http://dx.doi.org/10.4161/19420862.2014.985132
   PubMed Web of Science ®Google Scholar
• Thakker M, Park J-S, Carey V, Lee JC. Staphylococcus aureus serotype 5 capsular polysaccharide is antiphagocytic and enhances bacterial virulence in a murine bacteremia model. Infect Immun 1998; 66:5183-9; PMID:9784520
   PubMed Web of Science ®Google Scholar
• Wacker M, Wang L, Kowarik M, Dowd M, Lipowsky G, Faridmoayer A, Shields K, Park S, Alaimo C, Kelley KA, et al. Prevention of Staphylococcus aureus infections by glycoprotein vaccines synthesized in Escherichia coli. J Infect Dis 2014; 209:1551-61; PMID:24308931; http://dx.doi.org/10.1093/infdis/jit800
   PubMed Web of Science ®Google Scholar
• Park S, Gerber S, Lee JC. Antibodies to Staphylococcus aureus serotype 8 capsular polysaccharide react with and protect against serotype 5 and 8 isolates. Infect Immun 2014; 82:5049-55; PMID:25245803; http://dx.doi.org/10.1128/IAI.02373-14
   PubMed Web of Science ®Google Scholar
• Szu SC, Li XR, Stone AL, Robbins JB. Relation between structure and immunologic properties of the Vi capsular polysaccharide. Infect Immun 1991; 59:4555-61; PMID:1937814
   PubMed Web of Science ®Google Scholar
• Fusco PC, Farley EK, Huang CH, Moore S, Michon F. Protective meningococcal capsular polysaccharide epitopes and the role of O acetylation. Clin Vaccine Immunol 2007; 14:577-84; PMID:17376859; http://dx.doi.org/10.1128/CVI.00009-07
   PubMed Web of Science ®Google Scholar
• Berry DS, Lynn F, Lee CH, Frasch CE, Bash MC. Effect of O acetylation of Neisseria meningitidis serogroup A capsular polysaccharide on development of functional immune responses. Infect Immun 2002; 70:3707-13; PMID:12065513; http://dx.doi.org/10.1128/IAI.70.7.3707-3713.2002
   PubMed Web of Science ®Google Scholar
• Fattom AI, Sarwar J, Basham L, Ennifar S, Naso R. Antigenic determinants of Staphylococcus aureus type 5 and type 8 capsular polysaccharide vaccines. Infect Immun 1998; 66:4588-92; PMID:9746554
   PubMed Web of Science ®Google Scholar
• Holden MT, Feil EJ, Lindsay JA, Peacock SJ, Day NP, Enright MC, Foster TJ, Moore CE, Hurst L, Atkin R, et al. Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci U S A 2004; 101:9786-91; PMID:15213324; http://dx.doi.org/10.1073/pnas.0402521101
   PubMed Web of Science ®Google Scholar
• Montgomery CP, Boyle-Vavra S, Adem PV, Lee JC, Husain AN, Clasen J, Daum RS. Comparison of virulence in community-associated methicillin-resistant Staphylococcus aureus pulsotypes USA300 and USA400 in a rat model of pneumonia. J Infect Dis 2008; 198:561-70; PMID:18598194; http://dx.doi.org/10.1086/590157
   PubMed Web of Science ®Google Scholar
• Cook J, Hepler R, Pancari G, Kuklin N, Fan H, Wang XM, Cope L, Tan C, Joyce J, Onishi J, et al. Staphylococcus aureus capsule type 8 antibodies provide inconsistent efficacy in murine models of staphylococcal infection. Hum Vaccin 2009; 5:254-63; PMID:18787395; http://dx.doi.org/10.4161/hv.5.4.6765
   PubMed Web of Science ®Google Scholar
• Boyle-Vavra S, Li X, Alam MT, Read TD, Sieth J, Cywes-Bentley C, Dobbins G, David MZ, Kumar N, Eells SJ, et al. USA300 and USA500 clonal lineages of Staphylococcus aureus do not produce a capsular polysaccharide due to conserved mutations in the cap5 locus. MBio 2015; 6:e02585-14; PMID:25852165; http://dx.doi.org/10.1128/mBio.02585-14
   PubMed Web of Science ®Google Scholar
• Arbeit RD, Dunn RM. Expression of capsular polysaccharide during experimental focal infection with Staphylococcus aureus. J Infect Dis 1987; 156:947-52; PMID:3680994; http://dx.doi.org/10.1093/infdis/156.6.947
   PubMed Web of Science ®Google Scholar
• Arbeit RD, Nelles MJ. Capsular polysaccharide antigenemia in rats with experimental endocarditis due to Staphylococcus aureus. J Infect Dis 1987; 155:242-6; PMID:3805763; http://dx.doi.org/10.1093/infdis/155.2.242
   PubMed Web of Science ®Google Scholar
• Hochkeppel HK, Braun DG, Vischer W, Imm A, Sutter S, Staeubli U, Guggenheim R, Kaplan EL, Boutonnier A, Fournier JM. Serotyping and electron microscopy studies of Staphylococcus aureus clinical isolates with monoclonal antibodies to capsular polysaccharide types 5 and 8. J Clin Microbiol 1987; 25:526-30; PMID:2437148
   PubMed Web of Science ®Google Scholar
• Nanra JS, Buitrago SM, Crawford S, Ng J, Fink PS, Hawkins J, Scully IL, McNeil LK, Aste-Amezaga JM, Cooper D, et al. Capsular polysaccharides are an important immune evasion mechanism for Staphylococcus aureus. Hum Vaccin Immunother 2013; 9:480-7; PMID:23249887; http://dx.doi.org/10.4161/hv.23223
   PubMed Web of Science ®Google Scholar
• Skurnik D, Merighi M, Grout M, Gadjeva M, Maira-Litran T, Ericsson M, Goldmann DA, Huang SS, Datta R, Lee JC, et al. Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice. J Clin Invest 2010; 120:3220-33; PMID:20739753; http://dx.doi.org/10.1172/JCI42748
   PubMed Web of Science ®Google Scholar
• Tuchscherr LP, Buzzola FR, Alvarez LP, Lee JC, Sordelli DO. Antibodies to capsular polysaccharide and clumping factor A prevent mastitis and the emergence of unencapsulated and small-colony variants of Staphylococcus aureus in mice. Infect Immun 2008; 76:5738-44; PMID:18809660; http://dx.doi.org/10.1128/IAI.00874-08
   PubMed Web of Science ®Google Scholar
• Lee JC, Park JS, Shepherd SE, Carey V, Fattom A. Protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide in a modified model of endocarditis in rats. Infect Immun 1997; 65:4146-51; PMID:9317020
   PubMed Web of Science ®Google Scholar
• Shinefield H, Black S, Fattom A, Horwith G, Rasgon S, Ordonez J, Yeoh H, Law D, Robbins JB, Schneerson R, et al. Use of a Staphylococcus aureus conjugate vaccine in patients receiving hemodialysis. N Engl J Med 2002; 346:491-6; PMID:11844850; http://dx.doi.org/10.1056/NEJMoa011297
   PubMed Web of Science ®Google Scholar
• Fattom A, Matalon A, Buerkert J, Taylor K, Damaso S, Boutriau D. Efficacy profile of a bivalent Staphylococcus aureus glycoconjugated vaccine in adults on hemodialysis: Phase III randomized study. Hum Vaccin Immunother 2015; 11:632-41; PMID:25483694; http://dx.doi.org/10.4161/hv.34414
   PubMed Web of Science ®Google Scholar
• Levy J, Licini L, Haelterman E, Moris P, Lestrate P, Damaso S, Van Belle P, Boutriau D. Safety and immunogenicity of an investigational 4-component Staphylococcus aureus vaccine with or without AS03B adjuvant: Results of a randomized phase I trial. Hum Vaccin Immunother 2015; 11:620-31; PMID:25715157; http://dx.doi.org/10.1080/21645515.2015.1011021
   PubMed Web of Science ®Google Scholar
• Diekema DJ, Richter SS, Heilmann KP, Dohrn CL, Riahi F, Tendolkar S, McDanel JS, Doern GV. Continued emergence of USA300 methicillin-resistant Staphylococcus aureus in the United States: results from a nationwide surveillance study. Infect Control Hosp Epidemiol 2014; 35:285-92; PMID:24521595; http://dx.doi.org/10.1086/675283
   PubMed Web of Science ®Google Scholar
• van der Mee-Marquet N, Poisson DM, Lavigne JP, Francia T, Tristan A, Vandenesch F, Quentin R, Bertrand X. The incidence of Staphylococcus aureus ST8-USA300 among French pediatric inpatients is rising. Eur J Clin Microbiol Infect Dis 2015; 34:935-42; PMID:25575950; http://dx.doi.org/10.1007/s10096-014-2308-3
   PubMed Web of Science ®Google Scholar
• Uhlemann AC, Otto M, Lowy FD, DeLeo FR. Evolution of community- and healthcare-associated methicillin-resistant Staphylococcus aureus. Infect Genet Evol 2014; 21:563-74; PMID:23648426; http://dx.doi.org/10.1016/j.meegid.2013.04.030
   PubMed Web of Science ®Google Scholar
• Nimmo GR. USA300 abroad: global spread of a virulent strain of community-associated methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect 2012; 18:725-34; PMID:22448902; http://dx.doi.org/10.1111/j.1469-0691.2012.03822.x
   PubMed Web of Science ®Google Scholar
• Kim HK, Emolo C, DeDent AC, Falugi F, Missiakas DM, Schneewind O. Protein A-specific monoclonal antibodies and prevention of Staphylococcus aureus disease in mice. Infect Immun 2012; 80:3460-70; PMID:22825452; http://dx.doi.org/10.1128/IAI.00230-12
   PubMed Web of Science ®Google Scholar
• Hall AE, Domanski PJ, Patel PR, Vernachio JH, Syribeys PJ, Gorovits EL, Johnson MA, Ross JM, Hutchins JT, Patti JM, et al. Characterization of a protective monoclonal antibody recognizing Staphylococcus aureus MSCRAMM protein clumping factor A. Infect Immun 2003; 71:6864-70; PMID:14638774; http://dx.doi.org/10.1128/IAI.71.12.6864-6870.2003
   PubMed Web of Science ®Google Scholar
• Bhasin N, Albus A, Michon F, Livolsi PJ, Park J-S, Lee JC. Identification of a gene essential for O-acetylation of the Staphylococcus aureus type 5 capsular polysaccharide. Mol Microbiol 1998; 27:9-21; PMID:9466251; http://dx.doi.org/10.1046/j.1365-2958.1998.00646.x
   PubMed Web of Science ®Google Scholar
• Jones C. Revised structures for the capsular polysaccharides from Staphylococcus aureus types 5 and 8, components of novel glycoconjugate vaccines. Carbohydr Res 2005; 340:1097-106; PMID:15797125; http://dx.doi.org/10.1016/j.carres.2005.02.001
   PubMed Web of Science ®Google Scholar
• Kozel TR, MacGill RS, Percival A, Zhou Q. Biological activities of naturally occurring antibodies reactive with Candida albicans mannan. Infect Immun 2004; 72:209-18; PMID:14688098; http://dx.doi.org/10.1128/IAI.72.1.209-218.2004
   PubMed Web of Science ®Google Scholar
• Moss RB. The role of IgG subclass antibodies in chronic infection: the case of cystic fibrosis. N Engl Reg Allergy Proc 1988; 9:57-61; PMID:3362109; http://dx.doi.org/10.2500/108854188778984491
   PubMedGoogle Scholar
• Han Y, Kozel TR, Zhang MX, MacGill RS, Carroll MC, Cutler JE. Complement is essential for protection by an IgM and an IgG3 monoclonal antibody against experimental, hematogenously disseminated candidiasis. J Immunol 2001; 167:1550-7; PMID:11466376; http://dx.doi.org/10.4049/jimmunol.167.3.1550
   PubMed Web of Science ®Google Scholar
• Zhang MX, Kozel TR. Mannan-specific immunoglobulin G antibodies in normal human serum accelerate binding of C3 to Candida albicans via the alternative complement pathway. Infect Immun 1998; 66:4845-50; PMID:9746588
   PubMed Web of Science ®Google Scholar
• Choi EH, Zhang F, Lu YJ, Malley R. Capsular polysacharide (CPS) release by serotype 3 pneumococcal strains reduces the protective effect of anti-type 3 CPS antibodies. Clin Vaccine Immunol 2016; 23:162-7; http://dx.doi.org/10.1128/CVI.00591-15
   PubMed Web of Science ®Google Scholar
• Tzianabos AO, Wang JY, Lee JC. Structural rationale for the modulation of abscess formation by Staphylococcus aureus capsular polysaccharides. Proc Natl Acad Sci U S A 2001; 98:9365-70; PMID:11470905; http://dx.doi.org/10.1073/pnas.161175598
   PubMed Web of Science ®Google Scholar
• Gray BM. ELISA methodology for polysaccharide antigens: protein coupling of polysaccharides for adsorption to plastic tubes. J Immunol 1979; 28:187-92.
   Google Scholar
• Guttormsen HK, Wetzler LM, Finberg RW, Kasper DL. Immunologic memory induced by a glycoconjugate vaccine in a murine adoptive lymphocyte transfer model. Infect Immun 1998; 66:2026-32; PMID:9573085
   PubMed Web of Science ®Google Scholar
• Lee JC, Liu MJ, Parsonnet J, Arbeit RD. Expression of type-8 capsular polysaccharide and production of toxic shock syndrome toxin-1 are associated among vaginal isolates of Staphylococcus aureus. J Clin Microbiol 1990; 28:2612-5; PMID:2279990
   PubMed Web of Science ®Google Scholar
• Li W, Ulm H, Rausch M, Li X, O'Riordan K, Lee JC, Schneider T, Muller CE. Analysis of the Staphylococcus aureus capsule biosynthesis pathway in vitro: characterization of the UDP-GlcNAc C6 dehydratases CapD and CapE and identification of enzyme inhibitors. Int J Med Microbiol 2014; 304:958-69; PMID:25023075; http://dx.doi.org/10.1016/j.ijmm.2014.06.002
   PubMed Web of Science ®Google Scholar
• Lee JC, Takeda S, Livolsi PJ, Paoletti LC. Effects of in vitro and in vivo growth conditions on expression of type-8 capsular polysaccharide by Staphylococcus aureus. Infect Immun 1993; 61:1853-8; PMID:8478074
   PubMed Web of Science ®Google Scholar
• Schaffer AC, Solinga RM, Cocchiaro J, Portoles M, Kiser KB, Risley A, Randall SM, Valtulina V, Speziale P, Walsh E, et al. Immunization with Staphylococcus aureus clumping factor B, a major determinant in nasal carriage, reduces nasal colonization in a murine model. Infect Immun 2006; 74:2145-53; PMID:16552044; http://dx.doi.org/10.1128/IAI.74.4.2145-2153.2006
   PubMed Web of Science ®Google Scholar
• Gill SR, Fouts DE, Archer GL, Mongodin EF, Deboy RT, Ravel J, Paulsen IT, Kolonay JF, Brinkac L, Beanan M, et al. Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain. J Bacteriol 2005; 187:2426-38; PMID:15774886; http://dx.doi.org/10.1128/JB.187.7.2426-2438.2005
   PubMed Web of Science ®Google Scholar
• Takeuchi F, Watanabe S, Baba T, Yuzawa H, Ito T, Morimoto Y, Kuroda M, Cui L, Takahashi M, Ankai A, et al. Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species. J Bacteriol 2005; 187:7292-308; PMID:16237012; http://dx.doi.org/10.1128/JB.187.21.7292-7308.2005
   PubMed Web of Science ®Google Scholar
• Kuroda M, Yamashita A, Hirakawa H, Kumano M, Morikawa K, Higashide M, Maruyama A, Inose Y, Matoba K, Toh H, et al. Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection. Proc Natl Acad Sci U S A 2005; 102:13272-7; PMID:16135568; http://dx.doi.org/10.1073/pnas.0502950102
   PubMed Web of Science ®Google Scholar
• Duthie ES, Lorenz LL. Staphylococcal coagulase; mode of action and antigenicity. J Gen Microbiol 1952; 6:95-107; PMID:14927856
   PubMedGoogle Scholar
• Kuroda M, Ohta T, Uchiyama I, Baba T, Yuzawa H, Kobayashi I, Cui L, Oguchi A, Aoki K, Nagai Y, et al. Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet 2001; 357:1225-40; PMID:11418146; http://dx.doi.org/10.1016/S0140-6736(00)04403-2
   PubMed Web of Science ®Google Scholar
• Baker CJ. Fatal septicemia due to Staphylococcus aureus 502A. Report of a case and review of the infectious complications of bacterial interference programs. Am J Dis Child 1972; 123:45-8; PMID:5010551; http://dx.doi.org/10.1001/archpedi.1972.02110070095012
   PubMedGoogle Scholar
• Fattom A, Schneerson R, Szu SC, Vann WF, Shiloach J, Karakawa WW, Robbins JB. Synthesis and immunologic properties in mice of vaccines composed of Staphylococcus aureus type 5 and type 8 capsular polysaccharides conjugated to Pseudomonas aeruginosa exotoxin A. Infect Immun 1990; 58:2367-74; PMID:2114365
   PubMed Web of Science ®Google Scholar
• Schlievert PM, Kelly JA. Staphylococcal pyrogenic exotoxin type C: further characterization. Ann Intern Med 1982; 96:982-6; PMID:7091979; http://dx.doi.org/10.7326/0003-4819-96-6-982
   PubMed Web of Science ®Google Scholar
• Stegger M, Wirth T, Andersen PS, Skov RL, De Grassi A, Simoes PM, Tristan A, Petersen A, Aziz M, Kiil K, et al. Origin and evolution of European community-acquired methicillin-resistant Staphylococcus aureus. MBio 2014; 5:e01044-14; PMID:25161186; http://dx.doi.org/10.1128/mBio.01044-14
   PubMed Web of Science ®Google Scholar
• Karakawa WW, Vann WF. Capsular polysaccharides of Staphylococcus aureus. Semin Infect Dis 1982; 4:285-93.
   Google Scholar
• Drapeau GR, Boily Y, Houmard J. Purification and properties of an extracellular protease of Staphylococcus aureus. J Biol Chem 1972; 247:6720-6; PMID:4627743
   PubMed Web of Science ®Google Scholar
• Li M, Diep BA, Villaruz AE, Braughton KR, Jiang X, DeLeo FR, Chambers HF, Lu Y, Otto M. Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci U S A 2009; 106:5883-8; PMID:19293374; http://dx.doi.org/10.1073/pnas.0900743106
   PubMed Web of Science ®Google Scholar
• Cassat JE, Dunman PM, McAleese F, Murphy E, Projan SJ, Smeltzer MS. Comparative genomics of Staphylococcus aureus musculoskeletal isolates. J Bacteriol 2005; 187:576-92; PMID:15629929; http://dx.doi.org/10.1128/JB.187.2.576-592.2005
   PubMed Web of Science ®Google Scholar
• Herron LL, Chakravarty R, Dwan C, Fitzgerald JR, Musser JM, Retzel E, Kapur V. Genome sequence survey identifies unique sequences and key virulence genes with unusual rates of amino acid substitution in bovine Staphylococcus aureus. Infect Immun 2002; 70:3978-81; PMID:12065548; http://dx.doi.org/10.1128/IAI.70.7.3978-3981.2002
   PubMed Web of Science ®Google Scholar
• Baba T, Takeuchi F, Kuroda M, Yuzawa H, Aoki K, Oguchi A, Nagai Y, Iwama N, Asano K, Naimi T, et al. Genome and virulence determinants of high virulence community-acquired MRSA. Lancet 2002; 359:1819-27; PMID:12044378; http://dx.doi.org/10.1016/S0140-6736(02)08713-5
   PubMed Web of Science ®Google Scholar
• Novick R. Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus. Virology 1967; 33:155-66; PMID:4227577; http://dx.doi.org/10.1016/0042-6822(67)90105-5
   PubMed Web of Science ®Google Scholar
• Voyich JM, Otto M, Mathema B, Braughton KR, Whitney AR, Welty D, Long RD, Dorward DW, Gardner DJ, Lina G, et al. Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J Infect Dis 2006; 194:1761-70; PMID:17109350; http://dx.doi.org/10.1086/509506
   PubMed Web of Science ®Google Scholar
• Levinson AI, Tar L, Carafa C, Haidar M. Staphylococcus aureus Cowan I. Potent stimulus of immunoglobulin M rheumatoid factor production. J Clin Invest 1986; 78:612-7; PMID:3489006; http://dx.doi.org/10.1172/JCI112617
   PubMed Web of Science ®Google Scholar